-- dump date 20140620_004254 -- class Genbank::misc_feature -- table misc_feature_note -- id note 381754000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 381754000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 381754000004 Walker A motif; other site 381754000005 ATP binding site [chemical binding]; other site 381754000006 Walker B motif; other site 381754000007 arginine finger; other site 381754000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 381754000009 DnaA box-binding interface [nucleotide binding]; other site 381754000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 381754000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 381754000012 putative DNA binding surface [nucleotide binding]; other site 381754000013 dimer interface [polypeptide binding]; other site 381754000014 beta-clamp/clamp loader binding surface; other site 381754000015 beta-clamp/translesion DNA polymerase binding surface; other site 381754000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 381754000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754000018 Walker A/P-loop; other site 381754000019 ATP binding site [chemical binding]; other site 381754000020 Q-loop/lid; other site 381754000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754000022 ABC transporter signature motif; other site 381754000023 Walker B; other site 381754000024 D-loop; other site 381754000025 H-loop/switch region; other site 381754000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 381754000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754000028 Mg2+ binding site [ion binding]; other site 381754000029 G-X-G motif; other site 381754000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 381754000031 anchoring element; other site 381754000032 dimer interface [polypeptide binding]; other site 381754000033 ATP binding site [chemical binding]; other site 381754000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 381754000035 active site 381754000036 putative metal-binding site [ion binding]; other site 381754000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 381754000038 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 381754000039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 381754000040 putative acyl-acceptor binding pocket; other site 381754000041 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 381754000042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754000043 active site 381754000044 motif I; other site 381754000045 motif II; other site 381754000046 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 381754000047 HD domain; Region: HD; pfam01966 381754000048 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 381754000049 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 381754000050 dimer interface [polypeptide binding]; other site 381754000051 motif 1; other site 381754000052 active site 381754000053 motif 2; other site 381754000054 motif 3; other site 381754000055 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 381754000056 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 381754000057 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 381754000058 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 381754000059 putative acyl-acceptor binding pocket; other site 381754000060 PilZ domain; Region: PilZ; pfam07238 381754000061 hypothetical protein; Provisional; Region: PRK11212 381754000062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754000063 TPR motif; other site 381754000064 TPR repeat; Region: TPR_11; pfam13414 381754000065 binding surface 381754000066 Cation transport protein; Region: TrkH; cl17365 381754000067 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 381754000068 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 381754000069 TrkA-N domain; Region: TrkA_N; pfam02254 381754000070 TrkA-C domain; Region: TrkA_C; pfam02080 381754000071 TrkA-N domain; Region: TrkA_N; pfam02254 381754000072 TrkA-C domain; Region: TrkA_C; pfam02080 381754000073 16S rRNA methyltransferase B; Provisional; Region: PRK10901 381754000074 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 381754000075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754000076 S-adenosylmethionine binding site [chemical binding]; other site 381754000077 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 381754000078 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 381754000079 putative active site [active] 381754000080 substrate binding site [chemical binding]; other site 381754000081 putative cosubstrate binding site; other site 381754000082 catalytic site [active] 381754000083 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 381754000084 substrate binding site [chemical binding]; other site 381754000085 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 381754000086 active site 381754000087 catalytic residues [active] 381754000088 metal binding site [ion binding]; metal-binding site 381754000089 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 381754000090 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754000091 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 381754000092 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 381754000093 DNA protecting protein DprA; Region: dprA; TIGR00732 381754000094 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 381754000095 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 381754000096 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 381754000097 NADP binding site [chemical binding]; other site 381754000098 dimer interface [polypeptide binding]; other site 381754000099 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 381754000100 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 381754000101 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 381754000102 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 381754000103 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 381754000104 shikimate binding site; other site 381754000105 NAD(P) binding site [chemical binding]; other site 381754000106 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 381754000107 Zn binding site [ion binding]; other site 381754000108 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 381754000109 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 381754000110 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 381754000111 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 381754000112 Sulfate transporter family; Region: Sulfate_transp; pfam00916 381754000113 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 381754000114 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 381754000115 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 381754000116 choline-sulfatase; Region: chol_sulfatase; TIGR03417 381754000117 Sulfatase; Region: Sulfatase; cl17466 381754000118 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 381754000119 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 381754000120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000121 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 381754000122 dimerization interface [polypeptide binding]; other site 381754000123 substrate binding pocket [chemical binding]; other site 381754000124 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 381754000125 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754000126 putative binding surface; other site 381754000127 active site 381754000128 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754000129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754000130 active site 381754000131 phosphorylation site [posttranslational modification] 381754000132 intermolecular recognition site; other site 381754000133 dimerization interface [polypeptide binding]; other site 381754000134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754000135 DNA binding residues [nucleotide binding] 381754000136 dimerization interface [polypeptide binding]; other site 381754000137 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 381754000138 PcrB family; Region: PcrB; pfam01884 381754000139 substrate binding site [chemical binding]; other site 381754000140 active site 381754000141 catalytic residues [active] 381754000142 heterodimer interface [polypeptide binding]; other site 381754000143 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 381754000144 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 381754000145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754000146 catalytic residue [active] 381754000147 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754000148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754000150 dimerization interface [polypeptide binding]; other site 381754000151 Dodecin; Region: Dodecin; pfam07311 381754000152 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 381754000153 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 381754000154 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 381754000155 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 381754000156 haemagglutination activity domain; Region: Haemagg_act; pfam05860 381754000157 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 381754000158 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 381754000159 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 381754000160 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 381754000161 Predicted membrane protein [Function unknown]; Region: COG3174 381754000162 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 381754000163 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 381754000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 381754000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 381754000166 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754000167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754000168 non-specific DNA binding site [nucleotide binding]; other site 381754000169 salt bridge; other site 381754000170 sequence-specific DNA binding site [nucleotide binding]; other site 381754000171 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 381754000172 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 381754000173 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 381754000174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812 381754000175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754000176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000177 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754000178 putative effector binding pocket; other site 381754000179 dimerization interface [polypeptide binding]; other site 381754000180 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 381754000181 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 381754000182 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 381754000183 catalytic residues [active] 381754000184 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 381754000185 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 381754000186 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 381754000187 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 381754000188 Eukaryotic phosphomannomutase; Region: PMM; cl17107 381754000189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754000190 motif II; other site 381754000191 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 381754000192 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 381754000193 trimer interface [polypeptide binding]; other site 381754000194 putative metal binding site [ion binding]; other site 381754000195 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 381754000196 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 381754000197 active site 381754000198 Zn binding site [ion binding]; other site 381754000199 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 381754000200 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 381754000201 Immunoglobulin domain; Region: Ig; cl11960 381754000202 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 381754000203 active site 381754000204 catalytic residues [active] 381754000205 DNA binding site [nucleotide binding] 381754000206 Int/Topo IB signature motif; other site 381754000207 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 381754000208 active site 381754000209 catalytic residues [active] 381754000210 DNA binding site [nucleotide binding] 381754000211 Int/Topo IB signature motif; other site 381754000212 HsdM N-terminal domain; Region: HsdM_N; pfam12161 381754000213 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 381754000214 Methyltransferase domain; Region: Methyltransf_26; pfam13659 381754000215 S-adenosylmethionine binding site [chemical binding]; other site 381754000216 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 381754000217 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 381754000218 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 381754000219 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 381754000220 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 381754000221 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 381754000222 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 381754000223 ATP binding site [chemical binding]; other site 381754000224 putative Mg++ binding site [ion binding]; other site 381754000225 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754000226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754000227 non-specific DNA binding site [nucleotide binding]; other site 381754000228 salt bridge; other site 381754000229 sequence-specific DNA binding site [nucleotide binding]; other site 381754000230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 381754000231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 381754000232 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 381754000233 DNA binding site [nucleotide binding] 381754000234 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 381754000235 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 381754000236 active site 381754000237 catalytic residues [active] 381754000238 DNA binding site [nucleotide binding] 381754000239 Int/Topo IB signature motif; other site 381754000240 Y-family of DNA polymerases; Region: PolY; cl12025 381754000241 putative mercuric reductase; Provisional; Region: PRK13748 381754000242 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754000243 metal-binding site [ion binding] 381754000244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754000245 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754000246 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 381754000247 putative mercury transport protein MerC; Provisional; Region: PRK13755 381754000248 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754000249 metal-binding site [ion binding] 381754000250 putative mercuric transport protein; Provisional; Region: PRK13751 381754000251 putative transcriptional regulator MerR; Provisional; Region: PRK13752 381754000252 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 381754000253 DNA binding residues [nucleotide binding] 381754000254 dimer interface [polypeptide binding]; other site 381754000255 mercury binding site [ion binding]; other site 381754000256 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 381754000257 active site 381754000258 catalytic residues [active] 381754000259 DNA binding site [nucleotide binding] 381754000260 Int/Topo IB signature motif; other site 381754000261 Y-family of DNA polymerases; Region: PolY; cl12025 381754000262 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 381754000263 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 381754000264 Catalytic site [active] 381754000265 putative transcriptional regulator MerR; Provisional; Region: PRK13752 381754000266 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 381754000267 DNA binding residues [nucleotide binding] 381754000268 dimer interface [polypeptide binding]; other site 381754000269 mercury binding site [ion binding]; other site 381754000270 putative mercuric transport protein; Provisional; Region: PRK13751 381754000271 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754000272 metal-binding site [ion binding] 381754000273 putative mercuric reductase; Provisional; Region: PRK13748 381754000274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754000275 metal-binding site [ion binding] 381754000276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754000277 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 381754000278 transcriptional regulator MerD; Provisional; Region: PRK13749 381754000279 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 381754000280 DNA binding residues [nucleotide binding] 381754000281 putative dimer interface [polypeptide binding]; other site 381754000282 putative mercury resistance protein; Provisional; Region: PRK13747 381754000283 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754000284 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 381754000285 multiple promoter invertase; Provisional; Region: mpi; PRK13413 381754000286 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 381754000287 catalytic residues [active] 381754000288 catalytic nucleophile [active] 381754000289 Presynaptic Site I dimer interface [polypeptide binding]; other site 381754000290 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 381754000291 Synaptic Flat tetramer interface [polypeptide binding]; other site 381754000292 Synaptic Site I dimer interface [polypeptide binding]; other site 381754000293 DNA binding site [nucleotide binding] 381754000294 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569 381754000295 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 381754000296 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 381754000297 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754000298 metal-binding site [ion binding] 381754000299 MerT mercuric transport protein; Region: MerT; cl03578 381754000300 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 381754000301 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 381754000302 DNA binding residues [nucleotide binding] 381754000303 dimer interface [polypeptide binding]; other site 381754000304 mercury binding site [ion binding]; other site 381754000305 Cupin; Region: Cupin_6; pfam12852 381754000306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754000307 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754000308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754000309 Protein of unknown function, DUF417; Region: DUF417; cl01162 381754000310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 381754000311 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 381754000312 GSH binding site [chemical binding]; other site 381754000313 catalytic residues [active] 381754000314 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 381754000315 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 381754000316 FAD binding pocket [chemical binding]; other site 381754000317 FAD binding motif [chemical binding]; other site 381754000318 phosphate binding motif [ion binding]; other site 381754000319 beta-alpha-beta structure motif; other site 381754000320 NAD binding pocket [chemical binding]; other site 381754000321 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 381754000322 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 381754000323 Moco binding site; other site 381754000324 metal coordination site [ion binding]; other site 381754000325 Domain of unknown function (DUF336); Region: DUF336; cl01249 381754000326 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 381754000327 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 381754000328 putative NAD(P) binding site [chemical binding]; other site 381754000329 dimer interface [polypeptide binding]; other site 381754000330 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 381754000331 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 381754000332 oligomer interface [polypeptide binding]; other site 381754000333 metal binding site [ion binding]; metal-binding site 381754000334 metal binding site [ion binding]; metal-binding site 381754000335 putative Cl binding site [ion binding]; other site 381754000336 basic sphincter; other site 381754000337 hydrophobic gate; other site 381754000338 periplasmic entrance; other site 381754000339 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 381754000340 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 381754000341 C-terminal domain interface [polypeptide binding]; other site 381754000342 GSH binding site (G-site) [chemical binding]; other site 381754000343 dimer interface [polypeptide binding]; other site 381754000344 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 381754000345 N-terminal domain interface [polypeptide binding]; other site 381754000346 dimer interface [polypeptide binding]; other site 381754000347 substrate binding pocket (H-site) [chemical binding]; other site 381754000348 methionine sulfoxide reductase A; Provisional; Region: PRK14054 381754000349 transposase/IS protein; Provisional; Region: PRK09183 381754000350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754000351 Walker A motif; other site 381754000352 ATP binding site [chemical binding]; other site 381754000353 Walker B motif; other site 381754000354 arginine finger; other site 381754000355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 381754000356 Integrase core domain; Region: rve; pfam00665 381754000357 Integrase core domain; Region: rve_3; pfam13683 381754000358 ThiF family; Region: ThiF; pfam00899 381754000359 ATP binding site [chemical binding]; other site 381754000360 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 381754000361 active site 381754000362 NTP binding site [chemical binding]; other site 381754000363 metal binding triad [ion binding]; metal-binding site 381754000364 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 381754000365 active site 381754000366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 381754000367 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 381754000368 Uncharacterized conserved protein [Function unknown]; Region: COG1262 381754000369 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 381754000370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 381754000371 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 381754000372 Walker A/P-loop; other site 381754000373 ATP binding site [chemical binding]; other site 381754000374 Q-loop/lid; other site 381754000375 ABC transporter signature motif; other site 381754000376 Walker B; other site 381754000377 D-loop; other site 381754000378 H-loop/switch region; other site 381754000379 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 381754000380 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 381754000381 active site 381754000382 ATP binding site [chemical binding]; other site 381754000383 substrate binding site [chemical binding]; other site 381754000384 activation loop (A-loop); other site 381754000385 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 381754000386 metal ion-dependent adhesion site (MIDAS); other site 381754000387 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 381754000388 active site 381754000389 Protein phosphatase 2C; Region: PP2C; pfam00481 381754000390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SciT; COG3913 381754000391 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 381754000392 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 381754000393 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 381754000394 hypothetical protein; Provisional; Region: PRK07033 381754000395 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 381754000396 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754000397 ligand binding site [chemical binding]; other site 381754000398 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 381754000399 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 381754000400 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 381754000401 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 381754000402 phosphopeptide binding site; other site 381754000403 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 381754000404 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 381754000405 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 381754000406 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 381754000407 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 381754000408 Protein of unknown function (DUF877); Region: DUF877; pfam05943 381754000409 Protein of unknown function (DUF796); Region: DUF796; pfam05638 381754000410 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 381754000411 ImpE protein; Region: ImpE; pfam07024 381754000412 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 381754000413 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 381754000414 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 381754000415 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 381754000416 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 381754000417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754000418 Walker A motif; other site 381754000419 ATP binding site [chemical binding]; other site 381754000420 Walker B motif; other site 381754000421 arginine finger; other site 381754000422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754000423 Walker A motif; other site 381754000424 ATP binding site [chemical binding]; other site 381754000425 Walker B motif; other site 381754000426 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 381754000427 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 381754000428 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 381754000429 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 381754000430 PAAR motif; Region: PAAR_motif; pfam05488 381754000431 Uncharacterized conserved protein [Function unknown]; Region: COG5435 381754000432 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 381754000433 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 381754000434 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 381754000435 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 381754000436 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 381754000437 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 381754000438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5351 381754000439 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 381754000440 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 381754000441 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 381754000442 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 381754000443 conserved hypothetical protein; Region: TIGR02270 381754000444 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 381754000445 active site clefts [active] 381754000446 zinc binding site [ion binding]; other site 381754000447 dimer interface [polypeptide binding]; other site 381754000448 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 381754000449 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 381754000450 Sulfate transporter family; Region: Sulfate_transp; pfam00916 381754000451 Sulfate transporter family; Region: Sulfate_transp; pfam00916 381754000452 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 381754000453 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 381754000454 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 381754000455 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 381754000456 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754000457 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754000458 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 381754000459 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 381754000460 Subunit I/III interface [polypeptide binding]; other site 381754000461 D-pathway; other site 381754000462 Subunit I/VIIc interface [polypeptide binding]; other site 381754000463 Subunit I/IV interface [polypeptide binding]; other site 381754000464 Subunit I/II interface [polypeptide binding]; other site 381754000465 Low-spin heme (heme a) binding site [chemical binding]; other site 381754000466 Subunit I/VIIa interface [polypeptide binding]; other site 381754000467 Subunit I/VIa interface [polypeptide binding]; other site 381754000468 Dimer interface; other site 381754000469 Putative water exit pathway; other site 381754000470 Binuclear center (heme a3/CuB) [ion binding]; other site 381754000471 K-pathway; other site 381754000472 Subunit I/Vb interface [polypeptide binding]; other site 381754000473 Putative proton exit pathway; other site 381754000474 Subunit I/VIb interface; other site 381754000475 Subunit I/VIc interface [polypeptide binding]; other site 381754000476 Electron transfer pathway; other site 381754000477 Subunit I/VIIIb interface [polypeptide binding]; other site 381754000478 Subunit I/VIIb interface [polypeptide binding]; other site 381754000479 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 381754000480 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 381754000481 Subunit III/VIIa interface [polypeptide binding]; other site 381754000482 Phospholipid binding site [chemical binding]; other site 381754000483 Subunit I/III interface [polypeptide binding]; other site 381754000484 Subunit III/VIb interface [polypeptide binding]; other site 381754000485 Subunit III/VIa interface; other site 381754000486 Subunit III/Vb interface [polypeptide binding]; other site 381754000487 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 381754000488 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 381754000489 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 381754000490 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 381754000491 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 381754000492 UbiA prenyltransferase family; Region: UbiA; pfam01040 381754000493 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 381754000494 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 381754000495 Cu(I) binding site [ion binding]; other site 381754000496 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 381754000497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754000498 Coenzyme A binding pocket [chemical binding]; other site 381754000499 Predicted transcriptional regulators [Transcription]; Region: COG1733 381754000500 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 381754000501 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 381754000502 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 381754000503 putative NAD(P) binding site [chemical binding]; other site 381754000504 active site 381754000505 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 381754000506 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 381754000507 putative catalytic residue [active] 381754000508 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 381754000509 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 381754000510 Transcriptional regulators [Transcription]; Region: FadR; COG2186 381754000511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754000512 DNA-binding site [nucleotide binding]; DNA binding site 381754000513 FCD domain; Region: FCD; pfam07729 381754000514 Transcriptional regulators [Transcription]; Region: GntR; COG1802 381754000515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 381754000516 DNA-binding site [nucleotide binding]; DNA binding site 381754000517 FCD domain; Region: FCD; pfam07729 381754000518 Aegerolysin; Region: Aegerolysin; pfam06355 381754000519 transcriptional regulator; Provisional; Region: PRK10632 381754000520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000521 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754000522 putative effector binding pocket; other site 381754000523 dimerization interface [polypeptide binding]; other site 381754000524 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 381754000525 Predicted transcriptional regulator [Transcription]; Region: COG3905 381754000526 Water Stress and Hypersensitive response; Region: WHy; smart00769 381754000527 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 381754000528 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 381754000529 PhnA protein; Region: PhnA; pfam03831 381754000530 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 381754000531 Spore germination protein; Region: Spore_permease; cl17796 381754000532 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 381754000533 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 381754000534 tetrameric interface [polypeptide binding]; other site 381754000535 NAD binding site [chemical binding]; other site 381754000536 catalytic residues [active] 381754000537 Cupin domain; Region: Cupin_2; cl17218 381754000538 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 381754000539 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754000540 inhibitor-cofactor binding pocket; inhibition site 381754000541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754000542 catalytic residue [active] 381754000543 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754000544 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000545 LysR substrate binding domain; Region: LysR_substrate; pfam03466 381754000546 dimerization interface [polypeptide binding]; other site 381754000547 guanine deaminase; Provisional; Region: PRK09228 381754000548 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 381754000549 active site 381754000550 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 381754000551 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 381754000552 Walker A/P-loop; other site 381754000553 ATP binding site [chemical binding]; other site 381754000554 Q-loop/lid; other site 381754000555 ABC transporter signature motif; other site 381754000556 Walker B; other site 381754000557 D-loop; other site 381754000558 H-loop/switch region; other site 381754000559 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 381754000560 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381754000561 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 381754000562 TM-ABC transporter signature motif; other site 381754000563 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381754000564 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 381754000565 TM-ABC transporter signature motif; other site 381754000566 peroxiredoxin; Region: AhpC; TIGR03137 381754000567 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 381754000568 dimer interface [polypeptide binding]; other site 381754000569 decamer (pentamer of dimers) interface [polypeptide binding]; other site 381754000570 catalytic triad [active] 381754000571 peroxidatic and resolving cysteines [active] 381754000572 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 381754000573 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 381754000574 catalytic residue [active] 381754000575 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 381754000576 catalytic residues [active] 381754000577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754000578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754000579 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 381754000580 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 381754000581 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 381754000582 active site 381754000583 putative substrate binding pocket [chemical binding]; other site 381754000584 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 381754000585 active site 381754000586 tetramer interface [polypeptide binding]; other site 381754000587 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 381754000588 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 381754000589 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 381754000590 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 381754000591 putative ligand binding site [chemical binding]; other site 381754000592 oxidase reductase; Provisional; Region: PTZ00273 381754000593 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 381754000594 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 381754000595 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 381754000596 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 381754000597 active site 381754000598 purine riboside binding site [chemical binding]; other site 381754000599 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 381754000600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754000601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754000602 DNA binding residues [nucleotide binding] 381754000603 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754000604 FecR protein; Region: FecR; pfam04773 381754000605 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754000606 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 381754000607 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754000608 N-terminal plug; other site 381754000609 ligand-binding site [chemical binding]; other site 381754000610 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 381754000611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754000613 dimerization interface [polypeptide binding]; other site 381754000614 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 381754000615 heterodimer interface [polypeptide binding]; other site 381754000616 multimer interface [polypeptide binding]; other site 381754000617 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 381754000618 active site 381754000619 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 381754000620 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 381754000621 heterodimer interface [polypeptide binding]; other site 381754000622 active site 381754000623 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 381754000624 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 381754000625 Bacterial transcriptional regulator; Region: IclR; pfam01614 381754000626 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754000627 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754000628 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754000629 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754000630 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754000631 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754000632 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 381754000633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754000634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000635 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754000636 putative effector binding pocket; other site 381754000637 dimerization interface [polypeptide binding]; other site 381754000638 outer membrane porin, OprD family; Region: OprD; pfam03573 381754000639 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754000640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754000641 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754000642 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 381754000643 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 381754000644 Nucleoside-binding outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: Tsx; COG3248 381754000645 xanthine permease; Region: pbuX; TIGR03173 381754000646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754000647 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 381754000648 Uncharacterized conserved protein [Function unknown]; Region: COG1739 381754000649 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 381754000650 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 381754000651 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754000652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754000653 metal binding site [ion binding]; metal-binding site 381754000654 active site 381754000655 I-site; other site 381754000656 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 381754000657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754000658 dimerization interface [polypeptide binding]; other site 381754000659 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 381754000660 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 381754000661 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 381754000662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754000663 active site 381754000664 phosphorylation site [posttranslational modification] 381754000665 intermolecular recognition site; other site 381754000666 dimerization interface [polypeptide binding]; other site 381754000667 CheB methylesterase; Region: CheB_methylest; pfam01339 381754000668 CheD chemotactic sensory transduction; Region: CheD; cl00810 381754000669 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 381754000670 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 381754000671 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 381754000672 PAS domain; Region: PAS; smart00091 381754000673 PAS domain; Region: PAS_9; pfam13426 381754000674 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754000675 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754000676 dimer interface [polypeptide binding]; other site 381754000677 putative CheW interface [polypeptide binding]; other site 381754000678 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 381754000679 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754000680 putative binding surface; other site 381754000681 active site 381754000682 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 381754000683 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 381754000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754000685 ATP binding site [chemical binding]; other site 381754000686 G-X-G motif; other site 381754000687 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 381754000688 Response regulator receiver domain; Region: Response_reg; pfam00072 381754000689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754000690 active site 381754000691 phosphorylation site [posttranslational modification] 381754000692 intermolecular recognition site; other site 381754000693 dimerization interface [polypeptide binding]; other site 381754000694 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 381754000695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754000696 putative CheW interface [polypeptide binding]; other site 381754000697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000699 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754000700 putative effector binding pocket; other site 381754000701 dimerization interface [polypeptide binding]; other site 381754000702 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 381754000703 classical (c) SDRs; Region: SDR_c; cd05233 381754000704 NAD(P) binding site [chemical binding]; other site 381754000705 active site 381754000706 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 381754000707 Sulfatase; Region: Sulfatase; pfam00884 381754000708 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 381754000709 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 381754000710 Walker A/P-loop; other site 381754000711 ATP binding site [chemical binding]; other site 381754000712 Q-loop/lid; other site 381754000713 ABC transporter signature motif; other site 381754000714 Walker B; other site 381754000715 D-loop; other site 381754000716 H-loop/switch region; other site 381754000717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 381754000718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 381754000719 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 381754000720 Uncharacterized protein family (UPF0254); Region: UPF0254; cl01641 381754000721 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 381754000722 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 381754000723 outer membrane porin, OprD family; Region: OprD; pfam03573 381754000724 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 381754000725 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 381754000726 active site 381754000727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754000728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754000730 dimerization interface [polypeptide binding]; other site 381754000731 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 381754000732 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754000733 N-terminal plug; other site 381754000734 ligand-binding site [chemical binding]; other site 381754000735 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 381754000736 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 381754000737 active site 381754000738 iron coordination sites [ion binding]; other site 381754000739 substrate binding pocket [chemical binding]; other site 381754000740 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 381754000741 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 381754000742 active site 381754000743 iron coordination sites [ion binding]; other site 381754000744 substrate binding pocket [chemical binding]; other site 381754000745 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 381754000746 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 381754000747 ligand binding site [chemical binding]; other site 381754000748 homodimer interface [polypeptide binding]; other site 381754000749 NAD(P) binding site [chemical binding]; other site 381754000750 trimer interface B [polypeptide binding]; other site 381754000751 trimer interface A [polypeptide binding]; other site 381754000752 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 381754000753 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 381754000754 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 381754000755 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 381754000756 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 381754000757 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 381754000758 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 381754000759 TolR protein; Region: tolR; TIGR02801 381754000760 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 381754000761 Serine hydrolase; Region: Ser_hydrolase; pfam06821 381754000762 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754000763 amidase; Provisional; Region: PRK07486 381754000764 Amidase; Region: Amidase; cl11426 381754000765 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381754000766 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 381754000767 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381754000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754000769 dimer interface [polypeptide binding]; other site 381754000770 conserved gate region; other site 381754000771 putative PBP binding loops; other site 381754000772 ABC-ATPase subunit interface; other site 381754000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754000774 dimer interface [polypeptide binding]; other site 381754000775 conserved gate region; other site 381754000776 putative PBP binding loops; other site 381754000777 ABC-ATPase subunit interface; other site 381754000778 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 381754000779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754000780 Walker A/P-loop; other site 381754000781 ATP binding site [chemical binding]; other site 381754000782 Q-loop/lid; other site 381754000783 ABC transporter signature motif; other site 381754000784 Walker B; other site 381754000785 D-loop; other site 381754000786 H-loop/switch region; other site 381754000787 TOBE domain; Region: TOBE_2; pfam08402 381754000788 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754000789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754000791 dimerization interface [polypeptide binding]; other site 381754000792 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 381754000793 Coenzyme A transferase; Region: CoA_trans; cl17247 381754000794 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 381754000795 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 381754000796 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 381754000797 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 381754000798 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 381754000799 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 381754000800 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 381754000801 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 381754000802 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 381754000803 Malonate transporter MadL subunit; Region: MadL; cl04273 381754000804 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 381754000805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754000806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000807 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 381754000808 putative dimerization interface [polypeptide binding]; other site 381754000809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754000810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000811 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 381754000812 putative substrate binding pocket [chemical binding]; other site 381754000813 dimerization interface [polypeptide binding]; other site 381754000814 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 381754000815 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 381754000816 NAD(P) binding site [chemical binding]; other site 381754000817 catalytic residues [active] 381754000818 amino acid transporter; Region: 2A0306; TIGR00909 381754000819 putative aminotransferase; Provisional; Region: PRK12403 381754000820 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754000821 inhibitor-cofactor binding pocket; inhibition site 381754000822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754000823 catalytic residue [active] 381754000824 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381754000825 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 381754000826 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 381754000827 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 381754000828 inhibitor site; inhibition site 381754000829 active site 381754000830 dimer interface [polypeptide binding]; other site 381754000831 catalytic residue [active] 381754000832 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 381754000833 intersubunit interface [polypeptide binding]; other site 381754000834 active site 381754000835 Zn2+ binding site [ion binding]; other site 381754000836 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754000837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754000838 sequence-specific DNA binding site [nucleotide binding]; other site 381754000839 salt bridge; other site 381754000840 Cupin domain; Region: Cupin_2; pfam07883 381754000841 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 381754000842 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 381754000843 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 381754000844 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754000845 dimer interface [polypeptide binding]; other site 381754000846 active site 381754000847 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 381754000848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754000849 putative substrate translocation pore; other site 381754000850 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 381754000851 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 381754000852 tetramer interface [polypeptide binding]; other site 381754000853 active site 381754000854 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 381754000855 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 381754000856 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 381754000857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754000858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754000859 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754000860 dimerization interface [polypeptide binding]; other site 381754000861 benzoate transport; Region: 2A0115; TIGR00895 381754000862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754000863 putative substrate translocation pore; other site 381754000864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754000865 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 381754000866 EamA-like transporter family; Region: EamA; pfam00892 381754000867 outer membrane porin, OprD family; Region: OprD; pfam03573 381754000868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754000869 D-galactonate transporter; Region: 2A0114; TIGR00893 381754000870 putative substrate translocation pore; other site 381754000871 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 381754000872 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 381754000873 dimer interface [polypeptide binding]; other site 381754000874 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 381754000875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754000876 active site 381754000877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754000878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754000879 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 381754000880 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 381754000881 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 381754000882 shikimate binding site; other site 381754000883 NAD(P) binding site [chemical binding]; other site 381754000884 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 381754000885 Dehydroquinase class II; Region: DHquinase_II; pfam01220 381754000886 active site 381754000887 trimer interface [polypeptide binding]; other site 381754000888 dimer interface [polypeptide binding]; other site 381754000889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754000890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754000891 putative substrate translocation pore; other site 381754000892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754000893 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 381754000894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381754000895 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 381754000896 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754000897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754000898 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 381754000899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754000900 Coenzyme A binding pocket [chemical binding]; other site 381754000901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 381754000902 FOG: CBS domain [General function prediction only]; Region: COG0517 381754000903 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 381754000904 MarR family; Region: MarR_2; cl17246 381754000905 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 381754000906 Predicted membrane protein [Function unknown]; Region: COG3619 381754000907 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 381754000908 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 381754000909 tetramerization interface [polypeptide binding]; other site 381754000910 NAD(P) binding site [chemical binding]; other site 381754000911 catalytic residues [active] 381754000912 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 381754000913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754000914 inhibitor-cofactor binding pocket; inhibition site 381754000915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754000916 catalytic residue [active] 381754000917 Response regulator receiver domain; Region: Response_reg; pfam00072 381754000918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754000919 active site 381754000920 phosphorylation site [posttranslational modification] 381754000921 intermolecular recognition site; other site 381754000922 dimerization interface [polypeptide binding]; other site 381754000923 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 381754000924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754000925 DNA-binding site [nucleotide binding]; DNA binding site 381754000926 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754000927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754000928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754000929 homodimer interface [polypeptide binding]; other site 381754000930 catalytic residue [active] 381754000931 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 381754000932 Uncharacterized conserved protein [Function unknown]; Region: COG2128 381754000933 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 381754000934 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 381754000935 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 381754000936 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 381754000937 ligand binding site [chemical binding]; other site 381754000938 flexible hinge region; other site 381754000939 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 381754000940 Predicted membrane protein [Function unknown]; Region: COG4539 381754000941 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 381754000942 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 381754000943 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 381754000944 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 381754000945 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 381754000946 Domain of unknown function (DUF927); Region: DUF927; cl12098 381754000947 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 381754000948 CHC2 zinc finger; Region: zf-CHC2; cl17510 381754000949 hypothetical protein; Provisional; Region: PRK09946 381754000950 Helix-turn-helix domain; Region: HTH_17; pfam12728 381754000951 Helix-turn-helix domain; Region: HTH_17; pfam12728 381754000952 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754000953 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 381754000954 active site 381754000955 DNA binding site [nucleotide binding] 381754000956 Int/Topo IB signature motif; other site 381754000957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754000958 dimerization interface [polypeptide binding]; other site 381754000959 putative DNA binding site [nucleotide binding]; other site 381754000960 putative Zn2+ binding site [ion binding]; other site 381754000961 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 381754000962 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 381754000963 Walker A/P-loop; other site 381754000964 ATP binding site [chemical binding]; other site 381754000965 Q-loop/lid; other site 381754000966 ABC transporter signature motif; other site 381754000967 Walker B; other site 381754000968 D-loop; other site 381754000969 H-loop/switch region; other site 381754000970 TOBE-like domain; Region: TOBE_3; pfam12857 381754000971 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 381754000972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754000973 dimer interface [polypeptide binding]; other site 381754000974 conserved gate region; other site 381754000975 putative PBP binding loops; other site 381754000976 ABC-ATPase subunit interface; other site 381754000977 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 381754000978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754000979 dimer interface [polypeptide binding]; other site 381754000980 conserved gate region; other site 381754000981 putative PBP binding loops; other site 381754000982 ABC-ATPase subunit interface; other site 381754000983 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 381754000984 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 381754000985 Uncharacterized small protein [Function unknown]; Region: COG5583 381754000986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754000987 PAS fold; Region: PAS_3; pfam08447 381754000988 putative active site [active] 381754000989 heme pocket [chemical binding]; other site 381754000990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754000991 PAS domain; Region: PAS_9; pfam13426 381754000992 putative active site [active] 381754000993 heme pocket [chemical binding]; other site 381754000994 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754000995 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754000996 metal binding site [ion binding]; metal-binding site 381754000997 active site 381754000998 I-site; other site 381754000999 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754001000 Fatty acid desaturase; Region: FA_desaturase; pfam00487 381754001001 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 381754001002 Di-iron ligands [ion binding]; other site 381754001003 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 381754001004 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381754001005 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 381754001006 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 381754001007 Na binding site [ion binding]; other site 381754001008 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 381754001009 agmatinase; Region: agmatinase; TIGR01230 381754001010 oligomer interface [polypeptide binding]; other site 381754001011 putative active site [active] 381754001012 Mn binding site [ion binding]; other site 381754001013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754001014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754001015 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754001016 dimerization interface [polypeptide binding]; other site 381754001017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754001018 PAS fold; Region: PAS_3; pfam08447 381754001019 putative active site [active] 381754001020 heme pocket [chemical binding]; other site 381754001021 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754001022 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754001023 metal binding site [ion binding]; metal-binding site 381754001024 active site 381754001025 I-site; other site 381754001026 outer membrane porin, OprD family; Region: OprD; pfam03573 381754001027 agmatine deiminase; Provisional; Region: PRK13551 381754001028 agmatine deiminase; Region: agmatine_aguA; TIGR03380 381754001029 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 381754001030 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 381754001031 putative active site; other site 381754001032 catalytic triad [active] 381754001033 putative dimer interface [polypeptide binding]; other site 381754001034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754001035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754001036 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381754001037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754001038 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754001039 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 381754001040 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 381754001041 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381754001042 Peptidase C26; Region: Peptidase_C26; pfam07722 381754001043 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 381754001044 catalytic triad [active] 381754001045 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 381754001046 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381754001047 putative aminotransferase; Validated; Region: PRK07480 381754001048 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754001049 inhibitor-cofactor binding pocket; inhibition site 381754001050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754001051 catalytic residue [active] 381754001052 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 381754001053 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754001054 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 381754001055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754001056 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 381754001057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754001058 Walker A/P-loop; other site 381754001059 ATP binding site [chemical binding]; other site 381754001060 Q-loop/lid; other site 381754001061 ABC transporter signature motif; other site 381754001062 Walker B; other site 381754001063 D-loop; other site 381754001064 H-loop/switch region; other site 381754001065 TOBE domain; Region: TOBE_2; pfam08402 381754001066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754001067 dimer interface [polypeptide binding]; other site 381754001068 conserved gate region; other site 381754001069 putative PBP binding loops; other site 381754001070 ABC-ATPase subunit interface; other site 381754001071 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381754001072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754001073 dimer interface [polypeptide binding]; other site 381754001074 conserved gate region; other site 381754001075 putative PBP binding loops; other site 381754001076 ABC-ATPase subunit interface; other site 381754001077 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 381754001078 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 381754001079 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 381754001080 active site 381754001081 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754001082 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754001083 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 381754001084 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 381754001085 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754001086 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 381754001087 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 381754001088 Uncharacterized conserved protein [Function unknown]; Region: COG1683 381754001089 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381754001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754001091 dimer interface [polypeptide binding]; other site 381754001092 conserved gate region; other site 381754001093 putative PBP binding loops; other site 381754001094 ABC-ATPase subunit interface; other site 381754001095 cystine transporter subunit; Provisional; Region: PRK11260 381754001096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754001097 substrate binding pocket [chemical binding]; other site 381754001098 membrane-bound complex binding site; other site 381754001099 hinge residues; other site 381754001100 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 381754001101 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 381754001102 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 381754001103 ligand binding site [chemical binding]; other site 381754001104 NAD binding site [chemical binding]; other site 381754001105 tetramer interface [polypeptide binding]; other site 381754001106 catalytic site [active] 381754001107 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 381754001108 L-serine binding site [chemical binding]; other site 381754001109 ACT domain interface; other site 381754001110 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 381754001111 FAD binding domain; Region: FAD_binding_4; pfam01565 381754001112 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 381754001113 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 381754001114 SdiA-regulated; Region: SdiA-regulated; pfam06977 381754001115 SdiA-regulated; Region: SdiA-regulated; cd09971 381754001116 putative active site [active] 381754001117 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 381754001118 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 381754001119 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 381754001120 active site 381754001121 Zn binding site [ion binding]; other site 381754001122 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 381754001123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 381754001124 SdiA-regulated; Region: SdiA-regulated; cd09971 381754001125 putative active site [active] 381754001126 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 381754001127 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 381754001128 metal binding site [ion binding]; metal-binding site 381754001129 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 381754001130 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 381754001131 trimer interface [polypeptide binding]; other site 381754001132 active site 381754001133 substrate binding site [chemical binding]; other site 381754001134 CoA binding site [chemical binding]; other site 381754001135 Uncharacterized conserved protein [Function unknown]; Region: COG3422 381754001136 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 381754001137 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 381754001138 tetramer (dimer of dimers) interface [polypeptide binding]; other site 381754001139 active site 381754001140 dimer interface [polypeptide binding]; other site 381754001141 threonine dehydratase; Reviewed; Region: PRK09224 381754001142 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 381754001143 tetramer interface [polypeptide binding]; other site 381754001144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754001145 catalytic residue [active] 381754001146 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 381754001147 putative Ile/Val binding site [chemical binding]; other site 381754001148 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 381754001149 putative Ile/Val binding site [chemical binding]; other site 381754001150 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 381754001151 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 381754001152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754001153 NAD(P) binding site [chemical binding]; other site 381754001154 active site 381754001155 DoxX-like family; Region: DoxX_3; pfam13781 381754001156 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 381754001157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754001158 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754001159 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 381754001160 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 381754001161 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 381754001162 putative active site [active] 381754001163 Ap4A binding site [chemical binding]; other site 381754001164 nudix motif; other site 381754001165 putative metal binding site [ion binding]; other site 381754001166 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 381754001167 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 381754001168 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 381754001169 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 381754001170 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 381754001171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754001172 PAS fold; Region: PAS_3; pfam08447 381754001173 putative active site [active] 381754001174 heme pocket [chemical binding]; other site 381754001175 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754001176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754001177 metal binding site [ion binding]; metal-binding site 381754001178 active site 381754001179 I-site; other site 381754001180 Uncharacterized conserved protein [Function unknown]; Region: COG3332 381754001181 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 381754001182 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 381754001183 thymidylate synthase; Reviewed; Region: thyA; PRK01827 381754001184 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 381754001185 dimerization interface [polypeptide binding]; other site 381754001186 active site 381754001187 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381754001188 G1 box; other site 381754001189 GTP/Mg2+ binding site [chemical binding]; other site 381754001190 G2 box; other site 381754001191 Switch I region; other site 381754001192 G3 box; other site 381754001193 Switch II region; other site 381754001194 G4 box; other site 381754001195 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 381754001196 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 381754001197 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 381754001198 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 381754001199 putative active site [active] 381754001200 catalytic site [active] 381754001201 putative metal binding site [ion binding]; other site 381754001202 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 381754001203 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 381754001204 folate binding site [chemical binding]; other site 381754001205 NADP+ binding site [chemical binding]; other site 381754001206 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 381754001207 active site 381754001208 metal binding site [ion binding]; metal-binding site 381754001209 homotetramer interface [polypeptide binding]; other site 381754001210 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 381754001211 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 381754001212 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 381754001213 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 381754001214 putative RNA binding site [nucleotide binding]; other site 381754001215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754001216 S-adenosylmethionine binding site [chemical binding]; other site 381754001217 intracellular protease, PfpI family; Region: PfpI; TIGR01382 381754001218 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 381754001219 proposed catalytic triad [active] 381754001220 conserved cys residue [active] 381754001221 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 381754001222 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 381754001223 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 381754001224 DNA binding site [nucleotide binding] 381754001225 catalytic residue [active] 381754001226 H2TH interface [polypeptide binding]; other site 381754001227 putative catalytic residues [active] 381754001228 turnover-facilitating residue; other site 381754001229 intercalation triad [nucleotide binding]; other site 381754001230 8OG recognition residue [nucleotide binding]; other site 381754001231 putative reading head residues; other site 381754001232 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 381754001233 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 381754001234 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 381754001235 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 381754001236 putative acyl-acceptor binding pocket; other site 381754001237 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 381754001238 Sel1-like repeats; Region: SEL1; smart00671 381754001239 Sel1-like repeats; Region: SEL1; smart00671 381754001240 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 381754001241 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 381754001242 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 381754001243 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 381754001244 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 381754001245 active site 381754001246 (T/H)XGH motif; other site 381754001247 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 381754001248 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 381754001249 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 381754001250 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 381754001251 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 381754001252 NAD(P) binding site [chemical binding]; other site 381754001253 catalytic residues [active] 381754001254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754001255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754001256 Bacterial transcriptional repressor; Region: TetR; pfam13972 381754001257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754001258 Coenzyme A binding pocket [chemical binding]; other site 381754001259 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 381754001260 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 381754001261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754001262 S-adenosylmethionine binding site [chemical binding]; other site 381754001263 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 381754001264 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 381754001265 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 381754001266 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 381754001267 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 381754001268 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 381754001269 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 381754001270 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 381754001271 P loop; other site 381754001272 GTP binding site [chemical binding]; other site 381754001273 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 381754001274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754001275 Walker A/P-loop; other site 381754001276 ATP binding site [chemical binding]; other site 381754001277 Q-loop/lid; other site 381754001278 ABC transporter signature motif; other site 381754001279 Walker B; other site 381754001280 D-loop; other site 381754001281 H-loop/switch region; other site 381754001282 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 381754001283 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 381754001284 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 381754001285 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 381754001286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754001287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754001288 DNA binding residues [nucleotide binding] 381754001289 Transposase; Region: HTH_Tnp_1; pfam01527 381754001290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381754001291 HTH-like domain; Region: HTH_21; pfam13276 381754001292 Integrase core domain; Region: rve; pfam00665 381754001293 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 381754001294 Beta-lactamase; Region: Beta-lactamase; pfam00144 381754001295 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 381754001296 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 381754001297 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 381754001298 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 381754001299 monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070 381754001300 Protein of unknown function (DUF423); Region: DUF423; pfam04241 381754001301 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 381754001302 thiS-thiF/thiG interaction site; other site 381754001303 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 381754001304 ThiS interaction site; other site 381754001305 putative active site [active] 381754001306 tetramer interface [polypeptide binding]; other site 381754001307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754001308 S-adenosylmethionine binding site [chemical binding]; other site 381754001309 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 381754001310 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 381754001311 HemN family oxidoreductase; Provisional; Region: PRK05660 381754001312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754001313 FeS/SAM binding site; other site 381754001314 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 381754001315 active site 381754001316 dimerization interface [polypeptide binding]; other site 381754001317 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 381754001318 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754001319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754001320 S-adenosylmethionine binding site [chemical binding]; other site 381754001321 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 381754001322 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 381754001323 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381754001324 G1 box; other site 381754001325 GTP/Mg2+ binding site [chemical binding]; other site 381754001326 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 381754001327 G2 box; other site 381754001328 Switch I region; other site 381754001329 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 381754001330 G3 box; other site 381754001331 Switch II region; other site 381754001332 GTP/Mg2+ binding site [chemical binding]; other site 381754001333 G4 box; other site 381754001334 G5 box; other site 381754001335 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 381754001336 YGGT family; Region: YGGT; pfam02325 381754001337 YGGT family; Region: YGGT; pfam02325 381754001338 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 381754001339 pyrroline-5-carboxylate reductase; Region: PLN02688 381754001340 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 381754001341 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381754001342 catalytic residue [active] 381754001343 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 381754001344 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 381754001345 Walker A motif; other site 381754001346 ATP binding site [chemical binding]; other site 381754001347 Walker B motif; other site 381754001348 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 381754001349 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 381754001350 Walker A motif; other site 381754001351 ATP binding site [chemical binding]; other site 381754001352 Walker B motif; other site 381754001353 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 381754001354 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 381754001355 TM2 domain; Region: TM2; cl00984 381754001356 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 381754001357 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 381754001358 dimer interface [polypeptide binding]; other site 381754001359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754001360 catalytic residue [active] 381754001361 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 381754001362 FOG: CBS domain [General function prediction only]; Region: COG0517 381754001363 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 381754001364 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 381754001365 homodimer interface [polypeptide binding]; other site 381754001366 substrate-cofactor binding pocket; other site 381754001367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754001368 catalytic residue [active] 381754001369 dihydroorotase; Validated; Region: pyrC; PRK09357 381754001370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 381754001371 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 381754001372 active site 381754001373 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 381754001374 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 381754001375 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 381754001376 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 381754001377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754001378 active site 381754001379 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 381754001380 hypothetical protein; Validated; Region: PRK00228 381754001381 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 381754001382 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 381754001383 glutathione synthetase; Provisional; Region: PRK05246 381754001384 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 381754001385 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 381754001386 Response regulator receiver domain; Region: Response_reg; pfam00072 381754001387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754001388 active site 381754001389 phosphorylation site [posttranslational modification] 381754001390 intermolecular recognition site; other site 381754001391 dimerization interface [polypeptide binding]; other site 381754001392 Response regulator receiver domain; Region: Response_reg; pfam00072 381754001393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754001394 active site 381754001395 phosphorylation site [posttranslational modification] 381754001396 intermolecular recognition site; other site 381754001397 dimerization interface [polypeptide binding]; other site 381754001398 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 381754001399 putative CheA interaction surface; other site 381754001400 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 381754001401 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754001402 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754001403 dimer interface [polypeptide binding]; other site 381754001404 putative CheW interface [polypeptide binding]; other site 381754001405 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 381754001406 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 381754001407 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 381754001408 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754001409 putative binding surface; other site 381754001410 active site 381754001411 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754001412 putative binding surface; other site 381754001413 active site 381754001414 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754001415 putative binding surface; other site 381754001416 active site 381754001417 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754001418 putative binding surface; other site 381754001419 active site 381754001420 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754001421 putative binding surface; other site 381754001422 active site 381754001423 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 381754001424 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 381754001425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754001426 ATP binding site [chemical binding]; other site 381754001427 Mg2+ binding site [ion binding]; other site 381754001428 G-X-G motif; other site 381754001429 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 381754001430 Response regulator receiver domain; Region: Response_reg; pfam00072 381754001431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754001432 active site 381754001433 phosphorylation site [posttranslational modification] 381754001434 intermolecular recognition site; other site 381754001435 dimerization interface [polypeptide binding]; other site 381754001436 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 381754001437 CheB methylesterase; Region: CheB_methylest; pfam01339 381754001438 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 381754001439 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754001440 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754001441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754001442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754001443 LysE type translocator; Region: LysE; pfam01810 381754001444 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 381754001445 RNA methyltransferase, RsmE family; Region: TIGR00046 381754001446 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 381754001447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754001448 inhibitor-cofactor binding pocket; inhibition site 381754001449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754001450 catalytic residue [active] 381754001451 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 381754001452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754001453 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 381754001454 hypothetical protein; Provisional; Region: PRK03757 381754001455 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 381754001456 MarR family; Region: MarR; pfam01047 381754001457 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 381754001458 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754001459 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754001460 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 381754001461 Protein export membrane protein; Region: SecD_SecF; cl14618 381754001462 Protein export membrane protein; Region: SecD_SecF; cl14618 381754001463 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 381754001464 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 381754001465 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 381754001466 ATP binding site [chemical binding]; other site 381754001467 Mg++ binding site [ion binding]; other site 381754001468 motif III; other site 381754001469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754001470 nucleotide binding region [chemical binding]; other site 381754001471 ATP-binding site [chemical binding]; other site 381754001472 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 381754001473 FAD binding site [chemical binding]; other site 381754001474 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 381754001475 HD domain; Region: HD_4; pfam13328 381754001476 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 381754001477 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 381754001478 homotetramer interface [polypeptide binding]; other site 381754001479 ligand binding site [chemical binding]; other site 381754001480 catalytic site [active] 381754001481 NAD binding site [chemical binding]; other site 381754001482 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 381754001483 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 381754001484 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754001485 N-terminal plug; other site 381754001486 ligand-binding site [chemical binding]; other site 381754001487 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 381754001488 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 381754001489 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 381754001490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754001491 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 381754001492 cytosine deaminase; Provisional; Region: PRK09230 381754001493 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 381754001494 active site 381754001495 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 381754001496 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 381754001497 Na binding site [ion binding]; other site 381754001498 putative substrate binding site [chemical binding]; other site 381754001499 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 381754001500 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 381754001501 homodimer interface [polypeptide binding]; other site 381754001502 active site 381754001503 FMN binding site [chemical binding]; other site 381754001504 substrate binding site [chemical binding]; other site 381754001505 4Fe-4S binding domain; Region: Fer4_6; pfam12837 381754001506 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 381754001507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381754001508 phenylhydantoinase; Validated; Region: PRK08323 381754001509 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 381754001510 tetramer interface [polypeptide binding]; other site 381754001511 active site 381754001512 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 381754001513 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 381754001514 Na binding site [ion binding]; other site 381754001515 putative substrate binding site [chemical binding]; other site 381754001516 allantoate amidohydrolase; Reviewed; Region: PRK09290 381754001517 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 381754001518 active site 381754001519 metal binding site [ion binding]; metal-binding site 381754001520 dimer interface [polypeptide binding]; other site 381754001521 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 381754001522 CoA-transferase family III; Region: CoA_transf_3; pfam02515 381754001523 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 381754001524 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754001525 FAD binding site [chemical binding]; other site 381754001526 substrate binding pocket [chemical binding]; other site 381754001527 catalytic base [active] 381754001528 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754001529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754001530 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 381754001531 dimerization interface [polypeptide binding]; other site 381754001532 substrate binding pocket [chemical binding]; other site 381754001533 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 381754001534 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381754001535 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 381754001536 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381754001537 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 381754001538 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 381754001539 dimer interface [polypeptide binding]; other site 381754001540 active site residues [active] 381754001541 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 381754001542 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 381754001543 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 381754001544 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754001545 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754001546 substrate binding pocket [chemical binding]; other site 381754001547 membrane-bound complex binding site; other site 381754001548 hinge residues; other site 381754001549 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 381754001550 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 381754001551 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 381754001552 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 381754001553 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 381754001554 ATP binding site [chemical binding]; other site 381754001555 Mg++ binding site [ion binding]; other site 381754001556 motif III; other site 381754001557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754001558 nucleotide binding region [chemical binding]; other site 381754001559 ATP-binding site [chemical binding]; other site 381754001560 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 381754001561 putative RNA binding site [nucleotide binding]; other site 381754001562 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 381754001563 DNA-binding site [nucleotide binding]; DNA binding site 381754001564 RNA-binding motif; other site 381754001565 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 381754001566 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 381754001567 putative transporter; Provisional; Region: PRK10504 381754001568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754001569 putative substrate translocation pore; other site 381754001570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754001571 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 381754001572 Clp amino terminal domain; Region: Clp_N; pfam02861 381754001573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754001574 Walker A motif; other site 381754001575 ATP binding site [chemical binding]; other site 381754001576 Walker B motif; other site 381754001577 arginine finger; other site 381754001578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754001579 Walker A motif; other site 381754001580 ATP binding site [chemical binding]; other site 381754001581 Walker B motif; other site 381754001582 arginine finger; other site 381754001583 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 381754001584 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 381754001585 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 381754001586 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 381754001587 putative acyl-acceptor binding pocket; other site 381754001588 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 381754001589 DNA-binding response regulator CreB; Provisional; Region: PRK11083 381754001590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754001591 active site 381754001592 phosphorylation site [posttranslational modification] 381754001593 intermolecular recognition site; other site 381754001594 dimerization interface [polypeptide binding]; other site 381754001595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754001596 DNA binding site [nucleotide binding] 381754001597 sensory histidine kinase CreC; Provisional; Region: PRK11100 381754001598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754001599 dimer interface [polypeptide binding]; other site 381754001600 phosphorylation site [posttranslational modification] 381754001601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754001602 ATP binding site [chemical binding]; other site 381754001603 G-X-G motif; other site 381754001604 Inner membrane protein CreD; Region: CreD; cl01844 381754001605 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754001606 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 381754001607 putative C-terminal domain interface [polypeptide binding]; other site 381754001608 putative GSH binding site (G-site) [chemical binding]; other site 381754001609 putative dimer interface [polypeptide binding]; other site 381754001610 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 381754001611 N-terminal domain interface [polypeptide binding]; other site 381754001612 dimer interface [polypeptide binding]; other site 381754001613 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 381754001614 Protein phosphatase 2C; Region: PP2C_2; pfam13672 381754001615 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754001616 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 381754001617 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754001618 N-terminal plug; other site 381754001619 ligand-binding site [chemical binding]; other site 381754001620 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754001621 FecR protein; Region: FecR; pfam04773 381754001622 RNA polymerase sigma factor; Reviewed; Region: PRK12523 381754001623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754001624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754001625 DNA binding residues [nucleotide binding] 381754001626 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754001627 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 381754001628 C-terminal domain interface [polypeptide binding]; other site 381754001629 GSH binding site (G-site) [chemical binding]; other site 381754001630 dimer interface [polypeptide binding]; other site 381754001631 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 381754001632 N-terminal domain interface [polypeptide binding]; other site 381754001633 dimer interface [polypeptide binding]; other site 381754001634 substrate binding pocket (H-site) [chemical binding]; other site 381754001635 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754001636 CoenzymeA binding site [chemical binding]; other site 381754001637 subunit interaction site [polypeptide binding]; other site 381754001638 PHB binding site; other site 381754001639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754001640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754001641 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 381754001642 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 381754001643 Na binding site [ion binding]; other site 381754001644 putative substrate binding site [chemical binding]; other site 381754001645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754001646 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 381754001647 putative substrate binding pocket [chemical binding]; other site 381754001648 dimerization interface [polypeptide binding]; other site 381754001649 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 381754001650 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 381754001651 active site 381754001652 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 381754001653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754001654 Coenzyme A binding pocket [chemical binding]; other site 381754001655 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 381754001656 ACT domain; Region: ACT_6; pfam13740 381754001657 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 381754001658 Predicted permeases [General function prediction only]; Region: RarD; COG2962 381754001659 EamA-like transporter family; Region: EamA; pfam00892 381754001660 serine/threonine protein kinase; Provisional; Region: PRK11768 381754001661 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 381754001662 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 381754001663 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 381754001664 TOBE domain; Region: TOBE; cl01440 381754001665 TOBE domain; Region: TOBE; cl01440 381754001666 lipoprotein; Provisional; Region: PRK10759 381754001667 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 381754001668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754001669 active site 381754001670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754001671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754001672 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 381754001673 putative substrate binding pocket [chemical binding]; other site 381754001674 dimerization interface [polypeptide binding]; other site 381754001675 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 381754001676 putative active site [active] 381754001677 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 381754001678 carboxyltransferase (CT) interaction site; other site 381754001679 biotinylation site [posttranslational modification]; other site 381754001680 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 381754001681 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 381754001682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754001683 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 381754001684 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 381754001685 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 381754001686 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 381754001687 biotin synthase; Provisional; Region: PRK15108 381754001688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754001689 FeS/SAM binding site; other site 381754001690 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 381754001691 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 381754001692 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 381754001693 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754001694 catalytic residue [active] 381754001695 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754001696 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 381754001697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754001698 S-adenosylmethionine binding site [chemical binding]; other site 381754001699 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 381754001700 AAA domain; Region: AAA_26; pfam13500 381754001701 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 381754001702 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 381754001703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754001704 active site 381754001705 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 381754001706 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 381754001707 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 381754001708 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754001709 active site 381754001710 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 381754001711 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 381754001712 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 381754001713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754001714 active site 381754001715 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 381754001716 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754001717 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754001718 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 381754001719 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 381754001720 structural tetrad; other site 381754001721 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 381754001722 active site 381754001723 SAM binding site [chemical binding]; other site 381754001724 homodimer interface [polypeptide binding]; other site 381754001725 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 381754001726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754001727 FeS/SAM binding site; other site 381754001728 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754001729 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754001730 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754001731 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754001732 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 381754001733 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754001734 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754001735 Cytochrome c; Region: Cytochrom_C; cl11414 381754001736 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754001737 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754001738 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 381754001739 MoxR-like ATPases [General function prediction only]; Region: COG0714 381754001740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754001741 Walker A motif; other site 381754001742 ATP binding site [chemical binding]; other site 381754001743 Walker B motif; other site 381754001744 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 381754001745 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 381754001746 Subunit I/III interface [polypeptide binding]; other site 381754001747 Cytochrome c; Region: Cytochrom_C; pfam00034 381754001748 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 381754001749 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 381754001750 Low-spin heme binding site [chemical binding]; other site 381754001751 D-pathway; other site 381754001752 Putative water exit pathway; other site 381754001753 Binuclear center (active site) [active] 381754001754 K-pathway; other site 381754001755 Putative proton exit pathway; other site 381754001756 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 381754001757 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 381754001758 metal ion-dependent adhesion site (MIDAS); other site 381754001759 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 381754001760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 381754001761 ligand binding site [chemical binding]; other site 381754001762 flexible hinge region; other site 381754001763 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 381754001764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754001765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754001766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754001767 dimerization interface [polypeptide binding]; other site 381754001768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 381754001769 MOSC domain; Region: MOSC; pfam03473 381754001770 3-alpha domain; Region: 3-alpha; pfam03475 381754001771 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 381754001772 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754001773 inhibitor-cofactor binding pocket; inhibition site 381754001774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754001775 catalytic residue [active] 381754001776 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 381754001777 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 381754001778 catalytic triad [active] 381754001779 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 381754001780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754001781 putative active site [active] 381754001782 heme pocket [chemical binding]; other site 381754001783 PAS domain S-box; Region: sensory_box; TIGR00229 381754001784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754001785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754001786 DNA binding residues [nucleotide binding] 381754001787 dimerization interface [polypeptide binding]; other site 381754001788 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754001789 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754001790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754001791 non-specific DNA binding site [nucleotide binding]; other site 381754001792 salt bridge; other site 381754001793 sequence-specific DNA binding site [nucleotide binding]; other site 381754001794 Cupin domain; Region: Cupin_2; pfam07883 381754001795 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 381754001796 Repair protein; Region: Repair_PSII; pfam04536 381754001797 LemA family; Region: LemA; pfam04011 381754001798 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 381754001799 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 381754001800 EamA-like transporter family; Region: EamA; cl17759 381754001801 Predicted membrane protein [Function unknown]; Region: COG3686 381754001802 Cytochrome c556 [Energy production and conversion]; Region: COG3909 381754001803 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 381754001804 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 381754001805 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381754001806 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 381754001807 putative active site [active] 381754001808 putative metal binding site [ion binding]; other site 381754001809 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 381754001810 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 381754001811 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 381754001812 FAD binding pocket [chemical binding]; other site 381754001813 FAD binding motif [chemical binding]; other site 381754001814 phosphate binding motif [ion binding]; other site 381754001815 beta-alpha-beta structure motif; other site 381754001816 NAD binding pocket [chemical binding]; other site 381754001817 S-adenosylmethionine synthetase; Validated; Region: PRK05250 381754001818 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 381754001819 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 381754001820 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 381754001821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754001822 putative DNA binding site [nucleotide binding]; other site 381754001823 dimerization interface [polypeptide binding]; other site 381754001824 putative Zn2+ binding site [ion binding]; other site 381754001825 Methyltransferase domain; Region: Methyltransf_23; pfam13489 381754001826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754001827 S-adenosylmethionine binding site [chemical binding]; other site 381754001828 transketolase; Reviewed; Region: PRK12753 381754001829 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 381754001830 TPP-binding site [chemical binding]; other site 381754001831 dimer interface [polypeptide binding]; other site 381754001832 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 381754001833 PYR/PP interface [polypeptide binding]; other site 381754001834 dimer interface [polypeptide binding]; other site 381754001835 TPP binding site [chemical binding]; other site 381754001836 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 381754001837 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 381754001838 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 381754001839 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 381754001840 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 381754001841 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 381754001842 Phosphoglycerate kinase; Region: PGK; pfam00162 381754001843 substrate binding site [chemical binding]; other site 381754001844 hinge regions; other site 381754001845 ADP binding site [chemical binding]; other site 381754001846 catalytic site [active] 381754001847 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 381754001848 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 381754001849 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 381754001850 intersubunit interface [polypeptide binding]; other site 381754001851 active site 381754001852 zinc binding site [ion binding]; other site 381754001853 Na+ binding site [ion binding]; other site 381754001854 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 381754001855 SnoaL-like domain; Region: SnoaL_3; pfam13474 381754001856 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754001857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754001858 S-adenosylmethionine binding site [chemical binding]; other site 381754001859 Predicted flavoproteins [General function prediction only]; Region: COG2081 381754001860 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 381754001861 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381754001862 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 381754001863 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 381754001864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754001865 motif II; other site 381754001866 Protein of unknown function (DUF805); Region: DUF805; pfam05656 381754001867 Cupin; Region: Cupin_6; pfam12852 381754001868 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754001869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754001870 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 381754001871 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 381754001872 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 381754001873 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 381754001874 Peptidase M60-like family; Region: M60-like; pfam13402 381754001875 Fic family protein [Function unknown]; Region: COG3177 381754001876 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 381754001877 Fic/DOC family; Region: Fic; pfam02661 381754001878 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 381754001879 Phage Tail Collar Domain; Region: Collar; pfam07484 381754001880 Baseplate J-like protein; Region: Baseplate_J; cl01294 381754001881 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 381754001882 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 381754001883 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 381754001884 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 381754001885 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 381754001886 catalytic residues [active] 381754001887 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 381754001888 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 381754001889 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 381754001890 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 381754001891 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 381754001892 terminase endonuclease subunit; Provisional; Region: M; PHA02537 381754001893 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 381754001894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 381754001895 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 381754001896 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 381754001897 terminase ATPase subunit; Provisional; Region: P; PHA02535 381754001898 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 381754001899 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 381754001900 Phage-related protein [Function unknown]; Region: COG4695; cl01923 381754001901 Phage portal protein; Region: Phage_portal; pfam04860 381754001902 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 381754001903 active site 381754001904 metal binding site [ion binding]; metal-binding site 381754001905 interdomain interaction site; other site 381754001906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 381754001907 non-specific DNA binding site [nucleotide binding]; other site 381754001908 salt bridge; other site 381754001909 sequence-specific DNA binding site [nucleotide binding]; other site 381754001910 integrase; Provisional; Region: int; PHA02601 381754001911 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754001912 active site 381754001913 DNA binding site [nucleotide binding] 381754001914 Int/Topo IB signature motif; other site 381754001915 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754001916 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754001917 substrate binding pocket [chemical binding]; other site 381754001918 membrane-bound complex binding site; other site 381754001919 hinge residues; other site 381754001920 PAS domain S-box; Region: sensory_box; TIGR00229 381754001921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754001922 putative active site [active] 381754001923 heme pocket [chemical binding]; other site 381754001924 PAS domain S-box; Region: sensory_box; TIGR00229 381754001925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754001926 putative active site [active] 381754001927 heme pocket [chemical binding]; other site 381754001928 PAS domain S-box; Region: sensory_box; TIGR00229 381754001929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754001930 putative active site [active] 381754001931 heme pocket [chemical binding]; other site 381754001932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754001933 PAS domain; Region: PAS_9; pfam13426 381754001934 putative active site [active] 381754001935 heme pocket [chemical binding]; other site 381754001936 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754001937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754001938 metal binding site [ion binding]; metal-binding site 381754001939 active site 381754001940 I-site; other site 381754001941 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754001942 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 381754001943 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 381754001944 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 381754001945 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 381754001946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754001947 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 381754001948 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754001949 DNA binding residues [nucleotide binding] 381754001950 DNA primase, catalytic core; Region: dnaG; TIGR01391 381754001951 CHC2 zinc finger; Region: zf-CHC2; pfam01807 381754001952 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 381754001953 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 381754001954 active site 381754001955 metal binding site [ion binding]; metal-binding site 381754001956 interdomain interaction site; other site 381754001957 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 381754001958 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 381754001959 Yqey-like protein; Region: YqeY; pfam09424 381754001960 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 381754001961 UGMP family protein; Validated; Region: PRK09604 381754001962 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 381754001963 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 381754001964 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 381754001965 homooctamer interface [polypeptide binding]; other site 381754001966 active site 381754001967 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 381754001968 catalytic center binding site [active] 381754001969 ATP binding site [chemical binding]; other site 381754001970 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 381754001971 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 381754001972 active site 381754001973 NTP binding site [chemical binding]; other site 381754001974 metal binding triad [ion binding]; metal-binding site 381754001975 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 381754001976 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754001977 Zn2+ binding site [ion binding]; other site 381754001978 Mg2+ binding site [ion binding]; other site 381754001979 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 381754001980 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 381754001981 SpoVR family protein; Provisional; Region: PRK11767 381754001982 hypothetical protein; Provisional; Region: PRK05325 381754001983 PrkA family serine protein kinase; Provisional; Region: PRK15455 381754001984 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 381754001985 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 381754001986 active site residue [active] 381754001987 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 381754001988 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 381754001989 active site 381754001990 metal binding site [ion binding]; metal-binding site 381754001991 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 381754001992 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 381754001993 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 381754001994 S-adenosylmethionine binding site [chemical binding]; other site 381754001995 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 381754001996 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 381754001997 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 381754001998 SurA N-terminal domain; Region: SurA_N; pfam09312 381754001999 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 381754002000 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 381754002001 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 381754002002 OstA-like protein; Region: OstA; cl00844 381754002003 Organic solvent tolerance protein; Region: OstA_C; pfam04453 381754002004 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 381754002005 Phosphotransferase enzyme family; Region: APH; pfam01636 381754002006 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 381754002007 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 381754002008 Substrate binding site; other site 381754002009 metal-binding site 381754002010 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 381754002011 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 381754002012 putative metal binding site [ion binding]; other site 381754002013 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 381754002014 HSP70 interaction site [polypeptide binding]; other site 381754002015 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 381754002016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754002017 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754002018 substrate binding pocket [chemical binding]; other site 381754002019 membrane-bound complex binding site; other site 381754002020 hinge residues; other site 381754002021 PAS domain S-box; Region: sensory_box; TIGR00229 381754002022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754002023 putative active site [active] 381754002024 heme pocket [chemical binding]; other site 381754002025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754002026 PAS fold; Region: PAS_3; pfam08447 381754002027 putative active site [active] 381754002028 heme pocket [chemical binding]; other site 381754002029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 381754002030 Histidine kinase; Region: HisKA_3; pfam07730 381754002031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754002032 ATP binding site [chemical binding]; other site 381754002033 Mg2+ binding site [ion binding]; other site 381754002034 G-X-G motif; other site 381754002035 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754002036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754002037 active site 381754002038 phosphorylation site [posttranslational modification] 381754002039 intermolecular recognition site; other site 381754002040 dimerization interface [polypeptide binding]; other site 381754002041 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754002042 DNA binding residues [nucleotide binding] 381754002043 dimerization interface [polypeptide binding]; other site 381754002044 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381754002045 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754002046 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 381754002047 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 381754002048 Walker A/P-loop; other site 381754002049 ATP binding site [chemical binding]; other site 381754002050 Q-loop/lid; other site 381754002051 ABC transporter signature motif; other site 381754002052 Walker B; other site 381754002053 D-loop; other site 381754002054 H-loop/switch region; other site 381754002055 TOBE domain; Region: TOBE_2; pfam08402 381754002056 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381754002057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754002058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754002059 dimer interface [polypeptide binding]; other site 381754002060 conserved gate region; other site 381754002061 putative PBP binding loops; other site 381754002062 ABC-ATPase subunit interface; other site 381754002063 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381754002064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754002065 dimer interface [polypeptide binding]; other site 381754002066 conserved gate region; other site 381754002067 putative PBP binding loops; other site 381754002068 ABC-ATPase subunit interface; other site 381754002069 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 381754002070 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 381754002071 substrate binding site [chemical binding]; other site 381754002072 hexamer interface [polypeptide binding]; other site 381754002073 metal binding site [ion binding]; metal-binding site 381754002074 phosphoglycolate phosphatase; Provisional; Region: PRK13223 381754002075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754002076 motif II; other site 381754002077 anthranilate synthase component I; Provisional; Region: PRK13565 381754002078 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 381754002079 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 381754002080 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 381754002081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754002082 non-specific DNA binding site [nucleotide binding]; other site 381754002083 Predicted transcriptional regulator [Transcription]; Region: COG2932 381754002084 salt bridge; other site 381754002085 sequence-specific DNA binding site [nucleotide binding]; other site 381754002086 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 381754002087 Catalytic site [active] 381754002088 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 381754002089 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 381754002090 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 381754002091 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 381754002092 Baseplate J-like protein; Region: Baseplate_J; cl01294 381754002093 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 381754002094 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 381754002095 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 381754002096 Phage tail tube protein FII; Region: Phage_tube; cl01390 381754002097 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 381754002098 Mu-like prophage protein [General function prediction only]; Region: COG3941 381754002099 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 381754002100 Phage Tail Protein X; Region: Phage_tail_X; cl02088 381754002101 Phage protein D [General function prediction only]; Region: COG3500 381754002102 Predicted chitinase [General function prediction only]; Region: COG3179 381754002103 catalytic residue [active] 381754002104 Phage-related minor tail protein [Function unknown]; Region: COG5281 381754002105 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 381754002106 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 381754002107 Phage-related minor tail protein [Function unknown]; Region: COG5281 381754002108 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 381754002109 Phage-related protein [Function unknown]; Region: COG4718 381754002110 Phage-related protein [Function unknown]; Region: gp18; COG4672 381754002111 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 381754002112 MPN+ (JAMM) motif; other site 381754002113 Zinc-binding site [ion binding]; other site 381754002114 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 381754002115 NlpC/P60 family; Region: NLPC_P60; pfam00877 381754002116 Phage-related protein, tail component [Function unknown]; Region: COG4723 381754002117 Phage-related protein, tail component [Function unknown]; Region: COG4733 381754002118 Putative phage tail protein; Region: Phage-tail_3; pfam13550 381754002119 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 381754002120 Interdomain contacts; other site 381754002121 Cytokine receptor motif; other site 381754002122 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 381754002123 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 381754002124 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 381754002125 glutamine binding [chemical binding]; other site 381754002126 catalytic triad [active] 381754002127 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 381754002128 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 381754002129 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 381754002130 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 381754002131 active site 381754002132 ribulose/triose binding site [chemical binding]; other site 381754002133 phosphate binding site [ion binding]; other site 381754002134 substrate (anthranilate) binding pocket [chemical binding]; other site 381754002135 product (indole) binding pocket [chemical binding]; other site 381754002136 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 381754002137 putative switch regulator; other site 381754002138 non-specific DNA interactions [nucleotide binding]; other site 381754002139 DNA binding site [nucleotide binding] 381754002140 sequence specific DNA binding site [nucleotide binding]; other site 381754002141 putative cAMP binding site [chemical binding]; other site 381754002142 OsmC-like protein; Region: OsmC; cl00767 381754002143 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 381754002144 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 381754002145 diiron binding motif [ion binding]; other site 381754002146 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 381754002147 nucleotide binding site/active site [active] 381754002148 HIT family signature motif; other site 381754002149 catalytic residue [active] 381754002150 Ycf46; Provisional; Region: ycf46; CHL00195 381754002151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754002152 Walker A motif; other site 381754002153 ATP binding site [chemical binding]; other site 381754002154 Walker B motif; other site 381754002155 arginine finger; other site 381754002156 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 381754002157 classical (c) SDRs; Region: SDR_c; cd05233 381754002158 NAD(P) binding site [chemical binding]; other site 381754002159 active site 381754002160 Double zinc ribbon; Region: DZR; pfam12773 381754002161 Predicted membrane protein [Function unknown]; Region: COG3152 381754002162 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 381754002163 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 381754002164 FMN binding site [chemical binding]; other site 381754002165 substrate binding site [chemical binding]; other site 381754002166 putative catalytic residue [active] 381754002167 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 381754002168 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 381754002169 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 381754002170 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 381754002171 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 381754002172 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 381754002173 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 381754002174 putative peptidase; Provisional; Region: PRK11649 381754002175 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 381754002176 Peptidase family M23; Region: Peptidase_M23; pfam01551 381754002177 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 381754002178 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 381754002179 active site 381754002180 HIGH motif; other site 381754002181 dimer interface [polypeptide binding]; other site 381754002182 KMSKS motif; other site 381754002183 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 381754002184 Biotin operon repressor [Transcription]; Region: BirA; COG1654 381754002185 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 381754002186 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 381754002187 pantothenate kinase; Reviewed; Region: PRK13322 381754002188 Sporulation related domain; Region: SPOR; pfam05036 381754002189 Sporulation related domain; Region: SPOR; pfam05036 381754002190 Sporulation related domain; Region: SPOR; cl10051 381754002191 elongation factor Tu; Reviewed; Region: PRK00049 381754002192 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 381754002193 G1 box; other site 381754002194 GEF interaction site [polypeptide binding]; other site 381754002195 GTP/Mg2+ binding site [chemical binding]; other site 381754002196 Switch I region; other site 381754002197 G2 box; other site 381754002198 G3 box; other site 381754002199 Switch II region; other site 381754002200 G4 box; other site 381754002201 G5 box; other site 381754002202 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 381754002203 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 381754002204 Antibiotic Binding Site [chemical binding]; other site 381754002205 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 381754002206 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 381754002207 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 381754002208 putative homodimer interface [polypeptide binding]; other site 381754002209 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 381754002210 heterodimer interface [polypeptide binding]; other site 381754002211 homodimer interface [polypeptide binding]; other site 381754002212 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 381754002213 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 381754002214 23S rRNA interface [nucleotide binding]; other site 381754002215 L7/L12 interface [polypeptide binding]; other site 381754002216 putative thiostrepton binding site; other site 381754002217 L25 interface [polypeptide binding]; other site 381754002218 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 381754002219 mRNA/rRNA interface [nucleotide binding]; other site 381754002220 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 381754002221 23S rRNA interface [nucleotide binding]; other site 381754002222 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 381754002223 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 381754002224 core dimer interface [polypeptide binding]; other site 381754002225 peripheral dimer interface [polypeptide binding]; other site 381754002226 L10 interface [polypeptide binding]; other site 381754002227 L11 interface [polypeptide binding]; other site 381754002228 putative EF-Tu interaction site [polypeptide binding]; other site 381754002229 putative EF-G interaction site [polypeptide binding]; other site 381754002230 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 381754002231 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 381754002232 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 381754002233 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 381754002234 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 381754002235 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 381754002236 RPB3 interaction site [polypeptide binding]; other site 381754002237 RPB1 interaction site [polypeptide binding]; other site 381754002238 RPB11 interaction site [polypeptide binding]; other site 381754002239 RPB10 interaction site [polypeptide binding]; other site 381754002240 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 381754002241 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 381754002242 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 381754002243 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 381754002244 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 381754002245 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 381754002246 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 381754002247 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 381754002248 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 381754002249 DNA binding site [nucleotide binding] 381754002250 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 381754002251 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 381754002252 S17 interaction site [polypeptide binding]; other site 381754002253 S8 interaction site; other site 381754002254 16S rRNA interaction site [nucleotide binding]; other site 381754002255 streptomycin interaction site [chemical binding]; other site 381754002256 23S rRNA interaction site [nucleotide binding]; other site 381754002257 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 381754002258 30S ribosomal protein S7; Validated; Region: PRK05302 381754002259 elongation factor G; Reviewed; Region: PRK00007 381754002260 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 381754002261 G1 box; other site 381754002262 putative GEF interaction site [polypeptide binding]; other site 381754002263 GTP/Mg2+ binding site [chemical binding]; other site 381754002264 Switch I region; other site 381754002265 G2 box; other site 381754002266 G3 box; other site 381754002267 Switch II region; other site 381754002268 G4 box; other site 381754002269 G5 box; other site 381754002270 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 381754002271 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 381754002272 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 381754002273 elongation factor Tu; Reviewed; Region: PRK00049 381754002274 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 381754002275 G1 box; other site 381754002276 GEF interaction site [polypeptide binding]; other site 381754002277 GTP/Mg2+ binding site [chemical binding]; other site 381754002278 Switch I region; other site 381754002279 G2 box; other site 381754002280 G3 box; other site 381754002281 Switch II region; other site 381754002282 G4 box; other site 381754002283 G5 box; other site 381754002284 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 381754002285 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 381754002286 Antibiotic Binding Site [chemical binding]; other site 381754002287 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 381754002288 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 381754002289 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 381754002290 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 381754002291 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 381754002292 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 381754002293 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 381754002294 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 381754002295 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 381754002296 protein-rRNA interface [nucleotide binding]; other site 381754002297 putative translocon binding site; other site 381754002298 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 381754002299 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 381754002300 G-X-X-G motif; other site 381754002301 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 381754002302 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 381754002303 23S rRNA interface [nucleotide binding]; other site 381754002304 5S rRNA interface [nucleotide binding]; other site 381754002305 putative antibiotic binding site [chemical binding]; other site 381754002306 L25 interface [polypeptide binding]; other site 381754002307 L27 interface [polypeptide binding]; other site 381754002308 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 381754002309 23S rRNA interface [nucleotide binding]; other site 381754002310 putative translocon interaction site; other site 381754002311 signal recognition particle (SRP54) interaction site; other site 381754002312 L23 interface [polypeptide binding]; other site 381754002313 trigger factor interaction site; other site 381754002314 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 381754002315 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 381754002316 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 381754002317 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 381754002318 RNA binding site [nucleotide binding]; other site 381754002319 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 381754002320 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 381754002321 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 381754002322 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 381754002323 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 381754002324 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 381754002325 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 381754002326 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 381754002327 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 381754002328 5S rRNA interface [nucleotide binding]; other site 381754002329 23S rRNA interface [nucleotide binding]; other site 381754002330 L5 interface [polypeptide binding]; other site 381754002331 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 381754002332 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 381754002333 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 381754002334 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 381754002335 23S rRNA binding site [nucleotide binding]; other site 381754002336 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 381754002337 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 381754002338 SecY translocase; Region: SecY; pfam00344 381754002339 Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257 381754002340 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 381754002341 30S ribosomal protein S13; Region: bact_S13; TIGR03631 381754002342 30S ribosomal protein S11; Validated; Region: PRK05309 381754002343 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 381754002344 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 381754002345 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381754002346 RNA binding surface [nucleotide binding]; other site 381754002347 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 381754002348 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 381754002349 alphaNTD homodimer interface [polypeptide binding]; other site 381754002350 alphaNTD - beta interaction site [polypeptide binding]; other site 381754002351 alphaNTD - beta' interaction site [polypeptide binding]; other site 381754002352 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 381754002353 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 381754002354 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 381754002355 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 381754002356 tetramer interface [polypeptide binding]; other site 381754002357 heme binding pocket [chemical binding]; other site 381754002358 NADPH binding site [chemical binding]; other site 381754002359 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 381754002360 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 381754002361 heme binding site [chemical binding]; other site 381754002362 ferroxidase pore; other site 381754002363 ferroxidase diiron center [ion binding]; other site 381754002364 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 381754002365 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 381754002366 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 381754002367 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 381754002368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754002369 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754002370 putative substrate translocation pore; other site 381754002371 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 381754002372 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 381754002373 dimer interface [polypeptide binding]; other site 381754002374 ssDNA binding site [nucleotide binding]; other site 381754002375 tetramer (dimer of dimers) interface [polypeptide binding]; other site 381754002376 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 381754002377 isochorismate synthases; Region: isochor_syn; TIGR00543 381754002378 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 381754002379 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 381754002380 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 381754002381 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 381754002382 acyl-activating enzyme (AAE) consensus motif; other site 381754002383 active site 381754002384 AMP binding site [chemical binding]; other site 381754002385 substrate binding site [chemical binding]; other site 381754002386 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754002387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754002388 Phosphopantetheine attachment site; Region: PP-binding; cl09936 381754002389 Condensation domain; Region: Condensation; pfam00668 381754002390 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 381754002391 Nonribosomal peptide synthase; Region: NRPS; pfam08415 381754002392 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 381754002393 acyl-activating enzyme (AAE) consensus motif; other site 381754002394 AMP binding site [chemical binding]; other site 381754002395 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754002396 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754002397 Condensation domain; Region: Condensation; pfam00668 381754002398 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 381754002399 Nonribosomal peptide synthase; Region: NRPS; pfam08415 381754002400 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 381754002401 acyl-activating enzyme (AAE) consensus motif; other site 381754002402 AMP binding site [chemical binding]; other site 381754002403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754002404 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754002405 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 381754002406 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 381754002407 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 381754002408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754002409 Walker A/P-loop; other site 381754002410 ATP binding site [chemical binding]; other site 381754002411 Q-loop/lid; other site 381754002412 ABC transporter signature motif; other site 381754002413 Walker B; other site 381754002414 D-loop; other site 381754002415 H-loop/switch region; other site 381754002416 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 381754002417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754002418 Walker A/P-loop; other site 381754002419 ATP binding site [chemical binding]; other site 381754002420 Q-loop/lid; other site 381754002421 ABC transporter signature motif; other site 381754002422 Walker B; other site 381754002423 D-loop; other site 381754002424 H-loop/switch region; other site 381754002425 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 381754002426 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754002427 N-terminal plug; other site 381754002428 ligand-binding site [chemical binding]; other site 381754002429 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 381754002430 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 381754002431 hypothetical protein; Provisional; Region: PRK07538 381754002432 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 381754002433 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 381754002434 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 381754002435 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 381754002436 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 381754002437 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 381754002438 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 381754002439 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 381754002440 Glutamine amidotransferase class-I; Region: GATase; pfam00117 381754002441 glutamine binding [chemical binding]; other site 381754002442 catalytic triad [active] 381754002443 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 381754002444 hydrophobic substrate binding pocket; other site 381754002445 Isochorismatase family; Region: Isochorismatase; pfam00857 381754002446 active site 381754002447 conserved cis-peptide bond; other site 381754002448 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 381754002449 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 381754002450 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 381754002451 O-methyltransferase; Region: Methyltransf_2; pfam00891 381754002452 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 381754002453 multidrug efflux protein; Reviewed; Region: PRK09579 381754002454 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754002455 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754002456 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754002457 Predicted membrane protein [Function unknown]; Region: COG2259 381754002458 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 381754002459 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754002460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754002461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754002462 dimerization interface [polypeptide binding]; other site 381754002463 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 381754002464 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 381754002465 FMN binding site [chemical binding]; other site 381754002466 substrate binding site [chemical binding]; other site 381754002467 putative catalytic residue [active] 381754002468 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 381754002469 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 381754002470 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754002471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381754002472 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 381754002473 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 381754002474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754002475 active site 381754002476 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 381754002477 acyl-CoA synthetase; Validated; Region: PRK08162 381754002478 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 381754002479 acyl-activating enzyme (AAE) consensus motif; other site 381754002480 putative active site [active] 381754002481 AMP binding site [chemical binding]; other site 381754002482 putative CoA binding site [chemical binding]; other site 381754002483 PAS domain S-box; Region: sensory_box; TIGR00229 381754002484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754002485 putative active site [active] 381754002486 heme pocket [chemical binding]; other site 381754002487 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754002488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754002489 dimer interface [polypeptide binding]; other site 381754002490 phosphorylation site [posttranslational modification] 381754002491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754002492 ATP binding site [chemical binding]; other site 381754002493 Mg2+ binding site [ion binding]; other site 381754002494 G-X-G motif; other site 381754002495 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 381754002496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754002497 active site 381754002498 phosphorylation site [posttranslational modification] 381754002499 intermolecular recognition site; other site 381754002500 dimerization interface [polypeptide binding]; other site 381754002501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754002502 DNA binding residues [nucleotide binding] 381754002503 dimerization interface [polypeptide binding]; other site 381754002504 putative monooxygenase; Reviewed; Region: PRK07045 381754002505 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 381754002506 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 381754002507 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 381754002508 amidase catalytic site [active] 381754002509 Zn binding residues [ion binding]; other site 381754002510 substrate binding site [chemical binding]; other site 381754002511 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 381754002512 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 381754002513 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 381754002514 conserved cys residue [active] 381754002515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754002516 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 381754002517 classical (c) SDRs; Region: SDR_c; cd05233 381754002518 NAD(P) binding site [chemical binding]; other site 381754002519 active site 381754002520 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754002521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754002522 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 381754002523 dimerization interface [polypeptide binding]; other site 381754002524 substrate binding pocket [chemical binding]; other site 381754002525 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 381754002526 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 381754002527 B3/4 domain; Region: B3_4; pfam03483 381754002528 acetolactate synthase; Reviewed; Region: PRK08322 381754002529 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 381754002530 PYR/PP interface [polypeptide binding]; other site 381754002531 dimer interface [polypeptide binding]; other site 381754002532 TPP binding site [chemical binding]; other site 381754002533 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754002534 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 381754002535 TPP-binding site [chemical binding]; other site 381754002536 dimer interface [polypeptide binding]; other site 381754002537 outer membrane porin, OprD family; Region: OprD; pfam03573 381754002538 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 381754002539 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 381754002540 putative di-iron ligands [ion binding]; other site 381754002541 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 381754002542 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 381754002543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754002544 S-adenosylmethionine binding site [chemical binding]; other site 381754002545 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 381754002546 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 381754002547 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 381754002548 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 381754002549 putative catalytic site [active] 381754002550 putative phosphate binding site [ion binding]; other site 381754002551 active site 381754002552 metal binding site A [ion binding]; metal-binding site 381754002553 DNA binding site [nucleotide binding] 381754002554 putative AP binding site [nucleotide binding]; other site 381754002555 putative metal binding site B [ion binding]; other site 381754002556 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 381754002557 intracellular protease, PfpI family; Region: PfpI; TIGR01382 381754002558 proposed catalytic triad [active] 381754002559 conserved cys residue [active] 381754002560 Predicted transcriptional regulator [Transcription]; Region: COG1959 381754002561 Transcriptional regulator; Region: Rrf2; pfam02082 381754002562 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 381754002563 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 381754002564 active site 381754002565 catalytic tetrad [active] 381754002566 Putative cyclase; Region: Cyclase; pfam04199 381754002567 amidase; Validated; Region: PRK06565 381754002568 Amidase; Region: Amidase; cl11426 381754002569 SnoaL-like domain; Region: SnoaL_3; pfam13474 381754002570 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 381754002571 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 381754002572 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 381754002573 putative NAD(P) binding site [chemical binding]; other site 381754002574 SnoaL-like domain; Region: SnoaL_3; pfam13474 381754002575 SnoaL-like domain; Region: SnoaL_2; pfam12680 381754002576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754002577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754002578 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754002579 putative effector binding pocket; other site 381754002580 dimerization interface [polypeptide binding]; other site 381754002581 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 381754002582 Bacterial SH3 domain; Region: SH3_3; pfam08239 381754002583 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 381754002584 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 381754002585 putative NAD(P) binding site [chemical binding]; other site 381754002586 catalytic Zn binding site [ion binding]; other site 381754002587 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 381754002588 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 381754002589 E3 interaction surface; other site 381754002590 lipoyl attachment site [posttranslational modification]; other site 381754002591 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 381754002592 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 381754002593 alpha subunit interface [polypeptide binding]; other site 381754002594 TPP binding site [chemical binding]; other site 381754002595 heterodimer interface [polypeptide binding]; other site 381754002596 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 381754002597 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 381754002598 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 381754002599 tetramer interface [polypeptide binding]; other site 381754002600 TPP-binding site [chemical binding]; other site 381754002601 heterodimer interface [polypeptide binding]; other site 381754002602 phosphorylation loop region [posttranslational modification] 381754002603 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 381754002604 ATP-NAD kinase; Region: NAD_kinase; pfam01513 381754002605 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 381754002606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754002607 Walker A motif; other site 381754002608 ATP binding site [chemical binding]; other site 381754002609 Walker B motif; other site 381754002610 arginine finger; other site 381754002611 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754002612 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754002613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754002614 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754002615 putative effector binding pocket; other site 381754002616 dimerization interface [polypeptide binding]; other site 381754002617 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 381754002618 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 381754002619 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 381754002620 putative active site [active] 381754002621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754002622 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 381754002623 Walker A/P-loop; other site 381754002624 ATP binding site [chemical binding]; other site 381754002625 Q-loop/lid; other site 381754002626 ABC transporter signature motif; other site 381754002627 Walker B; other site 381754002628 D-loop; other site 381754002629 H-loop/switch region; other site 381754002630 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 381754002631 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754002632 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754002633 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 381754002634 FAD binding domain; Region: FAD_binding_4; pfam01565 381754002635 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 381754002636 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 381754002637 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 381754002638 active site 381754002639 HIGH motif; other site 381754002640 dimer interface [polypeptide binding]; other site 381754002641 KMSKS motif; other site 381754002642 outer membrane porin, OprD family; Region: OprD; pfam03573 381754002643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754002644 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 381754002645 putative substrate translocation pore; other site 381754002646 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 381754002647 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 381754002648 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 381754002649 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 381754002650 Low-spin heme binding site [chemical binding]; other site 381754002651 Putative water exit pathway; other site 381754002652 Binuclear center (active site) [active] 381754002653 Putative proton exit pathway; other site 381754002654 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754002655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754002656 DNA-binding site [nucleotide binding]; DNA binding site 381754002657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754002658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754002659 homodimer interface [polypeptide binding]; other site 381754002660 catalytic residue [active] 381754002661 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 381754002662 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 381754002663 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 381754002664 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 381754002665 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 381754002666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 381754002667 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 381754002668 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 381754002669 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 381754002670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754002671 putative substrate translocation pore; other site 381754002672 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 381754002673 putative substrate binding pocket [chemical binding]; other site 381754002674 trimer interface [polypeptide binding]; other site 381754002675 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 381754002676 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 381754002677 putative active site [active] 381754002678 putative metal binding site [ion binding]; other site 381754002679 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 381754002680 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 381754002681 NAD binding site [chemical binding]; other site 381754002682 catalytic residues [active] 381754002683 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 381754002684 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 381754002685 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 381754002686 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 381754002687 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 381754002688 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754002689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754002690 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 381754002691 Phosphotransferase enzyme family; Region: APH; pfam01636 381754002692 active site 381754002693 ATP binding site [chemical binding]; other site 381754002694 antibiotic binding site [chemical binding]; other site 381754002695 Predicted periplasmic protein [Function unknown]; Region: COG3904 381754002696 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 381754002697 GAF domain; Region: GAF; pfam01590 381754002698 Phytochrome region; Region: PHY; pfam00360 381754002699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754002700 dimer interface [polypeptide binding]; other site 381754002701 phosphorylation site [posttranslational modification] 381754002702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754002703 ATP binding site [chemical binding]; other site 381754002704 Mg2+ binding site [ion binding]; other site 381754002705 G-X-G motif; other site 381754002706 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 381754002707 heme binding pocket [chemical binding]; other site 381754002708 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 381754002709 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 381754002710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754002711 Coenzyme A binding pocket [chemical binding]; other site 381754002712 putative arabinose transporter; Provisional; Region: PRK03545 381754002713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754002714 putative substrate translocation pore; other site 381754002715 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3614 381754002716 PAS domain S-box; Region: sensory_box; TIGR00229 381754002717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754002718 putative active site [active] 381754002719 heme pocket [chemical binding]; other site 381754002720 PAS domain; Region: PAS_9; pfam13426 381754002721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754002722 putative active site [active] 381754002723 heme pocket [chemical binding]; other site 381754002724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754002725 PAS fold; Region: PAS_3; pfam08447 381754002726 putative active site [active] 381754002727 heme pocket [chemical binding]; other site 381754002728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754002729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754002730 dimer interface [polypeptide binding]; other site 381754002731 phosphorylation site [posttranslational modification] 381754002732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754002733 ATP binding site [chemical binding]; other site 381754002734 Mg2+ binding site [ion binding]; other site 381754002735 G-X-G motif; other site 381754002736 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381754002737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754002738 active site 381754002739 phosphorylation site [posttranslational modification] 381754002740 intermolecular recognition site; other site 381754002741 dimerization interface [polypeptide binding]; other site 381754002742 Response regulator receiver domain; Region: Response_reg; pfam00072 381754002743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754002744 active site 381754002745 phosphorylation site [posttranslational modification] 381754002746 intermolecular recognition site; other site 381754002747 dimerization interface [polypeptide binding]; other site 381754002748 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 381754002749 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 381754002750 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754002751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754002752 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 381754002753 putative dimerization interface [polypeptide binding]; other site 381754002754 putative substrate binding pocket [chemical binding]; other site 381754002755 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 381754002756 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 381754002757 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754002758 Zn2+ binding site [ion binding]; other site 381754002759 Mg2+ binding site [ion binding]; other site 381754002760 SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; Region: SPARC_EC; cd00252 381754002761 EF-hand Ca2+ binding loops [ion binding]; other site 381754002762 FS-domain interface [polypeptide binding]; other site 381754002763 putative K+ binding site [ion binding]; other site 381754002764 Protein of unknown function (DUF692); Region: DUF692; pfam05114 381754002765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 381754002766 DoxX; Region: DoxX; pfam07681 381754002767 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 381754002768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754002769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 381754002770 dimerization interface [polypeptide binding]; other site 381754002771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 381754002772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754002773 ATP binding site [chemical binding]; other site 381754002774 Mg2+ binding site [ion binding]; other site 381754002775 G-X-G motif; other site 381754002776 osmolarity response regulator; Provisional; Region: ompR; PRK09468 381754002777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754002778 active site 381754002779 phosphorylation site [posttranslational modification] 381754002780 intermolecular recognition site; other site 381754002781 dimerization interface [polypeptide binding]; other site 381754002782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754002783 DNA binding site [nucleotide binding] 381754002784 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 381754002785 choline dehydrogenase; Validated; Region: PRK02106 381754002786 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 381754002787 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 381754002788 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 381754002789 classical (c) SDRs; Region: SDR_c; cd05233 381754002790 NAD(P) binding site [chemical binding]; other site 381754002791 active site 381754002792 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 381754002793 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 381754002794 putative NAD(P) binding site [chemical binding]; other site 381754002795 catalytic Zn binding site [ion binding]; other site 381754002796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754002797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754002798 putative substrate translocation pore; other site 381754002799 Cupin domain; Region: Cupin_2; pfam07883 381754002800 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754002801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754002802 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754002803 CoenzymeA binding site [chemical binding]; other site 381754002804 subunit interaction site [polypeptide binding]; other site 381754002805 PHB binding site; other site 381754002806 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 381754002807 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 381754002808 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 381754002809 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 381754002810 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 381754002811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754002812 NAD(P) binding site [chemical binding]; other site 381754002813 active site 381754002814 aminotransferase; Validated; Region: PRK07046 381754002815 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 381754002816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754002817 catalytic residue [active] 381754002818 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 381754002819 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 381754002820 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 381754002821 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 381754002822 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 381754002823 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 381754002824 PapC N-terminal domain; Region: PapC_N; pfam13954 381754002825 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 381754002826 PapC C-terminal domain; Region: PapC_C; pfam13953 381754002827 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 381754002828 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 381754002829 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 381754002830 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 381754002831 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 381754002832 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 381754002833 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 381754002834 Response regulator receiver domain; Region: Response_reg; pfam00072 381754002835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754002836 active site 381754002837 phosphorylation site [posttranslational modification] 381754002838 intermolecular recognition site; other site 381754002839 dimerization interface [polypeptide binding]; other site 381754002840 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754002841 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754002842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754002843 active site 381754002844 phosphorylation site [posttranslational modification] 381754002845 intermolecular recognition site; other site 381754002846 dimerization interface [polypeptide binding]; other site 381754002847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754002848 DNA binding residues [nucleotide binding] 381754002849 dimerization interface [polypeptide binding]; other site 381754002850 short chain dehydrogenase; Provisional; Region: PRK08177 381754002851 C factor cell-cell signaling protein; Provisional; Region: PRK09009 381754002852 NAD(P) binding site [chemical binding]; other site 381754002853 active site 381754002854 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754002855 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 381754002856 acyl-activating enzyme (AAE) consensus motif; other site 381754002857 AMP binding site [chemical binding]; other site 381754002858 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754002859 thioester reductase domain; Region: Thioester-redct; TIGR01746 381754002860 Male sterility protein; Region: NAD_binding_4; pfam07993 381754002861 NAD(P) binding site [chemical binding]; other site 381754002862 active site 381754002863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754002864 non-specific DNA binding site [nucleotide binding]; other site 381754002865 salt bridge; other site 381754002866 sequence-specific DNA binding site [nucleotide binding]; other site 381754002867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754002868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754002869 DNA binding residues [nucleotide binding] 381754002870 dimerization interface [polypeptide binding]; other site 381754002871 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 381754002872 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 381754002873 NAD(P) binding site [chemical binding]; other site 381754002874 catalytic residues [active] 381754002875 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 381754002876 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 381754002877 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 381754002878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754002879 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 381754002880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754002881 NAD(P) binding site [chemical binding]; other site 381754002882 active site 381754002883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754002884 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 381754002885 NAD(P) binding site [chemical binding]; other site 381754002886 active site 381754002887 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 381754002888 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 381754002889 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 381754002890 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 381754002891 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 381754002892 FtsX-like permease family; Region: FtsX; pfam02687 381754002893 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 381754002894 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 381754002895 Walker A/P-loop; other site 381754002896 ATP binding site [chemical binding]; other site 381754002897 Q-loop/lid; other site 381754002898 ABC transporter signature motif; other site 381754002899 Walker B; other site 381754002900 D-loop; other site 381754002901 H-loop/switch region; other site 381754002902 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 381754002903 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 381754002904 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 381754002905 Predicted methyltransferase [General function prediction only]; Region: COG3897 381754002906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 381754002907 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 381754002908 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 381754002909 ATP cone domain; Region: ATP-cone; pfam03477 381754002910 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 381754002911 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 381754002912 catalytic motif [active] 381754002913 Zn binding site [ion binding]; other site 381754002914 RibD C-terminal domain; Region: RibD_C; cl17279 381754002915 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 381754002916 Lumazine binding domain; Region: Lum_binding; pfam00677 381754002917 Lumazine binding domain; Region: Lum_binding; pfam00677 381754002918 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 381754002919 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 381754002920 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 381754002921 dimerization interface [polypeptide binding]; other site 381754002922 active site 381754002923 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 381754002924 homopentamer interface [polypeptide binding]; other site 381754002925 active site 381754002926 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 381754002927 thiamine monophosphate kinase; Provisional; Region: PRK05731 381754002928 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 381754002929 ATP binding site [chemical binding]; other site 381754002930 dimerization interface [polypeptide binding]; other site 381754002931 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 381754002932 tetramer interfaces [polypeptide binding]; other site 381754002933 binuclear metal-binding site [ion binding]; other site 381754002934 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754002935 Predicted aspartyl protease [General function prediction only]; Region: COG3577 381754002936 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 381754002937 catalytic motif [active] 381754002938 Catalytic residue [active] 381754002939 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 381754002940 dimerization interface [polypeptide binding]; other site 381754002941 active site 381754002942 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 381754002943 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 381754002944 cobalamin binding residues [chemical binding]; other site 381754002945 putative BtuC binding residues; other site 381754002946 dimer interface [polypeptide binding]; other site 381754002947 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 381754002948 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 381754002949 TPP-binding site; other site 381754002950 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 381754002951 PYR/PP interface [polypeptide binding]; other site 381754002952 dimer interface [polypeptide binding]; other site 381754002953 TPP binding site [chemical binding]; other site 381754002954 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 381754002955 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 381754002956 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 381754002957 substrate binding pocket [chemical binding]; other site 381754002958 chain length determination region; other site 381754002959 substrate-Mg2+ binding site; other site 381754002960 catalytic residues [active] 381754002961 aspartate-rich region 1; other site 381754002962 active site lid residues [active] 381754002963 aspartate-rich region 2; other site 381754002964 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 381754002965 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 381754002966 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 381754002967 metal binding site [ion binding]; metal-binding site 381754002968 substrate binding pocket [chemical binding]; other site 381754002969 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754002970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754002971 DNA-binding site [nucleotide binding]; DNA binding site 381754002972 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754002973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754002974 homodimer interface [polypeptide binding]; other site 381754002975 catalytic residue [active] 381754002976 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 381754002977 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 381754002978 DsbD alpha interface [polypeptide binding]; other site 381754002979 catalytic residues [active] 381754002980 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 381754002981 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 381754002982 catalytic residues [active] 381754002983 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 381754002984 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 381754002985 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 381754002986 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 381754002987 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 381754002988 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381754002989 Walker A/P-loop; other site 381754002990 ATP binding site [chemical binding]; other site 381754002991 Q-loop/lid; other site 381754002992 ABC transporter signature motif; other site 381754002993 Walker B; other site 381754002994 D-loop; other site 381754002995 H-loop/switch region; other site 381754002996 CHASE2 domain; Region: CHASE2; pfam05226 381754002997 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 381754002998 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754002999 PAS domain; Region: PAS_8; pfam13188 381754003000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754003001 dimer interface [polypeptide binding]; other site 381754003002 phosphorylation site [posttranslational modification] 381754003003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754003004 ATP binding site [chemical binding]; other site 381754003005 Mg2+ binding site [ion binding]; other site 381754003006 G-X-G motif; other site 381754003007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 381754003008 FecR protein; Region: FecR; pfam04773 381754003009 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 381754003010 amphipathic channel; other site 381754003011 Asn-Pro-Ala signature motifs; other site 381754003012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754003013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754003014 active site 381754003015 phosphorylation site [posttranslational modification] 381754003016 intermolecular recognition site; other site 381754003017 dimerization interface [polypeptide binding]; other site 381754003018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754003019 DNA binding site [nucleotide binding] 381754003020 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 381754003021 dimer interface [polypeptide binding]; other site 381754003022 substrate binding site [chemical binding]; other site 381754003023 metal binding sites [ion binding]; metal-binding site 381754003024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228 381754003025 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 381754003026 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 381754003027 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 381754003028 substrate binding site [chemical binding]; other site 381754003029 activation loop (A-loop); other site 381754003030 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754003031 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754003032 substrate binding pocket [chemical binding]; other site 381754003033 membrane-bound complex binding site; other site 381754003034 hinge residues; other site 381754003035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754003036 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 381754003037 Coenzyme A binding pocket [chemical binding]; other site 381754003038 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 381754003039 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 381754003040 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 381754003041 ethanolamine permease; Region: 2A0305; TIGR00908 381754003042 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 381754003043 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 381754003044 NAD(P) binding site [chemical binding]; other site 381754003045 catalytic residues [active] 381754003046 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 381754003047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754003048 putative active site [active] 381754003049 heme pocket [chemical binding]; other site 381754003050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754003051 Walker A motif; other site 381754003052 ATP binding site [chemical binding]; other site 381754003053 Walker B motif; other site 381754003054 arginine finger; other site 381754003055 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754003056 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 381754003057 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 381754003058 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381754003059 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381754003060 aromatic acid decarboxylase; Validated; Region: PRK05920 381754003061 Flavoprotein; Region: Flavoprotein; pfam02441 381754003062 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5645 381754003063 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 381754003064 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 381754003065 NAD binding site [chemical binding]; other site 381754003066 active site 381754003067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 381754003068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 381754003069 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698 381754003070 Peptidase C13 family; Region: Peptidase_C13; pfam01650 381754003071 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 381754003072 putative active site [active] 381754003073 putative catalytic site [active] 381754003074 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 381754003075 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 381754003076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 381754003077 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 381754003078 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 381754003079 active site 381754003080 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 381754003081 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 381754003082 active site 381754003083 DNA binding site [nucleotide binding] 381754003084 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 381754003085 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 381754003086 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754003087 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 381754003088 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 381754003089 putative catalytic cysteine [active] 381754003090 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 381754003091 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 381754003092 active site 381754003093 (T/H)XGH motif; other site 381754003094 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 381754003095 Uncharacterized conserved protein [Function unknown]; Region: COG1576 381754003096 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 381754003097 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 381754003098 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 381754003099 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 381754003100 Transglycosylase SLT domain; Region: SLT_2; pfam13406 381754003101 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754003102 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754003103 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 381754003104 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 381754003105 Sporulation related domain; Region: SPOR; pfam05036 381754003106 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 381754003107 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 381754003108 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 381754003109 hypothetical protein; Provisional; Region: PRK00341 381754003110 lipoate-protein ligase B; Provisional; Region: PRK14342 381754003111 lipoyl synthase; Provisional; Region: PRK05481 381754003112 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754003113 FeS/SAM binding site; other site 381754003114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754003115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754003116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754003117 dimerization interface [polypeptide binding]; other site 381754003118 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754003119 Transglycosylase SLT domain; Region: SLT_2; pfam13406 381754003120 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754003121 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754003122 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 381754003123 Domain of unknown function; Region: DUF331; cl01149 381754003124 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 381754003125 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 381754003126 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 381754003127 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 381754003128 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 381754003129 HIGH motif; other site 381754003130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 381754003131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 381754003132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 381754003133 active site 381754003134 KMSKS motif; other site 381754003135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 381754003136 tRNA binding surface [nucleotide binding]; other site 381754003137 Uncharacterized conserved protein [Function unknown]; Region: COG1434 381754003138 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 381754003139 putative active site [active] 381754003140 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 381754003141 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 381754003142 putative active site [active] 381754003143 catalytic triad [active] 381754003144 putative dimer interface [polypeptide binding]; other site 381754003145 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 381754003146 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 381754003147 Transporter associated domain; Region: CorC_HlyC; smart01091 381754003148 metal-binding heat shock protein; Provisional; Region: PRK00016 381754003149 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 381754003150 PhoH-like protein; Region: PhoH; pfam02562 381754003151 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 381754003152 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 381754003153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754003154 FeS/SAM binding site; other site 381754003155 TRAM domain; Region: TRAM; pfam01938 381754003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4517 381754003157 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 381754003158 Sel1-like repeats; Region: SEL1; smart00671 381754003159 Sel1-like repeats; Region: SEL1; smart00671 381754003160 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 381754003161 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754003162 inhibitor-cofactor binding pocket; inhibition site 381754003163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754003164 catalytic residue [active] 381754003165 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 381754003166 thiamine phosphate binding site [chemical binding]; other site 381754003167 active site 381754003168 pyrophosphate binding site [ion binding]; other site 381754003169 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 381754003170 dimer interface [polypeptide binding]; other site 381754003171 substrate binding site [chemical binding]; other site 381754003172 ATP binding site [chemical binding]; other site 381754003173 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 381754003174 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 381754003175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754003176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754003177 dimer interface [polypeptide binding]; other site 381754003178 phosphorylation site [posttranslational modification] 381754003179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754003180 ATP binding site [chemical binding]; other site 381754003181 Mg2+ binding site [ion binding]; other site 381754003182 G-X-G motif; other site 381754003183 Response regulator receiver domain; Region: Response_reg; pfam00072 381754003184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754003185 active site 381754003186 phosphorylation site [posttranslational modification] 381754003187 intermolecular recognition site; other site 381754003188 dimerization interface [polypeptide binding]; other site 381754003189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754003190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754003191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754003192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754003193 active site 381754003194 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754003195 CoenzymeA binding site [chemical binding]; other site 381754003196 subunit interaction site [polypeptide binding]; other site 381754003197 PHB binding site; other site 381754003198 AMP nucleosidase; Provisional; Region: PRK08292 381754003199 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 381754003200 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 381754003201 SEC-C motif; Region: SEC-C; pfam02810 381754003202 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 381754003203 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 381754003204 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 381754003205 pseudouridine synthase; Region: TIGR00093 381754003206 active site 381754003207 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 381754003208 heme-binding site [chemical binding]; other site 381754003209 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 381754003210 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754003211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754003212 putative DNA binding site [nucleotide binding]; other site 381754003213 putative Zn2+ binding site [ion binding]; other site 381754003214 AsnC family; Region: AsnC_trans_reg; pfam01037 381754003215 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 381754003216 Cation efflux family; Region: Cation_efflux; cl00316 381754003217 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 381754003218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754003219 ATP binding site [chemical binding]; other site 381754003220 putative Mg++ binding site [ion binding]; other site 381754003221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754003222 nucleotide binding region [chemical binding]; other site 381754003223 ATP-binding site [chemical binding]; other site 381754003224 Helicase associated domain (HA2); Region: HA2; pfam04408 381754003225 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 381754003226 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754003227 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 381754003228 putative catalytic site [active] 381754003229 putative metal binding site [ion binding]; other site 381754003230 putative phosphate binding site [ion binding]; other site 381754003231 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 381754003232 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 381754003233 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 381754003234 active site 381754003235 dimer interface [polypeptide binding]; other site 381754003236 non-prolyl cis peptide bond; other site 381754003237 insertion regions; other site 381754003238 Isochorismatase family; Region: Isochorismatase; pfam00857 381754003239 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 381754003240 catalytic triad [active] 381754003241 conserved cis-peptide bond; other site 381754003242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 381754003243 Uncharacterized conserved protein [Function unknown]; Region: COG1432 381754003244 LabA_like proteins; Region: LabA; cd10911 381754003245 putative metal binding site [ion binding]; other site 381754003246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 381754003247 ATP binding site [chemical binding]; other site 381754003248 putative Mg++ binding site [ion binding]; other site 381754003249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754003250 nucleotide binding region [chemical binding]; other site 381754003251 ATP-binding site [chemical binding]; other site 381754003252 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 381754003253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754003254 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 381754003255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754003256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754003257 active site 381754003258 phosphorylation site [posttranslational modification] 381754003259 intermolecular recognition site; other site 381754003260 dimerization interface [polypeptide binding]; other site 381754003261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754003262 DNA binding residues [nucleotide binding] 381754003263 dimerization interface [polypeptide binding]; other site 381754003264 Response regulator receiver domain; Region: Response_reg; pfam00072 381754003265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754003266 active site 381754003267 phosphorylation site [posttranslational modification] 381754003268 intermolecular recognition site; other site 381754003269 dimerization interface [polypeptide binding]; other site 381754003270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754003271 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 381754003272 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754003273 substrate binding pocket [chemical binding]; other site 381754003274 membrane-bound complex binding site; other site 381754003275 hinge residues; other site 381754003276 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754003277 substrate binding pocket [chemical binding]; other site 381754003278 membrane-bound complex binding site; other site 381754003279 hinge residues; other site 381754003280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754003281 putative active site [active] 381754003282 heme pocket [chemical binding]; other site 381754003283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754003284 dimer interface [polypeptide binding]; other site 381754003285 phosphorylation site [posttranslational modification] 381754003286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754003287 ATP binding site [chemical binding]; other site 381754003288 Mg2+ binding site [ion binding]; other site 381754003289 G-X-G motif; other site 381754003290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754003291 active site 381754003292 phosphorylation site [posttranslational modification] 381754003293 intermolecular recognition site; other site 381754003294 dimerization interface [polypeptide binding]; other site 381754003295 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754003296 putative binding surface; other site 381754003297 active site 381754003298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 381754003299 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 381754003300 NADPH bind site [chemical binding]; other site 381754003301 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 381754003302 putative FMN binding site [chemical binding]; other site 381754003303 NADPH bind site [chemical binding]; other site 381754003304 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 381754003305 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 381754003306 active site 381754003307 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 381754003308 catalytic triad [active] 381754003309 dimer interface [polypeptide binding]; other site 381754003310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754003311 active site 381754003312 motif I; other site 381754003313 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 381754003314 motif II; other site 381754003315 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 381754003316 IHF dimer interface [polypeptide binding]; other site 381754003317 IHF - DNA interface [nucleotide binding]; other site 381754003318 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 381754003319 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754003320 substrate binding pocket [chemical binding]; other site 381754003321 membrane-bound complex binding site; other site 381754003322 hinge residues; other site 381754003323 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 381754003324 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 381754003325 Walker A/P-loop; other site 381754003326 ATP binding site [chemical binding]; other site 381754003327 Q-loop/lid; other site 381754003328 ABC transporter signature motif; other site 381754003329 Walker B; other site 381754003330 D-loop; other site 381754003331 H-loop/switch region; other site 381754003332 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 381754003333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754003334 dimer interface [polypeptide binding]; other site 381754003335 conserved gate region; other site 381754003336 putative PBP binding loops; other site 381754003337 ABC-ATPase subunit interface; other site 381754003338 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 381754003339 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 381754003340 Predicted membrane protein [Function unknown]; Region: COG1297 381754003341 BCCT family transporter; Region: BCCT; cl00569 381754003342 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 381754003343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754003344 Walker A motif; other site 381754003345 ATP binding site [chemical binding]; other site 381754003346 Walker B motif; other site 381754003347 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 381754003348 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 381754003349 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 381754003350 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 381754003351 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 381754003352 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 381754003353 Cupin domain; Region: Cupin_2; cl17218 381754003354 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754003355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754003356 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754003357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754003358 putative substrate translocation pore; other site 381754003359 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 381754003360 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754003361 dimer interface [polypeptide binding]; other site 381754003362 active site 381754003363 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 381754003364 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 381754003365 dimer interface [polypeptide binding]; other site 381754003366 acyl-activating enzyme (AAE) consensus motif; other site 381754003367 putative active site [active] 381754003368 AMP binding site [chemical binding]; other site 381754003369 putative CoA binding site [chemical binding]; other site 381754003370 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 381754003371 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 381754003372 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 381754003373 AAA ATPase domain; Region: AAA_16; pfam13191 381754003374 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754003375 DNA binding residues [nucleotide binding] 381754003376 dimerization interface [polypeptide binding]; other site 381754003377 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 381754003378 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754003379 metal-binding site [ion binding] 381754003380 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 381754003381 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754003382 metal-binding site [ion binding] 381754003383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381754003384 Soluble P-type ATPase [General function prediction only]; Region: COG4087 381754003385 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 381754003386 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 381754003387 putative active site [active] 381754003388 PhoH-like protein; Region: PhoH; pfam02562 381754003389 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 381754003390 trimer interface [polypeptide binding]; other site 381754003391 dimer interface [polypeptide binding]; other site 381754003392 putative active site [active] 381754003393 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 381754003394 MoaE interaction surface [polypeptide binding]; other site 381754003395 MoeB interaction surface [polypeptide binding]; other site 381754003396 thiocarboxylated glycine; other site 381754003397 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 381754003398 MoaE homodimer interface [polypeptide binding]; other site 381754003399 MoaD interaction [polypeptide binding]; other site 381754003400 active site residues [active] 381754003401 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 381754003402 MPT binding site; other site 381754003403 trimer interface [polypeptide binding]; other site 381754003404 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 381754003405 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 381754003406 dimer interface [polypeptide binding]; other site 381754003407 putative functional site; other site 381754003408 putative MPT binding site; other site 381754003409 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 381754003410 Peptidase family U32; Region: Peptidase_U32; pfam01136 381754003411 putative protease; Provisional; Region: PRK15447 381754003412 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 381754003413 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 381754003414 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 381754003415 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 381754003416 putative active site [active] 381754003417 putative metal binding site [ion binding]; other site 381754003418 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 381754003419 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 381754003420 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 381754003421 generic binding surface I; other site 381754003422 generic binding surface II; other site 381754003423 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 381754003424 putative active site [active] 381754003425 putative catalytic site [active] 381754003426 putative Mg binding site IVb [ion binding]; other site 381754003427 putative phosphate binding site [ion binding]; other site 381754003428 putative DNA binding site [nucleotide binding]; other site 381754003429 putative Mg binding site IVa [ion binding]; other site 381754003430 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 381754003431 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 381754003432 G1 box; other site 381754003433 putative GEF interaction site [polypeptide binding]; other site 381754003434 GTP/Mg2+ binding site [chemical binding]; other site 381754003435 Switch I region; other site 381754003436 G2 box; other site 381754003437 G3 box; other site 381754003438 Switch II region; other site 381754003439 G4 box; other site 381754003440 G5 box; other site 381754003441 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 381754003442 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 381754003443 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 381754003444 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754003445 N-terminal plug; other site 381754003446 ligand-binding site [chemical binding]; other site 381754003447 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754003448 FecR protein; Region: FecR; pfam04773 381754003449 RNA polymerase sigma factor; Provisional; Region: PRK12528 381754003450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754003451 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754003452 DNA binding residues [nucleotide binding] 381754003453 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 381754003454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754003455 EamA-like transporter family; Region: EamA; pfam00892 381754003456 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 381754003457 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 381754003458 dimerization interface [polypeptide binding]; other site 381754003459 ligand binding site [chemical binding]; other site 381754003460 NADP binding site [chemical binding]; other site 381754003461 catalytic site [active] 381754003462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754003463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754003464 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754003465 putative effector binding pocket; other site 381754003466 dimerization interface [polypeptide binding]; other site 381754003467 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 381754003468 Fusaric acid resistance protein family; Region: FUSC; pfam04632 381754003469 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 381754003470 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 381754003471 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 381754003472 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754003473 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754003474 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 381754003475 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 381754003476 Walker A/P-loop; other site 381754003477 ATP binding site [chemical binding]; other site 381754003478 Q-loop/lid; other site 381754003479 ABC transporter signature motif; other site 381754003480 Walker B; other site 381754003481 D-loop; other site 381754003482 H-loop/switch region; other site 381754003483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 381754003484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754003485 dimer interface [polypeptide binding]; other site 381754003486 conserved gate region; other site 381754003487 ABC-ATPase subunit interface; other site 381754003488 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 381754003489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754003490 ABC-ATPase subunit interface; other site 381754003491 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 381754003492 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 381754003493 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 381754003494 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 381754003495 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 381754003496 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 381754003497 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 381754003498 short chain dehydrogenase; Provisional; Region: PRK05693 381754003499 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 381754003500 NADP binding site [chemical binding]; other site 381754003501 active site 381754003502 steroid binding site; other site 381754003503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754003504 S-adenosylmethionine binding site [chemical binding]; other site 381754003505 Uncharacterized conserved protein [Function unknown]; Region: COG4273 381754003506 transcriptional regulator NarL; Provisional; Region: PRK10651 381754003507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754003508 active site 381754003509 phosphorylation site [posttranslational modification] 381754003510 intermolecular recognition site; other site 381754003511 dimerization interface [polypeptide binding]; other site 381754003512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754003513 DNA binding residues [nucleotide binding] 381754003514 dimerization interface [polypeptide binding]; other site 381754003515 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 381754003516 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 381754003517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754003518 dimerization interface [polypeptide binding]; other site 381754003519 Histidine kinase; Region: HisKA_3; pfam07730 381754003520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754003521 ATP binding site [chemical binding]; other site 381754003522 Mg2+ binding site [ion binding]; other site 381754003523 G-X-G motif; other site 381754003524 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 381754003525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754003526 putative substrate translocation pore; other site 381754003527 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 381754003528 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 381754003529 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 381754003530 [4Fe-4S] binding site [ion binding]; other site 381754003531 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 381754003532 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 381754003533 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 381754003534 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 381754003535 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 381754003536 molybdopterin cofactor binding site; other site 381754003537 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 381754003538 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 381754003539 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 381754003540 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 381754003541 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 381754003542 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 381754003543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754003544 FeS/SAM binding site; other site 381754003545 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 381754003546 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 381754003547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754003548 substrate binding pocket [chemical binding]; other site 381754003549 membrane-bound complex binding site; other site 381754003550 hinge residues; other site 381754003551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 381754003552 YheO-like PAS domain; Region: PAS_6; pfam08348 381754003553 HTH domain; Region: HTH_22; pfam13309 381754003554 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754003555 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381754003556 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 381754003557 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 381754003558 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 381754003559 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 381754003560 ATP binding site [chemical binding]; other site 381754003561 Mg++ binding site [ion binding]; other site 381754003562 motif III; other site 381754003563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754003564 nucleotide binding region [chemical binding]; other site 381754003565 ATP-binding site [chemical binding]; other site 381754003566 AMP-binding domain protein; Validated; Region: PRK07529 381754003567 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754003568 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 381754003569 acyl-activating enzyme (AAE) consensus motif; other site 381754003570 putative AMP binding site [chemical binding]; other site 381754003571 putative active site [active] 381754003572 putative CoA binding site [chemical binding]; other site 381754003573 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 381754003574 putative hydrolase; Provisional; Region: PRK11460 381754003575 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 381754003576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 381754003577 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 381754003578 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 381754003579 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 381754003580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 381754003581 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 381754003582 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 381754003583 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 381754003584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754003585 substrate binding pocket [chemical binding]; other site 381754003586 membrane-bound complex binding site; other site 381754003587 hinge residues; other site 381754003588 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 381754003589 SnoaL-like domain; Region: SnoaL_2; pfam12680 381754003590 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 381754003591 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754003592 putative C-terminal domain interface [polypeptide binding]; other site 381754003593 putative GSH binding site [chemical binding]; other site 381754003594 putative dimer interface [polypeptide binding]; other site 381754003595 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 381754003596 putative N-terminal domain interface [polypeptide binding]; other site 381754003597 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 381754003598 GIY-YIG motif/motif A; other site 381754003599 putative active site [active] 381754003600 putative metal binding site [ion binding]; other site 381754003601 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 381754003602 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 381754003603 trimer interface [polypeptide binding]; other site 381754003604 active site 381754003605 substrate binding site [chemical binding]; other site 381754003606 CoA binding site [chemical binding]; other site 381754003607 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754003608 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 381754003609 C-terminal domain interface [polypeptide binding]; other site 381754003610 GSH binding site (G-site) [chemical binding]; other site 381754003611 dimer interface [polypeptide binding]; other site 381754003612 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 381754003613 substrate binding pocket (H-site) [chemical binding]; other site 381754003614 N-terminal domain interface [polypeptide binding]; other site 381754003615 CCC1-related family of proteins; Region: CCC1_like; cl00278 381754003616 Nucleoid-associated protein [General function prediction only]; Region: COG3081 381754003617 nucleoid-associated protein NdpA; Validated; Region: PRK00378 381754003618 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 381754003619 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 381754003620 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 381754003621 hydrophobic ligand binding site; other site 381754003622 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 381754003623 Isochorismatase family; Region: Isochorismatase; pfam00857 381754003624 catalytic triad [active] 381754003625 dimer interface [polypeptide binding]; other site 381754003626 conserved cis-peptide bond; other site 381754003627 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754003628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754003629 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 381754003630 dimerization interface [polypeptide binding]; other site 381754003631 substrate binding pocket [chemical binding]; other site 381754003632 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754003633 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 381754003634 C-terminal domain interface [polypeptide binding]; other site 381754003635 GSH binding site (G-site) [chemical binding]; other site 381754003636 dimer interface [polypeptide binding]; other site 381754003637 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 381754003638 dimer interface [polypeptide binding]; other site 381754003639 N-terminal domain interface [polypeptide binding]; other site 381754003640 putative substrate binding pocket (H-site) [chemical binding]; other site 381754003641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754003642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754003643 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 381754003644 putative dimerization interface [polypeptide binding]; other site 381754003645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 381754003646 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 381754003647 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 381754003648 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 381754003649 Citrate transporter; Region: CitMHS; pfam03600 381754003650 outer membrane porin, OprD family; Region: OprD; pfam03573 381754003651 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 381754003652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754003653 S-adenosylmethionine binding site [chemical binding]; other site 381754003654 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 381754003655 transmembrane helices; other site 381754003656 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 381754003657 TrkA-C domain; Region: TrkA_C; pfam02080 381754003658 TrkA-C domain; Region: TrkA_C; pfam02080 381754003659 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 381754003660 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 381754003661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754003662 Walker A/P-loop; other site 381754003663 ATP binding site [chemical binding]; other site 381754003664 Q-loop/lid; other site 381754003665 ABC transporter signature motif; other site 381754003666 Walker B; other site 381754003667 D-loop; other site 381754003668 H-loop/switch region; other site 381754003669 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381754003670 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 381754003671 TM-ABC transporter signature motif; other site 381754003672 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 381754003673 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 381754003674 zinc binding site [ion binding]; other site 381754003675 putative ligand binding site [chemical binding]; other site 381754003676 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 381754003677 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 381754003678 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 381754003679 HIGH motif; other site 381754003680 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 381754003681 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 381754003682 active site 381754003683 KMSKS motif; other site 381754003684 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 381754003685 tRNA binding surface [nucleotide binding]; other site 381754003686 anticodon binding site; other site 381754003687 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 381754003688 DNA polymerase III subunit chi; Validated; Region: PRK05728 381754003689 multifunctional aminopeptidase A; Provisional; Region: PRK00913 381754003690 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 381754003691 interface (dimer of trimers) [polypeptide binding]; other site 381754003692 Substrate-binding/catalytic site; other site 381754003693 Zn-binding sites [ion binding]; other site 381754003694 Predicted permeases [General function prediction only]; Region: COG0795 381754003695 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 381754003696 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 381754003697 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 381754003698 RDD family; Region: RDD; pfam06271 381754003699 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 381754003700 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754003701 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 381754003702 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 381754003703 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 381754003704 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 381754003705 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 381754003706 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 381754003707 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 381754003708 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 381754003709 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 381754003710 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 381754003711 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 381754003712 Protein export membrane protein; Region: SecD_SecF; pfam02355 381754003713 hypothetical protein; Provisional; Region: PRK11280 381754003714 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 381754003715 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 381754003716 active site 381754003717 dimerization interface [polypeptide binding]; other site 381754003718 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 381754003719 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 381754003720 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 381754003721 serine O-acetyltransferase; Region: cysE; TIGR01172 381754003722 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 381754003723 trimer interface [polypeptide binding]; other site 381754003724 active site 381754003725 substrate binding site [chemical binding]; other site 381754003726 CoA binding site [chemical binding]; other site 381754003727 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 381754003728 Rrf2 family protein; Region: rrf2_super; TIGR00738 381754003729 cysteine desulfurase; Provisional; Region: PRK14012 381754003730 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 381754003731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754003732 catalytic residue [active] 381754003733 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 381754003734 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 381754003735 trimerization site [polypeptide binding]; other site 381754003736 active site 381754003737 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 381754003738 co-chaperone HscB; Provisional; Region: hscB; PRK00294 381754003739 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 381754003740 HSP70 interaction site [polypeptide binding]; other site 381754003741 chaperone protein HscA; Provisional; Region: hscA; PRK05183 381754003742 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 381754003743 nucleotide binding site [chemical binding]; other site 381754003744 putative NEF/HSP70 interaction site [polypeptide binding]; other site 381754003745 SBD interface [polypeptide binding]; other site 381754003746 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 381754003747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754003748 catalytic loop [active] 381754003749 iron binding site [ion binding]; other site 381754003750 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 381754003751 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 381754003752 active site 381754003753 multimer interface [polypeptide binding]; other site 381754003754 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 381754003755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754003756 FeS/SAM binding site; other site 381754003757 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 381754003758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754003759 binding surface 381754003760 TPR motif; other site 381754003761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754003762 binding surface 381754003763 TPR motif; other site 381754003764 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 381754003765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754003766 non-specific DNA binding site [nucleotide binding]; other site 381754003767 salt bridge; other site 381754003768 sequence-specific DNA binding site [nucleotide binding]; other site 381754003769 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 381754003770 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 381754003771 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 381754003772 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 381754003773 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 381754003774 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 381754003775 dimer interface [polypeptide binding]; other site 381754003776 motif 1; other site 381754003777 active site 381754003778 motif 2; other site 381754003779 motif 3; other site 381754003780 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 381754003781 anticodon binding site; other site 381754003782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 381754003783 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 381754003784 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 381754003785 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 381754003786 Trp docking motif [polypeptide binding]; other site 381754003787 active site 381754003788 GTP-binding protein Der; Reviewed; Region: PRK00093 381754003789 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 381754003790 G1 box; other site 381754003791 GTP/Mg2+ binding site [chemical binding]; other site 381754003792 Switch I region; other site 381754003793 G2 box; other site 381754003794 Switch II region; other site 381754003795 G3 box; other site 381754003796 G4 box; other site 381754003797 G5 box; other site 381754003798 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 381754003799 G1 box; other site 381754003800 GTP/Mg2+ binding site [chemical binding]; other site 381754003801 Switch I region; other site 381754003802 G2 box; other site 381754003803 G3 box; other site 381754003804 Switch II region; other site 381754003805 G4 box; other site 381754003806 G5 box; other site 381754003807 methionine aminotransferase; Validated; Region: PRK09082 381754003808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754003809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754003810 homodimer interface [polypeptide binding]; other site 381754003811 catalytic residue [active] 381754003812 C-N hydrolase family amidase; Provisional; Region: PRK10438 381754003813 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 381754003814 putative active site [active] 381754003815 catalytic triad [active] 381754003816 dimer interface [polypeptide binding]; other site 381754003817 multimer interface [polypeptide binding]; other site 381754003818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 381754003819 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 381754003820 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 381754003821 active site 381754003822 catalytic tetrad [active] 381754003823 2-isopropylmalate synthase; Validated; Region: PRK03739 381754003824 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 381754003825 active site 381754003826 catalytic residues [active] 381754003827 metal binding site [ion binding]; metal-binding site 381754003828 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 381754003829 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 381754003830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754003831 N-terminal plug; other site 381754003832 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 381754003833 ligand-binding site [chemical binding]; other site 381754003834 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 381754003835 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 381754003836 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 381754003837 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 381754003838 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 381754003839 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 381754003840 Peptidase family M23; Region: Peptidase_M23; pfam01551 381754003841 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 381754003842 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 381754003843 AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061 381754003844 Isochorismatase family; Region: Isochorismatase; pfam00857 381754003845 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 381754003846 catalytic triad [active] 381754003847 conserved cis-peptide bond; other site 381754003848 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 381754003849 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 381754003850 conserved cys residue [active] 381754003851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754003852 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 381754003853 DctM-like transporters; Region: DctM; pfam06808 381754003854 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 381754003855 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 381754003856 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 381754003857 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 381754003858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754003859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754003860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754003861 dimerization interface [polypeptide binding]; other site 381754003862 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 381754003863 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 381754003864 generic binding surface II; other site 381754003865 generic binding surface I; other site 381754003866 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 381754003867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754003868 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 381754003869 dimerization interface [polypeptide binding]; other site 381754003870 substrate binding pocket [chemical binding]; other site 381754003871 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 381754003872 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 381754003873 active site 381754003874 Zn binding site [ion binding]; other site 381754003875 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 381754003876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754003877 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754003878 DNA binding residues [nucleotide binding] 381754003879 dimerization interface [polypeptide binding]; other site 381754003880 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 381754003881 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 381754003882 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 381754003883 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 381754003884 active site 381754003885 GMP synthase; Reviewed; Region: guaA; PRK00074 381754003886 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 381754003887 AMP/PPi binding site [chemical binding]; other site 381754003888 candidate oxyanion hole; other site 381754003889 catalytic triad [active] 381754003890 potential glutamine specificity residues [chemical binding]; other site 381754003891 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 381754003892 ATP Binding subdomain [chemical binding]; other site 381754003893 Dimerization subdomain; other site 381754003894 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 381754003895 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 381754003896 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 381754003897 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 381754003898 nucleoside/Zn binding site; other site 381754003899 dimer interface [polypeptide binding]; other site 381754003900 catalytic motif [active] 381754003901 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 381754003902 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 381754003903 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 381754003904 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 381754003905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754003906 substrate binding pocket [chemical binding]; other site 381754003907 membrane-bound complex binding site; other site 381754003908 hinge residues; other site 381754003909 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754003910 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754003911 catalytic residue [active] 381754003912 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 381754003913 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 381754003914 dimerization interface [polypeptide binding]; other site 381754003915 ATP binding site [chemical binding]; other site 381754003916 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 381754003917 dimerization interface [polypeptide binding]; other site 381754003918 ATP binding site [chemical binding]; other site 381754003919 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 381754003920 putative active site [active] 381754003921 catalytic triad [active] 381754003922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 381754003923 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 381754003924 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 381754003925 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 381754003926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 381754003927 active site turn [active] 381754003928 phosphorylation site [posttranslational modification] 381754003929 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 381754003930 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 381754003931 active site turn [active] 381754003932 phosphorylation site [posttranslational modification] 381754003933 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 381754003934 HPr interaction site; other site 381754003935 glycerol kinase (GK) interaction site [polypeptide binding]; other site 381754003936 active site 381754003937 phosphorylation site [posttranslational modification] 381754003938 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 381754003939 dimerization domain swap beta strand [polypeptide binding]; other site 381754003940 regulatory protein interface [polypeptide binding]; other site 381754003941 active site 381754003942 regulatory phosphorylation site [posttranslational modification]; other site 381754003943 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 381754003944 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 381754003945 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 381754003946 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 381754003947 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 381754003948 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 381754003949 dimer interface [polypeptide binding]; other site 381754003950 active site 381754003951 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 381754003952 dimer interface [polypeptide binding]; other site 381754003953 active site 381754003954 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 381754003955 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 381754003956 active site 381754003957 dimer interface [polypeptide binding]; other site 381754003958 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 381754003959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754003960 DNA-binding site [nucleotide binding]; DNA binding site 381754003961 UTRA domain; Region: UTRA; pfam07702 381754003962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 381754003963 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 381754003964 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 381754003965 nudix motif; other site 381754003966 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 381754003967 putative active site [active] 381754003968 putative CoA binding site [chemical binding]; other site 381754003969 nudix motif; other site 381754003970 metal binding site [ion binding]; metal-binding site 381754003971 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 381754003972 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 381754003973 trimer interface [polypeptide binding]; other site 381754003974 putative metal binding site [ion binding]; other site 381754003975 Predicted Fe-S protein [General function prediction only]; Region: COG3313 381754003976 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 381754003977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754003978 ATP-grasp domain; Region: ATP-grasp; pfam02222 381754003979 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 381754003980 active site 381754003981 catalytic triad [active] 381754003982 oxyanion hole [active] 381754003983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754003984 metabolite-proton symporter; Region: 2A0106; TIGR00883 381754003985 putative substrate translocation pore; other site 381754003986 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 381754003987 Domain of unknown function DUF21; Region: DUF21; pfam01595 381754003988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 381754003989 Transporter associated domain; Region: CorC_HlyC; smart01091 381754003990 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 381754003991 signal recognition particle protein; Provisional; Region: PRK10867 381754003992 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 381754003993 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 381754003994 P loop; other site 381754003995 GTP binding site [chemical binding]; other site 381754003996 Signal peptide binding domain; Region: SRP_SPB; pfam02978 381754003997 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 381754003998 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 381754003999 RimM N-terminal domain; Region: RimM; pfam01782 381754004000 PRC-barrel domain; Region: PRC; pfam05239 381754004001 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 381754004002 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 381754004003 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 381754004004 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 381754004005 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 381754004006 TrkA-N domain; Region: TrkA_N; pfam02254 381754004007 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 381754004008 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 381754004009 active site 381754004010 Int/Topo IB signature motif; other site 381754004011 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 381754004012 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 381754004013 dimerization domain [polypeptide binding]; other site 381754004014 dimer interface [polypeptide binding]; other site 381754004015 catalytic residues [active] 381754004016 homoserine dehydrogenase; Provisional; Region: PRK06349 381754004017 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 381754004018 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 381754004019 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 381754004020 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 381754004021 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 381754004022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754004023 catalytic residue [active] 381754004024 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 381754004025 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 381754004026 CoA-transferase family III; Region: CoA_transf_3; pfam02515 381754004027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 381754004028 PspA/IM30 family; Region: PspA_IM30; pfam04012 381754004029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 381754004030 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 381754004031 ATPase involved in DNA repair; Region: DUF3686; pfam12458 381754004032 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 381754004033 linker region; other site 381754004034 AAA domain; Region: AAA_22; pfam13401 381754004035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754004036 Walker A motif; other site 381754004037 ATP binding site [chemical binding]; other site 381754004038 Walker B motif; other site 381754004039 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 381754004040 PLD-like domain; Region: PLDc_2; pfam13091 381754004041 putative active site [active] 381754004042 catalytic site [active] 381754004043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 381754004044 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 381754004045 DHH family; Region: DHH; pfam01368 381754004046 DHHA1 domain; Region: DHHA1; pfam02272 381754004047 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 381754004048 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 381754004049 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 381754004050 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 381754004051 active site 381754004052 Zn binding site [ion binding]; other site 381754004053 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 381754004054 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 381754004055 active site 381754004056 FMN binding site [chemical binding]; other site 381754004057 substrate binding site [chemical binding]; other site 381754004058 homotetramer interface [polypeptide binding]; other site 381754004059 catalytic residue [active] 381754004060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754004061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754004062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754004063 putative substrate translocation pore; other site 381754004064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754004065 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 381754004066 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 381754004067 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 381754004068 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 381754004069 GspL periplasmic domain; Region: GspL_C; cl14909 381754004070 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 381754004071 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 381754004072 type II secretion system protein J; Region: gspJ; TIGR01711 381754004073 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 381754004074 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 381754004075 type II secretion system protein I; Region: gspI; TIGR01707 381754004076 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 381754004077 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 381754004078 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 381754004079 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 381754004080 type II secretion system protein F; Region: GspF; TIGR02120 381754004081 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754004082 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754004083 type II secretion system protein E; Region: type_II_gspE; TIGR02533 381754004084 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 381754004085 Walker A motif; other site 381754004086 ATP binding site [chemical binding]; other site 381754004087 Walker B motif; other site 381754004088 type II secretion system protein D; Region: type_II_gspD; TIGR02517 381754004089 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754004090 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754004091 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754004092 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381754004093 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 381754004094 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 381754004095 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 381754004096 Chitin binding domain; Region: Chitin_bind_3; pfam03067 381754004097 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 381754004098 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754004099 substrate binding pocket [chemical binding]; other site 381754004100 membrane-bound complex binding site; other site 381754004101 hinge residues; other site 381754004102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754004103 substrate binding pocket [chemical binding]; other site 381754004104 membrane-bound complex binding site; other site 381754004105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754004106 putative active site [active] 381754004107 heme pocket [chemical binding]; other site 381754004108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754004109 dimer interface [polypeptide binding]; other site 381754004110 phosphorylation site [posttranslational modification] 381754004111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754004112 ATP binding site [chemical binding]; other site 381754004113 Mg2+ binding site [ion binding]; other site 381754004114 G-X-G motif; other site 381754004115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754004116 active site 381754004117 phosphorylation site [posttranslational modification] 381754004118 intermolecular recognition site; other site 381754004119 dimerization interface [polypeptide binding]; other site 381754004120 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 381754004121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754004122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754004123 active site 381754004124 phosphorylation site [posttranslational modification] 381754004125 intermolecular recognition site; other site 381754004126 dimerization interface [polypeptide binding]; other site 381754004127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754004128 DNA binding residues [nucleotide binding] 381754004129 dimerization interface [polypeptide binding]; other site 381754004130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381754004131 Protein of unknown function (DUF533); Region: DUF533; pfam04391 381754004132 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 381754004133 putative metal binding site [ion binding]; other site 381754004134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754004135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754004136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754004137 dimerization interface [polypeptide binding]; other site 381754004138 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 381754004139 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 381754004140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754004141 putative substrate translocation pore; other site 381754004142 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 381754004143 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 381754004144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754004145 dimerization interface [polypeptide binding]; other site 381754004146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754004147 dimer interface [polypeptide binding]; other site 381754004148 putative CheW interface [polypeptide binding]; other site 381754004149 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 381754004150 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 381754004151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754004152 S-adenosylmethionine binding site [chemical binding]; other site 381754004153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 381754004154 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 381754004155 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754004156 putative binding surface; other site 381754004157 active site 381754004158 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 381754004159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754004160 ATP binding site [chemical binding]; other site 381754004161 Mg2+ binding site [ion binding]; other site 381754004162 G-X-G motif; other site 381754004163 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 381754004164 Response regulator receiver domain; Region: Response_reg; pfam00072 381754004165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754004166 active site 381754004167 phosphorylation site [posttranslational modification] 381754004168 intermolecular recognition site; other site 381754004169 dimerization interface [polypeptide binding]; other site 381754004170 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 381754004171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754004172 active site 381754004173 phosphorylation site [posttranslational modification] 381754004174 intermolecular recognition site; other site 381754004175 CheB methylesterase; Region: CheB_methylest; pfam01339 381754004176 Response regulator receiver domain; Region: Response_reg; pfam00072 381754004177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754004178 active site 381754004179 phosphorylation site [posttranslational modification] 381754004180 intermolecular recognition site; other site 381754004181 dimerization interface [polypeptide binding]; other site 381754004182 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754004183 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754004184 metal binding site [ion binding]; metal-binding site 381754004185 active site 381754004186 I-site; other site 381754004187 peptide chain release factor 2; Validated; Region: prfB; PRK00578 381754004188 This domain is found in peptide chain release factors; Region: PCRF; smart00937 381754004189 RF-1 domain; Region: RF-1; pfam00472 381754004190 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 381754004191 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 381754004192 dimer interface [polypeptide binding]; other site 381754004193 putative anticodon binding site; other site 381754004194 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 381754004195 motif 1; other site 381754004196 active site 381754004197 motif 2; other site 381754004198 motif 3; other site 381754004199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 381754004200 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 381754004201 Uncharacterized conserved protein [Function unknown]; Region: COG2013 381754004202 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754004203 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754004204 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381754004205 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 381754004206 putative ADP-ribose binding site [chemical binding]; other site 381754004207 putative active site [active] 381754004208 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754004209 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754004210 ligand binding site [chemical binding]; other site 381754004211 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 381754004212 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 381754004213 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 381754004214 metal-binding site [ion binding] 381754004215 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381754004216 Soluble P-type ATPase [General function prediction only]; Region: COG4087 381754004217 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 381754004218 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 381754004219 DNA binding residues [nucleotide binding] 381754004220 dimer interface [polypeptide binding]; other site 381754004221 putative metal binding site [ion binding]; other site 381754004222 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 381754004223 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 381754004224 adenylate kinase; Reviewed; Region: adk; PRK00279 381754004225 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 381754004226 AMP-binding site [chemical binding]; other site 381754004227 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 381754004228 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 381754004229 Glycoprotease family; Region: Peptidase_M22; pfam00814 381754004230 Protein of unknown function DUF72; Region: DUF72; cl00777 381754004231 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 381754004232 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 381754004233 tetramer interface [polypeptide binding]; other site 381754004234 active site 381754004235 Mg2+/Mn2+ binding site [ion binding]; other site 381754004236 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 381754004237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754004238 S-adenosylmethionine binding site [chemical binding]; other site 381754004239 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 381754004240 Cytochrome P450; Region: p450; cl12078 381754004241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754004242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754004243 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 381754004244 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754004245 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754004246 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754004247 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 381754004248 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 381754004249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 381754004250 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 381754004251 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 381754004252 putative acyl-acceptor binding pocket; other site 381754004253 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 381754004254 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381754004255 Walker A/P-loop; other site 381754004256 ATP binding site [chemical binding]; other site 381754004257 Q-loop/lid; other site 381754004258 ABC transporter signature motif; other site 381754004259 Walker B; other site 381754004260 D-loop; other site 381754004261 H-loop/switch region; other site 381754004262 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 381754004263 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 381754004264 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 381754004265 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 381754004266 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 381754004267 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 381754004268 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754004269 catalytic residue [active] 381754004270 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 381754004271 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 381754004272 putative trimer interface [polypeptide binding]; other site 381754004273 putative CoA binding site [chemical binding]; other site 381754004274 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754004275 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 381754004276 ArsC family; Region: ArsC; pfam03960 381754004277 putative catalytic residues [active] 381754004278 Flagellin N-methylase; Region: FliB; cl00497 381754004279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 381754004280 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 381754004281 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 381754004282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754004283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754004284 homodimer interface [polypeptide binding]; other site 381754004285 catalytic residue [active] 381754004286 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 381754004287 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 381754004288 metal binding triad; other site 381754004289 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 381754004290 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754004291 Zn2+ binding site [ion binding]; other site 381754004292 Mg2+ binding site [ion binding]; other site 381754004293 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 381754004294 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 381754004295 methionine aminopeptidase; Provisional; Region: PRK08671 381754004296 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 381754004297 active site 381754004298 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 381754004299 rRNA interaction site [nucleotide binding]; other site 381754004300 S8 interaction site; other site 381754004301 putative laminin-1 binding site; other site 381754004302 elongation factor Ts; Provisional; Region: tsf; PRK09377 381754004303 UBA/TS-N domain; Region: UBA; pfam00627 381754004304 Elongation factor TS; Region: EF_TS; pfam00889 381754004305 Elongation factor TS; Region: EF_TS; pfam00889 381754004306 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 381754004307 putative nucleotide binding site [chemical binding]; other site 381754004308 uridine monophosphate binding site [chemical binding]; other site 381754004309 homohexameric interface [polypeptide binding]; other site 381754004310 ribosome recycling factor; Reviewed; Region: frr; PRK00083 381754004311 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 381754004312 hinge region; other site 381754004313 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 381754004314 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 381754004315 catalytic residue [active] 381754004316 putative FPP diphosphate binding site; other site 381754004317 putative FPP binding hydrophobic cleft; other site 381754004318 dimer interface [polypeptide binding]; other site 381754004319 putative IPP diphosphate binding site; other site 381754004320 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 381754004321 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 381754004322 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 381754004323 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 381754004324 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 381754004325 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 381754004326 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 381754004327 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 381754004328 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 381754004329 zinc metallopeptidase RseP; Provisional; Region: PRK10779 381754004330 active site 381754004331 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 381754004332 protein binding site [polypeptide binding]; other site 381754004333 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 381754004334 protein binding site [polypeptide binding]; other site 381754004335 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 381754004336 putative substrate binding region [chemical binding]; other site 381754004337 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 381754004338 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381754004339 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381754004340 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381754004341 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381754004342 Surface antigen; Region: Bac_surface_Ag; pfam01103 381754004343 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 381754004344 periplasmic chaperone; Provisional; Region: PRK10780 381754004345 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 381754004346 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 381754004347 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 381754004348 trimer interface [polypeptide binding]; other site 381754004349 active site 381754004350 UDP-GlcNAc binding site [chemical binding]; other site 381754004351 lipid binding site [chemical binding]; lipid-binding site 381754004352 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 381754004353 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 381754004354 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 381754004355 active site 381754004356 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 381754004357 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 381754004358 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 381754004359 RNA/DNA hybrid binding site [nucleotide binding]; other site 381754004360 active site 381754004361 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 381754004362 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 381754004363 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 381754004364 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 381754004365 putative active site [active] 381754004366 putative PHP Thumb interface [polypeptide binding]; other site 381754004367 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 381754004368 generic binding surface II; other site 381754004369 generic binding surface I; other site 381754004370 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 381754004371 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 381754004372 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 381754004373 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 381754004374 Ligand Binding Site [chemical binding]; other site 381754004375 TilS substrate binding domain; Region: TilS; pfam09179 381754004376 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 381754004377 CTP synthetase; Validated; Region: pyrG; PRK05380 381754004378 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 381754004379 Catalytic site [active] 381754004380 active site 381754004381 UTP binding site [chemical binding]; other site 381754004382 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 381754004383 active site 381754004384 putative oxyanion hole; other site 381754004385 catalytic triad [active] 381754004386 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 381754004387 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 381754004388 enolase; Provisional; Region: eno; PRK00077 381754004389 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 381754004390 dimer interface [polypeptide binding]; other site 381754004391 metal binding site [ion binding]; metal-binding site 381754004392 substrate binding pocket [chemical binding]; other site 381754004393 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 381754004394 Septum formation initiator; Region: DivIC; cl17659 381754004395 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 381754004396 substrate binding site; other site 381754004397 dimer interface; other site 381754004398 hypothetical protein; Provisional; Region: PRK11018 381754004399 CPxP motif; other site 381754004400 putative inner membrane protein; Provisional; Region: PRK11099 381754004401 Sulphur transport; Region: Sulf_transp; pfam04143 381754004402 LysR family transcriptional regulator; Provisional; Region: PRK14997 381754004403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754004404 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 381754004405 putative effector binding pocket; other site 381754004406 putative dimerization interface [polypeptide binding]; other site 381754004407 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 381754004408 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 381754004409 substrate binding site [chemical binding]; other site 381754004410 catalytic Zn binding site [ion binding]; other site 381754004411 NAD binding site [chemical binding]; other site 381754004412 structural Zn binding site [ion binding]; other site 381754004413 dimer interface [polypeptide binding]; other site 381754004414 S-formylglutathione hydrolase; Region: PLN02442 381754004415 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 381754004416 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 381754004417 homotrimer interaction site [polypeptide binding]; other site 381754004418 zinc binding site [ion binding]; other site 381754004419 CDP-binding sites; other site 381754004420 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 381754004421 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 381754004422 Permutation of conserved domain; other site 381754004423 active site 381754004424 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 381754004425 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 381754004426 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 381754004427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754004428 S-adenosylmethionine binding site [chemical binding]; other site 381754004429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754004430 Peptidase family M23; Region: Peptidase_M23; pfam01551 381754004431 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 381754004432 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 381754004433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754004434 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 381754004435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754004436 DNA binding residues [nucleotide binding] 381754004437 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 381754004438 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 381754004439 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 381754004440 MutS domain I; Region: MutS_I; pfam01624 381754004441 MutS domain II; Region: MutS_II; pfam05188 381754004442 MutS domain III; Region: MutS_III; pfam05192 381754004443 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 381754004444 Walker A/P-loop; other site 381754004445 ATP binding site [chemical binding]; other site 381754004446 Q-loop/lid; other site 381754004447 ABC transporter signature motif; other site 381754004448 Walker B; other site 381754004449 D-loop; other site 381754004450 H-loop/switch region; other site 381754004451 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 381754004452 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 381754004453 recombinase A; Provisional; Region: recA; PRK09354 381754004454 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 381754004455 hexamer interface [polypeptide binding]; other site 381754004456 Walker A motif; other site 381754004457 ATP binding site [chemical binding]; other site 381754004458 Walker B motif; other site 381754004459 recombination regulator RecX; Reviewed; Region: recX; PRK00117 381754004460 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 381754004461 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 381754004462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381754004463 Beta-Casp domain; Region: Beta-Casp; smart01027 381754004464 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 381754004465 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 381754004466 XFP N-terminal domain; Region: XFP_N; pfam09364 381754004467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 381754004468 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 381754004469 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381754004470 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754004471 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381754004472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754004473 dimer interface [polypeptide binding]; other site 381754004474 conserved gate region; other site 381754004475 putative PBP binding loops; other site 381754004476 ABC-ATPase subunit interface; other site 381754004477 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381754004478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754004479 dimer interface [polypeptide binding]; other site 381754004480 conserved gate region; other site 381754004481 putative PBP binding loops; other site 381754004482 ABC-ATPase subunit interface; other site 381754004483 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 381754004484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754004485 Walker A/P-loop; other site 381754004486 ATP binding site [chemical binding]; other site 381754004487 Q-loop/lid; other site 381754004488 ABC transporter signature motif; other site 381754004489 Walker B; other site 381754004490 D-loop; other site 381754004491 H-loop/switch region; other site 381754004492 TOBE domain; Region: TOBE_2; pfam08402 381754004493 Uncharacterized conserved protein [Function unknown]; Region: COG3148 381754004494 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 381754004495 EamA-like transporter family; Region: EamA; pfam00892 381754004496 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754004497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754004498 active site 381754004499 phosphorylation site [posttranslational modification] 381754004500 intermolecular recognition site; other site 381754004501 dimerization interface [polypeptide binding]; other site 381754004502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754004503 DNA binding residues [nucleotide binding] 381754004504 dimerization interface [polypeptide binding]; other site 381754004505 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 381754004506 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 381754004507 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 381754004508 active site 381754004509 FMN binding site [chemical binding]; other site 381754004510 substrate binding site [chemical binding]; other site 381754004511 3Fe-4S cluster binding site [ion binding]; other site 381754004512 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 381754004513 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 381754004514 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754004515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754004516 DNA binding residues [nucleotide binding] 381754004517 dimerization interface [polypeptide binding]; other site 381754004518 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 381754004519 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 381754004520 putative active site [active] 381754004521 catalytic triad [active] 381754004522 putative dimer interface [polypeptide binding]; other site 381754004523 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 381754004524 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 381754004525 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 381754004526 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 381754004527 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 381754004528 DNA binding site [nucleotide binding] 381754004529 active site 381754004530 metabolite-proton symporter; Region: 2A0106; TIGR00883 381754004531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754004532 putative substrate translocation pore; other site 381754004533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754004534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754004535 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 381754004536 putative dimerization interface [polypeptide binding]; other site 381754004537 putative substrate binding pocket [chemical binding]; other site 381754004538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754004539 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754004540 active site 381754004541 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 381754004542 CoA-transferase family III; Region: CoA_transf_3; pfam02515 381754004543 enoyl-CoA hydratase; Provisional; Region: PRK08138 381754004544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754004545 substrate binding site [chemical binding]; other site 381754004546 oxyanion hole (OAH) forming residues; other site 381754004547 trimer interface [polypeptide binding]; other site 381754004548 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 381754004549 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381754004550 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754004551 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754004552 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 381754004553 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754004554 dimer interface [polypeptide binding]; other site 381754004555 active site 381754004556 outer membrane porin, OprD family; Region: OprD; pfam03573 381754004557 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 381754004558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754004559 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 381754004560 putative dimerization interface [polypeptide binding]; other site 381754004561 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 381754004562 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 381754004563 THF binding site; other site 381754004564 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 381754004565 substrate binding site [chemical binding]; other site 381754004566 THF binding site; other site 381754004567 zinc-binding site [ion binding]; other site 381754004568 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754004569 GlpM protein; Region: GlpM; pfam06942 381754004570 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 381754004571 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 381754004572 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 381754004573 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 381754004574 glycerol kinase; Provisional; Region: glpK; PRK00047 381754004575 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 381754004576 N- and C-terminal domain interface [polypeptide binding]; other site 381754004577 active site 381754004578 MgATP binding site [chemical binding]; other site 381754004579 catalytic site [active] 381754004580 metal binding site [ion binding]; metal-binding site 381754004581 glycerol binding site [chemical binding]; other site 381754004582 homotetramer interface [polypeptide binding]; other site 381754004583 homodimer interface [polypeptide binding]; other site 381754004584 FBP binding site [chemical binding]; other site 381754004585 protein IIAGlc interface [polypeptide binding]; other site 381754004586 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 381754004587 amphipathic channel; other site 381754004588 Asn-Pro-Ala signature motifs; other site 381754004589 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 381754004590 putative deacylase active site [active] 381754004591 glycerol kinase; Region: glycerol_kin; TIGR01311 381754004592 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 381754004593 N- and C-terminal domain interface [polypeptide binding]; other site 381754004594 active site 381754004595 MgATP binding site [chemical binding]; other site 381754004596 catalytic site [active] 381754004597 metal binding site [ion binding]; metal-binding site 381754004598 glycerol binding site [chemical binding]; other site 381754004599 homotetramer interface [polypeptide binding]; other site 381754004600 homodimer interface [polypeptide binding]; other site 381754004601 FBP binding site [chemical binding]; other site 381754004602 protein IIAGlc interface [polypeptide binding]; other site 381754004603 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 381754004604 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 381754004605 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754004606 metal-binding site [ion binding] 381754004607 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 381754004608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754004609 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 381754004610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754004611 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 381754004612 putative substrate translocation pore; other site 381754004613 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754004614 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754004615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754004616 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 381754004617 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 381754004618 tetrameric interface [polypeptide binding]; other site 381754004619 NAD binding site [chemical binding]; other site 381754004620 catalytic residues [active] 381754004621 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 381754004622 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 381754004623 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 381754004624 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 381754004625 acyl-activating enzyme (AAE) consensus motif; other site 381754004626 putative AMP binding site [chemical binding]; other site 381754004627 putative active site [active] 381754004628 putative CoA binding site [chemical binding]; other site 381754004629 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 381754004630 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 381754004631 putative NAD(P) binding site [chemical binding]; other site 381754004632 dimer interface [polypeptide binding]; other site 381754004633 Uncharacterized conserved protein [Function unknown]; Region: COG1359 381754004634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754004635 transcriptional activator TtdR; Provisional; Region: PRK09801 381754004636 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754004637 putative effector binding pocket; other site 381754004638 dimerization interface [polypeptide binding]; other site 381754004639 Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140 381754004640 putative RNAase interaction site [polypeptide binding]; other site 381754004641 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 381754004642 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 381754004643 active site 381754004644 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 381754004645 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381754004646 DNA binding site [nucleotide binding] 381754004647 domain linker motif; other site 381754004648 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 381754004649 dimerization interface [polypeptide binding]; other site 381754004650 ligand binding site [chemical binding]; other site 381754004651 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 381754004652 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 381754004653 active site 381754004654 phosphorylation site [posttranslational modification] 381754004655 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 381754004656 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 381754004657 dimerization domain swap beta strand [polypeptide binding]; other site 381754004658 regulatory protein interface [polypeptide binding]; other site 381754004659 active site 381754004660 regulatory phosphorylation site [posttranslational modification]; other site 381754004661 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 381754004662 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 381754004663 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 381754004664 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 381754004665 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 381754004666 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 381754004667 putative substrate binding site [chemical binding]; other site 381754004668 putative ATP binding site [chemical binding]; other site 381754004669 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 381754004670 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 381754004671 active site 381754004672 P-loop; other site 381754004673 phosphorylation site [posttranslational modification] 381754004674 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 381754004675 active site 381754004676 P-loop; other site 381754004677 phosphorylation site [posttranslational modification] 381754004678 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 381754004679 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 381754004680 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381754004681 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 381754004682 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 381754004683 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 381754004684 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 381754004685 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 381754004686 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 381754004687 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 381754004688 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 381754004689 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 381754004690 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 381754004691 active site 381754004692 substrate binding site [chemical binding]; other site 381754004693 cosubstrate binding site; other site 381754004694 catalytic site [active] 381754004695 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 381754004696 active site 381754004697 hexamer interface [polypeptide binding]; other site 381754004698 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 381754004699 NAD binding site [chemical binding]; other site 381754004700 substrate binding site [chemical binding]; other site 381754004701 active site 381754004702 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 381754004703 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 381754004704 Ligand binding site; other site 381754004705 Putative Catalytic site; other site 381754004706 DXD motif; other site 381754004707 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 381754004708 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 381754004709 inhibitor-cofactor binding pocket; inhibition site 381754004710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754004711 catalytic residue [active] 381754004712 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 381754004713 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 381754004714 Substrate binding site; other site 381754004715 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 381754004716 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 381754004717 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 381754004718 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 381754004719 active site 381754004720 Right handed beta helix region; Region: Beta_helix; pfam13229 381754004721 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 381754004722 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 381754004723 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 381754004724 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 381754004725 PilZ domain; Region: PilZ; pfam07238 381754004726 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754004727 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 381754004728 active site 381754004729 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 381754004730 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 381754004731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754004732 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 381754004733 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 381754004734 hypothetical protein; Validated; Region: PRK02101 381754004735 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 381754004736 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 381754004737 Walker A/P-loop; other site 381754004738 ATP binding site [chemical binding]; other site 381754004739 Q-loop/lid; other site 381754004740 ABC transporter signature motif; other site 381754004741 Walker B; other site 381754004742 D-loop; other site 381754004743 H-loop/switch region; other site 381754004744 TOBE domain; Region: TOBE_2; pfam08402 381754004745 ornithine carbamoyltransferase; Provisional; Region: PRK00779 381754004746 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 381754004747 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 381754004748 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 381754004749 catalytic triad [active] 381754004750 putative active site [active] 381754004751 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 381754004752 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 381754004753 Autotransporter beta-domain; Region: Autotransporter; smart00869 381754004754 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 381754004755 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 381754004756 putative [Fe4-S4] binding site [ion binding]; other site 381754004757 putative molybdopterin cofactor binding site [chemical binding]; other site 381754004758 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 381754004759 putative molybdopterin cofactor binding site; other site 381754004760 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 381754004761 putative GSH binding site [chemical binding]; other site 381754004762 catalytic residues [active] 381754004763 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 381754004764 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 381754004765 heme binding site [chemical binding]; other site 381754004766 ferroxidase pore; other site 381754004767 ferroxidase diiron center [ion binding]; other site 381754004768 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 381754004769 peroxidase; Provisional; Region: PRK15000 381754004770 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 381754004771 dimer interface [polypeptide binding]; other site 381754004772 decamer (pentamer of dimers) interface [polypeptide binding]; other site 381754004773 catalytic triad [active] 381754004774 peroxidatic and resolving cysteines [active] 381754004775 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 381754004776 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 381754004777 dimer interface [polypeptide binding]; other site 381754004778 catalytic site [active] 381754004779 putative active site [active] 381754004780 putative substrate binding site [chemical binding]; other site 381754004781 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 381754004782 active site 381754004783 substrate binding pocket [chemical binding]; other site 381754004784 dimer interface [polypeptide binding]; other site 381754004785 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754004786 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754004787 ligand binding site [chemical binding]; other site 381754004788 argininosuccinate synthase; Provisional; Region: PRK13820 381754004789 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 381754004790 ANP binding site [chemical binding]; other site 381754004791 Substrate Binding Site II [chemical binding]; other site 381754004792 Substrate Binding Site I [chemical binding]; other site 381754004793 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754004794 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 381754004795 dimer interface [polypeptide binding]; other site 381754004796 active site 381754004797 metal binding site [ion binding]; metal-binding site 381754004798 glutathione binding site [chemical binding]; other site 381754004799 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754004800 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754004801 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754004802 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 381754004803 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 381754004804 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754004805 metal-binding site [ion binding] 381754004806 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 381754004807 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 381754004808 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 381754004809 tetramer interface [polypeptide binding]; other site 381754004810 active site 381754004811 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 381754004812 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 381754004813 tetramer interface [polypeptide binding]; other site 381754004814 active site 381754004815 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754004816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754004817 S-adenosylmethionine binding site [chemical binding]; other site 381754004818 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 381754004819 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 381754004820 minor groove reading motif; other site 381754004821 helix-hairpin-helix signature motif; other site 381754004822 substrate binding pocket [chemical binding]; other site 381754004823 active site 381754004824 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 381754004825 electron transport complex RsxE subunit; Provisional; Region: PRK12405 381754004826 FMN-binding domain; Region: FMN_bind; cl01081 381754004827 electron transport complex, RnfABCDGE type, D subunit; Region: rnfD; TIGR01946 381754004828 electron transport complex protein RnfC; Provisional; Region: PRK05035 381754004829 SLBB domain; Region: SLBB; pfam10531 381754004830 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 381754004831 Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389 381754004832 electron transport complex protein RnfB; Provisional; Region: PRK05113 381754004833 Putative Fe-S cluster; Region: FeS; pfam04060 381754004834 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 381754004835 electron transport complex protein RsxA; Provisional; Region: PRK05151 381754004836 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 381754004837 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 381754004838 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 381754004839 active site 381754004840 HIGH motif; other site 381754004841 KMSKS motif; other site 381754004842 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 381754004843 tRNA binding surface [nucleotide binding]; other site 381754004844 anticodon binding site; other site 381754004845 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 381754004846 putative tRNA-binding site [nucleotide binding]; other site 381754004847 dimer interface [polypeptide binding]; other site 381754004848 antiporter inner membrane protein; Provisional; Region: PRK11670 381754004849 Domain of unknown function DUF59; Region: DUF59; pfam01883 381754004850 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 381754004851 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 381754004852 trimer interface [polypeptide binding]; other site 381754004853 active site 381754004854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754004855 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 381754004856 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 381754004857 homodimer interface [polypeptide binding]; other site 381754004858 active site 381754004859 TDP-binding site; other site 381754004860 acceptor substrate-binding pocket; other site 381754004861 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 381754004862 Autoinducer binding domain; Region: Autoind_bind; pfam03472 381754004863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754004864 DNA binding residues [nucleotide binding] 381754004865 dimerization interface [polypeptide binding]; other site 381754004866 Autoinducer synthetase; Region: Autoind_synth; cl17404 381754004867 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 381754004868 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754004869 substrate binding pocket [chemical binding]; other site 381754004870 membrane-bound complex binding site; other site 381754004871 hinge residues; other site 381754004872 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 381754004873 Predicted permeases [General function prediction only]; Region: RarD; COG2962 381754004874 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 381754004875 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 381754004876 NlpC/P60 family; Region: NLPC_P60; pfam00877 381754004877 malate dehydrogenase; Provisional; Region: PRK13529 381754004878 Malic enzyme, N-terminal domain; Region: malic; pfam00390 381754004879 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 381754004880 NAD(P) binding site [chemical binding]; other site 381754004881 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 381754004882 nudix motif; other site 381754004883 RibD C-terminal domain; Region: RibD_C; cl17279 381754004884 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 381754004885 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 381754004886 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381754004887 benzoate transport; Region: 2A0115; TIGR00895 381754004888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754004889 putative substrate translocation pore; other site 381754004890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754004891 helicase 45; Provisional; Region: PTZ00424 381754004892 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 381754004893 ATP binding site [chemical binding]; other site 381754004894 Mg++ binding site [ion binding]; other site 381754004895 motif III; other site 381754004896 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754004897 nucleotide binding region [chemical binding]; other site 381754004898 ATP-binding site [chemical binding]; other site 381754004899 Transmembrane secretion effector; Region: MFS_3; pfam05977 381754004900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754004901 putative substrate translocation pore; other site 381754004902 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 381754004903 hypothetical protein; Provisional; Region: PRK00304 381754004904 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 381754004905 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 381754004906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754004907 dimer interface [polypeptide binding]; other site 381754004908 phosphorylation site [posttranslational modification] 381754004909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754004910 ATP binding site [chemical binding]; other site 381754004911 Mg2+ binding site [ion binding]; other site 381754004912 G-X-G motif; other site 381754004913 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381754004914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754004915 active site 381754004916 phosphorylation site [posttranslational modification] 381754004917 intermolecular recognition site; other site 381754004918 dimerization interface [polypeptide binding]; other site 381754004919 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 381754004920 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 381754004921 putative oligomer interface [polypeptide binding]; other site 381754004922 putative active site [active] 381754004923 metal binding site [ion binding]; metal-binding site 381754004924 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 381754004925 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 381754004926 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754004927 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 381754004928 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 381754004929 active site 381754004930 dimer interface [polypeptide binding]; other site 381754004931 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 381754004932 Ligand Binding Site [chemical binding]; other site 381754004933 Molecular Tunnel; other site 381754004934 Transcriptional regulators [Transcription]; Region: MarR; COG1846 381754004935 MarR family; Region: MarR_2; cl17246 381754004936 Predicted permeases [General function prediction only]; Region: COG0730 381754004937 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 381754004938 Uncharacterized conserved protein [Function unknown]; Region: COG4121 381754004939 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 381754004940 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 381754004941 Polyphosphate kinase 2 (PPK2); Region: PPK2; pfam03976 381754004942 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 381754004943 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754004944 dimer interface [polypeptide binding]; other site 381754004945 active site 381754004946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 381754004947 malate:quinone oxidoreductase; Validated; Region: PRK05257 381754004948 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 381754004949 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 381754004950 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 381754004951 dimer interface [polypeptide binding]; other site 381754004952 decamer (pentamer of dimers) interface [polypeptide binding]; other site 381754004953 catalytic triad [active] 381754004954 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 381754004955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754004956 substrate binding pocket [chemical binding]; other site 381754004957 membrane-bound complex binding site; other site 381754004958 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 381754004959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754004960 dimer interface [polypeptide binding]; other site 381754004961 conserved gate region; other site 381754004962 putative PBP binding loops; other site 381754004963 ABC-ATPase subunit interface; other site 381754004964 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 381754004965 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 381754004966 Walker A/P-loop; other site 381754004967 ATP binding site [chemical binding]; other site 381754004968 Q-loop/lid; other site 381754004969 ABC transporter signature motif; other site 381754004970 Walker B; other site 381754004971 D-loop; other site 381754004972 H-loop/switch region; other site 381754004973 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 381754004974 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754004975 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 381754004976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754004977 substrate binding pocket [chemical binding]; other site 381754004978 membrane-bound complex binding site; other site 381754004979 hinge residues; other site 381754004980 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 381754004981 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 381754004982 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 381754004983 active site 381754004984 dimer interface [polypeptide binding]; other site 381754004985 non-prolyl cis peptide bond; other site 381754004986 insertion regions; other site 381754004987 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 381754004988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754004989 dimer interface [polypeptide binding]; other site 381754004990 conserved gate region; other site 381754004991 putative PBP binding loops; other site 381754004992 ABC-ATPase subunit interface; other site 381754004993 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 381754004994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754004995 Walker A/P-loop; other site 381754004996 ATP binding site [chemical binding]; other site 381754004997 Q-loop/lid; other site 381754004998 ABC transporter signature motif; other site 381754004999 Walker B; other site 381754005000 D-loop; other site 381754005001 H-loop/switch region; other site 381754005002 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 381754005003 HopJ type III effector protein; Region: HopJ; pfam08888 381754005004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 381754005005 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 381754005006 homooctamer interface [polypeptide binding]; other site 381754005007 active site 381754005008 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 381754005009 homodecamer interface [polypeptide binding]; other site 381754005010 GTP cyclohydrolase I; Provisional; Region: PLN03044 381754005011 active site 381754005012 putative catalytic site residues [active] 381754005013 zinc binding site [ion binding]; other site 381754005014 GTP-CH-I/GFRP interaction surface; other site 381754005015 dihydromonapterin reductase; Provisional; Region: PRK06483 381754005016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754005017 NAD(P) binding site [chemical binding]; other site 381754005018 active site 381754005019 flavodoxin; Provisional; Region: PRK05723 381754005020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754005021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754005022 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 381754005023 putative dimerization interface [polypeptide binding]; other site 381754005024 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 381754005025 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 381754005026 aldolase II superfamily protein; Provisional; Region: PRK07044 381754005027 intersubunit interface [polypeptide binding]; other site 381754005028 active site 381754005029 Zn2+ binding site [ion binding]; other site 381754005030 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754005031 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 381754005032 homodimer interface [polypeptide binding]; other site 381754005033 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 381754005034 NAD binding site [chemical binding]; other site 381754005035 active site 381754005036 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 381754005037 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754005038 substrate binding site [chemical binding]; other site 381754005039 oxyanion hole (OAH) forming residues; other site 381754005040 trimer interface [polypeptide binding]; other site 381754005041 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 381754005042 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754005043 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754005044 SnoaL-like domain; Region: SnoaL_2; pfam12680 381754005045 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754005046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754005047 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 381754005048 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 381754005049 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 381754005050 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754005051 DNA binding residues [nucleotide binding] 381754005052 dimerization interface [polypeptide binding]; other site 381754005053 Uncharacterized conserved protein [Function unknown]; Region: COG2912 381754005054 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 381754005055 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 381754005056 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 381754005057 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 381754005058 NAD binding site [chemical binding]; other site 381754005059 Phe binding site; other site 381754005060 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 381754005061 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 381754005062 TPP-binding site [chemical binding]; other site 381754005063 tetramer interface [polypeptide binding]; other site 381754005064 heterodimer interface [polypeptide binding]; other site 381754005065 phosphorylation loop region [posttranslational modification] 381754005066 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 381754005067 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 381754005068 alpha subunit interface [polypeptide binding]; other site 381754005069 TPP binding site [chemical binding]; other site 381754005070 heterodimer interface [polypeptide binding]; other site 381754005071 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 381754005072 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 381754005073 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 381754005074 E3 interaction surface; other site 381754005075 lipoyl attachment site [posttranslational modification]; other site 381754005076 e3 binding domain; Region: E3_binding; pfam02817 381754005077 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 381754005078 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 381754005079 YebG protein; Region: YebG; cl01217 381754005080 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 381754005081 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 381754005082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754005083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754005084 DNA binding residues [nucleotide binding] 381754005085 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754005086 FecR protein; Region: FecR; pfam04773 381754005087 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754005088 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 381754005089 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754005090 N-terminal plug; other site 381754005091 ligand-binding site [chemical binding]; other site 381754005092 Heme-binding protein A (HasA); Region: HasA; pfam06438 381754005093 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 381754005094 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754005095 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 381754005096 Walker A/P-loop; other site 381754005097 ATP binding site [chemical binding]; other site 381754005098 Q-loop/lid; other site 381754005099 ABC transporter signature motif; other site 381754005100 Walker B; other site 381754005101 D-loop; other site 381754005102 H-loop/switch region; other site 381754005103 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 381754005104 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754005105 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754005106 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 381754005107 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 381754005108 Predicted membrane protein [Function unknown]; Region: COG3223 381754005109 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754005110 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754005111 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754005112 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381754005113 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 381754005114 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381754005115 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 381754005116 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 381754005117 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 381754005118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754005119 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 381754005120 putative dimerization interface [polypeptide binding]; other site 381754005121 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 381754005122 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 381754005123 FAD binding pocket [chemical binding]; other site 381754005124 FAD binding motif [chemical binding]; other site 381754005125 phosphate binding motif [ion binding]; other site 381754005126 beta-alpha-beta structure motif; other site 381754005127 NAD binding pocket [chemical binding]; other site 381754005128 NosL; Region: NosL; cl01769 381754005129 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 381754005130 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 381754005131 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381754005132 Walker A/P-loop; other site 381754005133 ATP binding site [chemical binding]; other site 381754005134 Q-loop/lid; other site 381754005135 ABC transporter signature motif; other site 381754005136 Walker B; other site 381754005137 D-loop; other site 381754005138 H-loop/switch region; other site 381754005139 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 381754005140 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 381754005141 nitrous-oxide reductase; Validated; Region: PRK02888 381754005142 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 381754005143 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 381754005144 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 381754005145 4Fe-4S binding domain; Region: Fer4_5; pfam12801 381754005146 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 381754005147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754005148 active site 381754005149 metal binding site [ion binding]; metal-binding site 381754005150 Uncharacterized conserved protein [Function unknown]; Region: COG1359 381754005151 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 381754005152 homodimer interaction site [polypeptide binding]; other site 381754005153 cofactor binding site; other site 381754005154 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 381754005155 Arc-like DNA binding domain; Region: Arc; pfam03869 381754005156 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 381754005157 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 381754005158 Walker A/P-loop; other site 381754005159 ATP binding site [chemical binding]; other site 381754005160 Q-loop/lid; other site 381754005161 ABC transporter signature motif; other site 381754005162 Walker B; other site 381754005163 D-loop; other site 381754005164 H-loop/switch region; other site 381754005165 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 381754005166 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 381754005167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754005168 dimer interface [polypeptide binding]; other site 381754005169 conserved gate region; other site 381754005170 ABC-ATPase subunit interface; other site 381754005171 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 381754005172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754005173 DNA-binding site [nucleotide binding]; DNA binding site 381754005174 UTRA domain; Region: UTRA; pfam07702 381754005175 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 381754005176 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 381754005177 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 381754005178 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 381754005179 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 381754005180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754005181 Walker A/P-loop; other site 381754005182 ATP binding site [chemical binding]; other site 381754005183 Q-loop/lid; other site 381754005184 ABC transporter signature motif; other site 381754005185 Walker B; other site 381754005186 D-loop; other site 381754005187 H-loop/switch region; other site 381754005188 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 381754005189 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 381754005190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754005191 Walker A/P-loop; other site 381754005192 ATP binding site [chemical binding]; other site 381754005193 Q-loop/lid; other site 381754005194 ABC transporter signature motif; other site 381754005195 Walker B; other site 381754005196 D-loop; other site 381754005197 H-loop/switch region; other site 381754005198 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 381754005199 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 381754005200 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 381754005201 active site 381754005202 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 381754005203 Guanylate kinase; Region: Guanylate_kin; pfam00625 381754005204 active site 381754005205 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 381754005206 putative hydrolase; Provisional; Region: PRK02113 381754005207 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 381754005208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754005209 Coenzyme A binding pocket [chemical binding]; other site 381754005210 hypothetical protein; Provisional; Region: PRK10040 381754005211 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 381754005212 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 381754005213 multimer interface [polypeptide binding]; other site 381754005214 active site 381754005215 catalytic triad [active] 381754005216 dimer interface [polypeptide binding]; other site 381754005217 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 381754005218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754005219 Walker A motif; other site 381754005220 ATP binding site [chemical binding]; other site 381754005221 Walker B motif; other site 381754005222 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 381754005223 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 381754005224 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 381754005225 ligand binding site [chemical binding]; other site 381754005226 regulator interaction site; other site 381754005227 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 381754005228 ANTAR domain; Region: ANTAR; pfam03861 381754005229 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 381754005230 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 381754005231 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 381754005232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754005233 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754005234 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 381754005235 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 381754005236 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 381754005237 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754005238 catalytic residue [active] 381754005239 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 381754005240 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381754005241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754005242 putative substrate translocation pore; other site 381754005243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 381754005244 Flagellar regulator YcgR; Region: YcgR; pfam07317 381754005245 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 381754005246 PilZ domain; Region: PilZ; pfam07238 381754005247 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 381754005248 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 381754005249 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 381754005250 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 381754005251 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 381754005252 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 381754005253 Response regulator receiver domain; Region: Response_reg; pfam00072 381754005254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754005255 active site 381754005256 phosphorylation site [posttranslational modification] 381754005257 intermolecular recognition site; other site 381754005258 dimerization interface [polypeptide binding]; other site 381754005259 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 381754005260 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 381754005261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754005262 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 381754005263 anti sigma factor interaction site; other site 381754005264 regulatory phosphorylation site [posttranslational modification]; other site 381754005265 Response regulator receiver domain; Region: Response_reg; pfam00072 381754005266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754005267 active site 381754005268 phosphorylation site [posttranslational modification] 381754005269 intermolecular recognition site; other site 381754005270 dimerization interface [polypeptide binding]; other site 381754005271 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 381754005272 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 381754005273 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754005274 putative binding surface; other site 381754005275 active site 381754005276 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 381754005277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754005278 ATP binding site [chemical binding]; other site 381754005279 putative Mg++ binding site [ion binding]; other site 381754005280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754005281 nucleotide binding region [chemical binding]; other site 381754005282 ATP-binding site [chemical binding]; other site 381754005283 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 381754005284 HRDC domain; Region: HRDC; pfam00570 381754005285 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754005286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754005287 metal binding site [ion binding]; metal-binding site 381754005288 active site 381754005289 I-site; other site 381754005290 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 381754005291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 381754005292 MarR family; Region: MarR_2; pfam12802 381754005293 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754005294 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 381754005295 hypothetical protein; Provisional; Region: PRK10279 381754005296 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 381754005297 active site 381754005298 nucleophile elbow; other site 381754005299 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 381754005300 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 381754005301 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381754005302 Surface antigen; Region: Bac_surface_Ag; pfam01103 381754005303 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 381754005304 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 381754005305 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 381754005306 NADP binding site [chemical binding]; other site 381754005307 homopentamer interface [polypeptide binding]; other site 381754005308 substrate binding site [chemical binding]; other site 381754005309 active site 381754005310 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 381754005311 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 381754005312 oligomer interface [polypeptide binding]; other site 381754005313 active site residues [active] 381754005314 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 381754005315 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 381754005316 short chain dehydrogenase; Validated; Region: PRK05855 381754005317 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754005318 classical (c) SDRs; Region: SDR_c; cd05233 381754005319 NAD(P) binding site [chemical binding]; other site 381754005320 active site 381754005321 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 381754005322 active site 381754005323 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 381754005324 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 381754005325 DNA binding residues [nucleotide binding] 381754005326 putative dimer interface [polypeptide binding]; other site 381754005327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754005328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754005329 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 381754005330 putative substrate binding pocket [chemical binding]; other site 381754005331 putative dimerization interface [polypeptide binding]; other site 381754005332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 381754005333 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 381754005334 Phosphoesterase family; Region: Phosphoesterase; pfam04185 381754005335 Domain of unknown function (DUF756); Region: DUF756; pfam05506 381754005336 Domain of unknown function (DUF756); Region: DUF756; pfam05506 381754005337 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 381754005338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754005339 dimer interface [polypeptide binding]; other site 381754005340 conserved gate region; other site 381754005341 putative PBP binding loops; other site 381754005342 ABC-ATPase subunit interface; other site 381754005343 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 381754005344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 381754005345 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 381754005346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754005347 Walker A/P-loop; other site 381754005348 ATP binding site [chemical binding]; other site 381754005349 Q-loop/lid; other site 381754005350 ABC transporter signature motif; other site 381754005351 Walker B; other site 381754005352 D-loop; other site 381754005353 H-loop/switch region; other site 381754005354 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 381754005355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754005356 substrate binding pocket [chemical binding]; other site 381754005357 membrane-bound complex binding site; other site 381754005358 hinge residues; other site 381754005359 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 381754005360 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 381754005361 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 381754005362 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 381754005363 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 381754005364 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 381754005365 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754005366 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754005367 metal binding site [ion binding]; metal-binding site 381754005368 active site 381754005369 I-site; other site 381754005370 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754005371 putative metal dependent hydrolase; Provisional; Region: PRK11598 381754005372 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 381754005373 Sulfatase; Region: Sulfatase; pfam00884 381754005374 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754005375 Ligand Binding Site [chemical binding]; other site 381754005376 ATP-dependent helicase HepA; Validated; Region: PRK04914 381754005377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754005378 ATP binding site [chemical binding]; other site 381754005379 putative Mg++ binding site [ion binding]; other site 381754005380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754005381 nucleotide binding region [chemical binding]; other site 381754005382 ATP-binding site [chemical binding]; other site 381754005383 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 381754005384 Fusaric acid resistance protein family; Region: FUSC; pfam04632 381754005385 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 381754005386 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 381754005387 HlyD family secretion protein; Region: HlyD; pfam00529 381754005388 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754005389 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754005390 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 381754005391 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 381754005392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 381754005393 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 381754005394 dimer interaction site [polypeptide binding]; other site 381754005395 substrate-binding tunnel; other site 381754005396 active site 381754005397 catalytic site [active] 381754005398 substrate binding site [chemical binding]; other site 381754005399 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 381754005400 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754005401 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381754005402 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 381754005403 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 381754005404 acyl-activating enzyme (AAE) consensus motif; other site 381754005405 putative AMP binding site [chemical binding]; other site 381754005406 putative active site [active] 381754005407 putative CoA binding site [chemical binding]; other site 381754005408 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 381754005409 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 381754005410 acyl-activating enzyme (AAE) consensus motif; other site 381754005411 putative AMP binding site [chemical binding]; other site 381754005412 putative active site [active] 381754005413 putative CoA binding site [chemical binding]; other site 381754005414 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 381754005415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754005416 ATP binding site [chemical binding]; other site 381754005417 putative Mg++ binding site [ion binding]; other site 381754005418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754005419 nucleotide binding region [chemical binding]; other site 381754005420 ATP-binding site [chemical binding]; other site 381754005421 Helicase associated domain (HA2); Region: HA2; pfam04408 381754005422 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 381754005423 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 381754005424 alkaline phosphatase; Provisional; Region: PRK10518 381754005425 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 381754005426 active site 381754005427 dimer interface [polypeptide binding]; other site 381754005428 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 381754005429 HIT family signature motif; other site 381754005430 catalytic residue [active] 381754005431 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 381754005432 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 381754005433 Isochorismatase family; Region: Isochorismatase; pfam00857 381754005434 catalytic triad [active] 381754005435 conserved cis-peptide bond; other site 381754005436 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 381754005437 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 381754005438 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 381754005439 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 381754005440 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 381754005441 dimer interface [polypeptide binding]; other site 381754005442 active site 381754005443 CoA binding pocket [chemical binding]; other site 381754005444 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 381754005445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754005446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754005447 DNA binding residues [nucleotide binding] 381754005448 Putative zinc-finger; Region: zf-HC2; pfam13490 381754005449 Uncharacterized low-complexity protein [Function unknown]; Region: COG3767 381754005450 Protein of unknown function (DUF692); Region: DUF692; pfam05114 381754005451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 381754005452 Predicted membrane protein [Function unknown]; Region: COG2259 381754005453 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 381754005454 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 381754005455 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 381754005456 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 381754005457 short chain dehydrogenase; Provisional; Region: PRK05650 381754005458 classical (c) SDRs; Region: SDR_c; cd05233 381754005459 NAD(P) binding site [chemical binding]; other site 381754005460 active site 381754005461 Uncharacterized conserved protein [Function unknown]; Region: COG1742 381754005462 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 381754005463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754005464 ATP binding site [chemical binding]; other site 381754005465 putative Mg++ binding site [ion binding]; other site 381754005466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754005467 nucleotide binding region [chemical binding]; other site 381754005468 ATP-binding site [chemical binding]; other site 381754005469 DEAD/H associated; Region: DEAD_assoc; pfam08494 381754005470 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 381754005471 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 381754005472 Na binding site [ion binding]; other site 381754005473 PAS fold; Region: PAS_7; pfam12860 381754005474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754005475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754005476 dimer interface [polypeptide binding]; other site 381754005477 phosphorylation site [posttranslational modification] 381754005478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754005479 ATP binding site [chemical binding]; other site 381754005480 Mg2+ binding site [ion binding]; other site 381754005481 G-X-G motif; other site 381754005482 Response regulator receiver domain; Region: Response_reg; pfam00072 381754005483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754005484 active site 381754005485 phosphorylation site [posttranslational modification] 381754005486 intermolecular recognition site; other site 381754005487 dimerization interface [polypeptide binding]; other site 381754005488 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 381754005489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 381754005490 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754005491 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754005492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754005493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754005494 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 381754005495 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754005496 N-terminal plug; other site 381754005497 ligand-binding site [chemical binding]; other site 381754005498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754005499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754005500 putative substrate translocation pore; other site 381754005501 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 381754005502 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 381754005503 putative acyl-acceptor binding pocket; other site 381754005504 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 381754005505 DNA-binding site [nucleotide binding]; DNA binding site 381754005506 RNA-binding motif; other site 381754005507 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 381754005508 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 381754005509 Sodium Bile acid symporter family; Region: SBF; pfam01758 381754005510 recombination associated protein; Reviewed; Region: rdgC; PRK00321 381754005511 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 381754005512 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 381754005513 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 381754005514 Uncharacterized conserved protein [Function unknown]; Region: COG3339 381754005515 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 381754005516 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754005517 substrate binding pocket [chemical binding]; other site 381754005518 membrane-bound complex binding site; other site 381754005519 hinge residues; other site 381754005520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754005521 non-specific DNA binding site [nucleotide binding]; other site 381754005522 salt bridge; other site 381754005523 sequence-specific DNA binding site [nucleotide binding]; other site 381754005524 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754005525 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 381754005526 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754005527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754005528 metal binding site [ion binding]; metal-binding site 381754005529 active site 381754005530 I-site; other site 381754005531 carboxy-terminal protease; Provisional; Region: PRK11186 381754005532 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 381754005533 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 381754005534 protein binding site [polypeptide binding]; other site 381754005535 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 381754005536 Catalytic dyad [active] 381754005537 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 381754005538 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 381754005539 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 381754005540 NAD(P) binding site [chemical binding]; other site 381754005541 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 381754005542 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 381754005543 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 381754005544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754005545 Walker A/P-loop; other site 381754005546 ATP binding site [chemical binding]; other site 381754005547 Q-loop/lid; other site 381754005548 ABC transporter signature motif; other site 381754005549 Walker B; other site 381754005550 D-loop; other site 381754005551 H-loop/switch region; other site 381754005552 TOBE domain; Region: TOBE_2; pfam08402 381754005553 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381754005554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754005555 dimer interface [polypeptide binding]; other site 381754005556 conserved gate region; other site 381754005557 putative PBP binding loops; other site 381754005558 ABC-ATPase subunit interface; other site 381754005559 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381754005560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754005561 putative PBP binding loops; other site 381754005562 dimer interface [polypeptide binding]; other site 381754005563 ABC-ATPase subunit interface; other site 381754005564 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 381754005565 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381754005566 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 381754005567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754005568 DNA-binding site [nucleotide binding]; DNA binding site 381754005569 transcriptional regulator protein; Region: phnR; TIGR03337 381754005570 UTRA domain; Region: UTRA; pfam07702 381754005571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 381754005572 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 381754005573 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 381754005574 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 381754005575 active site 381754005576 metal binding site [ion binding]; metal-binding site 381754005577 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 381754005578 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 381754005579 active site 381754005580 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 381754005581 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 381754005582 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 381754005583 Switch I; other site 381754005584 Switch II; other site 381754005585 septum formation inhibitor; Reviewed; Region: minC; PRK00339 381754005586 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 381754005587 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 381754005588 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 381754005589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 381754005590 putative acyl-acceptor binding pocket; other site 381754005591 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 381754005592 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 381754005593 active site 381754005594 nucleophile elbow; other site 381754005595 Pirin-related protein [General function prediction only]; Region: COG1741 381754005596 Pirin; Region: Pirin; pfam02678 381754005597 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 381754005598 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 381754005599 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754005600 Predicted membrane protein [Function unknown]; Region: COG3205 381754005601 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 381754005602 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 381754005603 Predicted membrane protein [Function unknown]; Region: COG3162 381754005604 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 381754005605 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 381754005606 Na binding site [ion binding]; other site 381754005607 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 381754005608 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 381754005609 ligand binding site [chemical binding]; other site 381754005610 flexible hinge region; other site 381754005611 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 381754005612 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 381754005613 metal binding triad; other site 381754005614 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 381754005615 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 381754005616 active site 381754005617 catalytic site [active] 381754005618 substrate binding site [chemical binding]; other site 381754005619 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 381754005620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 381754005621 Protein of unknown function, DUF482; Region: DUF482; pfam04339 381754005622 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 381754005623 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 381754005624 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754005625 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 381754005626 Walker A/P-loop; other site 381754005627 ATP binding site [chemical binding]; other site 381754005628 Q-loop/lid; other site 381754005629 ABC transporter signature motif; other site 381754005630 Walker B; other site 381754005631 D-loop; other site 381754005632 H-loop/switch region; other site 381754005633 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 381754005634 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 381754005635 substrate binding site [chemical binding]; other site 381754005636 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 381754005637 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754005638 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 381754005639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754005640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754005641 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754005642 dimerization interface [polypeptide binding]; other site 381754005643 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 381754005644 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754005645 EamA-like transporter family; Region: EamA; pfam00892 381754005646 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 381754005647 dimer interface [polypeptide binding]; other site 381754005648 putative tRNA-binding site [nucleotide binding]; other site 381754005649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754005650 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754005651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754005652 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381754005653 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 381754005654 putative active site [active] 381754005655 putative metal binding site [ion binding]; other site 381754005656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754005657 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 381754005658 MASE2 domain; Region: MASE2; pfam05230 381754005659 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 381754005660 cyclase homology domain; Region: CHD; cd07302 381754005661 nucleotidyl binding site; other site 381754005662 metal binding site [ion binding]; metal-binding site 381754005663 dimer interface [polypeptide binding]; other site 381754005664 Protein of unknown function (DUF962); Region: DUF962; cl01879 381754005665 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754005666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754005667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754005668 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 381754005669 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 381754005670 mce related protein; Region: MCE; pfam02470 381754005671 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 381754005672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754005673 Walker A/P-loop; other site 381754005674 ATP binding site [chemical binding]; other site 381754005675 Q-loop/lid; other site 381754005676 ABC transporter signature motif; other site 381754005677 Walker B; other site 381754005678 D-loop; other site 381754005679 H-loop/switch region; other site 381754005680 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 381754005681 Permease; Region: Permease; pfam02405 381754005682 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 381754005683 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 381754005684 Flagellin N-methylase; Region: FliB; cl00497 381754005685 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 381754005686 putative FMN binding site [chemical binding]; other site 381754005687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754005688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754005689 dimerization interface [polypeptide binding]; other site 381754005690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754005691 ATP binding site [chemical binding]; other site 381754005692 Mg2+ binding site [ion binding]; other site 381754005693 G-X-G motif; other site 381754005694 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 381754005695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754005696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754005697 active site 381754005698 phosphorylation site [posttranslational modification] 381754005699 intermolecular recognition site; other site 381754005700 dimerization interface [polypeptide binding]; other site 381754005701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754005702 DNA binding site [nucleotide binding] 381754005703 YciI-like protein; Reviewed; Region: PRK11370 381754005704 intracellular septation protein A; Reviewed; Region: PRK00259 381754005705 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 381754005706 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 381754005707 active site 381754005708 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 381754005709 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 381754005710 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 381754005711 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 381754005712 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 381754005713 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 381754005714 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 381754005715 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 381754005716 phosphogluconate dehydratase; Validated; Region: PRK09054 381754005717 6-phosphogluconate dehydratase; Region: edd; TIGR01196 381754005718 glucokinase; Provisional; Region: glk; PRK00292 381754005719 glucokinase, proteobacterial type; Region: glk; TIGR00749 381754005720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754005721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754005722 active site 381754005723 phosphorylation site [posttranslational modification] 381754005724 intermolecular recognition site; other site 381754005725 dimerization interface [polypeptide binding]; other site 381754005726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754005727 DNA binding site [nucleotide binding] 381754005728 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 381754005729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754005730 ATP binding site [chemical binding]; other site 381754005731 Mg2+ binding site [ion binding]; other site 381754005732 G-X-G motif; other site 381754005733 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 381754005734 putative active site [active] 381754005735 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 381754005736 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 381754005737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754005738 dimer interface [polypeptide binding]; other site 381754005739 conserved gate region; other site 381754005740 putative PBP binding loops; other site 381754005741 ABC-ATPase subunit interface; other site 381754005742 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381754005743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754005744 dimer interface [polypeptide binding]; other site 381754005745 conserved gate region; other site 381754005746 putative PBP binding loops; other site 381754005747 ABC-ATPase subunit interface; other site 381754005748 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 381754005749 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 381754005750 Walker A/P-loop; other site 381754005751 ATP binding site [chemical binding]; other site 381754005752 Q-loop/lid; other site 381754005753 ABC transporter signature motif; other site 381754005754 Walker B; other site 381754005755 D-loop; other site 381754005756 H-loop/switch region; other site 381754005757 TOBE domain; Region: TOBE; pfam03459 381754005758 TOBE domain; Region: TOBE; pfam03459 381754005759 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 381754005760 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 381754005761 active site 381754005762 phosphate binding residues; other site 381754005763 catalytic residues [active] 381754005764 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 381754005765 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 381754005766 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 381754005767 putative active site [active] 381754005768 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 381754005769 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 381754005770 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 381754005771 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 381754005772 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 381754005773 putative active site [active] 381754005774 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 381754005775 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 381754005776 active site 381754005777 intersubunit interface [polypeptide binding]; other site 381754005778 catalytic residue [active] 381754005779 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 381754005780 nudix motif; other site 381754005781 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 381754005782 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381754005783 RNA binding surface [nucleotide binding]; other site 381754005784 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 381754005785 probable active site [active] 381754005786 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754005787 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754005788 metal binding site [ion binding]; metal-binding site 381754005789 active site 381754005790 I-site; other site 381754005791 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 381754005792 formimidoylglutamase; Provisional; Region: PRK13775 381754005793 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 381754005794 putative active site [active] 381754005795 putative metal binding site [ion binding]; other site 381754005796 Transcriptional regulator [Transcription]; Region: IclR; COG1414 381754005797 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 381754005798 Bacterial transcriptional regulator; Region: IclR; pfam01614 381754005799 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 381754005800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754005801 NAD(P) binding site [chemical binding]; other site 381754005802 active site 381754005803 phosphoglycolate phosphatase; Provisional; Region: PRK13222 381754005804 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 381754005805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754005806 motif II; other site 381754005807 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 381754005808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754005809 S-adenosylmethionine binding site [chemical binding]; other site 381754005810 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 381754005811 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 381754005812 active site 381754005813 putative substrate binding pocket [chemical binding]; other site 381754005814 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 381754005815 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 381754005816 DNA gyrase subunit A; Validated; Region: PRK05560 381754005817 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 381754005818 CAP-like domain; other site 381754005819 active site 381754005820 primary dimer interface [polypeptide binding]; other site 381754005821 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381754005822 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381754005823 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381754005824 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381754005825 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381754005826 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381754005827 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 381754005828 homodimer interface [polypeptide binding]; other site 381754005829 substrate-cofactor binding pocket; other site 381754005830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754005831 catalytic residue [active] 381754005832 Chorismate mutase type II; Region: CM_2; cl00693 381754005833 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 381754005834 Prephenate dehydratase; Region: PDT; pfam00800 381754005835 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 381754005836 putative L-Phe binding site [chemical binding]; other site 381754005837 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 381754005838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754005839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754005840 homodimer interface [polypeptide binding]; other site 381754005841 catalytic residue [active] 381754005842 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 381754005843 prephenate dehydrogenase; Validated; Region: PRK08507 381754005844 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 381754005845 hinge; other site 381754005846 active site 381754005847 cytidylate kinase; Provisional; Region: cmk; PRK00023 381754005848 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 381754005849 CMP-binding site; other site 381754005850 The sites determining sugar specificity; other site 381754005851 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 381754005852 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 381754005853 RNA binding site [nucleotide binding]; other site 381754005854 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 381754005855 RNA binding site [nucleotide binding]; other site 381754005856 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 381754005857 RNA binding site [nucleotide binding]; other site 381754005858 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 381754005859 RNA binding site [nucleotide binding]; other site 381754005860 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 381754005861 RNA binding site [nucleotide binding]; other site 381754005862 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 381754005863 RNA binding site [nucleotide binding]; other site 381754005864 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 381754005865 IHF dimer interface [polypeptide binding]; other site 381754005866 IHF - DNA interface [nucleotide binding]; other site 381754005867 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 381754005868 Chain length determinant protein; Region: Wzz; pfam02706 381754005869 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 381754005870 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 381754005871 NAD binding site [chemical binding]; other site 381754005872 substrate binding site [chemical binding]; other site 381754005873 active site 381754005874 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 381754005875 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 381754005876 active site 381754005877 homodimer interface [polypeptide binding]; other site 381754005878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 381754005879 flagellin modification protein A; Provisional; Region: PRK09186 381754005880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754005881 NAD(P) binding site [chemical binding]; other site 381754005882 active site 381754005883 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 381754005884 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 381754005885 Ligand Binding Site [chemical binding]; other site 381754005886 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 381754005887 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 381754005888 substrate binding site [chemical binding]; other site 381754005889 glutamase interaction surface [polypeptide binding]; other site 381754005890 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 381754005891 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 381754005892 NAD(P) binding site [chemical binding]; other site 381754005893 homodimer interface [polypeptide binding]; other site 381754005894 substrate binding site [chemical binding]; other site 381754005895 active site 381754005896 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 381754005897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754005898 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 381754005899 NAD(P) binding site [chemical binding]; other site 381754005900 active site 381754005901 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 381754005902 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 381754005903 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 381754005904 active site 381754005905 homodimer interface [polypeptide binding]; other site 381754005906 putative glycosyl transferase; Provisional; Region: PRK10307 381754005907 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 381754005908 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 381754005909 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 381754005910 putative NAD(P) binding site [chemical binding]; other site 381754005911 active site 381754005912 putative substrate binding site [chemical binding]; other site 381754005913 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 381754005914 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 381754005915 Mg++ binding site [ion binding]; other site 381754005916 putative catalytic motif [active] 381754005917 putative substrate binding site [chemical binding]; other site 381754005918 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 381754005919 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 381754005920 NAD(P) binding site [chemical binding]; other site 381754005921 homodimer interface [polypeptide binding]; other site 381754005922 substrate binding site [chemical binding]; other site 381754005923 active site 381754005924 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 381754005925 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 381754005926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754005927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754005928 homodimer interface [polypeptide binding]; other site 381754005929 catalytic residue [active] 381754005930 excinuclease ABC subunit B; Provisional; Region: PRK05298 381754005931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754005932 ATP binding site [chemical binding]; other site 381754005933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754005934 nucleotide binding region [chemical binding]; other site 381754005935 ATP-binding site [chemical binding]; other site 381754005936 Ultra-violet resistance protein B; Region: UvrB; pfam12344 381754005937 UvrB/uvrC motif; Region: UVR; pfam02151 381754005938 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 381754005939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754005940 putative substrate translocation pore; other site 381754005941 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 381754005942 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754005943 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754005944 LysR family transcriptional regulator; Provisional; Region: PRK14997 381754005945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754005946 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754005947 putative effector binding pocket; other site 381754005948 dimerization interface [polypeptide binding]; other site 381754005949 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 381754005950 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 381754005951 HIGH motif; other site 381754005952 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 381754005953 active site 381754005954 KMSKS motif; other site 381754005955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754005956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754005957 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 381754005958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754005959 Entner-Doudoroff aldolase; Region: eda; TIGR01182 381754005960 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 381754005961 active site 381754005962 intersubunit interface [polypeptide binding]; other site 381754005963 catalytic residue [active] 381754005964 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 381754005965 active site 381754005966 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 381754005967 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 381754005968 FMN binding site [chemical binding]; other site 381754005969 active site 381754005970 catalytic residues [active] 381754005971 substrate binding site [chemical binding]; other site 381754005972 short chain dehydrogenase; Provisional; Region: PRK06123 381754005973 classical (c) SDRs; Region: SDR_c; cd05233 381754005974 NAD(P) binding site [chemical binding]; other site 381754005975 active site 381754005976 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 381754005977 dimer interface [polypeptide binding]; other site 381754005978 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754005979 ligand binding site [chemical binding]; other site 381754005980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754005981 Coenzyme A binding pocket [chemical binding]; other site 381754005982 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 381754005983 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 381754005984 putative dimer interface [polypeptide binding]; other site 381754005985 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754005986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754005987 non-specific DNA binding site [nucleotide binding]; other site 381754005988 salt bridge; other site 381754005989 sequence-specific DNA binding site [nucleotide binding]; other site 381754005990 Cupin domain; Region: Cupin_2; pfam07883 381754005991 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754005992 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381754005993 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 381754005994 homotrimer interaction site [polypeptide binding]; other site 381754005995 putative active site [active] 381754005996 Uncharacterized membrane protein [Function unknown]; Region: COG3949 381754005997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754005998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754005999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754006000 dimerization interface [polypeptide binding]; other site 381754006001 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 381754006002 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 381754006003 substrate binding site [chemical binding]; other site 381754006004 ligand binding site [chemical binding]; other site 381754006005 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 381754006006 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 381754006007 substrate binding site [chemical binding]; other site 381754006008 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754006009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754006010 S-adenosylmethionine binding site [chemical binding]; other site 381754006011 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 381754006012 tartrate dehydrogenase; Region: TTC; TIGR02089 381754006013 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 381754006014 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 381754006015 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 381754006016 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 381754006017 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 381754006018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754006019 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 381754006020 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 381754006021 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 381754006022 dimerization interface 3.5A [polypeptide binding]; other site 381754006023 active site 381754006024 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 381754006025 active site 381754006026 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 381754006027 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 381754006028 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 381754006029 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381754006030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 381754006031 Sporulation related domain; Region: SPOR; pfam05036 381754006032 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 381754006033 Colicin V production protein; Region: Colicin_V; cl00567 381754006034 amidophosphoribosyltransferase; Provisional; Region: PRK09246 381754006035 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 381754006036 active site 381754006037 tetramer interface [polypeptide binding]; other site 381754006038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754006039 active site 381754006040 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 381754006041 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 381754006042 homodimer interface [polypeptide binding]; other site 381754006043 substrate-cofactor binding pocket; other site 381754006044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754006045 catalytic residue [active] 381754006046 oxidoreductase; Validated; Region: PRK05717 381754006047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754006048 NAD(P) binding site [chemical binding]; other site 381754006049 active site 381754006050 type II secretion system protein D; Region: type_II_gspD; TIGR02517 381754006051 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754006052 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754006053 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754006054 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381754006055 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 381754006056 type II secretion system protein E; Region: type_II_gspE; TIGR02533 381754006057 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 381754006058 Walker A motif; other site 381754006059 ATP binding site [chemical binding]; other site 381754006060 Walker B motif; other site 381754006061 type II secretion system protein F; Region: GspF; TIGR02120 381754006062 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754006063 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754006064 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 381754006065 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 381754006066 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 381754006067 type II secretion system protein I; Region: gspI; TIGR01707 381754006068 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 381754006069 type II secretion system protein J; Region: gspJ; TIGR01711 381754006070 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 381754006071 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 381754006072 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 381754006073 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 381754006074 GspL periplasmic domain; Region: GspL_C; pfam12693 381754006075 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 381754006076 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754006077 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754006078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754006079 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 381754006080 active site 381754006081 catalytic triad [active] 381754006082 Predicted amidohydrolase [General function prediction only]; Region: COG0388 381754006083 dimer interface [polypeptide binding]; other site 381754006084 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 381754006085 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 381754006086 active site 381754006087 FMN binding site [chemical binding]; other site 381754006088 2,4-decadienoyl-CoA binding site; other site 381754006089 catalytic residue [active] 381754006090 4Fe-4S cluster binding site [ion binding]; other site 381754006091 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 381754006092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754006093 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 381754006094 1-aminocyclopropane-1-carboxylate deaminase; Provisional; Region: PRK14045 381754006095 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 381754006096 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 381754006097 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 381754006098 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 381754006099 active site 381754006100 metal binding site [ion binding]; metal-binding site 381754006101 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 381754006102 Rhomboid family; Region: Rhomboid; pfam01694 381754006103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 381754006104 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 381754006105 aminopeptidase N; Provisional; Region: pepN; PRK14015 381754006106 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 381754006107 active site 381754006108 Zn binding site [ion binding]; other site 381754006109 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 381754006110 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 381754006111 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 381754006112 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 381754006113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754006114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754006115 dimer interface [polypeptide binding]; other site 381754006116 phosphorylation site [posttranslational modification] 381754006117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754006118 ATP binding site [chemical binding]; other site 381754006119 Mg2+ binding site [ion binding]; other site 381754006120 G-X-G motif; other site 381754006121 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754006122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754006123 active site 381754006124 phosphorylation site [posttranslational modification] 381754006125 intermolecular recognition site; other site 381754006126 dimerization interface [polypeptide binding]; other site 381754006127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754006128 DNA binding site [nucleotide binding] 381754006129 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 381754006130 catalytic triad [active] 381754006131 putative active site [active] 381754006132 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 381754006133 Autotransporter beta-domain; Region: Autotransporter; pfam03797 381754006134 Oxygen tolerance; Region: BatD; pfam13584 381754006135 von Willebrand factor type A domain; Region: VWA_2; pfam13519 381754006136 metal ion-dependent adhesion site (MIDAS); other site 381754006137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754006138 TPR repeat; Region: TPR_11; pfam13414 381754006139 binding surface 381754006140 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 381754006141 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 381754006142 metal ion-dependent adhesion site (MIDAS); other site 381754006143 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 381754006144 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 381754006145 Protein of unknown function DUF58; Region: DUF58; pfam01882 381754006146 MoxR-like ATPases [General function prediction only]; Region: COG0714 381754006147 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 381754006148 Walker A motif; other site 381754006149 ATP binding site [chemical binding]; other site 381754006150 Walker B motif; other site 381754006151 arginine finger; other site 381754006152 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 381754006153 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 381754006154 Uncharacterized conserved protein [Function unknown]; Region: COG3868 381754006155 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 381754006156 putative active site [active] 381754006157 Tetratricopeptide repeat; Region: TPR_15; pfam13429 381754006158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754006159 binding surface 381754006160 TPR motif; other site 381754006161 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 381754006162 GAF domain; Region: GAF_3; pfam13492 381754006163 HEAT repeats; Region: HEAT_2; pfam13646 381754006164 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 381754006165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754006166 Predicted membrane protein [Function unknown]; Region: COG4267 381754006167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754006168 non-specific DNA binding site [nucleotide binding]; other site 381754006169 salt bridge; other site 381754006170 sequence-specific DNA binding site [nucleotide binding]; other site 381754006171 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 381754006172 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 381754006173 putative active site [active] 381754006174 Zn binding site [ion binding]; other site 381754006175 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754006176 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754006177 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 381754006178 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 381754006179 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 381754006180 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 381754006181 quinone interaction residues [chemical binding]; other site 381754006182 active site 381754006183 catalytic residues [active] 381754006184 FMN binding site [chemical binding]; other site 381754006185 substrate binding site [chemical binding]; other site 381754006186 Ribosome modulation factor [Translation, ribosomal structure and biogenesis]; Region: Rmf; COG3130 381754006187 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 381754006188 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 381754006189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 381754006190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754006191 S-adenosylmethionine binding site [chemical binding]; other site 381754006192 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 381754006193 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 381754006194 hypothetical protein; Provisional; Region: PRK11702 381754006195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754006196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754006197 active site 381754006198 phosphorylation site [posttranslational modification] 381754006199 intermolecular recognition site; other site 381754006200 dimerization interface [polypeptide binding]; other site 381754006201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754006202 DNA binding residues [nucleotide binding] 381754006203 dimerization interface [polypeptide binding]; other site 381754006204 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 381754006205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754006206 dimer interface [polypeptide binding]; other site 381754006207 phosphorylation site [posttranslational modification] 381754006208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754006209 ATP binding site [chemical binding]; other site 381754006210 Mg2+ binding site [ion binding]; other site 381754006211 G-X-G motif; other site 381754006212 Response regulator receiver domain; Region: Response_reg; pfam00072 381754006213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754006214 active site 381754006215 phosphorylation site [posttranslational modification] 381754006216 intermolecular recognition site; other site 381754006217 dimerization interface [polypeptide binding]; other site 381754006218 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 381754006219 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 381754006220 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754006221 Zn2+ binding site [ion binding]; other site 381754006222 Mg2+ binding site [ion binding]; other site 381754006223 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 381754006224 Predicted membrane protein [Function unknown]; Region: COG5393 381754006225 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 381754006226 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 381754006227 outer membrane porin, OprD family; Region: OprD; pfam03573 381754006228 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381754006229 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 381754006230 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754006231 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 381754006232 putative C-terminal domain interface [polypeptide binding]; other site 381754006233 putative GSH binding site (G-site) [chemical binding]; other site 381754006234 putative dimer interface [polypeptide binding]; other site 381754006235 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 381754006236 putative N-terminal domain interface [polypeptide binding]; other site 381754006237 putative dimer interface [polypeptide binding]; other site 381754006238 putative substrate binding pocket (H-site) [chemical binding]; other site 381754006239 putative transcriptional regulator; Provisional; Region: PRK11640 381754006240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754006241 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 381754006242 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 381754006243 Cytochrome c; Region: Cytochrom_C; pfam00034 381754006244 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 381754006245 putative hydrophobic ligand binding site [chemical binding]; other site 381754006246 protein interface [polypeptide binding]; other site 381754006247 gate; other site 381754006248 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754006249 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 381754006250 acyl-activating enzyme (AAE) consensus motif; other site 381754006251 AMP binding site [chemical binding]; other site 381754006252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754006253 thioester reductase domain; Region: Thioester-redct; TIGR01746 381754006254 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 381754006255 putative NAD(P) binding site [chemical binding]; other site 381754006256 active site 381754006257 putative substrate binding site [chemical binding]; other site 381754006258 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 381754006259 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 381754006260 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 381754006261 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 381754006262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754006263 putative substrate translocation pore; other site 381754006264 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 381754006265 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 381754006266 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754006267 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 381754006268 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754006269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754006270 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754006271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754006272 2-isopropylmalate synthase; Validated; Region: PRK03739 381754006273 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 381754006274 active site 381754006275 catalytic residues [active] 381754006276 metal binding site [ion binding]; metal-binding site 381754006277 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 381754006278 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754006279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754006280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754006281 active site 381754006282 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 381754006283 putative deacylase active site [active] 381754006284 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 381754006285 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 381754006286 acyl-activating enzyme (AAE) consensus motif; other site 381754006287 AMP binding site [chemical binding]; other site 381754006288 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 381754006289 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754006290 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 381754006291 Transcriptional regulators [Transcription]; Region: FadR; COG2186 381754006292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754006293 DNA-binding site [nucleotide binding]; DNA binding site 381754006294 FCD domain; Region: FCD; pfam07729 381754006295 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 381754006296 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 381754006297 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 381754006298 GTP binding site; other site 381754006299 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 381754006300 MPT binding site; other site 381754006301 trimer interface [polypeptide binding]; other site 381754006302 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 381754006303 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 381754006304 dimer interface [polypeptide binding]; other site 381754006305 putative functional site; other site 381754006306 putative MPT binding site; other site 381754006307 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754006308 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754006309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754006310 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 381754006311 FAD binding domain; Region: FAD_binding_4; pfam01565 381754006312 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 381754006313 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 381754006314 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 381754006315 putative N- and C-terminal domain interface [polypeptide binding]; other site 381754006316 putative active site [active] 381754006317 MgATP binding site [chemical binding]; other site 381754006318 catalytic site [active] 381754006319 metal binding site [ion binding]; metal-binding site 381754006320 putative carbohydrate binding site [chemical binding]; other site 381754006321 lipid kinase; Reviewed; Region: PRK13054 381754006322 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 381754006323 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 381754006324 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 381754006325 MOSC domain; Region: MOSC; pfam03473 381754006326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 381754006327 lytic murein transglycosylase; Provisional; Region: PRK11619 381754006328 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754006329 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754006330 catalytic residue [active] 381754006331 ABC transporter ATPase component; Reviewed; Region: PRK11147 381754006332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754006333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754006334 ABC transporter; Region: ABC_tran_2; pfam12848 381754006335 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754006336 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754006337 Ligand Binding Site [chemical binding]; other site 381754006338 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 381754006339 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 381754006340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754006341 substrate binding site [chemical binding]; other site 381754006342 oxyanion hole (OAH) forming residues; other site 381754006343 trimer interface [polypeptide binding]; other site 381754006344 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381754006345 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754006346 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 381754006347 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754006348 dimer interface [polypeptide binding]; other site 381754006349 active site 381754006350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4728 381754006351 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 381754006352 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 381754006353 active site 381754006354 interdomain interaction site; other site 381754006355 putative metal-binding site [ion binding]; other site 381754006356 nucleotide binding site [chemical binding]; other site 381754006357 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 381754006358 domain I; other site 381754006359 DNA binding groove [nucleotide binding] 381754006360 phosphate binding site [ion binding]; other site 381754006361 domain II; other site 381754006362 domain III; other site 381754006363 nucleotide binding site [chemical binding]; other site 381754006364 catalytic site [active] 381754006365 domain IV; other site 381754006366 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 381754006367 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 381754006368 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 381754006369 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 381754006370 Cell division inhibitor SulA; Region: SulA; cl01880 381754006371 LexA repressor; Validated; Region: PRK00215 381754006372 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 381754006373 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 381754006374 Catalytic site [active] 381754006375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754006376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754006377 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 381754006378 beta-hexosaminidase; Provisional; Region: PRK05337 381754006379 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 381754006380 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 381754006381 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 381754006382 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 381754006383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754006384 ATP binding site [chemical binding]; other site 381754006385 putative Mg++ binding site [ion binding]; other site 381754006386 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754006387 nucleotide binding region [chemical binding]; other site 381754006388 ATP-binding site [chemical binding]; other site 381754006389 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 381754006390 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 381754006391 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 381754006392 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 381754006393 aromatic amino acid transporter; Provisional; Region: PRK10238 381754006394 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 381754006395 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 381754006396 E3 interaction surface; other site 381754006397 lipoyl attachment site [posttranslational modification]; other site 381754006398 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 381754006399 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 381754006400 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 381754006401 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 381754006402 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 381754006403 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 381754006404 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 381754006405 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754006406 catalytic loop [active] 381754006407 iron binding site [ion binding]; other site 381754006408 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 381754006409 FAD binding pocket [chemical binding]; other site 381754006410 FAD binding motif [chemical binding]; other site 381754006411 phosphate binding motif [ion binding]; other site 381754006412 beta-alpha-beta structure motif; other site 381754006413 NAD binding pocket [chemical binding]; other site 381754006414 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 381754006415 ApbE family; Region: ApbE; pfam02424 381754006416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 381754006417 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 381754006418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754006419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754006420 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 381754006421 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 381754006422 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 381754006423 active site 381754006424 catalytic site [active] 381754006425 metal binding site [ion binding]; metal-binding site 381754006426 PilZ domain; Region: PilZ; pfam07238 381754006427 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 381754006428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 381754006429 FtsX-like permease family; Region: FtsX; pfam02687 381754006430 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 381754006431 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 381754006432 Walker A/P-loop; other site 381754006433 ATP binding site [chemical binding]; other site 381754006434 Q-loop/lid; other site 381754006435 ABC transporter signature motif; other site 381754006436 Walker B; other site 381754006437 D-loop; other site 381754006438 H-loop/switch region; other site 381754006439 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 381754006440 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 381754006441 FtsX-like permease family; Region: FtsX; pfam02687 381754006442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 381754006443 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 381754006444 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 381754006445 Competence protein; Region: Competence; pfam03772 381754006446 Competence protein; Region: Competence; cl00471 381754006447 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 381754006448 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 381754006449 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 381754006450 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 381754006451 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 381754006452 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 381754006453 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 381754006454 Uncharacterized conserved protein [Function unknown]; Region: COG2835 381754006455 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 381754006456 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 381754006457 Ligand binding site; other site 381754006458 oligomer interface; other site 381754006459 Low molecular weight phosphatase family; Region: LMWPc; cd00115 381754006460 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 381754006461 active site 381754006462 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 381754006463 FAD binding domain; Region: FAD_binding_4; pfam01565 381754006464 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 381754006465 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 381754006466 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 381754006467 homodimer interface [polypeptide binding]; other site 381754006468 oligonucleotide binding site [chemical binding]; other site 381754006469 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 381754006470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381754006471 RNA binding surface [nucleotide binding]; other site 381754006472 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 381754006473 active site 381754006474 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 381754006475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754006476 motif II; other site 381754006477 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 381754006478 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 381754006479 tandem repeat interface [polypeptide binding]; other site 381754006480 oligomer interface [polypeptide binding]; other site 381754006481 active site residues [active] 381754006482 Maf-like protein; Region: Maf; pfam02545 381754006483 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 381754006484 active site 381754006485 dimer interface [polypeptide binding]; other site 381754006486 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 381754006487 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 381754006488 putative phosphate acyltransferase; Provisional; Region: PRK05331 381754006489 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 381754006490 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 381754006491 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 381754006492 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 381754006493 NAD(P) binding site [chemical binding]; other site 381754006494 homotetramer interface [polypeptide binding]; other site 381754006495 homodimer interface [polypeptide binding]; other site 381754006496 active site 381754006497 acyl carrier protein; Provisional; Region: acpP; PRK00982 381754006498 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 381754006499 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 381754006500 dimer interface [polypeptide binding]; other site 381754006501 active site 381754006502 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 381754006503 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 381754006504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754006505 catalytic residue [active] 381754006506 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 381754006507 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 381754006508 dimerization interface [polypeptide binding]; other site 381754006509 thymidylate kinase; Validated; Region: tmk; PRK00698 381754006510 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 381754006511 TMP-binding site; other site 381754006512 ATP-binding site [chemical binding]; other site 381754006513 DNA polymerase III subunit delta'; Validated; Region: PRK05707 381754006514 DNA polymerase III subunit delta'; Validated; Region: PRK08485 381754006515 Tfp pilus assembly protein PilZ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilZ; COG3215 381754006516 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 381754006517 active site 381754006518 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 381754006519 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 381754006520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754006521 catalytic residue [active] 381754006522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754006523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754006524 WHG domain; Region: WHG; pfam13305 381754006525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754006526 Radical SAM superfamily; Region: Radical_SAM; pfam04055 381754006527 FeS/SAM binding site; other site 381754006528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 381754006529 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 381754006530 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 381754006531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381754006532 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 381754006533 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 381754006534 Ligand binding site [chemical binding]; other site 381754006535 Electron transfer flavoprotein domain; Region: ETF; pfam01012 381754006536 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 381754006537 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 381754006538 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 381754006539 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 381754006540 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 381754006541 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 381754006542 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 381754006543 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754006544 nucleophilic elbow; other site 381754006545 catalytic triad; other site 381754006546 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 381754006547 active site 381754006548 SAM binding site [chemical binding]; other site 381754006549 homodimer interface [polypeptide binding]; other site 381754006550 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 381754006551 Predicted integral membrane protein [Function unknown]; Region: COG5446 381754006552 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 381754006553 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 381754006554 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 381754006555 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 381754006556 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 381754006557 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 381754006558 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 381754006559 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 381754006560 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 381754006561 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 381754006562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754006563 Walker A motif; other site 381754006564 ATP binding site [chemical binding]; other site 381754006565 Walker B motif; other site 381754006566 arginine finger; other site 381754006567 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 381754006568 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 381754006569 metal ion-dependent adhesion site (MIDAS); other site 381754006570 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 381754006571 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 381754006572 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 381754006573 PA/protease or protease-like domain interface [polypeptide binding]; other site 381754006574 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 381754006575 active site 381754006576 metal binding site [ion binding]; metal-binding site 381754006577 xanthine permease; Region: pbuX; TIGR03173 381754006578 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 381754006579 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 381754006580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754006581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754006582 dimerization interface [polypeptide binding]; other site 381754006583 LysE type translocator; Region: LysE; cl00565 381754006584 Serine hydrolase; Region: Ser_hydrolase; cl17834 381754006585 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754006586 HAMP domain; Region: HAMP; pfam00672 381754006587 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 381754006588 dimerization interface [polypeptide binding]; other site 381754006589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754006590 dimer interface [polypeptide binding]; other site 381754006591 putative CheW interface [polypeptide binding]; other site 381754006592 short chain dehydrogenase; Provisional; Region: PRK12744 381754006593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754006594 NAD(P) binding site [chemical binding]; other site 381754006595 active site 381754006596 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754006597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754006598 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754006599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754006600 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754006601 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 381754006602 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 381754006603 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 381754006604 ABC-ATPase subunit interface; other site 381754006605 dimer interface [polypeptide binding]; other site 381754006606 putative PBP binding regions; other site 381754006607 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 381754006608 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 381754006609 putative ligand binding residues [chemical binding]; other site 381754006610 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 381754006611 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 381754006612 Walker A/P-loop; other site 381754006613 ATP binding site [chemical binding]; other site 381754006614 Q-loop/lid; other site 381754006615 ABC transporter signature motif; other site 381754006616 Walker B; other site 381754006617 D-loop; other site 381754006618 H-loop/switch region; other site 381754006619 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 381754006620 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754006621 N-terminal plug; other site 381754006622 ligand-binding site [chemical binding]; other site 381754006623 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 381754006624 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 381754006625 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 381754006626 active site 381754006627 putative homodimer interface [polypeptide binding]; other site 381754006628 SAM binding site [chemical binding]; other site 381754006629 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 381754006630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754006631 S-adenosylmethionine binding site [chemical binding]; other site 381754006632 precorrin-3B synthase; Region: CobG; TIGR02435 381754006633 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 381754006634 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 381754006635 Precorrin-8X methylmutase; Region: CbiC; pfam02570 381754006636 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 381754006637 active site 381754006638 SAM binding site [chemical binding]; other site 381754006639 homodimer interface [polypeptide binding]; other site 381754006640 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 381754006641 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 381754006642 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 381754006643 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 381754006644 active site 381754006645 SAM binding site [chemical binding]; other site 381754006646 homodimer interface [polypeptide binding]; other site 381754006647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754006648 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754006649 substrate binding pocket [chemical binding]; other site 381754006650 membrane-bound complex binding site; other site 381754006651 hinge residues; other site 381754006652 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 381754006653 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754006654 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754006655 ligand binding site [chemical binding]; other site 381754006656 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754006657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754006658 active site 381754006659 phosphorylation site [posttranslational modification] 381754006660 intermolecular recognition site; other site 381754006661 dimerization interface [polypeptide binding]; other site 381754006662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754006663 DNA binding residues [nucleotide binding] 381754006664 dimerization interface [polypeptide binding]; other site 381754006665 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754006666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754006667 DNA-binding site [nucleotide binding]; DNA binding site 381754006668 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754006669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754006670 homodimer interface [polypeptide binding]; other site 381754006671 catalytic residue [active] 381754006672 RNA polymerase sigma factor; Provisional; Region: PRK12513 381754006673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754006674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754006675 DNA binding residues [nucleotide binding] 381754006676 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 381754006677 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754006678 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754006679 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 381754006680 acyl-activating enzyme (AAE) consensus motif; other site 381754006681 acyl-activating enzyme (AAE) consensus motif; other site 381754006682 putative AMP binding site [chemical binding]; other site 381754006683 putative active site [active] 381754006684 putative CoA binding site [chemical binding]; other site 381754006685 short chain dehydrogenase; Provisional; Region: PRK08278 381754006686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754006687 NAD(P) binding site [chemical binding]; other site 381754006688 active site 381754006689 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 381754006690 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 381754006691 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 381754006692 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 381754006693 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 381754006694 carboxyltransferase (CT) interaction site; other site 381754006695 biotinylation site [posttranslational modification]; other site 381754006696 enoyl-CoA hydratase; Provisional; Region: PRK05995 381754006697 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754006698 substrate binding site [chemical binding]; other site 381754006699 oxyanion hole (OAH) forming residues; other site 381754006700 trimer interface [polypeptide binding]; other site 381754006701 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754006702 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754006703 active site 381754006704 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 381754006705 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 381754006706 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 381754006707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754006708 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 381754006709 NAD(P) binding site [chemical binding]; other site 381754006710 active site 381754006711 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 381754006712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754006713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754006714 CAAX protease self-immunity; Region: Abi; pfam02517 381754006715 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 381754006716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 381754006717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754006718 ATP binding site [chemical binding]; other site 381754006719 Mg2+ binding site [ion binding]; other site 381754006720 G-X-G motif; other site 381754006721 Response regulator receiver domain; Region: Response_reg; pfam00072 381754006722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754006723 active site 381754006724 phosphorylation site [posttranslational modification] 381754006725 intermolecular recognition site; other site 381754006726 dimerization interface [polypeptide binding]; other site 381754006727 Predicted membrane protein [Function unknown]; Region: COG4125 381754006728 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 381754006729 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 381754006730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754006731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754006732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754006733 dimerization interface [polypeptide binding]; other site 381754006734 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 381754006735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754006736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754006737 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 381754006738 putative effector binding pocket; other site 381754006739 putative dimerization interface [polypeptide binding]; other site 381754006740 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 381754006741 active site 381754006742 dimer interface [polypeptide binding]; other site 381754006743 MoxR-like ATPases [General function prediction only]; Region: COG0714 381754006744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754006745 Walker A motif; other site 381754006746 ATP binding site [chemical binding]; other site 381754006747 Walker B motif; other site 381754006748 arginine finger; other site 381754006749 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 381754006750 Protein of unknown function DUF58; Region: DUF58; pfam01882 381754006751 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 381754006752 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 381754006753 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 381754006754 Uncharacterized conserved protein [Function unknown]; Region: COG5607 381754006755 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 381754006756 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 381754006757 active site 381754006758 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 381754006759 active site 2 [active] 381754006760 active site 1 [active] 381754006761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754006762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754006763 metal binding site [ion binding]; metal-binding site 381754006764 active site 381754006765 I-site; other site 381754006766 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 381754006767 Terminase small subunit; Region: Terminase_2; cl01513 381754006768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754006769 dimerization interface [polypeptide binding]; other site 381754006770 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754006771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754006772 dimer interface [polypeptide binding]; other site 381754006773 putative CheW interface [polypeptide binding]; other site 381754006774 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 381754006775 active site 381754006776 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754006777 substrate binding pocket [chemical binding]; other site 381754006778 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 381754006779 membrane-bound complex binding site; other site 381754006780 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 381754006781 hinge residues; other site 381754006782 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754006783 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754006784 catalytic residue [active] 381754006785 Predicted membrane protein [Function unknown]; Region: COG2259 381754006786 lipase chaperone; Provisional; Region: PRK01294 381754006787 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 381754006788 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 381754006789 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 381754006790 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 381754006791 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 381754006792 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 381754006793 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 381754006794 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 381754006795 Walker A/P-loop; other site 381754006796 ATP binding site [chemical binding]; other site 381754006797 Q-loop/lid; other site 381754006798 ABC transporter signature motif; other site 381754006799 Walker B; other site 381754006800 D-loop; other site 381754006801 H-loop/switch region; other site 381754006802 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 381754006803 active site 381754006804 catalytic triad [active] 381754006805 oxyanion hole [active] 381754006806 switch loop; other site 381754006807 L,D-transpeptidase; Provisional; Region: PRK10260 381754006808 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 381754006809 Protein of unknown function (DUF3359); Region: DUF3359; pfam11839 381754006810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 381754006811 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 381754006812 elongation factor P; Validated; Region: PRK00529 381754006813 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 381754006814 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 381754006815 RNA binding site [nucleotide binding]; other site 381754006816 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 381754006817 RNA binding site [nucleotide binding]; other site 381754006818 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 381754006819 Transcriptional regulators [Transcription]; Region: MarR; COG1846 381754006820 MarR family; Region: MarR; pfam01047 381754006821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754006822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754006823 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754006824 putative effector binding pocket; other site 381754006825 dimerization interface [polypeptide binding]; other site 381754006826 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 381754006827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754006828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754006829 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754006830 dimerization interface [polypeptide binding]; other site 381754006831 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 381754006832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 381754006833 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 381754006834 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 381754006835 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 381754006836 enoyl-CoA hydratase; Provisional; Region: PRK06563 381754006837 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754006838 substrate binding site [chemical binding]; other site 381754006839 oxyanion hole (OAH) forming residues; other site 381754006840 trimer interface [polypeptide binding]; other site 381754006841 helicase 45; Provisional; Region: PTZ00424 381754006842 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 381754006843 ATP binding site [chemical binding]; other site 381754006844 Mg++ binding site [ion binding]; other site 381754006845 motif III; other site 381754006846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754006847 nucleotide binding region [chemical binding]; other site 381754006848 ATP-binding site [chemical binding]; other site 381754006849 DbpA RNA binding domain; Region: DbpA; pfam03880 381754006850 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 381754006851 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 381754006852 putative active site [active] 381754006853 metal binding site [ion binding]; metal-binding site 381754006854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754006855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754006856 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754006857 putative effector binding pocket; other site 381754006858 dimerization interface [polypeptide binding]; other site 381754006859 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 381754006860 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 381754006861 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754006862 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754006863 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 381754006864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754006865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754006866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754006867 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 381754006868 putative substrate binding pocket [chemical binding]; other site 381754006869 putative dimerization interface [polypeptide binding]; other site 381754006870 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754006871 Ligand Binding Site [chemical binding]; other site 381754006872 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 381754006873 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 381754006874 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 381754006875 putative active site [active] 381754006876 Zn binding site [ion binding]; other site 381754006877 heat shock protein HtpX; Provisional; Region: PRK05457 381754006878 aminotransferase AlaT; Validated; Region: PRK09265 381754006879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754006880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754006881 homodimer interface [polypeptide binding]; other site 381754006882 catalytic residue [active] 381754006883 methionine sulfoxide reductase B; Provisional; Region: PRK00222 381754006884 SelR domain; Region: SelR; pfam01641 381754006885 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 381754006886 catalytic residues [active] 381754006887 dimer interface [polypeptide binding]; other site 381754006888 MarR family; Region: MarR_2; cl17246 381754006889 Transcriptional regulators [Transcription]; Region: MarR; COG1846 381754006890 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 381754006891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754006892 ATP binding site [chemical binding]; other site 381754006893 Mg2+ binding site [ion binding]; other site 381754006894 G-X-G motif; other site 381754006895 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381754006896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754006897 active site 381754006898 phosphorylation site [posttranslational modification] 381754006899 intermolecular recognition site; other site 381754006900 dimerization interface [polypeptide binding]; other site 381754006901 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 381754006902 Protein of unknown function (DUF815); Region: DUF815; pfam05673 381754006903 Walker A motif; other site 381754006904 ATP binding site [chemical binding]; other site 381754006905 Walker B motif; other site 381754006906 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 381754006907 GAF domain; Region: GAF_2; pfam13185 381754006908 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754006909 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 381754006910 C-terminal domain interface [polypeptide binding]; other site 381754006911 GSH binding site (G-site) [chemical binding]; other site 381754006912 dimer interface [polypeptide binding]; other site 381754006913 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 381754006914 N-terminal domain interface [polypeptide binding]; other site 381754006915 dimer interface [polypeptide binding]; other site 381754006916 substrate binding pocket (H-site) [chemical binding]; other site 381754006917 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 381754006918 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 381754006919 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754006920 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 381754006921 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 381754006922 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 381754006923 active site 381754006924 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 381754006925 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 381754006926 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 381754006927 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754006928 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 381754006929 putative C-terminal domain interface [polypeptide binding]; other site 381754006930 putative GSH binding site (G-site) [chemical binding]; other site 381754006931 putative dimer interface [polypeptide binding]; other site 381754006932 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 381754006933 putative N-terminal domain interface [polypeptide binding]; other site 381754006934 putative dimer interface [polypeptide binding]; other site 381754006935 putative substrate binding pocket (H-site) [chemical binding]; other site 381754006936 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 381754006937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754006938 Walker A/P-loop; other site 381754006939 ATP binding site [chemical binding]; other site 381754006940 Q-loop/lid; other site 381754006941 ABC transporter signature motif; other site 381754006942 Walker B; other site 381754006943 D-loop; other site 381754006944 H-loop/switch region; other site 381754006945 inner membrane transport permease; Provisional; Region: PRK15066 381754006946 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381754006947 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 381754006948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754006949 dimerization interface [polypeptide binding]; other site 381754006950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754006951 dimer interface [polypeptide binding]; other site 381754006952 phosphorylation site [posttranslational modification] 381754006953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754006954 ATP binding site [chemical binding]; other site 381754006955 Mg2+ binding site [ion binding]; other site 381754006956 G-X-G motif; other site 381754006957 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 381754006958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754006959 active site 381754006960 phosphorylation site [posttranslational modification] 381754006961 intermolecular recognition site; other site 381754006962 dimerization interface [polypeptide binding]; other site 381754006963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754006964 DNA binding site [nucleotide binding] 381754006965 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 381754006966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 381754006967 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 381754006968 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 381754006969 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 381754006970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754006971 Zn2+ binding site [ion binding]; other site 381754006972 Mg2+ binding site [ion binding]; other site 381754006973 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 381754006974 transcriptional regulator protein; Region: phnR; TIGR03337 381754006975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754006976 DNA-binding site [nucleotide binding]; DNA binding site 381754006977 UTRA domain; Region: UTRA; pfam07702 381754006978 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 381754006979 active site 381754006980 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 381754006981 PilZ domain; Region: PilZ; pfam07238 381754006982 Response regulator receiver domain; Region: Response_reg; pfam00072 381754006983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754006984 active site 381754006985 phosphorylation site [posttranslational modification] 381754006986 intermolecular recognition site; other site 381754006987 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 381754006988 dimerization interface [polypeptide binding]; other site 381754006989 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 381754006990 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 381754006991 anti sigma factor interaction site; other site 381754006992 regulatory phosphorylation site [posttranslational modification]; other site 381754006993 transaldolase-like protein; Provisional; Region: PTZ00411 381754006994 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 381754006995 active site 381754006996 dimer interface [polypeptide binding]; other site 381754006997 catalytic residue [active] 381754006998 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 381754006999 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 381754007000 FMN binding site [chemical binding]; other site 381754007001 active site 381754007002 catalytic residues [active] 381754007003 substrate binding site [chemical binding]; other site 381754007004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754007005 active site 381754007006 DNA binding site [nucleotide binding] 381754007007 Int/Topo IB signature motif; other site 381754007008 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 381754007009 Phage minor tail protein L; Region: Phage_tail_L; cl01908 381754007010 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 381754007011 substrate interaction site [chemical binding]; other site 381754007012 TIR domain; Region: TIR_2; pfam13676 381754007013 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 381754007014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754007015 AAA domain; Region: AAA_23; pfam13476 381754007016 Walker A/P-loop; other site 381754007017 ATP binding site [chemical binding]; other site 381754007018 RecT family; Region: RecT; cl04285 381754007019 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 381754007020 carbon storage regulator; Provisional; Region: PRK01712 381754007021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381754007022 Transposase; Region: HTH_Tnp_1; pfam01527 381754007023 putative transposase OrfB; Reviewed; Region: PHA02517 381754007024 HTH-like domain; Region: HTH_21; pfam13276 381754007025 Integrase core domain; Region: rve; pfam00665 381754007026 Integrase core domain; Region: rve_3; pfam13683 381754007027 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 381754007028 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 381754007029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754007030 non-specific DNA binding site [nucleotide binding]; other site 381754007031 salt bridge; other site 381754007032 sequence-specific DNA binding site [nucleotide binding]; other site 381754007033 Predicted transcriptional regulator [Transcription]; Region: COG2932 381754007034 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 381754007035 Catalytic site [active] 381754007036 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 381754007037 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 381754007038 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 381754007039 Terminase small subunit; Region: Terminase_2; pfam03592 381754007040 Phage terminase large subunit; Region: Terminase_3; cl12054 381754007041 Terminase-like family; Region: Terminase_6; pfam03237 381754007042 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 381754007043 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 381754007044 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 381754007045 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 381754007046 Phage tail protein; Region: Phage_tail_3; pfam08813 381754007047 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 381754007048 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 381754007049 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 381754007050 Phage-related minor tail protein [Function unknown]; Region: COG5281 381754007051 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 381754007052 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 381754007053 Phage minor tail protein; Region: Phage_min_tail; pfam05939 381754007054 Phage-related protein [Function unknown]; Region: gp18; COG4672 381754007055 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 381754007056 MPN+ (JAMM) motif; other site 381754007057 Zinc-binding site [ion binding]; other site 381754007058 NlpC/P60 family; Region: NLPC_P60; cl17555 381754007059 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 381754007060 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 381754007061 ORF6C domain; Region: ORF6C; pfam10552 381754007062 Phage-related protein, tail component [Function unknown]; Region: COG4723 381754007063 Phage-related protein, tail component [Function unknown]; Region: COG4733 381754007064 Putative phage tail protein; Region: Phage-tail_3; pfam13550 381754007065 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 381754007066 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 381754007067 Predicted chitinase [General function prediction only]; Region: COG3179 381754007068 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 381754007069 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 381754007070 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754007071 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754007072 dimer interface [polypeptide binding]; other site 381754007073 putative CheW interface [polypeptide binding]; other site 381754007074 glutamate carboxypeptidase; Reviewed; Region: PRK06133 381754007075 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 381754007076 metal binding site [ion binding]; metal-binding site 381754007077 dimer interface [polypeptide binding]; other site 381754007078 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582 381754007079 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 381754007080 active site 381754007081 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 381754007082 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754007083 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754007084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754007085 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 381754007086 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754007087 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 381754007088 NAD(P) binding site [chemical binding]; other site 381754007089 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 381754007090 active site 381754007091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754007092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754007093 non-specific DNA binding site [nucleotide binding]; other site 381754007094 salt bridge; other site 381754007095 sequence-specific DNA binding site [nucleotide binding]; other site 381754007096 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 381754007097 putative active site [active] 381754007098 TPR repeat; Region: TPR_11; pfam13414 381754007099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754007100 binding surface 381754007101 TPR motif; other site 381754007102 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 381754007103 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754007104 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754007105 Alginate lyase; Region: Alginate_lyase2; pfam08787 381754007106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 381754007107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754007108 Coenzyme A binding pocket [chemical binding]; other site 381754007109 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 381754007110 GAF domain; Region: GAF; pfam01590 381754007111 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754007112 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754007113 metal binding site [ion binding]; metal-binding site 381754007114 active site 381754007115 I-site; other site 381754007116 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 381754007117 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 381754007118 nudix motif; other site 381754007119 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 381754007120 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754007121 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 381754007122 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 381754007123 outer membrane porin, OprD family; Region: OprD; pfam03573 381754007124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754007125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754007127 dimerization interface [polypeptide binding]; other site 381754007128 Predicted membrane protein [Function unknown]; Region: COG4125 381754007129 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 381754007130 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 381754007131 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 381754007132 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 381754007133 secondary substrate binding site; other site 381754007134 primary substrate binding site; other site 381754007135 inhibition loop; other site 381754007136 dimerization interface [polypeptide binding]; other site 381754007137 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 381754007138 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 381754007139 Predicted membrane protein [Function unknown]; Region: COG1238 381754007140 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 381754007141 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 381754007142 Staphylococcal nuclease homologues; Region: SNc; smart00318 381754007143 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 381754007144 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 381754007145 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 381754007146 active site 381754007147 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 381754007148 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754007149 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 381754007150 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 381754007151 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 381754007152 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 381754007153 active site 381754007154 dimer interface [polypeptide binding]; other site 381754007155 motif 1; other site 381754007156 motif 2; other site 381754007157 motif 3; other site 381754007158 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 381754007159 anticodon binding site; other site 381754007160 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 381754007161 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 381754007162 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 381754007163 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 381754007164 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 381754007165 23S rRNA binding site [nucleotide binding]; other site 381754007166 L21 binding site [polypeptide binding]; other site 381754007167 L13 binding site [polypeptide binding]; other site 381754007168 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 381754007169 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 381754007170 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 381754007171 dimer interface [polypeptide binding]; other site 381754007172 motif 1; other site 381754007173 active site 381754007174 motif 2; other site 381754007175 motif 3; other site 381754007176 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 381754007177 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 381754007178 putative tRNA-binding site [nucleotide binding]; other site 381754007179 B3/4 domain; Region: B3_4; pfam03483 381754007180 tRNA synthetase B5 domain; Region: B5; smart00874 381754007181 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 381754007182 dimer interface [polypeptide binding]; other site 381754007183 motif 1; other site 381754007184 motif 3; other site 381754007185 motif 2; other site 381754007186 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 381754007187 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 381754007188 IHF dimer interface [polypeptide binding]; other site 381754007189 IHF - DNA interface [nucleotide binding]; other site 381754007190 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 381754007191 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 381754007192 DNA binding residues [nucleotide binding] 381754007193 Transposase; Region: HTH_Tnp_1; pfam01527 381754007194 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 381754007195 Mg2+ binding site [ion binding]; other site 381754007196 G-X-G motif; other site 381754007197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754007198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 381754007199 dimer interface [polypeptide binding]; other site 381754007200 phosphorylation site [posttranslational modification] 381754007201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754007202 ATP binding site [chemical binding]; other site 381754007203 Mg2+ binding site [ion binding]; other site 381754007204 G-X-G motif; other site 381754007205 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 381754007206 additional DNA contacts [nucleotide binding]; other site 381754007207 mismatch recognition site; other site 381754007208 active site 381754007209 zinc binding site [ion binding]; other site 381754007210 DNA intercalation site [nucleotide binding]; other site 381754007211 AAA-like domain; Region: AAA_10; pfam12846 381754007212 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 381754007213 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 381754007214 cofactor binding site; other site 381754007215 DNA binding site [nucleotide binding] 381754007216 substrate interaction site [chemical binding]; other site 381754007217 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 381754007218 putative transposase OrfB; Reviewed; Region: PHA02517 381754007219 HTH-like domain; Region: HTH_21; pfam13276 381754007220 Integrase core domain; Region: rve; pfam00665 381754007221 Integrase core domain; Region: rve_3; pfam13683 381754007222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381754007223 Transposase; Region: HTH_Tnp_1; pfam01527 381754007224 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 381754007225 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 381754007226 active site 381754007227 ATP binding site [chemical binding]; other site 381754007228 substrate binding site [chemical binding]; other site 381754007229 activation loop (A-loop); other site 381754007230 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 381754007231 AAA domain; Region: AAA_11; pfam13086 381754007232 Part of AAA domain; Region: AAA_19; pfam13245 381754007233 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 381754007234 AAA domain; Region: AAA_12; pfam13087 381754007235 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 381754007236 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 381754007237 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 381754007238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754007239 Walker A motif; other site 381754007240 ATP binding site [chemical binding]; other site 381754007241 Walker B motif; other site 381754007242 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 381754007243 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 381754007244 active site 381754007245 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 381754007246 GAF domain; Region: GAF; pfam01590 381754007247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754007248 Walker A motif; other site 381754007249 ATP binding site [chemical binding]; other site 381754007250 Walker B motif; other site 381754007251 arginine finger; other site 381754007252 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 381754007253 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 381754007254 heme-binding site [chemical binding]; other site 381754007255 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 381754007256 FAD binding pocket [chemical binding]; other site 381754007257 FAD binding motif [chemical binding]; other site 381754007258 phosphate binding motif [ion binding]; other site 381754007259 beta-alpha-beta structure motif; other site 381754007260 NAD binding pocket [chemical binding]; other site 381754007261 Heme binding pocket [chemical binding]; other site 381754007262 NnrS protein; Region: NnrS; pfam05940 381754007263 hypothetical protein; Provisional; Region: PRK10318 381754007264 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 381754007265 Predicted membrane protein [Function unknown]; Region: COG3212 381754007266 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 381754007267 Predicted membrane protein [Function unknown]; Region: COG3212 381754007268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754007269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754007270 active site 381754007271 phosphorylation site [posttranslational modification] 381754007272 intermolecular recognition site; other site 381754007273 dimerization interface [polypeptide binding]; other site 381754007274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754007275 DNA binding site [nucleotide binding] 381754007276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754007277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754007278 ATP binding site [chemical binding]; other site 381754007279 Mg2+ binding site [ion binding]; other site 381754007280 G-X-G motif; other site 381754007281 Cache domain; Region: Cache_1; pfam02743 381754007282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754007283 dimerization interface [polypeptide binding]; other site 381754007284 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754007285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754007286 dimer interface [polypeptide binding]; other site 381754007287 putative CheW interface [polypeptide binding]; other site 381754007288 Predicted permease [General function prediction only]; Region: COG2056 381754007289 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 381754007290 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 381754007291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754007292 dimerization interface [polypeptide binding]; other site 381754007293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754007294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754007295 dimer interface [polypeptide binding]; other site 381754007296 putative CheW interface [polypeptide binding]; other site 381754007297 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 381754007298 Domain of unknown function DUF20; Region: UPF0118; pfam01594 381754007299 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 381754007300 putative metal binding residues [ion binding]; other site 381754007301 signature motif; other site 381754007302 dimer interface [polypeptide binding]; other site 381754007303 active site 381754007304 polyP binding site; other site 381754007305 substrate binding site [chemical binding]; other site 381754007306 acceptor-phosphate pocket; other site 381754007307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 381754007308 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 381754007309 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 381754007310 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754007311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754007312 active site 381754007313 phosphorylation site [posttranslational modification] 381754007314 intermolecular recognition site; other site 381754007315 dimerization interface [polypeptide binding]; other site 381754007316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754007317 Walker A motif; other site 381754007318 ATP binding site [chemical binding]; other site 381754007319 Walker B motif; other site 381754007320 arginine finger; other site 381754007321 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754007322 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754007323 dimerization interface [polypeptide binding]; other site 381754007324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754007325 dimer interface [polypeptide binding]; other site 381754007326 phosphorylation site [posttranslational modification] 381754007327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754007328 ATP binding site [chemical binding]; other site 381754007329 Mg2+ binding site [ion binding]; other site 381754007330 G-X-G motif; other site 381754007331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754007332 S-adenosylmethionine binding site [chemical binding]; other site 381754007333 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 381754007334 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 381754007335 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 381754007336 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 381754007337 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 381754007338 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 381754007339 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 381754007340 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 381754007341 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 381754007342 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 381754007343 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 381754007344 4Fe-4S binding domain; Region: Fer4; pfam00037 381754007345 4Fe-4S binding domain; Region: Fer4; pfam00037 381754007346 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 381754007347 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 381754007348 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754007349 catalytic loop [active] 381754007350 iron binding site [ion binding]; other site 381754007351 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 381754007352 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 381754007353 [4Fe-4S] binding site [ion binding]; other site 381754007354 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 381754007355 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 381754007356 SLBB domain; Region: SLBB; pfam10531 381754007357 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 381754007358 NADH dehydrogenase subunit E; Validated; Region: PRK07539 381754007359 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 381754007360 putative dimer interface [polypeptide binding]; other site 381754007361 [2Fe-2S] cluster binding site [ion binding]; other site 381754007362 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 381754007363 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 381754007364 NADH dehydrogenase subunit D; Validated; Region: PRK06075 381754007365 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 381754007366 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 381754007367 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754007368 CoenzymeA binding site [chemical binding]; other site 381754007369 subunit interaction site [polypeptide binding]; other site 381754007370 PHB binding site; other site 381754007371 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 381754007372 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 381754007373 tetramer interface [polypeptide binding]; other site 381754007374 active site 381754007375 Mg2+/Mn2+ binding site [ion binding]; other site 381754007376 isocitrate lyase; Region: PLN02892 381754007377 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754007378 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381754007379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 381754007380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754007381 Coenzyme A binding pocket [chemical binding]; other site 381754007382 Uncharacterized conserved protein [Function unknown]; Region: COG2850 381754007383 Cupin domain; Region: Cupin_2; cl17218 381754007384 adenylosuccinate lyase; Provisional; Region: PRK09285 381754007385 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 381754007386 tetramer interface [polypeptide binding]; other site 381754007387 active site 381754007388 EamA-like transporter family; Region: EamA; pfam00892 381754007389 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 381754007390 Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915 381754007391 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 381754007392 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 381754007393 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 381754007394 nudix motif; other site 381754007395 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 381754007396 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 381754007397 isocitrate dehydrogenase; Validated; Region: PRK07362 381754007398 isocitrate dehydrogenase; Reviewed; Region: PRK07006 381754007399 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 381754007400 DNA-binding site [nucleotide binding]; DNA binding site 381754007401 RNA-binding motif; other site 381754007402 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 381754007403 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 381754007404 Clp amino terminal domain; Region: Clp_N; pfam02861 381754007405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754007406 Walker A motif; other site 381754007407 ATP binding site [chemical binding]; other site 381754007408 Walker B motif; other site 381754007409 arginine finger; other site 381754007410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754007411 Walker A motif; other site 381754007412 ATP binding site [chemical binding]; other site 381754007413 Walker B motif; other site 381754007414 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 381754007415 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 381754007416 rRNA binding site [nucleotide binding]; other site 381754007417 predicted 30S ribosome binding site; other site 381754007418 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 381754007419 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 381754007420 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 381754007421 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 381754007422 thioredoxin reductase; Provisional; Region: PRK10262 381754007423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754007424 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754007425 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 381754007426 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 381754007427 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 381754007428 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 381754007429 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 381754007430 recombination factor protein RarA; Reviewed; Region: PRK13342 381754007431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754007432 Walker A motif; other site 381754007433 ATP binding site [chemical binding]; other site 381754007434 Walker B motif; other site 381754007435 arginine finger; other site 381754007436 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 381754007437 seryl-tRNA synthetase; Provisional; Region: PRK05431 381754007438 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 381754007439 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 381754007440 dimer interface [polypeptide binding]; other site 381754007441 active site 381754007442 motif 1; other site 381754007443 motif 2; other site 381754007444 motif 3; other site 381754007445 siroheme synthase; Provisional; Region: cysG; PRK10637 381754007446 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 381754007447 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 381754007448 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 381754007449 active site 381754007450 SAM binding site [chemical binding]; other site 381754007451 homodimer interface [polypeptide binding]; other site 381754007452 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 381754007453 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 381754007454 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 381754007455 putative dimer interface [polypeptide binding]; other site 381754007456 N-terminal domain interface [polypeptide binding]; other site 381754007457 putative substrate binding pocket (H-site) [chemical binding]; other site 381754007458 hypothetical protein; Validated; Region: PRK09071 381754007459 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 381754007460 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 381754007461 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 381754007462 DsrC like protein; Region: DsrC; cl01101 381754007463 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 381754007464 sulfur relay protein TusC; Validated; Region: PRK00211 381754007465 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 381754007466 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 381754007467 YccA-like proteins; Region: YccA_like; cd10433 381754007468 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 381754007469 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754007470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754007471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754007472 DNA binding residues [nucleotide binding] 381754007473 dimerization interface [polypeptide binding]; other site 381754007474 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754007475 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754007476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754007477 hypothetical protein; Provisional; Region: PRK06753 381754007478 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 381754007479 response regulator; Provisional; Region: PRK09483 381754007480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754007481 active site 381754007482 phosphorylation site [posttranslational modification] 381754007483 intermolecular recognition site; other site 381754007484 dimerization interface [polypeptide binding]; other site 381754007485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754007486 DNA binding residues [nucleotide binding] 381754007487 dimerization interface [polypeptide binding]; other site 381754007488 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 381754007489 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 381754007490 GIY-YIG motif/motif A; other site 381754007491 active site 381754007492 catalytic site [active] 381754007493 putative DNA binding site [nucleotide binding]; other site 381754007494 metal binding site [ion binding]; metal-binding site 381754007495 UvrB/uvrC motif; Region: UVR; pfam02151 381754007496 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 381754007497 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 381754007498 DNA binding site [nucleotide binding] 381754007499 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 381754007500 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 381754007501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754007502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754007503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754007505 dimerization interface [polypeptide binding]; other site 381754007506 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 381754007507 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 381754007508 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 381754007509 catalytic residues [active] 381754007510 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 381754007511 putative kissing complex interaction region; other site 381754007512 putative RNA binding sites [nucleotide binding]; other site 381754007513 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 381754007514 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 381754007515 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 381754007516 Uncharacterized conserved protein [Function unknown]; Region: COG1262 381754007517 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 381754007518 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 381754007519 Sulfatase; Region: Sulfatase; pfam00884 381754007520 Sulfatase; Region: Sulfatase; cl17466 381754007521 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 381754007522 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 381754007523 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 381754007524 beta-galactosidase; Region: BGL; TIGR03356 381754007525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754007526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754007527 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 381754007528 Tryptophan 2,3-dioxygenase (vermilion) [Amino acid transport and metabolism]; Region: TDO2; COG3483 381754007529 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 381754007530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754007531 Coenzyme A binding pocket [chemical binding]; other site 381754007532 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754007533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754007534 putative DNA binding site [nucleotide binding]; other site 381754007535 putative Zn2+ binding site [ion binding]; other site 381754007536 AsnC family; Region: AsnC_trans_reg; pfam01037 381754007537 EamA-like transporter family; Region: EamA; pfam00892 381754007538 EamA-like transporter family; Region: EamA; pfam00892 381754007539 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 381754007540 dimer interface [polypeptide binding]; other site 381754007541 FMN binding site [chemical binding]; other site 381754007542 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 381754007543 Fatty acid desaturase; Region: FA_desaturase; pfam00487 381754007544 Di-iron ligands [ion binding]; other site 381754007545 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 381754007546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754007547 dimerization interface [polypeptide binding]; other site 381754007548 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754007549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754007550 dimer interface [polypeptide binding]; other site 381754007551 putative CheW interface [polypeptide binding]; other site 381754007552 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 381754007553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754007554 active site 381754007555 phosphorylation site [posttranslational modification] 381754007556 intermolecular recognition site; other site 381754007557 dimerization interface [polypeptide binding]; other site 381754007558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754007559 Zn2+ binding site [ion binding]; other site 381754007560 Mg2+ binding site [ion binding]; other site 381754007561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 381754007562 dimer interface [polypeptide binding]; other site 381754007563 phosphorylation site [posttranslational modification] 381754007564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754007565 ATP binding site [chemical binding]; other site 381754007566 Mg2+ binding site [ion binding]; other site 381754007567 G-X-G motif; other site 381754007568 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754007569 active site 381754007570 DNA binding site [nucleotide binding] 381754007571 Int/Topo IB signature motif; other site 381754007572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754007573 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 381754007574 tetratricopeptide repeat protein; Provisional; Region: PRK11788 381754007575 Protein of unknown function (DUF550); Region: DUF550; pfam04447 381754007576 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 381754007577 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 381754007578 GAF domain; Region: GAF; pfam01590 381754007579 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 381754007580 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754007581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754007582 metal binding site [ion binding]; metal-binding site 381754007583 active site 381754007584 I-site; other site 381754007585 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754007586 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 381754007587 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 381754007588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754007589 S-adenosylmethionine binding site [chemical binding]; other site 381754007590 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 381754007591 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 381754007592 Sulfate transporter family; Region: Sulfate_transp; pfam00916 381754007593 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 381754007594 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 381754007595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754007596 dimerization interface [polypeptide binding]; other site 381754007597 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754007598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754007599 dimer interface [polypeptide binding]; other site 381754007600 putative CheW interface [polypeptide binding]; other site 381754007601 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 381754007602 MgtC family; Region: MgtC; pfam02308 381754007603 AMP-binding domain protein; Validated; Region: PRK08315 381754007604 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754007605 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 381754007606 acyl-activating enzyme (AAE) consensus motif; other site 381754007607 putative AMP binding site [chemical binding]; other site 381754007608 putative active site [active] 381754007609 putative CoA binding site [chemical binding]; other site 381754007610 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754007611 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754007612 SurA N-terminal domain; Region: SurA_N; pfam09312 381754007613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754007614 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 381754007615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754007616 acyl-activating enzyme (AAE) consensus motif; other site 381754007617 AMP binding site [chemical binding]; other site 381754007618 active site 381754007619 CoA binding site [chemical binding]; other site 381754007620 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 381754007621 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 381754007622 NAD binding site [chemical binding]; other site 381754007623 homodimer interface [polypeptide binding]; other site 381754007624 homotetramer interface [polypeptide binding]; other site 381754007625 active site 381754007626 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 381754007627 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754007628 dimer interface [polypeptide binding]; other site 381754007629 active site 381754007630 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754007631 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754007632 active site 381754007633 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 381754007634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007635 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 381754007636 substrate binding pocket [chemical binding]; other site 381754007637 dimerization interface [polypeptide binding]; other site 381754007638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754007639 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 381754007640 FAD binding site [chemical binding]; other site 381754007641 substrate binding site [chemical binding]; other site 381754007642 catalytic base [active] 381754007643 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 381754007644 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 381754007645 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754007646 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754007647 ligand binding site [chemical binding]; other site 381754007648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007649 LysR family transcriptional regulator; Provisional; Region: PRK14997 381754007650 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754007651 putative effector binding pocket; other site 381754007652 dimerization interface [polypeptide binding]; other site 381754007653 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 381754007654 dimer interface [polypeptide binding]; other site 381754007655 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754007656 metal binding site [ion binding]; metal-binding site 381754007657 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 381754007658 putative catalytic site [active] 381754007659 putative phosphate binding site [ion binding]; other site 381754007660 active site 381754007661 metal binding site A [ion binding]; metal-binding site 381754007662 DNA binding site [nucleotide binding] 381754007663 putative AP binding site [nucleotide binding]; other site 381754007664 putative metal binding site B [ion binding]; other site 381754007665 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 381754007666 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 381754007667 Coenzyme A binding pocket [chemical binding]; other site 381754007668 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 381754007669 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381754007670 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381754007671 Surface antigen; Region: Bac_surface_Ag; pfam01103 381754007672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 381754007673 Family of unknown function (DUF490); Region: DUF490; pfam04357 381754007674 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 381754007675 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 381754007676 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754007677 Putative methyltransferase; Region: Methyltransf_20; pfam12147 381754007678 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 381754007679 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 381754007680 active site 381754007681 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 381754007682 active site 381754007683 catalytic residues [active] 381754007684 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 381754007685 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 381754007686 putative acyl-acceptor binding pocket; other site 381754007687 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 381754007688 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 381754007689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754007690 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 381754007691 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 381754007692 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 381754007693 dimer interface [polypeptide binding]; other site 381754007694 catalytic triad [active] 381754007695 peroxidatic and resolving cysteines [active] 381754007696 putative aminotransferase; Provisional; Region: PRK09105 381754007697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754007698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754007699 homodimer interface [polypeptide binding]; other site 381754007700 catalytic residue [active] 381754007701 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 381754007702 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 381754007703 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754007704 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754007705 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754007706 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 381754007707 Protein export membrane protein; Region: SecD_SecF; cl14618 381754007708 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 381754007709 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 381754007710 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 381754007711 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 381754007712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754007713 dimerization interface [polypeptide binding]; other site 381754007714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754007715 dimer interface [polypeptide binding]; other site 381754007716 phosphorylation site [posttranslational modification] 381754007717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754007718 ATP binding site [chemical binding]; other site 381754007719 Mg2+ binding site [ion binding]; other site 381754007720 G-X-G motif; other site 381754007721 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 381754007722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754007723 active site 381754007724 phosphorylation site [posttranslational modification] 381754007725 intermolecular recognition site; other site 381754007726 dimerization interface [polypeptide binding]; other site 381754007727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754007728 DNA binding site [nucleotide binding] 381754007729 Outer membrane efflux protein; Region: OEP; pfam02321 381754007730 Outer membrane efflux protein; Region: OEP; pfam02321 381754007731 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754007732 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 381754007733 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754007734 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 381754007735 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754007736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754007737 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754007738 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 381754007739 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 381754007740 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 381754007741 putative alpha subunit interface [polypeptide binding]; other site 381754007742 putative active site [active] 381754007743 putative substrate binding site [chemical binding]; other site 381754007744 Fe binding site [ion binding]; other site 381754007745 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 381754007746 inter-subunit interface; other site 381754007747 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 381754007748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754007749 catalytic loop [active] 381754007750 iron binding site [ion binding]; other site 381754007751 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 381754007752 FAD binding pocket [chemical binding]; other site 381754007753 FAD binding motif [chemical binding]; other site 381754007754 phosphate binding motif [ion binding]; other site 381754007755 beta-alpha-beta structure motif; other site 381754007756 NAD binding pocket [chemical binding]; other site 381754007757 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 381754007758 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 381754007759 putative NAD(P) binding site [chemical binding]; other site 381754007760 active site 381754007761 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 381754007762 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754007763 catalytic loop [active] 381754007764 iron binding site [ion binding]; other site 381754007765 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 381754007766 FAD binding pocket [chemical binding]; other site 381754007767 FAD binding motif [chemical binding]; other site 381754007768 phosphate binding motif [ion binding]; other site 381754007769 beta-alpha-beta structure motif; other site 381754007770 NAD binding pocket [chemical binding]; other site 381754007771 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 381754007772 inter-subunit interface; other site 381754007773 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 381754007774 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 381754007775 [2Fe-2S] cluster binding site [ion binding]; other site 381754007776 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 381754007777 putative alpha subunit interface [polypeptide binding]; other site 381754007778 putative active site [active] 381754007779 putative substrate binding site [chemical binding]; other site 381754007780 Fe binding site [ion binding]; other site 381754007781 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754007782 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 381754007783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754007785 dimerization interface [polypeptide binding]; other site 381754007786 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 381754007787 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 381754007788 octamer interface [polypeptide binding]; other site 381754007789 active site 381754007790 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 381754007791 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 381754007792 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 381754007793 active site 381754007794 outer membrane porin, OprD family; Region: OprD; pfam03573 381754007795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4859 381754007796 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 381754007797 Leucine rich repeat; Region: LRR_8; pfam13855 381754007798 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 381754007799 active site 381754007800 ATP binding site [chemical binding]; other site 381754007801 substrate binding site [chemical binding]; other site 381754007802 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 381754007803 substrate binding site [chemical binding]; other site 381754007804 activation loop (A-loop); other site 381754007805 activation loop (A-loop); other site 381754007806 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 381754007807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754007808 putative substrate translocation pore; other site 381754007809 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 381754007810 nucleoside/Zn binding site; other site 381754007811 dimer interface [polypeptide binding]; other site 381754007812 catalytic motif [active] 381754007813 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 381754007814 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 381754007815 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 381754007816 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 381754007817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754007818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754007820 dimerization interface [polypeptide binding]; other site 381754007821 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 381754007822 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 381754007823 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754007824 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754007825 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754007826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754007827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007828 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 381754007829 putative substrate binding pocket [chemical binding]; other site 381754007830 putative dimerization interface [polypeptide binding]; other site 381754007831 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 381754007832 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 381754007833 putative NAD(P) binding site [chemical binding]; other site 381754007834 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 381754007835 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754007836 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754007837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754007838 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754007839 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754007840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754007841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754007842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754007843 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 381754007844 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 381754007845 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 381754007846 Cytochrome c553 [Energy production and conversion]; Region: COG2863 381754007847 Cytochrome c; Region: Cytochrom_C; cl11414 381754007848 Cytochrome c [Energy production and conversion]; Region: COG3258 381754007849 Cytochrome c; Region: Cytochrom_C; cl11414 381754007850 Cytochrome c; Region: Cytochrom_C; pfam00034 381754007851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754007852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754007853 dimer interface [polypeptide binding]; other site 381754007854 phosphorylation site [posttranslational modification] 381754007855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754007856 ATP binding site [chemical binding]; other site 381754007857 G-X-G motif; other site 381754007858 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 381754007859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754007860 active site 381754007861 phosphorylation site [posttranslational modification] 381754007862 intermolecular recognition site; other site 381754007863 dimerization interface [polypeptide binding]; other site 381754007864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754007865 DNA binding site [nucleotide binding] 381754007866 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 381754007867 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 381754007868 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 381754007869 DsbD alpha interface [polypeptide binding]; other site 381754007870 catalytic residues [active] 381754007871 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 381754007872 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 381754007873 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 381754007874 catalytic residues [active] 381754007875 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 381754007876 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 381754007877 dimerization domain [polypeptide binding]; other site 381754007878 dimer interface [polypeptide binding]; other site 381754007879 catalytic residues [active] 381754007880 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 381754007881 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 381754007882 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 381754007883 Cytochrome P450; Region: p450; cl12078 381754007884 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 381754007885 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 381754007886 maleylacetoacetate isomerase; Region: maiA; TIGR01262 381754007887 C-terminal domain interface [polypeptide binding]; other site 381754007888 GSH binding site (G-site) [chemical binding]; other site 381754007889 putative dimer interface [polypeptide binding]; other site 381754007890 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 381754007891 dimer interface [polypeptide binding]; other site 381754007892 N-terminal domain interface [polypeptide binding]; other site 381754007893 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 381754007894 benzoate transport; Region: 2A0115; TIGR00895 381754007895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754007896 putative substrate translocation pore; other site 381754007897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754007898 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 381754007899 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 381754007900 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 381754007901 Cupin domain; Region: Cupin_2; pfam07883 381754007902 Cupin domain; Region: Cupin_2; cl17218 381754007903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007904 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 381754007905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754007906 dimerization interface [polypeptide binding]; other site 381754007907 RNA polymerase sigma factor; Provisional; Region: PRK12528 381754007908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754007909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754007910 DNA binding residues [nucleotide binding] 381754007911 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754007912 FecR protein; Region: FecR; pfam04773 381754007913 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754007914 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 381754007915 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754007916 N-terminal plug; other site 381754007917 ligand-binding site [chemical binding]; other site 381754007918 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 381754007919 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 381754007920 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 381754007921 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 381754007922 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 381754007923 haemagglutination activity domain; Region: Haemagg_act; pfam05860 381754007924 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 381754007925 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 381754007926 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 381754007927 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 381754007928 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 381754007929 threonine synthase; Validated; Region: PRK06260 381754007930 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 381754007931 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 381754007932 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 381754007933 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 381754007934 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 381754007935 ParB-like nuclease domain; Region: ParB; smart00470 381754007936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 381754007937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754007938 Coenzyme A binding pocket [chemical binding]; other site 381754007939 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754007940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754007941 S-adenosylmethionine binding site [chemical binding]; other site 381754007942 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 381754007943 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 381754007944 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 381754007945 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 381754007946 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 381754007947 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 381754007948 putative aromatic amino acid binding site; other site 381754007949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754007950 Walker A motif; other site 381754007951 ATP binding site [chemical binding]; other site 381754007952 Walker B motif; other site 381754007953 arginine finger; other site 381754007954 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 381754007955 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 381754007956 active site 381754007957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754007958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007959 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754007960 dimerization interface [polypeptide binding]; other site 381754007961 putative effector binding pocket; other site 381754007962 glycine cleavage system protein H; Provisional; Region: PRK13380 381754007963 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 381754007964 lipoyl attachment site [posttranslational modification]; other site 381754007965 glycine dehydrogenase; Provisional; Region: PRK05367 381754007966 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 381754007967 tetramer interface [polypeptide binding]; other site 381754007968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754007969 catalytic residue [active] 381754007970 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 381754007971 tetramer interface [polypeptide binding]; other site 381754007972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754007973 catalytic residue [active] 381754007974 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 381754007975 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 381754007976 dimer interface [polypeptide binding]; other site 381754007977 active site 381754007978 glycine-pyridoxal phosphate binding site [chemical binding]; other site 381754007979 folate binding site [chemical binding]; other site 381754007980 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 381754007981 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 381754007982 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 381754007983 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 381754007984 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 381754007985 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 381754007986 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 381754007987 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 381754007988 putative active site [active] 381754007989 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 381754007990 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 381754007991 HflC protein; Region: hflC; TIGR01932 381754007992 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 381754007993 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 381754007994 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 381754007995 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 381754007996 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381754007997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754007998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754007999 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754008000 putative effector binding pocket; other site 381754008001 dimerization interface [polypeptide binding]; other site 381754008002 Predicted membrane protein [Function unknown]; Region: COG1289 381754008003 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 381754008004 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 381754008005 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754008006 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754008007 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 381754008008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 381754008009 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 381754008010 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 381754008011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754008012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754008013 DNA binding residues [nucleotide binding] 381754008014 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 381754008015 peptide synthase; Validated; Region: PRK05691 381754008016 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 381754008017 acyl-activating enzyme (AAE) consensus motif; other site 381754008018 active site 381754008019 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008020 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 381754008021 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008022 acyl-activating enzyme (AAE) consensus motif; other site 381754008023 AMP binding site [chemical binding]; other site 381754008024 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008025 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 381754008026 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008027 acyl-activating enzyme (AAE) consensus motif; other site 381754008028 AMP binding site [chemical binding]; other site 381754008029 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008030 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 381754008031 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 381754008032 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008033 acyl-activating enzyme (AAE) consensus motif; other site 381754008034 AMP binding site [chemical binding]; other site 381754008035 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754008037 S-adenosylmethionine binding site [chemical binding]; other site 381754008038 Prophage antirepressor [Transcription]; Region: COG3617 381754008039 BRO family, N-terminal domain; Region: Bro-N; cl10591 381754008040 HTH-like domain; Region: HTH_21; pfam13276 381754008041 Integrase core domain; Region: rve; pfam00665 381754008042 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381754008043 Integrase core domain; Region: rve_3; pfam13683 381754008044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381754008045 Transposase; Region: HTH_Tnp_1; pfam01527 381754008046 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 381754008047 outer membrane porin, OprD family; Region: OprD; pfam03573 381754008048 Isochorismatase family; Region: Isochorismatase; pfam00857 381754008049 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 381754008050 catalytic triad [active] 381754008051 dimer interface [polypeptide binding]; other site 381754008052 conserved cis-peptide bond; other site 381754008053 Pirin-related protein [General function prediction only]; Region: COG1741 381754008054 Pirin; Region: Pirin; pfam02678 381754008055 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 381754008056 LysR family transcriptional regulator; Provisional; Region: PRK14997 381754008057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008058 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 381754008059 putative effector binding pocket; other site 381754008060 putative dimerization interface [polypeptide binding]; other site 381754008061 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 381754008062 trehalase; Provisional; Region: treA; PRK13272 381754008063 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 381754008064 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 381754008065 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 381754008066 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754008067 inhibitor-cofactor binding pocket; inhibition site 381754008068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754008069 catalytic residue [active] 381754008070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 381754008071 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 381754008072 Serine hydrolase; Region: Ser_hydrolase; cl17834 381754008073 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 381754008074 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 381754008075 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 381754008076 ABC-ATPase subunit interface; other site 381754008077 dimer interface [polypeptide binding]; other site 381754008078 putative PBP binding regions; other site 381754008079 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 381754008080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754008081 Walker A/P-loop; other site 381754008082 ATP binding site [chemical binding]; other site 381754008083 Q-loop/lid; other site 381754008084 ABC transporter signature motif; other site 381754008085 Walker B; other site 381754008086 D-loop; other site 381754008087 H-loop/switch region; other site 381754008088 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 381754008089 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 381754008090 intersubunit interface [polypeptide binding]; other site 381754008091 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 381754008092 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 381754008093 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 381754008094 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 381754008095 Condensation domain; Region: Condensation; pfam00668 381754008096 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 381754008097 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 381754008098 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008099 acyl-activating enzyme (AAE) consensus motif; other site 381754008100 AMP binding site [chemical binding]; other site 381754008101 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008102 Condensation domain; Region: Condensation; pfam00668 381754008103 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 381754008104 Condensation domain; Region: Condensation; pfam00668 381754008105 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 381754008106 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008107 acyl-activating enzyme (AAE) consensus motif; other site 381754008108 AMP binding site [chemical binding]; other site 381754008109 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008110 Condensation domain; Region: Condensation; pfam00668 381754008111 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 381754008112 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 381754008113 Condensation domain; Region: Condensation; pfam00668 381754008114 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 381754008115 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008116 acyl-activating enzyme (AAE) consensus motif; other site 381754008117 AMP binding site [chemical binding]; other site 381754008118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008119 peptide synthase; Provisional; Region: PRK12467 381754008120 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 381754008121 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 381754008122 acyl-activating enzyme (AAE) consensus motif; other site 381754008123 AMP binding site [chemical binding]; other site 381754008124 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008125 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 381754008126 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008127 acyl-activating enzyme (AAE) consensus motif; other site 381754008128 AMP binding site [chemical binding]; other site 381754008129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008130 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 381754008131 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008132 acyl-activating enzyme (AAE) consensus motif; other site 381754008133 AMP binding site [chemical binding]; other site 381754008134 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008135 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 381754008136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 381754008137 acyl-activating enzyme (AAE) consensus motif; other site 381754008138 AMP binding site [chemical binding]; other site 381754008139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754008140 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 381754008141 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 381754008142 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381754008143 Secretin and TonB N terminus short domain; Region: STN; pfam07660 381754008144 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 381754008145 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754008146 N-terminal plug; other site 381754008147 ligand-binding site [chemical binding]; other site 381754008148 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 381754008149 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754008150 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 381754008151 Walker A/P-loop; other site 381754008152 ATP binding site [chemical binding]; other site 381754008153 Q-loop/lid; other site 381754008154 ABC transporter signature motif; other site 381754008155 Walker B; other site 381754008156 D-loop; other site 381754008157 H-loop/switch region; other site 381754008158 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 381754008159 catalytic site [active] 381754008160 Uncharacterized conserved protein [Function unknown]; Region: COG1262 381754008161 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 381754008162 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 381754008163 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 381754008164 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754008165 catalytic residue [active] 381754008166 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 381754008167 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 381754008168 active site 381754008169 dimer interface [polypeptide binding]; other site 381754008170 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 381754008171 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 381754008172 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 381754008173 Walker A/P-loop; other site 381754008174 ATP binding site [chemical binding]; other site 381754008175 Q-loop/lid; other site 381754008176 ABC transporter signature motif; other site 381754008177 Walker B; other site 381754008178 D-loop; other site 381754008179 H-loop/switch region; other site 381754008180 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 381754008181 FtsX-like permease family; Region: FtsX; pfam02687 381754008182 macrolide transporter subunit MacA; Provisional; Region: PRK11578 381754008183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754008184 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754008185 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754008186 FecR protein; Region: FecR; pfam04773 381754008187 RNA polymerase sigma factor; Reviewed; Region: PRK12527 381754008188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754008189 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 381754008190 DNA binding residues [nucleotide binding] 381754008191 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 381754008192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754008193 Penicillin amidase; Region: Penicil_amidase; pfam01804 381754008194 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 381754008195 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 381754008196 active site 381754008197 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 381754008198 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 381754008199 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754008200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754008202 dimerization interface [polypeptide binding]; other site 381754008203 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 381754008204 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 381754008205 phosphate binding site [ion binding]; other site 381754008206 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 381754008207 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 381754008208 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754008209 catalytic loop [active] 381754008210 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 381754008211 iron binding site [ion binding]; other site 381754008212 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 381754008213 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 381754008214 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754008215 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 381754008216 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754008217 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754008218 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 381754008219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754008220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754008221 active site 381754008222 phosphorylation site [posttranslational modification] 381754008223 intermolecular recognition site; other site 381754008224 dimerization interface [polypeptide binding]; other site 381754008225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754008226 DNA binding residues [nucleotide binding] 381754008227 dimerization interface [polypeptide binding]; other site 381754008228 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 381754008229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 381754008230 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 381754008231 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 381754008232 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 381754008233 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 381754008234 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 381754008235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754008236 Walker A motif; other site 381754008237 ATP binding site [chemical binding]; other site 381754008238 Walker B motif; other site 381754008239 arginine finger; other site 381754008240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754008241 Walker A motif; other site 381754008242 ATP binding site [chemical binding]; other site 381754008243 Walker B motif; other site 381754008244 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 381754008245 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 381754008246 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 381754008247 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 381754008248 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 381754008249 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 381754008250 Protein of unknown function (DUF877); Region: DUF877; pfam05943 381754008251 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 381754008252 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 381754008253 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 381754008254 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 381754008255 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 381754008256 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 381754008257 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 381754008258 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 381754008259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754008260 Walker A motif; other site 381754008261 ATP binding site [chemical binding]; other site 381754008262 Walker B motif; other site 381754008263 arginine finger; other site 381754008264 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 381754008265 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 381754008266 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754008267 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 381754008268 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 381754008269 active site 381754008270 dimer interface [polypeptide binding]; other site 381754008271 non-prolyl cis peptide bond; other site 381754008272 insertion regions; other site 381754008273 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 381754008274 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 381754008275 Flavin binding site [chemical binding]; other site 381754008276 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 381754008277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754008278 Walker A motif; other site 381754008279 ATP binding site [chemical binding]; other site 381754008280 Walker B motif; other site 381754008281 arginine finger; other site 381754008282 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 381754008283 Predicted ATPase [General function prediction only]; Region: COG1485 381754008284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754008285 Walker B; other site 381754008286 D-loop; other site 381754008287 H-loop/switch region; other site 381754008288 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 381754008289 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 381754008290 active site 381754008291 catalytic site [active] 381754008292 metal binding site [ion binding]; metal-binding site 381754008293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754008294 dimer interface [polypeptide binding]; other site 381754008295 conserved gate region; other site 381754008296 ABC-ATPase subunit interface; other site 381754008297 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 381754008298 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 381754008299 Walker A/P-loop; other site 381754008300 ATP binding site [chemical binding]; other site 381754008301 Q-loop/lid; other site 381754008302 ABC transporter signature motif; other site 381754008303 Walker B; other site 381754008304 D-loop; other site 381754008305 H-loop/switch region; other site 381754008306 NIL domain; Region: NIL; pfam09383 381754008307 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 381754008308 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 381754008309 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 381754008310 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 381754008311 active site 381754008312 non-prolyl cis peptide bond; other site 381754008313 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 381754008314 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754008315 active site 381754008316 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 381754008317 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754008318 active site 381754008319 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 381754008320 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 381754008321 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 381754008322 putative substrate binding site [chemical binding]; other site 381754008323 putative ATP binding site [chemical binding]; other site 381754008324 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 381754008325 N- and C-terminal domain interface [polypeptide binding]; other site 381754008326 D-xylulose kinase; Region: XylB; TIGR01312 381754008327 active site 381754008328 MgATP binding site [chemical binding]; other site 381754008329 catalytic site [active] 381754008330 metal binding site [ion binding]; metal-binding site 381754008331 xylulose binding site [chemical binding]; other site 381754008332 putative homodimer interface [polypeptide binding]; other site 381754008333 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 381754008334 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 381754008335 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 381754008336 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 381754008337 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 381754008338 Walker A/P-loop; other site 381754008339 ATP binding site [chemical binding]; other site 381754008340 Q-loop/lid; other site 381754008341 ABC transporter signature motif; other site 381754008342 Walker B; other site 381754008343 D-loop; other site 381754008344 H-loop/switch region; other site 381754008345 TOBE domain; Region: TOBE_2; pfam08402 381754008346 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381754008347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754008348 dimer interface [polypeptide binding]; other site 381754008349 conserved gate region; other site 381754008350 ABC-ATPase subunit interface; other site 381754008351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754008352 dimer interface [polypeptide binding]; other site 381754008353 conserved gate region; other site 381754008354 putative PBP binding loops; other site 381754008355 ABC-ATPase subunit interface; other site 381754008356 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 381754008357 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 381754008358 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754008359 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754008360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754008361 Cupin; Region: Cupin_6; pfam12852 381754008362 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754008363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754008364 Uncharacterized conserved protein [Function unknown]; Region: COG2128 381754008365 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 381754008366 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754008367 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754008368 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 381754008369 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 381754008370 Walker A/P-loop; other site 381754008371 ATP binding site [chemical binding]; other site 381754008372 Q-loop/lid; other site 381754008373 ABC transporter signature motif; other site 381754008374 Walker B; other site 381754008375 D-loop; other site 381754008376 H-loop/switch region; other site 381754008377 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 381754008378 NMT1-like family; Region: NMT1_2; pfam13379 381754008379 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 381754008380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754008381 dimer interface [polypeptide binding]; other site 381754008382 conserved gate region; other site 381754008383 putative PBP binding loops; other site 381754008384 ABC-ATPase subunit interface; other site 381754008385 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 381754008386 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 381754008387 active site 381754008388 non-prolyl cis peptide bond; other site 381754008389 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 381754008390 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 381754008391 Flavin binding site [chemical binding]; other site 381754008392 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 381754008393 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 381754008394 Flavin binding site [chemical binding]; other site 381754008395 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 381754008396 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 381754008397 tetrameric interface [polypeptide binding]; other site 381754008398 activator binding site; other site 381754008399 NADP binding site [chemical binding]; other site 381754008400 substrate binding site [chemical binding]; other site 381754008401 catalytic residues [active] 381754008402 GntP family permease; Region: GntP_permease; pfam02447 381754008403 fructuronate transporter; Provisional; Region: PRK10034; cl15264 381754008404 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 381754008405 AAA domain; Region: AAA_33; pfam13671 381754008406 ATP-binding site [chemical binding]; other site 381754008407 Gluconate-6-phosphate binding site [chemical binding]; other site 381754008408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 381754008409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381754008410 DNA binding site [nucleotide binding] 381754008411 domain linker motif; other site 381754008412 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 381754008413 putative ligand binding site [chemical binding]; other site 381754008414 putative dimerization interface [polypeptide binding]; other site 381754008415 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 381754008416 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754008417 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754008418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754008419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008420 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 381754008421 putative dimerization interface [polypeptide binding]; other site 381754008422 putative effector binding pocket; other site 381754008423 Beta-lactamase; Region: Beta-lactamase; cl17358 381754008424 Beta-lactamase; Region: Beta-lactamase; pfam00144 381754008425 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 381754008426 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 381754008427 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754008428 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 381754008429 putative deacylase active site [active] 381754008430 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 381754008431 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 381754008432 putative active site [active] 381754008433 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 381754008434 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 381754008435 Interdomain contacts; other site 381754008436 Cytokine receptor motif; other site 381754008437 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 381754008438 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 381754008439 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 381754008440 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 381754008441 Trp docking motif [polypeptide binding]; other site 381754008442 putative active site [active] 381754008443 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 381754008444 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754008445 N-terminal plug; other site 381754008446 ligand-binding site [chemical binding]; other site 381754008447 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 381754008448 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 381754008449 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754008450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754008451 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 381754008452 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754008453 Low molecular weight phosphatase family; Region: LMWPc; cd00115 381754008454 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 381754008455 active site 381754008456 arsenical pump membrane protein; Provisional; Region: PRK15445 381754008457 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 381754008458 transmembrane helices; other site 381754008459 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 381754008460 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754008461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754008462 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 381754008463 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 381754008464 putative NAD(P) binding site [chemical binding]; other site 381754008465 putative substrate binding site [chemical binding]; other site 381754008466 catalytic Zn binding site [ion binding]; other site 381754008467 structural Zn binding site [ion binding]; other site 381754008468 dimer interface [polypeptide binding]; other site 381754008469 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 381754008470 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 381754008471 DNA binding residues [nucleotide binding] 381754008472 dimer interface [polypeptide binding]; other site 381754008473 [2Fe-2S] cluster binding site [ion binding]; other site 381754008474 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 381754008475 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 381754008476 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 381754008477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 381754008478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754008479 Coenzyme A binding pocket [chemical binding]; other site 381754008480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754008481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754008482 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754008483 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 381754008484 active site 381754008485 putative oxyanion hole; other site 381754008486 catalytic triad [active] 381754008487 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 381754008488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754008489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754008491 dimerization interface [polypeptide binding]; other site 381754008492 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754008493 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754008494 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754008495 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 381754008496 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 381754008497 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 381754008498 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 381754008499 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 381754008500 dimerization interface [polypeptide binding]; other site 381754008501 ligand binding site [chemical binding]; other site 381754008502 NADP binding site [chemical binding]; other site 381754008503 catalytic site [active] 381754008504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754008505 D-galactonate transporter; Region: 2A0114; TIGR00893 381754008506 putative substrate translocation pore; other site 381754008507 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 381754008508 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 381754008509 substrate binding site [chemical binding]; other site 381754008510 ATP binding site [chemical binding]; other site 381754008511 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 381754008512 Transcriptional regulators [Transcription]; Region: PurR; COG1609 381754008513 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381754008514 DNA binding site [nucleotide binding] 381754008515 domain linker motif; other site 381754008516 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 381754008517 putative dimerization interface [polypeptide binding]; other site 381754008518 putative ligand binding site [chemical binding]; other site 381754008519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754008520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008521 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754008522 putative effector binding pocket; other site 381754008523 dimerization interface [polypeptide binding]; other site 381754008524 Cytochrome c553 [Energy production and conversion]; Region: COG2863 381754008525 Cytochrome c; Region: Cytochrom_C; cl11414 381754008526 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 381754008527 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 381754008528 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 381754008529 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 381754008530 substrate binding pocket [chemical binding]; other site 381754008531 active site 381754008532 iron coordination sites [ion binding]; other site 381754008533 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 381754008534 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 381754008535 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 381754008536 active site 381754008537 homodimer interface [polypeptide binding]; other site 381754008538 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 381754008539 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 381754008540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 381754008541 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 381754008542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754008543 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 381754008544 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 381754008545 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 381754008546 E3 interaction surface; other site 381754008547 lipoyl attachment site [posttranslational modification]; other site 381754008548 e3 binding domain; Region: E3_binding; pfam02817 381754008549 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 381754008550 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 381754008551 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 381754008552 alpha subunit interface [polypeptide binding]; other site 381754008553 TPP binding site [chemical binding]; other site 381754008554 heterodimer interface [polypeptide binding]; other site 381754008555 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 381754008556 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 381754008557 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 381754008558 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 381754008559 tetramer interface [polypeptide binding]; other site 381754008560 TPP-binding site [chemical binding]; other site 381754008561 heterodimer interface [polypeptide binding]; other site 381754008562 phosphorylation loop region [posttranslational modification] 381754008563 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754008564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754008565 putative DNA binding site [nucleotide binding]; other site 381754008566 putative Zn2+ binding site [ion binding]; other site 381754008567 AsnC family; Region: AsnC_trans_reg; pfam01037 381754008568 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 381754008569 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 381754008570 active site 381754008571 DNA binding site [nucleotide binding] 381754008572 Int/Topo IB signature motif; other site 381754008573 catalytic residues [active] 381754008574 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 381754008575 Acyltransferase family; Region: Acyl_transf_3; pfam01757 381754008576 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 381754008577 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 381754008578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754008579 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 381754008580 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 381754008581 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 381754008582 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 381754008583 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754008584 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 381754008585 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 381754008586 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381754008587 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 381754008588 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 381754008589 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 381754008590 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 381754008591 active site 381754008592 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 381754008593 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 381754008594 Substrate binding site; other site 381754008595 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 381754008596 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 381754008597 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 381754008598 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754008599 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754008600 catalytic residue [active] 381754008601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754008602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008603 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754008604 putative effector binding pocket; other site 381754008605 dimerization interface [polypeptide binding]; other site 381754008606 Isochorismatase family; Region: Isochorismatase; pfam00857 381754008607 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 381754008608 catalytic triad [active] 381754008609 dimer interface [polypeptide binding]; other site 381754008610 conserved cis-peptide bond; other site 381754008611 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754008612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754008613 dimer interface [polypeptide binding]; other site 381754008614 phosphorylation site [posttranslational modification] 381754008615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754008616 ATP binding site [chemical binding]; other site 381754008617 Mg2+ binding site [ion binding]; other site 381754008618 G-X-G motif; other site 381754008619 Response regulator receiver domain; Region: Response_reg; pfam00072 381754008620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754008621 active site 381754008622 phosphorylation site [posttranslational modification] 381754008623 intermolecular recognition site; other site 381754008624 dimerization interface [polypeptide binding]; other site 381754008625 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381754008626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754008627 active site 381754008628 phosphorylation site [posttranslational modification] 381754008629 intermolecular recognition site; other site 381754008630 dimerization interface [polypeptide binding]; other site 381754008631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754008632 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754008633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754008634 dimer interface [polypeptide binding]; other site 381754008635 phosphorylation site [posttranslational modification] 381754008636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754008637 ATP binding site [chemical binding]; other site 381754008638 Mg2+ binding site [ion binding]; other site 381754008639 G-X-G motif; other site 381754008640 Response regulator receiver domain; Region: Response_reg; pfam00072 381754008641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754008642 active site 381754008643 phosphorylation site [posttranslational modification] 381754008644 intermolecular recognition site; other site 381754008645 dimerization interface [polypeptide binding]; other site 381754008646 Hpt domain; Region: Hpt; pfam01627 381754008647 transcriptional regulator RcsB; Provisional; Region: PRK10840 381754008648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754008649 active site 381754008650 phosphorylation site [posttranslational modification] 381754008651 intermolecular recognition site; other site 381754008652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754008653 DNA binding residues [nucleotide binding] 381754008654 dimerization interface [polypeptide binding]; other site 381754008655 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 381754008656 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 381754008657 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 381754008658 Fimbrial protein; Region: Fimbrial; cl01416 381754008659 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 381754008660 PapC N-terminal domain; Region: PapC_N; pfam13954 381754008661 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 381754008662 PapC C-terminal domain; Region: PapC_C; pfam13953 381754008663 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 381754008664 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 381754008665 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 381754008666 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 381754008667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 381754008668 MOSC domain; Region: MOSC; pfam03473 381754008669 3-alpha domain; Region: 3-alpha; pfam03475 381754008670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754008671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008672 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 381754008673 putative substrate binding pocket [chemical binding]; other site 381754008674 putative dimerization interface [polypeptide binding]; other site 381754008675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754008676 metabolite-proton symporter; Region: 2A0106; TIGR00883 381754008677 putative substrate translocation pore; other site 381754008678 Predicted amidohydrolase [General function prediction only]; Region: COG0388 381754008679 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 381754008680 putative active site [active] 381754008681 catalytic triad [active] 381754008682 putative dimer interface [polypeptide binding]; other site 381754008683 Cytochrome c553 [Energy production and conversion]; Region: COG2863 381754008684 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754008685 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754008686 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 381754008687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754008688 DNA-binding site [nucleotide binding]; DNA binding site 381754008689 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754008690 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754008691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754008692 homodimer interface [polypeptide binding]; other site 381754008693 catalytic residue [active] 381754008694 short chain dehydrogenase; Provisional; Region: PRK06500 381754008695 classical (c) SDRs; Region: SDR_c; cd05233 381754008696 NAD(P) binding site [chemical binding]; other site 381754008697 active site 381754008698 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 381754008699 S-type Pyocin; Region: Pyocin_S; pfam06958 381754008700 Colicin D; Region: Colicin_D; pfam11429 381754008701 Integrase core domain; Region: rve; pfam00665 381754008702 Integrase core domain; Region: rve; pfam00665 381754008703 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 381754008704 Bacterial TniB protein; Region: TniB; pfam05621 381754008705 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754008706 active site 381754008707 DNA binding site [nucleotide binding] 381754008708 Int/Topo IB signature motif; other site 381754008709 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754008710 active site 381754008711 DNA binding site [nucleotide binding] 381754008712 Int/Topo IB signature motif; other site 381754008713 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 381754008714 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 381754008715 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 381754008716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754008717 ABC transporter signature motif; other site 381754008718 Walker B; other site 381754008719 D-loop; other site 381754008720 H-loop/switch region; other site 381754008721 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 381754008722 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 381754008723 DNA binding site [nucleotide binding] 381754008724 dimer interface [polypeptide binding]; other site 381754008725 active site 381754008726 Int/Topo IB signature motif; other site 381754008727 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 381754008728 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 381754008729 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 381754008730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754008731 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 381754008732 Coenzyme A binding pocket [chemical binding]; other site 381754008733 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 381754008734 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 381754008735 Transposase, Mutator family; Region: Transposase_mut; pfam00872 381754008736 MULE transposase domain; Region: MULE; pfam10551 381754008737 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 381754008738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754008739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008740 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 381754008741 putative effector binding pocket; other site 381754008742 putative dimerization interface [polypeptide binding]; other site 381754008743 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 381754008744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754008745 putative substrate translocation pore; other site 381754008746 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 381754008747 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 381754008748 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 381754008749 dimer interface [polypeptide binding]; other site 381754008750 NADP binding site [chemical binding]; other site 381754008751 catalytic residues [active] 381754008752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 381754008753 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 381754008754 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 381754008755 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 381754008756 putative active site pocket [active] 381754008757 putative metal binding site [ion binding]; other site 381754008758 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 381754008759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754008760 putative substrate translocation pore; other site 381754008761 outer membrane porin, OprD family; Region: OprD; pfam03573 381754008762 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 381754008763 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 381754008764 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 381754008765 Amidohydrolase; Region: Amidohydro_2; pfam04909 381754008766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754008767 D-galactonate transporter; Region: 2A0114; TIGR00893 381754008768 putative substrate translocation pore; other site 381754008769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 381754008770 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 381754008771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 381754008772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754008773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754008774 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754008775 dimerization interface [polypeptide binding]; other site 381754008776 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754008777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754008778 substrate binding pocket [chemical binding]; other site 381754008779 membrane-bound complex binding site; other site 381754008780 hinge residues; other site 381754008781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754008782 dimer interface [polypeptide binding]; other site 381754008783 conserved gate region; other site 381754008784 putative PBP binding loops; other site 381754008785 ABC-ATPase subunit interface; other site 381754008786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754008787 dimer interface [polypeptide binding]; other site 381754008788 conserved gate region; other site 381754008789 putative PBP binding loops; other site 381754008790 ABC-ATPase subunit interface; other site 381754008791 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 381754008792 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 381754008793 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754008794 N-terminal plug; other site 381754008795 ligand-binding site [chemical binding]; other site 381754008796 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 381754008797 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 381754008798 IucA / IucC family; Region: IucA_IucC; pfam04183 381754008799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754008800 putative substrate translocation pore; other site 381754008801 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 381754008802 IucA / IucC family; Region: IucA_IucC; pfam04183 381754008803 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 381754008804 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 381754008805 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 381754008806 dimer interface [polypeptide binding]; other site 381754008807 active site 381754008808 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381754008809 catalytic residues [active] 381754008810 substrate binding site [chemical binding]; other site 381754008811 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 381754008812 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 381754008813 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 381754008814 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754008815 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 381754008816 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 381754008817 NAD binding site [chemical binding]; other site 381754008818 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 381754008819 Prostaglandin dehydrogenases; Region: PGDH; cd05288 381754008820 NAD(P) binding site [chemical binding]; other site 381754008821 substrate binding site [chemical binding]; other site 381754008822 dimer interface [polypeptide binding]; other site 381754008823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754008824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754008825 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754008826 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381754008827 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 381754008828 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 381754008829 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754008830 catalytic loop [active] 381754008831 iron binding site [ion binding]; other site 381754008832 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 381754008833 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 381754008834 active site 381754008835 catalytic site [active] 381754008836 trehalose synthase; Region: treS_nterm; TIGR02456 381754008837 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 381754008838 active site 381754008839 catalytic site [active] 381754008840 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 381754008841 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 381754008842 putative NAD(P) binding site [chemical binding]; other site 381754008843 active site 381754008844 FOG: CBS domain [General function prediction only]; Region: COG0517 381754008845 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 381754008846 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 381754008847 General stress protein [General function prediction only]; Region: GsiB; COG3729 381754008848 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 381754008849 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 381754008850 active site 381754008851 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 381754008852 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 381754008853 Trp docking motif [polypeptide binding]; other site 381754008854 putative active site [active] 381754008855 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 381754008856 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 381754008857 NAD binding site [chemical binding]; other site 381754008858 catalytic Zn binding site [ion binding]; other site 381754008859 structural Zn binding site [ion binding]; other site 381754008860 Low affinity iron permease; Region: Iron_permease; pfam04120 381754008861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 381754008862 Predicted membrane protein [Function unknown]; Region: COG3205 381754008863 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 381754008864 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 381754008865 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 381754008866 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 381754008867 carboxylate-amine ligase; Provisional; Region: PRK13515 381754008868 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 381754008869 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 381754008870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754008871 S-adenosylmethionine binding site [chemical binding]; other site 381754008872 Yip1 domain; Region: Yip1; pfam04893 381754008873 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754008874 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 381754008875 putative active site [active] 381754008876 heme pocket [chemical binding]; other site 381754008877 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754008878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754008879 putative active site [active] 381754008880 heme pocket [chemical binding]; other site 381754008881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754008882 dimer interface [polypeptide binding]; other site 381754008883 phosphorylation site [posttranslational modification] 381754008884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754008885 ATP binding site [chemical binding]; other site 381754008886 Mg2+ binding site [ion binding]; other site 381754008887 G-X-G motif; other site 381754008888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754008889 active site 381754008890 phosphorylation site [posttranslational modification] 381754008891 intermolecular recognition site; other site 381754008892 dimerization interface [polypeptide binding]; other site 381754008893 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 381754008894 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 381754008895 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 381754008896 metal binding site [ion binding]; metal-binding site 381754008897 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 381754008898 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 381754008899 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 381754008900 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381754008901 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 381754008902 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 381754008903 glycogen synthase; Provisional; Region: glgA; PRK00654 381754008904 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 381754008905 ADP-binding pocket [chemical binding]; other site 381754008906 homodimer interface [polypeptide binding]; other site 381754008907 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 381754008908 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 381754008909 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 381754008910 catalytic site [active] 381754008911 active site 381754008912 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 381754008913 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 381754008914 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 381754008915 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 381754008916 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 381754008917 active site 381754008918 catalytic site [active] 381754008919 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 381754008920 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 381754008921 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 381754008922 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 381754008923 active site 381754008924 catalytic site [active] 381754008925 FOG: CBS domain [General function prediction only]; Region: COG0517 381754008926 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 381754008927 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 381754008928 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 381754008929 NAD binding site [chemical binding]; other site 381754008930 catalytic Zn binding site [ion binding]; other site 381754008931 structural Zn binding site [ion binding]; other site 381754008932 Protein of unknown function DUF72; Region: DUF72; pfam01904 381754008933 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 381754008934 putative catalytic site [active] 381754008935 putative metal binding site [ion binding]; other site 381754008936 putative phosphate binding site [ion binding]; other site 381754008937 cardiolipin synthase 2; Provisional; Region: PRK11263 381754008938 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 381754008939 putative active site [active] 381754008940 catalytic site [active] 381754008941 SRP19 protein; Region: SRP19; cl00617 381754008942 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 381754008943 putative active site [active] 381754008944 catalytic site [active] 381754008945 Predicted integral membrane protein [Function unknown]; Region: COG0392 381754008946 glycogen branching enzyme; Provisional; Region: PRK05402 381754008947 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 381754008948 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 381754008949 active site 381754008950 catalytic site [active] 381754008951 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 381754008952 trehalose synthase; Region: treS_nterm; TIGR02456 381754008953 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 381754008954 active site 381754008955 catalytic site [active] 381754008956 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 381754008957 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 381754008958 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 381754008959 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 381754008960 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 381754008961 active site 381754008962 homodimer interface [polypeptide binding]; other site 381754008963 catalytic site [active] 381754008964 acceptor binding site [chemical binding]; other site 381754008965 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 381754008966 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 381754008967 putative DNA binding site [nucleotide binding]; other site 381754008968 putative homodimer interface [polypeptide binding]; other site 381754008969 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 381754008970 MgtC family; Region: MgtC; pfam02308 381754008971 hydroperoxidase II; Provisional; Region: katE; PRK11249 381754008972 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 381754008973 tetramer interface [polypeptide binding]; other site 381754008974 heme binding pocket [chemical binding]; other site 381754008975 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 381754008976 domain interactions; other site 381754008977 General stress protein [General function prediction only]; Region: GsiB; COG3729 381754008978 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 381754008979 homodimer interface [polypeptide binding]; other site 381754008980 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 381754008981 active site pocket [active] 381754008982 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 381754008983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754008984 active site 381754008985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754008986 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 381754008987 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 381754008988 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 381754008989 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 381754008990 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 381754008991 active site 381754008992 DNA binding site [nucleotide binding] 381754008993 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 381754008994 DNA binding site [nucleotide binding] 381754008995 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 381754008996 nucleotide binding site [chemical binding]; other site 381754008997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 381754008998 active site 381754008999 phosphorylation site [posttranslational modification] 381754009000 intermolecular recognition site; other site 381754009001 dimerization interface [polypeptide binding]; other site 381754009002 Predicted membrane protein [Function unknown]; Region: COG2323 381754009003 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 381754009004 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 381754009005 Predicted outer membrane protein [Function unknown]; Region: COG3652 381754009006 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 381754009007 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 381754009008 Active Sites [active] 381754009009 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 381754009010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 381754009011 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 381754009012 ParB-like nuclease domain; Region: ParBc; pfam02195 381754009013 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 381754009014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009015 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 381754009016 hydrophobic ligand binding site; other site 381754009017 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 381754009018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009019 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 381754009020 substrate binding pocket [chemical binding]; other site 381754009021 dimerization interface [polypeptide binding]; other site 381754009022 SnoaL-like domain; Region: SnoaL_2; pfam12680 381754009023 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 381754009024 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 381754009025 tetramer interface [polypeptide binding]; other site 381754009026 catalytic Zn binding site [ion binding]; other site 381754009027 NADP binding site [chemical binding]; other site 381754009028 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 381754009029 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 381754009030 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 381754009031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754009032 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 381754009033 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 381754009034 DNA binding site [nucleotide binding] 381754009035 active site 381754009036 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 381754009037 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 381754009038 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 381754009039 hypothetical protein; Provisional; Region: PRK05463 381754009040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754009041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754009043 dimerization interface [polypeptide binding]; other site 381754009044 benzoate transport; Region: 2A0115; TIGR00895 381754009045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754009046 putative substrate translocation pore; other site 381754009047 outer membrane porin, OprD family; Region: OprD; pfam03573 381754009048 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 381754009049 putative active site [active] 381754009050 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 381754009051 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 381754009052 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 381754009053 Predicted outer membrane protein [Function unknown]; Region: COG3652 381754009054 thiamine pyrophosphate protein; Provisional; Region: PRK08273 381754009055 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 381754009056 PYR/PP interface [polypeptide binding]; other site 381754009057 dimer interface [polypeptide binding]; other site 381754009058 tetramer interface [polypeptide binding]; other site 381754009059 TPP binding site [chemical binding]; other site 381754009060 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754009061 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 381754009062 TPP-binding site [chemical binding]; other site 381754009063 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 381754009064 dimerization interface [polypeptide binding]; other site 381754009065 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754009066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754009067 putative DNA binding site [nucleotide binding]; other site 381754009068 putative Zn2+ binding site [ion binding]; other site 381754009069 AsnC family; Region: AsnC_trans_reg; pfam01037 381754009070 arylformamidase; Region: trp_arylform; TIGR03035 381754009071 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 381754009072 kynureninase; Region: kynureninase; TIGR01814 381754009073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754009074 catalytic residue [active] 381754009075 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 381754009076 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754009077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754009078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754009080 dimerization interface [polypeptide binding]; other site 381754009081 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 381754009082 Predicted amidohydrolase [General function prediction only]; Region: COG0388 381754009083 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 381754009084 putative active site [active] 381754009085 catalytic triad [active] 381754009086 putative dimer interface [polypeptide binding]; other site 381754009087 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 381754009088 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 381754009089 Na binding site [ion binding]; other site 381754009090 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 381754009091 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 381754009092 PAS domain S-box; Region: sensory_box; TIGR00229 381754009093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754009094 putative active site [active] 381754009095 heme pocket [chemical binding]; other site 381754009096 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754009097 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754009098 metal binding site [ion binding]; metal-binding site 381754009099 active site 381754009100 I-site; other site 381754009101 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754009102 elongation factor G; Reviewed; Region: PRK00007 381754009103 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 381754009104 G1 box; other site 381754009105 putative GEF interaction site [polypeptide binding]; other site 381754009106 GTP/Mg2+ binding site [chemical binding]; other site 381754009107 Switch I region; other site 381754009108 G2 box; other site 381754009109 G3 box; other site 381754009110 Switch II region; other site 381754009111 G4 box; other site 381754009112 G5 box; other site 381754009113 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 381754009114 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 381754009115 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 381754009116 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 381754009117 active site 1 [active] 381754009118 dimer interface [polypeptide binding]; other site 381754009119 hexamer interface [polypeptide binding]; other site 381754009120 active site 2 [active] 381754009121 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 381754009122 classical (c) SDRs; Region: SDR_c; cd05233 381754009123 NAD(P) binding site [chemical binding]; other site 381754009124 active site 381754009125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754009126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009127 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754009128 putative effector binding pocket; other site 381754009129 dimerization interface [polypeptide binding]; other site 381754009130 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 381754009131 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 381754009132 phenyl proprionate permease family protein; Region: 2A0127; TIGR00902 381754009133 MFS_1 like family; Region: MFS_1_like; pfam12832 381754009134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754009135 putative substrate translocation pore; other site 381754009136 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 381754009137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754009138 motif II; other site 381754009139 Uncharacterized conserved protein [Function unknown]; Region: COG1434 381754009140 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 381754009141 putative active site [active] 381754009142 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 381754009143 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 381754009144 Multicopper oxidase; Region: Cu-oxidase; pfam00394 381754009145 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 381754009146 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 381754009147 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 381754009148 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 381754009149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009150 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 381754009151 dimerization interface [polypeptide binding]; other site 381754009152 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 381754009153 active site clefts [active] 381754009154 zinc binding site [ion binding]; other site 381754009155 dimer interface [polypeptide binding]; other site 381754009156 cyanate hydratase; Validated; Region: PRK02866 381754009157 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 381754009158 oligomer interface [polypeptide binding]; other site 381754009159 active site 381754009160 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 381754009161 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 381754009162 metal binding site [ion binding]; metal-binding site 381754009163 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 381754009164 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 381754009165 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 381754009166 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 381754009167 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754009168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754009169 Haemolytic domain; Region: Haemolytic; pfam01809 381754009170 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 381754009171 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 381754009172 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 381754009173 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 381754009174 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 381754009175 probable active site [active] 381754009176 serine/threonine transporter SstT; Provisional; Region: PRK13628 381754009177 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 381754009178 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 381754009179 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 381754009180 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 381754009181 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381754009182 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 381754009183 Predicted membrane protein [Function unknown]; Region: COG4392 381754009184 thiamine pyrophosphate protein; Validated; Region: PRK08199 381754009185 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 381754009186 PYR/PP interface [polypeptide binding]; other site 381754009187 dimer interface [polypeptide binding]; other site 381754009188 TPP binding site [chemical binding]; other site 381754009189 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754009190 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 381754009191 TPP-binding site [chemical binding]; other site 381754009192 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 381754009193 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 381754009194 FAD binding pocket [chemical binding]; other site 381754009195 FAD binding motif [chemical binding]; other site 381754009196 phosphate binding motif [ion binding]; other site 381754009197 NAD binding pocket [chemical binding]; other site 381754009198 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754009199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754009200 DNA-binding site [nucleotide binding]; DNA binding site 381754009201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754009202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754009203 homodimer interface [polypeptide binding]; other site 381754009204 catalytic residue [active] 381754009205 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 381754009206 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 381754009207 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754009208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754009209 putative DNA binding site [nucleotide binding]; other site 381754009210 putative Zn2+ binding site [ion binding]; other site 381754009211 AsnC family; Region: AsnC_trans_reg; pfam01037 381754009212 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 381754009213 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 381754009214 glutathione reductase; Validated; Region: PRK06116 381754009215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754009216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754009217 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 381754009218 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754009219 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 381754009220 active site 381754009221 metal binding site [ion binding]; metal-binding site 381754009222 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 381754009223 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 381754009224 active site 381754009225 tetramer interface; other site 381754009226 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 381754009227 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 381754009228 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 381754009229 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 381754009230 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 381754009231 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 381754009232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754009233 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754009234 multidrug efflux protein; Reviewed; Region: PRK09577 381754009235 Protein export membrane protein; Region: SecD_SecF; cl14618 381754009236 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 381754009237 SdiA-regulated; Region: SdiA-regulated; pfam06977 381754009238 SdiA-regulated; Region: SdiA-regulated; cd09971 381754009239 putative active site [active] 381754009240 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 381754009241 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 381754009242 DNA binding residues [nucleotide binding] 381754009243 putative dimer interface [polypeptide binding]; other site 381754009244 isovaleryl-CoA dehydrogenase; Region: PLN02519 381754009245 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 381754009246 substrate binding site [chemical binding]; other site 381754009247 FAD binding site [chemical binding]; other site 381754009248 catalytic base [active] 381754009249 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 381754009250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 381754009251 substrate binding site [chemical binding]; other site 381754009252 oxyanion hole (OAH) forming residues; other site 381754009253 trimer interface [polypeptide binding]; other site 381754009254 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 381754009255 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 381754009256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754009257 substrate binding site [chemical binding]; other site 381754009258 oxyanion hole (OAH) forming residues; other site 381754009259 trimer interface [polypeptide binding]; other site 381754009260 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 381754009261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 381754009262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754009263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 381754009264 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 381754009265 carboxyltransferase (CT) interaction site; other site 381754009266 biotinylation site [posttranslational modification]; other site 381754009267 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 381754009268 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 381754009269 active site 381754009270 catalytic residues [active] 381754009271 metal binding site [ion binding]; metal-binding site 381754009272 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 381754009273 Transcriptional regulator [Transcription]; Region: IclR; COG1414 381754009274 Bacterial transcriptional regulator; Region: IclR; pfam01614 381754009275 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 381754009276 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 381754009277 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 381754009278 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 381754009279 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 381754009280 C-terminal domain interface [polypeptide binding]; other site 381754009281 GSH binding site (G-site) [chemical binding]; other site 381754009282 maleylacetoacetate isomerase; Region: maiA; TIGR01262 381754009283 putative dimer interface [polypeptide binding]; other site 381754009284 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 381754009285 N-terminal domain interface [polypeptide binding]; other site 381754009286 dimer interface [polypeptide binding]; other site 381754009287 substrate binding pocket (H-site) [chemical binding]; other site 381754009288 benzoate transport; Region: 2A0115; TIGR00895 381754009289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754009290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754009291 PAS domain; Region: PAS; smart00091 381754009292 PAS fold; Region: PAS_4; pfam08448 381754009293 putative active site [active] 381754009294 heme pocket [chemical binding]; other site 381754009295 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 381754009296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754009297 Walker B motif; other site 381754009298 arginine finger; other site 381754009299 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754009300 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 381754009301 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 381754009302 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 381754009303 NAD binding site [chemical binding]; other site 381754009304 homotetramer interface [polypeptide binding]; other site 381754009305 homodimer interface [polypeptide binding]; other site 381754009306 substrate binding site [chemical binding]; other site 381754009307 active site 381754009308 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 381754009309 Prephenate dehydratase; Region: PDT; pfam00800 381754009310 Cupin domain; Region: Cupin_2; pfam07883 381754009311 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 381754009312 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 381754009313 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754009314 dimer interface [polypeptide binding]; other site 381754009315 active site 381754009316 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 381754009317 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 381754009318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754009319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009320 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 381754009321 putative dimerization interface [polypeptide binding]; other site 381754009322 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 381754009323 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 381754009324 acyl-activating enzyme (AAE) consensus motif; other site 381754009325 putative AMP binding site [chemical binding]; other site 381754009326 putative active site [active] 381754009327 putative CoA binding site [chemical binding]; other site 381754009328 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 381754009329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 381754009330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 381754009331 major facilitator superfamily transporter; Provisional; Region: PRK05122 381754009332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754009333 putative substrate translocation pore; other site 381754009334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 381754009335 PAS domain S-box; Region: sensory_box; TIGR00229 381754009336 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 381754009337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754009338 dimer interface [polypeptide binding]; other site 381754009339 phosphorylation site [posttranslational modification] 381754009340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754009341 ATP binding site [chemical binding]; other site 381754009342 Mg2+ binding site [ion binding]; other site 381754009343 G-X-G motif; other site 381754009344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754009345 active site 381754009346 phosphorylation site [posttranslational modification] 381754009347 intermolecular recognition site; other site 381754009348 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 381754009349 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 381754009350 putative active site [active] 381754009351 metal binding site [ion binding]; metal-binding site 381754009352 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 381754009353 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381754009354 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 381754009355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754009356 FeS/SAM binding site; other site 381754009357 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 381754009358 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 381754009359 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 381754009360 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 381754009361 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 381754009362 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 381754009363 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 381754009364 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 381754009365 NAD(P) binding site [chemical binding]; other site 381754009366 catalytic residues [active] 381754009367 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754009368 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 381754009369 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 381754009370 dimer interface [polypeptide binding]; other site 381754009371 Trp docking motif [polypeptide binding]; other site 381754009372 active site 381754009373 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 381754009374 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 381754009375 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 381754009376 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 381754009377 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 381754009378 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 381754009379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754009380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754009381 active site 381754009382 phosphorylation site [posttranslational modification] 381754009383 intermolecular recognition site; other site 381754009384 dimerization interface [polypeptide binding]; other site 381754009385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754009386 DNA binding residues [nucleotide binding] 381754009387 dimerization interface [polypeptide binding]; other site 381754009388 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754009389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754009390 active site 381754009391 phosphorylation site [posttranslational modification] 381754009392 intermolecular recognition site; other site 381754009393 dimerization interface [polypeptide binding]; other site 381754009394 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754009395 DNA binding residues [nucleotide binding] 381754009396 dimerization interface [polypeptide binding]; other site 381754009397 PAS fold; Region: PAS_7; pfam12860 381754009398 PAS fold; Region: PAS_7; pfam12860 381754009399 PAS fold; Region: PAS_4; pfam08448 381754009400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754009401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754009402 dimer interface [polypeptide binding]; other site 381754009403 phosphorylation site [posttranslational modification] 381754009404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754009405 ATP binding site [chemical binding]; other site 381754009406 Mg2+ binding site [ion binding]; other site 381754009407 G-X-G motif; other site 381754009408 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381754009409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754009410 active site 381754009411 phosphorylation site [posttranslational modification] 381754009412 intermolecular recognition site; other site 381754009413 dimerization interface [polypeptide binding]; other site 381754009414 Uncharacterized conserved protein [Function unknown]; Region: COG3287 381754009415 FIST N domain; Region: FIST; pfam08495 381754009416 FIST C domain; Region: FIST_C; pfam10442 381754009417 Gram-negative porin; Region: Porin_4; pfam13609 381754009418 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 381754009419 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 381754009420 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 381754009421 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 381754009422 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 381754009423 Sulfatase; Region: Sulfatase; pfam00884 381754009424 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 381754009425 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 381754009426 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 381754009427 putative substrate binding pocket [chemical binding]; other site 381754009428 trimer interface [polypeptide binding]; other site 381754009429 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 381754009430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754009431 Walker A/P-loop; other site 381754009432 ATP binding site [chemical binding]; other site 381754009433 Q-loop/lid; other site 381754009434 ABC transporter signature motif; other site 381754009435 Walker B; other site 381754009436 D-loop; other site 381754009437 H-loop/switch region; other site 381754009438 ABC transporter; Region: ABC_tran_2; pfam12848 381754009439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754009440 azoreductase; Reviewed; Region: PRK00170 381754009441 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754009442 LysR family transcriptional regulator; Provisional; Region: PRK14997 381754009443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754009445 dimerization interface [polypeptide binding]; other site 381754009446 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 381754009447 DNA-binding site [nucleotide binding]; DNA binding site 381754009448 RNA-binding motif; other site 381754009449 Predicted membrane protein [Function unknown]; Region: COG3326 381754009450 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 381754009451 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 381754009452 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 381754009453 AAA domain; Region: AAA_28; pfam13521 381754009454 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 381754009455 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 381754009456 substrate binding site [chemical binding]; other site 381754009457 dimer interface [polypeptide binding]; other site 381754009458 ATP binding site [chemical binding]; other site 381754009459 Transcriptional regulators [Transcription]; Region: PurR; COG1609 381754009460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381754009461 DNA binding site [nucleotide binding] 381754009462 domain linker motif; other site 381754009463 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 381754009464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381754009465 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 381754009466 TM-ABC transporter signature motif; other site 381754009467 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 381754009468 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 381754009469 Walker A/P-loop; other site 381754009470 ATP binding site [chemical binding]; other site 381754009471 Q-loop/lid; other site 381754009472 ABC transporter signature motif; other site 381754009473 Walker B; other site 381754009474 D-loop; other site 381754009475 H-loop/switch region; other site 381754009476 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 381754009477 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 381754009478 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 381754009479 ligand binding site [chemical binding]; other site 381754009480 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 381754009481 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 381754009482 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754009483 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 381754009484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754009485 Coenzyme A binding pocket [chemical binding]; other site 381754009486 Peptidase_C39 like family; Region: DUF3335; pfam11814 381754009487 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 381754009488 putative heme binding pocket [chemical binding]; other site 381754009489 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 381754009490 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 381754009491 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754009492 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 381754009493 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 381754009494 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 381754009495 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 381754009496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754009497 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 381754009498 putative active site [active] 381754009499 heme pocket [chemical binding]; other site 381754009500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754009501 putative active site [active] 381754009502 heme pocket [chemical binding]; other site 381754009503 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 381754009504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754009505 dimer interface [polypeptide binding]; other site 381754009506 putative CheW interface [polypeptide binding]; other site 381754009507 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754009508 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754009509 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 381754009510 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 381754009511 [2Fe-2S] cluster binding site [ion binding]; other site 381754009512 Erythromycin esterase; Region: Erythro_esteras; pfam05139 381754009513 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 381754009514 Uncharacterized conserved protein [Function unknown]; Region: COG4744 381754009515 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 381754009516 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 381754009517 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 381754009518 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 381754009519 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 381754009520 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754009521 N-terminal plug; other site 381754009522 ligand-binding site [chemical binding]; other site 381754009523 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 381754009524 ATP cone domain; Region: ATP-cone; pfam03477 381754009525 Class III ribonucleotide reductase; Region: RNR_III; cd01675 381754009526 effector binding site; other site 381754009527 active site 381754009528 Zn binding site [ion binding]; other site 381754009529 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 381754009530 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 381754009531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754009532 FeS/SAM binding site; other site 381754009533 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 381754009534 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 381754009535 RNA polymerase sigma factor; Provisional; Region: PRK12528 381754009536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754009537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754009538 DNA binding residues [nucleotide binding] 381754009539 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754009540 FecR protein; Region: FecR; pfam04773 381754009541 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 381754009542 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754009543 N-terminal plug; other site 381754009544 ligand-binding site [chemical binding]; other site 381754009545 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 381754009546 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 381754009547 RNA polymerase Rpb5, C-terminal domain; Region: RNA_pol_Rpb5_C; cl00883 381754009548 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 381754009549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754009550 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754009551 putative substrate translocation pore; other site 381754009552 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 381754009553 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 381754009554 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 381754009555 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 381754009556 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 381754009557 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 381754009558 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 381754009559 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 381754009560 Glutamine amidotransferase class-I; Region: GATase; pfam00117 381754009561 glutamine binding [chemical binding]; other site 381754009562 catalytic triad [active] 381754009563 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 381754009564 hydrophobic substrate binding pocket; other site 381754009565 Isochorismatase family; Region: Isochorismatase; pfam00857 381754009566 active site 381754009567 conserved cis-peptide bond; other site 381754009568 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 381754009569 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 381754009570 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 381754009571 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 381754009572 Autoinducer binding domain; Region: Autoind_bind; pfam03472 381754009573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754009574 DNA binding residues [nucleotide binding] 381754009575 dimerization interface [polypeptide binding]; other site 381754009576 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 381754009577 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 381754009578 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 381754009579 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 381754009580 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 381754009581 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 381754009582 active site 381754009583 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754009584 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 381754009585 putative C-terminal domain interface [polypeptide binding]; other site 381754009586 putative GSH binding site (G-site) [chemical binding]; other site 381754009587 putative dimer interface [polypeptide binding]; other site 381754009588 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 381754009589 putative N-terminal domain interface [polypeptide binding]; other site 381754009590 putative dimer interface [polypeptide binding]; other site 381754009591 putative substrate binding pocket (H-site) [chemical binding]; other site 381754009592 DNA polymerase II; Reviewed; Region: PRK05762 381754009593 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 381754009594 active site 381754009595 catalytic site [active] 381754009596 substrate binding site [chemical binding]; other site 381754009597 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 381754009598 active site 381754009599 metal-binding site 381754009600 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 381754009601 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754009602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754009603 sequence-specific DNA binding site [nucleotide binding]; other site 381754009604 salt bridge; other site 381754009605 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 381754009606 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 381754009607 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 381754009608 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754009609 catalytic loop [active] 381754009610 iron binding site [ion binding]; other site 381754009611 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 381754009612 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 381754009613 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754009614 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 381754009615 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754009616 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754009617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754009618 non-specific DNA binding site [nucleotide binding]; other site 381754009619 salt bridge; other site 381754009620 sequence-specific DNA binding site [nucleotide binding]; other site 381754009621 HD domain; Region: HD_3; pfam13023 381754009622 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 381754009623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754009624 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754009625 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 381754009626 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 381754009627 putative active site [active] 381754009628 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754009629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754009630 Walker A/P-loop; other site 381754009631 ATP binding site [chemical binding]; other site 381754009632 Q-loop/lid; other site 381754009633 ABC transporter signature motif; other site 381754009634 Walker B; other site 381754009635 D-loop; other site 381754009636 H-loop/switch region; other site 381754009637 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 381754009638 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 381754009639 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 381754009640 EcsC protein family; Region: EcsC; pfam12787 381754009641 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754009642 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754009643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754009644 EamA-like transporter family; Region: EamA; pfam00892 381754009645 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 381754009646 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 381754009647 Peptidase family M23; Region: Peptidase_M23; pfam01551 381754009648 acyl carrier protein; Provisional; Region: acpP; PRK00982 381754009649 type II secretion system protein D; Region: type_II_gspD; TIGR02517 381754009650 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754009651 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754009652 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754009653 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381754009654 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 381754009655 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 381754009656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 381754009657 DEAD_2; Region: DEAD_2; pfam06733 381754009658 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 381754009659 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 381754009660 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 381754009661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754009662 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 381754009663 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 381754009664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754009665 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 381754009666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754009667 dimer interface [polypeptide binding]; other site 381754009668 conserved gate region; other site 381754009669 putative PBP binding loops; other site 381754009670 ABC-ATPase subunit interface; other site 381754009671 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 381754009672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754009673 Walker A/P-loop; other site 381754009674 ATP binding site [chemical binding]; other site 381754009675 Q-loop/lid; other site 381754009676 ABC transporter signature motif; other site 381754009677 Walker B; other site 381754009678 D-loop; other site 381754009679 H-loop/switch region; other site 381754009680 TOBE domain; Region: TOBE; cl01440 381754009681 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 381754009682 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 381754009683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754009684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009685 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 381754009686 putative effector binding pocket; other site 381754009687 dimerization interface [polypeptide binding]; other site 381754009688 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 381754009689 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 381754009690 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 381754009691 Protein of unknown function (DUF808); Region: DUF808; pfam05661 381754009692 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 381754009693 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 381754009694 Low-spin heme binding site [chemical binding]; other site 381754009695 Putative water exit pathway; other site 381754009696 Binuclear center (active site) [active] 381754009697 Putative proton exit pathway; other site 381754009698 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 381754009699 HPP family; Region: HPP; pfam04982 381754009700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 381754009701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754009702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009703 LysR substrate binding domain; Region: LysR_substrate; pfam03466 381754009704 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754009705 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754009706 metal binding site [ion binding]; metal-binding site 381754009707 active site 381754009708 I-site; other site 381754009709 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 381754009710 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 381754009711 conserved cys residue [active] 381754009712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754009713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754009714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 381754009715 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 381754009716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754009717 putative substrate translocation pore; other site 381754009718 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 381754009719 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 381754009720 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 381754009721 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 381754009722 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 381754009723 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 381754009724 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 381754009725 substrate binding pocket [chemical binding]; other site 381754009726 dimer interface [polypeptide binding]; other site 381754009727 inhibitor binding site; inhibition site 381754009728 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 381754009729 B12 binding site [chemical binding]; other site 381754009730 cobalt ligand [ion binding]; other site 381754009731 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 381754009732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3171 381754009733 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 381754009734 putative deacylase active site [active] 381754009735 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 381754009736 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 381754009737 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 381754009738 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 381754009739 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 381754009740 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 381754009741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 381754009742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754009743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754009744 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754009745 CoenzymeA binding site [chemical binding]; other site 381754009746 subunit interaction site [polypeptide binding]; other site 381754009747 PHB binding site; other site 381754009748 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 381754009749 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754009750 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 381754009751 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 381754009752 NADP binding site [chemical binding]; other site 381754009753 dimer interface [polypeptide binding]; other site 381754009754 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 381754009755 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 381754009756 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 381754009757 tandem repeat interface [polypeptide binding]; other site 381754009758 oligomer interface [polypeptide binding]; other site 381754009759 active site residues [active] 381754009760 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 381754009761 catalytic core [active] 381754009762 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 381754009763 Phosphotransferase enzyme family; Region: APH; pfam01636 381754009764 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 381754009765 putative active site [active] 381754009766 putative substrate binding site [chemical binding]; other site 381754009767 ATP binding site [chemical binding]; other site 381754009768 short chain dehydrogenase; Provisional; Region: PRK07035 381754009769 classical (c) SDRs; Region: SDR_c; cd05233 381754009770 NAD(P) binding site [chemical binding]; other site 381754009771 active site 381754009772 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 381754009773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754009774 NAD(P) binding site [chemical binding]; other site 381754009775 active site 381754009776 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 381754009777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754009778 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 381754009779 dimerization interface [polypeptide binding]; other site 381754009780 substrate binding pocket [chemical binding]; other site 381754009781 hypothetical protein; Provisional; Region: PRK10621 381754009782 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 381754009783 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 381754009784 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 381754009785 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 381754009786 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 381754009787 putative NADH binding site [chemical binding]; other site 381754009788 putative active site [active] 381754009789 nudix motif; other site 381754009790 putative metal binding site [ion binding]; other site 381754009791 enoyl-CoA hydratase; Provisional; Region: PRK06142 381754009792 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754009793 substrate binding site [chemical binding]; other site 381754009794 oxyanion hole (OAH) forming residues; other site 381754009795 trimer interface [polypeptide binding]; other site 381754009796 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 381754009797 arginine:agmatin antiporter; Provisional; Region: PRK10644 381754009798 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 381754009799 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 381754009800 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 381754009801 homodimer interface [polypeptide binding]; other site 381754009802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754009803 catalytic residue [active] 381754009804 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 381754009805 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 381754009806 active site 381754009807 catalytic site [active] 381754009808 substrate binding site [chemical binding]; other site 381754009809 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 381754009810 RNA/DNA hybrid binding site [nucleotide binding]; other site 381754009811 active site 381754009812 Methyltransferase domain; Region: Methyltransf_23; pfam13489 381754009813 Methyltransferase domain; Region: Methyltransf_11; pfam08241 381754009814 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 381754009815 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 381754009816 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754009817 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754009818 catalytic residue [active] 381754009819 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754009820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754009821 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 381754009822 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754009823 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 381754009824 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 381754009825 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 381754009826 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 381754009827 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 381754009828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754009829 dimer interface [polypeptide binding]; other site 381754009830 conserved gate region; other site 381754009831 putative PBP binding loops; other site 381754009832 ABC-ATPase subunit interface; other site 381754009833 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 381754009834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754009835 dimer interface [polypeptide binding]; other site 381754009836 conserved gate region; other site 381754009837 putative PBP binding loops; other site 381754009838 ABC-ATPase subunit interface; other site 381754009839 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 381754009840 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381754009841 Walker A/P-loop; other site 381754009842 ATP binding site [chemical binding]; other site 381754009843 Q-loop/lid; other site 381754009844 ABC transporter signature motif; other site 381754009845 Walker B; other site 381754009846 D-loop; other site 381754009847 H-loop/switch region; other site 381754009848 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 381754009849 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381754009850 Walker A/P-loop; other site 381754009851 ATP binding site [chemical binding]; other site 381754009852 Q-loop/lid; other site 381754009853 ABC transporter signature motif; other site 381754009854 Walker B; other site 381754009855 D-loop; other site 381754009856 H-loop/switch region; other site 381754009857 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 381754009858 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 381754009859 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 381754009860 NAD binding site [chemical binding]; other site 381754009861 homotetramer interface [polypeptide binding]; other site 381754009862 homodimer interface [polypeptide binding]; other site 381754009863 substrate binding site [chemical binding]; other site 381754009864 active site 381754009865 periplasmic folding chaperone; Provisional; Region: PRK10788 381754009866 SurA N-terminal domain; Region: SurA_N_3; pfam13624 381754009867 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 381754009868 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 381754009869 IHF dimer interface [polypeptide binding]; other site 381754009870 IHF - DNA interface [nucleotide binding]; other site 381754009871 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 381754009872 Found in ATP-dependent protease La (LON); Region: LON; smart00464 381754009873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754009874 Walker A motif; other site 381754009875 ATP binding site [chemical binding]; other site 381754009876 Walker B motif; other site 381754009877 arginine finger; other site 381754009878 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 381754009879 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 381754009880 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 381754009881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754009882 Walker A motif; other site 381754009883 ATP binding site [chemical binding]; other site 381754009884 Walker B motif; other site 381754009885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 381754009886 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 381754009887 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 381754009888 oligomer interface [polypeptide binding]; other site 381754009889 active site residues [active] 381754009890 trigger factor; Provisional; Region: tig; PRK01490 381754009891 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 381754009892 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 381754009893 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 381754009894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754009895 active site 381754009896 phosphorylation site [posttranslational modification] 381754009897 intermolecular recognition site; other site 381754009898 dimerization interface [polypeptide binding]; other site 381754009899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754009900 DNA binding site [nucleotide binding] 381754009901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754009902 dimerization interface [polypeptide binding]; other site 381754009903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754009904 dimer interface [polypeptide binding]; other site 381754009905 phosphorylation site [posttranslational modification] 381754009906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754009907 ATP binding site [chemical binding]; other site 381754009908 Mg2+ binding site [ion binding]; other site 381754009909 G-X-G motif; other site 381754009910 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 381754009911 Beta-lactamase; Region: Beta-lactamase; pfam00144 381754009912 MltA-interacting protein MipA; Region: MipA; cl01504 381754009913 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 381754009914 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 381754009915 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 381754009916 homodimer interface [polypeptide binding]; other site 381754009917 NADP binding site [chemical binding]; other site 381754009918 substrate binding site [chemical binding]; other site 381754009919 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 381754009920 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 381754009921 active site 381754009922 HIGH motif; other site 381754009923 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 381754009924 KMSKS motif; other site 381754009925 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 381754009926 tRNA binding surface [nucleotide binding]; other site 381754009927 anticodon binding site; other site 381754009928 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 381754009929 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 381754009930 active site 381754009931 HIGH motif; other site 381754009932 nucleotide binding site [chemical binding]; other site 381754009933 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 381754009934 KMSKS motif; other site 381754009935 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 381754009936 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 381754009937 substrate binding site [chemical binding]; other site 381754009938 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381754009939 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 381754009940 putative active site [active] 381754009941 putative metal binding site [ion binding]; other site 381754009942 SPFH domain / Band 7 family; Region: Band_7; pfam01145 381754009943 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 381754009944 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 381754009945 active site 381754009946 dinuclear metal binding site [ion binding]; other site 381754009947 dimerization interface [polypeptide binding]; other site 381754009948 universal stress protein UspE; Provisional; Region: PRK11175 381754009949 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754009950 Ligand Binding Site [chemical binding]; other site 381754009951 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754009952 Ligand Binding Site [chemical binding]; other site 381754009953 Predicted Fe-S protein [General function prediction only]; Region: COG3313 381754009954 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 381754009955 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 381754009956 substrate binding site [chemical binding]; other site 381754009957 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 381754009958 substrate binding site [chemical binding]; other site 381754009959 ligand binding site [chemical binding]; other site 381754009960 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 381754009961 NMT1-like family; Region: NMT1_2; pfam13379 381754009962 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 381754009963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754009964 active site 381754009965 phosphorylation site [posttranslational modification] 381754009966 intermolecular recognition site; other site 381754009967 dimerization interface [polypeptide binding]; other site 381754009968 ANTAR domain; Region: ANTAR; pfam03861 381754009969 Alginate lyase; Region: Alginate_lyase2; pfam08787 381754009970 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 381754009971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754009972 putative substrate translocation pore; other site 381754009973 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 381754009974 active site 381754009975 Protein kinase domain; Region: Pkinase; pfam00069 381754009976 Catalytic domain of Protein Kinases; Region: PKc; cd00180 381754009977 active site 381754009978 ATP binding site [chemical binding]; other site 381754009979 substrate binding site [chemical binding]; other site 381754009980 activation loop (A-loop); other site 381754009981 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 381754009982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754009983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754009984 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 381754009985 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 381754009986 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 381754009987 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 381754009988 [2Fe-2S] cluster binding site [ion binding]; other site 381754009989 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 381754009990 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 381754009991 [4Fe-4S] binding site [ion binding]; other site 381754009992 molybdopterin cofactor binding site; other site 381754009993 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 381754009994 molybdopterin cofactor binding site; other site 381754009995 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 381754009996 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 381754009997 active site 381754009998 SAM binding site [chemical binding]; other site 381754009999 homodimer interface [polypeptide binding]; other site 381754010000 OprF membrane domain; Region: OprF; pfam05736 381754010001 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754010002 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754010003 ligand binding site [chemical binding]; other site 381754010004 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 381754010005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754010006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754010007 DNA binding residues [nucleotide binding] 381754010008 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381754010009 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 381754010010 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 381754010011 Cl binding site [ion binding]; other site 381754010012 oligomer interface [polypeptide binding]; other site 381754010013 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 381754010014 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754010015 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754010016 phosphoenolpyruvate synthase; Validated; Region: PRK06464 381754010017 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 381754010018 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 381754010019 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 381754010020 PEP synthetase regulatory protein; Provisional; Region: PRK05339 381754010021 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 381754010022 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 381754010023 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 381754010024 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 381754010025 Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148 381754010026 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 381754010027 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 381754010028 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 381754010029 putative active site [active] 381754010030 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 381754010031 AAA ATPase domain; Region: AAA_16; pfam13191 381754010032 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754010033 DNA binding residues [nucleotide binding] 381754010034 dimerization interface [polypeptide binding]; other site 381754010035 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 381754010036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754010037 DNA binding residues [nucleotide binding] 381754010038 dimerization interface [polypeptide binding]; other site 381754010039 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 381754010040 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 381754010041 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 381754010042 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 381754010043 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 381754010044 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 381754010045 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 381754010046 Active Sites [active] 381754010047 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 381754010048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754010049 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 381754010050 substrate binding site [chemical binding]; other site 381754010051 dimerization interface [polypeptide binding]; other site 381754010052 Variant erythrocyte surface antigen-1; Region: VESA1_N; pfam12785 381754010053 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754010054 Ligand Binding Site [chemical binding]; other site 381754010055 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 381754010056 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 381754010057 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 381754010058 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 381754010059 catalytic residues [active] 381754010060 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 381754010061 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 381754010062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754010063 Coenzyme A binding pocket [chemical binding]; other site 381754010064 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 381754010065 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754010066 substrate binding site [chemical binding]; other site 381754010067 oxyanion hole (OAH) forming residues; other site 381754010068 trimer interface [polypeptide binding]; other site 381754010069 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 381754010070 ADP-ribose binding site [chemical binding]; other site 381754010071 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 381754010072 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 381754010073 catalytic triad [active] 381754010074 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 381754010075 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 381754010076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754010077 substrate binding site [chemical binding]; other site 381754010078 oxyanion hole (OAH) forming residues; other site 381754010079 trimer interface [polypeptide binding]; other site 381754010080 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381754010081 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754010082 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 381754010083 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754010084 dimer interface [polypeptide binding]; other site 381754010085 active site 381754010086 Predicted permeases [General function prediction only]; Region: COG0679 381754010087 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754010088 Cytochrome c; Region: Cytochrom_C; pfam00034 381754010089 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 381754010090 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 381754010091 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 381754010092 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 381754010093 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 381754010094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 381754010095 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 381754010096 Uncharacterized conserved protein [Function unknown]; Region: COG2308 381754010097 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 381754010098 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 381754010099 catalytic triad [active] 381754010100 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 381754010101 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 381754010102 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 381754010103 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 381754010104 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754010105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754010106 metal binding site [ion binding]; metal-binding site 381754010107 active site 381754010108 I-site; other site 381754010109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754010110 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 381754010111 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 381754010112 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381754010113 Switch II region; other site 381754010114 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 381754010115 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 381754010116 Sulfatase; Region: Sulfatase; pfam00884 381754010117 Uncharacterized conserved protein [Function unknown]; Region: COG3391 381754010118 Strictosidine synthase; Region: Str_synth; pfam03088 381754010119 spermidine synthase; Provisional; Region: PRK00811 381754010120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754010121 S-adenosylmethionine binding site [chemical binding]; other site 381754010122 AlkA N-terminal domain; Region: AlkA_N; pfam06029 381754010123 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 381754010124 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 381754010125 minor groove reading motif; other site 381754010126 helix-hairpin-helix signature motif; other site 381754010127 substrate binding pocket [chemical binding]; other site 381754010128 active site 381754010129 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 381754010130 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 381754010131 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 381754010132 Cupin domain; Region: Cupin_2; cl17218 381754010133 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 381754010134 intersubunit interface [polypeptide binding]; other site 381754010135 active site 381754010136 Zn2+ binding site [ion binding]; other site 381754010137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754010138 putative substrate translocation pore; other site 381754010139 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 381754010140 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 381754010141 Tetramer interface [polypeptide binding]; other site 381754010142 active site 381754010143 FMN-binding site [chemical binding]; other site 381754010144 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 381754010145 HemK family putative methylases; Region: hemK_fam; TIGR00536 381754010146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754010147 S-adenosylmethionine binding site [chemical binding]; other site 381754010148 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 381754010149 Isochorismatase family; Region: Isochorismatase; pfam00857 381754010150 catalytic triad [active] 381754010151 conserved cis-peptide bond; other site 381754010152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 381754010153 Smr domain; Region: Smr; pfam01713 381754010154 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 381754010155 homodecamer interface [polypeptide binding]; other site 381754010156 GTP cyclohydrolase I; Provisional; Region: PLN03044 381754010157 active site 381754010158 putative catalytic site residues [active] 381754010159 zinc binding site [ion binding]; other site 381754010160 GTP-CH-I/GFRP interaction surface; other site 381754010161 Hemerythrin; Region: Hemerythrin; cd12107 381754010162 Fe binding site [ion binding]; other site 381754010163 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 381754010164 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754010165 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 381754010166 Catalytic domain of Protein Kinases; Region: PKc; cd00180 381754010167 active site 381754010168 ATP binding site [chemical binding]; other site 381754010169 substrate binding site [chemical binding]; other site 381754010170 activation loop (A-loop); other site 381754010171 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 381754010172 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 381754010173 Protein phosphatase 2C; Region: PP2C; pfam00481 381754010174 active site 381754010175 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 381754010176 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 381754010177 G1 box; other site 381754010178 GTP/Mg2+ binding site [chemical binding]; other site 381754010179 G2 box; other site 381754010180 Switch I region; other site 381754010181 G3 box; other site 381754010182 Switch II region; other site 381754010183 G4 box; other site 381754010184 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 381754010185 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 381754010186 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 381754010187 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 381754010188 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 381754010189 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 381754010190 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 381754010191 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 381754010192 phosphopeptide binding site; other site 381754010193 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 381754010194 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 381754010195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754010196 Walker A motif; other site 381754010197 ATP binding site [chemical binding]; other site 381754010198 Walker B motif; other site 381754010199 arginine finger; other site 381754010200 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754010201 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 381754010202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754010203 Walker A motif; other site 381754010204 ATP binding site [chemical binding]; other site 381754010205 Walker B motif; other site 381754010206 arginine finger; other site 381754010207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754010208 Walker A motif; other site 381754010209 ATP binding site [chemical binding]; other site 381754010210 Walker B motif; other site 381754010211 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 381754010212 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 381754010213 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 381754010214 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 381754010215 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 381754010216 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 381754010217 Protein of unknown function (DUF877); Region: DUF877; pfam05943 381754010218 Protein of unknown function (DUF770); Region: DUF770; pfam05591 381754010219 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 381754010220 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 381754010221 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 381754010222 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754010223 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 381754010224 putative C-terminal domain interface [polypeptide binding]; other site 381754010225 putative GSH binding site (G-site) [chemical binding]; other site 381754010226 putative dimer interface [polypeptide binding]; other site 381754010227 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 381754010228 N-terminal domain interface [polypeptide binding]; other site 381754010229 dimer interface [polypeptide binding]; other site 381754010230 substrate binding pocket (H-site) [chemical binding]; other site 381754010231 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 381754010232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754010233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754010234 homodimer interface [polypeptide binding]; other site 381754010235 catalytic residue [active] 381754010236 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 381754010237 MarR family; Region: MarR_2; pfam12802 381754010238 benzoate transporter; Region: benE; TIGR00843 381754010239 Benzoate membrane transport protein; Region: BenE; pfam03594 381754010240 bile acid transporter; Region: bass; TIGR00841 381754010241 Sodium Bile acid symporter family; Region: SBF; cl17470 381754010242 short chain dehydrogenase; Provisional; Region: PRK06172 381754010243 classical (c) SDRs; Region: SDR_c; cd05233 381754010244 NAD(P) binding site [chemical binding]; other site 381754010245 active site 381754010246 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 381754010247 Prostaglandin dehydrogenases; Region: PGDH; cd05288 381754010248 NAD(P) binding site [chemical binding]; other site 381754010249 substrate binding site [chemical binding]; other site 381754010250 dimer interface [polypeptide binding]; other site 381754010251 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 381754010252 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 381754010253 Sulfate transporter family; Region: Sulfate_transp; pfam00916 381754010254 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 381754010255 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 381754010256 acetoacetate decarboxylase; Provisional; Region: PRK02265 381754010257 Uncharacterized conserved protein [Function unknown]; Region: COG3791 381754010258 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 381754010259 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 381754010260 active site residue [active] 381754010261 selenophosphate synthetase; Provisional; Region: PRK00943 381754010262 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 381754010263 dimerization interface [polypeptide binding]; other site 381754010264 putative ATP binding site [chemical binding]; other site 381754010265 hypothetical protein; Provisional; Region: PRK10279 381754010266 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 381754010267 active site 381754010268 nucleophile elbow; other site 381754010269 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 381754010270 glutaminase; Provisional; Region: PRK00971 381754010271 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 381754010272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754010273 active site 381754010274 phosphorylation site [posttranslational modification] 381754010275 intermolecular recognition site; other site 381754010276 dimerization interface [polypeptide binding]; other site 381754010277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754010278 DNA binding site [nucleotide binding] 381754010279 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 381754010280 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 381754010281 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 381754010282 Ligand Binding Site [chemical binding]; other site 381754010283 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 381754010284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754010285 dimer interface [polypeptide binding]; other site 381754010286 phosphorylation site [posttranslational modification] 381754010287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754010288 ATP binding site [chemical binding]; other site 381754010289 Mg2+ binding site [ion binding]; other site 381754010290 G-X-G motif; other site 381754010291 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 381754010292 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 381754010293 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381754010294 Soluble P-type ATPase [General function prediction only]; Region: COG4087 381754010295 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 381754010296 potassium-transporting ATPase subunit F; Provisional; Region: kdbF; PRK14740 381754010297 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754010298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754010299 active site 381754010300 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 381754010301 Transcriptional regulator [Transcription]; Region: IclR; COG1414 381754010302 Bacterial transcriptional regulator; Region: IclR; pfam01614 381754010303 enoyl-CoA hydratase; Provisional; Region: PRK08138 381754010304 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754010305 substrate binding site [chemical binding]; other site 381754010306 oxyanion hole (OAH) forming residues; other site 381754010307 trimer interface [polypeptide binding]; other site 381754010308 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 381754010309 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381754010310 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754010311 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754010312 Transcriptional regulators [Transcription]; Region: FadR; COG2186 381754010313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754010314 DNA-binding site [nucleotide binding]; DNA binding site 381754010315 FCD domain; Region: FCD; pfam07729 381754010316 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 381754010317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754010318 putative substrate translocation pore; other site 381754010319 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 381754010320 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 381754010321 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 381754010322 C-terminal domain interface [polypeptide binding]; other site 381754010323 GSH binding site (G-site) [chemical binding]; other site 381754010324 dimer interface [polypeptide binding]; other site 381754010325 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 381754010326 N-terminal domain interface [polypeptide binding]; other site 381754010327 dimer interface [polypeptide binding]; other site 381754010328 substrate binding pocket (H-site) [chemical binding]; other site 381754010329 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754010330 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754010331 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754010332 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754010333 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754010334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754010335 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754010336 CoenzymeA binding site [chemical binding]; other site 381754010337 subunit interaction site [polypeptide binding]; other site 381754010338 PHB binding site; other site 381754010339 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 381754010340 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 381754010341 acyl-activating enzyme (AAE) consensus motif; other site 381754010342 putative AMP binding site [chemical binding]; other site 381754010343 putative active site [active] 381754010344 putative CoA binding site [chemical binding]; other site 381754010345 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 381754010346 catalytic core [active] 381754010347 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 381754010348 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 381754010349 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 381754010350 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 381754010351 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 381754010352 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 381754010353 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 381754010354 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 381754010355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754010356 dimerization interface [polypeptide binding]; other site 381754010357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754010358 dimer interface [polypeptide binding]; other site 381754010359 phosphorylation site [posttranslational modification] 381754010360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754010361 ATP binding site [chemical binding]; other site 381754010362 Mg2+ binding site [ion binding]; other site 381754010363 G-X-G motif; other site 381754010364 Response regulator receiver domain; Region: Response_reg; pfam00072 381754010365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754010366 active site 381754010367 phosphorylation site [posttranslational modification] 381754010368 intermolecular recognition site; other site 381754010369 dimerization interface [polypeptide binding]; other site 381754010370 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 381754010371 active site 1 [active] 381754010372 dimer interface [polypeptide binding]; other site 381754010373 active site 2 [active] 381754010374 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 381754010375 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 381754010376 dimer interface [polypeptide binding]; other site 381754010377 active site 381754010378 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 381754010379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754010380 dimerization interface [polypeptide binding]; other site 381754010381 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754010382 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754010383 dimer interface [polypeptide binding]; other site 381754010384 putative CheW interface [polypeptide binding]; other site 381754010385 Predicted transcriptional regulators [Transcription]; Region: COG1733 381754010386 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 381754010387 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 381754010388 Amidohydrolase; Region: Amidohydro_2; pfam04909 381754010389 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754010390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 381754010391 MarR family; Region: MarR; pfam01047 381754010392 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 381754010393 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754010394 catalytic loop [active] 381754010395 iron binding site [ion binding]; other site 381754010396 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 381754010397 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 381754010398 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754010399 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 381754010400 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754010401 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754010402 cytochrome c-550; Provisional; Region: psbV; cl17239 381754010403 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754010404 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754010405 Cupin domain; Region: Cupin_2; cl17218 381754010406 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754010407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754010408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754010409 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 381754010410 oligomerization interface [polypeptide binding]; other site 381754010411 active site 381754010412 metal binding site [ion binding]; metal-binding site 381754010413 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 381754010414 heat shock protein 90; Provisional; Region: PRK05218 381754010415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754010416 ATP binding site [chemical binding]; other site 381754010417 Mg2+ binding site [ion binding]; other site 381754010418 G-X-G motif; other site 381754010419 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 381754010420 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754010421 CoenzymeA binding site [chemical binding]; other site 381754010422 subunit interaction site [polypeptide binding]; other site 381754010423 PHB binding site; other site 381754010424 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754010425 CoenzymeA binding site [chemical binding]; other site 381754010426 subunit interaction site [polypeptide binding]; other site 381754010427 PHB binding site; other site 381754010428 Predicted membrane protein [Function unknown]; Region: COG3821 381754010429 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 381754010430 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 381754010431 CoA binding domain; Region: CoA_binding; pfam02629 381754010432 CoA-ligase; Region: Ligase_CoA; pfam00549 381754010433 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 381754010434 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 381754010435 CoA-ligase; Region: Ligase_CoA; pfam00549 381754010436 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 381754010437 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 381754010438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754010439 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 381754010440 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 381754010441 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 381754010442 E3 interaction surface; other site 381754010443 lipoyl attachment site [posttranslational modification]; other site 381754010444 e3 binding domain; Region: E3_binding; pfam02817 381754010445 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 381754010446 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 381754010447 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 381754010448 TPP-binding site [chemical binding]; other site 381754010449 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 381754010450 PYR/PP interface [polypeptide binding]; other site 381754010451 dimer interface [polypeptide binding]; other site 381754010452 TPP binding site [chemical binding]; other site 381754010453 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 381754010454 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 381754010455 L-aspartate oxidase; Provisional; Region: PRK06175 381754010456 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 381754010457 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 381754010458 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 381754010459 SdhC subunit interface [polypeptide binding]; other site 381754010460 proximal heme binding site [chemical binding]; other site 381754010461 cardiolipin binding site; other site 381754010462 Iron-sulfur protein interface; other site 381754010463 proximal quinone binding site [chemical binding]; other site 381754010464 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 381754010465 Iron-sulfur protein interface; other site 381754010466 proximal quinone binding site [chemical binding]; other site 381754010467 SdhD (CybS) interface [polypeptide binding]; other site 381754010468 proximal heme binding site [chemical binding]; other site 381754010469 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 381754010470 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 381754010471 dimer interface [polypeptide binding]; other site 381754010472 active site 381754010473 citrylCoA binding site [chemical binding]; other site 381754010474 NADH binding [chemical binding]; other site 381754010475 cationic pore residues; other site 381754010476 oxalacetate/citrate binding site [chemical binding]; other site 381754010477 coenzyme A binding site [chemical binding]; other site 381754010478 catalytic triad [active] 381754010479 Helix-turn-helix domain; Region: HTH_17; pfam12728 381754010480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754010481 ATP binding site [chemical binding]; other site 381754010482 putative Mg++ binding site [ion binding]; other site 381754010483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754010484 nucleotide binding region [chemical binding]; other site 381754010485 ATP-binding site [chemical binding]; other site 381754010486 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 381754010487 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 381754010488 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 381754010489 VirB7 interaction site; other site 381754010490 conjugal transfer protein TrbF; Provisional; Region: PRK13872 381754010491 conjugal transfer protein TrbL; Provisional; Region: PRK13875 381754010492 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 381754010493 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 381754010494 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 381754010495 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 381754010496 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 381754010497 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 381754010498 Walker A motif; other site 381754010499 ATP binding site [chemical binding]; other site 381754010500 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 381754010501 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 381754010502 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 381754010503 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 381754010504 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 381754010505 ATP binding site [chemical binding]; other site 381754010506 Walker A motif; other site 381754010507 hexamer interface [polypeptide binding]; other site 381754010508 Walker B motif; other site 381754010509 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 381754010510 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 381754010511 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 381754010512 Walker A motif; other site 381754010513 ATP binding site [chemical binding]; other site 381754010514 Walker B motif; other site 381754010515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754010516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754010517 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 381754010518 dimerization interface [polypeptide binding]; other site 381754010519 substrate binding pocket [chemical binding]; other site 381754010520 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 381754010521 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 381754010522 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 381754010523 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381754010524 Soluble P-type ATPase [General function prediction only]; Region: COG4087 381754010525 K+-transporting ATPase, c chain; Region: KdpC; cl00944 381754010526 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 381754010527 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 381754010528 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 381754010529 Ligand Binding Site [chemical binding]; other site 381754010530 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 381754010531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754010532 dimer interface [polypeptide binding]; other site 381754010533 phosphorylation site [posttranslational modification] 381754010534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754010535 ATP binding site [chemical binding]; other site 381754010536 Mg2+ binding site [ion binding]; other site 381754010537 G-X-G motif; other site 381754010538 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754010539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754010540 active site 381754010541 phosphorylation site [posttranslational modification] 381754010542 intermolecular recognition site; other site 381754010543 dimerization interface [polypeptide binding]; other site 381754010544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754010545 DNA binding site [nucleotide binding] 381754010546 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 381754010547 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 381754010548 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 381754010549 dimer interface [polypeptide binding]; other site 381754010550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754010551 ligand binding site [chemical binding]; other site 381754010552 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 381754010553 Phosphotransferase enzyme family; Region: APH; pfam01636 381754010554 active site 381754010555 ATP binding site [chemical binding]; other site 381754010556 antibiotic binding site [chemical binding]; other site 381754010557 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754010558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754010559 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 381754010560 dimerization interface [polypeptide binding]; other site 381754010561 substrate binding pocket [chemical binding]; other site 381754010562 EamA-like transporter family; Region: EamA; pfam00892 381754010563 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754010564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754010565 non-specific DNA binding site [nucleotide binding]; other site 381754010566 salt bridge; other site 381754010567 sequence-specific DNA binding site [nucleotide binding]; other site 381754010568 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 381754010569 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 381754010570 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 381754010571 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 381754010572 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 381754010573 ParA-like protein; Provisional; Region: PHA02518 381754010574 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754010575 P-loop; other site 381754010576 Magnesium ion binding site [ion binding]; other site 381754010577 Replication initiator protein A; Region: RPA; cl17860 381754010578 Helix-turn-helix domain; Region: HTH_17; cl17695 381754010579 Uncharacterized conserved protein [Function unknown]; Region: COG5419 381754010580 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 381754010581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 381754010582 sequence-specific DNA binding site [nucleotide binding]; other site 381754010583 salt bridge; other site 381754010584 Homeodomain-like domain; Region: HTH_23; cl17451 381754010585 Winged helix-turn helix; Region: HTH_29; pfam13551 381754010586 Integrase core domain; Region: rve; pfam00665 381754010587 Integrase core domain; Region: rve_3; pfam13683 381754010588 Uncharacterized conserved protein [Function unknown]; Region: COG5489 381754010589 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 381754010590 Domain of unknown function (DUF932); Region: DUF932; pfam06067 381754010591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754010592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754010593 non-specific DNA binding site [nucleotide binding]; other site 381754010594 salt bridge; other site 381754010595 sequence-specific DNA binding site [nucleotide binding]; other site 381754010596 Helix-turn-helix domain; Region: HTH_37; pfam13744 381754010597 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 381754010598 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754010599 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 381754010600 active site 381754010601 Int/Topo IB signature motif; other site 381754010602 DNA binding site [nucleotide binding] 381754010603 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 381754010604 putative lipid binding site [chemical binding]; other site 381754010605 Flagellin N-methylase; Region: FliB; cl00497 381754010606 Protein of unknown function, DUF486; Region: DUF486; pfam04342 381754010607 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 381754010608 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 381754010609 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 381754010610 active site 381754010611 catalytic site [active] 381754010612 substrate binding site [chemical binding]; other site 381754010613 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 381754010614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 381754010615 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 381754010616 ATP-NAD kinase; Region: NAD_kinase; pfam01513 381754010617 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 381754010618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754010619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754010620 dimerization interface [polypeptide binding]; other site 381754010621 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 381754010622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754010623 putative substrate translocation pore; other site 381754010624 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 381754010625 homotrimer interaction site [polypeptide binding]; other site 381754010626 putative active site [active] 381754010627 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754010628 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754010629 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 381754010630 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381754010631 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754010632 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754010633 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 381754010634 CPxP motif; other site 381754010635 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 381754010636 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 381754010637 aconitate hydratase; Validated; Region: PRK09277 381754010638 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 381754010639 substrate binding site [chemical binding]; other site 381754010640 ligand binding site [chemical binding]; other site 381754010641 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 381754010642 substrate binding site [chemical binding]; other site 381754010643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754010644 PAS domain; Region: PAS_9; pfam13426 381754010645 putative active site [active] 381754010646 heme pocket [chemical binding]; other site 381754010647 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754010648 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754010649 dimer interface [polypeptide binding]; other site 381754010650 putative CheW interface [polypeptide binding]; other site 381754010651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754010652 NAD(P) binding site [chemical binding]; other site 381754010653 active site 381754010654 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 381754010655 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 381754010656 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 381754010657 Low-spin heme binding site [chemical binding]; other site 381754010658 Putative water exit pathway; other site 381754010659 Binuclear center (active site) [active] 381754010660 Putative proton exit pathway; other site 381754010661 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 381754010662 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 381754010663 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 381754010664 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 381754010665 Cytochrome c; Region: Cytochrom_C; pfam00034 381754010666 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754010667 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 381754010668 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 381754010669 Low-spin heme binding site [chemical binding]; other site 381754010670 Putative water exit pathway; other site 381754010671 Binuclear center (active site) [active] 381754010672 Putative proton exit pathway; other site 381754010673 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 381754010674 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 381754010675 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 381754010676 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 381754010677 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 381754010678 Cytochrome c; Region: Cytochrom_C; cl11414 381754010679 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 381754010680 4Fe-4S binding domain; Region: Fer4_5; pfam12801 381754010681 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 381754010682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 381754010683 FixH; Region: FixH; pfam05751 381754010684 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 381754010685 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 381754010686 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381754010687 metal-binding site [ion binding] 381754010688 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381754010689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754010690 motif II; other site 381754010691 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 381754010692 Uncharacterized conserved protein [Function unknown]; Region: COG2836 381754010693 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 381754010694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754010695 FeS/SAM binding site; other site 381754010696 HemN C-terminal domain; Region: HemN_C; pfam06969 381754010697 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 381754010698 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 381754010699 ligand binding site [chemical binding]; other site 381754010700 flexible hinge region; other site 381754010701 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 381754010702 putative switch regulator; other site 381754010703 non-specific DNA interactions [nucleotide binding]; other site 381754010704 DNA binding site [nucleotide binding] 381754010705 sequence specific DNA binding site [nucleotide binding]; other site 381754010706 putative cAMP binding site [chemical binding]; other site 381754010707 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754010708 active site 381754010709 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 381754010710 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 381754010711 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 381754010712 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 381754010713 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 381754010714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754010715 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 381754010716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 381754010717 short chain dehydrogenase; Provisional; Region: PRK06181 381754010718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754010719 NAD(P) binding site [chemical binding]; other site 381754010720 active site 381754010721 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 381754010722 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754010723 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754010724 active site 381754010725 recombination protein RecR; Reviewed; Region: recR; PRK00076 381754010726 RecR protein; Region: RecR; pfam02132 381754010727 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 381754010728 putative active site [active] 381754010729 putative metal-binding site [ion binding]; other site 381754010730 tetramer interface [polypeptide binding]; other site 381754010731 hypothetical protein; Validated; Region: PRK00153 381754010732 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 381754010733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754010734 Walker A motif; other site 381754010735 ATP binding site [chemical binding]; other site 381754010736 Walker B motif; other site 381754010737 arginine finger; other site 381754010738 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 381754010739 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754010740 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754010741 substrate binding pocket [chemical binding]; other site 381754010742 membrane-bound complex binding site; other site 381754010743 hinge residues; other site 381754010744 Ligase N family; Region: LIGANc; smart00532 381754010745 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 381754010746 nucleotide binding pocket [chemical binding]; other site 381754010747 K-X-D-G motif; other site 381754010748 catalytic site [active] 381754010749 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 381754010750 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 381754010751 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 381754010752 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 381754010753 Dimer interface [polypeptide binding]; other site 381754010754 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 381754010755 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 381754010756 FtsZ protein binding site [polypeptide binding]; other site 381754010757 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 381754010758 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 381754010759 Walker A/P-loop; other site 381754010760 ATP binding site [chemical binding]; other site 381754010761 Q-loop/lid; other site 381754010762 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 381754010763 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 381754010764 ABC transporter signature motif; other site 381754010765 Walker B; other site 381754010766 D-loop; other site 381754010767 H-loop/switch region; other site 381754010768 Transcriptional regulators [Transcription]; Region: GntR; COG1802 381754010769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754010770 DNA-binding site [nucleotide binding]; DNA binding site 381754010771 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 381754010772 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 381754010773 Fatty acid desaturase; Region: FA_desaturase; pfam00487 381754010774 Di-iron ligands [ion binding]; other site 381754010775 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 381754010776 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754010777 catalytic loop [active] 381754010778 iron binding site [ion binding]; other site 381754010779 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 381754010780 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 381754010781 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 381754010782 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 381754010783 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754010784 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 381754010785 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 381754010786 XdhC Rossmann domain; Region: XdhC_C; pfam13478 381754010787 guanine deaminase; Provisional; Region: PRK09228 381754010788 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 381754010789 active site 381754010790 Transcriptional regulators [Transcription]; Region: GntR; COG1802 381754010791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754010792 DNA-binding site [nucleotide binding]; DNA binding site 381754010793 FCD domain; Region: FCD; pfam07729 381754010794 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 381754010795 Sulfate transporter family; Region: Sulfate_transp; pfam00916 381754010796 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 381754010797 active site 381754010798 homotetramer interface [polypeptide binding]; other site 381754010799 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 381754010800 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 381754010801 active site 381754010802 catalytic site [active] 381754010803 tetramer interface [polypeptide binding]; other site 381754010804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 381754010805 allantoicase; Provisional; Region: PRK13257 381754010806 Allantoicase repeat; Region: Allantoicase; pfam03561 381754010807 Allantoicase repeat; Region: Allantoicase; pfam03561 381754010808 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 381754010809 ureidoglycolate hydrolase; Provisional; Region: PRK03606 381754010810 Predicted membrane protein [Function unknown]; Region: COG3748 381754010811 Protein of unknown function (DUF989); Region: DUF989; pfam06181 381754010812 Cytochrome c; Region: Cytochrom_C; pfam00034 381754010813 xanthine permease; Region: pbuX; TIGR03173 381754010814 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 381754010815 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 381754010816 active site 381754010817 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 381754010818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754010819 FeS/SAM binding site; other site 381754010820 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 381754010821 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 381754010822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754010823 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 381754010824 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 381754010825 glyoxylate carboligase; Provisional; Region: PRK11269 381754010826 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 381754010827 PYR/PP interface [polypeptide binding]; other site 381754010828 dimer interface [polypeptide binding]; other site 381754010829 TPP binding site [chemical binding]; other site 381754010830 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754010831 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 381754010832 TPP-binding site [chemical binding]; other site 381754010833 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 381754010834 tartronate semialdehyde reductase; Provisional; Region: PRK15059 381754010835 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 381754010836 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 381754010837 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 381754010838 MOFRL family; Region: MOFRL; pfam05161 381754010839 pyruvate kinase; Provisional; Region: PRK06247 381754010840 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 381754010841 domain interfaces; other site 381754010842 active site 381754010843 Urea transporter; Region: UT; cl01829 381754010844 Ion transport protein; Region: Ion_trans; pfam00520 381754010845 Ion channel; Region: Ion_trans_2; pfam07885 381754010846 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 381754010847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 381754010848 conserved hypothetical protein; Region: TIGR02231 381754010849 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 381754010850 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 381754010851 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 381754010852 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 381754010853 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 381754010854 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 381754010855 homodimer interface [polypeptide binding]; other site 381754010856 homotetramer interface [polypeptide binding]; other site 381754010857 active site pocket [active] 381754010858 cleavage site 381754010859 Amino acid permease; Region: AA_permease_2; pfam13520 381754010860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754010861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754010862 DNA binding residues [nucleotide binding] 381754010863 dimerization interface [polypeptide binding]; other site 381754010864 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 381754010865 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 381754010866 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 381754010867 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 381754010868 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 381754010869 catalytic residues [active] 381754010870 central insert; other site 381754010871 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 381754010872 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 381754010873 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 381754010874 heme exporter protein CcmC; Region: ccmC; TIGR01191 381754010875 heme exporter protein CcmB; Region: ccmB; TIGR01190 381754010876 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 381754010877 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 381754010878 Walker A/P-loop; other site 381754010879 ATP binding site [chemical binding]; other site 381754010880 Q-loop/lid; other site 381754010881 ABC transporter signature motif; other site 381754010882 Walker B; other site 381754010883 D-loop; other site 381754010884 H-loop/switch region; other site 381754010885 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 381754010886 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 381754010887 short chain dehydrogenase; Provisional; Region: PRK12937 381754010888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754010889 NAD(P) binding site [chemical binding]; other site 381754010890 active site 381754010891 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 381754010892 Predicted transcriptional regulator [Transcription]; Region: COG2378 381754010893 HTH domain; Region: HTH_11; pfam08279 381754010894 WYL domain; Region: WYL; pfam13280 381754010895 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 381754010896 C-terminal domain interface [polypeptide binding]; other site 381754010897 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754010898 GSH binding site (G-site) [chemical binding]; other site 381754010899 dimer interface [polypeptide binding]; other site 381754010900 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 381754010901 N-terminal domain interface [polypeptide binding]; other site 381754010902 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 381754010903 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 381754010904 putative CheA interaction surface; other site 381754010905 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 381754010906 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 381754010907 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754010908 P-loop; other site 381754010909 Magnesium ion binding site [ion binding]; other site 381754010910 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754010911 Magnesium ion binding site [ion binding]; other site 381754010912 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 381754010913 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 381754010914 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754010915 ligand binding site [chemical binding]; other site 381754010916 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 381754010917 flagellar motor protein; Reviewed; Region: motC; PRK09109 381754010918 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 381754010919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754010920 active site 381754010921 phosphorylation site [posttranslational modification] 381754010922 intermolecular recognition site; other site 381754010923 dimerization interface [polypeptide binding]; other site 381754010924 CheB methylesterase; Region: CheB_methylest; pfam01339 381754010925 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754010926 putative binding surface; other site 381754010927 active site 381754010928 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 381754010929 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 381754010930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754010931 ATP binding site [chemical binding]; other site 381754010932 Mg2+ binding site [ion binding]; other site 381754010933 G-X-G motif; other site 381754010934 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 381754010935 Chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheZ; COG3143 381754010936 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 381754010937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754010938 active site 381754010939 phosphorylation site [posttranslational modification] 381754010940 intermolecular recognition site; other site 381754010941 dimerization interface [polypeptide binding]; other site 381754010942 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 381754010943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754010944 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 381754010945 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754010946 DNA binding residues [nucleotide binding] 381754010947 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 381754010948 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 381754010949 P-loop; other site 381754010950 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 381754010951 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381754010952 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 381754010953 FHIPEP family; Region: FHIPEP; pfam00771 381754010954 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 381754010955 Repair protein; Region: Repair_PSII; pfam04536 381754010956 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 381754010957 Repair protein; Region: Repair_PSII; pfam04536 381754010958 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 381754010959 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 381754010960 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 381754010961 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 381754010962 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 381754010963 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 381754010964 flagellar motor switch protein; Validated; Region: fliN; PRK05698 381754010965 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 381754010966 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 381754010967 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 381754010968 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 381754010969 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 381754010970 PAAR motif; Region: PAAR_motif; pfam05488 381754010971 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 381754010972 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 381754010973 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 381754010974 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 381754010975 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 381754010976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 381754010977 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 381754010978 HAMP domain; Region: HAMP; pfam00672 381754010979 dimerization interface [polypeptide binding]; other site 381754010980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754010981 dimer interface [polypeptide binding]; other site 381754010982 phosphorylation site [posttranslational modification] 381754010983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754010984 ATP binding site [chemical binding]; other site 381754010985 Mg2+ binding site [ion binding]; other site 381754010986 G-X-G motif; other site 381754010987 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 381754010988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754010989 active site 381754010990 phosphorylation site [posttranslational modification] 381754010991 intermolecular recognition site; other site 381754010992 dimerization interface [polypeptide binding]; other site 381754010993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754010994 DNA binding site [nucleotide binding] 381754010995 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 381754010996 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754010997 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754010998 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754010999 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 381754011000 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754011001 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754011002 metal binding site [ion binding]; metal-binding site 381754011003 active site 381754011004 I-site; other site 381754011005 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754011006 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 381754011007 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 381754011008 Autoinducer binding domain; Region: Autoind_bind; pfam03472 381754011009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754011010 DNA binding residues [nucleotide binding] 381754011011 dimerization interface [polypeptide binding]; other site 381754011012 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 381754011013 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 381754011014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381754011015 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 381754011016 Soluble P-type ATPase [General function prediction only]; Region: COG4087 381754011017 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 381754011018 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 381754011019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754011020 Coenzyme A binding pocket [chemical binding]; other site 381754011021 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 381754011022 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 381754011023 Sulfatase; Region: Sulfatase; pfam00884 381754011024 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 381754011025 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 381754011026 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 381754011027 iron-sulfur cluster [ion binding]; other site 381754011028 [2Fe-2S] cluster binding site [ion binding]; other site 381754011029 YciI-like protein; Reviewed; Region: PRK12863 381754011030 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 381754011031 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 381754011032 active site 381754011033 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 381754011034 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 381754011035 active site 381754011036 dimer interface [polypeptide binding]; other site 381754011037 metal binding site [ion binding]; metal-binding site 381754011038 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 381754011039 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 381754011040 NAD(P) binding site [chemical binding]; other site 381754011041 catalytic residues [active] 381754011042 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 381754011043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011045 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754011046 putative effector binding pocket; other site 381754011047 dimerization interface [polypeptide binding]; other site 381754011048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754011049 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 381754011050 Walker A/P-loop; other site 381754011051 ATP binding site [chemical binding]; other site 381754011052 Q-loop/lid; other site 381754011053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754011054 Q-loop/lid; other site 381754011055 ABC transporter signature motif; other site 381754011056 ABC transporter signature motif; other site 381754011057 Walker B; other site 381754011058 Walker B; other site 381754011059 D-loop; other site 381754011060 H-loop/switch region; other site 381754011061 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754011062 DTW domain; Region: DTW; cl01221 381754011063 PAS domain; Region: PAS_9; pfam13426 381754011064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754011065 putative active site [active] 381754011066 heme pocket [chemical binding]; other site 381754011067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754011068 PAS domain; Region: PAS_9; pfam13426 381754011069 putative active site [active] 381754011070 heme pocket [chemical binding]; other site 381754011071 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754011072 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754011073 dimer interface [polypeptide binding]; other site 381754011074 putative CheW interface [polypeptide binding]; other site 381754011075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754011078 dimerization interface [polypeptide binding]; other site 381754011079 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 381754011080 agmatinase; Region: agmatinase; TIGR01230 381754011081 oligomer interface [polypeptide binding]; other site 381754011082 putative active site [active] 381754011083 Mn binding site [ion binding]; other site 381754011084 SnoaL-like domain; Region: SnoaL_3; pfam13474 381754011085 SnoaL-like domain; Region: SnoaL_2; pfam12680 381754011086 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 381754011087 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 381754011088 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 381754011089 Na binding site [ion binding]; other site 381754011090 hypothetical protein; Provisional; Region: PRK07524 381754011091 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 381754011092 PYR/PP interface [polypeptide binding]; other site 381754011093 dimer interface [polypeptide binding]; other site 381754011094 TPP binding site [chemical binding]; other site 381754011095 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754011096 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 381754011097 TPP-binding site [chemical binding]; other site 381754011098 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 381754011099 FAD binding domain; Region: FAD_binding_4; pfam01565 381754011100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381754011101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011103 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 381754011104 putative dimerization interface [polypeptide binding]; other site 381754011105 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 381754011106 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 381754011107 EamA-like transporter family; Region: EamA; pfam00892 381754011108 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 381754011109 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 381754011110 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 381754011111 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 381754011112 active site 381754011113 Zn binding site [ion binding]; other site 381754011114 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 381754011115 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 381754011116 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381754011117 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 381754011118 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 381754011119 active site 381754011120 NTP binding site [chemical binding]; other site 381754011121 metal binding triad [ion binding]; metal-binding site 381754011122 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 381754011123 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754011124 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 381754011125 Family description; Region: UvrD_C_2; pfam13538 381754011126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754011127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754011128 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 381754011129 Methyltransferase domain; Region: Methyltransf_24; pfam13578 381754011130 Predicted ester cyclase [General function prediction only]; Region: COG5485 381754011131 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 381754011132 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 381754011133 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754011134 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 381754011135 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 381754011136 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 381754011137 carboxyltransferase (CT) interaction site; other site 381754011138 biotinylation site [posttranslational modification]; other site 381754011139 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 381754011140 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 381754011141 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011143 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 381754011144 substrate binding pocket [chemical binding]; other site 381754011145 dimerization interface [polypeptide binding]; other site 381754011146 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 381754011147 active site flap/lid [active] 381754011148 nucleophilic elbow; other site 381754011149 catalytic triad [active] 381754011150 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 381754011151 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 381754011152 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 381754011153 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 381754011154 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 381754011155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754011156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754011157 active site 381754011158 phosphorylation site [posttranslational modification] 381754011159 intermolecular recognition site; other site 381754011160 dimerization interface [polypeptide binding]; other site 381754011161 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754011162 DNA binding residues [nucleotide binding] 381754011163 dimerization interface [polypeptide binding]; other site 381754011164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754011165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754011166 dimer interface [polypeptide binding]; other site 381754011167 phosphorylation site [posttranslational modification] 381754011168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754011169 ATP binding site [chemical binding]; other site 381754011170 Mg2+ binding site [ion binding]; other site 381754011171 G-X-G motif; other site 381754011172 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381754011173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754011174 active site 381754011175 phosphorylation site [posttranslational modification] 381754011176 intermolecular recognition site; other site 381754011177 dimerization interface [polypeptide binding]; other site 381754011178 Methyltransferase domain; Region: Methyltransf_23; pfam13489 381754011179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754011180 S-adenosylmethionine binding site [chemical binding]; other site 381754011181 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 381754011182 nudix motif; other site 381754011183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754011184 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 381754011185 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 381754011186 SnoaL-like domain; Region: SnoaL_2; pfam12680 381754011187 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 381754011188 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 381754011189 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 381754011190 RHS Repeat; Region: RHS_repeat; pfam05593 381754011191 RHS Repeat; Region: RHS_repeat; pfam05593 381754011192 RHS Repeat; Region: RHS_repeat; pfam05593 381754011193 RHS Repeat; Region: RHS_repeat; pfam05593 381754011194 RHS Repeat; Region: RHS_repeat; cl11982 381754011195 RHS protein; Region: RHS; pfam03527 381754011196 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 381754011197 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 381754011198 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 381754011199 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 381754011200 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 381754011201 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 381754011202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754011203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754011204 active site 381754011205 phosphorylation site [posttranslational modification] 381754011206 intermolecular recognition site; other site 381754011207 dimerization interface [polypeptide binding]; other site 381754011208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754011209 DNA binding site [nucleotide binding] 381754011210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754011211 phosphorylation site [posttranslational modification] 381754011212 dimer interface [polypeptide binding]; other site 381754011213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754011214 ATP binding site [chemical binding]; other site 381754011215 Mg2+ binding site [ion binding]; other site 381754011216 G-X-G motif; other site 381754011217 outer membrane receptor FepA; Provisional; Region: PRK13524 381754011218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754011219 N-terminal plug; other site 381754011220 ligand-binding site [chemical binding]; other site 381754011221 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 381754011222 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 381754011223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754011224 Predicted transcriptional regulator [Transcription]; Region: COG1959 381754011225 Transcriptional regulator; Region: Rrf2; pfam02082 381754011226 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 381754011227 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 381754011228 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 381754011229 catalytic residues [active] 381754011230 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 381754011231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754011232 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754011233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754011234 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 381754011235 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 381754011236 Isochorismatase family; Region: Isochorismatase; pfam00857 381754011237 catalytic triad [active] 381754011238 dimer interface [polypeptide binding]; other site 381754011239 conserved cis-peptide bond; other site 381754011240 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 381754011241 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 381754011242 active site 381754011243 outer membrane porin, OprD family; Region: OprD; pfam03573 381754011244 Transmembrane secretion effector; Region: MFS_3; pfam05977 381754011245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754011246 putative substrate translocation pore; other site 381754011247 Tse2 immunity protein Tsi2 and similar proteins; Region: Tsi2_like; cd11690 381754011248 dimer interface [polypeptide binding]; other site 381754011249 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754011250 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754011251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 381754011252 Uncharacterized conserved protein [Function unknown]; Region: COG3791 381754011253 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 381754011254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754011255 Walker A motif; other site 381754011256 ATP binding site [chemical binding]; other site 381754011257 Walker B motif; other site 381754011258 arginine finger; other site 381754011259 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 381754011260 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 381754011261 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 381754011262 dimer interface [polypeptide binding]; other site 381754011263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754011264 catalytic residue [active] 381754011265 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754011266 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 381754011267 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754011268 EamA-like transporter family; Region: EamA; pfam00892 381754011269 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 381754011270 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 381754011271 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 381754011272 putative molybdopterin cofactor binding site; other site 381754011273 Ferredoxin [Energy production and conversion]; Region: COG1146 381754011274 4Fe-4S binding domain; Region: Fer4; cl02805 381754011275 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 381754011276 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 381754011277 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 381754011278 putative active site [active] 381754011279 putative FMN binding site [chemical binding]; other site 381754011280 putative substrate binding site [chemical binding]; other site 381754011281 putative catalytic residue [active] 381754011282 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754011283 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754011284 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381754011285 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 381754011286 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 381754011287 DNA binding residues [nucleotide binding] 381754011288 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 381754011289 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 381754011290 potential catalytic triad [active] 381754011291 conserved cys residue [active] 381754011292 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 381754011293 dimer interface [polypeptide binding]; other site 381754011294 Uncharacterized conserved protein [Function unknown]; Region: COG3791 381754011295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754011296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754011297 enoyl-CoA hydratase; Provisional; Region: PRK12478 381754011298 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754011299 substrate binding site [chemical binding]; other site 381754011300 oxyanion hole (OAH) forming residues; other site 381754011301 trimer interface [polypeptide binding]; other site 381754011302 AMP-binding domain protein; Validated; Region: PRK07529 381754011303 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754011304 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 381754011305 acyl-activating enzyme (AAE) consensus motif; other site 381754011306 putative AMP binding site [chemical binding]; other site 381754011307 putative active site [active] 381754011308 putative CoA binding site [chemical binding]; other site 381754011309 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 381754011310 putative acetyltransferase YhhY; Provisional; Region: PRK10140 381754011311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754011312 Coenzyme A binding pocket [chemical binding]; other site 381754011313 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 381754011314 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 381754011315 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 381754011316 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 381754011317 ligand binding site [chemical binding]; other site 381754011318 NAD binding site [chemical binding]; other site 381754011319 catalytic site [active] 381754011320 homodimer interface [polypeptide binding]; other site 381754011321 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 381754011322 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 381754011323 Outer membrane efflux protein; Region: OEP; pfam02321 381754011324 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 381754011325 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754011326 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 381754011327 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 381754011328 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 381754011329 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 381754011330 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754011331 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 381754011332 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754011333 N-terminal plug; other site 381754011334 ligand-binding site [chemical binding]; other site 381754011335 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754011336 FecR protein; Region: FecR; pfam04773 381754011337 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 381754011338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754011339 DNA binding residues [nucleotide binding] 381754011340 multidrug efflux protein; Reviewed; Region: PRK01766 381754011341 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 381754011342 cation binding site [ion binding]; other site 381754011343 threonine and homoserine efflux system; Provisional; Region: PRK10532 381754011344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754011345 non-specific DNA binding site [nucleotide binding]; other site 381754011346 salt bridge; other site 381754011347 sequence-specific DNA binding site [nucleotide binding]; other site 381754011348 Cupin domain; Region: Cupin_2; pfam07883 381754011349 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 381754011350 dimer interface [polypeptide binding]; other site 381754011351 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 381754011352 putative deacylase active site [active] 381754011353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 381754011354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754011355 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 381754011356 dimer interface [polypeptide binding]; other site 381754011357 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 381754011358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754011359 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 381754011360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 381754011361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 381754011362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754011363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754011364 DNA binding residues [nucleotide binding] 381754011365 dimerization interface [polypeptide binding]; other site 381754011366 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 381754011367 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 381754011368 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 381754011369 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754011370 short chain dehydrogenase; Provisional; Region: PRK06523 381754011371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754011372 NAD(P) binding site [chemical binding]; other site 381754011373 active site 381754011374 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 381754011375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754011376 substrate binding pocket [chemical binding]; other site 381754011377 membrane-bound complex binding site; other site 381754011378 hinge residues; other site 381754011379 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381754011380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754011381 dimer interface [polypeptide binding]; other site 381754011382 conserved gate region; other site 381754011383 putative PBP binding loops; other site 381754011384 ABC-ATPase subunit interface; other site 381754011385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754011386 dimer interface [polypeptide binding]; other site 381754011387 conserved gate region; other site 381754011388 putative PBP binding loops; other site 381754011389 ABC-ATPase subunit interface; other site 381754011390 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 381754011391 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 381754011392 Walker A/P-loop; other site 381754011393 ATP binding site [chemical binding]; other site 381754011394 Q-loop/lid; other site 381754011395 ABC transporter signature motif; other site 381754011396 Walker B; other site 381754011397 D-loop; other site 381754011398 H-loop/switch region; other site 381754011399 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 381754011400 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 381754011401 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 381754011402 homodimer interface [polypeptide binding]; other site 381754011403 active site 381754011404 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 381754011405 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 381754011406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754011407 dimer interface [polypeptide binding]; other site 381754011408 phosphorylation site [posttranslational modification] 381754011409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754011410 ATP binding site [chemical binding]; other site 381754011411 Mg2+ binding site [ion binding]; other site 381754011412 G-X-G motif; other site 381754011413 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754011414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754011415 active site 381754011416 phosphorylation site [posttranslational modification] 381754011417 intermolecular recognition site; other site 381754011418 dimerization interface [polypeptide binding]; other site 381754011419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754011420 Walker A motif; other site 381754011421 ATP binding site [chemical binding]; other site 381754011422 Walker B motif; other site 381754011423 arginine finger; other site 381754011424 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754011425 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 381754011426 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 381754011427 FMN binding site [chemical binding]; other site 381754011428 active site 381754011429 substrate binding site [chemical binding]; other site 381754011430 catalytic residue [active] 381754011431 Methyltransferase domain; Region: Methyltransf_23; pfam13489 381754011432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754011433 S-adenosylmethionine binding site [chemical binding]; other site 381754011434 Peptidase of plants and bacteria; Region: BSP; pfam04450 381754011435 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 381754011436 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 381754011437 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 381754011438 Transporter associated domain; Region: CorC_HlyC; smart01091 381754011439 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 381754011440 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 381754011441 aromatic chitin/cellulose binding site residues [chemical binding]; other site 381754011442 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 381754011443 aromatic chitin/cellulose binding site residues [chemical binding]; other site 381754011444 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582 381754011445 active site 381754011446 short chain dehydrogenase; Provisional; Region: PRK09291 381754011447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754011448 NAD(P) binding site [chemical binding]; other site 381754011449 active site 381754011450 Domain of unknown function (DUF336); Region: DUF336; cl01249 381754011451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754011454 dimerization interface [polypeptide binding]; other site 381754011455 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 381754011456 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 381754011457 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 381754011458 active site 381754011459 substrate binding site [chemical binding]; other site 381754011460 Mg2+ binding site [ion binding]; other site 381754011461 threonine dehydratase; Reviewed; Region: PRK09224 381754011462 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 381754011463 tetramer interface [polypeptide binding]; other site 381754011464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754011465 catalytic residue [active] 381754011466 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 381754011467 putative Ile/Val binding site [chemical binding]; other site 381754011468 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 381754011469 putative Ile/Val binding site [chemical binding]; other site 381754011470 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 381754011471 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 381754011472 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 381754011473 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 381754011474 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754011475 N-terminal plug; other site 381754011476 ligand-binding site [chemical binding]; other site 381754011477 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 381754011478 UbiA prenyltransferase family; Region: UbiA; pfam01040 381754011479 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 381754011480 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 381754011481 Subunit I/III interface [polypeptide binding]; other site 381754011482 Subunit III/IV interface [polypeptide binding]; other site 381754011483 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 381754011484 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 381754011485 D-pathway; other site 381754011486 Putative ubiquinol binding site [chemical binding]; other site 381754011487 Low-spin heme (heme b) binding site [chemical binding]; other site 381754011488 Putative water exit pathway; other site 381754011489 Binuclear center (heme o3/CuB) [ion binding]; other site 381754011490 K-pathway; other site 381754011491 Putative proton exit pathway; other site 381754011492 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 381754011493 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 381754011494 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 381754011495 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 381754011496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754011497 putative substrate translocation pore; other site 381754011498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754011499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754011500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 381754011501 PUCC protein; Region: PUCC; pfam03209 381754011502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754011504 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 381754011505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754011506 motif II; other site 381754011507 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 381754011508 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754011509 catalytic residue [active] 381754011510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011511 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 381754011512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754011513 dimerization interface [polypeptide binding]; other site 381754011514 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 381754011515 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 381754011516 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 381754011517 putative active site [active] 381754011518 putative dimer interface [polypeptide binding]; other site 381754011519 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 381754011520 nucleotide binding site/active site [active] 381754011521 HIT family signature motif; other site 381754011522 catalytic residue [active] 381754011523 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 381754011524 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381754011525 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 381754011526 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 381754011527 Catalytic site [active] 381754011528 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754011529 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 381754011530 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754011531 N-terminal plug; other site 381754011532 ligand-binding site [chemical binding]; other site 381754011533 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754011534 FecR protein; Region: FecR; pfam04773 381754011535 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 381754011536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754011537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754011538 DNA binding residues [nucleotide binding] 381754011539 hypothetical protein; Provisional; Region: PRK05170 381754011540 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 381754011541 putative metal binding site [ion binding]; other site 381754011542 putative homodimer interface [polypeptide binding]; other site 381754011543 putative homotetramer interface [polypeptide binding]; other site 381754011544 putative homodimer-homodimer interface [polypeptide binding]; other site 381754011545 putative allosteric switch controlling residues; other site 381754011546 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 381754011547 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 381754011548 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 381754011549 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 381754011550 NAD binding site [chemical binding]; other site 381754011551 ligand binding site [chemical binding]; other site 381754011552 catalytic site [active] 381754011553 YcgL domain; Region: YcgL; pfam05166 381754011554 ribonuclease D; Region: rnd; TIGR01388 381754011555 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 381754011556 catalytic site [active] 381754011557 putative active site [active] 381754011558 putative substrate binding site [chemical binding]; other site 381754011559 HRDC domain; Region: HRDC; pfam00570 381754011560 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 381754011561 Strictosidine synthase; Region: Str_synth; pfam03088 381754011562 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 381754011563 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 381754011564 active site residue [active] 381754011565 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 381754011566 active site residue [active] 381754011567 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 381754011568 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 381754011569 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 381754011570 catalytic residues [active] 381754011571 dimer interface [polypeptide binding]; other site 381754011572 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754011573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754011574 Transcriptional regulators [Transcription]; Region: MarR; COG1846 381754011575 MarR family; Region: MarR_2; pfam12802 381754011576 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 381754011577 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 381754011578 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754011579 active site 381754011580 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 381754011581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754011582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754011583 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 381754011584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754011585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754011586 cobalamin synthase; Reviewed; Region: cobS; PRK00235 381754011587 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 381754011588 catalytic core [active] 381754011589 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 381754011590 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 381754011591 putative dimer interface [polypeptide binding]; other site 381754011592 active site pocket [active] 381754011593 putative cataytic base [active] 381754011594 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 381754011595 homotrimer interface [polypeptide binding]; other site 381754011596 Walker A motif; other site 381754011597 GTP binding site [chemical binding]; other site 381754011598 Walker B motif; other site 381754011599 cobyric acid synthase; Provisional; Region: PRK00784 381754011600 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 381754011601 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 381754011602 catalytic triad [active] 381754011603 threonine-phosphate decarboxylase; Reviewed; Region: PRK05664 381754011604 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 381754011605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754011606 catalytic residue [active] 381754011607 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 381754011608 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 381754011609 FMN binding site [chemical binding]; other site 381754011610 dimer interface [polypeptide binding]; other site 381754011611 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 381754011612 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 381754011613 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 381754011614 conserved cys residue [active] 381754011615 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 381754011616 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 381754011617 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 381754011618 homodimer interface [polypeptide binding]; other site 381754011619 Walker A motif; other site 381754011620 ATP binding site [chemical binding]; other site 381754011621 hydroxycobalamin binding site [chemical binding]; other site 381754011622 Walker B motif; other site 381754011623 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 381754011624 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754011625 N-terminal plug; other site 381754011626 ligand-binding site [chemical binding]; other site 381754011627 Fusaric acid resistance protein family; Region: FUSC; pfam04632 381754011628 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 381754011629 Transcriptional regulators [Transcription]; Region: GntR; COG1802 381754011630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754011631 DNA-binding site [nucleotide binding]; DNA binding site 381754011632 FCD domain; Region: FCD; pfam07729 381754011633 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 381754011634 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 381754011635 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 381754011636 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 381754011637 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 381754011638 EamA-like transporter family; Region: EamA; pfam00892 381754011639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011641 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754011642 dimerization interface [polypeptide binding]; other site 381754011643 Helix-turn-helix domain; Region: HTH_31; pfam13560 381754011644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754011645 PAS fold; Region: PAS_4; pfam08448 381754011646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754011647 putative active site [active] 381754011648 heme pocket [chemical binding]; other site 381754011649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754011650 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754011651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754011652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754011653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754011654 substrate binding pocket [chemical binding]; other site 381754011655 membrane-bound complex binding site; other site 381754011656 hinge residues; other site 381754011657 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 381754011658 substrate binding site [chemical binding]; other site 381754011659 Protein of unknown function (DUF521); Region: DUF521; pfam04412 381754011660 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 381754011661 substrate binding site [chemical binding]; other site 381754011662 ligand binding site [chemical binding]; other site 381754011663 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381754011664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754011665 dimer interface [polypeptide binding]; other site 381754011666 conserved gate region; other site 381754011667 putative PBP binding loops; other site 381754011668 ABC-ATPase subunit interface; other site 381754011669 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381754011670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754011671 dimer interface [polypeptide binding]; other site 381754011672 conserved gate region; other site 381754011673 putative PBP binding loops; other site 381754011674 ABC-ATPase subunit interface; other site 381754011675 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 381754011676 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 381754011677 Walker A/P-loop; other site 381754011678 ATP binding site [chemical binding]; other site 381754011679 Q-loop/lid; other site 381754011680 ABC transporter signature motif; other site 381754011681 Walker B; other site 381754011682 D-loop; other site 381754011683 H-loop/switch region; other site 381754011684 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 381754011685 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 381754011686 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 381754011687 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 381754011688 inhibitor site; inhibition site 381754011689 active site 381754011690 dimer interface [polypeptide binding]; other site 381754011691 catalytic residue [active] 381754011692 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 381754011693 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 381754011694 dimer interface [polypeptide binding]; other site 381754011695 NADP binding site [chemical binding]; other site 381754011696 catalytic residues [active] 381754011697 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 381754011698 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 381754011699 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 381754011700 dimerization interface [polypeptide binding]; other site 381754011701 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754011702 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754011703 dimer interface [polypeptide binding]; other site 381754011704 putative CheW interface [polypeptide binding]; other site 381754011705 Protease inhibitor Inh; Region: Inh; pfam02974 381754011706 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 381754011707 active site 381754011708 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 381754011709 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 381754011710 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 381754011711 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754011712 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754011713 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 381754011714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754011715 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 381754011716 Walker A/P-loop; other site 381754011717 ATP binding site [chemical binding]; other site 381754011718 Q-loop/lid; other site 381754011719 ABC transporter signature motif; other site 381754011720 Walker B; other site 381754011721 D-loop; other site 381754011722 H-loop/switch region; other site 381754011723 outer membrane porin, OprD family; Region: OprD; pfam03573 381754011724 citrate-proton symporter; Provisional; Region: PRK15075 381754011725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754011726 putative substrate translocation pore; other site 381754011727 PAS fold; Region: PAS_4; pfam08448 381754011728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754011729 dimer interface [polypeptide binding]; other site 381754011730 phosphorylation site [posttranslational modification] 381754011731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754011732 ATP binding site [chemical binding]; other site 381754011733 Mg2+ binding site [ion binding]; other site 381754011734 G-X-G motif; other site 381754011735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754011736 active site 381754011737 phosphorylation site [posttranslational modification] 381754011738 intermolecular recognition site; other site 381754011739 dimerization interface [polypeptide binding]; other site 381754011740 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 381754011741 active site 381754011742 catalytic residues [active] 381754011743 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 381754011744 Fusaric acid resistance protein family; Region: FUSC; pfam04632 381754011745 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 381754011746 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754011747 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754011748 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754011749 Phosphotransferase enzyme family; Region: APH; pfam01636 381754011750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754011751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754011752 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 381754011753 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754011754 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 381754011755 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754011756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011758 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 381754011759 putative substrate binding pocket [chemical binding]; other site 381754011760 putative dimerization interface [polypeptide binding]; other site 381754011761 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 381754011762 MltA specific insert domain; Region: MltA; pfam03562 381754011763 3D domain; Region: 3D; pfam06725 381754011764 Pirin-related protein [General function prediction only]; Region: COG1741 381754011765 Pirin; Region: Pirin; pfam02678 381754011766 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 381754011767 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 381754011768 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 381754011769 active site residue [active] 381754011770 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 381754011771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 381754011772 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 381754011773 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 381754011774 TrkA-N domain; Region: TrkA_N; pfam02254 381754011775 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 381754011776 putative hydrophobic ligand binding site [chemical binding]; other site 381754011777 Pirin-related protein [General function prediction only]; Region: COG1741 381754011778 Pirin; Region: Pirin; pfam02678 381754011779 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 381754011780 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754011781 Predicted flavoprotein [General function prediction only]; Region: COG0431 381754011782 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 381754011783 Isochorismatase family; Region: Isochorismatase; pfam00857 381754011784 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 381754011785 catalytic triad [active] 381754011786 dimer interface [polypeptide binding]; other site 381754011787 conserved cis-peptide bond; other site 381754011788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011790 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754011791 putative effector binding pocket; other site 381754011792 dimerization interface [polypeptide binding]; other site 381754011793 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 381754011794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754011795 S-adenosylmethionine binding site [chemical binding]; other site 381754011796 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 381754011797 NlpC/P60 family; Region: NLPC_P60; pfam00877 381754011798 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 381754011799 NlpC/P60 family; Region: NLPC_P60; pfam00877 381754011800 NAD-dependent deacetylase; Provisional; Region: PRK00481 381754011801 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 381754011802 NAD+ binding site [chemical binding]; other site 381754011803 substrate binding site [chemical binding]; other site 381754011804 Zn binding site [ion binding]; other site 381754011805 PAS domain; Region: PAS; smart00091 381754011806 PAS fold; Region: PAS_4; pfam08448 381754011807 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 381754011808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754011809 Walker A motif; other site 381754011810 ATP binding site [chemical binding]; other site 381754011811 Walker B motif; other site 381754011812 arginine finger; other site 381754011813 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 381754011814 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 381754011815 Amidinotransferase; Region: Amidinotransf; cl12043 381754011816 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 381754011817 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 381754011818 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 381754011819 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 381754011820 Ligand Binding Site [chemical binding]; other site 381754011821 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 381754011822 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 381754011823 DNA-J related protein; Region: DNAJ_related; pfam12339 381754011824 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 381754011825 HSP70 interaction site [polypeptide binding]; other site 381754011826 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 381754011827 hypothetical protein; Provisional; Region: PRK04860 381754011828 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 381754011829 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 381754011830 CoA-transferase family III; Region: CoA_transf_3; pfam02515 381754011831 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754011832 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754011833 active site 381754011834 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 381754011835 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 381754011836 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754011837 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 381754011838 C-terminal domain interface [polypeptide binding]; other site 381754011839 GSH binding site (G-site) [chemical binding]; other site 381754011840 dimer interface [polypeptide binding]; other site 381754011841 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 381754011842 dimer interface [polypeptide binding]; other site 381754011843 N-terminal domain interface [polypeptide binding]; other site 381754011844 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754011845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011846 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 381754011847 dimerization interface [polypeptide binding]; other site 381754011848 substrate binding pocket [chemical binding]; other site 381754011849 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 381754011850 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 381754011851 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754011852 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754011853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754011854 putative diguanylate cyclase; Provisional; Region: PRK09776 381754011855 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 381754011856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754011857 putative active site [active] 381754011858 heme pocket [chemical binding]; other site 381754011859 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754011860 putative active site [active] 381754011861 heme pocket [chemical binding]; other site 381754011862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754011863 putative active site [active] 381754011864 heme pocket [chemical binding]; other site 381754011865 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754011866 metal binding site [ion binding]; metal-binding site 381754011867 active site 381754011868 I-site; other site 381754011869 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754011870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754011871 dimer interface [polypeptide binding]; other site 381754011872 phosphorylation site [posttranslational modification] 381754011873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754011874 ATP binding site [chemical binding]; other site 381754011875 G-X-G motif; other site 381754011876 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 381754011877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754011878 active site 381754011879 phosphorylation site [posttranslational modification] 381754011880 intermolecular recognition site; other site 381754011881 dimerization interface [polypeptide binding]; other site 381754011882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754011883 DNA binding site [nucleotide binding] 381754011884 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 381754011885 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 381754011886 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 381754011887 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 381754011888 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 381754011889 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 381754011890 [4Fe-4S] binding site [ion binding]; other site 381754011891 molybdopterin cofactor binding site; other site 381754011892 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 381754011893 molybdopterin cofactor binding site; other site 381754011894 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 381754011895 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 381754011896 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 381754011897 Transglycosylase SLT domain; Region: SLT_2; pfam13406 381754011898 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754011899 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754011900 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 381754011901 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 381754011902 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 381754011903 Lipoxygenase; Region: Lipoxygenase; pfam00305 381754011904 Alginate lyase; Region: Alginate_lyase2; pfam08787 381754011905 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 381754011906 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 381754011907 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 381754011908 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 381754011909 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 381754011910 putative ATP binding site [chemical binding]; other site 381754011911 putative substrate interface [chemical binding]; other site 381754011912 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 381754011913 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 381754011914 metal binding site [ion binding]; metal-binding site 381754011915 dimer interface [polypeptide binding]; other site 381754011916 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 381754011917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754011918 S-adenosylmethionine binding site [chemical binding]; other site 381754011919 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 381754011920 DNA-binding site [nucleotide binding]; DNA binding site 381754011921 RNA-binding motif; other site 381754011922 sensor protein RstB; Provisional; Region: PRK10604 381754011923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754011924 dimerization interface [polypeptide binding]; other site 381754011925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754011926 dimer interface [polypeptide binding]; other site 381754011927 phosphorylation site [posttranslational modification] 381754011928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754011929 ATP binding site [chemical binding]; other site 381754011930 Mg2+ binding site [ion binding]; other site 381754011931 G-X-G motif; other site 381754011932 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 381754011933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754011934 active site 381754011935 phosphorylation site [posttranslational modification] 381754011936 intermolecular recognition site; other site 381754011937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754011938 DNA binding site [nucleotide binding] 381754011939 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 381754011940 ATP cone domain; Region: ATP-cone; pfam03477 381754011941 ATP cone domain; Region: ATP-cone; pfam03477 381754011942 Class I ribonucleotide reductase; Region: RNR_I; cd01679 381754011943 active site 381754011944 dimer interface [polypeptide binding]; other site 381754011945 catalytic residues [active] 381754011946 effector binding site; other site 381754011947 R2 peptide binding site; other site 381754011948 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 381754011949 dimer interface [polypeptide binding]; other site 381754011950 putative radical transfer pathway; other site 381754011951 diiron center [ion binding]; other site 381754011952 tyrosyl radical; other site 381754011953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 381754011954 BRO family, N-terminal domain; Region: Bro-N; cl10591 381754011955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381754011956 Transposase; Region: HTH_Tnp_1; pfam01527 381754011957 HTH-like domain; Region: HTH_21; pfam13276 381754011958 Integrase core domain; Region: rve; pfam00665 381754011959 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381754011960 Integrase core domain; Region: rve_3; pfam13683 381754011961 Prophage antirepressor [Transcription]; Region: COG3617 381754011962 Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042 381754011963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754011964 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 381754011965 putative substrate translocation pore; other site 381754011966 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 381754011967 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 381754011968 transcriptional regulator protein; Region: phnR; TIGR03337 381754011969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754011970 DNA-binding site [nucleotide binding]; DNA binding site 381754011971 UTRA domain; Region: UTRA; pfam07702 381754011972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754011975 dimerization interface [polypeptide binding]; other site 381754011976 hypothetical protein; Provisional; Region: PRK11171 381754011977 Cupin domain; Region: Cupin_2; pfam07883 381754011978 Cupin domain; Region: Cupin_2; pfam07883 381754011979 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 381754011980 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 381754011981 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 381754011982 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 381754011983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754011984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754011985 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 381754011986 putative effector binding pocket; other site 381754011987 putative dimerization interface [polypeptide binding]; other site 381754011988 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 381754011989 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 381754011990 active site 381754011991 catalytic tetrad [active] 381754011992 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 381754011993 NAD-dependent deacetylase; Provisional; Region: PRK00481 381754011994 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 381754011995 NAD+ binding site [chemical binding]; other site 381754011996 substrate binding site [chemical binding]; other site 381754011997 Zn binding site [ion binding]; other site 381754011998 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 381754011999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754012000 Zn2+ binding site [ion binding]; other site 381754012001 Mg2+ binding site [ion binding]; other site 381754012002 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 381754012003 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 381754012004 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 381754012005 active site 381754012006 catalytic residues [active] 381754012007 metal binding site [ion binding]; metal-binding site 381754012008 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 381754012009 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 381754012010 HAMP domain; Region: HAMP; pfam00672 381754012011 dimerization interface [polypeptide binding]; other site 381754012012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754012013 metal binding site [ion binding]; metal-binding site 381754012014 active site 381754012015 I-site; other site 381754012016 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754012017 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754012018 ligand binding site [chemical binding]; other site 381754012019 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 381754012020 S1 domain; Region: S1_2; pfam13509 381754012021 S1 domain; Region: S1_2; pfam13509 381754012022 Sulfatase; Region: Sulfatase; pfam00884 381754012023 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 381754012024 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 381754012025 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 381754012026 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754012027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754012028 Walker A/P-loop; other site 381754012029 ATP binding site [chemical binding]; other site 381754012030 Q-loop/lid; other site 381754012031 ABC transporter signature motif; other site 381754012032 Walker B; other site 381754012033 D-loop; other site 381754012034 H-loop/switch region; other site 381754012035 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 381754012036 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 381754012037 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 381754012038 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 381754012039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381754012040 RNA binding surface [nucleotide binding]; other site 381754012041 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 381754012042 active site 381754012043 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754012044 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754012045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754012046 putative substrate translocation pore; other site 381754012047 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 381754012048 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 381754012049 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 381754012050 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 381754012051 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 381754012052 Walker A motif/ATP binding site; other site 381754012053 Walker B motif; other site 381754012054 flagellar assembly protein H; Validated; Region: fliH; PRK05687 381754012055 Flagellar assembly protein FliH; Region: FliH; pfam02108 381754012056 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 381754012057 MgtE intracellular N domain; Region: MgtE_N; smart00924 381754012058 FliG C-terminal domain; Region: FliG_C; pfam01706 381754012059 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 381754012060 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 381754012061 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 381754012062 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 381754012063 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754012064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754012065 active site 381754012066 phosphorylation site [posttranslational modification] 381754012067 intermolecular recognition site; other site 381754012068 dimerization interface [polypeptide binding]; other site 381754012069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754012070 Walker A motif; other site 381754012071 ATP binding site [chemical binding]; other site 381754012072 Walker B motif; other site 381754012073 arginine finger; other site 381754012074 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754012075 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754012076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754012077 dimer interface [polypeptide binding]; other site 381754012078 phosphorylation site [posttranslational modification] 381754012079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754012080 ATP binding site [chemical binding]; other site 381754012081 Mg2+ binding site [ion binding]; other site 381754012082 G-X-G motif; other site 381754012083 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754012084 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 381754012085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754012086 Walker A motif; other site 381754012087 ATP binding site [chemical binding]; other site 381754012088 Walker B motif; other site 381754012089 arginine finger; other site 381754012090 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754012091 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 381754012092 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 381754012093 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 381754012094 FlaG protein; Region: FlaG; pfam03646 381754012095 flagellin; Reviewed; Region: PRK08869 381754012096 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 381754012097 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 381754012098 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 381754012099 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 381754012100 active site 381754012101 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 381754012102 active site 381754012103 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 381754012104 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 381754012105 putative trimer interface [polypeptide binding]; other site 381754012106 putative CoA binding site [chemical binding]; other site 381754012107 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 381754012108 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 381754012109 [2Fe-2S] cluster binding site [ion binding]; other site 381754012110 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 381754012111 alpha subunit interface [polypeptide binding]; other site 381754012112 active site 381754012113 substrate binding site [chemical binding]; other site 381754012114 Fe binding site [ion binding]; other site 381754012115 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 381754012116 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 381754012117 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 381754012118 putative trimer interface [polypeptide binding]; other site 381754012119 putative CoA binding site [chemical binding]; other site 381754012120 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 381754012121 classical (c) SDRs; Region: SDR_c; cd05233 381754012122 NAD(P) binding site [chemical binding]; other site 381754012123 active site 381754012124 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 381754012125 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 381754012126 dimer interface [polypeptide binding]; other site 381754012127 active site 381754012128 CoA binding pocket [chemical binding]; other site 381754012129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 381754012130 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 381754012131 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 381754012132 inhibitor-cofactor binding pocket; inhibition site 381754012133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754012134 catalytic residue [active] 381754012135 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 381754012136 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 381754012137 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 381754012138 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 381754012139 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 381754012140 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 381754012141 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 381754012142 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 381754012143 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 381754012144 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 381754012145 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 381754012146 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 381754012147 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 381754012148 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 381754012149 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 381754012150 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 381754012151 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 381754012152 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 381754012153 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 381754012154 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 381754012155 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 381754012156 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 381754012157 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 381754012158 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 381754012159 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 381754012160 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 381754012161 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 381754012162 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 381754012163 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 381754012164 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 381754012165 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 381754012166 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 381754012167 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 381754012168 dimerization interface [polypeptide binding]; other site 381754012169 ligand binding site [chemical binding]; other site 381754012170 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381754012171 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 381754012172 TM-ABC transporter signature motif; other site 381754012173 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 381754012174 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 381754012175 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 381754012176 TM-ABC transporter signature motif; other site 381754012177 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 381754012178 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 381754012179 Walker A/P-loop; other site 381754012180 ATP binding site [chemical binding]; other site 381754012181 Q-loop/lid; other site 381754012182 ABC transporter signature motif; other site 381754012183 Walker B; other site 381754012184 D-loop; other site 381754012185 H-loop/switch region; other site 381754012186 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 381754012187 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 381754012188 Walker A/P-loop; other site 381754012189 ATP binding site [chemical binding]; other site 381754012190 Q-loop/lid; other site 381754012191 ABC transporter signature motif; other site 381754012192 Walker B; other site 381754012193 D-loop; other site 381754012194 H-loop/switch region; other site 381754012195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 381754012196 TPR motif; other site 381754012197 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 381754012198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 381754012199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754012200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754012201 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754012202 putative effector binding pocket; other site 381754012203 dimerization interface [polypeptide binding]; other site 381754012204 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 381754012205 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 381754012206 putative NAD(P) binding site [chemical binding]; other site 381754012207 homodimer interface [polypeptide binding]; other site 381754012208 Uncharacterized conserved protein [Function unknown]; Region: COG3189 381754012209 Predicted membrane protein [Function unknown]; Region: COG3650 381754012210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 381754012211 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 381754012212 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 381754012213 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754012214 catalytic residue [active] 381754012215 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 381754012216 EamA-like transporter family; Region: EamA; pfam00892 381754012217 EamA-like transporter family; Region: EamA; pfam00892 381754012218 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 381754012219 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 381754012220 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 381754012221 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 381754012222 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 381754012223 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 381754012224 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 381754012225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 381754012226 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 381754012227 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 381754012228 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 381754012229 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 381754012230 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 381754012231 fructuronate transporter; Provisional; Region: PRK10034; cl15264 381754012232 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 381754012233 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 381754012234 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 381754012235 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 381754012236 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 381754012237 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 381754012238 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754012239 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754012240 ligand binding site [chemical binding]; other site 381754012241 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 381754012242 Beta-lactamase; Region: Beta-lactamase; pfam00144 381754012243 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 381754012244 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 381754012245 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 381754012246 Predicted integral membrane protein [Function unknown]; Region: COG5615 381754012247 Predicted membrane protein [Function unknown]; Region: COG3776 381754012248 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754012249 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754012250 ligand binding site [chemical binding]; other site 381754012251 hypothetical protein; Provisional; Region: PRK04233 381754012252 SEC-C motif; Region: SEC-C; pfam02810 381754012253 Predicted membrane protein [Function unknown]; Region: COG2860 381754012254 UPF0126 domain; Region: UPF0126; pfam03458 381754012255 UPF0126 domain; Region: UPF0126; pfam03458 381754012256 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 381754012257 Water Stress and Hypersensitive response; Region: WHy; smart00769 381754012258 SEC-C motif; Region: SEC-C; pfam02810 381754012259 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 381754012260 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 381754012261 C-terminal domain interface [polypeptide binding]; other site 381754012262 GSH binding site (G-site) [chemical binding]; other site 381754012263 dimer interface [polypeptide binding]; other site 381754012264 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 381754012265 N-terminal domain interface [polypeptide binding]; other site 381754012266 putative dimer interface [polypeptide binding]; other site 381754012267 active site 381754012268 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 381754012269 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 381754012270 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 381754012271 active site 381754012272 Predicted ATPase [General function prediction only]; Region: COG3911 381754012273 AAA domain; Region: AAA_28; pfam13521 381754012274 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 381754012275 RmuC family; Region: RmuC; pfam02646 381754012276 RES domain; Region: RES; smart00953 381754012277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754012278 salt bridge; other site 381754012279 non-specific DNA binding site [nucleotide binding]; other site 381754012280 sequence-specific DNA binding site [nucleotide binding]; other site 381754012281 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 381754012282 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754012283 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754012284 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 381754012285 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 381754012286 tetrameric interface [polypeptide binding]; other site 381754012287 NAD binding site [chemical binding]; other site 381754012288 catalytic residues [active] 381754012289 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 381754012290 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 381754012291 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 381754012292 FMN binding site [chemical binding]; other site 381754012293 substrate binding site [chemical binding]; other site 381754012294 putative catalytic residue [active] 381754012295 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 381754012296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754012297 NAD(P) binding site [chemical binding]; other site 381754012298 active site 381754012299 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 381754012300 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754012301 active site 381754012302 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 381754012303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754012304 substrate binding site [chemical binding]; other site 381754012305 oxyanion hole (OAH) forming residues; other site 381754012306 trimer interface [polypeptide binding]; other site 381754012307 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 381754012308 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 381754012309 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754012310 active site 381754012311 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754012312 CoenzymeA binding site [chemical binding]; other site 381754012313 subunit interaction site [polypeptide binding]; other site 381754012314 PHB binding site; other site 381754012315 benzoate transport; Region: 2A0115; TIGR00895 381754012316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754012317 putative substrate translocation pore; other site 381754012318 enoyl-CoA hydratase; Region: PLN02864 381754012319 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 381754012320 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 381754012321 dimer interaction site [polypeptide binding]; other site 381754012322 substrate-binding tunnel; other site 381754012323 active site 381754012324 catalytic site [active] 381754012325 substrate binding site [chemical binding]; other site 381754012326 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 381754012327 CoA binding domain; Region: CoA_binding_2; pfam13380 381754012328 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 381754012329 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 381754012330 thiolase; Provisional; Region: PRK06158 381754012331 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 381754012332 active site 381754012333 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 381754012334 DUF35 OB-fold domain; Region: DUF35; pfam01796 381754012335 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 381754012336 Transcriptional regulator [Transcription]; Region: IclR; COG1414 381754012337 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 381754012338 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 381754012339 Walker A/P-loop; other site 381754012340 ATP binding site [chemical binding]; other site 381754012341 Q-loop/lid; other site 381754012342 ABC transporter signature motif; other site 381754012343 Walker B; other site 381754012344 D-loop; other site 381754012345 H-loop/switch region; other site 381754012346 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381754012347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754012348 dimer interface [polypeptide binding]; other site 381754012349 conserved gate region; other site 381754012350 putative PBP binding loops; other site 381754012351 ABC-ATPase subunit interface; other site 381754012352 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 381754012353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754012354 ABC-ATPase subunit interface; other site 381754012355 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 381754012356 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754012357 substrate binding pocket [chemical binding]; other site 381754012358 membrane-bound complex binding site; other site 381754012359 hinge residues; other site 381754012360 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754012361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754012362 DNA-binding site [nucleotide binding]; DNA binding site 381754012363 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754012364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754012365 homodimer interface [polypeptide binding]; other site 381754012366 catalytic residue [active] 381754012367 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 381754012368 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 381754012369 tetramer interface [polypeptide binding]; other site 381754012370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754012371 catalytic residue [active] 381754012372 ectoine utilization protein EutC; Validated; Region: PRK08291 381754012373 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 381754012374 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 381754012375 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 381754012376 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 381754012377 active site 381754012378 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 381754012379 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 381754012380 putative active site [active] 381754012381 Zn binding site [ion binding]; other site 381754012382 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754012383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754012384 putative DNA binding site [nucleotide binding]; other site 381754012385 putative Zn2+ binding site [ion binding]; other site 381754012386 AsnC family; Region: AsnC_trans_reg; pfam01037 381754012387 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 381754012388 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 381754012389 tetramerization interface [polypeptide binding]; other site 381754012390 NAD(P) binding site [chemical binding]; other site 381754012391 catalytic residues [active] 381754012392 hypothetical protein; Provisional; Region: PRK07482 381754012393 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754012394 inhibitor-cofactor binding pocket; inhibition site 381754012395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754012396 catalytic residue [active] 381754012397 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 381754012398 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 381754012399 ATP binding site [chemical binding]; other site 381754012400 active site 381754012401 substrate binding site [chemical binding]; other site 381754012402 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 381754012403 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 381754012404 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 381754012405 dihydrodipicolinate synthase; Region: dapA; TIGR00674 381754012406 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 381754012407 dimer interface [polypeptide binding]; other site 381754012408 active site 381754012409 catalytic residue [active] 381754012410 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 381754012411 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 381754012412 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 381754012413 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 381754012414 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 381754012415 catalytic triad [active] 381754012416 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 381754012417 Domain of unknown function DUF20; Region: UPF0118; pfam01594 381754012418 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 381754012419 CPxP motif; other site 381754012420 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 381754012421 Peptidase family M48; Region: Peptidase_M48; cl12018 381754012422 quinolinate synthetase; Provisional; Region: PRK09375 381754012423 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 381754012424 Glutamine amidotransferase class-I; Region: GATase; pfam00117 381754012425 glutamine binding [chemical binding]; other site 381754012426 catalytic triad [active] 381754012427 anthranilate synthase component I, proteobacterial subset; Region: trpE_proteo; TIGR00565 381754012428 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 381754012429 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 381754012430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381754012431 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 381754012432 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 381754012433 dimer interface [polypeptide binding]; other site 381754012434 active site 381754012435 CoA binding pocket [chemical binding]; other site 381754012436 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 381754012437 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 381754012438 active site 381754012439 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 381754012440 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 381754012441 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 381754012442 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 381754012443 acyl-activating enzyme (AAE) consensus motif; other site 381754012444 AMP binding site [chemical binding]; other site 381754012445 active site 381754012446 CoA binding site [chemical binding]; other site 381754012447 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 381754012448 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 381754012449 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 381754012450 DNA binding site [nucleotide binding] 381754012451 active site 381754012452 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 381754012453 PapC N-terminal domain; Region: PapC_N; pfam13954 381754012454 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 381754012455 PapC C-terminal domain; Region: PapC_C; pfam13953 381754012456 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 381754012457 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 381754012458 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 381754012459 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381754012460 putative binding surface; other site 381754012461 active site 381754012462 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754012463 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754012464 substrate binding pocket [chemical binding]; other site 381754012465 membrane-bound complex binding site; other site 381754012466 hinge residues; other site 381754012467 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754012468 substrate binding pocket [chemical binding]; other site 381754012469 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754012470 membrane-bound complex binding site; other site 381754012471 hinge residues; other site 381754012472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754012473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754012474 dimer interface [polypeptide binding]; other site 381754012475 phosphorylation site [posttranslational modification] 381754012476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754012477 ATP binding site [chemical binding]; other site 381754012478 Mg2+ binding site [ion binding]; other site 381754012479 G-X-G motif; other site 381754012480 Response regulator receiver domain; Region: Response_reg; pfam00072 381754012481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754012482 active site 381754012483 phosphorylation site [posttranslational modification] 381754012484 intermolecular recognition site; other site 381754012485 dimerization interface [polypeptide binding]; other site 381754012486 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 381754012487 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 381754012488 SnoaL-like domain; Region: SnoaL_2; pfam12680 381754012489 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 381754012490 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 381754012491 catalytic Zn binding site [ion binding]; other site 381754012492 NAD binding site [chemical binding]; other site 381754012493 structural Zn binding site [ion binding]; other site 381754012494 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 381754012495 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 381754012496 putative NAD(P) binding site [chemical binding]; other site 381754012497 LysR family transcriptional regulator; Provisional; Region: PRK14997 381754012498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754012499 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 381754012500 putative effector binding pocket; other site 381754012501 putative dimerization interface [polypeptide binding]; other site 381754012502 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 381754012503 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 381754012504 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754012505 N-terminal plug; other site 381754012506 ligand-binding site [chemical binding]; other site 381754012507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754012508 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 381754012509 Walker A/P-loop; other site 381754012510 ATP binding site [chemical binding]; other site 381754012511 Q-loop/lid; other site 381754012512 ABC transporter signature motif; other site 381754012513 Walker B; other site 381754012514 D-loop; other site 381754012515 H-loop/switch region; other site 381754012516 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754012517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754012518 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 381754012519 Walker A/P-loop; other site 381754012520 ATP binding site [chemical binding]; other site 381754012521 Q-loop/lid; other site 381754012522 ABC transporter signature motif; other site 381754012523 Walker B; other site 381754012524 D-loop; other site 381754012525 H-loop/switch region; other site 381754012526 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754012527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754012528 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754012529 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 381754012530 nucleophilic elbow; other site 381754012531 catalytic triad; other site 381754012532 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 381754012533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754012534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754012535 dimerization interface [polypeptide binding]; other site 381754012536 HTH-like domain; Region: HTH_21; pfam13276 381754012537 Integrase core domain; Region: rve; pfam00665 381754012538 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381754012539 Integrase core domain; Region: rve_3; pfam13683 381754012540 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 381754012541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754012542 ATP binding site [chemical binding]; other site 381754012543 putative Mg++ binding site [ion binding]; other site 381754012544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754012545 nucleotide binding region [chemical binding]; other site 381754012546 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 381754012547 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 381754012548 tellurite resistance protein terB; Region: terB; cd07176 381754012549 putative metal binding site [ion binding]; other site 381754012550 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 381754012551 Putative helicase; Region: TraI_2; pfam07514 381754012552 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 381754012553 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 381754012554 active site 381754012555 catalytic residues [active] 381754012556 DNA binding site [nucleotide binding] 381754012557 Int/Topo IB signature motif; other site 381754012558 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 381754012559 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381754012560 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754012561 Magnesium ion binding site [ion binding]; other site 381754012562 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 381754012563 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 381754012564 HNH endonuclease; Region: HNH_3; pfam13392 381754012565 replicative DNA helicase; Region: DnaB; TIGR00665 381754012566 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 381754012567 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 381754012568 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 381754012569 Walker A motif; other site 381754012570 ATP binding site [chemical binding]; other site 381754012571 Walker B motif; other site 381754012572 DNA binding loops [nucleotide binding] 381754012573 Nucleoid-associated protein [General function prediction only]; Region: COG3081 381754012574 nucleoid-associated protein NdpA; Validated; Region: PRK00378 381754012575 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 381754012576 Arc-like DNA binding domain; Region: Arc; pfam03869 381754012577 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 381754012578 ParB-like nuclease domain; Region: ParB; smart00470 381754012579 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 381754012580 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 381754012581 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 381754012582 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 381754012583 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 381754012584 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 381754012585 dimer interface [polypeptide binding]; other site 381754012586 ssDNA binding site [nucleotide binding]; other site 381754012587 tetramer (dimer of dimers) interface [polypeptide binding]; other site 381754012588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 381754012589 Helix-turn-helix domain; Region: HTH_19; pfam12844 381754012590 sequence-specific DNA binding site [nucleotide binding]; other site 381754012591 salt bridge; other site 381754012592 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 381754012593 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 381754012594 active site 381754012595 interdomain interaction site; other site 381754012596 putative metal-binding site [ion binding]; other site 381754012597 nucleotide binding site [chemical binding]; other site 381754012598 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 381754012599 domain I; other site 381754012600 DNA binding groove [nucleotide binding] 381754012601 phosphate binding site [ion binding]; other site 381754012602 domain II; other site 381754012603 domain III; other site 381754012604 nucleotide binding site [chemical binding]; other site 381754012605 catalytic site [active] 381754012606 domain IV; other site 381754012607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754012608 ATP binding site [chemical binding]; other site 381754012609 putative Mg++ binding site [ion binding]; other site 381754012610 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 381754012611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754012612 nucleotide binding region [chemical binding]; other site 381754012613 ATP-binding site [chemical binding]; other site 381754012614 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 381754012615 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 381754012616 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 381754012617 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 381754012618 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 381754012619 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381754012620 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 381754012621 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 381754012622 Type II/IV secretion system protein; Region: T2SE; pfam00437 381754012623 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 381754012624 Walker A motif; other site 381754012625 ATP binding site [chemical binding]; other site 381754012626 Walker B motif; other site 381754012627 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754012628 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754012629 PilS N terminal; Region: PilS; pfam08805 381754012630 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 381754012631 Walker A motif; other site 381754012632 ATP binding site [chemical binding]; other site 381754012633 Walker B motif; other site 381754012634 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 381754012635 PilM; Region: PilM; pfam07419 381754012636 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 381754012637 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 381754012638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754012639 S-adenosylmethionine binding site [chemical binding]; other site 381754012640 DEAD-like helicases superfamily; Region: DEXDc; smart00487 381754012641 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 381754012642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 381754012643 putative Mg++ binding site [ion binding]; other site 381754012644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754012645 nucleotide binding region [chemical binding]; other site 381754012646 ATP-binding site [chemical binding]; other site 381754012647 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 381754012648 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 381754012649 internal virion protein C; Region: PHA00431 381754012650 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 381754012651 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 381754012652 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 381754012653 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 381754012654 Family description; Region: UvrD_C_2; pfam13538 381754012655 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 381754012656 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 381754012657 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 381754012658 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 381754012659 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 381754012660 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 381754012661 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 381754012662 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 381754012663 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 381754012664 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 381754012665 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 381754012666 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 381754012667 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 381754012668 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 381754012669 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381754012670 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 381754012671 Thioredoxin; Region: Thioredoxin_4; cl17273 381754012672 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 381754012673 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 381754012674 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 381754012675 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 381754012676 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 381754012677 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 381754012678 Transposase, Mutator family; Region: Transposase_mut; pfam00872 381754012679 MULE transposase domain; Region: MULE; pfam10551 381754012680 Putative helicase; Region: TraI_2; pfam07514 381754012681 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 381754012682 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 381754012683 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 381754012684 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 381754012685 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 381754012686 active site 381754012687 catalytic residues [active] 381754012688 DNA binding site [nucleotide binding] 381754012689 Int/Topo IB signature motif; other site 381754012690 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 381754012691 Ligand Binding Site [chemical binding]; other site 381754012692 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 381754012693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754012694 FeS/SAM binding site; other site 381754012695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 381754012696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754012697 binding surface 381754012698 TPR motif; other site 381754012699 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754012700 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754012701 ligand binding site [chemical binding]; other site 381754012702 translocation protein TolB; Provisional; Region: tolB; PRK00178 381754012703 TolB amino-terminal domain; Region: TolB_N; pfam04052 381754012704 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 381754012705 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 381754012706 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 381754012707 TolA protein; Region: tolA_full; TIGR02794 381754012708 TolA protein; Region: tolA_full; TIGR02794 381754012709 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 381754012710 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 381754012711 TolR protein; Region: tolR; TIGR02801 381754012712 TolQ protein; Region: tolQ; TIGR02796 381754012713 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 381754012714 active site 381754012715 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 381754012716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754012717 Walker A motif; other site 381754012718 ATP binding site [chemical binding]; other site 381754012719 Walker B motif; other site 381754012720 arginine finger; other site 381754012721 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 381754012722 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 381754012723 RuvA N terminal domain; Region: RuvA_N; pfam01330 381754012724 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 381754012725 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 381754012726 active site 381754012727 putative DNA-binding cleft [nucleotide binding]; other site 381754012728 dimer interface [polypeptide binding]; other site 381754012729 hypothetical protein; Validated; Region: PRK00110 381754012730 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 381754012731 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 381754012732 dimer interface [polypeptide binding]; other site 381754012733 anticodon binding site; other site 381754012734 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 381754012735 homodimer interface [polypeptide binding]; other site 381754012736 motif 1; other site 381754012737 active site 381754012738 motif 2; other site 381754012739 GAD domain; Region: GAD; pfam02938 381754012740 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 381754012741 active site 381754012742 motif 3; other site 381754012743 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 381754012744 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 381754012745 dimerization interface [polypeptide binding]; other site 381754012746 DPS ferroxidase diiron center [ion binding]; other site 381754012747 ion pore; other site 381754012748 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 381754012749 DNA-binding site [nucleotide binding]; DNA binding site 381754012750 RNA-binding motif; other site 381754012751 hypothetical protein; Provisional; Region: PRK00295 381754012752 HIT domain; Region: HIT; pfam01230 381754012753 nucleotide binding site/active site [active] 381754012754 HIT family signature motif; other site 381754012755 catalytic residue [active] 381754012756 outer membrane porin, OprD family; Region: OprD; pfam03573 381754012757 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754012758 CoenzymeA binding site [chemical binding]; other site 381754012759 subunit interaction site [polypeptide binding]; other site 381754012760 PHB binding site; other site 381754012761 prolyl-tRNA synthetase; Provisional; Region: PRK09194 381754012762 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 381754012763 dimer interface [polypeptide binding]; other site 381754012764 motif 1; other site 381754012765 active site 381754012766 motif 2; other site 381754012767 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 381754012768 putative deacylase active site [active] 381754012769 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 381754012770 active site 381754012771 motif 3; other site 381754012772 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 381754012773 anticodon binding site; other site 381754012774 acylphosphatase; Provisional; Region: PRK14442 381754012775 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 381754012776 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 381754012777 catalytic residues [active] 381754012778 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 381754012779 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 381754012780 ArsC family; Region: ArsC; pfam03960 381754012781 catalytic residues [active] 381754012782 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 381754012783 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754012784 Predicted membrane protein [Function unknown]; Region: COG3308 381754012785 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 381754012786 DNA replication initiation factor; Validated; Region: PRK05642 381754012787 Walker A motif; other site 381754012788 ATP binding site [chemical binding]; other site 381754012789 Walker B motif; other site 381754012790 arginine finger; other site 381754012791 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 381754012792 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 381754012793 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 381754012794 dimerization interface [polypeptide binding]; other site 381754012795 putative ATP binding site [chemical binding]; other site 381754012796 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 381754012797 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 381754012798 active site 381754012799 substrate binding site [chemical binding]; other site 381754012800 cosubstrate binding site; other site 381754012801 catalytic site [active] 381754012802 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 381754012803 Transcriptional regulators [Transcription]; Region: MarR; COG1846 381754012804 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 381754012805 MarR family; Region: MarR_2; cl17246 381754012806 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 381754012807 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 381754012808 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 381754012809 Chain length determinant protein; Region: Wzz; cl15801 381754012810 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 381754012811 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 381754012812 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 381754012813 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 381754012814 homodimer interface [polypeptide binding]; other site 381754012815 metal binding site [ion binding]; metal-binding site 381754012816 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 381754012817 homodimer interface [polypeptide binding]; other site 381754012818 active site 381754012819 putative chemical substrate binding site [chemical binding]; other site 381754012820 metal binding site [ion binding]; metal-binding site 381754012821 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 381754012822 HD domain; Region: HD_4; pfam13328 381754012823 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 381754012824 synthetase active site [active] 381754012825 NTP binding site [chemical binding]; other site 381754012826 metal binding site [ion binding]; metal-binding site 381754012827 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 381754012828 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 381754012829 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 381754012830 TRAM domain; Region: TRAM; pfam01938 381754012831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754012832 S-adenosylmethionine binding site [chemical binding]; other site 381754012833 cysteine synthase B; Region: cysM; TIGR01138 381754012834 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 381754012835 dimer interface [polypeptide binding]; other site 381754012836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754012837 catalytic residue [active] 381754012838 outer membrane receptor FepA; Provisional; Region: PRK13528 381754012839 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754012840 N-terminal plug; other site 381754012841 ligand-binding site [chemical binding]; other site 381754012842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754012843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754012844 dimerization interface [polypeptide binding]; other site 381754012845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754012846 dimer interface [polypeptide binding]; other site 381754012847 phosphorylation site [posttranslational modification] 381754012848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754012849 ATP binding site [chemical binding]; other site 381754012850 Mg2+ binding site [ion binding]; other site 381754012851 G-X-G motif; other site 381754012852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754012853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754012854 active site 381754012855 phosphorylation site [posttranslational modification] 381754012856 intermolecular recognition site; other site 381754012857 dimerization interface [polypeptide binding]; other site 381754012858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754012859 DNA binding site [nucleotide binding] 381754012860 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 381754012861 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754012862 dimerization interface [polypeptide binding]; other site 381754012863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754012864 dimer interface [polypeptide binding]; other site 381754012865 phosphorylation site [posttranslational modification] 381754012866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754012867 ATP binding site [chemical binding]; other site 381754012868 Mg2+ binding site [ion binding]; other site 381754012869 G-X-G motif; other site 381754012870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754012871 active site 381754012872 phosphorylation site [posttranslational modification] 381754012873 intermolecular recognition site; other site 381754012874 dimerization interface [polypeptide binding]; other site 381754012875 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 381754012876 putative binding surface; other site 381754012877 active site 381754012878 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 381754012879 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 381754012880 putative ligand binding site [chemical binding]; other site 381754012881 putative NAD binding site [chemical binding]; other site 381754012882 catalytic site [active] 381754012883 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 381754012884 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 381754012885 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 381754012886 Sulfatase; Region: Sulfatase; pfam00884 381754012887 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 381754012888 active site 381754012889 DNA polymerase IV; Validated; Region: PRK02406 381754012890 DNA binding site [nucleotide binding] 381754012891 Replication protein A C terminal; Region: RPA_C; pfam08784 381754012892 Predicted integral membrane protein [Function unknown]; Region: COG0392 381754012893 Uncharacterized conserved protein [Function unknown]; Region: COG2898 381754012894 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 381754012895 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 381754012896 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 381754012897 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 381754012898 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 381754012899 potassium uptake protein; Region: kup; TIGR00794 381754012900 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 381754012901 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 381754012902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381754012903 FeS/SAM binding site; other site 381754012904 TRAM domain; Region: TRAM; cl01282 381754012905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 381754012906 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 381754012907 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 381754012908 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 381754012909 MgtE intracellular N domain; Region: MgtE_N; smart00924 381754012910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 381754012911 Divalent cation transporter; Region: MgtE; pfam01769 381754012912 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 381754012913 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 381754012914 Protein of unknown function (DUF754); Region: DUF754; pfam05449 381754012915 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 381754012916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754012917 non-specific DNA binding site [nucleotide binding]; other site 381754012918 Predicted transcriptional regulator [Transcription]; Region: COG2932 381754012919 salt bridge; other site 381754012920 sequence-specific DNA binding site [nucleotide binding]; other site 381754012921 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 381754012922 Catalytic site [active] 381754012923 carbon storage regulator; Provisional; Region: PRK01712 381754012924 aspartate kinase; Reviewed; Region: PRK06635 381754012925 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 381754012926 putative nucleotide binding site [chemical binding]; other site 381754012927 putative catalytic residues [active] 381754012928 putative Mg ion binding site [ion binding]; other site 381754012929 putative aspartate binding site [chemical binding]; other site 381754012930 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 381754012931 putative allosteric regulatory site; other site 381754012932 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 381754012933 putative allosteric regulatory residue; other site 381754012934 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 381754012935 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 381754012936 motif 1; other site 381754012937 active site 381754012938 motif 2; other site 381754012939 motif 3; other site 381754012940 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 381754012941 DHHA1 domain; Region: DHHA1; pfam02272 381754012942 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 381754012943 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 381754012944 tetramer interface [polypeptide binding]; other site 381754012945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754012946 catalytic residue [active] 381754012947 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 381754012948 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 381754012949 putative active site [active] 381754012950 Zn binding site [ion binding]; other site 381754012951 succinylarginine dihydrolase; Provisional; Region: PRK13281 381754012952 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 381754012953 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 381754012954 NAD(P) binding site [chemical binding]; other site 381754012955 catalytic residues [active] 381754012956 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 381754012957 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 381754012958 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 381754012959 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 381754012960 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 381754012961 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754012962 inhibitor-cofactor binding pocket; inhibition site 381754012963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754012964 catalytic residue [active] 381754012965 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 381754012966 conserved cys residue [active] 381754012967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754012968 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754012969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754012970 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 381754012971 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 381754012972 Walker A/P-loop; other site 381754012973 ATP binding site [chemical binding]; other site 381754012974 Q-loop/lid; other site 381754012975 ABC transporter signature motif; other site 381754012976 Walker B; other site 381754012977 D-loop; other site 381754012978 H-loop/switch region; other site 381754012979 Predicted deacylase [General function prediction only]; Region: COG3608 381754012980 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 381754012981 active site 381754012982 Zn binding site [ion binding]; other site 381754012983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754012984 dimer interface [polypeptide binding]; other site 381754012985 conserved gate region; other site 381754012986 putative PBP binding loops; other site 381754012987 ABC-ATPase subunit interface; other site 381754012988 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381754012989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754012990 dimer interface [polypeptide binding]; other site 381754012991 conserved gate region; other site 381754012992 putative PBP binding loops; other site 381754012993 ABC-ATPase subunit interface; other site 381754012994 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 381754012995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754012996 substrate binding pocket [chemical binding]; other site 381754012997 membrane-bound complex binding site; other site 381754012998 hinge residues; other site 381754012999 acetyl-CoA synthetase; Provisional; Region: PRK00174 381754013000 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 381754013001 active site 381754013002 CoA binding site [chemical binding]; other site 381754013003 acyl-activating enzyme (AAE) consensus motif; other site 381754013004 AMP binding site [chemical binding]; other site 381754013005 acetate binding site [chemical binding]; other site 381754013006 DctM-like transporters; Region: DctM; pfam06808 381754013007 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 381754013008 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 381754013009 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 381754013010 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 381754013011 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 381754013012 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 381754013013 CoA-transferase family III; Region: CoA_transf_3; pfam02515 381754013014 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 381754013015 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 381754013016 dimer interface [polypeptide binding]; other site 381754013017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754013018 metal binding site [ion binding]; metal-binding site 381754013019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754013020 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754013021 active site 381754013022 Uncharacterized conserved protein [Function unknown]; Region: COG3777 381754013023 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 381754013024 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 381754013025 active site 2 [active] 381754013026 active site 1 [active] 381754013027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754013028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754013029 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 381754013030 putative dimerization interface [polypeptide binding]; other site 381754013031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754013032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754013033 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 381754013034 putative effector binding pocket; other site 381754013035 dimerization interface [polypeptide binding]; other site 381754013036 Fusaric acid resistance protein family; Region: FUSC; pfam04632 381754013037 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 381754013038 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 381754013039 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 381754013040 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 381754013041 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 381754013042 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 381754013043 haemagglutination activity domain; Region: Haemagg_act; pfam05860 381754013044 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 381754013045 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 381754013046 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 381754013047 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 381754013048 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 381754013049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754013050 putative active site [active] 381754013051 heme pocket [chemical binding]; other site 381754013052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754013053 Walker A motif; other site 381754013054 ATP binding site [chemical binding]; other site 381754013055 Walker B motif; other site 381754013056 arginine finger; other site 381754013057 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 381754013058 cofactor binding site; other site 381754013059 metal binding site [ion binding]; metal-binding site 381754013060 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 381754013061 aromatic arch; other site 381754013062 DCoH dimer interaction site [polypeptide binding]; other site 381754013063 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 381754013064 DCoH tetramer interaction site [polypeptide binding]; other site 381754013065 substrate binding site [chemical binding]; other site 381754013066 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 381754013067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754013068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754013069 homodimer interface [polypeptide binding]; other site 381754013070 catalytic residue [active] 381754013071 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 381754013072 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 381754013073 hypothetical protein; Provisional; Region: PRK09256 381754013074 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 381754013075 lysozyme inhibitor; Provisional; Region: PRK13792 381754013076 Predicted periplasmic protein [General function prediction only]; Region: COG3895 381754013077 aromatic amino acid transporter; Provisional; Region: PRK10238 381754013078 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 381754013079 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 381754013080 dimer interface [polypeptide binding]; other site 381754013081 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 381754013082 active site 381754013083 Fe binding site [ion binding]; other site 381754013084 Cupin domain; Region: Cupin_2; cl17218 381754013085 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754013086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754013087 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 381754013088 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 381754013089 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 381754013090 putative NAD(P) binding site [chemical binding]; other site 381754013091 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 381754013092 PAS domain S-box; Region: sensory_box; TIGR00229 381754013093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754013094 putative active site [active] 381754013095 heme pocket [chemical binding]; other site 381754013096 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754013097 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754013098 metal binding site [ion binding]; metal-binding site 381754013099 active site 381754013100 I-site; other site 381754013101 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754013102 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754013103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754013104 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 381754013105 Walker A/P-loop; other site 381754013106 ATP binding site [chemical binding]; other site 381754013107 Q-loop/lid; other site 381754013108 ABC transporter signature motif; other site 381754013109 Walker B; other site 381754013110 D-loop; other site 381754013111 H-loop/switch region; other site 381754013112 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 381754013113 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 381754013114 catalytic residues [active] 381754013115 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 381754013116 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 381754013117 active site residue [active] 381754013118 BolA-like protein; Region: BolA; cl00386 381754013119 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 381754013120 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 381754013121 fumarate hydratase; Provisional; Region: PRK12425 381754013122 Class II fumarases; Region: Fumarase_classII; cd01362 381754013123 active site 381754013124 tetramer interface [polypeptide binding]; other site 381754013125 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 381754013126 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754013127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 381754013128 Chitin binding domain; Region: Chitin_bind_3; pfam03067 381754013129 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 381754013130 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 381754013131 tetramer interface [polypeptide binding]; other site 381754013132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754013133 catalytic residue [active] 381754013134 MAPEG family; Region: MAPEG; pfam01124 381754013135 thioredoxin reductase; Provisional; Region: PRK10262 381754013136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754013137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754013138 peroxidase; Provisional; Region: PRK15000 381754013139 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 381754013140 dimer interface [polypeptide binding]; other site 381754013141 decamer (pentamer of dimers) interface [polypeptide binding]; other site 381754013142 catalytic triad [active] 381754013143 peroxidatic and resolving cysteines [active] 381754013144 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 381754013145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754013146 dimerization interface [polypeptide binding]; other site 381754013147 PAS domain S-box; Region: sensory_box; TIGR00229 381754013148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754013149 putative active site [active] 381754013150 heme pocket [chemical binding]; other site 381754013151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754013152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754013153 metal binding site [ion binding]; metal-binding site 381754013154 active site 381754013155 I-site; other site 381754013156 putative sulfate transport protein CysZ; Validated; Region: PRK04949 381754013157 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 381754013158 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 381754013159 Phosphoesterase family; Region: Phosphoesterase; pfam04185 381754013160 Domain of unknown function (DUF756); Region: DUF756; pfam05506 381754013161 Domain of unknown function (DUF756); Region: DUF756; pfam05506 381754013162 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 381754013163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754013164 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 381754013165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 381754013166 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 381754013167 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 381754013168 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 381754013169 putative active site [active] 381754013170 putative FMN binding site [chemical binding]; other site 381754013171 putative substrate binding site [chemical binding]; other site 381754013172 putative catalytic residue [active] 381754013173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754013174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754013175 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 381754013176 catalytic residues [active] 381754013177 dimer interface [polypeptide binding]; other site 381754013178 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 381754013179 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 381754013180 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 381754013181 propionate/acetate kinase; Provisional; Region: PRK12379 381754013182 phosphate acetyltransferase; Reviewed; Region: PRK05632 381754013183 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381754013184 DRTGG domain; Region: DRTGG; pfam07085 381754013185 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 381754013186 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 381754013187 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 381754013188 putative acyl-acceptor binding pocket; other site 381754013189 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754013190 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754013191 ligand binding site [chemical binding]; other site 381754013192 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 381754013193 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754013194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754013195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754013196 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 381754013197 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 381754013198 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754013199 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 381754013200 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 381754013201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754013202 HTH-like domain; Region: HTH_21; pfam13276 381754013203 Integrase core domain; Region: rve; pfam00665 381754013204 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381754013205 Integrase core domain; Region: rve_3; pfam13683 381754013206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381754013207 Transposase; Region: HTH_Tnp_1; pfam01527 381754013208 TM2 domain; Region: TM2; pfam05154 381754013209 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 381754013210 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754013211 putative metal binding site [ion binding]; other site 381754013212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754013213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754013214 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 381754013215 putative dimerization interface [polypeptide binding]; other site 381754013216 cell density-dependent motility repressor; Provisional; Region: PRK10082 381754013217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754013218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754013219 dimerization interface [polypeptide binding]; other site 381754013220 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 381754013221 homotrimer interaction site [polypeptide binding]; other site 381754013222 putative active site [active] 381754013223 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 381754013224 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 381754013225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754013226 catalytic residue [active] 381754013227 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 381754013228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754013229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754013230 putative substrate translocation pore; other site 381754013231 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 381754013232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754013233 motif II; other site 381754013234 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 381754013235 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 381754013236 putative hydrophobic ligand binding site [chemical binding]; other site 381754013237 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 381754013238 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 381754013239 amidase catalytic site [active] 381754013240 Zn binding residues [ion binding]; other site 381754013241 substrate binding site [chemical binding]; other site 381754013242 Predicted membrane protein [Function unknown]; Region: COG4270 381754013243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 381754013244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 381754013245 active site 381754013246 catalytic tetrad [active] 381754013247 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 381754013248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754013249 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 381754013250 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 381754013251 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 381754013252 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 381754013253 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 381754013254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754013255 ATP binding site [chemical binding]; other site 381754013256 putative Mg++ binding site [ion binding]; other site 381754013257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754013258 nucleotide binding region [chemical binding]; other site 381754013259 ATP-binding site [chemical binding]; other site 381754013260 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754013261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754013262 S-adenosylmethionine binding site [chemical binding]; other site 381754013263 Transcriptional regulators [Transcription]; Region: GntR; COG1802 381754013264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754013265 DNA-binding site [nucleotide binding]; DNA binding site 381754013266 FCD domain; Region: FCD; pfam07729 381754013267 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 381754013268 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 381754013269 tetramer interface [polypeptide binding]; other site 381754013270 active site 381754013271 Mg2+/Mn2+ binding site [ion binding]; other site 381754013272 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 381754013273 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 381754013274 dimer interface [polypeptide binding]; other site 381754013275 active site 381754013276 citrylCoA binding site [chemical binding]; other site 381754013277 oxalacetate/citrate binding site [chemical binding]; other site 381754013278 coenzyme A binding site [chemical binding]; other site 381754013279 catalytic triad [active] 381754013280 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 381754013281 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 381754013282 substrate binding site [chemical binding]; other site 381754013283 ligand binding site [chemical binding]; other site 381754013284 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 381754013285 substrate binding site [chemical binding]; other site 381754013286 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 381754013287 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 381754013288 2-methylcitrate dehydratase; Region: prpD; TIGR02330 381754013289 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754013290 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754013291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754013292 Predicted permeases [General function prediction only]; Region: COG0730 381754013293 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 381754013294 Spore germination protein; Region: Spore_permease; cl17796 381754013295 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 381754013296 Transglycosylase; Region: Transgly; cl17702 381754013297 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 381754013298 Predicted ATPase [General function prediction only]; Region: COG4637 381754013299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754013300 Walker A/P-loop; other site 381754013301 ATP binding site [chemical binding]; other site 381754013302 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 381754013303 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 381754013304 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754013305 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754013306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754013307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754013308 dimerization interface [polypeptide binding]; other site 381754013309 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 381754013310 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 381754013311 Na binding site [ion binding]; other site 381754013312 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 381754013313 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 381754013314 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 381754013315 Glutamate binding site [chemical binding]; other site 381754013316 NAD binding site [chemical binding]; other site 381754013317 catalytic residues [active] 381754013318 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 381754013319 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754013320 N-terminal plug; other site 381754013321 ligand-binding site [chemical binding]; other site 381754013322 Cupin domain; Region: Cupin_2; cl17218 381754013323 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754013324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754013325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754013326 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 381754013327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754013328 Walker A motif; other site 381754013329 ATP binding site [chemical binding]; other site 381754013330 Walker B motif; other site 381754013331 arginine finger; other site 381754013332 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 381754013333 Predicted secreted protein [Function unknown]; Region: COG5513 381754013334 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 381754013335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 381754013336 membrane-bound complex binding site; other site 381754013337 hinge residues; other site 381754013338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754013339 S-adenosylmethionine binding site [chemical binding]; other site 381754013340 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754013341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754013342 S-adenosylmethionine binding site [chemical binding]; other site 381754013343 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 381754013344 active site 381754013345 hydrophilic channel; other site 381754013346 dimerization interface [polypeptide binding]; other site 381754013347 catalytic residues [active] 381754013348 active site lid [active] 381754013349 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 381754013350 Recombination protein O N terminal; Region: RecO_N; pfam11967 381754013351 Recombination protein O C terminal; Region: RecO_C; pfam02565 381754013352 GTPase Era; Reviewed; Region: era; PRK00089 381754013353 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 381754013354 G1 box; other site 381754013355 GTP/Mg2+ binding site [chemical binding]; other site 381754013356 Switch I region; other site 381754013357 G2 box; other site 381754013358 Switch II region; other site 381754013359 G3 box; other site 381754013360 G4 box; other site 381754013361 G5 box; other site 381754013362 KH domain; Region: KH_2; pfam07650 381754013363 ribonuclease III; Reviewed; Region: rnc; PRK00102 381754013364 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 381754013365 dimerization interface [polypeptide binding]; other site 381754013366 active site 381754013367 metal binding site [ion binding]; metal-binding site 381754013368 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 381754013369 dsRNA binding site [nucleotide binding]; other site 381754013370 signal peptidase I; Provisional; Region: PRK10861 381754013371 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 381754013372 Catalytic site [active] 381754013373 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 381754013374 GTP-binding protein LepA; Provisional; Region: PRK05433 381754013375 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 381754013376 G1 box; other site 381754013377 putative GEF interaction site [polypeptide binding]; other site 381754013378 GTP/Mg2+ binding site [chemical binding]; other site 381754013379 Switch I region; other site 381754013380 G2 box; other site 381754013381 G3 box; other site 381754013382 Switch II region; other site 381754013383 G4 box; other site 381754013384 G5 box; other site 381754013385 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 381754013386 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 381754013387 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 381754013388 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 381754013389 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 381754013390 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 381754013391 protein binding site [polypeptide binding]; other site 381754013392 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 381754013393 protein binding site [polypeptide binding]; other site 381754013394 Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086 381754013395 MucB/RseB family; Region: MucB_RseB; pfam03888 381754013396 anti-sigma E factor; Provisional; Region: rseB; PRK09455 381754013397 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 381754013398 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 381754013399 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 381754013400 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 381754013401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754013402 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381754013403 DNA binding residues [nucleotide binding] 381754013404 L-aspartate oxidase; Provisional; Region: PRK09077 381754013405 L-aspartate oxidase; Provisional; Region: PRK06175 381754013406 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 381754013407 Uncharacterized conserved protein [Function unknown]; Region: COG2938 381754013408 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 381754013409 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 381754013410 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 381754013411 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 381754013412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754013413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754013414 dimer interface [polypeptide binding]; other site 381754013415 phosphorylation site [posttranslational modification] 381754013416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754013417 ATP binding site [chemical binding]; other site 381754013418 G-X-G motif; other site 381754013419 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 381754013420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754013421 active site 381754013422 phosphorylation site [posttranslational modification] 381754013423 intermolecular recognition site; other site 381754013424 dimerization interface [polypeptide binding]; other site 381754013425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754013426 DNA binding site [nucleotide binding] 381754013427 outer membrane porin, OprD family; Region: OprD; pfam03573 381754013428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 381754013429 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 381754013430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 381754013431 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 381754013432 Putative ammonia monooxygenase; Region: AmoA; pfam05145 381754013433 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 381754013434 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 381754013435 ligand binding site [chemical binding]; other site 381754013436 active site 381754013437 UGI interface [polypeptide binding]; other site 381754013438 catalytic site [active] 381754013439 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 381754013440 VanW like protein; Region: VanW; pfam04294 381754013441 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754013442 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754013443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754013444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754013445 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 381754013446 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 381754013447 tetrameric interface [polypeptide binding]; other site 381754013448 NAD binding site [chemical binding]; other site 381754013449 catalytic residues [active] 381754013450 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754013451 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 381754013452 substrate binding pocket [chemical binding]; other site 381754013453 FAD binding site [chemical binding]; other site 381754013454 catalytic base [active] 381754013455 enoyl-CoA hydratase; Provisional; Region: PRK09076 381754013456 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754013457 substrate binding site [chemical binding]; other site 381754013458 oxyanion hole (OAH) forming residues; other site 381754013459 trimer interface [polypeptide binding]; other site 381754013460 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 381754013461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754013462 substrate binding site [chemical binding]; other site 381754013463 oxyanion hole (OAH) forming residues; other site 381754013464 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 381754013465 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 381754013466 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 381754013467 Ion channel; Region: Ion_trans_2; pfam07885 381754013468 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 381754013469 NADH(P)-binding; Region: NAD_binding_10; pfam13460 381754013470 NAD binding site [chemical binding]; other site 381754013471 substrate binding site [chemical binding]; other site 381754013472 putative active site [active] 381754013473 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 381754013474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381754013475 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754013476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754013477 LysR substrate binding domain; Region: LysR_substrate; pfam03466 381754013478 dimerization interface [polypeptide binding]; other site 381754013479 Predicted membrane protein [Function unknown]; Region: COG3776 381754013480 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 381754013481 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 381754013482 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381754013483 RNA binding surface [nucleotide binding]; other site 381754013484 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 381754013485 active site 381754013486 uracil binding [chemical binding]; other site 381754013487 hypothetical protein; Provisional; Region: PRK06132 381754013488 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 381754013489 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 381754013490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754013491 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 381754013492 HTH-like domain; Region: HTH_21; pfam13276 381754013493 Integrase core domain; Region: rve; pfam00665 381754013494 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381754013495 Integrase core domain; Region: rve_3; pfam13683 381754013496 hypothetical protein; Provisional; Region: PRK13687 381754013497 putative acetyltransferase; Provisional; Region: PRK03624 381754013498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754013499 Coenzyme A binding pocket [chemical binding]; other site 381754013500 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 381754013501 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 381754013502 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 381754013503 active site 381754013504 trimer interface [polypeptide binding]; other site 381754013505 substrate binding site [chemical binding]; other site 381754013506 CoA binding site [chemical binding]; other site 381754013507 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 381754013508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 381754013509 active site 381754013510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 381754013511 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 381754013512 trimer interface [polypeptide binding]; other site 381754013513 active site 381754013514 substrate binding site [chemical binding]; other site 381754013515 CoA binding site [chemical binding]; other site 381754013516 amidase; Provisional; Region: PRK07042 381754013517 Amidase; Region: Amidase; cl11426 381754013518 citrate-proton symporter; Provisional; Region: PRK15075 381754013519 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 381754013520 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 381754013521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754013522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754013523 LysR substrate binding domain; Region: LysR_substrate; pfam03466 381754013524 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 381754013525 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 381754013526 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 381754013527 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 381754013528 TonB C terminal; Region: TonB_2; pfam13103 381754013529 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 381754013530 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 381754013531 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 381754013532 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 381754013533 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 381754013534 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 381754013535 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 381754013536 Surface antigen; Region: Bac_surface_Ag; pfam01103 381754013537 haemagglutination activity domain; Region: Haemagg_act; pfam05860 381754013538 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 381754013539 PBP superfamily domain; Region: PBP_like_2; cl17296 381754013540 type II secretion system protein F; Region: GspF; TIGR02120 381754013541 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754013542 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754013543 type II secretion system protein E; Region: type_II_gspE; TIGR02533 381754013544 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 381754013545 Walker A motif; other site 381754013546 ATP binding site [chemical binding]; other site 381754013547 Walker B motif; other site 381754013548 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754013549 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754013550 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754013551 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 381754013552 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381754013553 Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149 381754013554 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 381754013555 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 381754013556 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 381754013557 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 381754013558 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 381754013559 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 381754013560 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 381754013561 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 381754013562 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 381754013563 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 381754013564 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754013565 FecR protein; Region: FecR; pfam04773 381754013566 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 381754013567 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 381754013568 DNA binding residues [nucleotide binding] 381754013569 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754013570 Heme oxygenase [Inorganic ion transport and metabolism]; Region: HemO; COG3230 381754013571 heme binding pocket [chemical binding]; other site 381754013572 heme ligand [chemical binding]; other site 381754013573 Cell division inhibitor SulA; Region: SulA; cl01880 381754013574 DNA Polymerase Y-family; Region: PolY_like; cd03468 381754013575 active site 381754013576 DNA binding site [nucleotide binding] 381754013577 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 381754013578 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 381754013579 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 381754013580 putative active site [active] 381754013581 putative PHP Thumb interface [polypeptide binding]; other site 381754013582 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 381754013583 generic binding surface II; other site 381754013584 generic binding surface I; other site 381754013585 exonuclease subunit SbcD; Provisional; Region: PRK10966 381754013586 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 381754013587 active site 381754013588 metal binding site [ion binding]; metal-binding site 381754013589 DNA binding site [nucleotide binding] 381754013590 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 381754013591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754013592 AAA domain; Region: AAA_23; pfam13476 381754013593 Walker A/P-loop; other site 381754013594 ATP binding site [chemical binding]; other site 381754013595 Q-loop/lid; other site 381754013596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754013597 ABC transporter signature motif; other site 381754013598 Walker B; other site 381754013599 D-loop; other site 381754013600 H-loop/switch region; other site 381754013601 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 381754013602 AAA domain; Region: AAA_30; pfam13604 381754013603 Family description; Region: UvrD_C_2; pfam13538 381754013604 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 381754013605 Family description; Region: UvrD_C_2; pfam13538 381754013606 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 381754013607 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 381754013608 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 381754013609 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754013610 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754013611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754013612 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 381754013613 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 381754013614 Chromate transporter; Region: Chromate_transp; pfam02417 381754013615 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754013616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754013617 dimer interface [polypeptide binding]; other site 381754013618 putative CheW interface [polypeptide binding]; other site 381754013619 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381754013620 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381754013621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754013622 PAS fold; Region: PAS_3; pfam08447 381754013623 putative active site [active] 381754013624 heme pocket [chemical binding]; other site 381754013625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754013626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754013627 putative active site [active] 381754013628 heme pocket [chemical binding]; other site 381754013629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754013630 dimer interface [polypeptide binding]; other site 381754013631 phosphorylation site [posttranslational modification] 381754013632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754013633 ATP binding site [chemical binding]; other site 381754013634 Mg2+ binding site [ion binding]; other site 381754013635 G-X-G motif; other site 381754013636 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 381754013637 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 381754013638 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 381754013639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754013640 active site 381754013641 phosphorylation site [posttranslational modification] 381754013642 intermolecular recognition site; other site 381754013643 dimerization interface [polypeptide binding]; other site 381754013644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 381754013645 DNA binding residues [nucleotide binding] 381754013646 dimerization interface [polypeptide binding]; other site 381754013647 Predicted membrane protein [Function unknown]; Region: COG4655 381754013648 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 381754013649 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 381754013650 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 381754013651 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754013652 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 381754013653 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754013654 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 381754013655 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 381754013656 ATP binding site [chemical binding]; other site 381754013657 Walker A motif; other site 381754013658 hexamer interface [polypeptide binding]; other site 381754013659 Walker B motif; other site 381754013660 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 381754013661 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381754013662 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 381754013663 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 381754013664 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381754013665 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 381754013666 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 381754013667 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 381754013668 Cache domain; Region: Cache_1; pfam02743 381754013669 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754013670 dimerization interface [polypeptide binding]; other site 381754013671 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754013672 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754013673 dimer interface [polypeptide binding]; other site 381754013674 putative CheW interface [polypeptide binding]; other site 381754013675 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 381754013676 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 381754013677 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 381754013678 Cache domain; Region: Cache_1; pfam02743 381754013679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754013680 dimerization interface [polypeptide binding]; other site 381754013681 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754013682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754013683 dimer interface [polypeptide binding]; other site 381754013684 putative CheW interface [polypeptide binding]; other site 381754013685 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 381754013686 Cache domain; Region: Cache_1; pfam02743 381754013687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754013688 dimerization interface [polypeptide binding]; other site 381754013689 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754013690 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754013691 dimer interface [polypeptide binding]; other site 381754013692 putative CheW interface [polypeptide binding]; other site 381754013693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754013694 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 381754013695 Predicted deacetylase [General function prediction only]; Region: COG3233 381754013696 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 381754013697 putative active site [active] 381754013698 putative Zn binding site [ion binding]; other site 381754013699 Predicted integral membrane protein [Function unknown]; Region: COG0392 381754013700 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 381754013701 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 381754013702 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 381754013703 putative active site [active] 381754013704 putative substrate binding site [chemical binding]; other site 381754013705 putative cosubstrate binding site; other site 381754013706 catalytic site [active] 381754013707 exonuclease I; Provisional; Region: sbcB; PRK11779 381754013708 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 381754013709 active site 381754013710 catalytic site [active] 381754013711 substrate binding site [chemical binding]; other site 381754013712 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 381754013713 Protein of unknown function (DUF975); Region: DUF975; cl10504 381754013714 Predicted membrane protein/domain [Function unknown]; Region: COG1714 381754013715 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 381754013716 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 381754013717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754013718 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 381754013719 Walker A motif; other site 381754013720 ATP binding site [chemical binding]; other site 381754013721 Walker B motif; other site 381754013722 arginine finger; other site 381754013723 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 381754013724 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 381754013725 metal ion-dependent adhesion site (MIDAS); other site 381754013726 PilZ domain; Region: PilZ; pfam07238 381754013727 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 381754013728 tol-pal system protein YbgF; Provisional; Region: PRK10803 381754013729 universal stress protein UspE; Provisional; Region: PRK11175 381754013730 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754013731 Ligand Binding Site [chemical binding]; other site 381754013732 Universal stress protein family; Region: Usp; pfam00582 381754013733 pyruvate kinase; Provisional; Region: PRK05826 381754013734 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 381754013735 domain interfaces; other site 381754013736 active site 381754013737 enoyl-CoA hydratase; Provisional; Region: PRK06688 381754013738 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754013739 substrate binding site [chemical binding]; other site 381754013740 oxyanion hole (OAH) forming residues; other site 381754013741 trimer interface [polypeptide binding]; other site 381754013742 hypothetical protein; Provisional; Region: PRK05713 381754013743 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754013744 catalytic loop [active] 381754013745 iron binding site [ion binding]; other site 381754013746 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 381754013747 FAD binding pocket [chemical binding]; other site 381754013748 conserved FAD binding motif [chemical binding]; other site 381754013749 phosphate binding motif [ion binding]; other site 381754013750 beta-alpha-beta structure motif; other site 381754013751 NAD binding pocket [chemical binding]; other site 381754013752 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754013753 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754013754 metal binding site [ion binding]; metal-binding site 381754013755 active site 381754013756 I-site; other site 381754013757 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 381754013758 Fumarase C-terminus; Region: Fumerase_C; pfam05683 381754013759 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381754013760 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 381754013761 manganese transport protein MntH; Reviewed; Region: PRK00701 381754013762 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 381754013763 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 381754013764 intracellular protease, PfpI family; Region: PfpI; TIGR01382 381754013765 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 381754013766 conserved cys residue [active] 381754013767 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 381754013768 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 381754013769 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 381754013770 putative active site [active] 381754013771 catalytic site [active] 381754013772 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 381754013773 PLD-like domain; Region: PLDc_2; pfam13091 381754013774 putative active site [active] 381754013775 catalytic site [active] 381754013776 YceI-like domain; Region: YceI; pfam04264 381754013777 Transcriptional regulator [Transcription]; Region: IclR; COG1414 381754013778 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 381754013779 amidase; Provisional; Region: PRK07486 381754013780 Amidase; Region: Amidase; pfam01425 381754013781 citrate-proton symporter; Provisional; Region: PRK15075 381754013782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754013783 putative substrate translocation pore; other site 381754013784 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 381754013785 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 381754013786 metal binding site [ion binding]; metal-binding site 381754013787 putative dimer interface [polypeptide binding]; other site 381754013788 YceI-like domain; Region: YceI; pfam04264 381754013789 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 381754013790 Beta-lactamase; Region: Beta-lactamase; pfam00144 381754013791 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 381754013792 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381754013793 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754013794 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754013795 Putative hemolysin [General function prediction only]; Region: COG3176 381754013796 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 381754013797 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 381754013798 putative acyl-acceptor binding pocket; other site 381754013799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754013800 Ligand Binding Site [chemical binding]; other site 381754013801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754013802 Ligand Binding Site [chemical binding]; other site 381754013803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3124 381754013804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754013805 dimerization interface [polypeptide binding]; other site 381754013806 putative DNA binding site [nucleotide binding]; other site 381754013807 putative Zn2+ binding site [ion binding]; other site 381754013808 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 381754013809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754013810 putative substrate translocation pore; other site 381754013811 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 381754013812 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 381754013813 FMN binding site [chemical binding]; other site 381754013814 active site 381754013815 substrate binding site [chemical binding]; other site 381754013816 catalytic residue [active] 381754013817 FeoC like transcriptional regulator; Region: FeoC; cl17677 381754013818 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 381754013819 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 381754013820 G1 box; other site 381754013821 GTP/Mg2+ binding site [chemical binding]; other site 381754013822 Switch I region; other site 381754013823 G2 box; other site 381754013824 G3 box; other site 381754013825 Switch II region; other site 381754013826 G4 box; other site 381754013827 G5 box; other site 381754013828 Nucleoside recognition; Region: Gate; pfam07670 381754013829 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 381754013830 Nucleoside recognition; Region: Gate; pfam07670 381754013831 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 381754013832 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 381754013833 oligomer interface [polypeptide binding]; other site 381754013834 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 381754013835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754013836 NAD(P) binding site [chemical binding]; other site 381754013837 active site 381754013838 Uncharacterized conserved protein [Function unknown]; Region: COG3268 381754013839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754013840 NAD(P) binding site [chemical binding]; other site 381754013841 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 381754013842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754013843 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754013844 dimerization interface [polypeptide binding]; other site 381754013845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 381754013846 ACT domain; Region: ACT_3; pfam10000 381754013847 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 381754013848 LysE type translocator; Region: LysE; cl00565 381754013849 superoxide dismutase; Provisional; Region: PRK10543 381754013850 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 381754013851 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 381754013852 biofilm formation regulator HmsP; Provisional; Region: PRK11829 381754013853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754013854 metal binding site [ion binding]; metal-binding site 381754013855 active site 381754013856 I-site; other site 381754013857 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754013858 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 381754013859 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 381754013860 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 381754013861 Imelysin; Region: Peptidase_M75; cl09159 381754013862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 381754013863 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754013864 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754013865 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754013866 multidrug efflux protein; Reviewed; Region: PRK09579 381754013867 Protein export membrane protein; Region: SecD_SecF; cl14618 381754013868 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 381754013869 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 381754013870 active site 381754013871 putative transposase OrfB; Reviewed; Region: PHA02517 381754013872 Integrase core domain; Region: rve; pfam00665 381754013873 Integrase core domain; Region: rve_3; pfam13683 381754013874 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 381754013875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754013876 S-adenosylmethionine binding site [chemical binding]; other site 381754013877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754013878 HAMP domain; Region: HAMP; pfam00672 381754013879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754013880 dimer interface [polypeptide binding]; other site 381754013881 phosphorylation site [posttranslational modification] 381754013882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754013883 ATP binding site [chemical binding]; other site 381754013884 Mg2+ binding site [ion binding]; other site 381754013885 G-X-G motif; other site 381754013886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381754013887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754013888 active site 381754013889 phosphorylation site [posttranslational modification] 381754013890 intermolecular recognition site; other site 381754013891 dimerization interface [polypeptide binding]; other site 381754013892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754013893 DNA binding site [nucleotide binding] 381754013894 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 381754013895 active site 381754013896 chromosome condensation membrane protein; Provisional; Region: PRK14196 381754013897 Putative ParB-like nuclease; Region: ParBc_2; cl17538 381754013898 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 381754013899 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 381754013900 ring oligomerisation interface [polypeptide binding]; other site 381754013901 ATP/Mg binding site [chemical binding]; other site 381754013902 stacking interactions; other site 381754013903 hinge regions; other site 381754013904 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 381754013905 oligomerisation interface [polypeptide binding]; other site 381754013906 mobile loop; other site 381754013907 roof hairpin; other site 381754013908 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 381754013909 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 381754013910 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 381754013911 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 381754013912 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 381754013913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754013914 NAD(P) binding site [chemical binding]; other site 381754013915 active site 381754013916 Protein of unknown function, DUF481; Region: DUF481; pfam04338 381754013917 Protein of unknown function, DUF481; Region: DUF481; pfam04338 381754013918 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 381754013919 DNA binding site [nucleotide binding] 381754013920 active site 381754013921 muropeptide transporter; Validated; Region: ampG; cl17669 381754013922 muropeptide transporter; Validated; Region: ampG; cl17669 381754013923 mechanosensitive channel MscS; Provisional; Region: PRK10334 381754013924 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381754013925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 381754013926 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 381754013927 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381754013928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754013929 active site 381754013930 phosphorylation site [posttranslational modification] 381754013931 intermolecular recognition site; other site 381754013932 dimerization interface [polypeptide binding]; other site 381754013933 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 381754013934 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 381754013935 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 381754013936 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 381754013937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754013938 dimerization interface [polypeptide binding]; other site 381754013939 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 381754013940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754013941 putative active site [active] 381754013942 heme pocket [chemical binding]; other site 381754013943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754013944 dimer interface [polypeptide binding]; other site 381754013945 phosphorylation site [posttranslational modification] 381754013946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754013947 ATP binding site [chemical binding]; other site 381754013948 Mg2+ binding site [ion binding]; other site 381754013949 G-X-G motif; other site 381754013950 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 381754013951 hypothetical protein; Provisional; Region: PRK08999 381754013952 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 381754013953 active site 381754013954 8-oxo-dGMP binding site [chemical binding]; other site 381754013955 nudix motif; other site 381754013956 metal binding site [ion binding]; metal-binding site 381754013957 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 381754013958 thiamine phosphate binding site [chemical binding]; other site 381754013959 active site 381754013960 pyrophosphate binding site [ion binding]; other site 381754013961 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 381754013962 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 381754013963 putative C-terminal domain interface [polypeptide binding]; other site 381754013964 putative GSH binding site (G-site) [chemical binding]; other site 381754013965 putative dimer interface [polypeptide binding]; other site 381754013966 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 381754013967 putative substrate binding pocket (H-site) [chemical binding]; other site 381754013968 putative N-terminal domain interface [polypeptide binding]; other site 381754013969 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 381754013970 heterotetramer interface [polypeptide binding]; other site 381754013971 active site pocket [active] 381754013972 cleavage site 381754013973 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 381754013974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 381754013975 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 381754013976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 381754013977 nucleotide binding region [chemical binding]; other site 381754013978 ATP-binding site [chemical binding]; other site 381754013979 SEC-C motif; Region: SEC-C; pfam02810 381754013980 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 381754013981 Peptidase family M23; Region: Peptidase_M23; pfam01551 381754013982 Protein of unknown function (DUF721); Region: DUF721; cl02324 381754013983 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 381754013984 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 381754013985 cell division protein FtsZ; Validated; Region: PRK09330 381754013986 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 381754013987 nucleotide binding site [chemical binding]; other site 381754013988 SulA interaction site; other site 381754013989 cell division protein FtsA; Region: ftsA; TIGR01174 381754013990 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 381754013991 nucleotide binding site [chemical binding]; other site 381754013992 Cell division protein FtsA; Region: FtsA; pfam14450 381754013993 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 381754013994 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 381754013995 Cell division protein FtsQ; Region: FtsQ; pfam03799 381754013996 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 381754013997 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 381754013998 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754013999 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 381754014000 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 381754014001 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381754014002 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381754014003 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 381754014004 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 381754014005 active site 381754014006 homodimer interface [polypeptide binding]; other site 381754014007 cell division protein FtsW; Region: ftsW; TIGR02614 381754014008 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 381754014009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754014010 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381754014011 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 381754014012 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 381754014013 Mg++ binding site [ion binding]; other site 381754014014 putative catalytic motif [active] 381754014015 putative substrate binding site [chemical binding]; other site 381754014016 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 381754014017 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 381754014018 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381754014019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381754014020 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 381754014021 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 381754014022 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381754014023 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381754014024 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 381754014025 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 381754014026 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 381754014027 Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116 381754014028 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 381754014029 MraW methylase family; Region: Methyltransf_5; cl17771 381754014030 cell division protein MraZ; Reviewed; Region: PRK00326 381754014031 MraZ protein; Region: MraZ; pfam02381 381754014032 MraZ protein; Region: MraZ; pfam02381 381754014033 Predicted methyltransferases [General function prediction only]; Region: COG0313 381754014034 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 381754014035 putative SAM binding site [chemical binding]; other site 381754014036 putative homodimer interface [polypeptide binding]; other site 381754014037 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 381754014038 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 381754014039 putative ligand binding site [chemical binding]; other site 381754014040 hypothetical protein; Reviewed; Region: PRK12497 381754014041 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 381754014042 dimer interface [polypeptide binding]; other site 381754014043 active site 381754014044 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 381754014045 BON domain; Region: BON; pfam04972 381754014046 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 381754014047 stringent starvation protein A; Provisional; Region: sspA; PRK09481 381754014048 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 381754014049 C-terminal domain interface [polypeptide binding]; other site 381754014050 putative GSH binding site (G-site) [chemical binding]; other site 381754014051 dimer interface [polypeptide binding]; other site 381754014052 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 381754014053 dimer interface [polypeptide binding]; other site 381754014054 N-terminal domain interface [polypeptide binding]; other site 381754014055 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 381754014056 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 381754014057 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 381754014058 Qi binding site; other site 381754014059 intrachain domain interface; other site 381754014060 interchain domain interface [polypeptide binding]; other site 381754014061 heme bH binding site [chemical binding]; other site 381754014062 heme bL binding site [chemical binding]; other site 381754014063 Qo binding site; other site 381754014064 interchain domain interface [polypeptide binding]; other site 381754014065 intrachain domain interface; other site 381754014066 Qi binding site; other site 381754014067 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 381754014068 Qo binding site; other site 381754014069 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 381754014070 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 381754014071 [2Fe-2S] cluster binding site [ion binding]; other site 381754014072 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 381754014073 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 381754014074 23S rRNA interface [nucleotide binding]; other site 381754014075 L3 interface [polypeptide binding]; other site 381754014076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 381754014077 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 381754014078 active site 381754014079 catalytic tetrad [active] 381754014080 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754014081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754014082 active site 381754014083 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 381754014084 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 381754014085 conserved cys residue [active] 381754014086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754014087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754014088 Predicted ATPase [General function prediction only]; Region: COG1485 381754014089 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 381754014090 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 381754014091 active site 381754014092 HIGH motif; other site 381754014093 dimer interface [polypeptide binding]; other site 381754014094 KMSKS motif; other site 381754014095 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 381754014096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 381754014097 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 381754014098 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 381754014099 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 381754014100 CysD dimerization site [polypeptide binding]; other site 381754014101 G1 box; other site 381754014102 putative GEF interaction site [polypeptide binding]; other site 381754014103 GTP/Mg2+ binding site [chemical binding]; other site 381754014104 Switch I region; other site 381754014105 G2 box; other site 381754014106 G3 box; other site 381754014107 Switch II region; other site 381754014108 G4 box; other site 381754014109 G5 box; other site 381754014110 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 381754014111 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 381754014112 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 381754014113 ligand-binding site [chemical binding]; other site 381754014114 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 381754014115 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 381754014116 Active Sites [active] 381754014117 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 381754014118 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381754014119 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381754014120 catalytic residue [active] 381754014121 Uncharacterized conserved protein [Function unknown]; Region: COG0327 381754014122 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 381754014123 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 381754014124 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 381754014125 protein binding site [polypeptide binding]; other site 381754014126 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 381754014127 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754014128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754014129 homodimer interface [polypeptide binding]; other site 381754014130 catalytic residue [active] 381754014131 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 381754014132 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 381754014133 NAD binding site [chemical binding]; other site 381754014134 dimerization interface [polypeptide binding]; other site 381754014135 product binding site; other site 381754014136 substrate binding site [chemical binding]; other site 381754014137 zinc binding site [ion binding]; other site 381754014138 catalytic residues [active] 381754014139 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 381754014140 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 381754014141 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 381754014142 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 381754014143 hinge; other site 381754014144 active site 381754014145 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 381754014146 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 381754014147 anti sigma factor interaction site; other site 381754014148 regulatory phosphorylation site [posttranslational modification]; other site 381754014149 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 381754014150 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 381754014151 mce related protein; Region: MCE; pfam02470 381754014152 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 381754014153 conserved hypothetical integral membrane protein; Region: TIGR00056 381754014154 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 381754014155 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 381754014156 Walker A/P-loop; other site 381754014157 ATP binding site [chemical binding]; other site 381754014158 Q-loop/lid; other site 381754014159 ABC transporter signature motif; other site 381754014160 Walker B; other site 381754014161 D-loop; other site 381754014162 H-loop/switch region; other site 381754014163 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 381754014164 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 381754014165 putative active site [active] 381754014166 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 381754014167 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 381754014168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754014169 active site 381754014170 motif I; other site 381754014171 motif II; other site 381754014172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 381754014173 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 381754014174 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 381754014175 OstA-like protein; Region: OstA; pfam03968 381754014176 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 381754014177 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 381754014178 Walker A/P-loop; other site 381754014179 ATP binding site [chemical binding]; other site 381754014180 Q-loop/lid; other site 381754014181 ABC transporter signature motif; other site 381754014182 Walker B; other site 381754014183 D-loop; other site 381754014184 H-loop/switch region; other site 381754014185 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 381754014186 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 381754014187 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 381754014188 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 381754014189 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 381754014190 30S subunit binding site; other site 381754014191 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 381754014192 active site 381754014193 phosphorylation site [posttranslational modification] 381754014194 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 381754014195 AAA domain; Region: AAA_18; pfam13238 381754014196 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 381754014197 dimerization domain swap beta strand [polypeptide binding]; other site 381754014198 regulatory protein interface [polypeptide binding]; other site 381754014199 active site 381754014200 regulatory phosphorylation site [posttranslational modification]; other site 381754014201 integrase; Provisional; Region: int; PHA02601 381754014202 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754014203 active site 381754014204 DNA binding site [nucleotide binding] 381754014205 Int/Topo IB signature motif; other site 381754014206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754014207 non-specific DNA binding site [nucleotide binding]; other site 381754014208 salt bridge; other site 381754014209 sequence-specific DNA binding site [nucleotide binding]; other site 381754014210 stomagen; Provisional; Region: PLN03207 381754014211 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 381754014212 active site 381754014213 metal binding site [ion binding]; metal-binding site 381754014214 interdomain interaction site; other site 381754014215 Phage-related protein [Function unknown]; Region: COG4695; cl01923 381754014216 Phage portal protein; Region: Phage_portal; pfam04860 381754014217 terminase ATPase subunit; Provisional; Region: P; PHA02535 381754014218 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 381754014219 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 381754014220 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 381754014221 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 381754014222 terminase endonuclease subunit; Provisional; Region: M; PHA02537 381754014223 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 381754014224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 381754014225 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 381754014226 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 381754014227 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 381754014228 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 381754014229 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 381754014230 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 381754014231 catalytic residues [active] 381754014232 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 381754014233 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 381754014234 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 381754014235 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 381754014236 Baseplate J-like protein; Region: Baseplate_J; cl01294 381754014237 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 381754014238 Phage Tail Collar Domain; Region: Collar; pfam07484 381754014239 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 381754014240 YcfA-like protein; Region: YcfA; pfam07927 381754014241 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 381754014242 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 381754014243 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 381754014244 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 381754014245 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 381754014246 fumarate hydratase; Reviewed; Region: fumC; PRK00485 381754014247 Class II fumarases; Region: Fumarase_classII; cd01362 381754014248 active site 381754014249 tetramer interface [polypeptide binding]; other site 381754014250 peptidase PmbA; Provisional; Region: PRK11040 381754014251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 381754014252 protease TldD; Provisional; Region: tldD; PRK10735 381754014253 nitrilase; Region: PLN02798 381754014254 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 381754014255 putative active site [active] 381754014256 catalytic triad [active] 381754014257 dimer interface [polypeptide binding]; other site 381754014258 Predicted membrane protein [Function unknown]; Region: COG3164 381754014259 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 381754014260 ribonuclease G; Provisional; Region: PRK11712 381754014261 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 381754014262 homodimer interface [polypeptide binding]; other site 381754014263 oligonucleotide binding site [chemical binding]; other site 381754014264 Maf-like protein; Region: Maf; pfam02545 381754014265 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 381754014266 active site 381754014267 dimer interface [polypeptide binding]; other site 381754014268 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 381754014269 rod shape-determining protein MreC; Provisional; Region: PRK13922 381754014270 rod shape-determining protein MreC; Region: MreC; pfam04085 381754014271 rod shape-determining protein MreB; Provisional; Region: PRK13927 381754014272 MreB and similar proteins; Region: MreB_like; cd10225 381754014273 nucleotide binding site [chemical binding]; other site 381754014274 Mg binding site [ion binding]; other site 381754014275 putative protofilament interaction site [polypeptide binding]; other site 381754014276 RodZ interaction site [polypeptide binding]; other site 381754014277 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 381754014278 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 381754014279 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 381754014280 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 381754014281 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 381754014282 GatB domain; Region: GatB_Yqey; smart00845 381754014283 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 381754014284 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 381754014285 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 381754014286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 381754014287 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 381754014288 Predicted secreted protein [Function unknown]; Region: COG5445 381754014289 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 381754014290 Predicted secreted protein [Function unknown]; Region: COG5445 381754014291 Stage II sporulation protein; Region: SpoIID; pfam08486 381754014292 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 381754014293 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 381754014294 MG2 domain; Region: A2M_N; pfam01835 381754014295 Alpha-2-macroglobulin family; Region: A2M; pfam00207 381754014296 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 381754014297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 381754014298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 381754014299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 381754014300 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 381754014301 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 381754014302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754014303 active site 381754014304 phosphorylation site [posttranslational modification] 381754014305 intermolecular recognition site; other site 381754014306 dimerization interface [polypeptide binding]; other site 381754014307 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754014308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754014309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754014310 phosphorylation site [posttranslational modification] 381754014311 dimer interface [polypeptide binding]; other site 381754014312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754014313 ATP binding site [chemical binding]; other site 381754014314 G-X-G motif; other site 381754014315 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 381754014316 Uncharacterized conserved protein [Function unknown]; Region: COG2968 381754014317 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381754014318 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 381754014319 peptide binding site [polypeptide binding]; other site 381754014320 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381754014321 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 381754014322 peptide binding site [polypeptide binding]; other site 381754014323 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 381754014324 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 381754014325 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 381754014326 active site 381754014327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754014328 non-specific DNA binding site [nucleotide binding]; other site 381754014329 salt bridge; other site 381754014330 sequence-specific DNA binding site [nucleotide binding]; other site 381754014331 Cupin domain; Region: Cupin_2; pfam07883 381754014332 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381754014333 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 381754014334 peptide binding site [polypeptide binding]; other site 381754014335 outer membrane porin, OprD family; Region: OprD; pfam03573 381754014336 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 381754014337 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381754014338 peptide binding site [polypeptide binding]; other site 381754014339 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 381754014340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754014341 dimer interface [polypeptide binding]; other site 381754014342 conserved gate region; other site 381754014343 putative PBP binding loops; other site 381754014344 ABC-ATPase subunit interface; other site 381754014345 dipeptide transporter; Provisional; Region: PRK10913 381754014346 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 381754014347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754014348 putative PBP binding loops; other site 381754014349 dimer interface [polypeptide binding]; other site 381754014350 ABC-ATPase subunit interface; other site 381754014351 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 381754014352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381754014353 Walker A/P-loop; other site 381754014354 ATP binding site [chemical binding]; other site 381754014355 Q-loop/lid; other site 381754014356 ABC transporter signature motif; other site 381754014357 Walker B; other site 381754014358 D-loop; other site 381754014359 H-loop/switch region; other site 381754014360 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 381754014361 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 381754014362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381754014363 Walker A/P-loop; other site 381754014364 ATP binding site [chemical binding]; other site 381754014365 Q-loop/lid; other site 381754014366 ABC transporter signature motif; other site 381754014367 Walker B; other site 381754014368 D-loop; other site 381754014369 H-loop/switch region; other site 381754014370 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 381754014371 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754014372 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754014373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754014374 putative DNA binding site [nucleotide binding]; other site 381754014375 putative Zn2+ binding site [ion binding]; other site 381754014376 AsnC family; Region: AsnC_trans_reg; pfam01037 381754014377 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 381754014378 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 381754014379 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 381754014380 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 381754014381 putative active site [active] 381754014382 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 381754014383 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 381754014384 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 381754014385 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 381754014386 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 381754014387 Flavodoxin; Region: Flavodoxin_1; pfam00258 381754014388 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 381754014389 FAD binding pocket [chemical binding]; other site 381754014390 FAD binding motif [chemical binding]; other site 381754014391 catalytic residues [active] 381754014392 NAD binding pocket [chemical binding]; other site 381754014393 phosphate binding motif [ion binding]; other site 381754014394 beta-alpha-beta structure motif; other site 381754014395 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 381754014396 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754014397 N-terminal plug; other site 381754014398 ligand-binding site [chemical binding]; other site 381754014399 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 381754014400 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 381754014401 Sel1-like repeats; Region: SEL1; smart00671 381754014402 Sel1-like repeats; Region: SEL1; smart00671 381754014403 hypothetical protein; Provisional; Region: PRK10649 381754014404 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 381754014405 Sulfatase; Region: Sulfatase; pfam00884 381754014406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754014407 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 381754014408 putative transposase OrfB; Reviewed; Region: PHA02517 381754014409 Integrase core domain; Region: rve; pfam00665 381754014410 Integrase core domain; Region: rve_3; pfam13683 381754014411 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 381754014412 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 381754014413 dimer interface [polypeptide binding]; other site 381754014414 active site 381754014415 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381754014416 catalytic residues [active] 381754014417 substrate binding site [chemical binding]; other site 381754014418 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 381754014419 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754014420 dimerization interface [polypeptide binding]; other site 381754014421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754014422 dimer interface [polypeptide binding]; other site 381754014423 putative CheW interface [polypeptide binding]; other site 381754014424 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 381754014425 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 381754014426 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 381754014427 amidase catalytic site [active] 381754014428 Zn binding residues [ion binding]; other site 381754014429 substrate binding site [chemical binding]; other site 381754014430 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 381754014431 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 381754014432 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 381754014433 dimerization interface [polypeptide binding]; other site 381754014434 active site 381754014435 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 381754014436 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754014437 active site 381754014438 DNA binding site [nucleotide binding] 381754014439 Int/Topo IB signature motif; other site 381754014440 Helix-turn-helix domain; Region: HTH_17; pfam12728 381754014441 Helix-turn-helix domain; Region: HTH_39; pfam14090 381754014442 MarR family; Region: MarR_2; pfam12802 381754014443 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 381754014444 Phage capsid family; Region: Phage_capsid; pfam05065 381754014445 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 381754014446 Phage-related protein [Function unknown]; Region: COG4695 381754014447 Phage portal protein; Region: Phage_portal; pfam04860 381754014448 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 381754014449 active site 381754014450 large terminase protein; Provisional; Region: 17; PHA02533 381754014451 Phage Terminase; Region: Terminase_1; pfam03354 381754014452 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 381754014453 oligomerization interface [polypeptide binding]; other site 381754014454 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 381754014455 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 381754014456 Pilin (bacterial filament); Region: Pilin; pfam00114 381754014457 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 381754014458 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 381754014459 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 381754014460 Walker A motif; other site 381754014461 ATP binding site [chemical binding]; other site 381754014462 Walker B motif; other site 381754014463 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 381754014464 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754014465 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381754014466 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 381754014467 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 381754014468 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 381754014469 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 381754014470 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 381754014471 CoA-binding site [chemical binding]; other site 381754014472 ATP-binding [chemical binding]; other site 381754014473 DNA gyrase inhibitor; Reviewed; Region: PRK00418 381754014474 Predicted membrane protein [Function unknown]; Region: COG3235 381754014475 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 381754014476 putative acetyltransferase; Provisional; Region: PRK03624 381754014477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 381754014478 Coenzyme A binding pocket [chemical binding]; other site 381754014479 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 381754014480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 381754014481 MOSC domain; Region: MOSC; pfam03473 381754014482 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 381754014483 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 381754014484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754014485 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 381754014486 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 381754014487 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 381754014488 Surface antigen; Region: Bac_surface_Ag; pfam01103 381754014489 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 381754014490 haemagglutination activity domain; Region: Haemagg_act; pfam05860 381754014491 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 381754014492 Clp amino terminal domain; Region: Clp_N; pfam02861 381754014493 Clp amino terminal domain; Region: Clp_N; pfam02861 381754014494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754014495 Walker A motif; other site 381754014496 ATP binding site [chemical binding]; other site 381754014497 Walker B motif; other site 381754014498 arginine finger; other site 381754014499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754014500 Walker A motif; other site 381754014501 ATP binding site [chemical binding]; other site 381754014502 Walker B motif; other site 381754014503 arginine finger; other site 381754014504 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 381754014505 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 381754014506 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 381754014507 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 381754014508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381754014509 RNA binding surface [nucleotide binding]; other site 381754014510 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 381754014511 active site 381754014512 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 381754014513 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 381754014514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754014515 dimer interface [polypeptide binding]; other site 381754014516 phosphorylation site [posttranslational modification] 381754014517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754014518 ATP binding site [chemical binding]; other site 381754014519 Mg2+ binding site [ion binding]; other site 381754014520 G-X-G motif; other site 381754014521 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754014522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754014523 active site 381754014524 phosphorylation site [posttranslational modification] 381754014525 intermolecular recognition site; other site 381754014526 dimerization interface [polypeptide binding]; other site 381754014527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754014528 Walker A motif; other site 381754014529 ATP binding site [chemical binding]; other site 381754014530 Walker B motif; other site 381754014531 arginine finger; other site 381754014532 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754014533 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 381754014534 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 381754014535 Type II transport protein GspH; Region: GspH; pfam12019 381754014536 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 381754014537 Type II transport protein GspH; Region: GspH; pfam12019 381754014538 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 381754014539 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 381754014540 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 381754014541 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 381754014542 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 381754014543 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 381754014544 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 381754014545 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 381754014546 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 381754014547 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 381754014548 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 381754014549 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 381754014550 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 381754014551 lipoprotein signal peptidase; Provisional; Region: PRK14787 381754014552 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 381754014553 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 381754014554 active site 381754014555 HIGH motif; other site 381754014556 nucleotide binding site [chemical binding]; other site 381754014557 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 381754014558 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 381754014559 active site 381754014560 KMSKS motif; other site 381754014561 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 381754014562 tRNA binding surface [nucleotide binding]; other site 381754014563 anticodon binding site; other site 381754014564 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 381754014565 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 381754014566 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 381754014567 active site 381754014568 Riboflavin kinase; Region: Flavokinase; smart00904 381754014569 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 381754014570 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 381754014571 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 381754014572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 381754014573 CreA protein; Region: CreA; pfam05981 381754014574 gamma-glutamyl kinase; Provisional; Region: PRK05429 381754014575 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 381754014576 nucleotide binding site [chemical binding]; other site 381754014577 homotetrameric interface [polypeptide binding]; other site 381754014578 putative phosphate binding site [ion binding]; other site 381754014579 putative allosteric binding site; other site 381754014580 PUA domain; Region: PUA; pfam01472 381754014581 GTPase CgtA; Reviewed; Region: obgE; PRK12298 381754014582 GTP1/OBG; Region: GTP1_OBG; pfam01018 381754014583 Obg GTPase; Region: Obg; cd01898 381754014584 G1 box; other site 381754014585 GTP/Mg2+ binding site [chemical binding]; other site 381754014586 Switch I region; other site 381754014587 G2 box; other site 381754014588 G3 box; other site 381754014589 Switch II region; other site 381754014590 G4 box; other site 381754014591 G5 box; other site 381754014592 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 381754014593 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 381754014594 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 381754014595 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 381754014596 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 381754014597 substrate binding pocket [chemical binding]; other site 381754014598 chain length determination region; other site 381754014599 substrate-Mg2+ binding site; other site 381754014600 catalytic residues [active] 381754014601 aspartate-rich region 1; other site 381754014602 active site lid residues [active] 381754014603 aspartate-rich region 2; other site 381754014604 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754014605 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754014606 Cytochrome c; Region: Cytochrom_C; pfam00034 381754014607 Cytochrome c [Energy production and conversion]; Region: COG3258 381754014608 Cytochrome c; Region: Cytochrom_C; pfam00034 381754014609 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 381754014610 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 381754014611 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 381754014612 hypothetical protein; Provisional; Region: PRK05208 381754014613 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 381754014614 AAA domain; Region: AAA_32; pfam13654 381754014615 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 381754014616 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 381754014617 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 381754014618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 381754014619 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 381754014620 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 381754014621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754014622 Walker A motif; other site 381754014623 ATP binding site [chemical binding]; other site 381754014624 Walker B motif; other site 381754014625 arginine finger; other site 381754014626 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 381754014627 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 381754014628 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 381754014629 hypothetical protein; Reviewed; Region: PRK09588 381754014630 HEAT repeats; Region: HEAT_2; pfam13646 381754014631 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 381754014632 glutamate dehydrogenase; Provisional; Region: PRK09414 381754014633 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 381754014634 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 381754014635 NAD(P) binding site [chemical binding]; other site 381754014636 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 381754014637 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 381754014638 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754014639 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754014640 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 381754014641 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 381754014642 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 381754014643 FtsX-like permease family; Region: FtsX; pfam02687 381754014644 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 381754014645 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 381754014646 Walker A/P-loop; other site 381754014647 ATP binding site [chemical binding]; other site 381754014648 Q-loop/lid; other site 381754014649 ABC transporter signature motif; other site 381754014650 Walker B; other site 381754014651 D-loop; other site 381754014652 H-loop/switch region; other site 381754014653 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 381754014654 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754014655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754014656 ABC transporter; Region: ABC_tran_2; pfam12848 381754014657 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754014658 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 381754014659 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 381754014660 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 381754014661 Protein export membrane protein; Region: SecD_SecF; cl14618 381754014662 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 381754014663 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754014664 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754014665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 381754014666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754014667 PAS domain; Region: PAS_9; pfam13426 381754014668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754014669 PAS fold; Region: PAS_3; pfam08447 381754014670 putative active site [active] 381754014671 heme pocket [chemical binding]; other site 381754014672 PAS domain S-box; Region: sensory_box; TIGR00229 381754014673 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 381754014674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754014675 PAS domain; Region: PAS_9; pfam13426 381754014676 putative active site [active] 381754014677 heme pocket [chemical binding]; other site 381754014678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754014679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754014680 metal binding site [ion binding]; metal-binding site 381754014681 active site 381754014682 I-site; other site 381754014683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754014684 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 381754014685 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 381754014686 dimer interface [polypeptide binding]; other site 381754014687 active site 381754014688 glycine-pyridoxal phosphate binding site [chemical binding]; other site 381754014689 folate binding site [chemical binding]; other site 381754014690 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 381754014691 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 381754014692 P-loop, Walker A motif; other site 381754014693 Base recognition motif; other site 381754014694 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 381754014695 Uncharacterized small protein [Function unknown]; Region: COG2879 381754014696 carbon starvation protein A; Provisional; Region: PRK15015 381754014697 Carbon starvation protein CstA; Region: CstA; pfam02554 381754014698 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 381754014699 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 381754014700 PilZ domain; Region: PilZ; pfam07238 381754014701 DNA repair protein RadA; Provisional; Region: PRK11823 381754014702 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 381754014703 Walker A motif/ATP binding site; other site 381754014704 ATP binding site [chemical binding]; other site 381754014705 Walker B motif; other site 381754014706 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 381754014707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 381754014708 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 381754014709 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 381754014710 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 381754014711 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 381754014712 tetramer interface [polypeptide binding]; other site 381754014713 heme binding pocket [chemical binding]; other site 381754014714 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 381754014715 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 381754014716 tetramer interface [polypeptide binding]; other site 381754014717 heme binding pocket [chemical binding]; other site 381754014718 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 381754014719 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 381754014720 Integrase core domain; Region: rve; pfam00665 381754014721 Integrase core domain; Region: rve_3; pfam13683 381754014722 putative transposase OrfB; Reviewed; Region: PHA02517 381754014723 Integrase core domain; Region: rve; pfam00665 381754014724 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 381754014725 ferredoxin-NADP reductase; Provisional; Region: PRK10926 381754014726 FAD binding pocket [chemical binding]; other site 381754014727 FAD binding motif [chemical binding]; other site 381754014728 phosphate binding motif [ion binding]; other site 381754014729 beta-alpha-beta structure motif; other site 381754014730 NAD binding pocket [chemical binding]; other site 381754014731 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 381754014732 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 381754014733 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 381754014734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754014735 S-adenosylmethionine binding site [chemical binding]; other site 381754014736 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 381754014737 Ligand binding site; other site 381754014738 metal-binding site 381754014739 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 381754014740 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 381754014741 XdhC Rossmann domain; Region: XdhC_C; pfam13478 381754014742 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754014743 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754014744 Cytochrome c; Region: Cytochrom_C; pfam00034 381754014745 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 381754014746 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 381754014747 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 381754014748 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754014749 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 381754014750 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 381754014751 H+ Antiporter protein; Region: 2A0121; TIGR00900 381754014752 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 381754014753 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 381754014754 haemagglutination activity domain; Region: Haemagg_act; pfam05860 381754014755 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 381754014756 glycerate dehydrogenase; Provisional; Region: PRK06487 381754014757 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 381754014758 putative ligand binding site [chemical binding]; other site 381754014759 putative NAD binding site [chemical binding]; other site 381754014760 catalytic site [active] 381754014761 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 381754014762 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 381754014763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754014764 S-adenosylmethionine binding site [chemical binding]; other site 381754014765 lysine transporter; Provisional; Region: PRK10836 381754014766 Predicted membrane protein [Function unknown]; Region: COG2119 381754014767 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 381754014768 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 381754014769 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 381754014770 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 381754014771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754014772 NAD(P) binding site [chemical binding]; other site 381754014773 active site 381754014774 Peptidase family M48; Region: Peptidase_M48; pfam01435 381754014775 Cache domain; Region: Cache_1; pfam02743 381754014776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754014777 dimerization interface [polypeptide binding]; other site 381754014778 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754014779 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754014780 dimer interface [polypeptide binding]; other site 381754014781 putative CheW interface [polypeptide binding]; other site 381754014782 Uncharacterized conserved protein [Function unknown]; Region: COG2135 381754014783 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 381754014784 MgtC family; Region: MgtC; pfam02308 381754014785 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 381754014786 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 381754014787 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 381754014788 putative acyl-acceptor binding pocket; other site 381754014789 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 381754014790 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 381754014791 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 381754014792 dimer interface [polypeptide binding]; other site 381754014793 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754014794 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 381754014795 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754014796 active site 381754014797 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754014798 active site 381754014799 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 381754014800 Uncharacterized secreted protein [Function unknown]; Region: COG5430 381754014801 Uncharacterized secreted protein [Function unknown]; Region: COG5430 381754014802 Uncharacterized secreted protein [Function unknown]; Region: COG5430 381754014803 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 381754014804 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 381754014805 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 381754014806 PapC N-terminal domain; Region: PapC_N; pfam13954 381754014807 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 381754014808 PapC C-terminal domain; Region: PapC_C; pfam13953 381754014809 Spore Coat Protein U domain; Region: SCPU; pfam05229 381754014810 Uncharacterized secreted protein [Function unknown]; Region: COG5430 381754014811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754014812 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754014813 putative substrate translocation pore; other site 381754014814 ferrochelatase; Reviewed; Region: hemH; PRK00035 381754014815 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 381754014816 C-terminal domain interface [polypeptide binding]; other site 381754014817 active site 381754014818 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 381754014819 active site 381754014820 N-terminal domain interface [polypeptide binding]; other site 381754014821 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 381754014822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754014823 NAD(P) binding site [chemical binding]; other site 381754014824 active site 381754014825 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 381754014826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381754014827 Protein of unknown function (DUF523); Region: DUF523; pfam04463 381754014828 Uncharacterized conserved protein [Function unknown]; Region: COG3272 381754014829 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 381754014830 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 381754014831 DNA binding residues [nucleotide binding] 381754014832 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 381754014833 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 381754014834 DNA photolyase; Region: DNA_photolyase; pfam00875 381754014835 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 381754014836 glutamate racemase; Provisional; Region: PRK00865 381754014837 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 381754014838 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 381754014839 ATP binding site [chemical binding]; other site 381754014840 substrate interface [chemical binding]; other site 381754014841 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 381754014842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754014843 peptide chain release factor 1; Validated; Region: prfA; PRK00591 381754014844 This domain is found in peptide chain release factors; Region: PCRF; smart00937 381754014845 RF-1 domain; Region: RF-1; pfam00472 381754014846 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 381754014847 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 381754014848 tRNA; other site 381754014849 putative tRNA binding site [nucleotide binding]; other site 381754014850 putative NADP binding site [chemical binding]; other site 381754014851 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 381754014852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 381754014853 TPR motif; other site 381754014854 binding surface 381754014855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754014856 binding surface 381754014857 Tetratricopeptide repeat; Region: TPR_16; pfam13432 381754014858 TPR motif; other site 381754014859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754014860 binding surface 381754014861 TPR motif; other site 381754014862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 381754014863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754014864 binding surface 381754014865 TPR motif; other site 381754014866 Tetratricopeptide repeat; Region: TPR_16; pfam13432 381754014867 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 381754014868 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 381754014869 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 381754014870 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 381754014871 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 381754014872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754014873 active site 381754014874 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 381754014875 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 381754014876 5S rRNA interface [nucleotide binding]; other site 381754014877 CTC domain interface [polypeptide binding]; other site 381754014878 L16 interface [polypeptide binding]; other site 381754014879 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 381754014880 putative active site [active] 381754014881 catalytic residue [active] 381754014882 GTP-binding protein YchF; Reviewed; Region: PRK09601 381754014883 YchF GTPase; Region: YchF; cd01900 381754014884 G1 box; other site 381754014885 GTP/Mg2+ binding site [chemical binding]; other site 381754014886 Switch I region; other site 381754014887 G2 box; other site 381754014888 Switch II region; other site 381754014889 G3 box; other site 381754014890 G4 box; other site 381754014891 G5 box; other site 381754014892 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 381754014893 integrase; Provisional; Region: PRK09692 381754014894 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 381754014895 active site 381754014896 Int/Topo IB signature motif; other site 381754014897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754014898 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 381754014899 Walker A motif; other site 381754014900 ATP binding site [chemical binding]; other site 381754014901 Walker B motif; other site 381754014902 arginine finger; other site 381754014903 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 381754014904 active site 381754014905 catalytic triad [active] 381754014906 Abortive infection C-terminus; Region: Abi_C; pfam14355 381754014907 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 381754014908 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 381754014909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754014910 ATP binding site [chemical binding]; other site 381754014911 putative Mg++ binding site [ion binding]; other site 381754014912 Pseudomurein-binding repeat; Region: PMBR; pfam09373 381754014913 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 381754014914 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 381754014915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 381754014916 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 381754014917 Integrase core domain; Region: rve; pfam00665 381754014918 Resolvase, N terminal domain; Region: Resolvase; pfam00239 381754014919 catalytic residues [active] 381754014920 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 381754014921 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 381754014922 DNA-binding interface [nucleotide binding]; DNA binding site 381754014923 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 381754014924 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 381754014925 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 381754014926 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 381754014927 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 381754014928 catalytic residues [active] 381754014929 catalytic nucleophile [active] 381754014930 Presynaptic Site I dimer interface [polypeptide binding]; other site 381754014931 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 381754014932 Synaptic Flat tetramer interface [polypeptide binding]; other site 381754014933 Synaptic Site I dimer interface [polypeptide binding]; other site 381754014934 DNA binding site [nucleotide binding] 381754014935 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 381754014936 DNA-binding interface [nucleotide binding]; DNA binding site 381754014937 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 381754014938 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 381754014939 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 381754014940 dihydropteroate synthase; Region: DHPS; TIGR01496 381754014941 substrate binding pocket [chemical binding]; other site 381754014942 dimer interface [polypeptide binding]; other site 381754014943 inhibitor binding site; inhibition site 381754014944 integrase/recombinase; Provisional; Region: PRK15417 381754014945 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 381754014946 Int/Topo IB signature motif; other site 381754014947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 381754014948 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 381754014949 Integrase core domain; Region: rve; pfam00665 381754014950 MobA/MobL family; Region: MobA_MobL; pfam03389 381754014951 Conjugal transfer protein TraD; Region: TraD; pfam06412 381754014952 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 381754014953 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 381754014954 TrfA protein; Region: TrfA; pfam07042 381754014955 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 381754014956 lipase chaperone; Provisional; Region: PRK01294 381754014957 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 381754014958 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 381754014959 Lipase (class 2); Region: Lipase_2; pfam01674 381754014960 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754014961 Helix-turn-helix domain; Region: HTH_18; pfam12833 381754014962 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 381754014963 putative active site [active] 381754014964 integrase; Provisional; Region: int; PHA02601 381754014965 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754014966 active site 381754014967 DNA binding site [nucleotide binding] 381754014968 Int/Topo IB signature motif; other site 381754014969 Zonula occludens toxin [General function prediction only]; Region: Zot; COG4128 381754014970 putative assembly protein; Region: PHA00350 381754014971 hypothetical protein; Region: PHA01159 381754014972 Phage Coat protein B; Region: Phage_Coat_B; pfam05356 381754014973 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 381754014974 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754014975 P-loop; other site 381754014976 Magnesium ion binding site [ion binding]; other site 381754014977 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754014978 Magnesium ion binding site [ion binding]; other site 381754014979 Restriction endonuclease; Region: Mrr_cat; pfam04471 381754014980 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 381754014981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754014982 non-specific DNA binding site [nucleotide binding]; other site 381754014983 salt bridge; other site 381754014984 sequence-specific DNA binding site [nucleotide binding]; other site 381754014985 Nuclease-related domain; Region: NERD; pfam08378 381754014986 Part of AAA domain; Region: AAA_19; pfam13245 381754014987 Family description; Region: UvrD_C_2; pfam13538 381754014988 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 381754014989 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754014990 N-terminal plug; other site 381754014991 ligand-binding site [chemical binding]; other site 381754014992 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 381754014993 active site clefts [active] 381754014994 zinc binding site [ion binding]; other site 381754014995 dimer interface [polypeptide binding]; other site 381754014996 Peptidase family C69; Region: Peptidase_C69; cl17793 381754014997 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 381754014998 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 381754014999 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 381754015000 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 381754015001 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 381754015002 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 381754015003 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 381754015004 mce related protein; Region: MCE; pfam02470 381754015005 mce related protein; Region: MCE; pfam02470 381754015006 mce related protein; Region: MCE; pfam02470 381754015007 mce related protein; Region: MCE; pfam02470 381754015008 mce related protein; Region: MCE; pfam02470 381754015009 mce related protein; Region: MCE; pfam02470 381754015010 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 381754015011 Paraquat-inducible protein A; Region: PqiA; pfam04403 381754015012 Paraquat-inducible protein A; Region: PqiA; pfam04403 381754015013 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 381754015014 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 381754015015 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 381754015016 Moco binding site; other site 381754015017 metal coordination site [ion binding]; other site 381754015018 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 381754015019 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 381754015020 ketol-acid reductoisomerase; Provisional; Region: PRK05479 381754015021 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 381754015022 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 381754015023 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 381754015024 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 381754015025 putative valine binding site [chemical binding]; other site 381754015026 dimer interface [polypeptide binding]; other site 381754015027 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 381754015028 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 381754015029 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 381754015030 PYR/PP interface [polypeptide binding]; other site 381754015031 dimer interface [polypeptide binding]; other site 381754015032 TPP binding site [chemical binding]; other site 381754015033 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754015034 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 381754015035 TPP-binding site [chemical binding]; other site 381754015036 dimer interface [polypeptide binding]; other site 381754015037 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 381754015038 tRNA pseudouridine synthase C; Region: DUF446; cl01187 381754015039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754015040 TPR motif; other site 381754015041 binding surface 381754015042 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 381754015043 Transglycosylase; Region: Transgly; pfam00912 381754015044 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 381754015045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 381754015046 Predicted kinase [General function prediction only]; Region: COG0645 381754015047 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 381754015048 ATP-binding site [chemical binding]; other site 381754015049 Gluconate-6-phosphate binding site [chemical binding]; other site 381754015050 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 381754015051 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 381754015052 TfoX C-terminal domain; Region: TfoX_C; pfam04994 381754015053 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 381754015054 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 381754015055 ligand binding site [chemical binding]; other site 381754015056 flexible hinge region; other site 381754015057 Protein of unknown function, DUF399; Region: DUF399; cl01139 381754015058 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 381754015059 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 381754015060 Walker A/P-loop; other site 381754015061 ATP binding site [chemical binding]; other site 381754015062 Q-loop/lid; other site 381754015063 ABC transporter signature motif; other site 381754015064 Walker B; other site 381754015065 D-loop; other site 381754015066 H-loop/switch region; other site 381754015067 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 381754015068 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 381754015069 ABC-ATPase subunit interface; other site 381754015070 dimer interface [polypeptide binding]; other site 381754015071 putative PBP binding regions; other site 381754015072 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 381754015073 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 381754015074 putative hemin binding site; other site 381754015075 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 381754015076 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 381754015077 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 381754015078 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 381754015079 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754015080 N-terminal plug; other site 381754015081 ligand-binding site [chemical binding]; other site 381754015082 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 381754015083 iron-sulfur cluster [ion binding]; other site 381754015084 [2Fe-2S] cluster binding site [ion binding]; other site 381754015085 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 381754015086 Predicted metal-binding protein [General function prediction only]; Region: COG3019 381754015087 aminotransferase; Validated; Region: PRK08175 381754015088 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754015089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754015090 homodimer interface [polypeptide binding]; other site 381754015091 catalytic residue [active] 381754015092 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 381754015093 Predicted metalloprotease [General function prediction only]; Region: COG2321 381754015094 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 381754015095 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 381754015096 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 381754015097 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 381754015098 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 381754015099 hypothetical protein; Provisional; Region: PRK08960 381754015100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754015101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754015102 homodimer interface [polypeptide binding]; other site 381754015103 catalytic residue [active] 381754015104 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 381754015105 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 381754015106 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 381754015107 active site 381754015108 HIGH motif; other site 381754015109 nucleotide binding site [chemical binding]; other site 381754015110 KMSKS motif; other site 381754015111 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 381754015112 Na binding site [ion binding]; other site 381754015113 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754015114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 381754015115 putative active site [active] 381754015116 heme pocket [chemical binding]; other site 381754015117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754015118 dimer interface [polypeptide binding]; other site 381754015119 phosphorylation site [posttranslational modification] 381754015120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754015121 ATP binding site [chemical binding]; other site 381754015122 Mg2+ binding site [ion binding]; other site 381754015123 G-X-G motif; other site 381754015124 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754015125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754015126 active site 381754015127 phosphorylation site [posttranslational modification] 381754015128 intermolecular recognition site; other site 381754015129 dimerization interface [polypeptide binding]; other site 381754015130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754015131 Walker A motif; other site 381754015132 ATP binding site [chemical binding]; other site 381754015133 Walker B motif; other site 381754015134 arginine finger; other site 381754015135 poly(A) polymerase; Region: pcnB; TIGR01942 381754015136 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 381754015137 active site 381754015138 NTP binding site [chemical binding]; other site 381754015139 metal binding triad [ion binding]; metal-binding site 381754015140 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 381754015141 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 381754015142 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 381754015143 catalytic center binding site [active] 381754015144 ATP binding site [chemical binding]; other site 381754015145 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 381754015146 oligomerization interface [polypeptide binding]; other site 381754015147 active site 381754015148 metal binding site [ion binding]; metal-binding site 381754015149 Pantoate-beta-alanine ligase; Region: PanC; cd00560 381754015150 pantoate--beta-alanine ligase; Region: panC; TIGR00018 381754015151 active site 381754015152 ATP-binding site [chemical binding]; other site 381754015153 pantoate-binding site; other site 381754015154 HXXH motif; other site 381754015155 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 381754015156 tetramerization interface [polypeptide binding]; other site 381754015157 active site 381754015158 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 381754015159 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 381754015160 active site 381754015161 dimer interface [polypeptide binding]; other site 381754015162 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 381754015163 dimer interface [polypeptide binding]; other site 381754015164 active site 381754015165 acetyl-CoA synthetase; Provisional; Region: PRK00174 381754015166 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 381754015167 active site 381754015168 CoA binding site [chemical binding]; other site 381754015169 acyl-activating enzyme (AAE) consensus motif; other site 381754015170 AMP binding site [chemical binding]; other site 381754015171 acetate binding site [chemical binding]; other site 381754015172 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 381754015173 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 381754015174 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 381754015175 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 381754015176 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 381754015177 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 381754015178 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 381754015179 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 381754015180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 381754015181 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 381754015182 BON domain; Region: BON; pfam04972 381754015183 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 381754015184 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 381754015185 RNase E interface [polypeptide binding]; other site 381754015186 trimer interface [polypeptide binding]; other site 381754015187 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 381754015188 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 381754015189 RNase E interface [polypeptide binding]; other site 381754015190 trimer interface [polypeptide binding]; other site 381754015191 active site 381754015192 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 381754015193 putative nucleic acid binding region [nucleotide binding]; other site 381754015194 G-X-X-G motif; other site 381754015195 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 381754015196 RNA binding site [nucleotide binding]; other site 381754015197 domain interface; other site 381754015198 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 381754015199 16S/18S rRNA binding site [nucleotide binding]; other site 381754015200 S13e-L30e interaction site [polypeptide binding]; other site 381754015201 25S rRNA binding site [nucleotide binding]; other site 381754015202 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 381754015203 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 381754015204 RNA binding site [nucleotide binding]; other site 381754015205 active site 381754015206 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 381754015207 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 381754015208 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 381754015209 translation initiation factor IF-2; Region: IF-2; TIGR00487 381754015210 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 381754015211 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 381754015212 G1 box; other site 381754015213 putative GEF interaction site [polypeptide binding]; other site 381754015214 GTP/Mg2+ binding site [chemical binding]; other site 381754015215 Switch I region; other site 381754015216 G2 box; other site 381754015217 G3 box; other site 381754015218 Switch II region; other site 381754015219 G4 box; other site 381754015220 G5 box; other site 381754015221 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 381754015222 Translation-initiation factor 2; Region: IF-2; pfam11987 381754015223 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 381754015224 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 381754015225 NusA N-terminal domain; Region: NusA_N; pfam08529 381754015226 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 381754015227 RNA binding site [nucleotide binding]; other site 381754015228 homodimer interface [polypeptide binding]; other site 381754015229 NusA-like KH domain; Region: KH_5; pfam13184 381754015230 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 381754015231 G-X-X-G motif; other site 381754015232 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 381754015233 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 381754015234 ribosome maturation protein RimP; Reviewed; Region: PRK00092 381754015235 Sm and related proteins; Region: Sm_like; cl00259 381754015236 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 381754015237 putative oligomer interface [polypeptide binding]; other site 381754015238 putative RNA binding site [nucleotide binding]; other site 381754015239 Preprotein translocase SecG subunit; Region: SecG; pfam03840 381754015240 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 381754015241 triosephosphate isomerase; Provisional; Region: PRK14567 381754015242 substrate binding site [chemical binding]; other site 381754015243 dimer interface [polypeptide binding]; other site 381754015244 catalytic triad [active] 381754015245 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 381754015246 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 381754015247 active site 381754015248 substrate binding site [chemical binding]; other site 381754015249 metal binding site [ion binding]; metal-binding site 381754015250 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 381754015251 dihydropteroate synthase; Region: DHPS; TIGR01496 381754015252 substrate binding pocket [chemical binding]; other site 381754015253 dimer interface [polypeptide binding]; other site 381754015254 inhibitor binding site; inhibition site 381754015255 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 381754015256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754015257 Walker A motif; other site 381754015258 ATP binding site [chemical binding]; other site 381754015259 Walker B motif; other site 381754015260 arginine finger; other site 381754015261 Peptidase family M41; Region: Peptidase_M41; pfam01434 381754015262 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 381754015263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754015264 S-adenosylmethionine binding site [chemical binding]; other site 381754015265 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 381754015266 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 381754015267 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 381754015268 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 381754015269 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 381754015270 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 381754015271 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 381754015272 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 381754015273 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 381754015274 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381754015275 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 381754015276 IMP binding site; other site 381754015277 dimer interface [polypeptide binding]; other site 381754015278 interdomain contacts; other site 381754015279 partial ornithine binding site; other site 381754015280 leucine export protein LeuE; Provisional; Region: PRK10958 381754015281 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 381754015282 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 381754015283 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 381754015284 catalytic site [active] 381754015285 subunit interface [polypeptide binding]; other site 381754015286 dihydrodipicolinate reductase; Provisional; Region: PRK00048 381754015287 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 381754015288 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 381754015289 chaperone protein DnaJ; Provisional; Region: PRK10767 381754015290 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 381754015291 HSP70 interaction site [polypeptide binding]; other site 381754015292 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 381754015293 substrate binding site [polypeptide binding]; other site 381754015294 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 381754015295 Zn binding sites [ion binding]; other site 381754015296 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 381754015297 dimer interface [polypeptide binding]; other site 381754015298 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 381754015299 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 381754015300 nucleotide binding site [chemical binding]; other site 381754015301 GrpE; Region: GrpE; pfam01025 381754015302 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 381754015303 dimer interface [polypeptide binding]; other site 381754015304 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 381754015305 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 381754015306 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 381754015307 Walker A/P-loop; other site 381754015308 ATP binding site [chemical binding]; other site 381754015309 Q-loop/lid; other site 381754015310 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 381754015311 ABC transporter signature motif; other site 381754015312 Walker B; other site 381754015313 D-loop; other site 381754015314 H-loop/switch region; other site 381754015315 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 381754015316 metal binding site 2 [ion binding]; metal-binding site 381754015317 putative DNA binding helix; other site 381754015318 metal binding site 1 [ion binding]; metal-binding site 381754015319 dimer interface [polypeptide binding]; other site 381754015320 structural Zn2+ binding site [ion binding]; other site 381754015321 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 381754015322 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 381754015323 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 381754015324 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 381754015325 putative coenzyme Q binding site [chemical binding]; other site 381754015326 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 381754015327 SmpB-tmRNA interface; other site 381754015328 Transcriptional regulators [Transcription]; Region: FadR; COG2186 381754015329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754015330 DNA-binding site [nucleotide binding]; DNA binding site 381754015331 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 381754015332 glycolate transporter; Provisional; Region: PRK09695 381754015333 L-lactate permease; Region: Lactate_perm; cl00701 381754015334 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 381754015335 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 381754015336 phosphate binding site [ion binding]; other site 381754015337 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 381754015338 FAD binding domain; Region: FAD_binding_4; pfam01565 381754015339 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 381754015340 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 381754015341 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 381754015342 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 381754015343 spermidine synthase; Provisional; Region: PRK00811 381754015344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754015345 S-adenosylmethionine binding site [chemical binding]; other site 381754015346 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 381754015347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754015348 active site 381754015349 phosphorylation site [posttranslational modification] 381754015350 intermolecular recognition site; other site 381754015351 dimerization interface [polypeptide binding]; other site 381754015352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754015353 DNA binding site [nucleotide binding] 381754015354 sensor protein QseC; Provisional; Region: PRK10337 381754015355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754015356 dimer interface [polypeptide binding]; other site 381754015357 phosphorylation site [posttranslational modification] 381754015358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754015359 ATP binding site [chemical binding]; other site 381754015360 Mg2+ binding site [ion binding]; other site 381754015361 G-X-G motif; other site 381754015362 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 381754015363 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 381754015364 DNA binding residues [nucleotide binding] 381754015365 dimer interface [polypeptide binding]; other site 381754015366 copper binding site [ion binding]; other site 381754015367 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 381754015368 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 381754015369 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 381754015370 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 381754015371 ATP binding site [chemical binding]; other site 381754015372 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 381754015373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754015374 active site 381754015375 phosphorylation site [posttranslational modification] 381754015376 intermolecular recognition site; other site 381754015377 dimerization interface [polypeptide binding]; other site 381754015378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754015379 Zn2+ binding site [ion binding]; other site 381754015380 Mg2+ binding site [ion binding]; other site 381754015381 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 381754015382 EamA-like transporter family; Region: EamA; pfam00892 381754015383 EamA-like transporter family; Region: EamA; pfam00892 381754015384 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754015385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754015386 putative DNA binding site [nucleotide binding]; other site 381754015387 putative Zn2+ binding site [ion binding]; other site 381754015388 AsnC family; Region: AsnC_trans_reg; pfam01037 381754015389 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 381754015390 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381754015391 dimer interface [polypeptide binding]; other site 381754015392 active site 381754015393 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 381754015394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754015395 NAD(P) binding site [chemical binding]; other site 381754015396 active site 381754015397 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754015398 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754015399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754015400 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 381754015401 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 381754015402 active site 2 [active] 381754015403 active site 1 [active] 381754015404 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 381754015405 homodimer interface [polypeptide binding]; other site 381754015406 chemical substrate binding site [chemical binding]; other site 381754015407 oligomer interface [polypeptide binding]; other site 381754015408 metal binding site [ion binding]; metal-binding site 381754015409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754015410 S-adenosylmethionine binding site [chemical binding]; other site 381754015411 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 381754015412 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 381754015413 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 381754015414 putative active site [active] 381754015415 catalytic site [active] 381754015416 putative metal binding site [ion binding]; other site 381754015417 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 381754015418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754015419 Coenzyme A binding pocket [chemical binding]; other site 381754015420 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 381754015421 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 381754015422 lipoyl attachment site [posttranslational modification]; other site 381754015423 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 381754015424 Predicted amidohydrolase [General function prediction only]; Region: COG0388 381754015425 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 381754015426 active site 381754015427 catalytic triad [active] 381754015428 dimer interface [polypeptide binding]; other site 381754015429 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 381754015430 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 381754015431 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 381754015432 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 381754015433 G1 box; other site 381754015434 putative GEF interaction site [polypeptide binding]; other site 381754015435 GTP/Mg2+ binding site [chemical binding]; other site 381754015436 Switch I region; other site 381754015437 G2 box; other site 381754015438 G3 box; other site 381754015439 Switch II region; other site 381754015440 G4 box; other site 381754015441 G5 box; other site 381754015442 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 381754015443 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 381754015444 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 381754015445 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 381754015446 selenocysteine synthase; Provisional; Region: PRK04311 381754015447 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 381754015448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754015449 catalytic residue [active] 381754015450 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 381754015451 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 381754015452 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 381754015453 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 381754015454 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 381754015455 4Fe-4S binding domain; Region: Fer4; cl02805 381754015456 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 381754015457 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 381754015458 molybdopterin cofactor binding site; other site 381754015459 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 381754015460 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 381754015461 molybdopterin cofactor binding site; other site 381754015462 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 381754015463 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 381754015464 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 381754015465 active site 381754015466 FMN binding site [chemical binding]; other site 381754015467 2,4-decadienoyl-CoA binding site; other site 381754015468 catalytic residue [active] 381754015469 4Fe-4S cluster binding site [ion binding]; other site 381754015470 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 381754015471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754015472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 381754015473 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 381754015474 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 381754015475 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 381754015476 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 381754015477 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 381754015478 Ligand binding site; other site 381754015479 Putative Catalytic site; other site 381754015480 DXD motif; other site 381754015481 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 381754015482 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 381754015483 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 381754015484 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 381754015485 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 381754015486 PhoU domain; Region: PhoU; pfam01895 381754015487 magnesium-transporting ATPase; Provisional; Region: PRK15122 381754015488 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 381754015489 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381754015490 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 381754015491 Soluble P-type ATPase [General function prediction only]; Region: COG4087 381754015492 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 381754015493 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 381754015494 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 381754015495 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 381754015496 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 381754015497 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754015498 CoenzymeA binding site [chemical binding]; other site 381754015499 subunit interaction site [polypeptide binding]; other site 381754015500 PHB binding site; other site 381754015501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754015502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754015503 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 381754015504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754015505 NAD(P) binding site [chemical binding]; other site 381754015506 active site 381754015507 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 381754015508 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 381754015509 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 381754015510 EamA-like transporter family; Region: EamA; pfam00892 381754015511 EamA-like transporter family; Region: EamA; pfam00892 381754015512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 381754015513 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 381754015514 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754015515 Nicotianamine synthase protein; Region: NAS; cl17658 381754015516 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 381754015517 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 381754015518 N-terminal plug; other site 381754015519 ligand-binding site [chemical binding]; other site 381754015520 Predicted membrane protein [Function unknown]; Region: COG3503 381754015521 arginine decarboxylase; Provisional; Region: PRK05354 381754015522 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 381754015523 dimer interface [polypeptide binding]; other site 381754015524 active site 381754015525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381754015526 catalytic residues [active] 381754015527 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 381754015528 translation initiation factor Sui1; Validated; Region: PRK06824 381754015529 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 381754015530 putative rRNA binding site [nucleotide binding]; other site 381754015531 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 381754015532 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 381754015533 nudix motif; other site 381754015534 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 381754015535 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 381754015536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754015537 active site 381754015538 phosphorylation site [posttranslational modification] 381754015539 intermolecular recognition site; other site 381754015540 dimerization interface [polypeptide binding]; other site 381754015541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754015542 metal binding site [ion binding]; metal-binding site 381754015543 active site 381754015544 I-site; other site 381754015545 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381754015546 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754015547 dimer interface [polypeptide binding]; other site 381754015548 putative CheW interface [polypeptide binding]; other site 381754015549 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 381754015550 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 381754015551 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 381754015552 DsbD alpha interface [polypeptide binding]; other site 381754015553 catalytic residues [active] 381754015554 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 381754015555 Dehydroquinase class II; Region: DHquinase_II; pfam01220 381754015556 active site 381754015557 trimer interface [polypeptide binding]; other site 381754015558 dimer interface [polypeptide binding]; other site 381754015559 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 381754015560 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 381754015561 carboxyltransferase (CT) interaction site; other site 381754015562 biotinylation site [posttranslational modification]; other site 381754015563 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 381754015564 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 381754015565 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 381754015566 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 381754015567 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 381754015568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754015569 S-adenosylmethionine binding site [chemical binding]; other site 381754015570 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 381754015571 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 381754015572 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 381754015573 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 381754015574 FMN binding site [chemical binding]; other site 381754015575 active site 381754015576 catalytic residues [active] 381754015577 substrate binding site [chemical binding]; other site 381754015578 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 381754015579 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 381754015580 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 381754015581 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 381754015582 purine monophosphate binding site [chemical binding]; other site 381754015583 dimer interface [polypeptide binding]; other site 381754015584 putative catalytic residues [active] 381754015585 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 381754015586 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 381754015587 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 381754015588 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 381754015589 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 381754015590 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 381754015591 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 381754015592 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 381754015593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754015594 dimer interface [polypeptide binding]; other site 381754015595 phosphorylation site [posttranslational modification] 381754015596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754015597 ATP binding site [chemical binding]; other site 381754015598 Mg2+ binding site [ion binding]; other site 381754015599 G-X-G motif; other site 381754015600 Response regulator receiver domain; Region: Response_reg; pfam00072 381754015601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754015602 active site 381754015603 phosphorylation site [posttranslational modification] 381754015604 intermolecular recognition site; other site 381754015605 dimerization interface [polypeptide binding]; other site 381754015606 Response regulator receiver domain; Region: Response_reg; pfam00072 381754015607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754015608 active site 381754015609 phosphorylation site [posttranslational modification] 381754015610 intermolecular recognition site; other site 381754015611 dimerization interface [polypeptide binding]; other site 381754015612 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 381754015613 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 381754015614 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 381754015615 putative ligand binding site [chemical binding]; other site 381754015616 HEAT repeats; Region: HEAT_2; pfam13646 381754015617 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 381754015618 TM-ABC transporter signature motif; other site 381754015619 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 381754015620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381754015621 TM-ABC transporter signature motif; other site 381754015622 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 381754015623 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 381754015624 Walker A/P-loop; other site 381754015625 ATP binding site [chemical binding]; other site 381754015626 Q-loop/lid; other site 381754015627 ABC transporter signature motif; other site 381754015628 Walker B; other site 381754015629 D-loop; other site 381754015630 H-loop/switch region; other site 381754015631 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 381754015632 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 381754015633 Walker A/P-loop; other site 381754015634 ATP binding site [chemical binding]; other site 381754015635 Q-loop/lid; other site 381754015636 ABC transporter signature motif; other site 381754015637 Walker B; other site 381754015638 D-loop; other site 381754015639 H-loop/switch region; other site 381754015640 putative acetyltransferase; Provisional; Region: PRK03624 381754015641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754015642 Coenzyme A binding pocket [chemical binding]; other site 381754015643 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 381754015644 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 381754015645 alpha-gamma subunit interface [polypeptide binding]; other site 381754015646 beta-gamma subunit interface [polypeptide binding]; other site 381754015647 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 381754015648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754015649 Coenzyme A binding pocket [chemical binding]; other site 381754015650 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 381754015651 gamma-beta subunit interface [polypeptide binding]; other site 381754015652 alpha-beta subunit interface [polypeptide binding]; other site 381754015653 urease subunit alpha; Reviewed; Region: ureC; PRK13207 381754015654 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 381754015655 subunit interactions [polypeptide binding]; other site 381754015656 active site 381754015657 flap region; other site 381754015658 hypothetical protein; Provisional; Region: PRK11019 381754015659 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 381754015660 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 381754015661 tetramer interface [polypeptide binding]; other site 381754015662 active site 381754015663 Mg2+/Mn2+ binding site [ion binding]; other site 381754015664 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 381754015665 putative chaperone; Provisional; Region: PRK11678 381754015666 nucleotide binding site [chemical binding]; other site 381754015667 putative NEF/HSP70 interaction site [polypeptide binding]; other site 381754015668 SBD interface [polypeptide binding]; other site 381754015669 psiF repeat; Region: PsiF_repeat; pfam07769 381754015670 psiF repeat; Region: PsiF_repeat; pfam07769 381754015671 psiF repeat; Region: PsiF_repeat; pfam07769 381754015672 MOSC domain; Region: MOSC; pfam03473 381754015673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 381754015674 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 381754015675 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 381754015676 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 381754015677 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 381754015678 DNA binding residues [nucleotide binding] 381754015679 drug binding residues [chemical binding]; other site 381754015680 dimer interface [polypeptide binding]; other site 381754015681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 381754015682 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 381754015683 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 381754015684 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 381754015685 dinuclear metal binding motif [ion binding]; other site 381754015686 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 381754015687 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 381754015688 Moco binding site; other site 381754015689 metal coordination site [ion binding]; other site 381754015690 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 381754015691 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 381754015692 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 381754015693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754015694 active site 381754015695 phosphorylation site [posttranslational modification] 381754015696 intermolecular recognition site; other site 381754015697 dimerization interface [polypeptide binding]; other site 381754015698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754015699 DNA binding site [nucleotide binding] 381754015700 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 381754015701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754015702 dimerization interface [polypeptide binding]; other site 381754015703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754015704 dimer interface [polypeptide binding]; other site 381754015705 phosphorylation site [posttranslational modification] 381754015706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754015707 ATP binding site [chemical binding]; other site 381754015708 Mg2+ binding site [ion binding]; other site 381754015709 G-X-G motif; other site 381754015710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754015711 putative MFS family transporter protein; Provisional; Region: PRK03633 381754015712 putative substrate translocation pore; other site 381754015713 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 381754015714 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 381754015715 putative di-iron ligands [ion binding]; other site 381754015716 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 381754015717 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 381754015718 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 381754015719 FAD binding pocket [chemical binding]; other site 381754015720 FAD binding motif [chemical binding]; other site 381754015721 phosphate binding motif [ion binding]; other site 381754015722 beta-alpha-beta structure motif; other site 381754015723 NAD binding pocket [chemical binding]; other site 381754015724 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754015725 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 381754015726 catalytic loop [active] 381754015727 iron binding site [ion binding]; other site 381754015728 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 381754015729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754015730 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 381754015731 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 381754015732 dimer interface [polypeptide binding]; other site 381754015733 catalytic residues [active] 381754015734 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 381754015735 UreF; Region: UreF; pfam01730 381754015736 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381754015737 HupE / UreJ protein; Region: HupE_UreJ; cl01011 381754015738 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 381754015739 FecR protein; Region: FecR; pfam04773 381754015740 RNA polymerase sigma factor; Provisional; Region: PRK12529 381754015741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381754015742 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 381754015743 DNA binding residues [nucleotide binding] 381754015744 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754015745 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 381754015746 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 381754015747 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 381754015748 outer membrane porin, OprD family; Region: OprD; pfam03573 381754015749 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 381754015750 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 381754015751 NAD(P) binding site [chemical binding]; other site 381754015752 catalytic residues [active] 381754015753 benzoate transport; Region: 2A0115; TIGR00895 381754015754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754015755 putative substrate translocation pore; other site 381754015756 benzoylformate decarboxylase; Reviewed; Region: PRK07092 381754015757 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 381754015758 PYR/PP interface [polypeptide binding]; other site 381754015759 dimer interface [polypeptide binding]; other site 381754015760 TPP binding site [chemical binding]; other site 381754015761 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754015762 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 381754015763 TPP-binding site [chemical binding]; other site 381754015764 dimer interface [polypeptide binding]; other site 381754015765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754015766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754015767 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 381754015768 substrate binding pocket [chemical binding]; other site 381754015769 dimerization interface [polypeptide binding]; other site 381754015770 benzoate transport; Region: 2A0115; TIGR00895 381754015771 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 381754015772 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 381754015773 iron-sulfur cluster [ion binding]; other site 381754015774 [2Fe-2S] cluster binding site [ion binding]; other site 381754015775 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 381754015776 alpha subunit interface [polypeptide binding]; other site 381754015777 active site 381754015778 substrate binding site [chemical binding]; other site 381754015779 Fe binding site [ion binding]; other site 381754015780 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 381754015781 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 381754015782 FMN-binding pocket [chemical binding]; other site 381754015783 flavin binding motif; other site 381754015784 phosphate binding motif [ion binding]; other site 381754015785 beta-alpha-beta structure motif; other site 381754015786 NAD binding pocket [chemical binding]; other site 381754015787 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754015788 catalytic loop [active] 381754015789 iron binding site [ion binding]; other site 381754015790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754015791 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 381754015792 DNA-binding site [nucleotide binding]; DNA binding site 381754015793 FCD domain; Region: FCD; pfam07729 381754015794 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 381754015795 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 381754015796 putative NAD(P) binding site [chemical binding]; other site 381754015797 homodimer interface [polypeptide binding]; other site 381754015798 homotetramer interface [polypeptide binding]; other site 381754015799 active site 381754015800 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 381754015801 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 381754015802 Walker A/P-loop; other site 381754015803 ATP binding site [chemical binding]; other site 381754015804 Q-loop/lid; other site 381754015805 ABC transporter signature motif; other site 381754015806 Walker B; other site 381754015807 D-loop; other site 381754015808 H-loop/switch region; other site 381754015809 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 381754015810 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 381754015811 Walker A/P-loop; other site 381754015812 ATP binding site [chemical binding]; other site 381754015813 Q-loop/lid; other site 381754015814 ABC transporter signature motif; other site 381754015815 Walker B; other site 381754015816 D-loop; other site 381754015817 H-loop/switch region; other site 381754015818 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 381754015819 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 381754015820 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 381754015821 TM-ABC transporter signature motif; other site 381754015822 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381754015823 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 381754015824 TM-ABC transporter signature motif; other site 381754015825 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 381754015826 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 381754015827 dimerization interface [polypeptide binding]; other site 381754015828 ligand binding site [chemical binding]; other site 381754015829 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754015830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754015831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754015832 dimerization interface [polypeptide binding]; other site 381754015833 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 381754015834 nudix motif; other site 381754015835 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 381754015836 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 381754015837 active site 381754015838 (T/H)XGH motif; other site 381754015839 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 381754015840 catalytic triad [active] 381754015841 metal binding site [ion binding]; metal-binding site 381754015842 conserved cis-peptide bond; other site 381754015843 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 381754015844 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 381754015845 active site 381754015846 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 381754015847 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 381754015848 homodimer interface [polypeptide binding]; other site 381754015849 NAD binding pocket [chemical binding]; other site 381754015850 ATP binding pocket [chemical binding]; other site 381754015851 Mg binding site [ion binding]; other site 381754015852 active-site loop [active] 381754015853 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 381754015854 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 381754015855 active site 381754015856 catalytic triad [active] 381754015857 oxyanion hole [active] 381754015858 Azurin [Energy production and conversion]; Region: COG3241 381754015859 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 381754015860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754015861 Peptidase family M23; Region: Peptidase_M23; pfam01551 381754015862 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 381754015863 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381754015864 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 381754015865 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 381754015866 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 381754015867 Uncharacterized conserved protein [Function unknown]; Region: COG2308 381754015868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 381754015869 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 381754015870 hypothetical protein; Provisional; Region: PRK01254 381754015871 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 381754015872 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 381754015873 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 381754015874 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 381754015875 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754015876 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754015877 metal binding site [ion binding]; metal-binding site 381754015878 active site 381754015879 I-site; other site 381754015880 alanine racemase; Reviewed; Region: alr; PRK00053 381754015881 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 381754015882 active site 381754015883 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381754015884 substrate binding site [chemical binding]; other site 381754015885 catalytic residues [active] 381754015886 dimer interface [polypeptide binding]; other site 381754015887 replicative DNA helicase; Provisional; Region: PRK05748 381754015888 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 381754015889 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 381754015890 Walker A motif; other site 381754015891 ATP binding site [chemical binding]; other site 381754015892 Walker B motif; other site 381754015893 DNA binding loops [nucleotide binding] 381754015894 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 381754015895 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 381754015896 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 381754015897 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 381754015898 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 381754015899 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 381754015900 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 381754015901 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 381754015902 exoribonuclease R; Provisional; Region: PRK11642 381754015903 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 381754015904 RNB domain; Region: RNB; pfam00773 381754015905 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 381754015906 RNA binding site [nucleotide binding]; other site 381754015907 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 381754015908 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 381754015909 GDP-binding site [chemical binding]; other site 381754015910 ACT binding site; other site 381754015911 IMP binding site; other site 381754015912 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 381754015913 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 381754015914 dimer interface [polypeptide binding]; other site 381754015915 motif 1; other site 381754015916 active site 381754015917 motif 2; other site 381754015918 motif 3; other site 381754015919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 381754015920 FtsH protease regulator HflC; Provisional; Region: PRK11029 381754015921 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 381754015922 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 381754015923 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 381754015924 HflK protein; Region: hflK; TIGR01933 381754015925 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 381754015926 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 381754015927 HflX GTPase family; Region: HflX; cd01878 381754015928 G1 box; other site 381754015929 GTP/Mg2+ binding site [chemical binding]; other site 381754015930 Switch I region; other site 381754015931 G2 box; other site 381754015932 G3 box; other site 381754015933 Switch II region; other site 381754015934 G4 box; other site 381754015935 G5 box; other site 381754015936 bacterial Hfq-like; Region: Hfq; cd01716 381754015937 hexamer interface [polypeptide binding]; other site 381754015938 Sm1 motif; other site 381754015939 RNA binding site [nucleotide binding]; other site 381754015940 Sm2 motif; other site 381754015941 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 381754015942 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 381754015943 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 381754015944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754015945 ATP binding site [chemical binding]; other site 381754015946 Mg2+ binding site [ion binding]; other site 381754015947 G-X-G motif; other site 381754015948 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 381754015949 ATP binding site [chemical binding]; other site 381754015950 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 381754015951 AMIN domain; Region: AMIN; pfam11741 381754015952 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 381754015953 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 381754015954 active site 381754015955 metal binding site [ion binding]; metal-binding site 381754015956 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 381754015957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754015958 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 381754015959 putative carbohydrate kinase; Provisional; Region: PRK10565 381754015960 Uncharacterized conserved protein [Function unknown]; Region: COG0062 381754015961 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 381754015962 putative substrate binding site [chemical binding]; other site 381754015963 putative ATP binding site [chemical binding]; other site 381754015964 epoxyqueuosine reductase; Region: TIGR00276 381754015965 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 381754015966 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 381754015967 catalytic site [active] 381754015968 putative active site [active] 381754015969 putative substrate binding site [chemical binding]; other site 381754015970 dimer interface [polypeptide binding]; other site 381754015971 GTPase RsgA; Reviewed; Region: PRK12288 381754015972 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 381754015973 RNA binding site [nucleotide binding]; other site 381754015974 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 381754015975 GTPase/Zn-binding domain interface [polypeptide binding]; other site 381754015976 GTP/Mg2+ binding site [chemical binding]; other site 381754015977 G4 box; other site 381754015978 G5 box; other site 381754015979 G1 box; other site 381754015980 Switch I region; other site 381754015981 G2 box; other site 381754015982 G3 box; other site 381754015983 Switch II region; other site 381754015984 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 381754015985 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 381754015986 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754015987 ligand binding site [chemical binding]; other site 381754015988 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 381754015989 flagellar motor protein MotA; Validated; Region: PRK09110 381754015990 HDOD domain; Region: HDOD; pfam08668 381754015991 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 381754015992 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 381754015993 active site residue [active] 381754015994 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 381754015995 active site residue [active] 381754015996 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 381754015997 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381754015998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754015999 active site 381754016000 phosphorylation site [posttranslational modification] 381754016001 dimerization interface [polypeptide binding]; other site 381754016002 PAS fold; Region: PAS; pfam00989 381754016003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754016004 putative active site [active] 381754016005 heme pocket [chemical binding]; other site 381754016006 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754016007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754016008 metal binding site [ion binding]; metal-binding site 381754016009 active site 381754016010 I-site; other site 381754016011 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754016012 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 381754016013 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 381754016014 phosphoserine phosphatase SerB; Region: serB; TIGR00338 381754016015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754016016 motif II; other site 381754016017 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 381754016018 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 381754016019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 381754016020 Protein of unknown function (DUF330); Region: DUF330; pfam03886 381754016021 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 381754016022 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 381754016023 CAP-like domain; other site 381754016024 active site 381754016025 primary dimer interface [polypeptide binding]; other site 381754016026 Predicted aspartyl protease [General function prediction only]; Region: COG3577 381754016027 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 381754016028 catalytic motif [active] 381754016029 Catalytic residue [active] 381754016030 SdiA-regulated; Region: SdiA-regulated; cd09971 381754016031 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 381754016032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754016033 ATP binding site [chemical binding]; other site 381754016034 Mg2+ binding site [ion binding]; other site 381754016035 G-X-G motif; other site 381754016036 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 381754016037 anchoring element; other site 381754016038 dimer interface [polypeptide binding]; other site 381754016039 ATP binding site [chemical binding]; other site 381754016040 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 381754016041 active site 381754016042 metal binding site [ion binding]; metal-binding site 381754016043 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 381754016044 Predicted esterase [General function prediction only]; Region: COG3150 381754016045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381754016046 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 381754016047 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381754016048 active site 381754016049 metal binding site [ion binding]; metal-binding site 381754016050 hexamer interface [polypeptide binding]; other site 381754016051 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 381754016052 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 381754016053 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 381754016054 dimer interface [polypeptide binding]; other site 381754016055 ADP-ribose binding site [chemical binding]; other site 381754016056 active site 381754016057 nudix motif; other site 381754016058 metal binding site [ion binding]; metal-binding site 381754016059 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 381754016060 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 381754016061 ThiC-associated domain; Region: ThiC-associated; pfam13667 381754016062 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 381754016063 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 381754016064 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 381754016065 haemagglutination activity domain; Region: Haemagg_act; smart00912 381754016066 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 381754016067 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 381754016068 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 381754016069 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 381754016070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754016071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754016072 homodimer interface [polypeptide binding]; other site 381754016073 catalytic residue [active] 381754016074 hypothetical protein; Provisional; Region: PRK07524 381754016075 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 381754016076 PYR/PP interface [polypeptide binding]; other site 381754016077 dimer interface [polypeptide binding]; other site 381754016078 TPP binding site [chemical binding]; other site 381754016079 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754016080 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 381754016081 TPP-binding site [chemical binding]; other site 381754016082 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 381754016083 CoA binding domain; Region: CoA_binding_2; pfam13380 381754016084 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 381754016085 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 381754016086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754016087 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754016088 active site 381754016089 enoyl-CoA hydratase; Provisional; Region: PRK06688 381754016090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 381754016091 substrate binding site [chemical binding]; other site 381754016092 oxyanion hole (OAH) forming residues; other site 381754016093 trimer interface [polypeptide binding]; other site 381754016094 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 381754016095 S-methylmethionine transporter; Provisional; Region: PRK11387 381754016096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381754016097 HAMP domain; Region: HAMP; pfam00672 381754016098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754016099 dimer interface [polypeptide binding]; other site 381754016100 phosphorylation site [posttranslational modification] 381754016101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754016102 ATP binding site [chemical binding]; other site 381754016103 Mg2+ binding site [ion binding]; other site 381754016104 G-X-G motif; other site 381754016105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754016106 Response regulator receiver domain; Region: Response_reg; pfam00072 381754016107 active site 381754016108 phosphorylation site [posttranslational modification] 381754016109 intermolecular recognition site; other site 381754016110 dimerization interface [polypeptide binding]; other site 381754016111 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754016112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754016113 substrate binding pocket [chemical binding]; other site 381754016114 membrane-bound complex binding site; other site 381754016115 hinge residues; other site 381754016116 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 381754016117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754016118 active site 381754016119 phosphorylation site [posttranslational modification] 381754016120 intermolecular recognition site; other site 381754016121 dimerization interface [polypeptide binding]; other site 381754016122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754016123 DNA binding site [nucleotide binding] 381754016124 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 381754016125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754016126 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 381754016127 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381754016128 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 381754016129 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 381754016130 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 381754016131 putative active site [active] 381754016132 putative FMN binding site [chemical binding]; other site 381754016133 putative substrate binding site [chemical binding]; other site 381754016134 putative catalytic residue [active] 381754016135 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 381754016136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754016137 non-specific DNA binding site [nucleotide binding]; other site 381754016138 salt bridge; other site 381754016139 sequence-specific DNA binding site [nucleotide binding]; other site 381754016140 Cupin domain; Region: Cupin_2; pfam07883 381754016141 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 381754016142 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 381754016143 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 381754016144 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754016145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754016146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754016147 dimerization interface [polypeptide binding]; other site 381754016148 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 381754016149 FAD dependent oxidoreductase; Region: DAO; pfam01266 381754016150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381754016151 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 381754016152 active site 381754016153 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 381754016154 catalytic tetrad [active] 381754016155 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754016156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754016157 active site 381754016158 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381754016159 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754016160 active site 381754016161 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 381754016162 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 381754016163 putative ribose interaction site [chemical binding]; other site 381754016164 putative ADP binding site [chemical binding]; other site 381754016165 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 381754016166 active site 381754016167 nucleotide binding site [chemical binding]; other site 381754016168 HIGH motif; other site 381754016169 KMSKS motif; other site 381754016170 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 381754016171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381754016172 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 381754016173 Walker A/P-loop; other site 381754016174 ATP binding site [chemical binding]; other site 381754016175 Q-loop/lid; other site 381754016176 ABC transporter signature motif; other site 381754016177 Walker B; other site 381754016178 D-loop; other site 381754016179 H-loop/switch region; other site 381754016180 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 381754016181 active site 381754016182 substrate binding site [chemical binding]; other site 381754016183 ATP binding site [chemical binding]; other site 381754016184 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 381754016185 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 381754016186 active site 381754016187 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754016188 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 381754016189 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 381754016190 Mig-14; Region: Mig-14; pfam07395 381754016191 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 381754016192 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 381754016193 putative ADP-binding pocket [chemical binding]; other site 381754016194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754016195 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 381754016196 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 381754016197 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 381754016198 active site 381754016199 ATP binding site [chemical binding]; other site 381754016200 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 381754016201 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 381754016202 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 381754016203 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 381754016204 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754016205 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 381754016206 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 381754016207 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 381754016208 putative active site [active] 381754016209 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 381754016210 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 381754016211 putative active site [active] 381754016212 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 381754016213 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 381754016214 homodimer interface [polypeptide binding]; other site 381754016215 substrate-cofactor binding pocket; other site 381754016216 catalytic residue [active] 381754016217 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 381754016218 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 381754016219 metal binding triad; other site 381754016220 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 381754016221 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 381754016222 metal binding triad; other site 381754016223 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 381754016224 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 381754016225 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 381754016226 dimer interface [polypeptide binding]; other site 381754016227 TPP-binding site [chemical binding]; other site 381754016228 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 381754016229 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348 381754016230 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 381754016231 E3 interaction surface; other site 381754016232 lipoyl attachment site [posttranslational modification]; other site 381754016233 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 381754016234 E3 interaction surface; other site 381754016235 lipoyl attachment site [posttranslational modification]; other site 381754016236 e3 binding domain; Region: E3_binding; pfam02817 381754016237 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 381754016238 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 381754016239 GAF domain; Region: GAF; pfam01590 381754016240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754016241 PAS domain; Region: PAS_9; pfam13426 381754016242 putative active site [active] 381754016243 heme pocket [chemical binding]; other site 381754016244 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754016245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754016246 metal binding site [ion binding]; metal-binding site 381754016247 active site 381754016248 I-site; other site 381754016249 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754016250 methionine sulfoxide reductase A; Provisional; Region: PRK00058 381754016251 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 381754016252 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 381754016253 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 381754016254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754016255 active site 381754016256 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 381754016257 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 381754016258 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 381754016259 TrkA-C domain; Region: TrkA_C; pfam02080 381754016260 Transporter associated domain; Region: CorC_HlyC; smart01091 381754016261 hypothetical protein; Provisional; Region: PRK11281 381754016262 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 381754016263 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381754016264 Uncharacterized conserved protein [Function unknown]; Region: COG0397 381754016265 hypothetical protein; Validated; Region: PRK00029 381754016266 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 381754016267 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 381754016268 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 381754016269 homodimer interface [polypeptide binding]; other site 381754016270 substrate-cofactor binding pocket; other site 381754016271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754016272 catalytic residue [active] 381754016273 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754016274 CoenzymeA binding site [chemical binding]; other site 381754016275 subunit interaction site [polypeptide binding]; other site 381754016276 PHB binding site; other site 381754016277 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754016278 Ligand Binding Site [chemical binding]; other site 381754016279 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 381754016280 Ligand Binding Site [chemical binding]; other site 381754016281 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 381754016282 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754016283 P-loop; other site 381754016284 Magnesium ion binding site [ion binding]; other site 381754016285 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754016286 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 381754016287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754016288 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 381754016289 dimerization interface [polypeptide binding]; other site 381754016290 substrate binding pocket [chemical binding]; other site 381754016291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754016292 putative substrate translocation pore; other site 381754016293 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754016294 short chain dehydrogenase; Provisional; Region: PRK06197 381754016295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381754016296 NAD(P) binding site [chemical binding]; other site 381754016297 active site 381754016298 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754016299 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754016300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754016301 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 381754016302 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 381754016303 substrate binding site [chemical binding]; other site 381754016304 active site 381754016305 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 381754016306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754016307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754016308 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 381754016309 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 381754016310 active site 381754016311 dimer interface [polypeptide binding]; other site 381754016312 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 381754016313 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 381754016314 active site 381754016315 FMN binding site [chemical binding]; other site 381754016316 substrate binding site [chemical binding]; other site 381754016317 3Fe-4S cluster binding site [ion binding]; other site 381754016318 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 381754016319 domain interface; other site 381754016320 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 381754016321 AAA ATPase domain; Region: AAA_16; pfam13191 381754016322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 381754016323 Sporulation related domain; Region: SPOR; pfam05036 381754016324 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 381754016325 active site 381754016326 dimer interface [polypeptide binding]; other site 381754016327 metal binding site [ion binding]; metal-binding site 381754016328 shikimate kinase; Reviewed; Region: aroK; PRK00131 381754016329 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 381754016330 ADP binding site [chemical binding]; other site 381754016331 magnesium binding site [ion binding]; other site 381754016332 putative shikimate binding site; other site 381754016333 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 381754016334 AMIN domain; Region: AMIN; pfam11741 381754016335 Secretin and TonB N terminus short domain; Region: STN; smart00965 381754016336 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 381754016337 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381754016338 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 381754016339 Pilus assembly protein, PilP; Region: PilP; pfam04351 381754016340 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 381754016341 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 381754016342 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 381754016343 Competence protein A; Region: Competence_A; pfam11104 381754016344 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 381754016345 nucleotide binding site [chemical binding]; other site 381754016346 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 381754016347 Transglycosylase; Region: Transgly; pfam00912 381754016348 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 381754016349 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 381754016350 Malic enzyme, N-terminal domain; Region: malic; pfam00390 381754016351 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 381754016352 putative NAD(P) binding site [chemical binding]; other site 381754016353 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 381754016354 Peptidase family M48; Region: Peptidase_M48; pfam01435 381754016355 Staphylococcal nuclease homologues; Region: SNc; smart00318 381754016356 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 381754016357 Catalytic site; other site 381754016358 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 381754016359 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 381754016360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754016361 ATP binding site [chemical binding]; other site 381754016362 putative Mg++ binding site [ion binding]; other site 381754016363 helicase superfamily c-terminal domain; Region: HELICc; smart00490 381754016364 nucleotide binding region [chemical binding]; other site 381754016365 ATP-binding site [chemical binding]; other site 381754016366 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 381754016367 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 381754016368 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 381754016369 active site 381754016370 HIGH motif; other site 381754016371 KMSK motif region; other site 381754016372 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 381754016373 tRNA binding surface [nucleotide binding]; other site 381754016374 anticodon binding site; other site 381754016375 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 381754016376 Sporulation related domain; Region: SPOR; pfam05036 381754016377 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 381754016378 active site 381754016379 HslU subunit interaction site [polypeptide binding]; other site 381754016380 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 381754016381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754016382 Walker A motif; other site 381754016383 ATP binding site [chemical binding]; other site 381754016384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754016385 Walker B motif; other site 381754016386 arginine finger; other site 381754016387 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 381754016388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 381754016389 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 381754016390 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 381754016391 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 381754016392 catalytic site [active] 381754016393 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 381754016394 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 381754016395 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 381754016396 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 381754016397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381754016398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754016399 Bacterial transcriptional repressor; Region: TetR; pfam13972 381754016400 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 381754016401 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 381754016402 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 381754016403 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 381754016404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754016405 S-adenosylmethionine binding site [chemical binding]; other site 381754016406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 381754016407 SCP-2 sterol transfer family; Region: SCP2; pfam02036 381754016408 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 381754016409 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 381754016410 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 381754016411 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 381754016412 metal binding site [ion binding]; metal-binding site 381754016413 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 381754016414 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 381754016415 sec-independent translocase; Provisional; Region: tatB; PRK00404 381754016416 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 381754016417 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 381754016418 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 381754016419 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 381754016420 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381754016421 dimer interface [polypeptide binding]; other site 381754016422 putative CheW interface [polypeptide binding]; other site 381754016423 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 381754016424 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 381754016425 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 381754016426 Walker A/P-loop; other site 381754016427 ATP binding site [chemical binding]; other site 381754016428 Q-loop/lid; other site 381754016429 ABC transporter signature motif; other site 381754016430 Walker B; other site 381754016431 D-loop; other site 381754016432 H-loop/switch region; other site 381754016433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754016434 dimer interface [polypeptide binding]; other site 381754016435 conserved gate region; other site 381754016436 putative PBP binding loops; other site 381754016437 ABC-ATPase subunit interface; other site 381754016438 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754016439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754016440 substrate binding pocket [chemical binding]; other site 381754016441 membrane-bound complex binding site; other site 381754016442 hinge residues; other site 381754016443 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 381754016444 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 381754016445 Ligand binding site; other site 381754016446 DXD motif; other site 381754016447 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 381754016448 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 381754016449 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 381754016450 putative active site [active] 381754016451 dimerization interface [polypeptide binding]; other site 381754016452 putative tRNAtyr binding site [nucleotide binding]; other site 381754016453 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 381754016454 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 381754016455 TAP-like protein; Region: Abhydrolase_4; pfam08386 381754016456 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 381754016457 nudix motif; other site 381754016458 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 381754016459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754016460 substrate binding pocket [chemical binding]; other site 381754016461 membrane-bound complex binding site; other site 381754016462 hinge residues; other site 381754016463 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 381754016464 homotrimer interaction site [polypeptide binding]; other site 381754016465 putative active site [active] 381754016466 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 381754016467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381754016468 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 381754016469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754016470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754016471 dimerization interface [polypeptide binding]; other site 381754016472 N-formylglutamate amidohydrolase; Region: FGase; cl01522 381754016473 imidazolonepropionase; Validated; Region: PRK09356 381754016474 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 381754016475 active site 381754016476 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 381754016477 active sites [active] 381754016478 tetramer interface [polypeptide binding]; other site 381754016479 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 381754016480 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 381754016481 Walker A/P-loop; other site 381754016482 ATP binding site [chemical binding]; other site 381754016483 Q-loop/lid; other site 381754016484 ABC transporter signature motif; other site 381754016485 Walker B; other site 381754016486 D-loop; other site 381754016487 H-loop/switch region; other site 381754016488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754016489 dimer interface [polypeptide binding]; other site 381754016490 conserved gate region; other site 381754016491 putative PBP binding loops; other site 381754016492 ABC-ATPase subunit interface; other site 381754016493 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 381754016494 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 381754016495 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 381754016496 active sites [active] 381754016497 tetramer interface [polypeptide binding]; other site 381754016498 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 381754016499 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 381754016500 Na binding site [ion binding]; other site 381754016501 urocanate hydratase; Provisional; Region: PRK05414 381754016502 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 381754016503 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 381754016504 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 381754016505 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 381754016506 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 381754016507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 381754016508 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 381754016509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754016510 DNA-binding site [nucleotide binding]; DNA binding site 381754016511 UTRA domain; Region: UTRA; pfam07702 381754016512 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 381754016513 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 381754016514 active site 381754016515 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 381754016516 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 381754016517 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 381754016518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 381754016519 fructose-1,6-bisphosphatase family protein; Region: PLN02628 381754016520 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 381754016521 AMP binding site [chemical binding]; other site 381754016522 metal binding site [ion binding]; metal-binding site 381754016523 active site 381754016524 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 381754016525 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381754016526 dimer interface [polypeptide binding]; other site 381754016527 active site 381754016528 metal binding site [ion binding]; metal-binding site 381754016529 glutathione binding site [chemical binding]; other site 381754016530 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 381754016531 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 381754016532 active site 381754016533 catalytic triad [active] 381754016534 oxyanion hole [active] 381754016535 Autotransporter beta-domain; Region: Autotransporter; pfam03797 381754016536 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 381754016537 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 381754016538 Predicted membrane protein [Function unknown]; Region: COG5373 381754016539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 381754016540 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 381754016541 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 381754016542 DNA binding residues [nucleotide binding] 381754016543 putative dimer interface [polypeptide binding]; other site 381754016544 putative metal binding residues [ion binding]; other site 381754016545 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 381754016546 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 381754016547 G1 box; other site 381754016548 putative GEF interaction site [polypeptide binding]; other site 381754016549 GTP/Mg2+ binding site [chemical binding]; other site 381754016550 Switch I region; other site 381754016551 G2 box; other site 381754016552 G3 box; other site 381754016553 Switch II region; other site 381754016554 G4 box; other site 381754016555 G5 box; other site 381754016556 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 381754016557 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 381754016558 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 381754016559 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 381754016560 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 381754016561 Ligand Binding Site [chemical binding]; other site 381754016562 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 381754016563 glutamine synthetase; Provisional; Region: glnA; PRK09469 381754016564 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 381754016565 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381754016566 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 381754016567 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381754016568 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 381754016569 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 381754016570 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 381754016571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754016572 putative active site [active] 381754016573 heme pocket [chemical binding]; other site 381754016574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754016575 dimer interface [polypeptide binding]; other site 381754016576 phosphorylation site [posttranslational modification] 381754016577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754016578 ATP binding site [chemical binding]; other site 381754016579 Mg2+ binding site [ion binding]; other site 381754016580 G-X-G motif; other site 381754016581 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 381754016582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754016583 active site 381754016584 phosphorylation site [posttranslational modification] 381754016585 intermolecular recognition site; other site 381754016586 dimerization interface [polypeptide binding]; other site 381754016587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754016588 Walker A motif; other site 381754016589 ATP binding site [chemical binding]; other site 381754016590 Walker B motif; other site 381754016591 arginine finger; other site 381754016592 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754016593 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 381754016594 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 381754016595 SecA binding site; other site 381754016596 Preprotein binding site; other site 381754016597 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 381754016598 GSH binding site [chemical binding]; other site 381754016599 catalytic residues [active] 381754016600 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 381754016601 active site residue [active] 381754016602 phosphoglyceromutase; Provisional; Region: PRK05434 381754016603 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 381754016604 CAAX protease self-immunity; Region: Abi; pfam02517 381754016605 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 381754016606 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 381754016607 Peptidase family M23; Region: Peptidase_M23; pfam01551 381754016608 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 381754016609 C-terminal peptidase (prc); Region: prc; TIGR00225 381754016610 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 381754016611 protein binding site [polypeptide binding]; other site 381754016612 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 381754016613 Catalytic dyad [active] 381754016614 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 381754016615 NodB motif; other site 381754016616 putative active site [active] 381754016617 putative catalytic site [active] 381754016618 Zn binding site [ion binding]; other site 381754016619 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 381754016620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754016621 substrate binding pocket [chemical binding]; other site 381754016622 membrane-bound complex binding site; other site 381754016623 hinge residues; other site 381754016624 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754016625 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754016626 substrate binding pocket [chemical binding]; other site 381754016627 membrane-bound complex binding site; other site 381754016628 hinge residues; other site 381754016629 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754016630 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754016631 substrate binding pocket [chemical binding]; other site 381754016632 membrane-bound complex binding site; other site 381754016633 hinge residues; other site 381754016634 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 381754016635 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 381754016636 substrate binding site [chemical binding]; other site 381754016637 glutamase interaction surface [polypeptide binding]; other site 381754016638 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 381754016639 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 381754016640 catalytic residues [active] 381754016641 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 381754016642 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 381754016643 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 381754016644 putative active site [active] 381754016645 oxyanion strand; other site 381754016646 catalytic triad [active] 381754016647 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 381754016648 putative active site pocket [active] 381754016649 4-fold oligomerization interface [polypeptide binding]; other site 381754016650 metal binding residues [ion binding]; metal-binding site 381754016651 3-fold/trimer interface [polypeptide binding]; other site 381754016652 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 381754016653 Sec63 Brl domain; Region: Sec63; pfam02889 381754016654 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381754016655 FAD dependent oxidoreductase; Region: DAO; pfam01266 381754016656 AsmA family; Region: AsmA; pfam05170 381754016657 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 381754016658 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 381754016659 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 381754016660 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 381754016661 minor groove reading motif; other site 381754016662 helix-hairpin-helix signature motif; other site 381754016663 substrate binding pocket [chemical binding]; other site 381754016664 active site 381754016665 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 381754016666 DNA binding and oxoG recognition site [nucleotide binding] 381754016667 oxidative damage protection protein; Provisional; Region: PRK05408 381754016668 putative oxidoreductase; Provisional; Region: PRK11579 381754016669 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 381754016670 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 381754016671 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 381754016672 classical (c) SDRs; Region: SDR_c; cd05233 381754016673 NAD(P) binding site [chemical binding]; other site 381754016674 active site 381754016675 Uncharacterized conserved protein [Function unknown]; Region: COG2928 381754016676 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 381754016677 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 381754016678 Walker A/P-loop; other site 381754016679 ATP binding site [chemical binding]; other site 381754016680 Q-loop/lid; other site 381754016681 ABC transporter signature motif; other site 381754016682 Walker B; other site 381754016683 D-loop; other site 381754016684 H-loop/switch region; other site 381754016685 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754016686 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754016687 substrate binding pocket [chemical binding]; other site 381754016688 membrane-bound complex binding site; other site 381754016689 hinge residues; other site 381754016690 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381754016691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754016692 dimer interface [polypeptide binding]; other site 381754016693 conserved gate region; other site 381754016694 putative PBP binding loops; other site 381754016695 ABC-ATPase subunit interface; other site 381754016696 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381754016697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754016698 dimer interface [polypeptide binding]; other site 381754016699 conserved gate region; other site 381754016700 putative PBP binding loops; other site 381754016701 ABC-ATPase subunit interface; other site 381754016702 Methyltransferase domain; Region: Methyltransf_32; pfam13679 381754016703 MarR family; Region: MarR_2; cl17246 381754016704 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 381754016705 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 381754016706 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 381754016707 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 381754016708 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754016709 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754016710 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 381754016711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754016712 putative substrate translocation pore; other site 381754016713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754016714 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 381754016715 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 381754016716 NAD binding site [chemical binding]; other site 381754016717 substrate binding site [chemical binding]; other site 381754016718 homodimer interface [polypeptide binding]; other site 381754016719 active site 381754016720 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 381754016721 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 381754016722 NADP binding site [chemical binding]; other site 381754016723 active site 381754016724 putative substrate binding site [chemical binding]; other site 381754016725 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 381754016726 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 381754016727 substrate binding site; other site 381754016728 tetramer interface; other site 381754016729 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 381754016730 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 381754016731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754016732 dimer interface [polypeptide binding]; other site 381754016733 phosphorylation site [posttranslational modification] 381754016734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754016735 ATP binding site [chemical binding]; other site 381754016736 Mg2+ binding site [ion binding]; other site 381754016737 G-X-G motif; other site 381754016738 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754016739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754016740 active site 381754016741 phosphorylation site [posttranslational modification] 381754016742 intermolecular recognition site; other site 381754016743 dimerization interface [polypeptide binding]; other site 381754016744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754016745 Walker A motif; other site 381754016746 ATP binding site [chemical binding]; other site 381754016747 Walker B motif; other site 381754016748 arginine finger; other site 381754016749 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754016750 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 381754016751 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 381754016752 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 381754016753 DctM-like transporters; Region: DctM; pfam06808 381754016754 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 381754016755 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 381754016756 arginine deiminase; Provisional; Region: PRK01388 381754016757 ornithine carbamoyltransferase; Validated; Region: PRK02102 381754016758 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 381754016759 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 381754016760 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 381754016761 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 381754016762 putative substrate binding site [chemical binding]; other site 381754016763 nucleotide binding site [chemical binding]; other site 381754016764 nucleotide binding site [chemical binding]; other site 381754016765 homodimer interface [polypeptide binding]; other site 381754016766 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 381754016767 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 381754016768 active site 381754016769 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 381754016770 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 381754016771 active site 381754016772 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 381754016773 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 381754016774 dimer interface [polypeptide binding]; other site 381754016775 ADP-ribose binding site [chemical binding]; other site 381754016776 active site 381754016777 nudix motif; other site 381754016778 metal binding site [ion binding]; metal-binding site 381754016779 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 381754016780 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 381754016781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754016782 motif II; other site 381754016783 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 381754016784 BON domain; Region: BON; pfam04972 381754016785 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381754016786 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754016787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754016788 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754016789 dimerization interface [polypeptide binding]; other site 381754016790 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 381754016791 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 381754016792 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 381754016793 putative molybdopterin cofactor binding site [chemical binding]; other site 381754016794 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 381754016795 putative molybdopterin cofactor binding site; other site 381754016796 putative transposase OrfB; Reviewed; Region: PHA02517 381754016797 Integrase core domain; Region: rve; pfam00665 381754016798 Integrase core domain; Region: rve_3; pfam13683 381754016799 Global regulator protein family; Region: CsrA; pfam02599 381754016800 chorismate mutase; Provisional; Region: PRK09269 381754016801 Chorismate mutase type II; Region: CM_2; cl00693 381754016802 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 381754016803 active site 381754016804 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 381754016805 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 381754016806 putative active site [active] 381754016807 metal binding site [ion binding]; metal-binding site 381754016808 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 381754016809 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 381754016810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 381754016811 active site 381754016812 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 381754016813 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 381754016814 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381754016815 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754016816 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754016817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754016818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754016819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 381754016820 dimerization interface [polypeptide binding]; other site 381754016821 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 381754016822 dimer interface [polypeptide binding]; other site 381754016823 FMN binding site [chemical binding]; other site 381754016824 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 381754016825 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 381754016826 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 381754016827 active site 381754016828 substrate-binding site [chemical binding]; other site 381754016829 metal-binding site [ion binding] 381754016830 ATP binding site [chemical binding]; other site 381754016831 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 381754016832 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 381754016833 dimerization interface [polypeptide binding]; other site 381754016834 domain crossover interface; other site 381754016835 redox-dependent activation switch; other site 381754016836 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 381754016837 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 381754016838 active site 381754016839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381754016840 RNA binding surface [nucleotide binding]; other site 381754016841 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 381754016842 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 381754016843 RimK-like ATP-grasp domain; Region: RimK; pfam08443 381754016844 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 381754016845 dimer interface [polypeptide binding]; other site 381754016846 catalytic triad [active] 381754016847 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 381754016848 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754016849 dimerization interface [polypeptide binding]; other site 381754016850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754016851 ATP binding site [chemical binding]; other site 381754016852 Mg2+ binding site [ion binding]; other site 381754016853 G-X-G motif; other site 381754016854 osmolarity response regulator; Provisional; Region: ompR; PRK09468 381754016855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754016856 active site 381754016857 phosphorylation site [posttranslational modification] 381754016858 intermolecular recognition site; other site 381754016859 dimerization interface [polypeptide binding]; other site 381754016860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754016861 DNA binding site [nucleotide binding] 381754016862 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 381754016863 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 381754016864 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 381754016865 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 381754016866 RNA binding site [nucleotide binding]; other site 381754016867 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754016868 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 381754016869 CoenzymeA binding site [chemical binding]; other site 381754016870 subunit interaction site [polypeptide binding]; other site 381754016871 PHB binding site; other site 381754016872 glutamate--cysteine ligase; Provisional; Region: PRK02107 381754016873 N-acetylglutamate synthase; Validated; Region: PRK05279 381754016874 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 381754016875 putative feedback inhibition sensing region; other site 381754016876 putative nucleotide binding site [chemical binding]; other site 381754016877 putative substrate binding site [chemical binding]; other site 381754016878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381754016879 Coenzyme A binding pocket [chemical binding]; other site 381754016880 inner membrane protein; Provisional; Region: PRK10995 381754016881 acetylornithine deacetylase; Provisional; Region: PRK05111 381754016882 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 381754016883 metal binding site [ion binding]; metal-binding site 381754016884 putative dimer interface [polypeptide binding]; other site 381754016885 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381754016886 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381754016887 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 381754016888 Uncharacterized conserved protein [Function unknown]; Region: COG3025 381754016889 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 381754016890 putative active site [active] 381754016891 putative metal binding residues [ion binding]; other site 381754016892 signature motif; other site 381754016893 putative triphosphate binding site [ion binding]; other site 381754016894 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 381754016895 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 381754016896 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 381754016897 Walker A motif; other site 381754016898 ATP binding site [chemical binding]; other site 381754016899 Walker B motif; other site 381754016900 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 381754016901 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 381754016902 glycine dehydrogenase; Provisional; Region: PRK12566 381754016903 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 381754016904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381754016905 catalytic residue [active] 381754016906 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 381754016907 tetramer interface [polypeptide binding]; other site 381754016908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754016909 catalytic residue [active] 381754016910 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 381754016911 lipoyl attachment site [posttranslational modification]; other site 381754016912 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 381754016913 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 381754016914 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 381754016915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754016916 dimer interface [polypeptide binding]; other site 381754016917 conserved gate region; other site 381754016918 putative PBP binding loops; other site 381754016919 ABC-ATPase subunit interface; other site 381754016920 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 381754016921 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 381754016922 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 381754016923 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 381754016924 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 381754016925 active site 2 [active] 381754016926 active site 1 [active] 381754016927 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 381754016928 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 381754016929 proline aminopeptidase P II; Provisional; Region: PRK10879 381754016930 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 381754016931 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 381754016932 active site 381754016933 hypothetical protein; Reviewed; Region: PRK02166 381754016934 TIGR02449 family protein; Region: TIGR02449 381754016935 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 381754016936 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 381754016937 Uncharacterized conserved protein [Function unknown]; Region: COG2947 381754016938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381754016939 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 381754016940 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 381754016941 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381754016942 Walker A/P-loop; other site 381754016943 ATP binding site [chemical binding]; other site 381754016944 Q-loop/lid; other site 381754016945 ABC transporter signature motif; other site 381754016946 Walker B; other site 381754016947 D-loop; other site 381754016948 H-loop/switch region; other site 381754016949 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381754016950 Walker A/P-loop; other site 381754016951 ATP binding site [chemical binding]; other site 381754016952 Q-loop/lid; other site 381754016953 ABC transporter signature motif; other site 381754016954 Walker B; other site 381754016955 D-loop; other site 381754016956 H-loop/switch region; other site 381754016957 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381754016958 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 381754016959 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 381754016960 HlyD family secretion protein; Region: HlyD_3; pfam13437 381754016961 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 381754016962 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 381754016963 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 381754016964 NAD(P) binding site [chemical binding]; other site 381754016965 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 381754016966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754016967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754016968 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 381754016969 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754016970 catalytic loop [active] 381754016971 iron binding site [ion binding]; other site 381754016972 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 381754016973 FAD binding pocket [chemical binding]; other site 381754016974 FAD binding motif [chemical binding]; other site 381754016975 phosphate binding motif [ion binding]; other site 381754016976 beta-alpha-beta structure motif; other site 381754016977 NAD binding pocket [chemical binding]; other site 381754016978 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 381754016979 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 381754016980 transcription termination factor Rho; Provisional; Region: rho; PRK09376 381754016981 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 381754016982 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 381754016983 RNA binding site [nucleotide binding]; other site 381754016984 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 381754016985 multimer interface [polypeptide binding]; other site 381754016986 Walker A motif; other site 381754016987 ATP binding site [chemical binding]; other site 381754016988 Walker B motif; other site 381754016989 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 381754016990 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 381754016991 catalytic residues [active] 381754016992 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 381754016993 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 381754016994 polyphosphate kinase; Provisional; Region: PRK05443 381754016995 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 381754016996 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 381754016997 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 381754016998 putative domain interface [polypeptide binding]; other site 381754016999 putative active site [active] 381754017000 catalytic site [active] 381754017001 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 381754017002 putative domain interface [polypeptide binding]; other site 381754017003 putative active site [active] 381754017004 catalytic site [active] 381754017005 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 381754017006 dimer interface [polypeptide binding]; other site 381754017007 active site 381754017008 aspartate-rich active site metal binding site; other site 381754017009 allosteric magnesium binding site [ion binding]; other site 381754017010 Schiff base residues; other site 381754017011 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 381754017012 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 381754017013 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 381754017014 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 381754017015 conserved cys residue [active] 381754017016 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 381754017017 CoenzymeA binding site [chemical binding]; other site 381754017018 subunit interaction site [polypeptide binding]; other site 381754017019 PHB binding site; other site 381754017020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 381754017021 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 381754017022 Cytochrome c; Region: Cytochrom_C; pfam00034 381754017023 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 381754017024 LysE type translocator; Region: LysE; cl00565 381754017025 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 381754017026 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 381754017027 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381754017028 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 381754017029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754017030 Walker A/P-loop; other site 381754017031 ATP binding site [chemical binding]; other site 381754017032 Q-loop/lid; other site 381754017033 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754017034 ABC transporter; Region: ABC_tran_2; pfam12848 381754017035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381754017036 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 381754017037 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 381754017038 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 381754017039 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 381754017040 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 381754017041 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 381754017042 HemY protein N-terminus; Region: HemY_N; pfam07219 381754017043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381754017044 binding surface 381754017045 TPR motif; other site 381754017046 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 381754017047 uroporphyrinogen-III synthase; Validated; Region: PRK05752 381754017048 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 381754017049 active site 381754017050 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 381754017051 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 381754017052 domain interfaces; other site 381754017053 active site 381754017054 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 381754017055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754017056 active site 381754017057 phosphorylation site [posttranslational modification] 381754017058 intermolecular recognition site; other site 381754017059 dimerization interface [polypeptide binding]; other site 381754017060 LytTr DNA-binding domain; Region: LytTR; pfam04397 381754017061 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 381754017062 Histidine kinase; Region: His_kinase; pfam06580 381754017063 argininosuccinate lyase; Provisional; Region: PRK00855 381754017064 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 381754017065 active sites [active] 381754017066 tetramer interface [polypeptide binding]; other site 381754017067 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 381754017068 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 381754017069 Cl binding site [ion binding]; other site 381754017070 oligomer interface [polypeptide binding]; other site 381754017071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381754017072 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754017073 substrate binding pocket [chemical binding]; other site 381754017074 membrane-bound complex binding site; other site 381754017075 hinge residues; other site 381754017076 Phosphate-starvation-inducible E; Region: PsiE; cl01264 381754017077 adenylate cyclase; Provisional; Region: cyaA; PRK09450 381754017078 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 381754017079 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 381754017080 Uncharacterized conserved protein [Function unknown]; Region: COG4278 381754017081 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 381754017082 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 381754017083 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 381754017084 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 381754017085 putative iron binding site [ion binding]; other site 381754017086 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 381754017087 diaminopimelate decarboxylase; Region: lysA; TIGR01048 381754017088 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 381754017089 active site 381754017090 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381754017091 substrate binding site [chemical binding]; other site 381754017092 catalytic residues [active] 381754017093 dimer interface [polypeptide binding]; other site 381754017094 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 381754017095 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 381754017096 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 381754017097 Protein of unknown function, DUF484; Region: DUF484; pfam04340 381754017098 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 381754017099 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381754017100 active site 381754017101 DNA binding site [nucleotide binding] 381754017102 Int/Topo IB signature motif; other site 381754017103 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 381754017104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381754017105 motif II; other site 381754017106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754017107 putative substrate translocation pore; other site 381754017108 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754017109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754017110 DNA-binding site [nucleotide binding]; DNA binding site 381754017111 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754017112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754017113 homodimer interface [polypeptide binding]; other site 381754017114 catalytic residue [active] 381754017115 Uncharacterized conserved protein [Function unknown]; Region: COG0432 381754017116 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 381754017117 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 381754017118 Nitrogen regulatory protein P-II; Region: P-II; smart00938 381754017119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 381754017120 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 381754017121 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 381754017122 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 381754017123 putative transposase OrfB; Reviewed; Region: PHA02517 381754017124 HTH-like domain; Region: HTH_21; pfam13276 381754017125 Integrase core domain; Region: rve; pfam00665 381754017126 Integrase core domain; Region: rve_3; pfam13683 381754017127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381754017128 Transposase; Region: HTH_Tnp_1; pfam01527 381754017129 putative transposase OrfB; Reviewed; Region: PHA02517 381754017130 HTH-like domain; Region: HTH_21; pfam13276 381754017131 Integrase core domain; Region: rve; pfam00665 381754017132 Integrase core domain; Region: rve_3; pfam13683 381754017133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381754017134 Transposase; Region: HTH_Tnp_1; pfam01527 381754017135 Transposase, Mutator family; Region: Transposase_mut; pfam00872 381754017136 MULE transposase domain; Region: MULE; pfam10551 381754017137 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 381754017138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754017139 ATP binding site [chemical binding]; other site 381754017140 putative Mg++ binding site [ion binding]; other site 381754017141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754017142 nucleotide binding region [chemical binding]; other site 381754017143 ATP-binding site [chemical binding]; other site 381754017144 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 381754017145 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381754017146 ligand binding site [chemical binding]; other site 381754017147 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 381754017148 Protein of unknown function DUF91; Region: DUF91; cl00709 381754017149 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 381754017150 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 381754017151 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 381754017152 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 381754017153 HsdM N-terminal domain; Region: HsdM_N; pfam12161 381754017154 Methyltransferase domain; Region: Methyltransf_26; pfam13659 381754017155 HNH endonuclease; Region: HNH_2; pfam13391 381754017156 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 381754017157 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 381754017158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754017159 ATP binding site [chemical binding]; other site 381754017160 putative Mg++ binding site [ion binding]; other site 381754017161 Peptidase M15; Region: Peptidase_M15_3; cl01194 381754017162 Predicted transcriptional regulator [Transcription]; Region: COG2378 381754017163 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 381754017164 WYL domain; Region: WYL; pfam13280 381754017165 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381754017166 G1 box; other site 381754017167 GTP/Mg2+ binding site [chemical binding]; other site 381754017168 G2 box; other site 381754017169 Switch I region; other site 381754017170 G3 box; other site 381754017171 Switch II region; other site 381754017172 G4 box; other site 381754017173 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381754017174 G1 box; other site 381754017175 GTP/Mg2+ binding site [chemical binding]; other site 381754017176 G2 box; other site 381754017177 Switch I region; other site 381754017178 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381754017179 G3 box; other site 381754017180 Switch II region; other site 381754017181 G4 box; other site 381754017182 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381754017183 Dynamin family; Region: Dynamin_N; pfam00350 381754017184 G1 box; other site 381754017185 GTP/Mg2+ binding site [chemical binding]; other site 381754017186 G2 box; other site 381754017187 Switch I region; other site 381754017188 G3 box; other site 381754017189 Switch II region; other site 381754017190 G4 box; other site 381754017191 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 381754017192 active site 381754017193 catalytic residues [active] 381754017194 DNA binding site [nucleotide binding] 381754017195 Int/Topo IB signature motif; other site 381754017196 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 381754017197 active site 381754017198 catalytic residues [active] 381754017199 DNA binding site [nucleotide binding] 381754017200 Int/Topo IB signature motif; other site 381754017201 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 381754017202 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 381754017203 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 381754017204 BCCT family transporter; Region: BCCT; cl00569 381754017205 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 381754017206 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 381754017207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754017208 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 381754017209 dimerization interface [polypeptide binding]; other site 381754017210 substrate binding pocket [chemical binding]; other site 381754017211 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 381754017212 multidrug efflux protein NorA; Provisional; Region: PRK00187 381754017213 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 381754017214 cation binding site [ion binding]; other site 381754017215 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754017216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754017217 metal binding site [ion binding]; metal-binding site 381754017218 active site 381754017219 I-site; other site 381754017220 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754017221 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 381754017222 Family description; Region: UvrD_C_2; pfam13538 381754017223 pyruvate dehydrogenase; Provisional; Region: PRK09124 381754017224 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 381754017225 PYR/PP interface [polypeptide binding]; other site 381754017226 dimer interface [polypeptide binding]; other site 381754017227 tetramer interface [polypeptide binding]; other site 381754017228 TPP binding site [chemical binding]; other site 381754017229 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 381754017230 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 381754017231 TPP-binding site [chemical binding]; other site 381754017232 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754017233 active site 381754017234 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 381754017235 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 381754017236 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 381754017237 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 381754017238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754017239 non-specific DNA binding site [nucleotide binding]; other site 381754017240 salt bridge; other site 381754017241 sequence-specific DNA binding site [nucleotide binding]; other site 381754017242 Cupin domain; Region: Cupin_2; pfam07883 381754017243 alanine racemase; Reviewed; Region: dadX; PRK03646 381754017244 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 381754017245 active site 381754017246 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381754017247 substrate binding site [chemical binding]; other site 381754017248 catalytic residues [active] 381754017249 dimer interface [polypeptide binding]; other site 381754017250 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 381754017251 homotrimer interaction site [polypeptide binding]; other site 381754017252 putative active site [active] 381754017253 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 381754017254 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381754017255 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 381754017256 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 381754017257 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 381754017258 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 381754017259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381754017260 putative DNA binding site [nucleotide binding]; other site 381754017261 putative Zn2+ binding site [ion binding]; other site 381754017262 AsnC family; Region: AsnC_trans_reg; pfam01037 381754017263 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754017264 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381754017265 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 381754017266 PLD-like domain; Region: PLDc_2; pfam13091 381754017267 putative active site [active] 381754017268 catalytic site [active] 381754017269 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 381754017270 PLD-like domain; Region: PLDc_2; pfam13091 381754017271 putative active site [active] 381754017272 catalytic site [active] 381754017273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754017274 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381754017275 putative substrate translocation pore; other site 381754017276 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 381754017277 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 381754017278 NAD(P) binding site [chemical binding]; other site 381754017279 catalytic residues [active] 381754017280 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 381754017281 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754017282 inhibitor-cofactor binding pocket; inhibition site 381754017283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754017284 catalytic residue [active] 381754017285 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 381754017286 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 381754017287 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 381754017288 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381754017289 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 381754017290 peptide binding site [polypeptide binding]; other site 381754017291 hypothetical protein; Reviewed; Region: PRK00024 381754017292 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 381754017293 MPN+ (JAMM) motif; other site 381754017294 Zinc-binding site [ion binding]; other site 381754017295 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 381754017296 Flavoprotein; Region: Flavoprotein; pfam02441 381754017297 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 381754017298 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 381754017299 trimer interface [polypeptide binding]; other site 381754017300 active site 381754017301 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 381754017302 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 381754017303 active site 381754017304 substrate binding site [chemical binding]; other site 381754017305 metal binding site [ion binding]; metal-binding site 381754017306 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 381754017307 feedback inhibition sensing region; other site 381754017308 homohexameric interface [polypeptide binding]; other site 381754017309 nucleotide binding site [chemical binding]; other site 381754017310 N-acetyl-L-glutamate binding site [chemical binding]; other site 381754017311 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 381754017312 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 381754017313 SurA N-terminal domain; Region: SurA_N; pfam09312 381754017314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754017315 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 381754017316 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 381754017317 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 381754017318 dimer interface [polypeptide binding]; other site 381754017319 active site 381754017320 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381754017321 substrate binding site [chemical binding]; other site 381754017322 catalytic residue [active] 381754017323 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 381754017324 FAD binding domain; Region: FAD_binding_4; pfam01565 381754017325 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 381754017326 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 381754017327 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 381754017328 active site 381754017329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381754017330 active site 381754017331 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 381754017332 putative active site [active] 381754017333 putative catalytic site [active] 381754017334 putative DNA binding site [nucleotide binding]; other site 381754017335 putative phosphate binding site [ion binding]; other site 381754017336 metal binding site A [ion binding]; metal-binding site 381754017337 putative AP binding site [nucleotide binding]; other site 381754017338 putative metal binding site B [ion binding]; other site 381754017339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 381754017340 ribonuclease PH; Reviewed; Region: rph; PRK00173 381754017341 Ribonuclease PH; Region: RNase_PH_bact; cd11362 381754017342 hexamer interface [polypeptide binding]; other site 381754017343 active site 381754017344 hypothetical protein; Provisional; Region: PRK11820 381754017345 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 381754017346 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 381754017347 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 381754017348 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 381754017349 catalytic site [active] 381754017350 G-X2-G-X-G-K; other site 381754017351 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 381754017352 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 381754017353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381754017354 Zn2+ binding site [ion binding]; other site 381754017355 Mg2+ binding site [ion binding]; other site 381754017356 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 381754017357 synthetase active site [active] 381754017358 NTP binding site [chemical binding]; other site 381754017359 metal binding site [ion binding]; metal-binding site 381754017360 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 381754017361 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 381754017362 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 381754017363 homotrimer interaction site [polypeptide binding]; other site 381754017364 putative active site [active] 381754017365 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 381754017366 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 381754017367 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 381754017368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754017369 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 381754017370 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 381754017371 putative NAD(P) binding site [chemical binding]; other site 381754017372 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 381754017373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754017374 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 381754017375 dimerization interface [polypeptide binding]; other site 381754017376 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 381754017377 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 381754017378 ssDNA binding site; other site 381754017379 generic binding surface II; other site 381754017380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381754017381 ATP binding site [chemical binding]; other site 381754017382 putative Mg++ binding site [ion binding]; other site 381754017383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381754017384 nucleotide binding region [chemical binding]; other site 381754017385 ATP-binding site [chemical binding]; other site 381754017386 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 381754017387 putative deacylase active site [active] 381754017388 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 381754017389 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 381754017390 IHF dimer interface [polypeptide binding]; other site 381754017391 IHF - DNA interface [nucleotide binding]; other site 381754017392 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 381754017393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381754017394 hypothetical protein; Provisional; Region: PRK07236 381754017395 Rubredoxin [Energy production and conversion]; Region: COG1773 381754017396 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 381754017397 iron binding site [ion binding]; other site 381754017398 Rubredoxin [Energy production and conversion]; Region: COG1773 381754017399 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 381754017400 iron binding site [ion binding]; other site 381754017401 Domain of unknown function (DUF336); Region: DUF336; cl01249 381754017402 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 381754017403 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 381754017404 Cysteine-rich domain; Region: CCG; pfam02754 381754017405 Cysteine-rich domain; Region: CCG; pfam02754 381754017406 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 381754017407 FAD binding domain; Region: FAD_binding_4; pfam01565 381754017408 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 381754017409 FAD binding domain; Region: FAD_binding_4; pfam01565 381754017410 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 381754017411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754017412 DNA-binding site [nucleotide binding]; DNA binding site 381754017413 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 381754017414 Chorismate lyase; Region: Chor_lyase; pfam04345 381754017415 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 381754017416 UbiA prenyltransferase family; Region: UbiA; pfam01040 381754017417 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 381754017418 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 381754017419 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 381754017420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754017421 active site 381754017422 phosphorylation site [posttranslational modification] 381754017423 intermolecular recognition site; other site 381754017424 dimerization interface [polypeptide binding]; other site 381754017425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381754017426 DNA binding site [nucleotide binding] 381754017427 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 381754017428 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754017429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754017430 putative active site [active] 381754017431 heme pocket [chemical binding]; other site 381754017432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754017433 dimer interface [polypeptide binding]; other site 381754017434 phosphorylation site [posttranslational modification] 381754017435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754017436 ATP binding site [chemical binding]; other site 381754017437 Mg2+ binding site [ion binding]; other site 381754017438 G-X-G motif; other site 381754017439 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 381754017440 Domain of unknown function DUF21; Region: DUF21; pfam01595 381754017441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 381754017442 Transporter associated domain; Region: CorC_HlyC; smart01091 381754017443 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 381754017444 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 381754017445 Peptidase family M23; Region: Peptidase_M23; pfam01551 381754017446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754017447 Response regulator receiver domain; Region: Response_reg; pfam00072 381754017448 active site 381754017449 phosphorylation site [posttranslational modification] 381754017450 intermolecular recognition site; other site 381754017451 dimerization interface [polypeptide binding]; other site 381754017452 transcriptional regulator PhoU; Provisional; Region: PRK11115 381754017453 PhoU domain; Region: PhoU; pfam01895 381754017454 PhoU domain; Region: PhoU; pfam01895 381754017455 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 381754017456 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 381754017457 Walker A/P-loop; other site 381754017458 ATP binding site [chemical binding]; other site 381754017459 Q-loop/lid; other site 381754017460 ABC transporter signature motif; other site 381754017461 Walker B; other site 381754017462 D-loop; other site 381754017463 H-loop/switch region; other site 381754017464 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 381754017465 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 381754017466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754017467 dimer interface [polypeptide binding]; other site 381754017468 conserved gate region; other site 381754017469 putative PBP binding loops; other site 381754017470 ABC-ATPase subunit interface; other site 381754017471 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 381754017472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754017473 ABC-ATPase subunit interface; other site 381754017474 PBP superfamily domain; Region: PBP_like_2; cl17296 381754017475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754017476 metabolite-proton symporter; Region: 2A0106; TIGR00883 381754017477 putative substrate translocation pore; other site 381754017478 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 381754017479 choline dehydrogenase; Validated; Region: PRK02106 381754017480 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 381754017481 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 381754017482 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 381754017483 tetrameric interface [polypeptide binding]; other site 381754017484 NAD binding site [chemical binding]; other site 381754017485 catalytic residues [active] 381754017486 transcriptional regulator BetI; Validated; Region: PRK00767 381754017487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381754017488 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 381754017489 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 381754017490 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 381754017491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381754017492 Walker A/P-loop; other site 381754017493 ATP binding site [chemical binding]; other site 381754017494 Q-loop/lid; other site 381754017495 ABC transporter signature motif; other site 381754017496 Walker B; other site 381754017497 D-loop; other site 381754017498 H-loop/switch region; other site 381754017499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754017500 dimer interface [polypeptide binding]; other site 381754017501 conserved gate region; other site 381754017502 putative PBP binding loops; other site 381754017503 ABC-ATPase subunit interface; other site 381754017504 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 381754017505 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 381754017506 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 381754017507 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 381754017508 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 381754017509 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 381754017510 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 381754017511 conserved cys residue [active] 381754017512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754017513 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 381754017514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754017515 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 381754017516 putative dimerization interface [polypeptide binding]; other site 381754017517 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 381754017518 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 381754017519 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 381754017520 active site 381754017521 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 381754017522 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381754017523 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 381754017524 Uncharacterized conserved protein [Function unknown]; Region: COG3246 381754017525 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 381754017526 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 381754017527 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 381754017528 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 381754017529 conserved cys residue [active] 381754017530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 381754017531 acetylornithine deacetylase; Provisional; Region: PRK07522 381754017532 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 381754017533 metal binding site [ion binding]; metal-binding site 381754017534 putative dimer interface [polypeptide binding]; other site 381754017535 Uncharacterized conserved protein [Function unknown]; Region: COG3342 381754017536 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 381754017537 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 381754017538 homotrimer interaction site [polypeptide binding]; other site 381754017539 putative active site [active] 381754017540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381754017541 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 381754017542 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 381754017543 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 381754017544 putative active site [active] 381754017545 catalytic site [active] 381754017546 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 381754017547 putative active site [active] 381754017548 catalytic site [active] 381754017549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 381754017550 SnoaL-like domain; Region: SnoaL_2; pfam12680 381754017551 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 381754017552 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 381754017553 active site 381754017554 V4R domain; Region: V4R; cl15268 381754017555 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 381754017556 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 381754017557 putative active site [active] 381754017558 putative FMN binding site [chemical binding]; other site 381754017559 putative substrate binding site [chemical binding]; other site 381754017560 putative catalytic residue [active] 381754017561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381754017562 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 381754017563 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 381754017564 Cysteine-rich domain; Region: CCG; pfam02754 381754017565 Cysteine-rich domain; Region: CCG; pfam02754 381754017566 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 381754017567 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 381754017568 Ligand Binding Site [chemical binding]; other site 381754017569 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 381754017570 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 381754017571 Ligand Binding Site [chemical binding]; other site 381754017572 Electron transfer flavoprotein domain; Region: ETF; pfam01012 381754017573 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 381754017574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381754017575 non-specific DNA binding site [nucleotide binding]; other site 381754017576 salt bridge; other site 381754017577 sequence-specific DNA binding site [nucleotide binding]; other site 381754017578 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 381754017579 Cell division protein ZapA; Region: ZapA; pfam05164 381754017580 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 381754017581 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 381754017582 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 381754017583 [2Fe-2S] cluster binding site [ion binding]; other site 381754017584 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 381754017585 putative alpha subunit interface [polypeptide binding]; other site 381754017586 putative active site [active] 381754017587 putative substrate binding site [chemical binding]; other site 381754017588 Fe binding site [ion binding]; other site 381754017589 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 381754017590 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 381754017591 FAD binding pocket [chemical binding]; other site 381754017592 FAD binding motif [chemical binding]; other site 381754017593 phosphate binding motif [ion binding]; other site 381754017594 beta-alpha-beta structure motif; other site 381754017595 NAD binding pocket [chemical binding]; other site 381754017596 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381754017597 catalytic loop [active] 381754017598 iron binding site [ion binding]; other site 381754017599 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 381754017600 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 381754017601 tetramer interface [polypeptide binding]; other site 381754017602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754017603 catalytic residue [active] 381754017604 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 381754017605 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 381754017606 dimer interface [polypeptide binding]; other site 381754017607 active site 381754017608 glycine-pyridoxal phosphate binding site [chemical binding]; other site 381754017609 folate binding site [chemical binding]; other site 381754017610 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 381754017611 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 381754017612 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 381754017613 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 381754017614 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 381754017615 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 381754017616 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 381754017617 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 381754017618 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 381754017619 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 381754017620 putative active site [active] 381754017621 putative substrate binding site [chemical binding]; other site 381754017622 putative cosubstrate binding site; other site 381754017623 catalytic site [active] 381754017624 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 381754017625 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 381754017626 NAD binding site [chemical binding]; other site 381754017627 catalytic Zn binding site [ion binding]; other site 381754017628 structural Zn binding site [ion binding]; other site 381754017629 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 381754017630 active site 381754017631 phosphate binding residues; other site 381754017632 catalytic residues [active] 381754017633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3495 381754017634 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 381754017635 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 381754017636 ATP-grasp domain; Region: ATP-grasp; pfam02222 381754017637 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 381754017638 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 381754017639 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 381754017640 NAD binding site [chemical binding]; other site 381754017641 substrate binding site [chemical binding]; other site 381754017642 catalytic Zn binding site [ion binding]; other site 381754017643 tetramer interface [polypeptide binding]; other site 381754017644 structural Zn binding site [ion binding]; other site 381754017645 cell density-dependent motility repressor; Provisional; Region: PRK10082 381754017646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754017647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 381754017648 dimerization interface [polypeptide binding]; other site 381754017649 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 381754017650 Aspartase; Region: Aspartase; cd01357 381754017651 active sites [active] 381754017652 tetramer interface [polypeptide binding]; other site 381754017653 Predicted transporter component [General function prediction only]; Region: COG2391 381754017654 Sulphur transport; Region: Sulf_transp; pfam04143 381754017655 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 381754017656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754017657 DNA-binding site [nucleotide binding]; DNA binding site 381754017658 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381754017659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754017660 homodimer interface [polypeptide binding]; other site 381754017661 catalytic residue [active] 381754017662 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 381754017663 Coenzyme A binding pocket [chemical binding]; other site 381754017664 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 381754017665 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 381754017666 tryptophan permease; Provisional; Region: PRK10483 381754017667 aromatic amino acid transport protein; Region: araaP; TIGR00837 381754017668 pyruvate carboxylase subunit B; Validated; Region: PRK09282 381754017669 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 381754017670 active site 381754017671 catalytic residues [active] 381754017672 metal binding site [ion binding]; metal-binding site 381754017673 homodimer binding site [polypeptide binding]; other site 381754017674 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 381754017675 carboxyltransferase (CT) interaction site; other site 381754017676 biotinylation site [posttranslational modification]; other site 381754017677 pyruvate carboxylase subunit A; Validated; Region: PRK07178 381754017678 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 381754017679 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 381754017680 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 381754017681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 381754017682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 381754017683 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 381754017684 putative dimerization interface [polypeptide binding]; other site 381754017685 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 381754017686 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 381754017687 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 381754017688 putative active site [active] 381754017689 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 381754017690 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 381754017691 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 381754017692 putative protease; Provisional; Region: PRK15452 381754017693 Peptidase family U32; Region: Peptidase_U32; pfam01136 381754017694 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 381754017695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754017696 PAS domain; Region: PAS_9; pfam13426 381754017697 putative active site [active] 381754017698 heme pocket [chemical binding]; other site 381754017699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754017700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754017701 metal binding site [ion binding]; metal-binding site 381754017702 active site 381754017703 I-site; other site 381754017704 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381754017705 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 381754017706 Part of AAA domain; Region: AAA_19; pfam13245 381754017707 Family description; Region: UvrD_C_2; pfam13538 381754017708 Predicted membrane protein [Function unknown]; Region: COG2510 381754017709 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 381754017710 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 381754017711 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 381754017712 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 381754017713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754017714 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 381754017715 putative ADP-binding pocket [chemical binding]; other site 381754017716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754017717 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 381754017718 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 381754017719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754017720 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 381754017721 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 381754017722 Walker A/P-loop; other site 381754017723 ATP binding site [chemical binding]; other site 381754017724 Q-loop/lid; other site 381754017725 ABC transporter signature motif; other site 381754017726 Walker B; other site 381754017727 D-loop; other site 381754017728 H-loop/switch region; other site 381754017729 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 381754017730 putative carbohydrate binding site [chemical binding]; other site 381754017731 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 381754017732 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 381754017733 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 381754017734 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 381754017735 Substrate binding site; other site 381754017736 Cupin domain; Region: Cupin_2; cl17218 381754017737 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 381754017738 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 381754017739 NADP-binding site; other site 381754017740 homotetramer interface [polypeptide binding]; other site 381754017741 substrate binding site [chemical binding]; other site 381754017742 homodimer interface [polypeptide binding]; other site 381754017743 active site 381754017744 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 381754017745 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 381754017746 NADP-binding site; other site 381754017747 homotetramer interface [polypeptide binding]; other site 381754017748 substrate binding site [chemical binding]; other site 381754017749 homodimer interface [polypeptide binding]; other site 381754017750 active site 381754017751 Divergent PAP2 family; Region: DUF212; cl00855 381754017752 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 381754017753 GtrA-like protein; Region: GtrA; pfam04138 381754017754 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 381754017755 FAD binding domain; Region: FAD_binding_4; pfam01565 381754017756 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 381754017757 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 381754017758 classical (c) SDRs; Region: SDR_c; cd05233 381754017759 NAD(P) binding site [chemical binding]; other site 381754017760 active site 381754017761 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 381754017762 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381754017763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754017764 S-adenosylmethionine binding site [chemical binding]; other site 381754017765 Acyltransferase family; Region: Acyl_transf_3; pfam01757 381754017766 Methyltransferase domain; Region: Methyltransf_23; pfam13489 381754017767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754017768 S-adenosylmethionine binding site [chemical binding]; other site 381754017769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754017770 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 381754017771 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381754017772 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 381754017773 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 381754017774 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 381754017775 conserverd hypothetical protein; Region: TIGR02448 381754017776 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 381754017777 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 381754017778 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 381754017779 Uncharacterized conserved protein [Function unknown]; Region: COG3791 381754017780 Predicted permeases [General function prediction only]; Region: COG0679 381754017781 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 381754017782 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 381754017783 Citrate transporter; Region: CitMHS; pfam03600 381754017784 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 381754017785 hypothetical protein; Reviewed; Region: PRK09588 381754017786 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 381754017787 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381754017788 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 381754017789 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 381754017790 PhoU domain; Region: PhoU; pfam01895 381754017791 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 381754017792 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 381754017793 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 381754017794 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 381754017795 citrate-proton symporter; Provisional; Region: PRK15075 381754017796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754017797 putative substrate translocation pore; other site 381754017798 putative major fimbrial protein SthE; Provisional; Region: PRK15292 381754017799 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 381754017800 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 381754017801 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 381754017802 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 381754017803 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 381754017804 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 381754017805 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 381754017806 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754017807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754017808 active site 381754017809 phosphorylation site [posttranslational modification] 381754017810 intermolecular recognition site; other site 381754017811 dimerization interface [polypeptide binding]; other site 381754017812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754017813 Walker A motif; other site 381754017814 ATP binding site [chemical binding]; other site 381754017815 Walker B motif; other site 381754017816 arginine finger; other site 381754017817 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754017818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381754017819 dimerization interface [polypeptide binding]; other site 381754017820 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381754017821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381754017822 putative active site [active] 381754017823 heme pocket [chemical binding]; other site 381754017824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754017825 dimer interface [polypeptide binding]; other site 381754017826 phosphorylation site [posttranslational modification] 381754017827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754017828 ATP binding site [chemical binding]; other site 381754017829 Mg2+ binding site [ion binding]; other site 381754017830 G-X-G motif; other site 381754017831 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 381754017832 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 381754017833 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 381754017834 amidase catalytic site [active] 381754017835 Zn binding residues [ion binding]; other site 381754017836 substrate binding site [chemical binding]; other site 381754017837 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 381754017838 MarC family integral membrane protein; Region: MarC; cl00919 381754017839 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381754017840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381754017841 metal binding site [ion binding]; metal-binding site 381754017842 active site 381754017843 I-site; other site 381754017844 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 381754017845 putative catalytic site [active] 381754017846 putative metal binding site [ion binding]; other site 381754017847 putative phosphate binding site [ion binding]; other site 381754017848 putative catalytic site [active] 381754017849 putative phosphate binding site [ion binding]; other site 381754017850 putative metal binding site [ion binding]; other site 381754017851 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 381754017852 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 381754017853 catalytic residues [active] 381754017854 hinge region; other site 381754017855 alpha helical domain; other site 381754017856 Cytochrome c553 [Energy production and conversion]; Region: COG2863 381754017857 Cytochrome c; Region: Cytochrom_C; cl11414 381754017858 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 381754017859 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 381754017860 G1 box; other site 381754017861 GTP/Mg2+ binding site [chemical binding]; other site 381754017862 Switch I region; other site 381754017863 G2 box; other site 381754017864 G3 box; other site 381754017865 Switch II region; other site 381754017866 G4 box; other site 381754017867 G5 box; other site 381754017868 DNA polymerase I; Provisional; Region: PRK05755 381754017869 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 381754017870 active site 381754017871 metal binding site 1 [ion binding]; metal-binding site 381754017872 putative 5' ssDNA interaction site; other site 381754017873 metal binding site 3; metal-binding site 381754017874 metal binding site 2 [ion binding]; metal-binding site 381754017875 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 381754017876 putative DNA binding site [nucleotide binding]; other site 381754017877 putative metal binding site [ion binding]; other site 381754017878 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 381754017879 active site 381754017880 catalytic site [active] 381754017881 substrate binding site [chemical binding]; other site 381754017882 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 381754017883 active site 381754017884 DNA binding site [nucleotide binding] 381754017885 catalytic site [active] 381754017886 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 381754017887 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 381754017888 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 381754017889 putative active site [active] 381754017890 putative substrate binding site [chemical binding]; other site 381754017891 ATP binding site [chemical binding]; other site 381754017892 Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209 381754017893 TSCPD domain; Region: TSCPD; pfam12637 381754017894 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 381754017895 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 381754017896 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 381754017897 active site 381754017898 dimer interface [polypeptide binding]; other site 381754017899 effector binding site; other site 381754017900 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 381754017901 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 381754017902 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 381754017903 metal binding site [ion binding]; metal-binding site 381754017904 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 381754017905 Predicted transcriptional regulators [Transcription]; Region: COG1695 381754017906 metal binding site 2 [ion binding]; metal-binding site 381754017907 putative DNA binding helix; other site 381754017908 metal binding site 1 [ion binding]; metal-binding site 381754017909 dimer interface [polypeptide binding]; other site 381754017910 structural Zn2+ binding site [ion binding]; other site 381754017911 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 381754017912 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 381754017913 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 381754017914 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 381754017915 dimer interface [polypeptide binding]; other site 381754017916 putative PBP binding regions; other site 381754017917 ABC-ATPase subunit interface; other site 381754017918 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 381754017919 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 381754017920 Walker A/P-loop; other site 381754017921 ATP binding site [chemical binding]; other site 381754017922 Q-loop/lid; other site 381754017923 ABC transporter signature motif; other site 381754017924 Walker B; other site 381754017925 D-loop; other site 381754017926 H-loop/switch region; other site 381754017927 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 381754017928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381754017929 dimer interface [polypeptide binding]; other site 381754017930 conserved gate region; other site 381754017931 ABC-ATPase subunit interface; other site 381754017932 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 381754017933 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 381754017934 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 381754017935 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 381754017936 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 381754017937 putative active site [active] 381754017938 Isochorismatase family; Region: Isochorismatase; pfam00857 381754017939 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 381754017940 catalytic triad [active] 381754017941 conserved cis-peptide bond; other site 381754017942 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 381754017943 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381754017944 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 381754017945 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 381754017946 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 381754017947 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 381754017948 Haemagglutinin; Region: HIM; pfam05662 381754017949 YadA-like C-terminal region; Region: YadA; pfam03895 381754017950 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 381754017951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381754017952 active site 381754017953 phosphorylation site [posttranslational modification] 381754017954 intermolecular recognition site; other site 381754017955 dimerization interface [polypeptide binding]; other site 381754017956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381754017957 Walker A motif; other site 381754017958 ATP binding site [chemical binding]; other site 381754017959 Walker B motif; other site 381754017960 arginine finger; other site 381754017961 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381754017962 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 381754017963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381754017964 dimer interface [polypeptide binding]; other site 381754017965 phosphorylation site [posttranslational modification] 381754017966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381754017967 ATP binding site [chemical binding]; other site 381754017968 Mg2+ binding site [ion binding]; other site 381754017969 G-X-G motif; other site 381754017970 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381754017971 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 381754017972 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 381754017973 pyridoxamine kinase; Validated; Region: PRK05756 381754017974 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 381754017975 pyridoxal binding site [chemical binding]; other site 381754017976 dimer interface [polypeptide binding]; other site 381754017977 ATP binding site [chemical binding]; other site 381754017978 putative cation:proton antiport protein; Provisional; Region: PRK10669 381754017979 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 381754017980 TrkA-N domain; Region: TrkA_N; pfam02254 381754017981 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 381754017982 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 381754017983 classical (c) SDRs; Region: SDR_c; cd05233 381754017984 NAD(P) binding site [chemical binding]; other site 381754017985 active site 381754017986 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 381754017987 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381754017988 aminotransferase; Validated; Region: PRK07046 381754017989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381754017990 inhibitor-cofactor binding pocket; inhibition site 381754017991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381754017992 catalytic residue [active] 381754017993 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 381754017994 classical (c) SDRs; Region: SDR_c; cd05233 381754017995 NAD(P) binding site [chemical binding]; other site 381754017996 active site 381754017997 Transcriptional regulators [Transcription]; Region: GntR; COG1802 381754017998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381754017999 DNA-binding site [nucleotide binding]; DNA binding site 381754018000 FCD domain; Region: FCD; pfam07729 381754018001 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 381754018002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 381754018003 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 381754018004 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 381754018005 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 381754018006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381754018007 putative substrate translocation pore; other site 381754018008 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 381754018009 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 381754018010 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 381754018011 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 381754018012 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 381754018013 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 381754018014 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 381754018015 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 381754018016 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 381754018017 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 381754018018 AMIN domain; Region: AMIN; pfam11741 381754018019 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 381754018020 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 381754018021 active site 381754018022 metal binding site [ion binding]; metal-binding site 381754018023 putative GTP cyclohydrolase; Provisional; Region: PRK13674 381754018024 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 381754018025 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 381754018026 trimer interface [polypeptide binding]; other site 381754018027 active site 381754018028 dihydroorotase; Reviewed; Region: PRK09236 381754018029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 381754018030 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 381754018031 active site 381754018032 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 381754018033 Beta-lactamase; Region: Beta-lactamase; pfam00144 381754018034 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 381754018035 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 381754018036 DctM-like transporters; Region: DctM; pfam06808 381754018037 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 381754018038 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 381754018039 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 381754018040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381754018041 S-adenosylmethionine binding site [chemical binding]; other site 381754018042 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 381754018043 Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488 381754018044 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 381754018045 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 381754018046 glutaminase active site [active] 381754018047 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 381754018048 dimer interface [polypeptide binding]; other site 381754018049 active site 381754018050 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 381754018051 dimer interface [polypeptide binding]; other site 381754018052 active site 381754018053 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 381754018054 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 381754018055 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 381754018056 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 381754018057 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 381754018058 Substrate binding site; other site 381754018059 Mg++ binding site; other site 381754018060 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 381754018061 active site 381754018062 substrate binding site [chemical binding]; other site 381754018063 CoA binding site [chemical binding]; other site 381754018064 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 381754018065 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 381754018066 gamma subunit interface [polypeptide binding]; other site 381754018067 epsilon subunit interface [polypeptide binding]; other site 381754018068 LBP interface [polypeptide binding]; other site 381754018069 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 381754018070 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 381754018071 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 381754018072 alpha subunit interaction interface [polypeptide binding]; other site 381754018073 Walker A motif; other site 381754018074 ATP binding site [chemical binding]; other site 381754018075 Walker B motif; other site 381754018076 inhibitor binding site; inhibition site 381754018077 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 381754018078 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 381754018079 core domain interface [polypeptide binding]; other site 381754018080 delta subunit interface [polypeptide binding]; other site 381754018081 epsilon subunit interface [polypeptide binding]; other site 381754018082 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 381754018083 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 381754018084 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 381754018085 beta subunit interaction interface [polypeptide binding]; other site 381754018086 Walker A motif; other site 381754018087 ATP binding site [chemical binding]; other site 381754018088 Walker B motif; other site 381754018089 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 381754018090 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 381754018091 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 381754018092 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 381754018093 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 381754018094 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 381754018095 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 381754018096 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 381754018097 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 381754018098 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 381754018099 ParB-like nuclease domain; Region: ParBc; pfam02195 381754018100 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 381754018101 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754018102 P-loop; other site 381754018103 Magnesium ion binding site [ion binding]; other site 381754018104 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 381754018105 Magnesium ion binding site [ion binding]; other site 381754018106 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 381754018107 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 381754018108 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 381754018109 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 381754018110 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 381754018111 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 381754018112 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 381754018113 trmE is a tRNA modification GTPase; Region: trmE; cd04164 381754018114 G1 box; other site 381754018115 GTP/Mg2+ binding site [chemical binding]; other site 381754018116 Switch I region; other site 381754018117 G2 box; other site 381754018118 Switch II region; other site 381754018119 G3 box; other site 381754018120 G4 box; other site 381754018121 G5 box; other site 381754018122 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 381754018123 membrane protein insertase; Provisional; Region: PRK01318 381754018124 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 381754018125 ribonuclease P; Reviewed; Region: rnpA; PRK00396 381754018126 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399