-- dump date 20140620_004349 -- class Genbank::misc_feature -- table misc_feature_note -- id note 208964000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 208964000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 208964000003 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 208964000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964000005 Walker A motif; other site 208964000006 ATP binding site [chemical binding]; other site 208964000007 ATP-binding site [chemical binding]; other site 208964000008 Walker B motif; other site 208964000009 arginine finger; other site 208964000010 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 208964000011 DnaA box-binding interface [nucleotide binding]; other site 208964000012 DNA polymerase III subunit beta; Validated; Region: PRK05643 208964000013 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 208964000014 putative DNA binding surface [nucleotide binding]; other site 208964000015 dimer interface [polypeptide binding]; other site 208964000016 beta-clamp/clamp loader binding surface; other site 208964000017 beta-clamp/translesion DNA polymerase binding surface; other site 208964000018 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 208964000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964000020 Walker A/P-loop; other site 208964000021 ATP binding site [chemical binding]; other site 208964000022 Q-loop/lid; other site 208964000023 ABC transporter signature motif; other site 208964000024 Walker B; other site 208964000025 D-loop; other site 208964000026 H-loop/switch region; other site 208964000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 208964000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964000029 ATP binding site [chemical binding]; other site 208964000030 Mg2+ binding site [ion binding]; other site 208964000031 G-X-G motif; other site 208964000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 208964000033 anchoring element; other site 208964000034 dimer interface [polypeptide binding]; other site 208964000035 ATP binding site [chemical binding]; other site 208964000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 208964000037 active site 208964000038 putative metal-binding site [ion binding]; other site 208964000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 208964000040 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 208964000041 putative acyl-acceptor binding pocket; other site 208964000042 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 208964000043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964000044 active site 208964000045 motif I; other site 208964000046 motif II; other site 208964000047 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 208964000048 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 208964000049 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 208964000050 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 208964000051 dimer interface [polypeptide binding]; other site 208964000052 motif 1; other site 208964000053 active site 208964000054 motif 2; other site 208964000055 motif 3; other site 208964000056 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 208964000057 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 208964000058 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 208964000059 putative acyl-acceptor binding pocket; other site 208964000060 PilZ domain; Region: PilZ; pfam07238 208964000061 hypothetical protein; Provisional; Region: PRK11212 208964000062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964000063 TPR motif; other site 208964000064 TPR repeat; Region: TPR_11; pfam13414 208964000065 binding surface 208964000066 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 208964000067 TrkA-N domain; Region: TrkA_N; pfam02254 208964000068 TrkA-C domain; Region: TrkA_C; pfam02080 208964000069 TrkA-N domain; Region: TrkA_N; pfam02254 208964000070 TrkA-C domain; Region: TrkA_C; pfam02080 208964000071 16S rRNA methyltransferase B; Provisional; Region: PRK10901 208964000072 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 208964000073 putative RNA binding site [nucleotide binding]; other site 208964000074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964000075 S-adenosylmethionine binding site [chemical binding]; other site 208964000076 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 208964000077 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 208964000078 putative active site [active] 208964000079 substrate binding site [chemical binding]; other site 208964000080 putative cosubstrate binding site; other site 208964000081 catalytic site [active] 208964000082 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 208964000083 substrate binding site [chemical binding]; other site 208964000084 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 208964000085 active site 208964000086 catalytic residues [active] 208964000087 metal binding site [ion binding]; metal-binding site 208964000088 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 208964000089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964000090 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 208964000091 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 208964000092 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 208964000093 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 208964000094 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 208964000095 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 208964000096 NADP binding site [chemical binding]; other site 208964000097 dimer interface [polypeptide binding]; other site 208964000098 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 208964000099 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 208964000100 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 208964000101 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 208964000102 shikimate binding site; other site 208964000103 NAD(P) binding site [chemical binding]; other site 208964000104 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 208964000105 Zn binding site [ion binding]; other site 208964000106 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 208964000107 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 208964000108 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 208964000109 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 208964000110 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964000111 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 208964000112 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 208964000113 choline-sulfatase; Region: chol_sulfatase; TIGR03417 208964000114 Sulfatase; Region: Sulfatase; pfam00884 208964000115 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 208964000116 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 208964000117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000118 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 208964000119 dimerization interface [polypeptide binding]; other site 208964000120 substrate binding pocket [chemical binding]; other site 208964000121 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 208964000122 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964000123 putative binding surface; other site 208964000124 active site 208964000125 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964000126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964000127 active site 208964000128 phosphorylation site [posttranslational modification] 208964000129 intermolecular recognition site; other site 208964000130 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964000131 DNA binding residues [nucleotide binding] 208964000132 dimerization interface [polypeptide binding]; other site 208964000133 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 208964000134 substrate binding site [chemical binding]; other site 208964000135 active site 208964000136 catalytic residues [active] 208964000137 heterodimer interface [polypeptide binding]; other site 208964000138 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 208964000139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964000140 catalytic residue [active] 208964000141 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964000142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000143 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 208964000144 putative dimerization interface [polypeptide binding]; other site 208964000145 putative substrate binding pocket [chemical binding]; other site 208964000146 Dodecin; Region: Dodecin; pfam07311 208964000147 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 208964000148 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 208964000149 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 208964000150 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 208964000151 Surface antigen; Region: Bac_surface_Ag; pfam01103 208964000152 haemagglutination activity domain; Region: Haemagg_act; pfam05860 208964000153 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 208964000154 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 208964000155 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 208964000156 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 208964000157 Mg-dependent tRNAse of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins; Region: CDI_toxin_Bp1026b_like; cd13442 208964000158 inhibitor binding site [polypeptide binding]; inhibition site 208964000159 putative active site [active] 208964000160 putative metal binding site [ion binding]; other site 208964000161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 208964000162 MgtC family; Region: MgtC; pfam02308 208964000163 Predicted membrane protein [Function unknown]; Region: COG3174 208964000164 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 208964000165 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 208964000166 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 208964000167 switch II binding region; other site 208964000168 Rac1 P-loop interaction site [polypeptide binding]; other site 208964000169 GTP binding residues [chemical binding]; other site 208964000170 switch I binding region; other site 208964000171 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 208964000172 active site 208964000173 conformational flexibility of ligand binding pocket; other site 208964000174 ADP-ribosylating toxin turn-turn motif; other site 208964000175 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 208964000176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 208964000177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 208964000178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208964000179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964000180 non-specific DNA binding site [nucleotide binding]; other site 208964000181 salt bridge; other site 208964000182 sequence-specific DNA binding site [nucleotide binding]; other site 208964000183 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 208964000184 active site 208964000185 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 208964000186 dimer interface [polypeptide binding]; other site 208964000187 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 208964000188 Ligand Binding Site [chemical binding]; other site 208964000189 Molecular Tunnel; other site 208964000190 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 208964000191 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 208964000192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812 208964000193 transcriptional regulator; Provisional; Region: PRK10632 208964000194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000195 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964000196 putative effector binding pocket; other site 208964000197 dimerization interface [polypeptide binding]; other site 208964000198 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 208964000199 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 208964000200 catalytic residues [active] 208964000201 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 208964000202 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 208964000203 Predicted aminopeptidase [General function prediction only]; Region: COG4324 208964000204 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 208964000205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964000206 Eukaryotic phosphomannomutase; Region: PMM; cl17107 208964000207 active site 208964000208 motif I; other site 208964000209 motif II; other site 208964000210 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 208964000211 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 208964000212 trimer interface [polypeptide binding]; other site 208964000213 putative metal binding site [ion binding]; other site 208964000214 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 208964000215 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 208964000216 active site 208964000217 Zn binding site [ion binding]; other site 208964000218 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 208964000219 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 208964000220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964000221 FeS/SAM binding site; other site 208964000222 Uncharacterized conserved protein [Function unknown]; Region: COG1262 208964000223 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 208964000224 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 208964000225 FtsX-like permease family; Region: FtsX; pfam02687 208964000226 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208964000227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964000228 Walker A/P-loop; other site 208964000229 ATP binding site [chemical binding]; other site 208964000230 Q-loop/lid; other site 208964000231 ABC transporter signature motif; other site 208964000232 Walker B; other site 208964000233 D-loop; other site 208964000234 H-loop/switch region; other site 208964000235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 208964000236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 208964000237 active site 208964000238 ATP binding site [chemical binding]; other site 208964000239 substrate binding site [chemical binding]; other site 208964000240 activation loop (A-loop); other site 208964000241 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 208964000242 metal ion-dependent adhesion site (MIDAS); other site 208964000243 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 208964000244 active site 208964000245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SciT; COG3913 208964000246 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 208964000247 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 208964000248 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 208964000249 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 208964000250 hypothetical protein; Provisional; Region: PRK07033 208964000251 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 208964000252 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964000253 ligand binding site [chemical binding]; other site 208964000254 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 208964000255 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 208964000256 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 208964000257 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 208964000258 phosphopeptide binding site; other site 208964000259 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 208964000260 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 208964000261 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 208964000262 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 208964000263 Protein of unknown function (DUF796); Region: DUF796; pfam05638 208964000264 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 208964000265 ImpE protein; Region: ImpE; pfam07024 208964000266 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 208964000267 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 208964000268 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 208964000269 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 208964000270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964000271 Walker A motif; other site 208964000272 ATP binding site [chemical binding]; other site 208964000273 Walker B motif; other site 208964000274 arginine finger; other site 208964000275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964000276 Walker A motif; other site 208964000277 ATP binding site [chemical binding]; other site 208964000278 Walker B motif; other site 208964000279 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 208964000280 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 208964000281 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964000282 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964000283 PAAR motif; Region: PAAR_motif; pfam05488 208964000284 Putative toxin 61; Region: Toxin_61; pfam15538 208964000285 Uncharacterized conserved protein [Function unknown]; Region: COG5435 208964000286 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 208964000287 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964000288 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964000289 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 208964000290 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 208964000291 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 208964000292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5351 208964000293 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 208964000294 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 208964000295 active site 208964000296 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 208964000297 GHH signature containing HNH/Endo VII superfamily nuclease toxin 2; Region: Tox-GHH2; pfam15635 208964000298 conserved hypothetical protein; Region: TIGR02270 208964000299 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 208964000300 active site clefts [active] 208964000301 zinc binding site [ion binding]; other site 208964000302 dimer interface [polypeptide binding]; other site 208964000303 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 208964000304 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 208964000305 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964000306 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 208964000307 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 208964000308 Cupredoxin superfamily; Region: Cupredoxin; cl19115 208964000309 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964000310 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964000311 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 208964000312 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 208964000313 Subunit I/III interface [polypeptide binding]; other site 208964000314 D-pathway; other site 208964000315 Subunit I/VIIc interface [polypeptide binding]; other site 208964000316 Subunit I/IV interface [polypeptide binding]; other site 208964000317 Subunit I/II interface [polypeptide binding]; other site 208964000318 Low-spin heme (heme a) binding site [chemical binding]; other site 208964000319 Subunit I/VIIa interface [polypeptide binding]; other site 208964000320 Subunit I/VIa interface [polypeptide binding]; other site 208964000321 Dimer interface; other site 208964000322 Putative water exit pathway; other site 208964000323 Binuclear center (heme a3/CuB) [ion binding]; other site 208964000324 K-pathway; other site 208964000325 Subunit I/Vb interface [polypeptide binding]; other site 208964000326 Putative proton exit pathway; other site 208964000327 Subunit I/VIb interface; other site 208964000328 Subunit I/VIc interface [polypeptide binding]; other site 208964000329 Electron transfer pathway; other site 208964000330 Subunit I/VIIIb interface [polypeptide binding]; other site 208964000331 Subunit I/VIIb interface [polypeptide binding]; other site 208964000332 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 208964000333 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 208964000334 Subunit III/VIIa interface [polypeptide binding]; other site 208964000335 Phospholipid binding site [chemical binding]; other site 208964000336 Subunit I/III interface [polypeptide binding]; other site 208964000337 Subunit III/VIb interface [polypeptide binding]; other site 208964000338 Subunit III/VIa interface; other site 208964000339 Subunit III/Vb interface [polypeptide binding]; other site 208964000340 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 208964000341 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 208964000342 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 208964000343 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 208964000344 putative active site [active] 208964000345 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 208964000346 Cu(I) binding site [ion binding]; other site 208964000347 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208964000348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964000349 Coenzyme A binding pocket [chemical binding]; other site 208964000350 Predicted transcriptional regulators [Transcription]; Region: COG1733 208964000351 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 208964000352 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 208964000353 putative NAD(P) binding site [chemical binding]; other site 208964000354 active site 208964000355 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 208964000356 putative catalytic residue [active] 208964000357 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 208964000358 Transcriptional regulators [Transcription]; Region: FadR; COG2186 208964000359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964000360 DNA-binding site [nucleotide binding]; DNA binding site 208964000361 FCD domain; Region: FCD; pfam07729 208964000362 Transcriptional regulators [Transcription]; Region: GntR; COG1802 208964000363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 208964000364 DNA-binding site [nucleotide binding]; DNA binding site 208964000365 FCD domain; Region: FCD; pfam07729 208964000366 Aegerolysin; Region: Aegerolysin; pfam06355 208964000367 transcriptional regulator; Provisional; Region: PRK10632 208964000368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000369 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964000370 putative effector binding pocket; other site 208964000371 dimerization interface [polypeptide binding]; other site 208964000372 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 208964000373 Predicted transcriptional regulator [Transcription]; Region: COG3905 208964000374 Water Stress and Hypersensitive response; Region: WHy; smart00769 208964000375 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 208964000376 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 208964000377 PhnA protein; Region: PhnA; pfam03831 208964000378 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 208964000379 Spore germination protein; Region: Spore_permease; cl17796 208964000380 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 208964000381 tetrameric interface [polypeptide binding]; other site 208964000382 NAD binding site [chemical binding]; other site 208964000383 catalytic residues [active] 208964000384 Cupin domain; Region: Cupin_2; cl17218 208964000385 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964000386 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964000387 inhibitor-cofactor binding pocket; inhibition site 208964000388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964000389 catalytic residue [active] 208964000390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964000393 dimerization interface [polypeptide binding]; other site 208964000394 guanine deaminase; Provisional; Region: PRK09228 208964000395 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 208964000396 active site 208964000397 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 208964000398 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 208964000399 Walker A/P-loop; other site 208964000400 ATP binding site [chemical binding]; other site 208964000401 Q-loop/lid; other site 208964000402 ABC transporter signature motif; other site 208964000403 Walker B; other site 208964000404 D-loop; other site 208964000405 H-loop/switch region; other site 208964000406 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 208964000407 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 208964000408 TM-ABC transporter signature motif; other site 208964000409 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 208964000410 TM-ABC transporter signature motif; other site 208964000411 peroxiredoxin; Region: AhpC; TIGR03137 208964000412 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 208964000413 dimer interface [polypeptide binding]; other site 208964000414 decamer (pentamer of dimers) interface [polypeptide binding]; other site 208964000415 catalytic triad [active] 208964000416 peroxidatic and resolving cysteines [active] 208964000417 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 208964000418 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 208964000419 catalytic residue [active] 208964000420 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 208964000421 catalytic residues [active] 208964000422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964000423 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964000424 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 208964000425 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 208964000426 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 208964000427 active site 208964000428 putative substrate binding pocket [chemical binding]; other site 208964000429 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 208964000430 active site 208964000431 tetramer interface [polypeptide binding]; other site 208964000432 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 208964000433 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 208964000434 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 208964000435 putative ligand binding site [chemical binding]; other site 208964000436 oxidase reductase; Provisional; Region: PTZ00273 208964000437 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 208964000438 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 208964000439 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 208964000440 active site 208964000441 purine riboside binding site [chemical binding]; other site 208964000442 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 208964000443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964000444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964000445 DNA binding residues [nucleotide binding] 208964000446 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964000447 FecR protein; Region: FecR; pfam04773 208964000448 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964000449 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 208964000450 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964000451 N-terminal plug; other site 208964000452 ligand-binding site [chemical binding]; other site 208964000453 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 208964000454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964000456 dimerization interface [polypeptide binding]; other site 208964000457 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 208964000458 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 208964000459 active site 208964000460 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 208964000461 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 208964000462 heterodimer interface [polypeptide binding]; other site 208964000463 active site 208964000464 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 208964000465 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 208964000466 Bacterial transcriptional regulator; Region: IclR; pfam01614 208964000467 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964000468 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964000469 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964000470 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964000471 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964000472 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964000473 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 208964000474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000476 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964000477 putative effector binding pocket; other site 208964000478 dimerization interface [polypeptide binding]; other site 208964000479 outer membrane porin, OprD family; Region: OprD; pfam03573 208964000480 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964000481 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964000482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964000483 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 208964000484 Nucleoside-binding outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: Tsx; COG3248 208964000485 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964000486 xanthine permease; Region: pbuX; TIGR03173 208964000487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964000488 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 208964000489 Uncharacterized conserved protein [Function unknown]; Region: COG1739 208964000490 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 208964000491 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 208964000492 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 208964000493 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964000494 metal binding site [ion binding]; metal-binding site 208964000495 active site 208964000496 I-site; other site 208964000497 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 208964000498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964000499 dimerization interface [polypeptide binding]; other site 208964000500 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 208964000501 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 208964000502 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 208964000503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964000504 active site 208964000505 phosphorylation site [posttranslational modification] 208964000506 intermolecular recognition site; other site 208964000507 dimerization interface [polypeptide binding]; other site 208964000508 CheB methylesterase; Region: CheB_methylest; pfam01339 208964000509 CheD chemotactic sensory transduction; Region: CheD; cl00810 208964000510 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 208964000511 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 208964000512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964000513 S-adenosylmethionine binding site [chemical binding]; other site 208964000514 PAS domain; Region: PAS_8; pfam13188 208964000515 PAS fold; Region: PAS_4; pfam08448 208964000516 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964000517 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964000518 dimer interface [polypeptide binding]; other site 208964000519 putative CheW interface [polypeptide binding]; other site 208964000520 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 208964000521 putative CheA interaction surface; other site 208964000522 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 208964000523 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964000524 putative binding surface; other site 208964000525 active site 208964000526 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 208964000527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964000528 ATP binding site [chemical binding]; other site 208964000529 Mg2+ binding site [ion binding]; other site 208964000530 G-X-G motif; other site 208964000531 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 208964000532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964000533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964000534 active site 208964000535 phosphorylation site [posttranslational modification] 208964000536 intermolecular recognition site; other site 208964000537 dimerization interface [polypeptide binding]; other site 208964000538 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964000539 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 208964000540 putative CheW interface [polypeptide binding]; other site 208964000541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000543 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964000544 putative effector binding pocket; other site 208964000545 dimerization interface [polypeptide binding]; other site 208964000546 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 208964000547 classical (c) SDRs; Region: SDR_c; cd05233 208964000548 NAD(P) binding site [chemical binding]; other site 208964000549 active site 208964000550 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 208964000551 Sulfatase; Region: Sulfatase; pfam00884 208964000552 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 208964000553 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 208964000554 Walker A/P-loop; other site 208964000555 ATP binding site [chemical binding]; other site 208964000556 Q-loop/lid; other site 208964000557 ABC transporter signature motif; other site 208964000558 Walker B; other site 208964000559 D-loop; other site 208964000560 H-loop/switch region; other site 208964000561 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964000562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000563 dimer interface [polypeptide binding]; other site 208964000564 conserved gate region; other site 208964000565 putative PBP binding loops; other site 208964000566 ABC-ATPase subunit interface; other site 208964000567 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964000568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000569 dimer interface [polypeptide binding]; other site 208964000570 putative PBP binding loops; other site 208964000571 ABC-ATPase subunit interface; other site 208964000572 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 208964000573 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 208964000574 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 208964000575 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 208964000576 substrate binding pocket [chemical binding]; other site 208964000577 active site 208964000578 iron coordination sites [ion binding]; other site 208964000579 Predicted permeases [General function prediction only]; Region: COG0679 208964000580 outer membrane porin, OprD family; Region: OprD; pfam03573 208964000581 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 208964000582 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 208964000583 active site 208964000584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964000587 dimerization interface [polypeptide binding]; other site 208964000588 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964000589 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 208964000590 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 208964000591 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 208964000592 active site 208964000593 iron coordination sites [ion binding]; other site 208964000594 substrate binding pocket [chemical binding]; other site 208964000595 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 208964000596 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 208964000597 active site 208964000598 iron coordination sites [ion binding]; other site 208964000599 substrate binding pocket [chemical binding]; other site 208964000600 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 208964000601 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 208964000602 ligand binding site [chemical binding]; other site 208964000603 homodimer interface [polypeptide binding]; other site 208964000604 NAD(P) binding site [chemical binding]; other site 208964000605 trimer interface B [polypeptide binding]; other site 208964000606 trimer interface A [polypeptide binding]; other site 208964000607 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 208964000608 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 208964000609 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 208964000610 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 208964000611 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 208964000612 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 208964000613 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 208964000614 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 208964000615 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208964000616 amidase; Provisional; Region: PRK07486 208964000617 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208964000618 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964000619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000620 dimer interface [polypeptide binding]; other site 208964000621 conserved gate region; other site 208964000622 putative PBP binding loops; other site 208964000623 ABC-ATPase subunit interface; other site 208964000624 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964000625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000626 dimer interface [polypeptide binding]; other site 208964000627 conserved gate region; other site 208964000628 putative PBP binding loops; other site 208964000629 ABC-ATPase subunit interface; other site 208964000630 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 208964000631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964000632 Walker A/P-loop; other site 208964000633 ATP binding site [chemical binding]; other site 208964000634 Q-loop/lid; other site 208964000635 ABC transporter signature motif; other site 208964000636 Walker B; other site 208964000637 D-loop; other site 208964000638 H-loop/switch region; other site 208964000639 TOBE domain; Region: TOBE_2; pfam08402 208964000640 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964000641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000642 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964000643 dimerization interface [polypeptide binding]; other site 208964000644 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 208964000645 Coenzyme A transferase; Region: CoA_trans; cl17247 208964000646 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 208964000647 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 208964000648 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 208964000649 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 208964000650 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 208964000651 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 208964000652 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 208964000653 Malonate transporter MadL subunit; Region: MadL; pfam03817 208964000654 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 208964000655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000657 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 208964000658 putative dimerization interface [polypeptide binding]; other site 208964000659 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000660 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000661 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 208964000662 putative substrate binding pocket [chemical binding]; other site 208964000663 dimerization interface [polypeptide binding]; other site 208964000664 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 208964000665 NAD(P) binding site [chemical binding]; other site 208964000666 catalytic residues [active] 208964000667 Amino acid permease; Region: AA_permease_2; pfam13520 208964000668 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964000669 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964000670 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964000671 inhibitor-cofactor binding pocket; inhibition site 208964000672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964000673 catalytic residue [active] 208964000674 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208964000675 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 208964000676 inhibitor site; inhibition site 208964000677 active site 208964000678 dimer interface [polypeptide binding]; other site 208964000679 catalytic residue [active] 208964000680 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 208964000681 intersubunit interface [polypeptide binding]; other site 208964000682 active site 208964000683 Zn2+ binding site [ion binding]; other site 208964000684 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208964000685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964000686 non-specific DNA binding site [nucleotide binding]; other site 208964000687 salt bridge; other site 208964000688 sequence-specific DNA binding site [nucleotide binding]; other site 208964000689 Cupin domain; Region: Cupin_2; pfam07883 208964000690 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 208964000691 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 208964000692 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 208964000693 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964000694 dimer interface [polypeptide binding]; other site 208964000695 active site 208964000696 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 208964000697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964000698 putative substrate translocation pore; other site 208964000699 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 208964000700 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 208964000701 tetramer interface [polypeptide binding]; other site 208964000702 active site 208964000703 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 208964000704 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964000705 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 208964000706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964000709 dimerization interface [polypeptide binding]; other site 208964000710 benzoate transport; Region: 2A0115; TIGR00895 208964000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964000712 putative substrate translocation pore; other site 208964000713 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208964000714 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 208964000715 Bacterial transcriptional regulator; Region: IclR; pfam01614 208964000716 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208964000717 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208964000718 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 208964000719 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 208964000720 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 208964000721 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964000722 EamA-like transporter family; Region: EamA; pfam00892 208964000723 outer membrane porin, OprD family; Region: OprD; pfam03573 208964000724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964000725 D-galactonate transporter; Region: 2A0114; TIGR00893 208964000726 putative substrate translocation pore; other site 208964000727 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 208964000728 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 208964000729 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 208964000730 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 208964000731 dimer interface [polypeptide binding]; other site 208964000732 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 208964000733 active site 208964000734 Fe binding site [ion binding]; other site 208964000735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964000736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964000737 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 208964000738 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 208964000739 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 208964000740 shikimate binding site; other site 208964000741 NAD(P) binding site [chemical binding]; other site 208964000742 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 208964000743 trimer interface [polypeptide binding]; other site 208964000744 active site 208964000745 dimer interface [polypeptide binding]; other site 208964000746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964000747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964000748 putative substrate translocation pore; other site 208964000749 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 208964000750 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 208964000751 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964000752 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964000753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964000754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 208964000755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964000756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208964000757 Coenzyme A binding pocket [chemical binding]; other site 208964000758 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 208964000759 FOG: CBS domain [General function prediction only]; Region: COG0517 208964000760 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 208964000761 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964000762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964000763 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 208964000764 Predicted membrane protein [Function unknown]; Region: COG3619 208964000765 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 208964000766 putative transposase OrfB; Reviewed; Region: PHA02517 208964000767 Integrase core domain; Region: rve; pfam00665 208964000768 Integrase core domain; Region: rve_3; pfam13683 208964000769 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 208964000770 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 208964000771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 208964000772 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964000773 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964000774 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 208964000775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 208964000776 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 208964000777 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 208964000778 tetramerization interface [polypeptide binding]; other site 208964000779 NAD(P) binding site [chemical binding]; other site 208964000780 catalytic residues [active] 208964000781 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964000782 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964000783 inhibitor-cofactor binding pocket; inhibition site 208964000784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964000785 catalytic residue [active] 208964000786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964000787 active site 208964000788 phosphorylation site [posttranslational modification] 208964000789 intermolecular recognition site; other site 208964000790 dimerization interface [polypeptide binding]; other site 208964000791 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 208964000792 HDOD domain; Region: HDOD; pfam08668 208964000793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964000794 DNA-binding site [nucleotide binding]; DNA binding site 208964000795 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 208964000796 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964000797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964000798 homodimer interface [polypeptide binding]; other site 208964000799 catalytic residue [active] 208964000800 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 208964000801 Uncharacterized conserved protein [Function unknown]; Region: COG2128 208964000802 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 208964000803 Uncharacterized conserved protein [Function unknown]; Region: COG1359 208964000804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000806 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 208964000807 substrate binding pocket [chemical binding]; other site 208964000808 dimerization interface [polypeptide binding]; other site 208964000809 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 208964000810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964000811 putative substrate translocation pore; other site 208964000812 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 208964000813 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208964000814 ligand binding site [chemical binding]; other site 208964000815 flexible hinge region; other site 208964000816 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 208964000817 putative switch regulator; other site 208964000818 non-specific DNA interactions [nucleotide binding]; other site 208964000819 DNA binding site [nucleotide binding] 208964000820 sequence specific DNA binding site [nucleotide binding]; other site 208964000821 putative cAMP binding site [chemical binding]; other site 208964000822 Predicted membrane protein [Function unknown]; Region: COG4539 208964000823 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 208964000824 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 208964000825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964000826 dimerization interface [polypeptide binding]; other site 208964000827 putative DNA binding site [nucleotide binding]; other site 208964000828 putative Zn2+ binding site [ion binding]; other site 208964000829 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 208964000830 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 208964000831 Walker A/P-loop; other site 208964000832 ATP binding site [chemical binding]; other site 208964000833 Q-loop/lid; other site 208964000834 ABC transporter signature motif; other site 208964000835 Walker B; other site 208964000836 D-loop; other site 208964000837 H-loop/switch region; other site 208964000838 TOBE-like domain; Region: TOBE_3; pfam12857 208964000839 sulfate transport protein; Provisional; Region: cysT; CHL00187 208964000840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000841 dimer interface [polypeptide binding]; other site 208964000842 conserved gate region; other site 208964000843 putative PBP binding loops; other site 208964000844 ABC-ATPase subunit interface; other site 208964000845 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 208964000846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000847 dimer interface [polypeptide binding]; other site 208964000848 conserved gate region; other site 208964000849 putative PBP binding loops; other site 208964000850 ABC-ATPase subunit interface; other site 208964000851 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 208964000852 Uncharacterized small protein [Function unknown]; Region: COG5583 208964000853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964000854 PAS fold; Region: PAS_3; pfam08447 208964000855 putative active site [active] 208964000856 heme pocket [chemical binding]; other site 208964000857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964000858 PAS domain; Region: PAS_9; pfam13426 208964000859 putative active site [active] 208964000860 heme pocket [chemical binding]; other site 208964000861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964000862 metal binding site [ion binding]; metal-binding site 208964000863 active site 208964000864 I-site; other site 208964000865 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964000866 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 208964000867 Di-iron ligands [ion binding]; other site 208964000868 Transposase; Region: DDE_Tnp_ISL3; pfam01610 208964000869 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 208964000870 Na binding site [ion binding]; other site 208964000871 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 208964000872 oligomer interface [polypeptide binding]; other site 208964000873 putative active site [active] 208964000874 Mn binding site [ion binding]; other site 208964000875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964000876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964000877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964000878 dimerization interface [polypeptide binding]; other site 208964000879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964000880 PAS fold; Region: PAS_3; pfam08447 208964000881 putative active site [active] 208964000882 heme pocket [chemical binding]; other site 208964000883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964000884 metal binding site [ion binding]; metal-binding site 208964000885 active site 208964000886 I-site; other site 208964000887 outer membrane porin, OprD family; Region: OprD; pfam03573 208964000888 agmatine deiminase; Provisional; Region: PRK13551 208964000889 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 208964000890 putative active site; other site 208964000891 catalytic triad [active] 208964000892 putative dimer interface [polypeptide binding]; other site 208964000893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964000894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964000895 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208964000896 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208964000897 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 208964000898 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208964000899 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 208964000900 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 208964000901 catalytic triad [active] 208964000902 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208964000903 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208964000904 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964000905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964000906 inhibitor-cofactor binding pocket; inhibition site 208964000907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964000908 catalytic residue [active] 208964000909 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 208964000910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 208964000911 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 208964000912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964000913 Walker A/P-loop; other site 208964000914 ATP binding site [chemical binding]; other site 208964000915 Q-loop/lid; other site 208964000916 ABC transporter signature motif; other site 208964000917 Walker B; other site 208964000918 D-loop; other site 208964000919 H-loop/switch region; other site 208964000920 TOBE domain; Region: TOBE_2; pfam08402 208964000921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000922 dimer interface [polypeptide binding]; other site 208964000923 conserved gate region; other site 208964000924 putative PBP binding loops; other site 208964000925 ABC-ATPase subunit interface; other site 208964000926 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964000927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000928 dimer interface [polypeptide binding]; other site 208964000929 conserved gate region; other site 208964000930 putative PBP binding loops; other site 208964000931 ABC-ATPase subunit interface; other site 208964000932 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 208964000933 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 208964000934 active site 208964000935 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964000936 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964000937 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 208964000938 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 208964000939 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964000940 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964000941 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 208964000942 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 208964000943 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 208964000944 Uncharacterized conserved protein [Function unknown]; Region: COG1683 208964000945 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964000946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000947 dimer interface [polypeptide binding]; other site 208964000948 conserved gate region; other site 208964000949 putative PBP binding loops; other site 208964000950 ABC-ATPase subunit interface; other site 208964000951 cystine transporter subunit; Provisional; Region: PRK11260 208964000952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964000953 substrate binding pocket [chemical binding]; other site 208964000954 membrane-bound complex binding site; other site 208964000955 hinge residues; other site 208964000956 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 208964000957 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 208964000958 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 208964000959 ligand binding site [chemical binding]; other site 208964000960 NAD binding site [chemical binding]; other site 208964000961 tetramer interface [polypeptide binding]; other site 208964000962 catalytic site [active] 208964000963 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 208964000964 L-serine binding site [chemical binding]; other site 208964000965 ACT domain interface; other site 208964000966 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 208964000967 FAD binding domain; Region: FAD_binding_4; pfam01565 208964000968 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 208964000969 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 208964000970 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 208964000971 SdiA-regulated; Region: SdiA-regulated; cd09971 208964000972 putative active site [active] 208964000973 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 208964000974 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 208964000975 active site 208964000976 Zn binding site [ion binding]; other site 208964000977 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208964000978 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964000979 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208964000980 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964000981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000982 dimer interface [polypeptide binding]; other site 208964000983 conserved gate region; other site 208964000984 putative PBP binding loops; other site 208964000985 ABC-ATPase subunit interface; other site 208964000986 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964000987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964000988 dimer interface [polypeptide binding]; other site 208964000989 conserved gate region; other site 208964000990 putative PBP binding loops; other site 208964000991 ABC-ATPase subunit interface; other site 208964000992 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 208964000993 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 208964000994 Walker A/P-loop; other site 208964000995 ATP binding site [chemical binding]; other site 208964000996 Q-loop/lid; other site 208964000997 ABC transporter signature motif; other site 208964000998 Walker B; other site 208964000999 D-loop; other site 208964001000 H-loop/switch region; other site 208964001001 TOBE domain; Region: TOBE_2; pfam08402 208964001002 SdiA-regulated; Region: SdiA-regulated; cd09971 208964001003 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 208964001004 putative active site [active] 208964001005 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 208964001006 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 208964001007 metal binding site [ion binding]; metal-binding site 208964001008 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 208964001009 Uncharacterized conserved protein [Function unknown]; Region: COG3422 208964001010 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 208964001011 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 208964001012 tetramer (dimer of dimers) interface [polypeptide binding]; other site 208964001013 active site 208964001014 dimer interface [polypeptide binding]; other site 208964001015 threonine dehydratase; Reviewed; Region: PRK09224 208964001016 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 208964001017 tetramer interface [polypeptide binding]; other site 208964001018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964001019 catalytic residue [active] 208964001020 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 208964001021 putative Ile/Val binding site [chemical binding]; other site 208964001022 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 208964001023 putative Ile/Val binding site [chemical binding]; other site 208964001024 Predicted integral membrane protein [Function unknown]; Region: COG5528 208964001025 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 208964001026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964001027 NAD(P) binding site [chemical binding]; other site 208964001028 active site 208964001029 DoxX-like family; Region: DoxX_3; pfam13781 208964001030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964001031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964001032 putative substrate translocation pore; other site 208964001033 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 208964001034 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 208964001035 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 208964001036 putative active site [active] 208964001037 Ap4A binding site [chemical binding]; other site 208964001038 nudix motif; other site 208964001039 putative metal binding site [ion binding]; other site 208964001040 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 208964001041 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 208964001042 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 208964001043 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 208964001044 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 208964001045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001046 PAS fold; Region: PAS_3; pfam08447 208964001047 putative active site [active] 208964001048 heme pocket [chemical binding]; other site 208964001049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964001050 metal binding site [ion binding]; metal-binding site 208964001051 active site 208964001052 I-site; other site 208964001053 Uncharacterized conserved protein [Function unknown]; Region: COG3332 208964001054 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 208964001055 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 208964001056 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 208964001057 dimerization interface [polypeptide binding]; other site 208964001058 active site 208964001059 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 208964001060 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 208964001061 G1 box; other site 208964001062 GTP/Mg2+ binding site [chemical binding]; other site 208964001063 G2 box; other site 208964001064 Switch I region; other site 208964001065 G3 box; other site 208964001066 Switch II region; other site 208964001067 G4 box; other site 208964001068 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 208964001069 G5 box; other site 208964001070 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 208964001071 Transport protein; Region: actII; TIGR00833 208964001072 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 208964001073 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 208964001074 putative active site [active] 208964001075 catalytic site [active] 208964001076 putative metal binding site [ion binding]; other site 208964001077 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 208964001078 folate binding site [chemical binding]; other site 208964001079 NADP+ binding site [chemical binding]; other site 208964001080 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 208964001081 active site 208964001082 metal binding site [ion binding]; metal-binding site 208964001083 homotetramer interface [polypeptide binding]; other site 208964001084 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 208964001085 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964001086 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 208964001087 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 208964001088 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 208964001089 putative RNA binding site [nucleotide binding]; other site 208964001090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964001091 S-adenosylmethionine binding site [chemical binding]; other site 208964001092 intracellular protease, PfpI family; Region: PfpI; TIGR01382 208964001093 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 208964001094 proposed catalytic triad [active] 208964001095 conserved cys residue [active] 208964001096 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 208964001097 HDOD domain; Region: HDOD; pfam08668 208964001098 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 208964001099 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 208964001100 DNA binding site [nucleotide binding] 208964001101 catalytic residue [active] 208964001102 H2TH interface [polypeptide binding]; other site 208964001103 putative catalytic residues [active] 208964001104 turnover-facilitating residue; other site 208964001105 intercalation triad [nucleotide binding]; other site 208964001106 8OG recognition residue [nucleotide binding]; other site 208964001107 putative reading head residues; other site 208964001108 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 208964001109 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 208964001110 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 208964001111 putative acyl-acceptor binding pocket; other site 208964001112 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 208964001113 Sel1-like repeats; Region: SEL1; smart00671 208964001114 Sel1-like repeats; Region: SEL1; smart00671 208964001115 Sel1-like repeats; Region: SEL1; smart00671 208964001116 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 208964001117 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 208964001118 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 208964001119 active site 208964001120 (T/H)XGH motif; other site 208964001121 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 208964001122 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 208964001123 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 208964001124 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 208964001125 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 208964001126 NAD(P) binding site [chemical binding]; other site 208964001127 catalytic residues [active] 208964001128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964001129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964001130 Bacterial transcriptional repressor; Region: TetR; pfam13972 208964001131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964001132 Coenzyme A binding pocket [chemical binding]; other site 208964001133 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 208964001134 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964001135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964001136 S-adenosylmethionine binding site [chemical binding]; other site 208964001137 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 208964001138 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 208964001139 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 208964001140 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 208964001141 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 208964001142 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 208964001143 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 208964001144 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 208964001145 P loop; other site 208964001146 GTP binding site [chemical binding]; other site 208964001147 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 208964001148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964001149 Walker A/P-loop; other site 208964001150 ATP binding site [chemical binding]; other site 208964001151 Q-loop/lid; other site 208964001152 ABC transporter signature motif; other site 208964001153 Walker B; other site 208964001154 D-loop; other site 208964001155 H-loop/switch region; other site 208964001156 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 208964001157 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 208964001158 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 208964001159 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 208964001160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964001161 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 208964001162 DNA binding residues [nucleotide binding] 208964001163 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 208964001164 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 208964001165 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 208964001166 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 208964001167 thiS-thiF/thiG interaction site; other site 208964001168 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 208964001169 ThiS interaction site; other site 208964001170 putative active site [active] 208964001171 tetramer interface [polypeptide binding]; other site 208964001172 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 208964001173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964001174 S-adenosylmethionine binding site [chemical binding]; other site 208964001175 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 208964001176 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 208964001177 HemN family oxidoreductase; Provisional; Region: PRK05660 208964001178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964001179 FeS/SAM binding site; other site 208964001180 HemN C-terminal domain; Region: HemN_C; pfam06969 208964001181 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 208964001182 active site 208964001183 dimerization interface [polypeptide binding]; other site 208964001184 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 208964001185 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964001186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964001187 S-adenosylmethionine binding site [chemical binding]; other site 208964001188 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 208964001189 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 208964001190 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 208964001191 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 208964001192 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 208964001193 G3 box; other site 208964001194 Switch II region; other site 208964001195 GTP/Mg2+ binding site [chemical binding]; other site 208964001196 G4 box; other site 208964001197 G5 box; other site 208964001198 YGGT family; Region: YGGT; pfam02325 208964001199 YGGT family; Region: YGGT; pfam02325 208964001200 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 208964001201 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 208964001202 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 208964001203 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 208964001204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208964001205 catalytic residue [active] 208964001206 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 208964001207 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 208964001208 Walker A motif; other site 208964001209 ATP binding site [chemical binding]; other site 208964001210 Walker B motif; other site 208964001211 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 208964001212 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 208964001213 Walker A motif; other site 208964001214 ATP binding site [chemical binding]; other site 208964001215 Walker B motif; other site 208964001216 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 208964001217 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 208964001218 TM2 domain; Region: TM2; cl00984 208964001219 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 208964001220 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 208964001221 dimer interface [polypeptide binding]; other site 208964001222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964001223 catalytic residue [active] 208964001224 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 208964001225 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 208964001226 homodimer interface [polypeptide binding]; other site 208964001227 substrate-cofactor binding pocket; other site 208964001228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964001229 catalytic residue [active] 208964001230 dihydroorotase; Validated; Region: pyrC; PRK09357 208964001231 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 208964001232 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 208964001233 active site 208964001234 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 208964001235 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 208964001236 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 208964001237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964001238 active site 208964001239 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 208964001240 hypothetical protein; Validated; Region: PRK00228 208964001241 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 208964001242 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 208964001243 glutathione synthetase; Provisional; Region: PRK05246 208964001244 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 208964001245 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 208964001246 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964001247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964001248 active site 208964001249 phosphorylation site [posttranslational modification] 208964001250 intermolecular recognition site; other site 208964001251 dimerization interface [polypeptide binding]; other site 208964001252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964001253 active site 208964001254 phosphorylation site [posttranslational modification] 208964001255 intermolecular recognition site; other site 208964001256 dimerization interface [polypeptide binding]; other site 208964001257 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 208964001258 putative CheA interaction surface; other site 208964001259 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 208964001260 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964001261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964001262 dimer interface [polypeptide binding]; other site 208964001263 putative CheW interface [polypeptide binding]; other site 208964001264 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 208964001265 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 208964001266 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 208964001267 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964001268 putative binding surface; other site 208964001269 active site 208964001270 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964001271 putative binding surface; other site 208964001272 active site 208964001273 Hpt domain; Region: Hpt; pfam01627 208964001274 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964001275 putative binding surface; other site 208964001276 active site 208964001277 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 208964001278 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964001279 putative binding surface; other site 208964001280 active site 208964001281 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964001282 putative binding surface; other site 208964001283 active site 208964001284 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 208964001285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964001286 ATP binding site [chemical binding]; other site 208964001287 Mg2+ binding site [ion binding]; other site 208964001288 G-X-G motif; other site 208964001289 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 208964001290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964001291 active site 208964001292 phosphorylation site [posttranslational modification] 208964001293 intermolecular recognition site; other site 208964001294 dimerization interface [polypeptide binding]; other site 208964001295 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 208964001296 CheB methylesterase; Region: CheB_methylest; pfam01339 208964001297 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 208964001298 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964001299 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964001300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964001301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964001302 LysE type translocator; Region: LysE; pfam01810 208964001303 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 208964001304 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964001305 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964001306 inhibitor-cofactor binding pocket; inhibition site 208964001307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964001308 catalytic residue [active] 208964001309 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 208964001310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208964001311 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 208964001312 hypothetical protein; Provisional; Region: PRK03757 208964001313 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208964001314 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964001315 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 208964001316 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964001317 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964001318 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 208964001319 MMPL family; Region: MMPL; cl14618 208964001320 MMPL family; Region: MMPL; cl14618 208964001321 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 208964001322 Outer membrane efflux protein; Region: OEP; pfam02321 208964001323 Outer membrane efflux protein; Region: OEP; pfam02321 208964001324 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 208964001325 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208964001326 ATP binding site [chemical binding]; other site 208964001327 Mg++ binding site [ion binding]; other site 208964001328 motif III; other site 208964001329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964001330 nucleotide binding region [chemical binding]; other site 208964001331 ATP-binding site [chemical binding]; other site 208964001332 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 208964001333 FAD binding site [chemical binding]; other site 208964001334 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 208964001335 HD domain; Region: HD_4; pfam13328 208964001336 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 208964001337 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 208964001338 homotetramer interface [polypeptide binding]; other site 208964001339 ligand binding site [chemical binding]; other site 208964001340 catalytic site [active] 208964001341 NAD binding site [chemical binding]; other site 208964001342 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 208964001343 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964001344 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964001345 N-terminal plug; other site 208964001346 ligand-binding site [chemical binding]; other site 208964001347 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 208964001348 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 208964001349 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 208964001350 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 208964001351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964001352 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 208964001353 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 208964001354 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 208964001355 active site 208964001356 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 208964001357 Na binding site [ion binding]; other site 208964001358 putative substrate binding site [chemical binding]; other site 208964001359 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 208964001360 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 208964001361 homodimer interface [polypeptide binding]; other site 208964001362 active site 208964001363 FMN binding site [chemical binding]; other site 208964001364 substrate binding site [chemical binding]; other site 208964001365 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 208964001366 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 208964001367 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 208964001368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208964001369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964001370 phenylhydantoinase; Validated; Region: PRK08323 208964001371 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 208964001372 tetramer interface [polypeptide binding]; other site 208964001373 active site 208964001374 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 208964001375 Na binding site [ion binding]; other site 208964001376 putative substrate binding site [chemical binding]; other site 208964001377 allantoate amidohydrolase; Reviewed; Region: PRK09290 208964001378 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 208964001379 active site 208964001380 metal binding site [ion binding]; metal-binding site 208964001381 dimer interface [polypeptide binding]; other site 208964001382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 208964001383 Transposase; Region: DEDD_Tnp_IS110; pfam01548 208964001384 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 208964001385 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 208964001386 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 208964001387 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 208964001388 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964001389 FAD binding site [chemical binding]; other site 208964001390 substrate binding pocket [chemical binding]; other site 208964001391 catalytic base [active] 208964001392 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964001393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964001394 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 208964001395 dimerization interface [polypeptide binding]; other site 208964001396 substrate binding pocket [chemical binding]; other site 208964001397 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 208964001398 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 208964001399 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 208964001400 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 208964001401 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 208964001402 dimer interface [polypeptide binding]; other site 208964001403 active site residues [active] 208964001404 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 208964001405 prohibitin homologues; Region: PHB; smart00244 208964001406 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 208964001407 trimer interface [polypeptide binding]; other site 208964001408 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964001409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964001410 substrate binding pocket [chemical binding]; other site 208964001411 membrane-bound complex binding site; other site 208964001412 hinge residues; other site 208964001413 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 208964001414 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 208964001415 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 208964001416 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 208964001417 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208964001418 ATP binding site [chemical binding]; other site 208964001419 Mg++ binding site [ion binding]; other site 208964001420 motif III; other site 208964001421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964001422 nucleotide binding region [chemical binding]; other site 208964001423 ATP-binding site [chemical binding]; other site 208964001424 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 208964001425 putative RNA binding site [nucleotide binding]; other site 208964001426 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208964001427 DNA-binding site [nucleotide binding]; DNA binding site 208964001428 RNA-binding motif; other site 208964001429 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 208964001430 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 208964001431 putative transporter; Provisional; Region: PRK10504 208964001432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964001433 putative substrate translocation pore; other site 208964001434 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 208964001435 Clp amino terminal domain; Region: Clp_N; pfam02861 208964001436 Clp amino terminal domain; Region: Clp_N; pfam02861 208964001437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964001438 Walker A motif; other site 208964001439 ATP binding site [chemical binding]; other site 208964001440 Walker B motif; other site 208964001441 arginine finger; other site 208964001442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964001443 Walker A motif; other site 208964001444 ATP binding site [chemical binding]; other site 208964001445 Walker B motif; other site 208964001446 arginine finger; other site 208964001447 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 208964001448 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 208964001449 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 208964001450 putative acyl-acceptor binding pocket; other site 208964001451 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 208964001452 DNA-binding response regulator CreB; Provisional; Region: PRK11083 208964001453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964001454 active site 208964001455 phosphorylation site [posttranslational modification] 208964001456 intermolecular recognition site; other site 208964001457 dimerization interface [polypeptide binding]; other site 208964001458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964001459 DNA binding site [nucleotide binding] 208964001460 sensory histidine kinase CreC; Provisional; Region: PRK11100 208964001461 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 208964001462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964001463 dimerization interface [polypeptide binding]; other site 208964001464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964001465 dimer interface [polypeptide binding]; other site 208964001466 phosphorylation site [posttranslational modification] 208964001467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964001468 ATP binding site [chemical binding]; other site 208964001469 Mg2+ binding site [ion binding]; other site 208964001470 G-X-G motif; other site 208964001471 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 208964001472 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 208964001473 putative glutathione S-transferase; Provisional; Region: PRK10357 208964001474 putative C-terminal domain interface [polypeptide binding]; other site 208964001475 putative GSH binding site (G-site) [chemical binding]; other site 208964001476 putative dimer interface [polypeptide binding]; other site 208964001477 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 208964001478 dimer interface [polypeptide binding]; other site 208964001479 N-terminal domain interface [polypeptide binding]; other site 208964001480 putative substrate binding pocket (H-site) [chemical binding]; other site 208964001481 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 208964001482 Protein phosphatase 2C; Region: PP2C_2; pfam13672 208964001483 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964001484 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 208964001485 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964001486 N-terminal plug; other site 208964001487 ligand-binding site [chemical binding]; other site 208964001488 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964001489 FecR protein; Region: FecR; pfam04773 208964001490 RNA polymerase sigma factor; Reviewed; Region: PRK12523 208964001491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964001492 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964001493 DNA binding residues [nucleotide binding] 208964001494 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964001495 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 208964001496 C-terminal domain interface [polypeptide binding]; other site 208964001497 GSH binding site (G-site) [chemical binding]; other site 208964001498 dimer interface [polypeptide binding]; other site 208964001499 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 208964001500 N-terminal domain interface [polypeptide binding]; other site 208964001501 dimer interface [polypeptide binding]; other site 208964001502 substrate binding pocket (H-site) [chemical binding]; other site 208964001503 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964001504 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 208964001505 CoenzymeA binding site [chemical binding]; other site 208964001506 subunit interaction site [polypeptide binding]; other site 208964001507 PHB binding site; other site 208964001508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964001509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964001510 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 208964001511 Na binding site [ion binding]; other site 208964001512 putative substrate binding site [chemical binding]; other site 208964001513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964001514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964001515 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 208964001516 putative substrate binding pocket [chemical binding]; other site 208964001517 dimerization interface [polypeptide binding]; other site 208964001518 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208964001519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964001520 Coenzyme A binding pocket [chemical binding]; other site 208964001521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964001522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964001523 LysR substrate binding domain; Region: LysR_substrate; pfam03466 208964001524 dimerization interface [polypeptide binding]; other site 208964001525 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 208964001526 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964001527 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 208964001528 active site 208964001529 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208964001530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964001531 Coenzyme A binding pocket [chemical binding]; other site 208964001532 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 208964001533 ACT domain; Region: ACT_6; pfam13740 208964001534 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 208964001535 Predicted permeases [General function prediction only]; Region: RarD; COG2962 208964001536 EamA-like transporter family; Region: EamA; pfam00892 208964001537 serine/threonine protein kinase; Provisional; Region: PRK11768 208964001538 Phosphotransferase enzyme family; Region: APH; pfam01636 208964001539 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 208964001540 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 208964001541 TOBE domain; Region: TOBE; cl01440 208964001542 TOBE domain; Region: TOBE; cl01440 208964001543 lipoprotein; Provisional; Region: PRK10759 208964001544 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 208964001545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964001546 active site 208964001547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964001548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964001549 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 208964001550 putative substrate binding pocket [chemical binding]; other site 208964001551 dimerization interface [polypeptide binding]; other site 208964001552 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 208964001553 putative active site [active] 208964001554 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208964001555 carboxyltransferase (CT) interaction site; other site 208964001556 biotinylation site [posttranslational modification]; other site 208964001557 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 208964001558 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208964001559 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964001560 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 208964001561 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 208964001562 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 208964001563 Fimbrial protein; Region: Fimbrial; pfam00419 208964001564 Fimbrial protein; Region: Fimbrial; pfam00419 208964001565 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 208964001566 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 208964001567 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 208964001568 biotin synthase; Provisional; Region: PRK15108 208964001569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964001570 FeS/SAM binding site; other site 208964001571 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 208964001572 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 208964001573 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 208964001574 substrate-cofactor binding pocket; other site 208964001575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964001576 catalytic residue [active] 208964001577 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 208964001578 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 208964001579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964001580 S-adenosylmethionine binding site [chemical binding]; other site 208964001581 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 208964001582 AAA domain; Region: AAA_26; pfam13500 208964001583 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 208964001584 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 208964001585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964001586 active site 208964001587 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 208964001588 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 208964001589 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 208964001590 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964001591 active site 208964001592 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 208964001593 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 208964001594 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 208964001595 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964001596 active site 208964001597 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 208964001598 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964001599 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964001600 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 208964001601 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 208964001602 structural tetrad; other site 208964001603 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 208964001604 active site 208964001605 SAM binding site [chemical binding]; other site 208964001606 homodimer interface [polypeptide binding]; other site 208964001607 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 208964001608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964001609 FeS/SAM binding site; other site 208964001610 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 208964001611 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964001612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964001613 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964001614 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964001615 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964001616 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964001617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964001618 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 208964001619 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964001620 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964001621 Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654 208964001622 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964001623 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964001624 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964001625 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 208964001626 MoxR-like ATPases [General function prediction only]; Region: COG0714 208964001627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964001628 Walker A motif; other site 208964001629 ATP binding site [chemical binding]; other site 208964001630 Walker B motif; other site 208964001631 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 208964001632 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 208964001633 Subunit I/III interface [polypeptide binding]; other site 208964001634 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964001635 Cytochrome c; Region: Cytochrom_C; pfam00034 208964001636 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 208964001637 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 208964001638 Low-spin heme binding site [chemical binding]; other site 208964001639 D-pathway; other site 208964001640 Putative water exit pathway; other site 208964001641 Binuclear center (active site) [active] 208964001642 K-pathway; other site 208964001643 Putative proton exit pathway; other site 208964001644 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 208964001645 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 208964001646 metal ion-dependent adhesion site (MIDAS); other site 208964001647 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 208964001648 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208964001649 ligand binding site [chemical binding]; other site 208964001650 flexible hinge region; other site 208964001651 putative switch regulator; other site 208964001652 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 208964001653 non-specific DNA interactions [nucleotide binding]; other site 208964001654 DNA binding site [nucleotide binding] 208964001655 sequence specific DNA binding site [nucleotide binding]; other site 208964001656 putative cAMP binding site [chemical binding]; other site 208964001657 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 208964001658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964001659 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964001660 dimerization interface [polypeptide binding]; other site 208964001661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 208964001662 MOSC domain; Region: MOSC; pfam03473 208964001663 3-alpha domain; Region: 3-alpha; pfam03475 208964001664 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964001665 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964001666 inhibitor-cofactor binding pocket; inhibition site 208964001667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964001668 catalytic residue [active] 208964001669 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 208964001670 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 208964001671 catalytic triad [active] 208964001672 PAS domain; Region: PAS_8; pfam13188 208964001673 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 208964001674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001675 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 208964001676 putative active site [active] 208964001677 heme pocket [chemical binding]; other site 208964001678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001679 putative active site [active] 208964001680 heme pocket [chemical binding]; other site 208964001681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964001682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964001683 DNA binding residues [nucleotide binding] 208964001684 dimerization interface [polypeptide binding]; other site 208964001685 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964001686 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964001687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964001688 non-specific DNA binding site [nucleotide binding]; other site 208964001689 salt bridge; other site 208964001690 sequence-specific DNA binding site [nucleotide binding]; other site 208964001691 Cupin domain; Region: Cupin_2; pfam07883 208964001692 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 208964001693 LemA family; Region: LemA; pfam04011 208964001694 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 208964001695 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 208964001696 EamA-like transporter family; Region: EamA; pfam00892 208964001697 Predicted membrane protein [Function unknown]; Region: COG3686 208964001698 Cytochrome c556 [Energy production and conversion]; Region: COG3909 208964001699 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 208964001700 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 208964001701 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964001702 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 208964001703 active site 208964001704 metal binding site [ion binding]; metal-binding site 208964001705 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 208964001706 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 208964001707 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 208964001708 FAD binding pocket [chemical binding]; other site 208964001709 FAD binding motif [chemical binding]; other site 208964001710 phosphate binding motif [ion binding]; other site 208964001711 beta-alpha-beta structure motif; other site 208964001712 NAD binding pocket [chemical binding]; other site 208964001713 S-adenosylmethionine synthetase; Validated; Region: PRK05250 208964001714 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 208964001715 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 208964001716 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 208964001717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964001718 putative DNA binding site [nucleotide binding]; other site 208964001719 dimerization interface [polypeptide binding]; other site 208964001720 putative Zn2+ binding site [ion binding]; other site 208964001721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964001722 S-adenosylmethionine binding site [chemical binding]; other site 208964001723 transketolase; Reviewed; Region: PRK12753 208964001724 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 208964001725 TPP-binding site [chemical binding]; other site 208964001726 dimer interface [polypeptide binding]; other site 208964001727 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 208964001728 PYR/PP interface [polypeptide binding]; other site 208964001729 dimer interface [polypeptide binding]; other site 208964001730 TPP binding site [chemical binding]; other site 208964001731 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 208964001732 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 208964001733 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 208964001734 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 208964001735 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 208964001736 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 208964001737 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 208964001738 substrate binding site [chemical binding]; other site 208964001739 hinge regions; other site 208964001740 ADP binding site [chemical binding]; other site 208964001741 catalytic site [active] 208964001742 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 208964001743 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 208964001744 intersubunit interface [polypeptide binding]; other site 208964001745 active site 208964001746 zinc binding site [ion binding]; other site 208964001747 Na+ binding site [ion binding]; other site 208964001748 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 208964001749 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964001750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964001751 S-adenosylmethionine binding site [chemical binding]; other site 208964001752 Zonular occludens toxin (Zot); Region: Zot; cl17485 208964001753 HI0933-like protein; Region: HI0933_like; pfam03486 208964001754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964001755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964001756 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 208964001757 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 208964001758 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 208964001759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964001760 motif II; other site 208964001761 Protein of unknown function (DUF805); Region: DUF805; pfam05656 208964001762 Cupin; Region: Cupin_6; pfam12852 208964001763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964001764 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964001765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964001766 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 208964001767 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 208964001768 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955 208964001769 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 208964001770 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 208964001771 Peptidase M60-like family; Region: M60-like; cl19940 208964001772 Nuclease-related domain; Region: NERD; pfam08378 208964001773 Fic family protein [Function unknown]; Region: COG3177 208964001774 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 208964001775 Fic/DOC family; Region: Fic; pfam02661 208964001776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964001777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964001778 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964001779 substrate binding pocket [chemical binding]; other site 208964001780 membrane-bound complex binding site; other site 208964001781 hinge residues; other site 208964001782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001783 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 208964001784 putative active site [active] 208964001785 heme pocket [chemical binding]; other site 208964001786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001787 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 208964001788 putative active site [active] 208964001789 heme pocket [chemical binding]; other site 208964001790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001791 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 208964001792 putative active site [active] 208964001793 heme pocket [chemical binding]; other site 208964001794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001795 putative active site [active] 208964001796 heme pocket [chemical binding]; other site 208964001797 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964001798 metal binding site [ion binding]; metal-binding site 208964001799 active site 208964001800 I-site; other site 208964001801 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964001802 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 208964001803 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 208964001804 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 208964001805 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 208964001806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964001807 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 208964001808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964001809 DNA binding residues [nucleotide binding] 208964001810 DNA primase; Validated; Region: dnaG; PRK05667 208964001811 CHC2 zinc finger; Region: zf-CHC2; pfam01807 208964001812 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 208964001813 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 208964001814 active site 208964001815 metal binding site [ion binding]; metal-binding site 208964001816 interdomain interaction site; other site 208964001817 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 208964001818 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 208964001819 Yqey-like protein; Region: YqeY; pfam09424 208964001820 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 208964001821 UGMP family protein; Validated; Region: PRK09604 208964001822 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 208964001823 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 208964001824 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 208964001825 homooctamer interface [polypeptide binding]; other site 208964001826 active site 208964001827 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 208964001828 catalytic center binding site [active] 208964001829 ATP binding site [chemical binding]; other site 208964001830 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 208964001831 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 208964001832 active site 208964001833 NTP binding site [chemical binding]; other site 208964001834 metal binding triad [ion binding]; metal-binding site 208964001835 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 208964001836 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964001837 Zn2+ binding site [ion binding]; other site 208964001838 Mg2+ binding site [ion binding]; other site 208964001839 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 208964001840 SpoVR family protein; Provisional; Region: PRK11767 208964001841 Uncharacterized conserved protein [Function unknown]; Region: COG2718 208964001842 PrkA family serine protein kinase; Provisional; Region: PRK15455 208964001843 PrkA AAA domain; Region: AAA_PrkA; pfam08298 208964001844 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 208964001845 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 208964001846 active site residue [active] 208964001847 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 208964001848 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 208964001849 active site 208964001850 metal binding site [ion binding]; metal-binding site 208964001851 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 208964001852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964001853 S-adenosylmethionine binding site [chemical binding]; other site 208964001854 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 208964001855 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 208964001856 SurA N-terminal domain; Region: SurA_N; pfam09312 208964001857 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 208964001858 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 208964001859 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 208964001860 OstA-like protein; Region: OstA; cl00844 208964001861 Organic solvent tolerance protein; Region: OstA_C; pfam04453 208964001862 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 208964001863 Phosphotransferase enzyme family; Region: APH; pfam01636 208964001864 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 208964001865 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 208964001866 Substrate binding site; other site 208964001867 metal-binding site 208964001868 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 208964001869 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 208964001870 putative metal binding site [ion binding]; other site 208964001871 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 208964001872 HSP70 interaction site [polypeptide binding]; other site 208964001873 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 208964001874 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964001875 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964001876 substrate binding pocket [chemical binding]; other site 208964001877 membrane-bound complex binding site; other site 208964001878 hinge residues; other site 208964001879 PAS domain; Region: PAS_9; pfam13426 208964001880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001881 putative active site [active] 208964001882 heme pocket [chemical binding]; other site 208964001883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964001884 PAS fold; Region: PAS_3; pfam08447 208964001885 putative active site [active] 208964001886 heme pocket [chemical binding]; other site 208964001887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 208964001888 Histidine kinase; Region: HisKA_3; pfam07730 208964001889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964001890 ATP binding site [chemical binding]; other site 208964001891 Mg2+ binding site [ion binding]; other site 208964001892 G-X-G motif; other site 208964001893 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964001894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964001895 active site 208964001896 phosphorylation site [posttranslational modification] 208964001897 intermolecular recognition site; other site 208964001898 dimerization interface [polypeptide binding]; other site 208964001899 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964001900 DNA binding residues [nucleotide binding] 208964001901 dimerization interface [polypeptide binding]; other site 208964001902 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208964001903 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 208964001904 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 208964001905 Walker A/P-loop; other site 208964001906 ATP binding site [chemical binding]; other site 208964001907 Q-loop/lid; other site 208964001908 ABC transporter signature motif; other site 208964001909 Walker B; other site 208964001910 D-loop; other site 208964001911 H-loop/switch region; other site 208964001912 Poxvirus L5 protein family; Region: Pox_L5; pfam04872 208964001913 TOBE domain; Region: TOBE_2; pfam08402 208964001914 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208964001915 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 208964001916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964001917 dimer interface [polypeptide binding]; other site 208964001918 conserved gate region; other site 208964001919 putative PBP binding loops; other site 208964001920 ABC-ATPase subunit interface; other site 208964001921 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964001922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964001923 dimer interface [polypeptide binding]; other site 208964001924 conserved gate region; other site 208964001925 putative PBP binding loops; other site 208964001926 ABC-ATPase subunit interface; other site 208964001927 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 208964001928 substrate binding site [chemical binding]; other site 208964001929 hexamer interface [polypeptide binding]; other site 208964001930 metal binding site [ion binding]; metal-binding site 208964001931 phosphoglycolate phosphatase; Provisional; Region: PRK13223 208964001932 phosphoglycolate phosphatase; Provisional; Region: PRK13222 208964001933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964001934 motif II; other site 208964001935 anthranilate synthase component I; Provisional; Region: PRK13565 208964001936 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 208964001937 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 208964001938 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 208964001939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964001940 non-specific DNA binding site [nucleotide binding]; other site 208964001941 Predicted transcriptional regulator [Transcription]; Region: COG2932 208964001942 salt bridge; other site 208964001943 sequence-specific DNA binding site [nucleotide binding]; other site 208964001944 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 208964001945 Catalytic site [active] 208964001946 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 208964001947 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 208964001948 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 208964001949 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 208964001950 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 208964001951 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 208964001952 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 208964001953 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 208964001954 phage contractile tail tube protein, P2 family; Region: tail_tube; TIGR01611 208964001955 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 208964001956 Mu-like prophage protein [General function prediction only]; Region: COG3941 208964001957 Predicted membrane protein [Function unknown]; Region: COG3918 208964001958 Phage protein U [General function prediction only]; Region: COG3499 208964001959 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 208964001960 Phage protein D [General function prediction only]; Region: COG3500 208964001961 Predicted chitinase [General function prediction only]; Region: COG3179 208964001962 catalytic residue [active] 208964001963 Phage-related minor tail protein [Function unknown]; Region: COG5281 208964001964 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 208964001965 Phage-related minor tail protein [Function unknown]; Region: COG5281 208964001966 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 208964001967 Phage-related protein [Function unknown]; Region: COG4718 208964001968 Phage-related protein [Function unknown]; Region: gp18; COG4672 208964001969 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 208964001970 MPN+ (JAMM) motif; other site 208964001971 Zinc-binding site [ion binding]; other site 208964001972 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 208964001973 NlpC/P60 family; Region: NLPC_P60; pfam00877 208964001974 Phage-related protein, tail component [Function unknown]; Region: COG4723 208964001975 Phage-related protein, tail component [Function unknown]; Region: COG4733 208964001976 Putative phage tail protein; Region: Phage-tail_3; pfam13550 208964001977 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 208964001978 Interdomain contacts; other site 208964001979 Cytokine receptor motif; other site 208964001980 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 208964001981 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 208964001982 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 208964001983 glutamine binding [chemical binding]; other site 208964001984 catalytic triad [active] 208964001985 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 208964001986 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 208964001987 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 208964001988 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 208964001989 active site 208964001990 ribulose/triose binding site [chemical binding]; other site 208964001991 phosphate binding site [ion binding]; other site 208964001992 substrate (anthranilate) binding pocket [chemical binding]; other site 208964001993 product (indole) binding pocket [chemical binding]; other site 208964001994 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 208964001995 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208964001996 ligand binding site [chemical binding]; other site 208964001997 flexible hinge region; other site 208964001998 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 208964001999 putative switch regulator; other site 208964002000 non-specific DNA interactions [nucleotide binding]; other site 208964002001 DNA binding site [nucleotide binding] 208964002002 sequence specific DNA binding site [nucleotide binding]; other site 208964002003 putative cAMP binding site [chemical binding]; other site 208964002004 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 208964002005 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 208964002006 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 208964002007 diiron binding motif [ion binding]; other site 208964002008 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 208964002009 nucleotide binding site/active site [active] 208964002010 HIT family signature motif; other site 208964002011 catalytic residue [active] 208964002012 Ycf46; Provisional; Region: ycf46; CHL00195 208964002013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964002014 Walker A motif; other site 208964002015 ATP binding site [chemical binding]; other site 208964002016 Walker B motif; other site 208964002017 arginine finger; other site 208964002018 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 208964002019 classical (c) SDRs; Region: SDR_c; cd05233 208964002020 NAD(P) binding site [chemical binding]; other site 208964002021 active site 208964002022 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 208964002023 Double zinc ribbon; Region: DZR; pfam12773 208964002024 Predicted membrane protein [Function unknown]; Region: COG3152 208964002025 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 208964002026 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 208964002027 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 208964002028 FMN binding site [chemical binding]; other site 208964002029 Predicted membrane protein [Function unknown]; Region: COG1981 208964002030 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 208964002031 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 208964002032 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 208964002033 Intraflagellar transport complex B, subunit 20; Region: IFT20; pfam14931 208964002034 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 208964002035 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 208964002036 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 208964002037 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 208964002038 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208964002039 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964002040 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 208964002041 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 208964002042 active site 208964002043 HIGH motif; other site 208964002044 dimer interface [polypeptide binding]; other site 208964002045 KMSKS motif; other site 208964002046 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 208964002047 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 208964002048 putative active site [active] 208964002049 putative PHP Thumb interface [polypeptide binding]; other site 208964002050 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 208964002051 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 208964002052 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 208964002053 generic binding surface II; other site 208964002054 generic binding surface I; other site 208964002055 DNA Polymerase Y-family; Region: PolY_like; cd03468 208964002056 active site 208964002057 DNA binding site [nucleotide binding] 208964002058 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 208964002059 Cell division inhibitor SulA; Region: SulA; cl01880 208964002060 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 208964002061 heme binding pocket [chemical binding]; other site 208964002062 heme ligand [chemical binding]; other site 208964002063 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964002064 TonB C terminal; Region: TonB_2; pfam13103 208964002065 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 208964002066 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964002067 DNA binding residues [nucleotide binding] 208964002068 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964002069 FecR protein; Region: FecR; pfam04773 208964002070 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 208964002071 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 208964002072 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 208964002073 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 208964002074 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 208964002075 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 208964002076 type II secretion system protein I; Region: gspI; TIGR01707 208964002077 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 208964002078 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 208964002079 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 208964002080 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 208964002081 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 208964002082 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 208964002083 GspL periplasmic domain; Region: GspL_C; pfam12693 208964002084 Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149 208964002085 type II secretion system protein D; Region: type_II_gspD; TIGR02517 208964002086 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964002087 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964002088 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964002089 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 208964002090 type II secretion system protein E; Region: type_II_gspE; TIGR02533 208964002091 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 208964002092 Walker A motif; other site 208964002093 ATP binding site [chemical binding]; other site 208964002094 Walker B motif; other site 208964002095 type II secretion system protein F; Region: GspF; TIGR02120 208964002096 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 208964002097 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 208964002098 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 208964002099 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 208964002100 haemagglutination activity domain; Region: Haemagg_act; pfam05860 208964002101 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 208964002102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 208964002103 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 208964002104 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 208964002105 Surface antigen; Region: Bac_surface_Ag; pfam01103 208964002106 Uncharacterized conserved protein [Function unknown]; Region: COG5306 208964002107 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 208964002108 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 208964002109 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 208964002110 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 208964002111 TonB C terminal; Region: TonB_2; pfam13103 208964002112 Outer membrane protein family (DUF1597); Region: DUF1597; cl19301 208964002113 hypothetical protein; Validated; Region: PRK09039 208964002114 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 208964002115 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 208964002116 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 208964002117 hypothetical protein; Provisional; Region: PRK10506 208964002118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964002119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964002120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964002121 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964002122 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 208964002123 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 208964002124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964002125 metabolite-proton symporter; Region: 2A0106; TIGR00883 208964002126 putative substrate translocation pore; other site 208964002127 amidase; Provisional; Region: PRK07042 208964002128 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 208964002129 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208964002130 active site 208964002131 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 208964002132 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 208964002133 trimer interface [polypeptide binding]; other site 208964002134 active site 208964002135 substrate binding site [chemical binding]; other site 208964002136 CoA binding site [chemical binding]; other site 208964002137 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 208964002138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964002139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964002140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964002141 dimerization interface [polypeptide binding]; other site 208964002142 Uncharacterized conserved protein [Function unknown]; Region: COG1359 208964002143 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 208964002144 dimer interface [polypeptide binding]; other site 208964002145 active site 208964002146 metal binding site [ion binding]; metal-binding site 208964002147 glutathione binding site [chemical binding]; other site 208964002148 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208964002149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964002150 Coenzyme A binding pocket [chemical binding]; other site 208964002151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3811 208964002152 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 208964002153 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 208964002154 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 208964002155 putative active site [active] 208964002156 putative NTP binding site [chemical binding]; other site 208964002157 putative nucleic acid binding site [nucleotide binding]; other site 208964002158 AAA domain; Region: AAA_23; pfam13476 208964002159 AAA domain; Region: AAA_21; pfam13304 208964002160 Walker A/P-loop; other site 208964002161 ATP binding site [chemical binding]; other site 208964002162 Q-loop/lid; other site 208964002163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 208964002164 ABC transporter signature motif; other site 208964002165 Walker B; other site 208964002166 D-loop; other site 208964002167 H-loop/switch region; other site 208964002168 Phage Coat protein B; Region: Phage_Coat_B; pfam05356 208964002169 hypothetical protein; Region: PHA01159 208964002170 Zonula occludens toxin [General function prediction only]; Region: Zot; COG4128 208964002171 Replication initiation factor; Region: Rep_trans; pfam02486 208964002172 integrase; Provisional; Region: int; PHA02601 208964002173 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 208964002174 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 208964002175 dimer interface [polypeptide binding]; other site 208964002176 active site 208964002177 catalytic residues [active] 208964002178 Int/Topo IB signature motif; other site 208964002179 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 208964002180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964002181 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 208964002182 hypothetical protein; Provisional; Region: PRK06132 208964002183 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 208964002184 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 208964002185 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208964002186 RNA binding surface [nucleotide binding]; other site 208964002187 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 208964002188 active site 208964002189 uracil binding [chemical binding]; other site 208964002190 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 208964002191 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 208964002192 Predicted membrane protein [Function unknown]; Region: COG3776 208964002193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964002194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964002195 LysR substrate binding domain; Region: LysR_substrate; pfam03466 208964002196 dimerization interface [polypeptide binding]; other site 208964002197 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 208964002198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208964002199 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 208964002200 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 208964002201 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208964002202 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 208964002203 NAD binding site [chemical binding]; other site 208964002204 substrate binding site [chemical binding]; other site 208964002205 putative active site [active] 208964002206 Ion channel; Region: Ion_trans_2; pfam07885 208964002207 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 208964002208 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 208964002209 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 208964002210 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 208964002211 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964002212 substrate binding site [chemical binding]; other site 208964002213 oxyanion hole (OAH) forming residues; other site 208964002214 trimer interface [polypeptide binding]; other site 208964002215 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 208964002216 enoyl-CoA hydratase; Provisional; Region: PRK09076 208964002217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964002218 substrate binding site [chemical binding]; other site 208964002219 oxyanion hole (OAH) forming residues; other site 208964002220 trimer interface [polypeptide binding]; other site 208964002221 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964002222 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 208964002223 substrate binding pocket [chemical binding]; other site 208964002224 FAD binding site [chemical binding]; other site 208964002225 catalytic base [active] 208964002226 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 208964002227 tetrameric interface [polypeptide binding]; other site 208964002228 NAD binding site [chemical binding]; other site 208964002229 catalytic residues [active] 208964002230 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 208964002231 VanW like protein; Region: VanW; pfam04294 208964002232 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 208964002233 ligand binding site [chemical binding]; other site 208964002234 active site 208964002235 UGI interface [polypeptide binding]; other site 208964002236 catalytic site [active] 208964002237 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 208964002238 Putative ammonia monooxygenase; Region: AmoA; pfam05145 208964002239 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 208964002240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 208964002241 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 208964002242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 208964002243 outer membrane porin, OprD family; Region: OprD; pfam03573 208964002244 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 208964002245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964002246 active site 208964002247 phosphorylation site [posttranslational modification] 208964002248 intermolecular recognition site; other site 208964002249 dimerization interface [polypeptide binding]; other site 208964002250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964002251 DNA binding site [nucleotide binding] 208964002252 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 208964002253 HAMP domain; Region: HAMP; pfam00672 208964002254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964002255 dimer interface [polypeptide binding]; other site 208964002256 phosphorylation site [posttranslational modification] 208964002257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964002258 ATP binding site [chemical binding]; other site 208964002259 G-X-G motif; other site 208964002260 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 208964002261 HDOD domain; Region: HDOD; pfam08668 208964002262 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 208964002263 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 208964002264 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 208964002265 Uncharacterized conserved protein [Function unknown]; Region: COG2938 208964002266 L-aspartate oxidase; Provisional; Region: PRK09077 208964002267 L-aspartate oxidase; Provisional; Region: PRK06175 208964002268 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 208964002269 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 208964002270 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964002271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964002272 DNA binding residues [nucleotide binding] 208964002273 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 208964002274 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 208964002275 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 208964002276 MucB/RseB family; Region: MucB_RseB; pfam03888 208964002277 Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086 208964002278 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 208964002279 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 208964002280 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 208964002281 protein binding site [polypeptide binding]; other site 208964002282 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 208964002283 protein binding site [polypeptide binding]; other site 208964002284 GTP-binding protein LepA; Provisional; Region: PRK05433 208964002285 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 208964002286 G1 box; other site 208964002287 putative GEF interaction site [polypeptide binding]; other site 208964002288 GTP/Mg2+ binding site [chemical binding]; other site 208964002289 Switch I region; other site 208964002290 G2 box; other site 208964002291 G3 box; other site 208964002292 Switch II region; other site 208964002293 G4 box; other site 208964002294 G5 box; other site 208964002295 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 208964002296 Elongation Factor G, domain II; Region: EFG_II; pfam14492 208964002297 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 208964002298 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 208964002299 signal peptidase I; Provisional; Region: PRK10861 208964002300 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 208964002301 Catalytic site [active] 208964002302 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 208964002303 ribonuclease III; Reviewed; Region: rnc; PRK00102 208964002304 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 208964002305 dimerization interface [polypeptide binding]; other site 208964002306 active site 208964002307 metal binding site [ion binding]; metal-binding site 208964002308 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 208964002309 dsRNA binding site [nucleotide binding]; other site 208964002310 GTPase Era; Reviewed; Region: era; PRK00089 208964002311 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 208964002312 G1 box; other site 208964002313 GTP/Mg2+ binding site [chemical binding]; other site 208964002314 Switch I region; other site 208964002315 G2 box; other site 208964002316 Switch II region; other site 208964002317 G3 box; other site 208964002318 G4 box; other site 208964002319 G5 box; other site 208964002320 KH domain; Region: KH_2; pfam07650 208964002321 Recombination protein O N terminal; Region: RecO_N; pfam11967 208964002322 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 208964002323 Recombination protein O C terminal; Region: RecO_C; pfam02565 208964002324 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 208964002325 active site 208964002326 hydrophilic channel; other site 208964002327 dimerization interface [polypeptide binding]; other site 208964002328 catalytic residues [active] 208964002329 active site lid [active] 208964002330 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 208964002331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964002332 S-adenosylmethionine binding site [chemical binding]; other site 208964002333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964002334 S-adenosylmethionine binding site [chemical binding]; other site 208964002335 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 208964002336 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964002337 membrane-bound complex binding site; other site 208964002338 hinge residues; other site 208964002339 Predicted secreted protein [Function unknown]; Region: COG5513 208964002340 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 208964002341 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 208964002342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964002343 Walker A motif; other site 208964002344 ATP binding site [chemical binding]; other site 208964002345 Walker B motif; other site 208964002346 arginine finger; other site 208964002347 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 208964002348 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964002349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964002350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964002351 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964002352 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964002353 N-terminal plug; other site 208964002354 ligand-binding site [chemical binding]; other site 208964002355 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 208964002356 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 208964002357 Proline dehydrogenase; Region: Pro_dh; pfam01619 208964002358 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 208964002359 Glutamate binding site [chemical binding]; other site 208964002360 NAD binding site [chemical binding]; other site 208964002361 catalytic residues [active] 208964002362 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 208964002363 Na binding site [ion binding]; other site 208964002364 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964002365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964002366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964002367 dimerization interface [polypeptide binding]; other site 208964002368 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 208964002369 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 208964002370 Predicted ATPase [General function prediction only]; Region: COG4637 208964002371 AAA domain; Region: AAA_23; pfam13476 208964002372 Walker A/P-loop; other site 208964002373 ATP binding site [chemical binding]; other site 208964002374 AAA domain; Region: AAA_21; pfam13304 208964002375 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 208964002376 Transglycosylase; Region: Transgly; cl19357 208964002377 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 208964002378 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 208964002379 Spore germination protein; Region: Spore_permease; cl17796 208964002380 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 208964002381 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964002382 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964002383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964002384 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 208964002385 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 208964002386 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 208964002387 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 208964002388 substrate binding site [chemical binding]; other site 208964002389 ligand binding site [chemical binding]; other site 208964002390 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 208964002391 substrate binding site [chemical binding]; other site 208964002392 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 208964002393 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 208964002394 dimer interface [polypeptide binding]; other site 208964002395 active site 208964002396 citrylCoA binding site [chemical binding]; other site 208964002397 oxalacetate/citrate binding site [chemical binding]; other site 208964002398 coenzyme A binding site [chemical binding]; other site 208964002399 catalytic triad [active] 208964002400 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 208964002401 tetramer interface [polypeptide binding]; other site 208964002402 active site 208964002403 Mg2+/Mn2+ binding site [ion binding]; other site 208964002404 Transcriptional regulators [Transcription]; Region: GntR; COG1802 208964002405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964002406 DNA-binding site [nucleotide binding]; DNA binding site 208964002407 FCD domain; Region: FCD; pfam07729 208964002408 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964002409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964002410 S-adenosylmethionine binding site [chemical binding]; other site 208964002411 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 208964002412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964002413 ATP binding site [chemical binding]; other site 208964002414 putative Mg++ binding site [ion binding]; other site 208964002415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964002416 nucleotide binding region [chemical binding]; other site 208964002417 ATP-binding site [chemical binding]; other site 208964002418 Protein of unknown function (DUF3649); Region: DUF3649; pfam12365 208964002419 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 208964002420 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 208964002421 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 208964002422 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 208964002423 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 208964002424 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208964002425 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 208964002426 active site 208964002427 catalytic tetrad [active] 208964002428 Predicted membrane protein [Function unknown]; Region: COG4270 208964002429 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 208964002430 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 208964002431 amidase catalytic site [active] 208964002432 Zn binding residues [ion binding]; other site 208964002433 substrate binding site [chemical binding]; other site 208964002434 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 208964002435 putative hydrophobic ligand binding site [chemical binding]; other site 208964002436 manganese transport protein MntH; Reviewed; Region: PRK00701 208964002437 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 208964002438 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 208964002439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964002440 motif II; other site 208964002441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964002442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964002443 putative substrate translocation pore; other site 208964002444 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 208964002445 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 208964002446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964002447 catalytic residue [active] 208964002448 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 208964002449 homotrimer interaction site [polypeptide binding]; other site 208964002450 putative active site [active] 208964002451 cell density-dependent motility repressor; Provisional; Region: PRK10082 208964002452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964002453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964002454 dimerization interface [polypeptide binding]; other site 208964002455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964002456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964002457 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 208964002458 putative dimerization interface [polypeptide binding]; other site 208964002459 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 208964002460 putative metal binding site [ion binding]; other site 208964002461 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 208964002462 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 208964002463 active site 208964002464 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 208964002465 Uncharacterized conserved protein [Function unknown]; Region: COG4104 208964002466 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 208964002467 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 208964002468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964002469 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964002470 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964002471 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 208964002472 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964002473 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964002474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964002475 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 208964002476 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964002477 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964002478 ligand binding site [chemical binding]; other site 208964002479 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 208964002480 putative acyl-acceptor binding pocket; other site 208964002481 phosphate acetyltransferase; Reviewed; Region: PRK05632 208964002482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 208964002483 DRTGG domain; Region: DRTGG; pfam07085 208964002484 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 208964002485 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 208964002486 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 208964002487 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 208964002488 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 208964002489 catalytic residues [active] 208964002490 dimer interface [polypeptide binding]; other site 208964002491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964002492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964002493 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 208964002494 putative active site [active] 208964002495 putative FMN binding site [chemical binding]; other site 208964002496 putative substrate binding site [chemical binding]; other site 208964002497 putative catalytic residue [active] 208964002498 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 208964002499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964002500 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 208964002501 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 208964002502 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 208964002503 Phosphoesterase family; Region: Phosphoesterase; pfam04185 208964002504 Domain of unknown function (DUF756); Region: DUF756; pfam05506 208964002505 Domain of unknown function (DUF756); Region: DUF756; pfam05506 208964002506 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 208964002507 putative sulfate transport protein CysZ; Validated; Region: PRK04949 208964002508 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 208964002509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964002510 dimerization interface [polypeptide binding]; other site 208964002511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964002512 PAS domain; Region: PAS_9; pfam13426 208964002513 putative active site [active] 208964002514 heme pocket [chemical binding]; other site 208964002515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964002516 metal binding site [ion binding]; metal-binding site 208964002517 active site 208964002518 I-site; other site 208964002519 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 208964002520 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 208964002521 dimer interface [polypeptide binding]; other site 208964002522 decamer (pentamer of dimers) interface [polypeptide binding]; other site 208964002523 catalytic triad [active] 208964002524 peroxidatic and resolving cysteines [active] 208964002525 thioredoxin reductase; Provisional; Region: PRK10262 208964002526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964002527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964002528 MAPEG family; Region: MAPEG; pfam01124 208964002529 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 208964002530 tetramer interface [polypeptide binding]; other site 208964002531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964002532 catalytic residue [active] 208964002533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 208964002534 Chitin binding domain; Region: Chitin_bind_3; pfam03067 208964002535 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 208964002536 fumarate hydratase; Provisional; Region: PRK12425 208964002537 Class II fumarases; Region: Fumarase_classII; cd01362 208964002538 active site 208964002539 tetramer interface [polypeptide binding]; other site 208964002540 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 208964002541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 208964002542 BolA-like protein; Region: BolA; pfam01722 208964002543 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 208964002544 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 208964002545 active site residue [active] 208964002546 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 208964002547 catalytic residues [active] 208964002548 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208964002549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208964002550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964002551 Walker A/P-loop; other site 208964002552 ATP binding site [chemical binding]; other site 208964002553 Q-loop/lid; other site 208964002554 ABC transporter signature motif; other site 208964002555 Walker B; other site 208964002556 D-loop; other site 208964002557 H-loop/switch region; other site 208964002558 PAS domain S-box; Region: sensory_box; TIGR00229 208964002559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964002560 putative active site [active] 208964002561 heme pocket [chemical binding]; other site 208964002562 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964002563 metal binding site [ion binding]; metal-binding site 208964002564 active site 208964002565 I-site; other site 208964002566 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964002567 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 208964002568 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 208964002569 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 208964002570 NAD(P) binding site [chemical binding]; other site 208964002571 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964002572 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964002573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964002574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964002575 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 208964002576 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 208964002577 dimer interface [polypeptide binding]; other site 208964002578 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 208964002579 active site 208964002580 Fe binding site [ion binding]; other site 208964002581 aromatic amino acid transporter; Provisional; Region: PRK10238 208964002582 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964002583 lysozyme inhibitor; Provisional; Region: PRK13792 208964002584 hypothetical protein; Provisional; Region: PRK09256 208964002585 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 208964002586 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 208964002587 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 208964002588 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 208964002589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964002590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964002591 homodimer interface [polypeptide binding]; other site 208964002592 catalytic residue [active] 208964002593 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 208964002594 aromatic arch; other site 208964002595 DCoH dimer interaction site [polypeptide binding]; other site 208964002596 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 208964002597 DCoH tetramer interaction site [polypeptide binding]; other site 208964002598 substrate binding site [chemical binding]; other site 208964002599 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 208964002600 cofactor binding site; other site 208964002601 metal binding site [ion binding]; metal-binding site 208964002602 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 208964002603 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 208964002604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964002605 putative active site [active] 208964002606 heme pocket [chemical binding]; other site 208964002607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964002608 Walker A motif; other site 208964002609 ATP binding site [chemical binding]; other site 208964002610 Walker B motif; other site 208964002611 arginine finger; other site 208964002612 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 208964002613 Fusaric acid resistance protein family; Region: FUSC; pfam04632 208964002614 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 208964002615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964002616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964002617 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964002618 putative effector binding pocket; other site 208964002619 dimerization interface [polypeptide binding]; other site 208964002620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964002621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964002622 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 208964002623 putative dimerization interface [polypeptide binding]; other site 208964002624 Uncharacterized conserved protein [Function unknown]; Region: COG3777 208964002625 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 208964002626 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 208964002627 active site 2 [active] 208964002628 active site 1 [active] 208964002629 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964002630 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964002631 active site 208964002632 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 208964002633 dimer interface [polypeptide binding]; other site 208964002634 metal binding site [ion binding]; metal-binding site 208964002635 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 208964002636 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 208964002637 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 208964002638 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 208964002639 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 208964002640 DctM-like transporters; Region: DctM; pfam06808 208964002641 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 208964002642 acetyl-CoA synthetase; Provisional; Region: PRK00174 208964002643 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 208964002644 active site 208964002645 CoA binding site [chemical binding]; other site 208964002646 acyl-activating enzyme (AAE) consensus motif; other site 208964002647 AMP binding site [chemical binding]; other site 208964002648 acetate binding site [chemical binding]; other site 208964002649 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 208964002650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964002651 substrate binding pocket [chemical binding]; other site 208964002652 membrane-bound complex binding site; other site 208964002653 hinge residues; other site 208964002654 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 208964002655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964002656 dimer interface [polypeptide binding]; other site 208964002657 conserved gate region; other site 208964002658 putative PBP binding loops; other site 208964002659 ABC-ATPase subunit interface; other site 208964002660 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 208964002661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964002662 dimer interface [polypeptide binding]; other site 208964002663 conserved gate region; other site 208964002664 putative PBP binding loops; other site 208964002665 ABC-ATPase subunit interface; other site 208964002666 Predicted deacylase [General function prediction only]; Region: COG3608 208964002667 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 208964002668 active site 208964002669 Zn binding site [ion binding]; other site 208964002670 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 208964002671 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208964002672 Walker A/P-loop; other site 208964002673 ATP binding site [chemical binding]; other site 208964002674 Q-loop/lid; other site 208964002675 ABC transporter signature motif; other site 208964002676 Walker B; other site 208964002677 D-loop; other site 208964002678 H-loop/switch region; other site 208964002679 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 208964002680 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 208964002681 conserved cys residue [active] 208964002682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964002683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964002684 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964002685 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964002686 inhibitor-cofactor binding pocket; inhibition site 208964002687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964002688 catalytic residue [active] 208964002689 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 208964002690 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 208964002691 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 208964002692 NAD(P) binding site [chemical binding]; other site 208964002693 catalytic residues [active] 208964002694 succinylarginine dihydrolase; Provisional; Region: PRK13281 208964002695 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 208964002696 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 208964002697 putative active site [active] 208964002698 Zn binding site [ion binding]; other site 208964002699 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 208964002700 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 208964002701 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964002702 catalytic residue [active] 208964002703 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 208964002704 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 208964002705 motif 1; other site 208964002706 active site 208964002707 motif 2; other site 208964002708 motif 3; other site 208964002709 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 208964002710 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 208964002711 DHHA1 domain; Region: DHHA1; pfam02272 208964002712 aspartate kinase; Reviewed; Region: PRK06635 208964002713 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 208964002714 putative nucleotide binding site [chemical binding]; other site 208964002715 putative catalytic residues [active] 208964002716 putative Mg ion binding site [ion binding]; other site 208964002717 putative aspartate binding site [chemical binding]; other site 208964002718 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 208964002719 putative allosteric regulatory site; other site 208964002720 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 208964002721 carbon storage regulator; Provisional; Region: PRK01712 208964002722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964002723 non-specific DNA binding site [nucleotide binding]; other site 208964002724 Predicted transcriptional regulator [Transcription]; Region: COG2932 208964002725 salt bridge; other site 208964002726 sequence-specific DNA binding site [nucleotide binding]; other site 208964002727 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 208964002728 Catalytic site [active] 208964002729 Protein of unknown function (DUF754); Region: DUF754; pfam05449 208964002730 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 208964002731 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 208964002732 MgtE intracellular N domain; Region: MgtE_N; smart00924 208964002733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 208964002734 Divalent cation transporter; Region: MgtE; cl00786 208964002735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 208964002736 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 208964002737 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 208964002738 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 208964002739 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 208964002740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964002741 FeS/SAM binding site; other site 208964002742 TRAM domain; Region: TRAM; pfam01938 208964002743 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 208964002744 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 208964002745 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 208964002746 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 208964002747 Predicted integral membrane protein [Function unknown]; Region: COG0392 208964002748 Uncharacterized conserved protein [Function unknown]; Region: COG2898 208964002749 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 208964002750 Replication protein A C terminal; Region: RPA_C; pfam08784 208964002751 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 208964002752 active site 208964002753 DNA polymerase IV; Validated; Region: PRK02406 208964002754 DNA binding site [nucleotide binding] 208964002755 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 208964002756 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 208964002757 Sulfatase; Region: Sulfatase; cl19157 208964002758 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 208964002759 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 208964002760 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 208964002761 putative ligand binding site [chemical binding]; other site 208964002762 putative NAD binding site [chemical binding]; other site 208964002763 catalytic site [active] 208964002764 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 208964002765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964002766 dimerization interface [polypeptide binding]; other site 208964002767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964002768 dimer interface [polypeptide binding]; other site 208964002769 phosphorylation site [posttranslational modification] 208964002770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964002771 ATP binding site [chemical binding]; other site 208964002772 Mg2+ binding site [ion binding]; other site 208964002773 G-X-G motif; other site 208964002774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964002775 active site 208964002776 phosphorylation site [posttranslational modification] 208964002777 intermolecular recognition site; other site 208964002778 dimerization interface [polypeptide binding]; other site 208964002779 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964002780 putative binding surface; other site 208964002781 active site 208964002782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964002783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964002784 active site 208964002785 phosphorylation site [posttranslational modification] 208964002786 intermolecular recognition site; other site 208964002787 dimerization interface [polypeptide binding]; other site 208964002788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964002789 DNA binding site [nucleotide binding] 208964002790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964002791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964002792 dimerization interface [polypeptide binding]; other site 208964002793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964002794 dimer interface [polypeptide binding]; other site 208964002795 phosphorylation site [posttranslational modification] 208964002796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964002797 ATP binding site [chemical binding]; other site 208964002798 Mg2+ binding site [ion binding]; other site 208964002799 G-X-G motif; other site 208964002800 outer membrane receptor FepA; Provisional; Region: PRK13528 208964002801 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964002802 N-terminal plug; other site 208964002803 ligand-binding site [chemical binding]; other site 208964002804 cysteine synthase; Region: PLN02565 208964002805 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 208964002806 dimer interface [polypeptide binding]; other site 208964002807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964002808 catalytic residue [active] 208964002809 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 208964002810 TRAM domain; Region: TRAM; pfam01938 208964002811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964002812 S-adenosylmethionine binding site [chemical binding]; other site 208964002813 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 208964002814 HD domain; Region: HD_4; pfam13328 208964002815 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 208964002816 synthetase active site [active] 208964002817 NTP binding site [chemical binding]; other site 208964002818 metal binding site [ion binding]; metal-binding site 208964002819 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 208964002820 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 208964002821 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 208964002822 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 208964002823 homodimer interface [polypeptide binding]; other site 208964002824 metal binding site [ion binding]; metal-binding site 208964002825 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 208964002826 homodimer interface [polypeptide binding]; other site 208964002827 active site 208964002828 putative chemical substrate binding site [chemical binding]; other site 208964002829 metal binding site [ion binding]; metal-binding site 208964002830 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 208964002831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 208964002832 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 208964002833 Transcriptional antiterminator [Transcription]; Region: Rof; COG4568 208964002834 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 208964002835 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 208964002836 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964002837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964002838 putative DNA binding site [nucleotide binding]; other site 208964002839 MarR family; Region: MarR_2; cl17246 208964002840 Early E1A protein; Region: Adeno_E1A; pfam02703 208964002841 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 208964002842 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 208964002843 active site 208964002844 substrate binding site [chemical binding]; other site 208964002845 cosubstrate binding site; other site 208964002846 catalytic site [active] 208964002847 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 208964002848 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 208964002849 dimerization interface [polypeptide binding]; other site 208964002850 putative ATP binding site [chemical binding]; other site 208964002851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 208964002852 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 208964002853 DNA replication initiation factor; Validated; Region: PRK05642 208964002854 Walker A motif; other site 208964002855 ATP binding site [chemical binding]; other site 208964002856 Walker B motif; other site 208964002857 arginine finger; other site 208964002858 Predicted membrane protein [Function unknown]; Region: COG3308 208964002859 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 208964002860 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 208964002861 catalytic residues [active] 208964002862 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 208964002863 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 208964002864 catalytic residues [active] 208964002865 acylphosphatase; Provisional; Region: PRK14442 208964002866 prolyl-tRNA synthetase; Provisional; Region: PRK09194 208964002867 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 208964002868 dimer interface [polypeptide binding]; other site 208964002869 motif 1; other site 208964002870 active site 208964002871 motif 2; other site 208964002872 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 208964002873 putative deacylase active site [active] 208964002874 motif 3; other site 208964002875 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 208964002876 anticodon binding site; other site 208964002877 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964002878 CoenzymeA binding site [chemical binding]; other site 208964002879 subunit interaction site [polypeptide binding]; other site 208964002880 PHB binding site; other site 208964002881 outer membrane porin, OprD family; Region: OprD; pfam03573 208964002882 HIT domain; Region: HIT; pfam01230 208964002883 nucleotide binding site/active site [active] 208964002884 HIT family signature motif; other site 208964002885 catalytic residue [active] 208964002886 hypothetical protein; Provisional; Region: PRK00295 208964002887 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208964002888 DNA-binding site [nucleotide binding]; DNA binding site 208964002889 RNA-binding motif; other site 208964002890 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 208964002891 Ferritin-like domain; Region: Ferritin; pfam00210 208964002892 dimerization interface [polypeptide binding]; other site 208964002893 DPS ferroxidase diiron center [ion binding]; other site 208964002894 ion pore; other site 208964002895 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 208964002896 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 208964002897 dimer interface [polypeptide binding]; other site 208964002898 anticodon binding site; other site 208964002899 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 208964002900 homodimer interface [polypeptide binding]; other site 208964002901 motif 1; other site 208964002902 active site 208964002903 motif 2; other site 208964002904 GAD domain; Region: GAD; pfam02938 208964002905 motif 3; other site 208964002906 hypothetical protein; Validated; Region: PRK00110 208964002907 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 208964002908 active site 208964002909 putative DNA-binding cleft [nucleotide binding]; other site 208964002910 dimer interface [polypeptide binding]; other site 208964002911 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 208964002912 RuvA N terminal domain; Region: RuvA_N; pfam01330 208964002913 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 208964002914 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 208964002915 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 208964002916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964002917 Walker A motif; other site 208964002918 ATP binding site [chemical binding]; other site 208964002919 Walker B motif; other site 208964002920 arginine finger; other site 208964002921 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 208964002922 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208964002923 active site 208964002924 TolQ protein; Region: tolQ; TIGR02796 208964002925 TolR protein; Region: tolR; TIGR02801 208964002926 TolA protein; Region: tolA_full; TIGR02794 208964002927 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 208964002928 translocation protein TolB; Provisional; Region: tolB; PRK00178 208964002929 TolB amino-terminal domain; Region: TolB_N; pfam04052 208964002930 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 208964002931 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 208964002932 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 208964002933 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964002934 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964002935 ligand binding site [chemical binding]; other site 208964002936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 208964002937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964002938 binding surface 208964002939 TPR motif; other site 208964002940 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 208964002941 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 208964002942 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964002943 FeS/SAM binding site; other site 208964002944 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 208964002945 Ligand Binding Site [chemical binding]; other site 208964002946 putative transposase OrfB; Reviewed; Region: PHA02517 208964002947 HTH-like domain; Region: HTH_21; pfam13276 208964002948 Integrase core domain; Region: rve; pfam00665 208964002949 Integrase core domain; Region: rve_3; pfam13683 208964002950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 208964002951 Transposase; Region: HTH_Tnp_1; pfam01527 208964002952 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 208964002953 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 208964002954 catalytic residues [active] 208964002955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 208964002956 Transposase; Region: HTH_Tnp_1; pfam01527 208964002957 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 208964002958 Colicin-like bacteriocin tRNase domain; Region: Cloacin; pfam03515 208964002959 Colicin pore forming domain; Region: Colicin; pfam01024 208964002960 Transposase; Region: HTH_Tnp_1; pfam01527 208964002961 putative transposase OrfB; Reviewed; Region: PHA02517 208964002962 HTH-like domain; Region: HTH_21; pfam13276 208964002963 Integrase core domain; Region: rve; pfam00665 208964002964 Integrase core domain; Region: rve_3; pfam13683 208964002965 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208964002966 active site 208964002967 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 208964002968 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 208964002969 nudix motif; other site 208964002970 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 208964002971 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 208964002972 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 208964002973 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 208964002974 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 208964002975 PapC N-terminal domain; Region: PapC_N; pfam13954 208964002976 Outer membrane usher protein; Region: Usher; pfam00577 208964002977 PapC C-terminal domain; Region: PapC_C; pfam13953 208964002978 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 208964002979 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 208964002980 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 208964002981 DNA binding site [nucleotide binding] 208964002982 active site 208964002983 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 208964002984 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 208964002985 dimer interface [polypeptide binding]; other site 208964002986 acyl-activating enzyme (AAE) consensus motif; other site 208964002987 putative active site [active] 208964002988 putative AMP binding site [chemical binding]; other site 208964002989 putative CoA binding site [chemical binding]; other site 208964002990 chemical substrate binding site [chemical binding]; other site 208964002991 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 208964002992 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 208964002993 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 208964002994 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 208964002995 active site 208964002996 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 208964002997 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 208964002998 dimer interface [polypeptide binding]; other site 208964002999 active site 208964003000 CoA binding pocket [chemical binding]; other site 208964003001 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 208964003002 anthranilate synthase component I; Provisional; Region: PRK13564 208964003003 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 208964003004 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 208964003005 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 208964003006 Glutamine amidotransferase class-I; Region: GATase; pfam00117 208964003007 glutamine binding [chemical binding]; other site 208964003008 catalytic triad [active] 208964003009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964003012 dimerization interface [polypeptide binding]; other site 208964003013 quinolinate synthetase; Provisional; Region: PRK09375 208964003014 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 208964003015 Peptidase family M48; Region: Peptidase_M48; cl12018 208964003016 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 208964003017 CPxP motif; other site 208964003018 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 208964003019 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 208964003020 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 208964003021 catalytic triad [active] 208964003022 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 208964003023 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 208964003024 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 208964003025 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 208964003026 dimer interface [polypeptide binding]; other site 208964003027 active site 208964003028 catalytic residue [active] 208964003029 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 208964003030 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 208964003031 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 208964003032 ATP binding site [chemical binding]; other site 208964003033 active site 208964003034 substrate binding site [chemical binding]; other site 208964003035 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 208964003036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 208964003037 active site 208964003038 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 208964003039 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208964003040 Bacterial transcriptional regulator; Region: IclR; pfam01614 208964003041 thiolase; Provisional; Region: PRK06158 208964003042 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 208964003043 active site 208964003044 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 208964003045 CoA binding domain; Region: CoA_binding_2; pfam13380 208964003046 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 208964003047 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 208964003048 enoyl-CoA hydratase; Region: PLN02864 208964003049 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 208964003050 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 208964003051 dimer interaction site [polypeptide binding]; other site 208964003052 substrate-binding tunnel; other site 208964003053 active site 208964003054 catalytic site [active] 208964003055 substrate binding site [chemical binding]; other site 208964003056 benzoate transport; Region: 2A0115; TIGR00895 208964003057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003058 putative substrate translocation pore; other site 208964003059 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964003060 CoenzymeA binding site [chemical binding]; other site 208964003061 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 208964003062 subunit interaction site [polypeptide binding]; other site 208964003063 PHB binding site; other site 208964003064 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 208964003065 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 208964003066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964003067 active site 208964003068 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 208964003069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964003070 substrate binding site [chemical binding]; other site 208964003071 oxyanion hole (OAH) forming residues; other site 208964003072 trimer interface [polypeptide binding]; other site 208964003073 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 208964003074 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964003075 active site 208964003076 short chain dehydrogenase; Provisional; Region: PRK07791 208964003077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964003078 NAD(P) binding site [chemical binding]; other site 208964003079 active site 208964003080 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 208964003081 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 208964003082 FMN binding site [chemical binding]; other site 208964003083 substrate binding site [chemical binding]; other site 208964003084 putative catalytic residue [active] 208964003085 outer membrane porin, OprD family; Region: OprD; pfam03573 208964003086 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 208964003087 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 208964003088 tetrameric interface [polypeptide binding]; other site 208964003089 NAD binding site [chemical binding]; other site 208964003090 catalytic residues [active] 208964003091 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964003092 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964003093 RES domain; Region: RES; smart00953 208964003094 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 208964003095 RmuC family; Region: RmuC; pfam02646 208964003096 Penicillin amidase; Region: Penicil_amidase; pfam01804 208964003097 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 208964003098 active site 208964003099 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 208964003100 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 208964003101 C-terminal domain interface [polypeptide binding]; other site 208964003102 GSH binding site (G-site) [chemical binding]; other site 208964003103 dimer interface [polypeptide binding]; other site 208964003104 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 208964003105 N-terminal domain interface [polypeptide binding]; other site 208964003106 putative dimer interface [polypeptide binding]; other site 208964003107 active site 208964003108 SEC-C motif; Region: SEC-C; cl19389 208964003109 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 208964003110 Predicted membrane protein [Function unknown]; Region: COG2860 208964003111 UPF0126 domain; Region: UPF0126; pfam03458 208964003112 UPF0126 domain; Region: UPF0126; pfam03458 208964003113 hypothetical protein; Provisional; Region: PRK00183 208964003114 SEC-C motif; Region: SEC-C; cl19389 208964003115 SEC-C motif; Region: SEC-C; cl19389 208964003116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964003117 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964003118 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964003119 ligand binding site [chemical binding]; other site 208964003120 Predicted membrane protein [Function unknown]; Region: COG3776 208964003121 Predicted integral membrane protein [Function unknown]; Region: COG5615 208964003122 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 208964003123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 208964003124 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 208964003125 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 208964003126 Beta-lactamase; Region: Beta-lactamase; pfam00144 208964003127 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964003128 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964003129 ligand binding site [chemical binding]; other site 208964003130 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 208964003131 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 208964003132 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 208964003133 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 208964003134 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 208964003135 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 208964003136 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 208964003137 fructuronate transporter; Provisional; Region: PRK10034; cl15264 208964003138 glycerate kinase; Region: TIGR00045 208964003139 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 208964003140 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 208964003141 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 208964003142 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 208964003143 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 208964003144 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 208964003145 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 208964003146 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 208964003147 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 208964003148 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 208964003149 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 208964003150 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964003151 EamA-like transporter family; Region: EamA; pfam00892 208964003152 EamA-like transporter family; Region: EamA; pfam00892 208964003153 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 208964003154 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964003155 catalytic residue [active] 208964003156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208964003157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964003158 Coenzyme A binding pocket [chemical binding]; other site 208964003159 Predicted membrane protein [Function unknown]; Region: COG3650 208964003160 Uncharacterized conserved protein [Function unknown]; Region: COG3189 208964003161 short chain dehydrogenase; Region: adh_short; pfam00106 208964003162 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 208964003163 putative NAD(P) binding site [chemical binding]; other site 208964003164 homodimer interface [polypeptide binding]; other site 208964003165 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003167 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964003168 putative effector binding pocket; other site 208964003169 dimerization interface [polypeptide binding]; other site 208964003170 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 208964003171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964003172 ATP binding site [chemical binding]; other site 208964003173 Mg2+ binding site [ion binding]; other site 208964003174 G-X-G motif; other site 208964003175 Tetratricopeptide repeat; Region: TPR_20; pfam14561 208964003176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964003177 TPR motif; other site 208964003178 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 208964003179 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 208964003180 Walker A/P-loop; other site 208964003181 ATP binding site [chemical binding]; other site 208964003182 Q-loop/lid; other site 208964003183 ABC transporter signature motif; other site 208964003184 Walker B; other site 208964003185 D-loop; other site 208964003186 H-loop/switch region; other site 208964003187 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 208964003188 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 208964003189 Walker A/P-loop; other site 208964003190 ATP binding site [chemical binding]; other site 208964003191 Q-loop/lid; other site 208964003192 ABC transporter signature motif; other site 208964003193 Walker B; other site 208964003194 D-loop; other site 208964003195 H-loop/switch region; other site 208964003196 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 208964003197 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 208964003198 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 208964003199 TM-ABC transporter signature motif; other site 208964003200 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 208964003201 TM-ABC transporter signature motif; other site 208964003202 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 208964003203 dimerization interface [polypeptide binding]; other site 208964003204 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 208964003205 ligand binding site [chemical binding]; other site 208964003206 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 208964003207 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 208964003208 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 208964003209 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 208964003210 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208964003211 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208964003212 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 208964003213 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 208964003214 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 208964003215 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 208964003216 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208964003217 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 208964003218 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208964003219 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 208964003220 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208964003221 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 208964003222 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 208964003223 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208964003224 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208964003225 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 208964003226 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 208964003227 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 208964003228 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 208964003229 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 208964003230 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 208964003231 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208964003232 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 208964003233 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 208964003234 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 208964003235 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964003236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964003237 S-adenosylmethionine binding site [chemical binding]; other site 208964003238 O-methyltransferase; Region: Methyltransf_2; pfam00891 208964003239 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 208964003240 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 208964003241 Predicted sugar nucleotidyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1213 208964003242 active site 208964003243 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 208964003244 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 208964003245 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 208964003246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 208964003247 active site 208964003248 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 208964003249 flagellin; Reviewed; Region: PRK08869 208964003250 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 208964003251 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 208964003252 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 208964003253 Uncharacterized flagellar protein FlaG [Cell motility and secretion]; Region: FlaG; COG1334 208964003254 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 208964003255 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 208964003256 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 208964003257 flagellar protein FliS; Validated; Region: fliS; PRK05685 208964003258 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964003259 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 208964003260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964003261 Walker A motif; other site 208964003262 ATP binding site [chemical binding]; other site 208964003263 Walker B motif; other site 208964003264 arginine finger; other site 208964003265 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964003266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964003267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964003268 putative active site [active] 208964003269 heme pocket [chemical binding]; other site 208964003270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964003271 dimer interface [polypeptide binding]; other site 208964003272 phosphorylation site [posttranslational modification] 208964003273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964003274 ATP binding site [chemical binding]; other site 208964003275 Mg2+ binding site [ion binding]; other site 208964003276 G-X-G motif; other site 208964003277 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964003278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964003279 active site 208964003280 phosphorylation site [posttranslational modification] 208964003281 intermolecular recognition site; other site 208964003282 dimerization interface [polypeptide binding]; other site 208964003283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964003284 Walker A motif; other site 208964003285 ATP binding site [chemical binding]; other site 208964003286 Walker B motif; other site 208964003287 arginine finger; other site 208964003288 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964003289 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 208964003290 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 208964003291 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 208964003292 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 208964003293 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 208964003294 FliG N-terminal domain; Region: FliG_N; pfam14842 208964003295 FliG middle domain; Region: FliG_M; pfam14841 208964003296 FliG C-terminal domain; Region: FliG_C; pfam01706 208964003297 flagellar assembly protein H; Validated; Region: fliH; PRK05687 208964003298 Flagellar assembly protein FliH; Region: FliH; pfam02108 208964003299 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 208964003300 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 208964003301 Walker A motif/ATP binding site; other site 208964003302 Walker B motif; other site 208964003303 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 208964003304 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 208964003305 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 208964003306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964003307 metal binding site [ion binding]; metal-binding site 208964003308 active site 208964003309 I-site; other site 208964003310 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 208964003311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003312 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964003313 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964003314 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 208964003315 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208964003316 RNA binding surface [nucleotide binding]; other site 208964003317 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 208964003318 active site 208964003319 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 208964003320 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 208964003321 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 208964003322 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 208964003323 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208964003324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964003325 Walker A/P-loop; other site 208964003326 ATP binding site [chemical binding]; other site 208964003327 Q-loop/lid; other site 208964003328 ABC transporter signature motif; other site 208964003329 Walker B; other site 208964003330 D-loop; other site 208964003331 H-loop/switch region; other site 208964003332 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 208964003333 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 208964003334 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 208964003335 Sulfatase; Region: Sulfatase; pfam00884 208964003336 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 208964003337 S1 domain; Region: S1_2; pfam13509 208964003338 S1 domain; Region: S1_2; pfam13509 208964003339 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964003340 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964003341 ligand binding site [chemical binding]; other site 208964003342 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 208964003343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964003344 dimerization interface [polypeptide binding]; other site 208964003345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964003346 metal binding site [ion binding]; metal-binding site 208964003347 active site 208964003348 I-site; other site 208964003349 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 208964003350 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 208964003351 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 208964003352 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964003353 Zn2+ binding site [ion binding]; other site 208964003354 Mg2+ binding site [ion binding]; other site 208964003355 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 208964003356 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 208964003357 NAD+ binding site [chemical binding]; other site 208964003358 substrate binding site [chemical binding]; other site 208964003359 Zn binding site [ion binding]; other site 208964003360 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 208964003361 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208964003362 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 208964003363 active site 208964003364 catalytic tetrad [active] 208964003365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003367 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 208964003368 putative effector binding pocket; other site 208964003369 putative dimerization interface [polypeptide binding]; other site 208964003370 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 208964003371 dimer interface [polypeptide binding]; other site 208964003372 Mn binding site [ion binding]; other site 208964003373 K binding site [ion binding]; other site 208964003374 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 208964003375 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 208964003376 Ligand binding site; other site 208964003377 H+ Antiporter protein; Region: 2A0121; TIGR00900 208964003378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003379 putative substrate translocation pore; other site 208964003380 Protein of unknown function (DUF445); Region: DUF445; pfam04286 208964003381 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 208964003382 chaperone protein HchA; Provisional; Region: PRK04155 208964003383 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 208964003384 conserved cys residue [active] 208964003385 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 208964003386 Autoinducer binding domain; Region: Autoind_bind; pfam03472 208964003387 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964003388 DNA binding residues [nucleotide binding] 208964003389 dimerization interface [polypeptide binding]; other site 208964003390 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 208964003391 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 208964003392 NAD(P) binding site [chemical binding]; other site 208964003393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003395 LysR substrate binding domain; Region: LysR_substrate; pfam03466 208964003396 dimerization interface [polypeptide binding]; other site 208964003397 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 208964003398 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 208964003399 hypothetical protein; Provisional; Region: PRK11171 208964003400 Cupin domain; Region: Cupin_2; pfam07883 208964003401 Cupin domain; Region: Cupin_2; cl17218 208964003402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964003405 dimerization interface [polypeptide binding]; other site 208964003406 transcriptional regulator protein; Region: phnR; TIGR03337 208964003407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964003408 DNA-binding site [nucleotide binding]; DNA binding site 208964003409 UTRA domain; Region: UTRA; pfam07702 208964003410 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 208964003411 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 208964003412 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 208964003413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003414 putative substrate translocation pore; other site 208964003415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964003418 dimerization interface [polypeptide binding]; other site 208964003419 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 208964003420 putative active site [active] 208964003421 metal binding site [ion binding]; metal-binding site 208964003422 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964003423 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 208964003424 Exotoxin A binding; Region: Exotox-A_bind; pfam09101 208964003425 Exotoxin A, targeting; Region: Exotox-A_target; pfam09102 208964003426 Mono-ADP-ribosylating toxins catalyze the transfer of ADP_ribose from NAD+ to eukaryotic Elongation Factor 2, halting protein synthesis. A single molecule of delivered toxin is sufficient to kill a cell. These toxins share mono-ADP-ribosylating activity...; Region: Dipth_tox_like; cd01436 208964003427 nad+ binding pocket [chemical binding]; other site 208964003428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 208964003429 Colicin-like bacteriocin tRNase domain; Region: Cloacin; pfam03515 208964003430 S-type Pyocin; Region: Pyocin_S; pfam06958 208964003431 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 208964003432 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 208964003433 active site 208964003434 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 208964003435 Prophage antirepressor [Transcription]; Region: COG3617 208964003436 BRO family, N-terminal domain; Region: Bro-N; smart01040 208964003437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 208964003438 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 208964003439 dimer interface [polypeptide binding]; other site 208964003440 putative radical transfer pathway; other site 208964003441 diiron center [ion binding]; other site 208964003442 tyrosyl radical; other site 208964003443 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 208964003444 ATP cone domain; Region: ATP-cone; pfam03477 208964003445 ATP cone domain; Region: ATP-cone; pfam03477 208964003446 Class I ribonucleotide reductase; Region: RNR_I; cd01679 208964003447 active site 208964003448 dimer interface [polypeptide binding]; other site 208964003449 catalytic residues [active] 208964003450 effector binding site; other site 208964003451 R2 peptide binding site; other site 208964003452 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 208964003453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964003454 active site 208964003455 phosphorylation site [posttranslational modification] 208964003456 intermolecular recognition site; other site 208964003457 dimerization interface [polypeptide binding]; other site 208964003458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964003459 DNA binding site [nucleotide binding] 208964003460 sensor protein RstB; Provisional; Region: PRK10604 208964003461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964003462 dimerization interface [polypeptide binding]; other site 208964003463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964003464 dimer interface [polypeptide binding]; other site 208964003465 phosphorylation site [posttranslational modification] 208964003466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964003467 ATP binding site [chemical binding]; other site 208964003468 Mg2+ binding site [ion binding]; other site 208964003469 G-X-G motif; other site 208964003470 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208964003471 DNA-binding site [nucleotide binding]; DNA binding site 208964003472 RNA-binding motif; other site 208964003473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964003474 S-adenosylmethionine binding site [chemical binding]; other site 208964003475 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 208964003476 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 208964003477 metal binding site [ion binding]; metal-binding site 208964003478 dimer interface [polypeptide binding]; other site 208964003479 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 208964003480 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 208964003481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 208964003482 active site 208964003483 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 208964003484 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 208964003485 putative ATP binding site [chemical binding]; other site 208964003486 putative substrate interface [chemical binding]; other site 208964003487 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 208964003488 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 208964003489 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 208964003490 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964003491 Alginate lyase; Region: Alginate_lyase2; pfam08787 208964003492 Lipoxygenase; Region: Lipoxygenase; pfam00305 208964003493 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 208964003494 lytic murein transglycosylase; Region: MltB_2; TIGR02283 208964003495 Transglycosylase SLT domain; Region: SLT_2; pfam13406 208964003496 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964003497 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964003498 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 208964003499 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 208964003500 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 208964003501 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 208964003502 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 208964003503 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 208964003504 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 208964003505 [4Fe-4S] binding site [ion binding]; other site 208964003506 molybdopterin cofactor binding site; other site 208964003507 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 208964003508 molybdopterin cofactor binding site; other site 208964003509 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 208964003510 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 208964003511 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 208964003512 Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459 208964003513 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 208964003514 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 208964003515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964003516 active site 208964003517 phosphorylation site [posttranslational modification] 208964003518 intermolecular recognition site; other site 208964003519 dimerization interface [polypeptide binding]; other site 208964003520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964003521 DNA binding site [nucleotide binding] 208964003522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964003523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964003524 dimer interface [polypeptide binding]; other site 208964003525 phosphorylation site [posttranslational modification] 208964003526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964003527 ATP binding site [chemical binding]; other site 208964003528 G-X-G motif; other site 208964003529 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 208964003530 putative diguanylate cyclase; Provisional; Region: PRK09776 208964003531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964003532 putative active site [active] 208964003533 heme pocket [chemical binding]; other site 208964003534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964003535 putative active site [active] 208964003536 heme pocket [chemical binding]; other site 208964003537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964003538 putative active site [active] 208964003539 heme pocket [chemical binding]; other site 208964003540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964003541 metal binding site [ion binding]; metal-binding site 208964003542 active site 208964003543 I-site; other site 208964003544 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964003545 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964003546 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964003547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964003548 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 208964003549 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964003550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003551 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 208964003552 dimerization interface [polypeptide binding]; other site 208964003553 substrate binding pocket [chemical binding]; other site 208964003554 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964003555 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 208964003556 C-terminal domain interface [polypeptide binding]; other site 208964003557 GSH binding site (G-site) [chemical binding]; other site 208964003558 dimer interface [polypeptide binding]; other site 208964003559 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 208964003560 dimer interface [polypeptide binding]; other site 208964003561 N-terminal domain interface [polypeptide binding]; other site 208964003562 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 208964003563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964003564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964003565 active site 208964003566 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 208964003567 hypothetical protein; Provisional; Region: PRK04860 208964003568 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 208964003569 DNA-J related protein; Region: DNAJ_related; pfam12339 208964003570 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 208964003571 HSP70 interaction site [polypeptide binding]; other site 208964003572 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 208964003573 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 208964003574 Ligand Binding Site [chemical binding]; other site 208964003575 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 208964003576 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 208964003577 Spore germination protein; Region: Spore_permease; cl17796 208964003578 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 208964003579 PAS fold; Region: PAS_4; pfam08448 208964003580 photoactive yellow protein; Region: photo_yellow; TIGR02373 208964003581 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 208964003582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964003583 Walker A motif; other site 208964003584 ATP binding site [chemical binding]; other site 208964003585 Walker B motif; other site 208964003586 arginine finger; other site 208964003587 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964003588 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 208964003589 NAD+ binding site [chemical binding]; other site 208964003590 substrate binding site [chemical binding]; other site 208964003591 Zn binding site [ion binding]; other site 208964003592 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 208964003593 NlpC/P60 family; Region: NLPC_P60; pfam00877 208964003594 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 208964003595 NlpC/P60 family; Region: NLPC_P60; pfam00877 208964003596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964003597 S-adenosylmethionine binding site [chemical binding]; other site 208964003598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003600 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964003601 putative effector binding pocket; other site 208964003602 dimerization interface [polypeptide binding]; other site 208964003603 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 208964003604 catalytic triad [active] 208964003605 dimer interface [polypeptide binding]; other site 208964003606 conserved cis-peptide bond; other site 208964003607 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 208964003608 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 208964003609 Pirin-related protein [General function prediction only]; Region: COG1741 208964003610 Pirin; Region: Pirin; pfam02678 208964003611 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 208964003612 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 208964003613 putative hydrophobic ligand binding site [chemical binding]; other site 208964003614 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 208964003615 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 208964003616 TrkA-N domain; Region: TrkA_N; pfam02254 208964003617 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 208964003618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 208964003619 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 208964003620 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 208964003621 active site residue [active] 208964003622 Pirin-related protein [General function prediction only]; Region: COG1741 208964003623 Pirin; Region: Pirin; pfam02678 208964003624 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 208964003625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964003626 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964003627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964003629 putative substrate translocation pore; other site 208964003630 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 208964003631 substrate binding pocket [chemical binding]; other site 208964003632 active site 208964003633 iron coordination sites [ion binding]; other site 208964003634 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 208964003635 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 208964003636 active site 208964003637 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 208964003638 Ligand Binding Site [chemical binding]; other site 208964003639 Molecular Tunnel; other site 208964003640 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 208964003641 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 208964003642 acyl-activating enzyme (AAE) consensus motif; other site 208964003643 AMP binding site [chemical binding]; other site 208964003644 active site 208964003645 CoA binding site [chemical binding]; other site 208964003646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964003647 S-adenosylmethionine binding site [chemical binding]; other site 208964003648 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 208964003649 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 208964003650 active site 208964003651 catalytic residues [active] 208964003652 metal binding site [ion binding]; metal-binding site 208964003653 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 208964003654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964003655 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964003656 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 208964003657 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 208964003658 acyl-activating enzyme (AAE) consensus motif; other site 208964003659 AMP binding site [chemical binding]; other site 208964003660 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964003661 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 208964003662 MltA specific insert domain; Region: MltA; smart00925 208964003663 3D domain; Region: 3D; pfam06725 208964003664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003666 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 208964003667 putative substrate binding pocket [chemical binding]; other site 208964003668 putative dimerization interface [polypeptide binding]; other site 208964003669 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 208964003670 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 208964003671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964003672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964003673 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 208964003674 Phosphotransferase enzyme family; Region: APH; pfam01636 208964003675 active site 208964003676 substrate binding site [chemical binding]; other site 208964003677 ATP binding site [chemical binding]; other site 208964003678 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 208964003679 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964003680 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964003681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964003682 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 208964003683 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 208964003684 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964003685 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964003686 Predicted membrane protein [Function unknown]; Region: COG1289 208964003687 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 208964003688 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 208964003689 Thioredoxin; Region: Thioredoxin_9; pfam14595 208964003690 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964003691 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964003692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964003693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964003694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003695 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 208964003696 putative substrate translocation pore; other site 208964003697 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 208964003698 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964003699 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964003700 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 208964003701 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964003702 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964003703 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 208964003704 enoyl-CoA hydratase; Provisional; Region: PRK06563 208964003705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964003706 substrate binding site [chemical binding]; other site 208964003707 oxyanion hole (OAH) forming residues; other site 208964003708 trimer interface [polypeptide binding]; other site 208964003709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964003710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964003711 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 208964003712 Subtilase family; Region: Peptidase_S8; pfam00082 208964003713 active site 208964003714 catalytic residues [active] 208964003715 PAS fold; Region: PAS_4; pfam08448 208964003716 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 208964003717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964003718 PAS domain; Region: PAS_9; pfam13426 208964003719 putative active site [active] 208964003720 heme pocket [chemical binding]; other site 208964003721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 208964003722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964003723 dimer interface [polypeptide binding]; other site 208964003724 phosphorylation site [posttranslational modification] 208964003725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964003726 ATP binding site [chemical binding]; other site 208964003727 Mg2+ binding site [ion binding]; other site 208964003728 G-X-G motif; other site 208964003729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964003730 active site 208964003731 phosphorylation site [posttranslational modification] 208964003732 intermolecular recognition site; other site 208964003733 dimerization interface [polypeptide binding]; other site 208964003734 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 208964003735 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208964003736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964003737 Walker A/P-loop; other site 208964003738 ATP binding site [chemical binding]; other site 208964003739 Q-loop/lid; other site 208964003740 ABC transporter signature motif; other site 208964003741 Walker B; other site 208964003742 D-loop; other site 208964003743 H-loop/switch region; other site 208964003744 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 208964003745 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964003746 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 208964003747 dimer interface [polypeptide binding]; other site 208964003748 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964003749 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 208964003750 Outer membrane efflux protein; Region: OEP; pfam02321 208964003751 Outer membrane efflux protein; Region: OEP; pfam02321 208964003752 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 208964003753 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 208964003754 active site 208964003755 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 208964003756 Protease inhibitor Inh; Region: Inh; pfam02974 208964003757 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 208964003758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964003759 dimerization interface [polypeptide binding]; other site 208964003760 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964003761 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964003762 dimer interface [polypeptide binding]; other site 208964003763 putative CheW interface [polypeptide binding]; other site 208964003764 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 208964003765 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 208964003766 dimer interface [polypeptide binding]; other site 208964003767 NADP binding site [chemical binding]; other site 208964003768 catalytic residues [active] 208964003769 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 208964003770 inhibitor site; inhibition site 208964003771 active site 208964003772 dimer interface [polypeptide binding]; other site 208964003773 catalytic residue [active] 208964003774 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 208964003775 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 208964003776 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208964003777 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208964003778 Walker A/P-loop; other site 208964003779 ATP binding site [chemical binding]; other site 208964003780 Q-loop/lid; other site 208964003781 ABC transporter signature motif; other site 208964003782 Walker B; other site 208964003783 D-loop; other site 208964003784 H-loop/switch region; other site 208964003785 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964003786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964003787 dimer interface [polypeptide binding]; other site 208964003788 conserved gate region; other site 208964003789 putative PBP binding loops; other site 208964003790 ABC-ATPase subunit interface; other site 208964003791 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964003792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964003793 dimer interface [polypeptide binding]; other site 208964003794 conserved gate region; other site 208964003795 putative PBP binding loops; other site 208964003796 ABC-ATPase subunit interface; other site 208964003797 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 208964003798 substrate binding site [chemical binding]; other site 208964003799 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 208964003800 substrate binding site [chemical binding]; other site 208964003801 ligand binding site [chemical binding]; other site 208964003802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964003803 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964003804 substrate binding pocket [chemical binding]; other site 208964003805 membrane-bound complex binding site; other site 208964003806 hinge residues; other site 208964003807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964003808 PAS domain; Region: PAS_9; pfam13426 208964003809 putative active site [active] 208964003810 heme pocket [chemical binding]; other site 208964003811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964003812 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964003813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964003814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964003816 putative substrate translocation pore; other site 208964003817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964003818 salt bridge; other site 208964003819 non-specific DNA binding site [nucleotide binding]; other site 208964003820 sequence-specific DNA binding site [nucleotide binding]; other site 208964003821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964003824 dimerization interface [polypeptide binding]; other site 208964003825 EamA-like transporter family; Region: EamA; pfam00892 208964003826 EamA-like transporter family; Region: EamA; pfam00892 208964003827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 208964003828 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 208964003829 FAD dependent oxidoreductase; Region: DAO; pfam01266 208964003830 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964003831 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 208964003832 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 208964003833 Transcriptional regulators [Transcription]; Region: GntR; COG1802 208964003834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964003835 DNA-binding site [nucleotide binding]; DNA binding site 208964003836 FCD domain; Region: FCD; pfam07729 208964003837 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 208964003838 Fusaric acid resistance protein family; Region: FUSC; pfam04632 208964003839 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 208964003840 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 208964003841 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964003842 N-terminal plug; other site 208964003843 ligand-binding site [chemical binding]; other site 208964003844 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 208964003845 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 208964003846 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 208964003847 homodimer interface [polypeptide binding]; other site 208964003848 Walker A motif; other site 208964003849 ATP binding site [chemical binding]; other site 208964003850 hydroxycobalamin binding site [chemical binding]; other site 208964003851 Walker B motif; other site 208964003852 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 208964003853 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 208964003854 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 208964003855 catalytic triad [active] 208964003856 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 208964003857 putative FMN binding site [chemical binding]; other site 208964003858 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 208964003859 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 208964003860 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964003861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964003862 homodimer interface [polypeptide binding]; other site 208964003863 catalytic residue [active] 208964003864 cobyric acid synthase; Provisional; Region: PRK00784 208964003865 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 208964003866 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 208964003867 catalytic triad [active] 208964003868 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Validated; Region: cobU; PRK05800 208964003869 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 208964003870 putative dimer interface [polypeptide binding]; other site 208964003871 active site pocket [active] 208964003872 putative cataytic base [active] 208964003873 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 208964003874 catalytic core [active] 208964003875 Protein of unknown function (DUF505); Region: DUF505; cl19549 208964003876 cobalamin synthase; Reviewed; Region: cobS; PRK00235 208964003877 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 208964003878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003879 putative substrate translocation pore; other site 208964003880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964003881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964003882 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 208964003883 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 208964003884 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964003885 active site 208964003886 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 208964003887 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964003888 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964003889 putative DNA binding site [nucleotide binding]; other site 208964003890 putative Zn2+ binding site [ion binding]; other site 208964003891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003892 putative substrate translocation pore; other site 208964003893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964003894 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 208964003895 catalytic residues [active] 208964003896 dimer interface [polypeptide binding]; other site 208964003897 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 208964003898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964003899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964003900 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 208964003901 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 208964003902 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 208964003903 active site residue [active] 208964003904 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 208964003905 active site residue [active] 208964003906 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 208964003907 Strictosidine synthase; Region: Str_synth; cl19733 208964003908 ribonuclease D; Region: rnd; TIGR01388 208964003909 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 208964003910 catalytic site [active] 208964003911 putative active site [active] 208964003912 putative substrate binding site [chemical binding]; other site 208964003913 HRDC domain; Region: HRDC; pfam00570 208964003914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 208964003915 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 208964003916 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 208964003917 NAD binding site [chemical binding]; other site 208964003918 ligand binding site [chemical binding]; other site 208964003919 catalytic site [active] 208964003920 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 208964003921 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 208964003922 putative metal binding site [ion binding]; other site 208964003923 putative homodimer interface [polypeptide binding]; other site 208964003924 putative homotetramer interface [polypeptide binding]; other site 208964003925 putative homodimer-homodimer interface [polypeptide binding]; other site 208964003926 putative allosteric switch controlling residues; other site 208964003927 hypothetical protein; Provisional; Region: PRK05170 208964003928 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 208964003929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964003930 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964003931 DNA binding residues [nucleotide binding] 208964003932 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964003933 FecR protein; Region: FecR; pfam04773 208964003934 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964003935 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 208964003936 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964003937 N-terminal plug; other site 208964003938 ligand-binding site [chemical binding]; other site 208964003939 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 208964003940 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 208964003941 Catalytic site [active] 208964003942 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 208964003943 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 208964003944 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 208964003945 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 208964003946 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 208964003947 nucleotide binding site/active site [active] 208964003948 HIT family signature motif; other site 208964003949 catalytic residue [active] 208964003950 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 208964003951 putative active site [active] 208964003952 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 208964003953 putative dimer interface [polypeptide binding]; other site 208964003954 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 208964003955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003956 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 208964003957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964003958 dimerization interface [polypeptide binding]; other site 208964003959 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 208964003960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964003961 catalytic residue [active] 208964003962 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 208964003963 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 208964003964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964003965 motif II; other site 208964003966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964003967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964003968 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964003969 putative effector binding pocket; other site 208964003970 dimerization interface [polypeptide binding]; other site 208964003971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964003973 putative substrate translocation pore; other site 208964003974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 208964003975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964003976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964003977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964003978 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964003979 putative substrate translocation pore; other site 208964003980 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 208964003981 TspO/MBR family; Region: TspO_MBR; cl01379 208964003982 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 208964003983 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 208964003984 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 208964003985 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 208964003986 D-pathway; other site 208964003987 Putative ubiquinol binding site [chemical binding]; other site 208964003988 Low-spin heme (heme b) binding site [chemical binding]; other site 208964003989 Putative water exit pathway; other site 208964003990 Binuclear center (heme o3/CuB) [ion binding]; other site 208964003991 K-pathway; other site 208964003992 Putative proton exit pathway; other site 208964003993 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 208964003994 Subunit I/III interface [polypeptide binding]; other site 208964003995 Subunit III/IV interface [polypeptide binding]; other site 208964003996 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 208964003997 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 208964003998 putative active site [active] 208964003999 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 208964004000 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964004001 N-terminal plug; other site 208964004002 ligand-binding site [chemical binding]; other site 208964004003 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 208964004004 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 208964004005 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 208964004006 threonine dehydratase; Reviewed; Region: PRK09224 208964004007 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 208964004008 tetramer interface [polypeptide binding]; other site 208964004009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964004010 catalytic residue [active] 208964004011 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 208964004012 putative Ile/Val binding site [chemical binding]; other site 208964004013 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 208964004014 putative Ile/Val binding site [chemical binding]; other site 208964004015 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 208964004016 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 208964004017 active site 208964004018 substrate binding site [chemical binding]; other site 208964004019 Mg2+ binding site [ion binding]; other site 208964004020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964004021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964004022 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 208964004023 putative effector binding pocket; other site 208964004024 putative dimerization interface [polypeptide binding]; other site 208964004025 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 208964004026 short chain dehydrogenase; Provisional; Region: PRK09291 208964004027 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 208964004028 NADP binding site [chemical binding]; other site 208964004029 active site 208964004030 steroid binding site; other site 208964004031 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 208964004032 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 208964004033 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 208964004034 Transporter associated domain; Region: CorC_HlyC; smart01091 208964004035 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 208964004036 FMN binding site [chemical binding]; other site 208964004037 active site 208964004038 substrate binding site [chemical binding]; other site 208964004039 catalytic residue [active] 208964004040 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964004042 active site 208964004043 phosphorylation site [posttranslational modification] 208964004044 intermolecular recognition site; other site 208964004045 dimerization interface [polypeptide binding]; other site 208964004046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964004047 Walker A motif; other site 208964004048 ATP binding site [chemical binding]; other site 208964004049 Walker B motif; other site 208964004050 arginine finger; other site 208964004051 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964004052 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 208964004053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964004054 dimer interface [polypeptide binding]; other site 208964004055 phosphorylation site [posttranslational modification] 208964004056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964004057 ATP binding site [chemical binding]; other site 208964004058 Mg2+ binding site [ion binding]; other site 208964004059 G-X-G motif; other site 208964004060 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 208964004061 homodimer interface [polypeptide binding]; other site 208964004062 active site 208964004063 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 208964004064 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208964004065 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208964004066 Walker A/P-loop; other site 208964004067 ATP binding site [chemical binding]; other site 208964004068 Q-loop/lid; other site 208964004069 ABC transporter signature motif; other site 208964004070 Walker B; other site 208964004071 D-loop; other site 208964004072 H-loop/switch region; other site 208964004073 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964004074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964004075 dimer interface [polypeptide binding]; other site 208964004076 conserved gate region; other site 208964004077 putative PBP binding loops; other site 208964004078 ABC-ATPase subunit interface; other site 208964004079 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964004080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964004081 dimer interface [polypeptide binding]; other site 208964004082 conserved gate region; other site 208964004083 putative PBP binding loops; other site 208964004084 ABC-ATPase subunit interface; other site 208964004085 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 208964004086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964004087 substrate binding pocket [chemical binding]; other site 208964004088 membrane-bound complex binding site; other site 208964004089 hinge residues; other site 208964004090 short chain dehydrogenase; Provisional; Region: PRK06523 208964004091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964004092 NAD(P) binding site [chemical binding]; other site 208964004093 active site 208964004094 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 208964004095 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 208964004096 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964004097 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 208964004098 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 208964004099 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 208964004100 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 208964004101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964004102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964004103 DNA binding residues [nucleotide binding] 208964004104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 208964004105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 208964004106 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 208964004107 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964004108 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964004109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964004110 putative substrate translocation pore; other site 208964004111 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964004112 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 208964004113 dimer interface [polypeptide binding]; other site 208964004114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 208964004115 ThiS family; Region: ThiS; pfam02597 208964004116 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 208964004117 putative deacylase active site [active] 208964004118 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 208964004119 dimer interface [polypeptide binding]; other site 208964004120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964004121 non-specific DNA binding site [nucleotide binding]; other site 208964004122 salt bridge; other site 208964004123 sequence-specific DNA binding site [nucleotide binding]; other site 208964004124 Cupin domain; Region: Cupin_2; pfam07883 208964004125 threonine and homoserine efflux system; Provisional; Region: PRK10532 208964004126 EamA-like transporter family; Region: EamA; pfam00892 208964004127 multidrug efflux protein; Reviewed; Region: PRK01766 208964004128 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 208964004129 cation binding site [ion binding]; other site 208964004130 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 208964004131 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964004132 DNA binding residues [nucleotide binding] 208964004133 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964004134 FecR protein; Region: FecR; pfam04773 208964004135 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964004136 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 208964004137 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964004138 N-terminal plug; other site 208964004139 ligand-binding site [chemical binding]; other site 208964004140 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 208964004141 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 208964004142 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 208964004143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 208964004144 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 208964004145 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 208964004146 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 208964004147 Uncharacterized conserved protein [Function unknown]; Region: COG5619 208964004148 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 208964004149 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 208964004150 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 208964004151 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 208964004152 dimer interface [polypeptide binding]; other site 208964004153 active site 208964004154 Predicted transcriptional regulators [Transcription]; Region: COG1733 208964004155 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 208964004156 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 208964004157 ligand binding site [chemical binding]; other site 208964004158 NAD binding site [chemical binding]; other site 208964004159 catalytic site [active] 208964004160 homodimer interface [polypeptide binding]; other site 208964004161 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 208964004162 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 208964004163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964004164 Coenzyme A binding pocket [chemical binding]; other site 208964004165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208964004166 short chain dehydrogenase; Provisional; Region: PRK06180 208964004167 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 208964004168 NADP binding site [chemical binding]; other site 208964004169 active site 208964004170 steroid binding site; other site 208964004171 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 208964004172 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964004173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964004174 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 208964004175 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964004176 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964004177 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964004178 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 208964004179 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 208964004180 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 208964004181 NAD binding site [chemical binding]; other site 208964004182 homodimer interface [polypeptide binding]; other site 208964004183 active site 208964004184 substrate binding site [chemical binding]; other site 208964004185 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 208964004186 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964004187 putative ADP-binding pocket [chemical binding]; other site 208964004188 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 208964004189 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 208964004190 Walker A/P-loop; other site 208964004191 ATP binding site [chemical binding]; other site 208964004192 Q-loop/lid; other site 208964004193 ABC transporter signature motif; other site 208964004194 Walker B; other site 208964004195 D-loop; other site 208964004196 H-loop/switch region; other site 208964004197 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 208964004198 putative carbohydrate binding site [chemical binding]; other site 208964004199 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 208964004200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208964004201 active site 208964004202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964004203 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208964004204 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 208964004205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208964004206 active site 208964004207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964004208 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 208964004209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 208964004210 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 208964004211 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 208964004212 ligand-binding site [chemical binding]; other site 208964004213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964004214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964004215 dimer interface [polypeptide binding]; other site 208964004216 phosphorylation site [posttranslational modification] 208964004217 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 208964004218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964004219 ATP binding site [chemical binding]; other site 208964004220 Mg2+ binding site [ion binding]; other site 208964004221 G-X-G motif; other site 208964004222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964004223 active site 208964004224 phosphorylation site [posttranslational modification] 208964004225 intermolecular recognition site; other site 208964004226 dimerization interface [polypeptide binding]; other site 208964004227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964004228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964004229 active site 208964004230 phosphorylation site [posttranslational modification] 208964004231 intermolecular recognition site; other site 208964004232 dimerization interface [polypeptide binding]; other site 208964004233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964004234 DNA binding residues [nucleotide binding] 208964004235 dimerization interface [polypeptide binding]; other site 208964004236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964004237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964004238 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 208964004239 substrate binding pocket [chemical binding]; other site 208964004240 dimerization interface [polypeptide binding]; other site 208964004241 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 208964004242 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208964004243 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964004244 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 208964004245 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 208964004246 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208964004247 carboxyltransferase (CT) interaction site; other site 208964004248 biotinylation site [posttranslational modification]; other site 208964004249 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 208964004250 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 208964004251 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 208964004252 Predicted ester cyclase [General function prediction only]; Region: COG5485 208964004253 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 208964004254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964004255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964004256 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 208964004257 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 208964004258 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 208964004259 active site 208964004260 NTP binding site [chemical binding]; other site 208964004261 metal binding triad [ion binding]; metal-binding site 208964004262 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 208964004263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964004264 S-adenosylmethionine binding site [chemical binding]; other site 208964004265 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 208964004266 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 208964004267 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208964004268 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 208964004269 active site 208964004270 Zn binding site [ion binding]; other site 208964004271 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 208964004272 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964004273 EamA-like transporter family; Region: EamA; pfam00892 208964004274 EamA-like transporter family; Region: EamA; pfam00892 208964004275 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964004276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964004277 putative substrate translocation pore; other site 208964004278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964004279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964004280 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 208964004281 putative dimerization interface [polypeptide binding]; other site 208964004282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208964004283 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 208964004284 FAD binding domain; Region: FAD_binding_4; pfam01565 208964004285 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 208964004286 hypothetical protein; Provisional; Region: PRK07524 208964004287 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 208964004288 PYR/PP interface [polypeptide binding]; other site 208964004289 dimer interface [polypeptide binding]; other site 208964004290 TPP binding site [chemical binding]; other site 208964004291 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964004292 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 208964004293 TPP-binding site [chemical binding]; other site 208964004294 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 208964004295 Na binding site [ion binding]; other site 208964004296 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 208964004297 Na binding site [ion binding]; other site 208964004298 SnoaL-like domain; Region: SnoaL_3; pfam13474 208964004299 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 208964004300 oligomer interface [polypeptide binding]; other site 208964004301 putative active site [active] 208964004302 Mn binding site [ion binding]; other site 208964004303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964004304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964004305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964004306 dimerization interface [polypeptide binding]; other site 208964004307 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 208964004308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964004309 putative active site [active] 208964004310 heme pocket [chemical binding]; other site 208964004311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964004312 putative active site [active] 208964004313 heme pocket [chemical binding]; other site 208964004314 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964004315 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964004316 dimer interface [polypeptide binding]; other site 208964004317 putative CheW interface [polypeptide binding]; other site 208964004318 Uncharacterized conserved protein [Function unknown]; Region: COG3148 208964004319 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 208964004320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964004321 Walker A/P-loop; other site 208964004322 ATP binding site [chemical binding]; other site 208964004323 Q-loop/lid; other site 208964004324 ABC transporter signature motif; other site 208964004325 Walker B; other site 208964004326 D-loop; other site 208964004327 H-loop/switch region; other site 208964004328 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964004329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964004330 ABC transporter signature motif; other site 208964004331 Walker B; other site 208964004332 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 208964004333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208964004334 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 208964004335 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 208964004336 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208964004337 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 208964004338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964004339 motif II; other site 208964004340 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 208964004341 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 208964004342 Autoinducer binding domain; Region: Autoind_bind; pfam03472 208964004343 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964004344 DNA binding residues [nucleotide binding] 208964004345 dimerization interface [polypeptide binding]; other site 208964004346 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 208964004347 biofilm formation regulator HmsP; Provisional; Region: PRK11829 208964004348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964004349 dimerization interface [polypeptide binding]; other site 208964004350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964004351 active site 208964004352 I-site; other site 208964004353 metal binding site [ion binding]; metal-binding site 208964004354 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964004355 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 208964004356 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964004357 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964004358 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 208964004359 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964004360 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 208964004361 MMPL family; Region: MMPL; cl14618 208964004362 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 208964004363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964004364 active site 208964004365 phosphorylation site [posttranslational modification] 208964004366 intermolecular recognition site; other site 208964004367 dimerization interface [polypeptide binding]; other site 208964004368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964004369 DNA binding site [nucleotide binding] 208964004370 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 208964004371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964004372 dimerization interface [polypeptide binding]; other site 208964004373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964004374 dimer interface [polypeptide binding]; other site 208964004375 phosphorylation site [posttranslational modification] 208964004376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964004377 ATP binding site [chemical binding]; other site 208964004378 Mg2+ binding site [ion binding]; other site 208964004379 G-X-G motif; other site 208964004380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 208964004381 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 208964004382 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 208964004383 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 208964004384 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 208964004385 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 208964004386 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 208964004387 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 208964004388 flagellar motor switch protein; Validated; Region: fliN; PRK05698 208964004389 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 208964004390 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 208964004391 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 208964004392 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 208964004393 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 208964004394 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 208964004395 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 208964004396 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 208964004397 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 208964004398 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 208964004399 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 208964004400 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 208964004401 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 208964004402 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 208964004403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964004404 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 208964004405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964004406 DNA binding residues [nucleotide binding] 208964004407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964004408 active site 208964004409 phosphorylation site [posttranslational modification] 208964004410 intermolecular recognition site; other site 208964004411 dimerization interface [polypeptide binding]; other site 208964004412 Chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheZ; COG3143 208964004413 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 208964004414 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964004415 putative binding surface; other site 208964004416 active site 208964004417 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 208964004418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964004419 ATP binding site [chemical binding]; other site 208964004420 Mg2+ binding site [ion binding]; other site 208964004421 G-X-G motif; other site 208964004422 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 208964004423 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 208964004424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964004425 active site 208964004426 phosphorylation site [posttranslational modification] 208964004427 intermolecular recognition site; other site 208964004428 dimerization interface [polypeptide binding]; other site 208964004429 CheB methylesterase; Region: CheB_methylest; pfam01339 208964004430 flagellar motor protein; Reviewed; Region: motC; PRK09109 208964004431 flagellar motor protein MotD; Reviewed; Region: PRK09038 208964004432 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 208964004433 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964004434 ligand binding site [chemical binding]; other site 208964004435 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 208964004436 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 208964004437 P-loop; other site 208964004438 Magnesium ion binding site [ion binding]; other site 208964004439 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 208964004440 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 208964004441 putative CheA interaction surface; other site 208964004442 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 208964004443 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 208964004444 C-terminal domain interface [polypeptide binding]; other site 208964004445 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964004446 GSH binding site (G-site) [chemical binding]; other site 208964004447 dimer interface [polypeptide binding]; other site 208964004448 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 208964004449 N-terminal domain interface [polypeptide binding]; other site 208964004450 dimer interface [polypeptide binding]; other site 208964004451 substrate binding pocket (H-site) [chemical binding]; other site 208964004452 Predicted transcriptional regulator [Transcription]; Region: COG2378 208964004453 HTH domain; Region: HTH_11; pfam08279 208964004454 WYL domain; Region: WYL; pfam13280 208964004455 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 208964004456 short chain dehydrogenase; Provisional; Region: PRK12937 208964004457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964004458 NAD(P) binding site [chemical binding]; other site 208964004459 active site 208964004460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208964004461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208964004462 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 208964004463 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 208964004464 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 208964004465 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 208964004466 Walker A/P-loop; other site 208964004467 ATP binding site [chemical binding]; other site 208964004468 Q-loop/lid; other site 208964004469 ABC transporter signature motif; other site 208964004470 Walker B; other site 208964004471 D-loop; other site 208964004472 H-loop/switch region; other site 208964004473 heme exporter protein CcmB; Region: ccmB; TIGR01190 208964004474 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 208964004475 heme exporter protein CcmC; Region: ccmC; TIGR01191 208964004476 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 208964004477 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 208964004478 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 208964004479 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 208964004480 catalytic residues [active] 208964004481 central insert; other site 208964004482 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 208964004483 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 208964004484 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 208964004485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964004486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964004487 DNA binding residues [nucleotide binding] 208964004488 dimerization interface [polypeptide binding]; other site 208964004489 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208964004490 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964004491 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 208964004492 homodimer interface [polypeptide binding]; other site 208964004493 homotetramer interface [polypeptide binding]; other site 208964004494 active site pocket [active] 208964004495 cleavage site 208964004496 Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794 208964004497 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 208964004498 N- and C-terminal domain interface [polypeptide binding]; other site 208964004499 active site 208964004500 MgATP binding site [chemical binding]; other site 208964004501 catalytic site [active] 208964004502 metal binding site [ion binding]; metal-binding site 208964004503 putative homotetramer interface [polypeptide binding]; other site 208964004504 putative homodimer interface [polypeptide binding]; other site 208964004505 putative glycerol binding site [chemical binding]; other site 208964004506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 208964004507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964004508 Predicted dehydrogenase [General function prediction only]; Region: COG0579 208964004509 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 208964004510 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 208964004511 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 208964004512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964004513 putative DNA binding site [nucleotide binding]; other site 208964004514 putative Zn2+ binding site [ion binding]; other site 208964004515 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 208964004516 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 208964004517 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 208964004518 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 208964004519 conserved hypothetical protein; Region: TIGR02231 208964004520 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 208964004521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 208964004522 Ion transport protein; Region: Ion_trans; pfam00520 208964004523 Ion channel; Region: Ion_trans_2; pfam07885 208964004524 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 208964004525 pyruvate kinase; Provisional; Region: PRK06247 208964004526 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 208964004527 domain interfaces; other site 208964004528 active site 208964004529 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 208964004530 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 208964004531 MOFRL family; Region: MOFRL; pfam05161 208964004532 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 208964004533 tartronate semialdehyde reductase; Provisional; Region: PRK15059 208964004534 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 208964004535 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 208964004536 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 208964004537 glyoxylate carboligase; Provisional; Region: PRK11269 208964004538 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 208964004539 PYR/PP interface [polypeptide binding]; other site 208964004540 dimer interface [polypeptide binding]; other site 208964004541 TPP binding site [chemical binding]; other site 208964004542 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964004543 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 208964004544 TPP-binding site [chemical binding]; other site 208964004545 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 208964004546 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 208964004547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964004548 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 208964004549 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 208964004550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964004551 FeS/SAM binding site; other site 208964004552 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 208964004553 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 208964004554 active site 208964004555 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964004556 xanthine permease; Region: pbuX; TIGR03173 208964004557 PAAR motif; Region: PAAR_motif; pfam05488 208964004558 PGAP1-like protein; Region: PGAP1; pfam07819 208964004559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 208964004560 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964004561 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964004562 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 208964004563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 208964004564 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 208964004565 Predicted membrane protein [Function unknown]; Region: COG3748 208964004566 Protein of unknown function (DUF989); Region: DUF989; pfam06181 208964004567 Cytochrome c; Region: Cytochrom_C; pfam00034 208964004568 ureidoglycolate hydrolase; Provisional; Region: PRK03606 208964004569 Allantoicase [Nucleotide transport and metabolism]; Region: Alc; COG4266 208964004570 Allantoicase repeat; Region: Allantoicase; pfam03561 208964004571 Allantoicase repeat; Region: Allantoicase; pfam03561 208964004572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 208964004573 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 208964004574 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 208964004575 active site 208964004576 catalytic site [active] 208964004577 tetramer interface [polypeptide binding]; other site 208964004578 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 208964004579 active site 208964004580 homotetramer interface [polypeptide binding]; other site 208964004581 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 208964004582 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964004583 Transcriptional regulators [Transcription]; Region: GntR; COG1802 208964004584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964004585 DNA-binding site [nucleotide binding]; DNA binding site 208964004586 FCD domain; Region: FCD; pfam07729 208964004587 guanine deaminase; Provisional; Region: PRK09228 208964004588 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 208964004589 active site 208964004590 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 208964004591 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 208964004592 XdhC Rossmann domain; Region: XdhC_C; pfam13478 208964004593 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 208964004594 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 208964004595 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964004596 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 208964004597 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964004598 catalytic loop [active] 208964004599 iron binding site [ion binding]; other site 208964004600 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 208964004601 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 208964004602 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 208964004603 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 208964004604 Di-iron ligands [ion binding]; other site 208964004605 Transcriptional regulators [Transcription]; Region: GntR; COG1802 208964004606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964004607 DNA-binding site [nucleotide binding]; DNA binding site 208964004608 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 208964004609 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 208964004610 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 208964004611 Walker A/P-loop; other site 208964004612 ATP binding site [chemical binding]; other site 208964004613 Q-loop/lid; other site 208964004614 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 208964004615 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 208964004616 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 208964004617 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 208964004618 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 208964004619 ABC transporter signature motif; other site 208964004620 Walker B; other site 208964004621 D-loop; other site 208964004622 H-loop/switch region; other site 208964004623 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 208964004624 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 208964004625 FtsZ protein binding site [polypeptide binding]; other site 208964004626 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 208964004627 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 208964004628 nucleotide binding pocket [chemical binding]; other site 208964004629 K-X-D-G motif; other site 208964004630 catalytic site [active] 208964004631 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 208964004632 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 208964004633 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 208964004634 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 208964004635 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 208964004636 Dimer interface [polypeptide binding]; other site 208964004637 BRCT sequence motif; other site 208964004638 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964004639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964004640 substrate binding pocket [chemical binding]; other site 208964004641 membrane-bound complex binding site; other site 208964004642 hinge residues; other site 208964004643 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 208964004644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964004645 Walker A motif; other site 208964004646 ATP binding site [chemical binding]; other site 208964004647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 208964004648 Walker B motif; other site 208964004649 arginine finger; other site 208964004650 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 208964004651 hypothetical protein; Validated; Region: PRK00153 208964004652 recombination protein RecR; Reviewed; Region: recR; PRK00076 208964004653 RecR protein; Region: RecR; pfam02132 208964004654 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 208964004655 putative active site [active] 208964004656 putative metal-binding site [ion binding]; other site 208964004657 tetramer interface [polypeptide binding]; other site 208964004658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964004659 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964004660 active site 208964004661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 208964004662 hypothetical protein; Provisional; Region: PRK06194 208964004663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964004664 NAD(P) binding site [chemical binding]; other site 208964004665 active site 208964004666 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 208964004667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 208964004668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964004669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964004670 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 208964004671 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 208964004672 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 208964004673 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964004674 active site 208964004675 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 208964004676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208964004677 ligand binding site [chemical binding]; other site 208964004678 flexible hinge region; other site 208964004679 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 208964004680 putative switch regulator; other site 208964004681 non-specific DNA interactions [nucleotide binding]; other site 208964004682 DNA binding site [nucleotide binding] 208964004683 sequence specific DNA binding site [nucleotide binding]; other site 208964004684 putative cAMP binding site [chemical binding]; other site 208964004685 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 208964004686 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 208964004687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964004688 FeS/SAM binding site; other site 208964004689 HemN C-terminal domain; Region: HemN_C; pfam06969 208964004690 Uncharacterized conserved protein [Function unknown]; Region: COG2836 208964004691 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 208964004692 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 208964004693 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 208964004694 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208964004695 metal-binding site [ion binding] 208964004696 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208964004697 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 208964004698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 208964004699 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 208964004700 4Fe-4S binding domain; Region: Fer4_5; pfam12801 208964004701 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 208964004702 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 208964004703 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 208964004704 N-terminal domain of cytochrome oxidase-cbb3, FixP; Region: FixP_N; pfam14715 208964004705 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964004706 Cytochrome c; Region: Cytochrom_C; cl11414 208964004707 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 208964004708 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 208964004709 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 208964004710 Low-spin heme binding site [chemical binding]; other site 208964004711 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 208964004712 D-pathway; other site 208964004713 Putative water exit pathway; other site 208964004714 Binuclear center (active site) [active] 208964004715 K-pathway; other site 208964004716 Putative proton exit pathway; other site 208964004717 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 208964004718 N-terminal domain of cytochrome oxidase-cbb3, FixP; Region: FixP_N; pfam14715 208964004719 Cytochrome c; Region: Cytochrom_C; pfam00034 208964004720 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964004721 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 208964004722 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 208964004723 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 208964004724 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 208964004725 Low-spin heme binding site [chemical binding]; other site 208964004726 Putative water exit pathway; other site 208964004727 Binuclear center (active site) [active] 208964004728 Putative proton exit pathway; other site 208964004729 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 208964004730 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208964004731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964004732 PAS fold; Region: PAS_3; pfam08447 208964004733 putative active site [active] 208964004734 heme pocket [chemical binding]; other site 208964004735 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 208964004736 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964004737 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964004738 dimer interface [polypeptide binding]; other site 208964004739 putative CheW interface [polypeptide binding]; other site 208964004740 aconitate hydratase; Validated; Region: PRK09277 208964004741 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 208964004742 substrate binding site [chemical binding]; other site 208964004743 ligand binding site [chemical binding]; other site 208964004744 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 208964004745 substrate binding site [chemical binding]; other site 208964004746 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 208964004747 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 208964004748 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 208964004749 CPxP motif; other site 208964004750 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964004751 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964004752 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208964004753 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208964004754 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964004755 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964004756 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 208964004757 homotrimer interaction site [polypeptide binding]; other site 208964004758 putative active site [active] 208964004759 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 208964004760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964004761 putative substrate translocation pore; other site 208964004762 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 208964004763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964004764 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964004765 dimerization interface [polypeptide binding]; other site 208964004766 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 208964004767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 208964004768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3123 208964004769 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 208964004770 active site 208964004771 catalytic site [active] 208964004772 substrate binding site [chemical binding]; other site 208964004773 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 208964004774 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 208964004775 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 208964004776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 208964004777 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 208964004778 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 208964004779 putative lipid binding site [chemical binding]; other site 208964004780 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 208964004781 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 208964004782 dimer interface [polypeptide binding]; other site 208964004783 active site 208964004784 citrylCoA binding site [chemical binding]; other site 208964004785 NADH binding [chemical binding]; other site 208964004786 cationic pore residues; other site 208964004787 oxalacetate/citrate binding site [chemical binding]; other site 208964004788 coenzyme A binding site [chemical binding]; other site 208964004789 catalytic triad [active] 208964004790 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 208964004791 Iron-sulfur protein interface; other site 208964004792 proximal quinone binding site [chemical binding]; other site 208964004793 SdhD (CybS) interface [polypeptide binding]; other site 208964004794 proximal heme binding site [chemical binding]; other site 208964004795 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 208964004796 SdhC subunit interface [polypeptide binding]; other site 208964004797 proximal heme binding site [chemical binding]; other site 208964004798 cardiolipin binding site; other site 208964004799 Iron-sulfur protein interface; other site 208964004800 proximal quinone binding site [chemical binding]; other site 208964004801 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 208964004802 L-aspartate oxidase; Provisional; Region: PRK06175 208964004803 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 208964004804 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 208964004805 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 208964004806 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 208964004807 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 208964004808 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 208964004809 TPP-binding site [chemical binding]; other site 208964004810 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 208964004811 PYR/PP interface [polypeptide binding]; other site 208964004812 dimer interface [polypeptide binding]; other site 208964004813 TPP binding site [chemical binding]; other site 208964004814 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 208964004815 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 208964004816 E3 interaction surface; other site 208964004817 lipoyl attachment site [posttranslational modification]; other site 208964004818 e3 binding domain; Region: E3_binding; pfam02817 208964004819 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 208964004820 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 208964004821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964004822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964004823 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 208964004824 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 208964004825 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 208964004826 CoA-ligase; Region: Ligase_CoA; pfam00549 208964004827 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 208964004828 CoA binding domain; Region: CoA_binding; pfam02629 208964004829 CoA-ligase; Region: Ligase_CoA; pfam00549 208964004830 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 208964004831 Predicted membrane protein [Function unknown]; Region: COG3821 208964004832 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964004833 CoenzymeA binding site [chemical binding]; other site 208964004834 subunit interaction site [polypeptide binding]; other site 208964004835 PHB binding site; other site 208964004836 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964004837 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 208964004838 CoenzymeA binding site [chemical binding]; other site 208964004839 subunit interaction site [polypeptide binding]; other site 208964004840 PHB binding site; other site 208964004841 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 208964004842 heat shock protein 90; Provisional; Region: PRK05218 208964004843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964004844 ATP binding site [chemical binding]; other site 208964004845 Mg2+ binding site [ion binding]; other site 208964004846 G-X-G motif; other site 208964004847 Hsp90 protein; Region: HSP90; pfam00183 208964004848 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 208964004849 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 208964004850 oligomerization interface [polypeptide binding]; other site 208964004851 active site 208964004852 metal binding site [ion binding]; metal-binding site 208964004853 Cupin domain; Region: Cupin_2; cl17218 208964004854 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964004855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964004856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964004857 Cytochrome c; Region: Cytochrom_C; cl11414 208964004858 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964004859 Cytochrome c; Region: Cytochrom_C; cl11414 208964004860 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964004861 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 208964004862 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964004863 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 208964004864 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964004865 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 208964004866 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964004867 catalytic loop [active] 208964004868 iron binding site [ion binding]; other site 208964004869 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 208964004870 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964004871 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208964004872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964004873 membrane-bound complex binding site; other site 208964004874 hinge residues; other site 208964004875 Amidohydrolase; Region: Amidohydro_2; pfam04909 208964004876 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 208964004877 Predicted transcriptional regulators [Transcription]; Region: COG1733 208964004878 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 208964004879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964004880 dimerization interface [polypeptide binding]; other site 208964004881 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964004882 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964004883 dimer interface [polypeptide binding]; other site 208964004884 putative CheW interface [polypeptide binding]; other site 208964004885 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 208964004886 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 208964004887 dimer interface [polypeptide binding]; other site 208964004888 active site 208964004889 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 208964004890 active site 1 [active] 208964004891 dimer interface [polypeptide binding]; other site 208964004892 active site 2 [active] 208964004893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964004894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964004895 dimerization interface [polypeptide binding]; other site 208964004896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964004897 dimer interface [polypeptide binding]; other site 208964004898 phosphorylation site [posttranslational modification] 208964004899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964004900 ATP binding site [chemical binding]; other site 208964004901 Mg2+ binding site [ion binding]; other site 208964004902 G-X-G motif; other site 208964004903 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964004904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964004905 active site 208964004906 phosphorylation site [posttranslational modification] 208964004907 intermolecular recognition site; other site 208964004908 dimerization interface [polypeptide binding]; other site 208964004909 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 208964004910 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964004911 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 208964004912 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 208964004913 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 208964004914 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 208964004915 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 208964004916 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 208964004917 catalytic core [active] 208964004918 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 208964004919 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 208964004920 acyl-activating enzyme (AAE) consensus motif; other site 208964004921 putative AMP binding site [chemical binding]; other site 208964004922 putative active site [active] 208964004923 putative CoA binding site [chemical binding]; other site 208964004924 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964004925 CoenzymeA binding site [chemical binding]; other site 208964004926 subunit interaction site [polypeptide binding]; other site 208964004927 PHB binding site; other site 208964004928 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964004929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964004930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964004931 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 208964004932 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964004933 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964004934 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964004935 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964004936 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 208964004937 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 208964004938 C-terminal domain interface [polypeptide binding]; other site 208964004939 GSH binding site (G-site) [chemical binding]; other site 208964004940 dimer interface [polypeptide binding]; other site 208964004941 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 208964004942 N-terminal domain interface [polypeptide binding]; other site 208964004943 dimer interface [polypeptide binding]; other site 208964004944 substrate binding pocket (H-site) [chemical binding]; other site 208964004945 Domain of unknown function DUF20; Region: UPF0118; cl00465 208964004946 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 208964004947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964004948 putative substrate translocation pore; other site 208964004949 Transcriptional regulators [Transcription]; Region: FadR; COG2186 208964004950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964004951 DNA-binding site [nucleotide binding]; DNA binding site 208964004952 FCD domain; Region: FCD; pfam07729 208964004953 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 208964004954 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 208964004955 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964004956 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964004957 enoyl-CoA hydratase; Provisional; Region: PRK08138 208964004958 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964004959 substrate binding site [chemical binding]; other site 208964004960 oxyanion hole (OAH) forming residues; other site 208964004961 trimer interface [polypeptide binding]; other site 208964004962 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 208964004963 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208964004964 Bacterial transcriptional regulator; Region: IclR; pfam01614 208964004965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964004966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964004967 active site 208964004968 potassium-transporting ATPase subunit F; Provisional; Region: kdbF; PRK14740 208964004969 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 208964004970 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 208964004971 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208964004972 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 208964004973 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 208964004974 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 208964004975 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 208964004976 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 208964004977 Ligand Binding Site [chemical binding]; other site 208964004978 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 208964004979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964004980 dimer interface [polypeptide binding]; other site 208964004981 phosphorylation site [posttranslational modification] 208964004982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964004983 ATP binding site [chemical binding]; other site 208964004984 Mg2+ binding site [ion binding]; other site 208964004985 G-X-G motif; other site 208964004986 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 208964004987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964004988 active site 208964004989 phosphorylation site [posttranslational modification] 208964004990 intermolecular recognition site; other site 208964004991 dimerization interface [polypeptide binding]; other site 208964004992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964004993 DNA binding site [nucleotide binding] 208964004994 glutaminase; Provisional; Region: PRK00971 208964004995 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 208964004996 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 208964004997 active site 208964004998 nucleophile elbow; other site 208964004999 selenophosphate synthetase; Provisional; Region: PRK00943 208964005000 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 208964005001 dimerization interface [polypeptide binding]; other site 208964005002 putative ATP binding site [chemical binding]; other site 208964005003 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 208964005004 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 208964005005 active site residue [active] 208964005006 AAA domain; Region: AAA_18; pfam13238 208964005007 Uncharacterized conserved protein [Function unknown]; Region: COG3791 208964005008 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 208964005009 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964005010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964005011 dimerization interface [polypeptide binding]; other site 208964005012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964005013 dimer interface [polypeptide binding]; other site 208964005014 putative CheW interface [polypeptide binding]; other site 208964005015 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 208964005016 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 208964005017 Sulfate transporter family; Region: Sulfate_transp; pfam00916 208964005018 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 208964005019 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 208964005020 Prostaglandin dehydrogenases; Region: PGDH; cd05288 208964005021 NAD(P) binding site [chemical binding]; other site 208964005022 substrate binding site [chemical binding]; other site 208964005023 dimer interface [polypeptide binding]; other site 208964005024 short chain dehydrogenase; Provisional; Region: PRK06172 208964005025 classical (c) SDRs; Region: SDR_c; cd05233 208964005026 NAD(P) binding site [chemical binding]; other site 208964005027 active site 208964005028 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 208964005029 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 208964005030 Benzoate membrane transport protein; Region: BenE; pfam03594 208964005031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964005032 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964005033 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 208964005034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964005035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964005036 homodimer interface [polypeptide binding]; other site 208964005037 catalytic residue [active] 208964005038 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964005039 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 208964005040 putative C-terminal domain interface [polypeptide binding]; other site 208964005041 putative GSH binding site (G-site) [chemical binding]; other site 208964005042 putative dimer interface [polypeptide binding]; other site 208964005043 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 208964005044 N-terminal domain interface [polypeptide binding]; other site 208964005045 dimer interface [polypeptide binding]; other site 208964005046 substrate binding pocket (H-site) [chemical binding]; other site 208964005047 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 208964005048 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 208964005049 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 208964005050 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 208964005051 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 208964005052 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 208964005053 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 208964005054 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 208964005055 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 208964005056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964005057 Walker A motif; other site 208964005058 ATP binding site [chemical binding]; other site 208964005059 Walker B motif; other site 208964005060 arginine finger; other site 208964005061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964005062 Walker A motif; other site 208964005063 ATP binding site [chemical binding]; other site 208964005064 Walker B motif; other site 208964005065 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 208964005066 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 208964005067 GAF domain; Region: GAF_2; pfam13185 208964005068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964005069 Walker A motif; other site 208964005070 ATP binding site [chemical binding]; other site 208964005071 Walker B motif; other site 208964005072 arginine finger; other site 208964005073 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964005074 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 208964005075 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 208964005076 phosphopeptide binding site; other site 208964005077 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 208964005078 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 208964005079 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 208964005080 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 208964005081 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 208964005082 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 208964005083 G1 box; other site 208964005084 GTP/Mg2+ binding site [chemical binding]; other site 208964005085 G2 box; other site 208964005086 Switch I region; other site 208964005087 G3 box; other site 208964005088 Switch II region; other site 208964005089 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 208964005090 G4 box; other site 208964005091 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 208964005092 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 208964005093 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 208964005094 active site 208964005095 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 208964005096 Catalytic domain of Protein Kinases; Region: PKc; cd00180 208964005097 active site 208964005098 ATP binding site [chemical binding]; other site 208964005099 substrate binding site [chemical binding]; other site 208964005100 activation loop (A-loop); other site 208964005101 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 208964005102 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 208964005103 Hemerythrin; Region: Hemerythrin; cd12107 208964005104 Fe binding site [ion binding]; other site 208964005105 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 208964005106 homodecamer interface [polypeptide binding]; other site 208964005107 active site 208964005108 putative catalytic site residues [active] 208964005109 zinc binding site [ion binding]; other site 208964005110 GTP-CH-I/GFRP interaction surface; other site 208964005111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 208964005112 Smr domain; Region: Smr; pfam01713 208964005113 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 208964005114 catalytic triad [active] 208964005115 conserved cis-peptide bond; other site 208964005116 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 208964005117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964005118 S-adenosylmethionine binding site [chemical binding]; other site 208964005119 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964005120 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964005121 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 208964005122 Tetramer interface [polypeptide binding]; other site 208964005123 active site 208964005124 FMN-binding site [chemical binding]; other site 208964005125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964005126 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964005127 putative substrate translocation pore; other site 208964005128 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 208964005129 intersubunit interface [polypeptide binding]; other site 208964005130 active site 208964005131 Zn2+ binding site [ion binding]; other site 208964005132 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 208964005133 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 208964005134 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 208964005135 AlkA N-terminal domain; Region: AlkA_N; pfam06029 208964005136 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 208964005137 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 208964005138 minor groove reading motif; other site 208964005139 helix-hairpin-helix signature motif; other site 208964005140 substrate binding pocket [chemical binding]; other site 208964005141 active site 208964005142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964005143 S-adenosylmethionine binding site [chemical binding]; other site 208964005144 Uncharacterized conserved protein [Function unknown]; Region: COG3391 208964005145 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 208964005146 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 208964005147 Sulfatase; Region: Sulfatase; pfam00884 208964005148 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 208964005149 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 208964005150 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 208964005151 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 208964005152 type III secretion system protein; Validated; Region: PRK06933 208964005153 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 208964005154 variable surface protein Vir28; Provisional; Region: PTZ00249 208964005155 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 208964005156 Type III secretion protein YscO; Region: YscO; pfam07321 208964005157 type III secretion system ATPase; Provisional; Region: PRK06936 208964005158 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 208964005159 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 208964005160 Walker A motif/ATP binding site; other site 208964005161 Walker B motif; other site 208964005162 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 208964005163 TyeA; Region: TyeA; pfam09059 208964005164 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 208964005165 type III secretion protein, YscX family; Region: type_III_YscX; TIGR02502 208964005166 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 208964005167 type III secretion system regulator LcrR; Region: LcrR; TIGR02572 208964005168 type III secretion protein LcrG; Region: LcrG_PcrG; TIGR02573 208964005169 V antigen (LcrV) protein; Region: LcrV; pfam04792 208964005170 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 208964005171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964005172 binding surface 208964005173 TPR motif; other site 208964005174 Uncharacterized conserved protein [Function unknown]; Region: COG5613 208964005175 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 208964005176 YopD protein; Region: YopD; pfam05844 208964005177 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 208964005178 type III secretion system chaperone YscW; Region: YscW; TIGR02567 208964005179 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964005180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964005181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964005182 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 208964005183 type III secretion system chaperone, YscB family; Region: type_III_yscB; TIGR02513 208964005184 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 208964005185 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964005186 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964005187 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 208964005188 type III secretion system protein SsaD; Provisional; Region: PRK15367 208964005189 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 208964005190 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 208964005191 Type III secretion needle MxiH like; Region: MxiH; pfam09392 208964005192 Bacterial type II secretion system chaperone protein (type_III_yscG); Region: Type_III_YscG; pfam09477 208964005193 YopR Core; Region: YopR_core; cl07585 208964005194 Type III secretion needle MxiH like; Region: MxiH; pfam09392 208964005195 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 208964005196 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 208964005197 type III secretion system protein; Reviewed; Region: PRK06937 208964005198 Flagellar assembly protein FliH; Region: FliH; cl19405 208964005199 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 208964005200 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 208964005201 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 208964005202 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 208964005203 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 208964005204 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 208964005205 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 208964005206 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 208964005207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964005208 metal binding site [ion binding]; metal-binding site 208964005209 active site 208964005210 I-site; other site 208964005211 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964005212 Regulator of ribonuclease activity B; Region: RraB; pfam06877 208964005213 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 208964005214 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 208964005215 catalytic triad [active] 208964005216 Uncharacterized conserved protein [Function unknown]; Region: COG2308 208964005217 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 208964005218 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 208964005219 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 208964005220 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 208964005221 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 208964005222 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964005223 Cytochrome c; Region: Cytochrom_C; pfam00034 208964005224 Predicted permeases [General function prediction only]; Region: COG0679 208964005225 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 208964005226 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964005227 dimer interface [polypeptide binding]; other site 208964005228 active site 208964005229 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 208964005230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964005231 substrate binding site [chemical binding]; other site 208964005232 oxyanion hole (OAH) forming residues; other site 208964005233 trimer interface [polypeptide binding]; other site 208964005234 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 208964005235 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964005236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964005237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964005238 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 208964005239 putative effector binding pocket; other site 208964005240 putative dimerization interface [polypeptide binding]; other site 208964005241 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208964005242 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 208964005243 active site 208964005244 catalytic tetrad [active] 208964005245 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 208964005246 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 208964005247 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 208964005248 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 208964005249 catalytic triad [active] 208964005250 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 208964005251 ADP-ribose binding site [chemical binding]; other site 208964005252 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 208964005253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964005254 substrate binding site [chemical binding]; other site 208964005255 oxyanion hole (OAH) forming residues; other site 208964005256 trimer interface [polypeptide binding]; other site 208964005257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964005258 Coenzyme A binding pocket [chemical binding]; other site 208964005259 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 208964005260 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 208964005261 catalytic residues [active] 208964005262 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 208964005263 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 208964005264 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 208964005265 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964005266 Ligand Binding Site [chemical binding]; other site 208964005267 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 208964005268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964005269 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 208964005270 substrate binding site [chemical binding]; other site 208964005271 dimerization interface [polypeptide binding]; other site 208964005272 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 208964005273 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 208964005274 Active Sites [active] 208964005275 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 208964005276 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 208964005277 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 208964005278 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 208964005279 chorismate binding enzyme; Region: Chorismate_bind; cl10555 208964005280 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 208964005281 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964005282 DNA binding residues [nucleotide binding] 208964005283 dimerization interface [polypeptide binding]; other site 208964005284 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 208964005285 AAA ATPase domain; Region: AAA_16; pfam13191 208964005286 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964005287 DNA binding residues [nucleotide binding] 208964005288 dimerization interface [polypeptide binding]; other site 208964005289 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 208964005290 putative active site [active] 208964005291 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 208964005292 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 208964005293 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 208964005294 Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148 208964005295 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; cl19204 208964005296 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 208964005297 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 208964005298 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 208964005299 PEP synthetase regulatory protein; Provisional; Region: PRK05339 208964005300 phosphoenolpyruvate synthase; Validated; Region: PRK06464 208964005301 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 208964005302 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 208964005303 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 208964005304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964005305 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964005306 FIST N domain; Region: FIST; cl10701 208964005307 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 208964005308 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 208964005309 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 208964005310 Cl binding site [ion binding]; other site 208964005311 oligomer interface [polypeptide binding]; other site 208964005312 Conserved TM helix; Region: TM_helix; pfam05552 208964005313 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 208964005314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964005315 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 208964005316 DNA binding residues [nucleotide binding] 208964005317 OprF membrane domain; Region: OprF; pfam05736 208964005318 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964005319 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964005320 ligand binding site [chemical binding]; other site 208964005321 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 208964005322 active site 208964005323 SAM binding site [chemical binding]; other site 208964005324 homodimer interface [polypeptide binding]; other site 208964005325 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 208964005326 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 208964005327 [4Fe-4S] binding site [ion binding]; other site 208964005328 molybdopterin cofactor binding site; other site 208964005329 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 208964005330 molybdopterin cofactor binding site; other site 208964005331 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 208964005332 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 208964005333 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 208964005334 [2Fe-2S] cluster binding site [ion binding]; other site 208964005335 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 208964005336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964005337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964005338 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 208964005339 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 208964005340 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 208964005341 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 208964005342 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 208964005343 Protein kinase domain; Region: Pkinase; pfam00069 208964005344 Catalytic domain of Protein Kinases; Region: PKc; cd00180 208964005345 active site 208964005346 ATP binding site [chemical binding]; other site 208964005347 substrate binding site [chemical binding]; other site 208964005348 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 208964005349 substrate binding site [chemical binding]; other site 208964005350 activation loop (A-loop); other site 208964005351 activation loop (A-loop); other site 208964005352 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 208964005353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964005354 putative substrate translocation pore; other site 208964005355 Alginate lyase; Region: Alginate_lyase2; pfam08787 208964005356 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 208964005357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964005358 active site 208964005359 phosphorylation site [posttranslational modification] 208964005360 intermolecular recognition site; other site 208964005361 dimerization interface [polypeptide binding]; other site 208964005362 ANTAR domain; Region: ANTAR; pfam03861 208964005363 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 208964005364 NMT1-like family; Region: NMT1_2; pfam13379 208964005365 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 208964005366 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 208964005367 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 208964005368 substrate binding site [chemical binding]; other site 208964005369 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 208964005370 substrate binding site [chemical binding]; other site 208964005371 ligand binding site [chemical binding]; other site 208964005372 Predicted Fe-S protein [General function prediction only]; Region: COG3313 208964005373 universal stress protein UspE; Provisional; Region: PRK11175 208964005374 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964005375 Ligand Binding Site [chemical binding]; other site 208964005376 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964005377 Ligand Binding Site [chemical binding]; other site 208964005378 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 208964005379 active site 208964005380 dinuclear metal binding site [ion binding]; other site 208964005381 dimerization interface [polypeptide binding]; other site 208964005382 SPFH domain / Band 7 family; Region: Band_7; pfam01145 208964005383 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 208964005384 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 208964005385 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 208964005386 putative active site [active] 208964005387 putative metal binding site [ion binding]; other site 208964005388 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 208964005389 substrate binding site [chemical binding]; other site 208964005390 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 208964005391 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 208964005392 active site 208964005393 HIGH motif; other site 208964005394 KMSKS motif; other site 208964005395 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 208964005396 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 208964005397 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 208964005398 active site 208964005399 HIGH motif; other site 208964005400 KMSKS motif; other site 208964005401 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 208964005402 tRNA binding surface [nucleotide binding]; other site 208964005403 anticodon binding site; other site 208964005404 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 208964005405 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 208964005406 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 208964005407 homodimer interface [polypeptide binding]; other site 208964005408 NADP binding site [chemical binding]; other site 208964005409 substrate binding site [chemical binding]; other site 208964005410 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 208964005411 Beta-lactamase; Region: Beta-lactamase; pfam00144 208964005412 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964005413 dimerization interface [polypeptide binding]; other site 208964005414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964005415 dimer interface [polypeptide binding]; other site 208964005416 phosphorylation site [posttranslational modification] 208964005417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964005418 ATP binding site [chemical binding]; other site 208964005419 Mg2+ binding site [ion binding]; other site 208964005420 G-X-G motif; other site 208964005421 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 208964005422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964005423 active site 208964005424 phosphorylation site [posttranslational modification] 208964005425 intermolecular recognition site; other site 208964005426 dimerization interface [polypeptide binding]; other site 208964005427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964005428 DNA binding site [nucleotide binding] 208964005429 trigger factor; Provisional; Region: tig; PRK01490 208964005430 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 208964005431 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 208964005432 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 208964005433 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 208964005434 oligomer interface [polypeptide binding]; other site 208964005435 active site residues [active] 208964005436 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 208964005437 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 208964005438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964005439 Walker A motif; other site 208964005440 ATP binding site [chemical binding]; other site 208964005441 Walker B motif; other site 208964005442 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 208964005443 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 208964005444 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 208964005445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964005446 Walker A motif; other site 208964005447 ATP binding site [chemical binding]; other site 208964005448 Walker B motif; other site 208964005449 arginine finger; other site 208964005450 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 208964005451 histone-like DNA-binding protein HU; Region: HU; cd13831 208964005452 dimer interface [polypeptide binding]; other site 208964005453 DNA binding site [nucleotide binding] 208964005454 periplasmic folding chaperone; Provisional; Region: PRK10788 208964005455 SurA N-terminal domain; Region: SurA_N_3; pfam13624 208964005456 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 208964005457 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 208964005458 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 208964005459 NAD binding site [chemical binding]; other site 208964005460 homotetramer interface [polypeptide binding]; other site 208964005461 homodimer interface [polypeptide binding]; other site 208964005462 substrate binding site [chemical binding]; other site 208964005463 active site 208964005464 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 208964005465 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208964005466 Walker A/P-loop; other site 208964005467 ATP binding site [chemical binding]; other site 208964005468 Q-loop/lid; other site 208964005469 ABC transporter signature motif; other site 208964005470 Walker B; other site 208964005471 D-loop; other site 208964005472 H-loop/switch region; other site 208964005473 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208964005474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208964005475 Walker A/P-loop; other site 208964005476 ATP binding site [chemical binding]; other site 208964005477 Q-loop/lid; other site 208964005478 ABC transporter signature motif; other site 208964005479 Walker B; other site 208964005480 D-loop; other site 208964005481 H-loop/switch region; other site 208964005482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208964005483 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 208964005484 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 208964005485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964005486 dimer interface [polypeptide binding]; other site 208964005487 conserved gate region; other site 208964005488 putative PBP binding loops; other site 208964005489 ABC-ATPase subunit interface; other site 208964005490 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 208964005491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964005492 dimer interface [polypeptide binding]; other site 208964005493 conserved gate region; other site 208964005494 putative PBP binding loops; other site 208964005495 ABC-ATPase subunit interface; other site 208964005496 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208964005497 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 208964005498 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208964005499 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 208964005500 MltD lipid attachment motif; Region: MLTD_N; pfam06474 208964005501 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 208964005502 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964005503 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964005504 catalytic residue [active] 208964005505 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964005506 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964005507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964005508 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 208964005509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 208964005510 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 208964005511 RNA/DNA hybrid binding site [nucleotide binding]; other site 208964005512 active site 208964005513 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 208964005514 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 208964005515 active site 208964005516 catalytic site [active] 208964005517 substrate binding site [chemical binding]; other site 208964005518 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 208964005519 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 208964005520 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 208964005521 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 208964005522 homodimer interface [polypeptide binding]; other site 208964005523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964005524 catalytic residue [active] 208964005525 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 208964005526 arginine:agmatin antiporter; Provisional; Region: PRK10644 208964005527 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 208964005528 enoyl-CoA hydratase; Provisional; Region: PRK06142 208964005529 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964005530 substrate binding site [chemical binding]; other site 208964005531 oxyanion hole (OAH) forming residues; other site 208964005532 trimer interface [polypeptide binding]; other site 208964005533 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 208964005534 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 208964005535 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 208964005536 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 208964005537 putative NADH binding site [chemical binding]; other site 208964005538 putative active site [active] 208964005539 nudix motif; other site 208964005540 putative metal binding site [ion binding]; other site 208964005541 hypothetical protein; Provisional; Region: PRK10621 208964005542 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 208964005543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964005544 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 208964005545 dimerization interface [polypeptide binding]; other site 208964005546 substrate binding pocket [chemical binding]; other site 208964005547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208964005548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964005549 NAD(P) binding site [chemical binding]; other site 208964005550 active site 208964005551 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 208964005552 classical (c) SDRs; Region: SDR_c; cd05233 208964005553 NAD(P) binding site [chemical binding]; other site 208964005554 active site 208964005555 Phosphotransferase enzyme family; Region: APH; pfam01636 208964005556 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 208964005557 putative active site [active] 208964005558 putative substrate binding site [chemical binding]; other site 208964005559 ATP binding site [chemical binding]; other site 208964005560 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 208964005561 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 208964005562 catalytic core [active] 208964005563 Tyrosine phosphatase family; Region: Y_phosphatase3; cl19170 208964005564 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 208964005565 putative inner membrane peptidase; Provisional; Region: PRK11778 208964005566 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 208964005567 tandem repeat interface [polypeptide binding]; other site 208964005568 oligomer interface [polypeptide binding]; other site 208964005569 active site residues [active] 208964005570 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 208964005571 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 208964005572 NADP binding site [chemical binding]; other site 208964005573 dimer interface [polypeptide binding]; other site 208964005574 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 208964005575 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964005576 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964005577 CoenzymeA binding site [chemical binding]; other site 208964005578 subunit interaction site [polypeptide binding]; other site 208964005579 PHB binding site; other site 208964005580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964005581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964005582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 208964005583 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 208964005584 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 208964005585 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 208964005586 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 208964005587 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 208964005588 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 208964005589 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 208964005590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964005591 FeS/SAM binding site; other site 208964005592 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 208964005593 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 208964005594 putative deacylase active site [active] 208964005595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3171 208964005596 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 208964005597 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 208964005598 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 208964005599 substrate binding pocket [chemical binding]; other site 208964005600 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 208964005601 B12 binding site [chemical binding]; other site 208964005602 cobalt ligand [ion binding]; other site 208964005603 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 208964005604 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 208964005605 Cytochrome c; Region: Cytochrom_C; cl11414 208964005606 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 208964005607 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 208964005608 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 208964005609 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 208964005610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964005611 putative substrate translocation pore; other site 208964005612 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964005613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 208964005614 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 208964005615 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 208964005616 conserved cys residue [active] 208964005617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964005618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964005619 metal binding site [ion binding]; metal-binding site 208964005620 active site 208964005621 I-site; other site 208964005622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964005623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964005624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964005625 dimerization interface [polypeptide binding]; other site 208964005626 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 208964005627 HPP family; Region: HPP; pfam04982 208964005628 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 208964005629 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 208964005630 Low-spin heme binding site [chemical binding]; other site 208964005631 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 208964005632 D-pathway; other site 208964005633 Putative water exit pathway; other site 208964005634 Binuclear center (active site) [active] 208964005635 K-pathway; other site 208964005636 Putative proton exit pathway; other site 208964005637 Protein of unknown function (DUF808); Region: DUF808; pfam05661 208964005638 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 208964005639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964005640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964005641 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 208964005642 putative effector binding pocket; other site 208964005643 dimerization interface [polypeptide binding]; other site 208964005644 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 208964005645 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 208964005646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964005647 Walker A/P-loop; other site 208964005648 ATP binding site [chemical binding]; other site 208964005649 Q-loop/lid; other site 208964005650 ABC transporter signature motif; other site 208964005651 Walker B; other site 208964005652 D-loop; other site 208964005653 H-loop/switch region; other site 208964005654 TOBE domain; Region: TOBE; cl01440 208964005655 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 208964005656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964005657 dimer interface [polypeptide binding]; other site 208964005658 conserved gate region; other site 208964005659 putative PBP binding loops; other site 208964005660 ABC-ATPase subunit interface; other site 208964005661 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 208964005662 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 208964005663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964005664 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 208964005665 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 208964005666 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 208964005667 DEAD_2; Region: DEAD_2; pfam06733 208964005668 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 208964005669 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 208964005670 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 208964005671 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964005672 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964005673 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964005674 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 208964005675 acyl carrier protein; Provisional; Region: acpP; PRK00982 208964005676 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208964005677 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964005678 EcsC protein family; Region: EcsC; pfam12787 208964005679 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 208964005680 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 208964005681 Cl binding site [ion binding]; other site 208964005682 oligomer interface [polypeptide binding]; other site 208964005683 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 208964005684 Herpes virus major outer envelope glycoprotein (BLLF1); Region: Herpes_BLLF1; pfam05109 208964005685 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 208964005686 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 208964005687 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 208964005688 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 208964005689 Outer membrane efflux protein; Region: OEP; pfam02321 208964005690 Outer membrane efflux protein; Region: OEP; pfam02321 208964005691 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 208964005692 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 208964005693 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208964005694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964005695 Walker A/P-loop; other site 208964005696 ATP binding site [chemical binding]; other site 208964005697 Q-loop/lid; other site 208964005698 ABC transporter signature motif; other site 208964005699 Walker B; other site 208964005700 D-loop; other site 208964005701 H-loop/switch region; other site 208964005702 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 208964005703 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964005704 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964005705 HD domain; Region: HD_3; pfam13023 208964005706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964005707 non-specific DNA binding site [nucleotide binding]; other site 208964005708 salt bridge; other site 208964005709 sequence-specific DNA binding site [nucleotide binding]; other site 208964005710 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964005711 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 208964005712 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 208964005713 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964005714 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 208964005715 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964005716 catalytic loop [active] 208964005717 iron binding site [ion binding]; other site 208964005718 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 208964005719 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 208964005720 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 208964005721 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208964005722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964005723 non-specific DNA binding site [nucleotide binding]; other site 208964005724 salt bridge; other site 208964005725 sequence-specific DNA binding site [nucleotide binding]; other site 208964005726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 208964005727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964005728 Coenzyme A binding pocket [chemical binding]; other site 208964005729 DNA polymerase II; Reviewed; Region: PRK05762 208964005730 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 208964005731 active site 208964005732 catalytic site [active] 208964005733 substrate binding site [chemical binding]; other site 208964005734 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 208964005735 active site 208964005736 metal-binding site 208964005737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964005738 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964005739 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 208964005740 putative C-terminal domain interface [polypeptide binding]; other site 208964005741 putative GSH binding site (G-site) [chemical binding]; other site 208964005742 putative dimer interface [polypeptide binding]; other site 208964005743 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 208964005744 putative N-terminal domain interface [polypeptide binding]; other site 208964005745 putative dimer interface [polypeptide binding]; other site 208964005746 putative substrate binding pocket (H-site) [chemical binding]; other site 208964005747 Penicillin amidase; Region: Penicil_amidase; pfam01804 208964005748 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 208964005749 active site 208964005750 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 208964005751 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 208964005752 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 208964005753 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 208964005754 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 208964005755 Autoinducer binding domain; Region: Autoind_bind; pfam03472 208964005756 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964005757 DNA binding residues [nucleotide binding] 208964005758 dimerization interface [polypeptide binding]; other site 208964005759 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 208964005760 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 208964005761 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 208964005762 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 208964005763 hydrophobic substrate binding pocket; other site 208964005764 active site 208964005765 conserved cis-peptide bond; other site 208964005766 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 208964005767 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 208964005768 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 208964005769 Glutamine amidotransferase class-I; Region: GATase; pfam00117 208964005770 glutamine binding [chemical binding]; other site 208964005771 catalytic triad [active] 208964005772 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 208964005773 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 208964005774 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 208964005775 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 208964005776 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 208964005777 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 208964005778 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 208964005779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964005780 putative substrate translocation pore; other site 208964005781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964005782 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 208964005783 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 208964005784 RNA polymerase Rpb5, C-terminal domain; Region: RNA_pol_Rpb5_C; cl00883 208964005785 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 208964005786 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964005787 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 208964005788 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964005789 N-terminal plug; other site 208964005790 ligand-binding site [chemical binding]; other site 208964005791 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964005792 FecR protein; Region: FecR; pfam04773 208964005793 RNA polymerase sigma factor; Provisional; Region: PRK12528 208964005794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964005795 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964005796 DNA binding residues [nucleotide binding] 208964005797 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 208964005798 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 208964005799 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 208964005800 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 208964005801 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 208964005802 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 208964005803 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 208964005804 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964005805 FAD dependent oxidoreductase; Region: DAO; pfam01266 208964005806 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 208964005807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964005808 FeS/SAM binding site; other site 208964005809 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 208964005810 ATP cone domain; Region: ATP-cone; pfam03477 208964005811 Class III ribonucleotide reductase; Region: RNR_III; cd01675 208964005812 effector binding site; other site 208964005813 active site 208964005814 Zn binding site [ion binding]; other site 208964005815 glycine loop; other site 208964005816 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964005817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964005818 S-adenosylmethionine binding site [chemical binding]; other site 208964005819 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 208964005820 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964005821 N-terminal plug; other site 208964005822 ligand-binding site [chemical binding]; other site 208964005823 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 208964005824 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 208964005825 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 208964005826 Uncharacterized conserved protein [Function unknown]; Region: COG4744 208964005827 Uncharacterized conserved protein [Function unknown]; Region: COG1944 208964005828 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 208964005829 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 208964005830 THF binding site; other site 208964005831 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 208964005832 substrate binding site [chemical binding]; other site 208964005833 THF binding site; other site 208964005834 zinc-binding site [ion binding]; other site 208964005835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208964005836 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 208964005837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964005838 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 208964005839 putative active site [active] 208964005840 heme pocket [chemical binding]; other site 208964005841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964005842 putative active site [active] 208964005843 heme pocket [chemical binding]; other site 208964005844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 208964005845 dimer interface [polypeptide binding]; other site 208964005846 putative CheW interface [polypeptide binding]; other site 208964005847 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 208964005848 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 208964005849 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 208964005850 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 208964005851 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 208964005852 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 208964005853 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 208964005854 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 208964005855 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964005856 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 208964005857 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 208964005858 Transposase; Region: HTH_Tnp_1; pfam01527 208964005859 putative transposase OrfB; Reviewed; Region: PHA02517 208964005860 HTH-like domain; Region: HTH_21; pfam13276 208964005861 Integrase core domain; Region: rve; pfam00665 208964005862 Integrase core domain; Region: rve_3; pfam13683 208964005863 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 208964005864 AAA domain; Region: AAA_21; pfam13304 208964005865 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 208964005866 putative active site [active] 208964005867 putative metal-binding site [ion binding]; other site 208964005868 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 208964005869 putative heme binding pocket [chemical binding]; other site 208964005870 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208964005871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964005872 Coenzyme A binding pocket [chemical binding]; other site 208964005873 Peptidase_C39 like family; Region: DUF3335; pfam11814 208964005874 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 208964005875 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 208964005876 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964005877 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964005878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964005879 Walker A motif; other site 208964005880 ATP binding site [chemical binding]; other site 208964005881 Walker B motif; other site 208964005882 arginine finger; other site 208964005883 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964005884 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 208964005885 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 208964005886 ligand binding site [chemical binding]; other site 208964005887 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 208964005888 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 208964005889 Walker A/P-loop; other site 208964005890 ATP binding site [chemical binding]; other site 208964005891 Q-loop/lid; other site 208964005892 ABC transporter signature motif; other site 208964005893 Walker B; other site 208964005894 D-loop; other site 208964005895 H-loop/switch region; other site 208964005896 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 208964005897 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 208964005898 TM-ABC transporter signature motif; other site 208964005899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208964005900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208964005901 DNA binding site [nucleotide binding] 208964005902 domain linker motif; other site 208964005903 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 208964005904 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 208964005905 substrate binding site [chemical binding]; other site 208964005906 dimer interface [polypeptide binding]; other site 208964005907 ATP binding site [chemical binding]; other site 208964005908 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 208964005909 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 208964005910 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 208964005911 putative active site [active] 208964005912 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 208964005913 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 208964005914 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 208964005915 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208964005916 DNA-binding site [nucleotide binding]; DNA binding site 208964005917 RNA-binding motif; other site 208964005918 Predicted membrane protein [Function unknown]; Region: COG3326 208964005919 LysR family transcriptional regulator; Provisional; Region: PRK14997 208964005920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964005921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964005922 dimerization interface [polypeptide binding]; other site 208964005923 azoreductase; Reviewed; Region: PRK00170 208964005924 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 208964005925 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964005926 ABC transporter; Region: ABC_tran_2; pfam12848 208964005927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964005928 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 208964005929 putative substrate binding pocket [chemical binding]; other site 208964005930 trimer interface [polypeptide binding]; other site 208964005931 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 208964005932 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 208964005933 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 208964005934 putative metal dependent hydrolase; Provisional; Region: PRK11598 208964005935 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 208964005936 Sulfatase; Region: Sulfatase; pfam00884 208964005937 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 208964005938 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 208964005939 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 208964005940 Gram-negative porin; Region: Porin_4; pfam13609 208964005941 Uncharacterized conserved protein [Function unknown]; Region: COG3287 208964005942 FIST N domain; Region: FIST; pfam08495 208964005943 FIST C domain; Region: FIST_C; pfam10442 208964005944 PAS fold; Region: PAS_7; pfam12860 208964005945 PAS fold; Region: PAS_7; pfam12860 208964005946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964005947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964005948 dimer interface [polypeptide binding]; other site 208964005949 phosphorylation site [posttranslational modification] 208964005950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964005951 ATP binding site [chemical binding]; other site 208964005952 Mg2+ binding site [ion binding]; other site 208964005953 G-X-G motif; other site 208964005954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964005955 active site 208964005956 phosphorylation site [posttranslational modification] 208964005957 intermolecular recognition site; other site 208964005958 dimerization interface [polypeptide binding]; other site 208964005959 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964005960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964005961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964005962 active site 208964005963 intermolecular recognition site; other site 208964005964 dimerization interface [polypeptide binding]; other site 208964005965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964005966 DNA binding residues [nucleotide binding] 208964005967 dimerization interface [polypeptide binding]; other site 208964005968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 208964005969 Histidine kinase; Region: HisKA_3; pfam07730 208964005970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964005971 ATP binding site [chemical binding]; other site 208964005972 Mg2+ binding site [ion binding]; other site 208964005973 G-X-G motif; other site 208964005974 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964005975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964005976 active site 208964005977 phosphorylation site [posttranslational modification] 208964005978 intermolecular recognition site; other site 208964005979 dimerization interface [polypeptide binding]; other site 208964005980 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964005981 DNA binding residues [nucleotide binding] 208964005982 dimerization interface [polypeptide binding]; other site 208964005983 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 208964005984 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 208964005985 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 208964005986 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 208964005987 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 208964005988 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 208964005989 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 208964005990 dimer interface [polypeptide binding]; other site 208964005991 Trp docking motif [polypeptide binding]; other site 208964005992 active site 208964005993 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964005994 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 208964005995 NAD(P) binding site [chemical binding]; other site 208964005996 catalytic residues [active] 208964005997 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 208964005998 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 208964005999 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 208964006000 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 208964006001 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 208964006002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964006003 FeS/SAM binding site; other site 208964006004 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 208964006005 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 208964006006 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 208964006007 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 208964006008 putative active site [active] 208964006009 metal binding site [ion binding]; metal-binding site 208964006010 PAS domain S-box; Region: sensory_box; TIGR00229 208964006011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964006012 putative active site [active] 208964006013 heme pocket [chemical binding]; other site 208964006014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964006015 dimer interface [polypeptide binding]; other site 208964006016 phosphorylation site [posttranslational modification] 208964006017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964006018 ATP binding site [chemical binding]; other site 208964006019 Mg2+ binding site [ion binding]; other site 208964006020 G-X-G motif; other site 208964006021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964006022 active site 208964006023 phosphorylation site [posttranslational modification] 208964006024 intermolecular recognition site; other site 208964006025 dimerization interface [polypeptide binding]; other site 208964006026 major facilitator superfamily transporter; Provisional; Region: PRK05122 208964006027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006028 putative substrate translocation pore; other site 208964006029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 208964006030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 208964006031 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 208964006032 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 208964006033 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 208964006034 acyl-activating enzyme (AAE) consensus motif; other site 208964006035 putative AMP binding site [chemical binding]; other site 208964006036 putative active site [active] 208964006037 putative CoA binding site [chemical binding]; other site 208964006038 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006040 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 208964006041 putative dimerization interface [polypeptide binding]; other site 208964006042 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 208964006043 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 208964006044 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 208964006045 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964006046 dimer interface [polypeptide binding]; other site 208964006047 active site 208964006048 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 208964006049 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 208964006050 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 208964006051 NAD binding site [chemical binding]; other site 208964006052 homotetramer interface [polypeptide binding]; other site 208964006053 homodimer interface [polypeptide binding]; other site 208964006054 substrate binding site [chemical binding]; other site 208964006055 active site 208964006056 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 208964006057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964006058 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 208964006059 putative active site [active] 208964006060 heme pocket [chemical binding]; other site 208964006061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964006062 Walker A motif; other site 208964006063 ATP binding site [chemical binding]; other site 208964006064 Walker B motif; other site 208964006065 arginine finger; other site 208964006066 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964006067 benzoate transport; Region: 2A0115; TIGR00895 208964006068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006069 putative substrate translocation pore; other site 208964006070 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 208964006071 maleylacetoacetate isomerase; Region: maiA; TIGR01262 208964006072 C-terminal domain interface [polypeptide binding]; other site 208964006073 GSH binding site (G-site) [chemical binding]; other site 208964006074 putative dimer interface [polypeptide binding]; other site 208964006075 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 208964006076 dimer interface [polypeptide binding]; other site 208964006077 N-terminal domain interface [polypeptide binding]; other site 208964006078 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 208964006079 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 208964006080 Fumarylacetoacetase N-terminal; Region: FAA_hydrolase_N; pfam09298 208964006081 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 208964006082 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 208964006083 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 208964006084 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208964006085 Bacterial transcriptional regulator; Region: IclR; pfam01614 208964006086 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 208964006087 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 208964006088 active site 208964006089 catalytic residues [active] 208964006090 metal binding site [ion binding]; metal-binding site 208964006091 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 208964006092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208964006093 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964006094 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 208964006095 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208964006096 carboxyltransferase (CT) interaction site; other site 208964006097 biotinylation site [posttranslational modification]; other site 208964006098 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 208964006099 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964006100 substrate binding site [chemical binding]; other site 208964006101 oxyanion hole (OAH) forming residues; other site 208964006102 trimer interface [polypeptide binding]; other site 208964006103 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 208964006104 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 208964006105 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 208964006106 isovaleryl-CoA dehydrogenase; Region: PLN02519 208964006107 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 208964006108 substrate binding site [chemical binding]; other site 208964006109 FAD binding site [chemical binding]; other site 208964006110 catalytic base [active] 208964006111 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 208964006112 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 208964006113 DNA binding residues [nucleotide binding] 208964006114 putative dimer interface [polypeptide binding]; other site 208964006115 SdiA-regulated; Region: SdiA-regulated; cd09971 208964006116 putative active site [active] 208964006117 multidrug efflux protein; Reviewed; Region: PRK09577 208964006118 MMPL family; Region: MMPL; cl14618 208964006119 MMPL family; Region: MMPL; cl14618 208964006120 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 208964006121 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964006122 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964006123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964006124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964006125 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 208964006126 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 208964006127 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 208964006128 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 208964006129 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 208964006130 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 208964006131 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 208964006132 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 208964006133 active site 208964006134 tetramer interface; other site 208964006135 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 208964006136 active site 208964006137 metal binding site [ion binding]; metal-binding site 208964006138 glutathione reductase; Validated; Region: PRK06116 208964006139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964006140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964006141 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 208964006142 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 208964006143 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964006144 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964006145 putative DNA binding site [nucleotide binding]; other site 208964006146 putative Zn2+ binding site [ion binding]; other site 208964006147 AsnC family; Region: AsnC_trans_reg; pfam01037 208964006148 Winged helix-turn helix; Region: HTH_43; pfam09904 208964006149 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 208964006150 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 208964006151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964006152 DNA-binding site [nucleotide binding]; DNA binding site 208964006153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964006154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964006155 homodimer interface [polypeptide binding]; other site 208964006156 catalytic residue [active] 208964006157 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 208964006158 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 208964006159 FAD binding pocket [chemical binding]; other site 208964006160 FAD binding motif [chemical binding]; other site 208964006161 phosphate binding motif [ion binding]; other site 208964006162 NAD binding pocket [chemical binding]; other site 208964006163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964006164 S-adenosylmethionine binding site [chemical binding]; other site 208964006165 thiamine pyrophosphate protein; Validated; Region: PRK08199 208964006166 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 208964006167 PYR/PP interface [polypeptide binding]; other site 208964006168 dimer interface [polypeptide binding]; other site 208964006169 TPP binding site [chemical binding]; other site 208964006170 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964006171 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 208964006172 TPP-binding site [chemical binding]; other site 208964006173 Methyltransferase domain; Region: Methyltransf_23; pfam13489 208964006174 Predicted membrane protein [Function unknown]; Region: COG4392 208964006175 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 208964006176 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208964006177 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 208964006178 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208964006179 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208964006180 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964006181 serine/threonine transporter SstT; Provisional; Region: PRK13628 208964006182 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 208964006183 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 208964006184 probable active site [active] 208964006185 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 208964006186 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 208964006187 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 208964006188 Haemolytic domain; Region: Haemolytic; pfam01809 208964006189 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 208964006190 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964006191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964006192 Uncharacterized conserved protein [Function unknown]; Region: COG1359 208964006193 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 208964006194 putative active site [active] 208964006195 putative metal binding site [ion binding]; other site 208964006196 RNA polymerase sigma factor; Provisional; Region: PRK12525 208964006197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964006198 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964006199 DNA binding residues [nucleotide binding] 208964006200 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964006201 FecR protein; Region: FecR; pfam04773 208964006202 cyanate hydratase; Validated; Region: PRK02866 208964006203 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 208964006204 oligomer interface [polypeptide binding]; other site 208964006205 active site 208964006206 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 208964006207 active site clefts [active] 208964006208 zinc binding site [ion binding]; other site 208964006209 dimer interface [polypeptide binding]; other site 208964006210 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 208964006211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964006213 dimerization interface [polypeptide binding]; other site 208964006214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964006216 putative substrate translocation pore; other site 208964006217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006219 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964006220 putative effector binding pocket; other site 208964006221 dimerization interface [polypeptide binding]; other site 208964006222 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 208964006223 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 208964006224 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208964006225 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 208964006226 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 208964006227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964006228 dimer interface [polypeptide binding]; other site 208964006229 conserved gate region; other site 208964006230 putative PBP binding loops; other site 208964006231 ABC-ATPase subunit interface; other site 208964006232 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 208964006233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964006234 dimer interface [polypeptide binding]; other site 208964006235 conserved gate region; other site 208964006236 putative PBP binding loops; other site 208964006237 ABC-ATPase subunit interface; other site 208964006238 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 208964006239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208964006240 Walker A/P-loop; other site 208964006241 ATP binding site [chemical binding]; other site 208964006242 Q-loop/lid; other site 208964006243 ABC transporter signature motif; other site 208964006244 Walker B; other site 208964006245 D-loop; other site 208964006246 H-loop/switch region; other site 208964006247 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208964006248 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208964006249 Walker A/P-loop; other site 208964006250 ATP binding site [chemical binding]; other site 208964006251 Q-loop/lid; other site 208964006252 ABC transporter signature motif; other site 208964006253 Walker B; other site 208964006254 D-loop; other site 208964006255 H-loop/switch region; other site 208964006256 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208964006257 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 208964006258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964006259 catalytic residue [active] 208964006260 Uncharacterized conserved protein [Function unknown]; Region: COG3673 208964006261 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: PcoB; COG3667 208964006262 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 208964006263 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 208964006264 The first cupredoxin domain of CopA copper resistance protein family; Region: CuRO_1_CopA; cd13848 208964006265 putative Domain 2 interface [polypeptide binding]; other site 208964006266 putative Domain 3 interface [polypeptide binding]; other site 208964006267 trinuclear Cu binding site [ion binding]; other site 208964006268 The second cupredoxin domain of CopA copper resistance protein family; Region: CuRO_2_CopA; cd13874 208964006269 putative Domain 1 interface [polypeptide binding]; other site 208964006270 putative Domain 3 interface [polypeptide binding]; other site 208964006271 Forkhead N-terminal region; Region: Fork_head_N; pfam08430 208964006272 The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896 208964006273 putative Domain 2 interface [polypeptide binding]; other site 208964006274 Type 1 (T1) Cu binding site [ion binding]; other site 208964006275 putative Domain 1 interface [polypeptide binding]; other site 208964006276 trinuclear Cu binding site [ion binding]; other site 208964006277 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 208964006278 putative active site [active] 208964006279 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 208964006280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964006281 motif II; other site 208964006282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006283 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964006284 putative substrate translocation pore; other site 208964006285 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 208964006286 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964006287 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964006288 N-terminal plug; other site 208964006289 ligand-binding site [chemical binding]; other site 208964006290 elongation factor G; Reviewed; Region: PRK00007 208964006291 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 208964006292 G1 box; other site 208964006293 putative GEF interaction site [polypeptide binding]; other site 208964006294 GTP/Mg2+ binding site [chemical binding]; other site 208964006295 Switch I region; other site 208964006296 G2 box; other site 208964006297 G3 box; other site 208964006298 Switch II region; other site 208964006299 G4 box; other site 208964006300 G5 box; other site 208964006301 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 208964006302 Elongation Factor G, domain II; Region: EFG_II; pfam14492 208964006303 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 208964006304 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 208964006305 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 208964006306 PAS domain S-box; Region: sensory_box; TIGR00229 208964006307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964006308 putative active site [active] 208964006309 heme pocket [chemical binding]; other site 208964006310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964006311 metal binding site [ion binding]; metal-binding site 208964006312 active site 208964006313 I-site; other site 208964006314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964006315 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 208964006316 Na binding site [ion binding]; other site 208964006317 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 208964006318 putative active site [active] 208964006319 catalytic triad [active] 208964006320 putative dimer interface [polypeptide binding]; other site 208964006321 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 208964006322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006324 LysR substrate binding domain; Region: LysR_substrate; pfam03466 208964006325 dimerization interface [polypeptide binding]; other site 208964006326 Cytochrome c; Region: Cytochrom_C; pfam00034 208964006327 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 208964006328 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 208964006329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964006330 catalytic residue [active] 208964006331 arylformamidase; Region: trp_arylform; TIGR03035 208964006332 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964006333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964006334 putative DNA binding site [nucleotide binding]; other site 208964006335 putative Zn2+ binding site [ion binding]; other site 208964006336 AsnC family; Region: AsnC_trans_reg; pfam01037 208964006337 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 208964006338 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 208964006339 [2Fe-2S] cluster binding site [ion binding]; other site 208964006340 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 208964006341 putative alpha subunit interface [polypeptide binding]; other site 208964006342 putative active site [active] 208964006343 putative substrate binding site [chemical binding]; other site 208964006344 Fe binding site [ion binding]; other site 208964006345 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 208964006346 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 208964006347 active site 208964006348 dimer interface [polypeptide binding]; other site 208964006349 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 208964006350 Ligand Binding Site [chemical binding]; other site 208964006351 Molecular Tunnel; other site 208964006352 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 208964006353 inter-subunit interface; other site 208964006354 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964006355 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964006356 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964006357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964006358 S-adenosylmethionine binding site [chemical binding]; other site 208964006359 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964006360 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964006361 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964006362 N-terminal plug; other site 208964006363 ligand-binding site [chemical binding]; other site 208964006364 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 208964006365 dimer interface [polypeptide binding]; other site 208964006366 active site 208964006367 non-prolyl cis peptide bond; other site 208964006368 insertion regions; other site 208964006369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006370 putative substrate translocation pore; other site 208964006371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964006372 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964006373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006374 putative substrate translocation pore; other site 208964006375 RNA polymerase sigma factor; Provisional; Region: PRK12525 208964006376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964006377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964006378 DNA binding residues [nucleotide binding] 208964006379 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964006380 FecR protein; Region: FecR; pfam04773 208964006381 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964006382 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964006383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964006384 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 208964006385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 208964006386 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964006387 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 208964006388 short chain dehydrogenase; Provisional; Region: PRK08267 208964006389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964006390 NAD(P) binding site [chemical binding]; other site 208964006391 active site 208964006392 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 208964006393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964006394 DNA-binding site [nucleotide binding]; DNA binding site 208964006395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964006396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964006397 homodimer interface [polypeptide binding]; other site 208964006398 catalytic residue [active] 208964006399 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 208964006400 EamA-like transporter family; Region: EamA; pfam00892 208964006401 EamA-like transporter family; Region: EamA; pfam00892 208964006402 Predicted metal-dependent protease of the PAD1/JAB1 superfamily [General function prediction only]; Region: COG1310 208964006403 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 208964006404 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 208964006405 ATP binding site [chemical binding]; other site 208964006406 substrate interface [chemical binding]; other site 208964006407 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 208964006408 active site residue [active] 208964006409 cysteine synthase; Region: PLN02565 208964006410 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 208964006411 dimer interface [polypeptide binding]; other site 208964006412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964006413 catalytic residue [active] 208964006414 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 208964006415 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 208964006416 trimer interface [polypeptide binding]; other site 208964006417 active site 208964006418 substrate binding site [chemical binding]; other site 208964006419 CoA binding site [chemical binding]; other site 208964006420 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 208964006421 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 208964006422 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 208964006423 dimerization interface [polypeptide binding]; other site 208964006424 thiamine pyrophosphate protein; Provisional; Region: PRK08273 208964006425 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 208964006426 PYR/PP interface [polypeptide binding]; other site 208964006427 dimer interface [polypeptide binding]; other site 208964006428 tetramer interface [polypeptide binding]; other site 208964006429 TPP binding site [chemical binding]; other site 208964006430 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964006431 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 208964006432 TPP-binding site [chemical binding]; other site 208964006433 Predicted outer membrane protein [Function unknown]; Region: COG3652 208964006434 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 208964006435 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 208964006436 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 208964006437 putative active site [active] 208964006438 outer membrane porin, OprD family; Region: OprD; pfam03573 208964006439 benzoate transport; Region: 2A0115; TIGR00895 208964006440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006441 putative substrate translocation pore; other site 208964006442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964006445 dimerization interface [polypeptide binding]; other site 208964006446 Uncharacterized conserved protein [Function unknown]; Region: COG4336 208964006447 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 208964006448 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 208964006449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964006450 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 208964006451 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 208964006452 DNA binding site [nucleotide binding] 208964006453 active site 208964006454 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 208964006455 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 208964006456 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 208964006457 tetramer interface [polypeptide binding]; other site 208964006458 catalytic Zn binding site [ion binding]; other site 208964006459 NADP binding site [chemical binding]; other site 208964006460 SnoaL-like domain; Region: SnoaL_2; pfam12680 208964006461 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 208964006462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006463 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 208964006464 substrate binding pocket [chemical binding]; other site 208964006465 dimerization interface [polypeptide binding]; other site 208964006466 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 208964006467 hydrophobic ligand binding site; other site 208964006468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006470 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964006471 putative effector binding pocket; other site 208964006472 dimerization interface [polypeptide binding]; other site 208964006473 choline dehydrogenase; Validated; Region: PRK02106 208964006474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208964006475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964006476 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 208964006477 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 208964006478 NAD(P) binding site [chemical binding]; other site 208964006479 catalytic residues [active] 208964006480 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 208964006481 ParB-like nuclease domain; Region: ParBc; pfam02195 208964006482 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 208964006483 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 208964006484 Active Sites [active] 208964006485 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 208964006486 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 208964006487 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 208964006488 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 208964006489 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 208964006490 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 208964006491 PapC N-terminal domain; Region: PapC_N; pfam13954 208964006492 Outer membrane usher protein; Region: Usher; pfam00577 208964006493 PapC C-terminal domain; Region: PapC_C; pfam13953 208964006494 Fimbrial protein; Region: Fimbrial; cl01416 208964006495 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 208964006496 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 208964006497 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 208964006498 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964006499 Predicted outer membrane protein [Function unknown]; Region: COG3652 208964006500 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 208964006501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 208964006502 active site 208964006503 phosphorylation site [posttranslational modification] 208964006504 intermolecular recognition site; other site 208964006505 dimerization interface [polypeptide binding]; other site 208964006506 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 208964006507 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 208964006508 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 208964006509 active site 208964006510 DNA binding site [nucleotide binding] 208964006511 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 208964006512 DNA binding site [nucleotide binding] 208964006513 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 208964006514 nucleotide binding site [chemical binding]; other site 208964006515 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 208964006516 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 208964006517 oxidoreductase; Provisional; Region: PRK06128 208964006518 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 208964006519 NAD binding site [chemical binding]; other site 208964006520 metal binding site [ion binding]; metal-binding site 208964006521 active site 208964006522 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 208964006523 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 208964006524 homodimer interface [polypeptide binding]; other site 208964006525 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 208964006526 active site pocket [active] 208964006527 General stress protein [General function prediction only]; Region: GsiB; COG3729 208964006528 hydroperoxidase II; Provisional; Region: katE; PRK11249 208964006529 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 208964006530 tetramer interface [polypeptide binding]; other site 208964006531 heme binding pocket [chemical binding]; other site 208964006532 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 208964006533 domain interactions; other site 208964006534 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 208964006535 MgtC family; Region: MgtC; pfam02308 208964006536 Protein of unknown function (DUF1152); Region: DUF1152; cl19851 208964006537 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 208964006538 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 208964006539 putative DNA binding site [nucleotide binding]; other site 208964006540 putative homodimer interface [polypeptide binding]; other site 208964006541 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 208964006542 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 208964006543 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 208964006544 active site 208964006545 homodimer interface [polypeptide binding]; other site 208964006546 catalytic site [active] 208964006547 acceptor binding site [chemical binding]; other site 208964006548 trehalose synthase; Region: treS_nterm; TIGR02456 208964006549 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 208964006550 active site 208964006551 catalytic site [active] 208964006552 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 208964006553 glycogen branching enzyme; Provisional; Region: PRK05402 208964006554 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 208964006555 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 208964006556 active site 208964006557 catalytic site [active] 208964006558 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 208964006559 Predicted integral membrane protein [Function unknown]; Region: COG0392 208964006560 cardiolipin synthase 2; Provisional; Region: PRK11263 208964006561 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 208964006562 putative active site [active] 208964006563 catalytic site [active] 208964006564 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 208964006565 putative active site [active] 208964006566 catalytic site [active] 208964006567 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 208964006568 putative catalytic site [active] 208964006569 putative metal binding site [ion binding]; other site 208964006570 putative phosphate binding site [ion binding]; other site 208964006571 Uncharacterized conserved protein [Function unknown]; Region: COG1801 208964006572 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 208964006573 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 208964006574 NAD binding site [chemical binding]; other site 208964006575 catalytic Zn binding site [ion binding]; other site 208964006576 structural Zn binding site [ion binding]; other site 208964006577 FOG: CBS domain [General function prediction only]; Region: COG0517 208964006578 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 208964006579 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 208964006580 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 208964006581 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 208964006582 active site 208964006583 catalytic site [active] 208964006584 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 208964006585 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 208964006586 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 208964006587 active site 208964006588 catalytic site [active] 208964006589 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 208964006590 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 208964006591 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 208964006592 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 208964006593 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 208964006594 catalytic site [active] 208964006595 active site 208964006596 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 208964006597 glycogen synthase; Provisional; Region: glgA; PRK00654 208964006598 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 208964006599 ADP-binding pocket [chemical binding]; other site 208964006600 homodimer interface [polypeptide binding]; other site 208964006601 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 208964006602 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 208964006603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208964006604 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964006605 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 208964006606 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 208964006607 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 208964006608 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 208964006609 metal binding site [ion binding]; metal-binding site 208964006610 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 208964006611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964006612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964006613 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 208964006614 putative active site [active] 208964006615 heme pocket [chemical binding]; other site 208964006616 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 208964006617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964006618 putative active site [active] 208964006619 heme pocket [chemical binding]; other site 208964006620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964006621 dimer interface [polypeptide binding]; other site 208964006622 phosphorylation site [posttranslational modification] 208964006623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964006624 ATP binding site [chemical binding]; other site 208964006625 Mg2+ binding site [ion binding]; other site 208964006626 G-X-G motif; other site 208964006627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964006628 active site 208964006629 phosphorylation site [posttranslational modification] 208964006630 intermolecular recognition site; other site 208964006631 dimerization interface [polypeptide binding]; other site 208964006632 Yip1 domain; Region: Yip1; pfam04893 208964006633 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 208964006634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964006635 S-adenosylmethionine binding site [chemical binding]; other site 208964006636 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 208964006637 carboxylate-amine ligase; Provisional; Region: PRK13515 208964006638 Predicted membrane protein [Function unknown]; Region: COG3205 208964006639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 208964006640 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 208964006641 dimanganese center [ion binding]; other site 208964006642 Low affinity iron permease; Region: Iron_permease; pfam04120 208964006643 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 208964006644 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 208964006645 NAD binding site [chemical binding]; other site 208964006646 catalytic Zn binding site [ion binding]; other site 208964006647 structural Zn binding site [ion binding]; other site 208964006648 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 208964006649 active site 208964006650 General stress protein [General function prediction only]; Region: GsiB; COG3729 208964006651 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 208964006652 FOG: CBS domain [General function prediction only]; Region: COG0517 208964006653 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 208964006654 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964006655 catalytic loop [active] 208964006656 iron binding site [ion binding]; other site 208964006657 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 208964006658 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 208964006659 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964006660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964006661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964006662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964006663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964006664 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 208964006665 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 208964006666 Prostaglandin dehydrogenases; Region: PGDH; cd05288 208964006667 NAD(P) binding site [chemical binding]; other site 208964006668 substrate binding site [chemical binding]; other site 208964006669 dimer interface [polypeptide binding]; other site 208964006670 Uncharacterized conserved protein [Function unknown]; Region: COG1359 208964006671 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 208964006672 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 208964006673 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 208964006674 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 208964006675 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 208964006676 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964006677 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 208964006678 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964006679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964006680 dimer interface [polypeptide binding]; other site 208964006681 conserved gate region; other site 208964006682 putative PBP binding loops; other site 208964006683 ABC-ATPase subunit interface; other site 208964006684 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964006685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964006686 dimer interface [polypeptide binding]; other site 208964006687 conserved gate region; other site 208964006688 putative PBP binding loops; other site 208964006689 ABC-ATPase subunit interface; other site 208964006690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964006691 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964006692 substrate binding pocket [chemical binding]; other site 208964006693 membrane-bound complex binding site; other site 208964006694 hinge residues; other site 208964006695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964006698 dimerization interface [polypeptide binding]; other site 208964006699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 208964006700 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 208964006701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 208964006702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006703 D-galactonate transporter; Region: 2A0114; TIGR00893 208964006704 putative substrate translocation pore; other site 208964006705 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 208964006706 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 208964006707 outer membrane porin, OprD family; Region: OprD; pfam03573 208964006708 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 208964006709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006710 putative substrate translocation pore; other site 208964006711 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 208964006712 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 208964006713 putative active site pocket [active] 208964006714 putative metal binding site [ion binding]; other site 208964006715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 208964006716 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 208964006717 dimer interface [polypeptide binding]; other site 208964006718 NADP binding site [chemical binding]; other site 208964006719 catalytic residues [active] 208964006720 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 208964006721 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964006722 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006724 putative substrate translocation pore; other site 208964006725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006727 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 208964006728 putative effector binding pocket; other site 208964006729 putative dimerization interface [polypeptide binding]; other site 208964006730 Helix-turn-helix domain; Region: HTH_28; pfam13518 208964006731 Winged helix-turn helix; Region: HTH_29; pfam13551 208964006732 Homeodomain-like domain; Region: HTH_32; pfam13565 208964006733 Protein of unknown function (DUF3218); Region: DUF3218; pfam11508 208964006734 Protein of unknown function (DUF3218); Region: DUF3218; pfam11508 208964006735 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964006736 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964006737 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 208964006738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 208964006739 MOSC domain; Region: MOSC; pfam03473 208964006740 3-alpha domain; Region: 3-alpha; pfam03475 208964006741 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964006742 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964006743 catalytic residue [active] 208964006744 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 208964006745 CoA-binding domain; Region: CoA_binding_3; pfam13727 208964006746 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 208964006747 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 208964006748 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 208964006749 Substrate binding site; other site 208964006750 Cupin domain; Region: Cupin_2; cl17218 208964006751 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 208964006752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 208964006753 active site 208964006754 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 208964006755 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 208964006756 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 208964006757 Predicted coiled-coil domain-containing protein; Region: KLRAQ; pfam10205 208964006758 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 208964006759 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964006760 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 208964006761 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 208964006762 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208964006763 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 208964006764 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964006765 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 208964006766 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 208964006767 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 208964006768 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 208964006769 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 208964006770 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 208964006771 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964006772 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 208964006773 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 208964006774 active site 208964006775 DNA binding site [nucleotide binding] 208964006776 Int/Topo IB signature motif; other site 208964006777 catalytic residues [active] 208964006778 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964006779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964006780 putative DNA binding site [nucleotide binding]; other site 208964006781 putative Zn2+ binding site [ion binding]; other site 208964006782 AsnC family; Region: AsnC_trans_reg; pfam01037 208964006783 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 208964006784 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 208964006785 tetramer interface [polypeptide binding]; other site 208964006786 TPP-binding site [chemical binding]; other site 208964006787 heterodimer interface [polypeptide binding]; other site 208964006788 phosphorylation loop region [posttranslational modification] 208964006789 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 208964006790 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 208964006791 alpha subunit interface [polypeptide binding]; other site 208964006792 TPP binding site [chemical binding]; other site 208964006793 heterodimer interface [polypeptide binding]; other site 208964006794 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 208964006795 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 208964006796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 208964006797 E3 interaction surface; other site 208964006798 lipoyl attachment site [posttranslational modification]; other site 208964006799 e3 binding domain; Region: E3_binding; pfam02817 208964006800 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 208964006801 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 208964006802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964006803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964006804 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 208964006805 Helix-turn-helix domain; Region: HTH_19; pfam12844 208964006806 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 208964006807 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 208964006808 active site 208964006809 homodimer interface [polypeptide binding]; other site 208964006810 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 208964006811 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 208964006812 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 208964006813 substrate binding pocket [chemical binding]; other site 208964006814 active site 208964006815 iron coordination sites [ion binding]; other site 208964006816 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 208964006817 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 208964006818 Cytochrome c553 [Energy production and conversion]; Region: COG2863 208964006819 Cytochrome c; Region: Cytochrom_C; cl11414 208964006820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006822 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964006823 putative effector binding pocket; other site 208964006824 dimerization interface [polypeptide binding]; other site 208964006825 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208964006826 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208964006827 DNA binding site [nucleotide binding] 208964006828 domain linker motif; other site 208964006829 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 208964006830 putative dimerization interface [polypeptide binding]; other site 208964006831 putative ligand binding site [chemical binding]; other site 208964006832 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 208964006833 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 208964006834 substrate binding site [chemical binding]; other site 208964006835 ATP binding site [chemical binding]; other site 208964006836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006837 D-galactonate transporter; Region: 2A0114; TIGR00893 208964006838 putative substrate translocation pore; other site 208964006839 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 208964006840 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 208964006841 dimerization interface [polypeptide binding]; other site 208964006842 ligand binding site [chemical binding]; other site 208964006843 NADP binding site [chemical binding]; other site 208964006844 catalytic site [active] 208964006845 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 208964006846 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 208964006847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964006848 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 208964006849 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964006850 Cytochrome c; Region: Cytochrom_C; pfam00034 208964006851 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964006852 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 208964006853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964006854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964006855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964006856 dimerization interface [polypeptide binding]; other site 208964006857 hypothetical protein; Validated; Region: PRK06186 208964006858 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 208964006859 active site 208964006860 putative oxyanion hole; other site 208964006861 catalytic triad [active] 208964006862 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 208964006863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964006864 putative substrate translocation pore; other site 208964006865 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964006866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964006867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964006868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 208964006869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964006870 Coenzyme A binding pocket [chemical binding]; other site 208964006871 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 208964006872 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 208964006873 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 208964006874 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 208964006875 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 208964006876 DNA binding residues [nucleotide binding] 208964006877 dimer interface [polypeptide binding]; other site 208964006878 [2Fe-2S] cluster binding site [ion binding]; other site 208964006879 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 208964006880 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 208964006881 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 208964006882 putative NAD(P) binding site [chemical binding]; other site 208964006883 putative substrate binding site [chemical binding]; other site 208964006884 catalytic Zn binding site [ion binding]; other site 208964006885 structural Zn binding site [ion binding]; other site 208964006886 dimer interface [polypeptide binding]; other site 208964006887 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 208964006888 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964006889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964006890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964006891 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964006892 dimerization interface [polypeptide binding]; other site 208964006893 putative DNA binding site [nucleotide binding]; other site 208964006894 putative Zn2+ binding site [ion binding]; other site 208964006895 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 208964006896 Citrate transporter; Region: CitMHS; pfam03600 208964006897 transmembrane helices; other site 208964006898 Low molecular weight phosphatase family; Region: LMWPc; cd00115 208964006899 active site 208964006900 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 208964006901 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964006902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964006903 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 208964006904 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 208964006905 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964006906 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964006907 N-terminal plug; other site 208964006908 ligand-binding site [chemical binding]; other site 208964006909 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 208964006910 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 208964006911 Trp docking motif [polypeptide binding]; other site 208964006912 putative active site [active] 208964006913 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 208964006914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 208964006915 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 208964006916 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 208964006917 protein binding surface [polypeptide binding]; other site 208964006918 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 208964006919 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 208964006920 Walker A/P-loop; other site 208964006921 ATP binding site [chemical binding]; other site 208964006922 Q-loop/lid; other site 208964006923 ABC transporter signature motif; other site 208964006924 Walker B; other site 208964006925 D-loop; other site 208964006926 H-loop/switch region; other site 208964006927 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964006928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964006929 dimer interface [polypeptide binding]; other site 208964006930 conserved gate region; other site 208964006931 putative PBP binding loops; other site 208964006932 ABC-ATPase subunit interface; other site 208964006933 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 208964006934 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 208964006935 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964006936 substrate binding pocket [chemical binding]; other site 208964006937 membrane-bound complex binding site; other site 208964006938 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 208964006939 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 208964006940 putative oxidoreductase; Provisional; Region: PRK08275 208964006941 L-aspartate oxidase; Provisional; Region: PRK06175 208964006942 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 208964006943 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208964006944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964006945 DNA-binding site [nucleotide binding]; DNA binding site 208964006946 UTRA domain; Region: UTRA; pfam07702 208964006947 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 208964006948 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 208964006949 putative active site [active] 208964006950 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 208964006951 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 208964006952 Interdomain contacts; other site 208964006953 Cytokine receptor motif; other site 208964006954 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 208964006955 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 208964006956 putative deacylase active site [active] 208964006957 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964006958 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 208964006959 acyl-activating enzyme (AAE) consensus motif; other site 208964006960 AMP binding site [chemical binding]; other site 208964006961 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 208964006962 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 208964006963 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964006964 Condensation domain; Region: Condensation; cl19241 208964006965 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964006966 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 208964006967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964006968 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 208964006969 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 208964006970 active site 208964006971 iron coordination sites [ion binding]; other site 208964006972 substrate binding pocket [chemical binding]; other site 208964006973 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 208964006974 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 208964006975 acyl-activating enzyme (AAE) consensus motif; other site 208964006976 AMP binding site [chemical binding]; other site 208964006977 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964006978 Condensation domain; Region: Condensation; cl19241 208964006979 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964006980 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 208964006981 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964006982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964006983 putative PBP binding loops; other site 208964006984 dimer interface [polypeptide binding]; other site 208964006985 ABC-ATPase subunit interface; other site 208964006986 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 208964006987 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 208964006988 Walker A/P-loop; other site 208964006989 ATP binding site [chemical binding]; other site 208964006990 Q-loop/lid; other site 208964006991 ABC transporter signature motif; other site 208964006992 Walker B; other site 208964006993 D-loop; other site 208964006994 H-loop/switch region; other site 208964006995 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 208964006996 NMT1-like family; Region: NMT1_2; pfam13379 208964006997 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 208964006998 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 208964006999 active site 208964007000 iron coordination sites [ion binding]; other site 208964007001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964007002 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208964007003 non-specific DNA binding site [nucleotide binding]; other site 208964007004 salt bridge; other site 208964007005 sequence-specific DNA binding site [nucleotide binding]; other site 208964007006 Cupin domain; Region: Cupin_2; pfam07883 208964007007 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964007008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964007009 putative substrate translocation pore; other site 208964007010 Beta-lactamase; Region: Beta-lactamase; pfam00144 208964007011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964007012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007013 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 208964007014 putative effector binding pocket; other site 208964007015 putative dimerization interface [polypeptide binding]; other site 208964007016 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964007017 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964007018 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 208964007019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 208964007020 Transposase; Region: DEDD_Tnp_IS110; pfam01548 208964007021 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 208964007022 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 208964007023 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208964007024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208964007025 DNA binding site [nucleotide binding] 208964007026 domain linker motif; other site 208964007027 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 208964007028 putative ligand binding site [chemical binding]; other site 208964007029 putative dimerization interface [polypeptide binding]; other site 208964007030 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 208964007031 AAA domain; Region: AAA_33; pfam13671 208964007032 ATP-binding site [chemical binding]; other site 208964007033 Gluconate-6-phosphate binding site [chemical binding]; other site 208964007034 GntP family permease; Region: GntP_permease; pfam02447 208964007035 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 208964007036 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 208964007037 tetrameric interface [polypeptide binding]; other site 208964007038 activator binding site; other site 208964007039 NADP binding site [chemical binding]; other site 208964007040 substrate binding site [chemical binding]; other site 208964007041 catalytic residues [active] 208964007042 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 208964007043 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 208964007044 Flavin binding site [chemical binding]; other site 208964007045 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 208964007046 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964007047 active site 208964007048 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 208964007049 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964007050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964007051 dimer interface [polypeptide binding]; other site 208964007052 conserved gate region; other site 208964007053 putative PBP binding loops; other site 208964007054 ABC-ATPase subunit interface; other site 208964007055 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 208964007056 NMT1-like family; Region: NMT1_2; pfam13379 208964007057 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 208964007058 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 208964007059 Walker A/P-loop; other site 208964007060 ATP binding site [chemical binding]; other site 208964007061 Q-loop/lid; other site 208964007062 ABC transporter signature motif; other site 208964007063 Walker B; other site 208964007064 D-loop; other site 208964007065 H-loop/switch region; other site 208964007066 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964007067 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964007068 active site 208964007069 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 208964007070 Uncharacterized conserved protein [Function unknown]; Region: COG2128 208964007071 Cupin; Region: Cupin_6; pfam12852 208964007072 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964007073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964007074 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 208964007075 Sulfatase; Region: Sulfatase; pfam00884 208964007076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964007077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007078 LysR substrate binding domain; Region: LysR_substrate; pfam03466 208964007079 dimerization interface [polypeptide binding]; other site 208964007080 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964007081 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 208964007082 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 208964007083 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964007084 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964007085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964007086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964007087 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 208964007088 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 208964007089 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 208964007090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964007091 dimer interface [polypeptide binding]; other site 208964007092 conserved gate region; other site 208964007093 putative PBP binding loops; other site 208964007094 ABC-ATPase subunit interface; other site 208964007095 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 208964007096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964007097 dimer interface [polypeptide binding]; other site 208964007098 conserved gate region; other site 208964007099 putative PBP binding loops; other site 208964007100 ABC-ATPase subunit interface; other site 208964007101 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 208964007102 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 208964007103 Walker A/P-loop; other site 208964007104 ATP binding site [chemical binding]; other site 208964007105 Q-loop/lid; other site 208964007106 ABC transporter signature motif; other site 208964007107 Walker B; other site 208964007108 D-loop; other site 208964007109 H-loop/switch region; other site 208964007110 TOBE domain; Region: TOBE_2; pfam08402 208964007111 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 208964007112 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 208964007113 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 208964007114 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 208964007115 N- and C-terminal domain interface [polypeptide binding]; other site 208964007116 D-xylulose kinase; Region: XylB; TIGR01312 208964007117 active site 208964007118 MgATP binding site [chemical binding]; other site 208964007119 catalytic site [active] 208964007120 metal binding site [ion binding]; metal-binding site 208964007121 xylulose binding site [chemical binding]; other site 208964007122 putative homodimer interface [polypeptide binding]; other site 208964007123 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 208964007124 putative substrate binding site [chemical binding]; other site 208964007125 putative ATP binding site [chemical binding]; other site 208964007126 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 208964007127 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 208964007128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964007129 active site 208964007130 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 208964007131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964007132 active site 208964007133 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 208964007134 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 208964007135 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 208964007136 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 208964007137 Walker A/P-loop; other site 208964007138 ATP binding site [chemical binding]; other site 208964007139 Q-loop/lid; other site 208964007140 ABC transporter signature motif; other site 208964007141 Walker B; other site 208964007142 D-loop; other site 208964007143 H-loop/switch region; other site 208964007144 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 208964007145 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 208964007146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964007147 dimer interface [polypeptide binding]; other site 208964007148 conserved gate region; other site 208964007149 putative PBP binding loops; other site 208964007150 ABC-ATPase subunit interface; other site 208964007151 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 208964007152 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 208964007153 active site 208964007154 catalytic site [active] 208964007155 metal binding site [ion binding]; metal-binding site 208964007156 Predicted ATPase [General function prediction only]; Region: COG1485 208964007157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 208964007158 Walker B; other site 208964007159 D-loop; other site 208964007160 H-loop/switch region; other site 208964007161 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 208964007162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964007163 Walker A motif; other site 208964007164 ATP binding site [chemical binding]; other site 208964007165 Walker B motif; other site 208964007166 arginine finger; other site 208964007167 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 208964007168 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 208964007169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964007170 active site 208964007171 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 208964007172 active site 208964007173 dimer interface [polypeptide binding]; other site 208964007174 non-prolyl cis peptide bond; other site 208964007175 insertion regions; other site 208964007176 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 208964007177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964007178 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 208964007179 Walker A motif; other site 208964007180 ATP binding site [chemical binding]; other site 208964007181 Walker B motif; other site 208964007182 arginine finger; other site 208964007183 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 208964007184 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 208964007185 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 208964007186 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 208964007187 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 208964007188 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 208964007189 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 208964007190 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 208964007191 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 208964007192 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 208964007193 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 208964007194 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 208964007195 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 208964007196 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 208964007197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964007198 Walker A motif; other site 208964007199 ATP binding site [chemical binding]; other site 208964007200 Walker B motif; other site 208964007201 arginine finger; other site 208964007202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964007203 Walker A motif; other site 208964007204 ATP binding site [chemical binding]; other site 208964007205 Walker B motif; other site 208964007206 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 208964007207 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964007208 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964007209 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 208964007210 MORN repeat; Region: MORN; cl14787 208964007211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 208964007212 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 208964007213 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964007214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964007215 active site 208964007216 phosphorylation site [posttranslational modification] 208964007217 intermolecular recognition site; other site 208964007218 dimerization interface [polypeptide binding]; other site 208964007219 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964007220 DNA binding residues [nucleotide binding] 208964007221 dimerization interface [polypeptide binding]; other site 208964007222 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 208964007223 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 208964007224 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964007225 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 208964007226 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964007227 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 208964007228 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964007229 catalytic loop [active] 208964007230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 208964007231 iron binding site [ion binding]; other site 208964007232 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 208964007233 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 208964007234 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 208964007235 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 208964007236 active site 208964007237 substrate binding site [chemical binding]; other site 208964007238 FMN binding site [chemical binding]; other site 208964007239 putative catalytic residues [active] 208964007240 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964007241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007242 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 208964007243 dimerization interface [polypeptide binding]; other site 208964007244 substrate binding pocket [chemical binding]; other site 208964007245 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 208964007246 Penicillin amidase; Region: Penicil_amidase; pfam01804 208964007247 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 208964007248 active site 208964007249 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 208964007250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964007251 RNA polymerase sigma factor; Reviewed; Region: PRK12527 208964007252 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964007253 DNA binding residues [nucleotide binding] 208964007254 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964007255 FecR protein; Region: FecR; pfam04773 208964007256 macrolide transporter subunit MacA; Provisional; Region: PRK11578 208964007257 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964007258 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964007259 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 208964007260 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208964007261 Walker A/P-loop; other site 208964007262 ATP binding site [chemical binding]; other site 208964007263 Q-loop/lid; other site 208964007264 ABC transporter signature motif; other site 208964007265 Walker B; other site 208964007266 D-loop; other site 208964007267 H-loop/switch region; other site 208964007268 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208964007269 FtsX-like permease family; Region: FtsX; pfam02687 208964007270 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 208964007271 Outer membrane efflux protein; Region: OEP; pfam02321 208964007272 Outer membrane efflux protein; Region: OEP; pfam02321 208964007273 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 208964007274 active site 208964007275 dimer interface [polypeptide binding]; other site 208964007276 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 208964007277 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964007278 catalytic residue [active] 208964007279 Uncharacterized conserved protein [Function unknown]; Region: COG1262 208964007280 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 208964007281 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 208964007282 active site 208964007283 cosubstrate binding site; other site 208964007284 substrate binding site [chemical binding]; other site 208964007285 catalytic site [active] 208964007286 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 208964007287 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208964007288 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 208964007289 Walker A/P-loop; other site 208964007290 ATP binding site [chemical binding]; other site 208964007291 Q-loop/lid; other site 208964007292 ABC transporter signature motif; other site 208964007293 Walker B; other site 208964007294 D-loop; other site 208964007295 H-loop/switch region; other site 208964007296 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964007297 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 208964007298 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964007299 N-terminal plug; other site 208964007300 ligand-binding site [chemical binding]; other site 208964007301 Condensation domain; Region: Condensation; pfam00668 208964007302 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 208964007303 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007304 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007305 acyl-activating enzyme (AAE) consensus motif; other site 208964007306 AMP binding site [chemical binding]; other site 208964007307 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007308 Condensation domain; Region: Condensation; pfam00668 208964007309 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 208964007310 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007311 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007312 acyl-activating enzyme (AAE) consensus motif; other site 208964007313 AMP binding site [chemical binding]; other site 208964007314 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007315 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964007316 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 208964007317 Condensation domain; Region: Condensation; pfam00668 208964007318 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 208964007319 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007320 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007321 acyl-activating enzyme (AAE) consensus motif; other site 208964007322 AMP binding site [chemical binding]; other site 208964007323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007324 Condensation domain; Region: Condensation; pfam00668 208964007325 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 208964007326 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007327 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007328 acyl-activating enzyme (AAE) consensus motif; other site 208964007329 AMP binding site [chemical binding]; other site 208964007330 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007331 peptide synthase; Provisional; Region: PRK12316 208964007332 Condensation domain; Region: Condensation; pfam00668 208964007333 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007334 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007335 acyl-activating enzyme (AAE) consensus motif; other site 208964007336 AMP binding site [chemical binding]; other site 208964007337 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007338 Condensation domain; Region: Condensation; pfam00668 208964007339 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 208964007340 Condensation domain; Region: Condensation; pfam00668 208964007341 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007342 acyl-activating enzyme (AAE) consensus motif; other site 208964007343 AMP binding site [chemical binding]; other site 208964007344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007345 Condensation domain; Region: Condensation; pfam00668 208964007346 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007347 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007348 acyl-activating enzyme (AAE) consensus motif; other site 208964007349 AMP binding site [chemical binding]; other site 208964007350 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007351 Condensation domain; Region: Condensation; pfam00668 208964007352 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 208964007353 Condensation domain; Region: Condensation; pfam00668 208964007354 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007355 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007356 acyl-activating enzyme (AAE) consensus motif; other site 208964007357 AMP binding site [chemical binding]; other site 208964007358 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007359 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 208964007360 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 208964007361 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 208964007362 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 208964007363 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 208964007364 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 208964007365 metal binding site [ion binding]; metal-binding site 208964007366 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 208964007367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964007368 Walker A/P-loop; other site 208964007369 ATP binding site [chemical binding]; other site 208964007370 Q-loop/lid; other site 208964007371 ABC transporter signature motif; other site 208964007372 Walker B; other site 208964007373 D-loop; other site 208964007374 H-loop/switch region; other site 208964007375 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 208964007376 ABC-ATPase subunit interface; other site 208964007377 dimer interface [polypeptide binding]; other site 208964007378 putative PBP binding regions; other site 208964007379 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 208964007380 Periplasmic solute binding protein family; Region: TroA; pfam01297 208964007381 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 208964007382 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964007383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 208964007384 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964007385 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964007386 inhibitor-cofactor binding pocket; inhibition site 208964007387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964007388 catalytic residue [active] 208964007389 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 208964007390 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 208964007391 Predicted membrane protein [Function unknown]; Region: COG4244 208964007392 trehalase; Provisional; Region: treA; PRK13272 208964007393 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 208964007394 LysR family transcriptional regulator; Provisional; Region: PRK14997 208964007395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007396 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 208964007397 putative effector binding pocket; other site 208964007398 putative dimerization interface [polypeptide binding]; other site 208964007399 Pirin-related protein [General function prediction only]; Region: COG1741 208964007400 Pirin; Region: Pirin; pfam02678 208964007401 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 208964007402 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 208964007403 catalytic triad [active] 208964007404 dimer interface [polypeptide binding]; other site 208964007405 conserved cis-peptide bond; other site 208964007406 outer membrane porin, OprD family; Region: OprD; pfam03573 208964007407 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 208964007408 Prophage antirepressor [Transcription]; Region: COG3617 208964007409 BRO family, N-terminal domain; Region: Bro-N; smart01040 208964007410 peptide synthase; Validated; Region: PRK05691 208964007411 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 208964007412 acyl-activating enzyme (AAE) consensus motif; other site 208964007413 active site 208964007414 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007415 Condensation domain; Region: Condensation; pfam00668 208964007416 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007417 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007418 acyl-activating enzyme (AAE) consensus motif; other site 208964007419 AMP binding site [chemical binding]; other site 208964007420 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007421 Condensation domain; Region: Condensation; pfam00668 208964007422 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007423 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007424 acyl-activating enzyme (AAE) consensus motif; other site 208964007425 AMP binding site [chemical binding]; other site 208964007426 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007427 Condensation domain; Region: Condensation; pfam00668 208964007428 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 208964007429 Condensation domain; Region: Condensation; pfam00668 208964007430 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964007431 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964007432 acyl-activating enzyme (AAE) consensus motif; other site 208964007433 AMP binding site [chemical binding]; other site 208964007434 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964007435 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 208964007436 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964007437 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 208964007438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964007439 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964007440 DNA binding residues [nucleotide binding] 208964007441 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 208964007442 multidrug resistance protein MdtN; Provisional; Region: PRK10476 208964007443 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964007444 Protein of unknown function (DUF745); Region: DUF745; pfam05335 208964007445 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964007446 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 208964007447 Fusaric acid resistance protein family; Region: FUSC; pfam04632 208964007448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964007449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007450 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964007451 putative effector binding pocket; other site 208964007452 dimerization interface [polypeptide binding]; other site 208964007453 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 208964007454 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208964007455 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208964007456 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 208964007457 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 208964007458 HflC protein; Region: hflC; TIGR01932 208964007459 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 208964007460 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 208964007461 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 208964007462 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 208964007463 putative active site [active] 208964007464 putative metal binding site [ion binding]; other site 208964007465 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 208964007466 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 208964007467 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 208964007468 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 208964007469 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 208964007470 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 208964007471 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 208964007472 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 208964007473 dimer interface [polypeptide binding]; other site 208964007474 active site 208964007475 glycine-pyridoxal phosphate binding site [chemical binding]; other site 208964007476 folate binding site [chemical binding]; other site 208964007477 glycine dehydrogenase; Provisional; Region: PRK05367 208964007478 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 208964007479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964007480 catalytic residue [active] 208964007481 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 208964007482 tetramer interface [polypeptide binding]; other site 208964007483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964007484 catalytic residue [active] 208964007485 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 208964007486 lipoyl attachment site [posttranslational modification]; other site 208964007487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964007488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007489 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964007490 putative effector binding pocket; other site 208964007491 dimerization interface [polypeptide binding]; other site 208964007492 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 208964007493 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 208964007494 active site 208964007495 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 208964007496 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 208964007497 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 208964007498 PAS domain; Region: PAS_8; pfam13188 208964007499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964007500 Walker A motif; other site 208964007501 ATP binding site [chemical binding]; other site 208964007502 Walker B motif; other site 208964007503 arginine finger; other site 208964007504 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 208964007505 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964007506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964007507 S-adenosylmethionine binding site [chemical binding]; other site 208964007508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964007509 Coenzyme A binding pocket [chemical binding]; other site 208964007510 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 208964007511 RHS Repeat; Region: RHS_repeat; pfam05593 208964007512 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 208964007513 RHS Repeat; Region: RHS_repeat; pfam05593 208964007514 RHS Repeat; Region: RHS_repeat; pfam05593 208964007515 RHS Repeat; Region: RHS_repeat; pfam05593 208964007516 RHS Repeat; Region: RHS_repeat; pfam05593 208964007517 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 208964007518 RHS Repeat; Region: RHS_repeat; pfam05593 208964007519 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 208964007520 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 208964007521 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 208964007522 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 208964007523 haemagglutination activity domain; Region: Haemagg_act; pfam05860 208964007524 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 208964007525 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 208964007526 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 208964007527 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 208964007528 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 208964007529 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 208964007530 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 208964007531 Surface antigen; Region: Bac_surface_Ag; pfam01103 208964007532 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 208964007533 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 208964007534 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 208964007535 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964007536 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 208964007537 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964007538 N-terminal plug; other site 208964007539 ligand-binding site [chemical binding]; other site 208964007540 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964007541 FecR protein; Region: FecR; pfam04773 208964007542 RNA polymerase sigma factor; Reviewed; Region: PRK12523 208964007543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964007544 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964007545 DNA binding residues [nucleotide binding] 208964007546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007547 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 208964007548 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964007549 dimerization interface [polypeptide binding]; other site 208964007550 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 208964007551 Cupin domain; Region: Cupin_2; pfam07883 208964007552 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 208964007553 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 208964007554 benzoate transport; Region: 2A0115; TIGR00895 208964007555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964007556 putative substrate translocation pore; other site 208964007557 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 208964007558 maleylacetoacetate isomerase; Region: maiA; TIGR01262 208964007559 C-terminal domain interface [polypeptide binding]; other site 208964007560 GSH binding site (G-site) [chemical binding]; other site 208964007561 putative dimer interface [polypeptide binding]; other site 208964007562 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 208964007563 dimer interface [polypeptide binding]; other site 208964007564 N-terminal domain interface [polypeptide binding]; other site 208964007565 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 208964007566 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 208964007567 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 208964007568 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 208964007569 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 208964007570 dimerization domain [polypeptide binding]; other site 208964007571 dimer interface [polypeptide binding]; other site 208964007572 catalytic residues [active] 208964007573 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 208964007574 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 208964007575 catalytic residues [active] 208964007576 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 208964007577 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 208964007578 Sulfite exporter TauE/SafE; Region: TauE; cl19196 208964007579 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 208964007580 DsbD alpha interface [polypeptide binding]; other site 208964007581 catalytic residues [active] 208964007582 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 208964007583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964007584 active site 208964007585 phosphorylation site [posttranslational modification] 208964007586 intermolecular recognition site; other site 208964007587 dimerization interface [polypeptide binding]; other site 208964007588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964007589 DNA binding site [nucleotide binding] 208964007590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964007591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964007592 dimer interface [polypeptide binding]; other site 208964007593 phosphorylation site [posttranslational modification] 208964007594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964007595 ATP binding site [chemical binding]; other site 208964007596 Mg2+ binding site [ion binding]; other site 208964007597 G-X-G motif; other site 208964007598 Cytochrome c [Energy production and conversion]; Region: COG3258 208964007599 Cytochrome c; Region: Cytochrom_C; pfam00034 208964007600 Cytochrome c553 [Energy production and conversion]; Region: COG2863 208964007601 Cytochrome c; Region: Cytochrom_C; cl11414 208964007602 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 208964007603 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 208964007604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964007605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964007606 acyl-CoA dehydrogenase; Provisional; Region: PTZ00460 208964007607 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964007608 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964007609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964007610 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964007611 Helix-turn-helix domain; Region: HTH_18; pfam12833 208964007612 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 208964007613 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 208964007614 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 208964007615 putative NAD(P) binding site [chemical binding]; other site 208964007616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964007617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007618 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 208964007619 putative substrate binding pocket [chemical binding]; other site 208964007620 putative dimerization interface [polypeptide binding]; other site 208964007621 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964007622 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964007623 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964007624 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 208964007625 MMPL family; Region: MMPL; cl14618 208964007626 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 208964007627 Outer membrane efflux protein; Region: OEP; pfam02321 208964007628 Outer membrane efflux protein; Region: OEP; pfam02321 208964007629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 208964007630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964007631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007632 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964007633 dimerization interface [polypeptide binding]; other site 208964007634 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 208964007635 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 208964007636 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 208964007637 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 208964007638 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 208964007639 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 208964007640 nucleoside/Zn binding site; other site 208964007641 dimer interface [polypeptide binding]; other site 208964007642 catalytic motif [active] 208964007643 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 208964007644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964007645 putative substrate translocation pore; other site 208964007646 Leucine rich repeat; Region: LRR_8; pfam13855 208964007647 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 208964007648 Leucine rich repeat; Region: LRR_8; pfam13855 208964007649 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 208964007650 active site 208964007651 ATP binding site [chemical binding]; other site 208964007652 substrate binding site [chemical binding]; other site 208964007653 activation loop (A-loop); other site 208964007654 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 208964007655 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 208964007656 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 208964007657 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl19625 208964007658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4859 208964007659 outer membrane porin, OprD family; Region: OprD; pfam03573 208964007660 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 208964007661 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 208964007662 active site 208964007663 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 208964007664 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 208964007665 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 208964007666 octamer interface [polypeptide binding]; other site 208964007667 active site 208964007668 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 208964007669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007670 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 208964007671 dimerizarion interface [polypeptide binding]; other site 208964007672 CrgA pocket; other site 208964007673 substrate binding pocket [chemical binding]; other site 208964007674 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 208964007675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964007676 Helix-turn-helix domain; Region: HTH_18; pfam12833 208964007677 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 208964007678 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 208964007679 [2Fe-2S] cluster binding site [ion binding]; other site 208964007680 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 208964007681 putative alpha subunit interface [polypeptide binding]; other site 208964007682 putative active site [active] 208964007683 putative substrate binding site [chemical binding]; other site 208964007684 Fe binding site [ion binding]; other site 208964007685 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 208964007686 inter-subunit interface; other site 208964007687 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 208964007688 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964007689 catalytic loop [active] 208964007690 iron binding site [ion binding]; other site 208964007691 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 208964007692 FAD binding pocket [chemical binding]; other site 208964007693 FAD binding motif [chemical binding]; other site 208964007694 phosphate binding motif [ion binding]; other site 208964007695 beta-alpha-beta structure motif; other site 208964007696 NAD binding pocket [chemical binding]; other site 208964007697 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 208964007698 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 208964007699 putative NAD(P) binding site [chemical binding]; other site 208964007700 active site 208964007701 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 208964007702 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964007703 catalytic loop [active] 208964007704 iron binding site [ion binding]; other site 208964007705 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 208964007706 FAD binding pocket [chemical binding]; other site 208964007707 FAD binding motif [chemical binding]; other site 208964007708 phosphate binding motif [ion binding]; other site 208964007709 beta-alpha-beta structure motif; other site 208964007710 NAD binding pocket [chemical binding]; other site 208964007711 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 208964007712 inter-subunit interface; other site 208964007713 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 208964007714 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 208964007715 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 208964007716 putative alpha subunit interface [polypeptide binding]; other site 208964007717 putative active site [active] 208964007718 putative substrate binding site [chemical binding]; other site 208964007719 Fe binding site [ion binding]; other site 208964007720 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 208964007721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964007722 Helix-turn-helix domain; Region: HTH_18; pfam12833 208964007723 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 208964007724 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964007725 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 208964007726 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964007727 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964007728 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 208964007729 Outer membrane efflux protein; Region: OEP; pfam02321 208964007730 Outer membrane efflux protein; Region: OEP; pfam02321 208964007731 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 208964007732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964007733 active site 208964007734 phosphorylation site [posttranslational modification] 208964007735 intermolecular recognition site; other site 208964007736 dimerization interface [polypeptide binding]; other site 208964007737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964007738 DNA binding site [nucleotide binding] 208964007739 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 208964007740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964007741 dimerization interface [polypeptide binding]; other site 208964007742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964007743 dimer interface [polypeptide binding]; other site 208964007744 phosphorylation site [posttranslational modification] 208964007745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964007746 ATP binding site [chemical binding]; other site 208964007747 Mg2+ binding site [ion binding]; other site 208964007748 G-X-G motif; other site 208964007749 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 208964007750 Outer membrane efflux protein; Region: OEP; pfam02321 208964007751 Outer membrane efflux protein; Region: OEP; pfam02321 208964007752 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 208964007753 MMPL family; Region: MMPL; cl14618 208964007754 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 208964007755 MMPL family; Region: MMPL; cl14618 208964007756 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl19910 208964007757 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 208964007758 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964007759 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964007760 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 208964007761 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 208964007762 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 208964007763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964007764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964007765 homodimer interface [polypeptide binding]; other site 208964007766 catalytic residue [active] 208964007767 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 208964007768 dimer interface [polypeptide binding]; other site 208964007769 catalytic triad [active] 208964007770 peroxidatic and resolving cysteines [active] 208964007771 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 208964007772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007773 LysR family transcriptional regulator; Provisional; Region: PRK14997 208964007774 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 208964007775 putative effector binding pocket; other site 208964007776 putative dimerization interface [polypeptide binding]; other site 208964007777 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208964007778 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 208964007779 active site 208964007780 catalytic tetrad [active] 208964007781 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 208964007782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 208964007783 putative acyl-acceptor binding pocket; other site 208964007784 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 208964007785 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 208964007786 active site 208964007787 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 208964007788 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 208964007789 active site 208964007790 catalytic residues [active] 208964007791 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 208964007792 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 208964007793 Putative methyltransferase; Region: Methyltransf_20; pfam12147 208964007794 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 208964007795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 208964007796 Family of unknown function (DUF490); Region: DUF490; pfam04357 208964007797 Family of unknown function (DUF490); Region: DUF490; pfam04357 208964007798 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 208964007799 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 208964007800 Surface antigen; Region: Bac_surface_Ag; pfam01103 208964007801 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208964007802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964007803 Coenzyme A binding pocket [chemical binding]; other site 208964007804 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 208964007805 putative catalytic site [active] 208964007806 putative phosphate binding site [ion binding]; other site 208964007807 active site 208964007808 metal binding site A [ion binding]; metal-binding site 208964007809 DNA binding site [nucleotide binding] 208964007810 putative AP binding site [nucleotide binding]; other site 208964007811 putative metal binding site B [ion binding]; other site 208964007812 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 208964007813 dimer interface [polypeptide binding]; other site 208964007814 metal binding site [ion binding]; metal-binding site 208964007815 LysR family transcriptional regulator; Provisional; Region: PRK14997 208964007816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007817 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964007818 putative effector binding pocket; other site 208964007819 dimerization interface [polypeptide binding]; other site 208964007820 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 208964007821 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964007822 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964007823 ligand binding site [chemical binding]; other site 208964007824 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 208964007825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964007826 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 208964007827 FAD binding site [chemical binding]; other site 208964007828 substrate binding site [chemical binding]; other site 208964007829 catalytic base [active] 208964007830 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 208964007831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964007832 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 208964007833 substrate binding pocket [chemical binding]; other site 208964007834 dimerization interface [polypeptide binding]; other site 208964007835 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964007836 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964007837 active site 208964007838 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 208964007839 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964007840 dimer interface [polypeptide binding]; other site 208964007841 active site 208964007842 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 208964007843 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 208964007844 NAD binding site [chemical binding]; other site 208964007845 homodimer interface [polypeptide binding]; other site 208964007846 homotetramer interface [polypeptide binding]; other site 208964007847 active site 208964007848 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 208964007849 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 208964007850 acyl-activating enzyme (AAE) consensus motif; other site 208964007851 AMP binding site [chemical binding]; other site 208964007852 active site 208964007853 CoA binding site [chemical binding]; other site 208964007854 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964007855 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964007856 SurA N-terminal domain; Region: SurA_N; pfam09312 208964007857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964007858 AMP-binding domain protein; Validated; Region: PRK08315 208964007859 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 208964007860 acyl-activating enzyme (AAE) consensus motif; other site 208964007861 putative AMP binding site [chemical binding]; other site 208964007862 putative active site [active] 208964007863 putative CoA binding site [chemical binding]; other site 208964007864 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 208964007865 MgtC family; Region: MgtC; pfam02308 208964007866 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 208964007867 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964007868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964007869 dimerization interface [polypeptide binding]; other site 208964007870 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964007871 dimer interface [polypeptide binding]; other site 208964007872 putative CheW interface [polypeptide binding]; other site 208964007873 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 208964007874 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 208964007875 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 208964007876 Sulfate transporter family; Region: Sulfate_transp; pfam00916 208964007877 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 208964007878 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 208964007879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964007880 S-adenosylmethionine binding site [chemical binding]; other site 208964007881 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 208964007882 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 208964007883 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 208964007884 metal binding site [ion binding]; metal-binding site 208964007885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964007886 PA-IL-like protein; Region: PA-IL; pfam07828 208964007887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964007888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964007889 dimer interface [polypeptide binding]; other site 208964007890 phosphorylation site [posttranslational modification] 208964007891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964007892 ATP binding site [chemical binding]; other site 208964007893 Mg2+ binding site [ion binding]; other site 208964007894 G-X-G motif; other site 208964007895 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 208964007896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964007897 active site 208964007898 phosphorylation site [posttranslational modification] 208964007899 intermolecular recognition site; other site 208964007900 dimerization interface [polypeptide binding]; other site 208964007901 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964007902 Zn2+ binding site [ion binding]; other site 208964007903 Mg2+ binding site [ion binding]; other site 208964007904 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964007905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964007906 dimerization interface [polypeptide binding]; other site 208964007907 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964007908 dimer interface [polypeptide binding]; other site 208964007909 putative CheW interface [polypeptide binding]; other site 208964007910 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 208964007911 Di-iron ligands [ion binding]; other site 208964007912 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 208964007913 dimer interface [polypeptide binding]; other site 208964007914 FMN binding site [chemical binding]; other site 208964007915 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964007916 EamA-like transporter family; Region: EamA; pfam00892 208964007917 EamA-like transporter family; Region: EamA; pfam00892 208964007918 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964007919 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 208964007920 putative DNA binding site [nucleotide binding]; other site 208964007921 putative Zn2+ binding site [ion binding]; other site 208964007922 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 208964007923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964007924 Coenzyme A binding pocket [chemical binding]; other site 208964007925 Tryptophan 2,3-dioxygenase (vermilion) [Amino acid transport and metabolism]; Region: TDO2; COG3483 208964007926 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 208964007927 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 208964007928 putative kissing complex interaction region; other site 208964007929 putative RNA binding sites [nucleotide binding]; other site 208964007930 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 208964007931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964007932 substrate binding pocket [chemical binding]; other site 208964007933 membrane-bound complex binding site; other site 208964007934 hinge residues; other site 208964007935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964007936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964007937 substrate binding pocket [chemical binding]; other site 208964007938 membrane-bound complex binding site; other site 208964007939 hinge residues; other site 208964007940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964007941 dimer interface [polypeptide binding]; other site 208964007942 phosphorylation site [posttranslational modification] 208964007943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964007944 ATP binding site [chemical binding]; other site 208964007945 Mg2+ binding site [ion binding]; other site 208964007946 G-X-G motif; other site 208964007947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964007948 active site 208964007949 phosphorylation site [posttranslational modification] 208964007950 intermolecular recognition site; other site 208964007951 dimerization interface [polypeptide binding]; other site 208964007952 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 208964007953 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 208964007954 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 208964007955 GIY-YIG motif/motif A; other site 208964007956 active site 208964007957 catalytic site [active] 208964007958 putative DNA binding site [nucleotide binding]; other site 208964007959 metal binding site [ion binding]; metal-binding site 208964007960 UvrB/uvrC motif; Region: UVR; pfam02151 208964007961 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 208964007962 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 208964007963 DNA binding site [nucleotide binding] 208964007964 response regulator; Provisional; Region: PRK09483 208964007965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964007966 active site 208964007967 phosphorylation site [posttranslational modification] 208964007968 intermolecular recognition site; other site 208964007969 dimerization interface [polypeptide binding]; other site 208964007970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964007971 DNA binding residues [nucleotide binding] 208964007972 dimerization interface [polypeptide binding]; other site 208964007973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964007974 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 208964007975 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964007976 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964007977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964007978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964007979 putative substrate translocation pore; other site 208964007980 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964007981 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964007982 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964007983 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964007984 N-terminal plug; other site 208964007985 ligand-binding site [chemical binding]; other site 208964007986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964007987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964007988 DNA binding residues [nucleotide binding] 208964007989 dimerization interface [polypeptide binding]; other site 208964007990 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 208964007991 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 208964007992 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964007993 substrate binding pocket [chemical binding]; other site 208964007994 membrane-bound complex binding site; other site 208964007995 hinge residues; other site 208964007996 NMT1-like family; Region: NMT1_2; cl17432 208964007997 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 208964007998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964007999 membrane-bound complex binding site; other site 208964008000 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 208964008001 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964008002 substrate binding pocket [chemical binding]; other site 208964008003 membrane-bound complex binding site; other site 208964008004 hinge residues; other site 208964008005 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964008006 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 208964008007 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 208964008008 dimer interface [polypeptide binding]; other site 208964008009 active site 208964008010 non-prolyl cis peptide bond; other site 208964008011 insertion regions; other site 208964008012 NMT1-like family; Region: NMT1_2; cl17432 208964008013 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 208964008014 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964008015 substrate binding pocket [chemical binding]; other site 208964008016 membrane-bound complex binding site; other site 208964008017 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 208964008018 dimer interface [polypeptide binding]; other site 208964008019 active site 208964008020 non-prolyl cis peptide bond; other site 208964008021 insertion regions; other site 208964008022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008024 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964008025 dimerization interface [polypeptide binding]; other site 208964008026 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 208964008027 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 208964008028 active site residue [active] 208964008029 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 208964008030 active site residue [active] 208964008031 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 208964008032 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 208964008033 active site residue [active] 208964008034 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 208964008035 active site residue [active] 208964008036 YccA-like proteins; Region: YccA_like; cd10433 208964008037 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 208964008038 sulfur relay protein TusC; Validated; Region: PRK00211 208964008039 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 208964008040 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 208964008041 hypothetical protein; Validated; Region: PRK09071 208964008042 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 208964008043 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 208964008044 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 208964008045 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 208964008046 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 208964008047 putative dimer interface [polypeptide binding]; other site 208964008048 N-terminal domain interface [polypeptide binding]; other site 208964008049 putative substrate binding pocket (H-site) [chemical binding]; other site 208964008050 siroheme synthase; Provisional; Region: cysG; PRK10637 208964008051 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 208964008052 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 208964008053 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 208964008054 active site 208964008055 SAM binding site [chemical binding]; other site 208964008056 homodimer interface [polypeptide binding]; other site 208964008057 seryl-tRNA synthetase; Provisional; Region: PRK05431 208964008058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 208964008059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 208964008060 dimer interface [polypeptide binding]; other site 208964008061 active site 208964008062 motif 1; other site 208964008063 motif 2; other site 208964008064 motif 3; other site 208964008065 recombination factor protein RarA; Reviewed; Region: PRK13342 208964008066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964008067 Walker A motif; other site 208964008068 ATP binding site [chemical binding]; other site 208964008069 Walker B motif; other site 208964008070 arginine finger; other site 208964008071 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 208964008072 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 208964008073 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 208964008074 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 208964008075 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 208964008076 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 208964008077 thioredoxin reductase; Provisional; Region: PRK10262 208964008078 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964008079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964008080 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 208964008081 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 208964008082 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 208964008083 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 208964008084 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 208964008085 rRNA binding site [nucleotide binding]; other site 208964008086 predicted 30S ribosome binding site; other site 208964008087 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 208964008088 Clp amino terminal domain; Region: Clp_N; pfam02861 208964008089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964008090 Walker A motif; other site 208964008091 ATP binding site [chemical binding]; other site 208964008092 Walker B motif; other site 208964008093 arginine finger; other site 208964008094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964008095 Walker A motif; other site 208964008096 ATP binding site [chemical binding]; other site 208964008097 Walker B motif; other site 208964008098 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 208964008099 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 208964008100 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208964008101 DNA-binding site [nucleotide binding]; DNA binding site 208964008102 RNA-binding motif; other site 208964008103 isocitrate dehydrogenase; Reviewed; Region: PRK07006 208964008104 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 208964008105 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 208964008106 nudix motif; other site 208964008107 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 208964008108 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 208964008109 Ligand Binding Site [chemical binding]; other site 208964008110 putative lysogenization regulator; Reviewed; Region: PRK00218 208964008111 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964008112 EamA-like transporter family; Region: EamA; pfam00892 208964008113 adenylosuccinate lyase; Provisional; Region: PRK09285 208964008114 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 208964008115 tetramer interface [polypeptide binding]; other site 208964008116 active site 208964008117 Uncharacterized conserved protein [Function unknown]; Region: COG2850 208964008118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 208964008119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964008120 Coenzyme A binding pocket [chemical binding]; other site 208964008121 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964008122 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 208964008123 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 208964008124 tetramer interface [polypeptide binding]; other site 208964008125 active site 208964008126 Mg2+/Mn2+ binding site [ion binding]; other site 208964008127 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 208964008128 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 208964008129 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964008130 CoenzymeA binding site [chemical binding]; other site 208964008131 subunit interaction site [polypeptide binding]; other site 208964008132 PHB binding site; other site 208964008133 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 208964008134 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 208964008135 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 208964008136 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 208964008137 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 208964008138 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 208964008139 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 208964008140 putative dimer interface [polypeptide binding]; other site 208964008141 [2Fe-2S] cluster binding site [ion binding]; other site 208964008142 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 208964008143 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 208964008144 SLBB domain; Region: SLBB; pfam10531 208964008145 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 208964008146 NADH dehydrogenase subunit G; Validated; Region: PRK08166 208964008147 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964008148 catalytic loop [active] 208964008149 iron binding site [ion binding]; other site 208964008150 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 208964008151 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 208964008152 [4Fe-4S] binding site [ion binding]; other site 208964008153 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 208964008154 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 208964008155 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 208964008156 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 208964008157 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 208964008158 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 208964008159 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 208964008160 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 208964008161 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 208964008162 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 208964008163 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 208964008164 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 208964008165 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 208964008166 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 208964008167 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 208964008168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964008169 S-adenosylmethionine binding site [chemical binding]; other site 208964008170 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 208964008171 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 208964008172 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964008173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964008174 dimerization interface [polypeptide binding]; other site 208964008175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964008176 dimer interface [polypeptide binding]; other site 208964008177 putative CheW interface [polypeptide binding]; other site 208964008178 Predicted permease [General function prediction only]; Region: COG2056 208964008179 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 208964008180 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 208964008181 Cache domain; Region: Cache_1; pfam02743 208964008182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964008183 dimerization interface [polypeptide binding]; other site 208964008184 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964008185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964008186 dimer interface [polypeptide binding]; other site 208964008187 putative CheW interface [polypeptide binding]; other site 208964008188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964008189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964008190 ATP binding site [chemical binding]; other site 208964008191 Mg2+ binding site [ion binding]; other site 208964008192 G-X-G motif; other site 208964008193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964008194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964008195 active site 208964008196 phosphorylation site [posttranslational modification] 208964008197 intermolecular recognition site; other site 208964008198 dimerization interface [polypeptide binding]; other site 208964008199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964008200 DNA binding site [nucleotide binding] 208964008201 Predicted membrane protein [Function unknown]; Region: COG3212 208964008202 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 208964008203 Predicted membrane protein [Function unknown]; Region: COG3212 208964008204 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 208964008205 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 208964008206 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 208964008207 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 208964008208 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 208964008209 heme-binding site [chemical binding]; other site 208964008210 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 208964008211 FAD binding pocket [chemical binding]; other site 208964008212 FAD binding motif [chemical binding]; other site 208964008213 phosphate binding motif [ion binding]; other site 208964008214 beta-alpha-beta structure motif; other site 208964008215 NAD binding pocket [chemical binding]; other site 208964008216 Heme binding pocket [chemical binding]; other site 208964008217 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 208964008218 GAF domain; Region: GAF; pfam01590 208964008219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964008220 Walker A motif; other site 208964008221 ATP binding site [chemical binding]; other site 208964008222 Walker B motif; other site 208964008223 arginine finger; other site 208964008224 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 208964008225 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 208964008226 active site 208964008227 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 208964008228 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 208964008229 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 208964008230 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 208964008231 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 208964008232 Type II secretion system (T2SS), protein J; Region: T2SJ; cl19722 208964008233 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 208964008234 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 208964008235 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 208964008236 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 208964008237 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 208964008238 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 208964008239 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 208964008240 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 208964008241 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 208964008242 Walker A motif; other site 208964008243 ATP binding site [chemical binding]; other site 208964008244 Walker B motif; other site 208964008245 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 208964008246 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 208964008247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964008248 S-adenosylmethionine binding site [chemical binding]; other site 208964008249 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 208964008250 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 208964008251 NADP binding site [chemical binding]; other site 208964008252 dimer interface [polypeptide binding]; other site 208964008253 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008255 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964008256 putative effector binding pocket; other site 208964008257 dimerization interface [polypeptide binding]; other site 208964008258 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 208964008259 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 208964008260 SnoaL-like domain; Region: SnoaL_2; pfam12680 208964008261 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 208964008262 tetramer interface [polypeptide binding]; other site 208964008263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964008264 catalytic residue [active] 208964008265 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 208964008266 RHS Repeat; Region: RHS_repeat; pfam05593 208964008267 RHS Repeat; Region: RHS_repeat; pfam05593 208964008268 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 208964008269 RHS Repeat; Region: RHS_repeat; pfam05593 208964008270 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 208964008271 RHS Repeat; Region: RHS_repeat; pfam05593 208964008272 RHS Repeat; Region: RHS_repeat; pfam05593 208964008273 RHS protein; Region: RHS; pfam03527 208964008274 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 208964008275 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 208964008276 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964008277 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964008278 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 208964008279 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 208964008280 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964008281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964008282 active site 208964008283 phosphorylation site [posttranslational modification] 208964008284 intermolecular recognition site; other site 208964008285 dimerization interface [polypeptide binding]; other site 208964008286 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964008287 DNA binding site [nucleotide binding] 208964008288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964008289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964008290 dimerization interface [polypeptide binding]; other site 208964008291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964008292 dimer interface [polypeptide binding]; other site 208964008293 phosphorylation site [posttranslational modification] 208964008294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964008295 ATP binding site [chemical binding]; other site 208964008296 Mg2+ binding site [ion binding]; other site 208964008297 G-X-G motif; other site 208964008298 outer membrane receptor FepA; Provisional; Region: PRK13524 208964008299 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964008300 N-terminal plug; other site 208964008301 ligand-binding site [chemical binding]; other site 208964008302 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 208964008303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 208964008304 Transposase; Region: DEDD_Tnp_IS110; pfam01548 208964008305 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 208964008306 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 208964008307 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 208964008308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964008309 Predicted transcriptional regulator [Transcription]; Region: COG1959 208964008310 Rrf2 family protein; Region: rrf2_super; TIGR00738 208964008311 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 208964008312 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 208964008313 catalytic residues [active] 208964008314 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 208964008315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964008316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964008317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317 208964008318 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 208964008319 catalytic triad [active] 208964008320 dimer interface [polypeptide binding]; other site 208964008321 conserved cis-peptide bond; other site 208964008322 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 208964008323 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 208964008324 active site 208964008325 outer membrane porin, OprD family; Region: OprD; pfam03573 208964008326 Transmembrane secretion effector; Region: MFS_3; pfam05977 208964008327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964008328 putative substrate translocation pore; other site 208964008329 Tse2 immunity protein Tsi2 and similar proteins; Region: Tsi2_like; cd11690 208964008330 dimer interface [polypeptide binding]; other site 208964008331 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964008332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964008333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 208964008334 Uncharacterized conserved protein [Function unknown]; Region: COG3791 208964008335 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 208964008336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964008337 Walker A motif; other site 208964008338 ATP binding site [chemical binding]; other site 208964008339 Walker B motif; other site 208964008340 arginine finger; other site 208964008341 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 208964008342 cysteine synthase; Region: PLN02565 208964008343 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 208964008344 dimer interface [polypeptide binding]; other site 208964008345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964008346 catalytic residue [active] 208964008347 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 208964008348 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 208964008349 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964008350 EamA-like transporter family; Region: EamA; pfam00892 208964008351 Predicted transcriptional regulators [Transcription]; Region: COG1733 208964008352 dimerization interface [polypeptide binding]; other site 208964008353 putative DNA binding site [nucleotide binding]; other site 208964008354 putative Zn2+ binding site [ion binding]; other site 208964008355 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 208964008356 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 208964008357 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 208964008358 putative [Fe4-S4] binding site [ion binding]; other site 208964008359 putative molybdopterin cofactor binding site [chemical binding]; other site 208964008360 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 208964008361 putative molybdopterin cofactor binding site; other site 208964008362 Ferredoxin [Energy production and conversion]; Region: COG1146 208964008363 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 208964008364 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 208964008365 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 208964008366 putative active site [active] 208964008367 putative FMN binding site [chemical binding]; other site 208964008368 putative substrate binding site [chemical binding]; other site 208964008369 putative catalytic residue [active] 208964008370 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964008371 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964008372 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964008373 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 208964008374 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 208964008375 DNA binding residues [nucleotide binding] 208964008376 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 208964008377 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 208964008378 potential catalytic triad [active] 208964008379 conserved cys residue [active] 208964008380 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 208964008381 dimer interface [polypeptide binding]; other site 208964008382 Uncharacterized conserved protein [Function unknown]; Region: COG3791 208964008383 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 208964008384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964008385 Zeta toxin; Region: Zeta_toxin; pfam06414 208964008386 Walker A motif; other site 208964008387 ATP binding site [chemical binding]; other site 208964008388 Walker B motif; other site 208964008389 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 208964008390 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 208964008391 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 208964008392 ribonuclease Y; Region: RNase_Y; TIGR03319 208964008393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958 208964008394 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 208964008395 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 208964008396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964008397 ATP binding site [chemical binding]; other site 208964008398 putative Mg++ binding site [ion binding]; other site 208964008399 Virulence protein [General function prediction only]; Region: COG3943 208964008400 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 208964008401 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 208964008402 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 208964008403 HsdM N-terminal domain; Region: HsdM_N; pfam12161 208964008404 Methyltransferase domain; Region: Methyltransf_26; pfam13659 208964008405 Predicted transcriptional regulator [Transcription]; Region: COG4190 208964008406 Helix-turn-helix domain; Region: HTH_20; pfam12840 208964008407 dimerization interface [polypeptide binding]; other site 208964008408 putative DNA binding site [nucleotide binding]; other site 208964008409 putative Zn2+ binding site [ion binding]; other site 208964008410 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 208964008411 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 208964008412 DNA binding residues [nucleotide binding] 208964008413 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 208964008414 DNA binding site [nucleotide binding] 208964008415 dimer interface [polypeptide binding]; other site 208964008416 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 208964008417 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 208964008418 putative tRNA-binding site [nucleotide binding]; other site 208964008419 B3/4 domain; Region: B3_4; pfam03483 208964008420 tRNA synthetase B5 domain; Region: B5; smart00874 208964008421 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 208964008422 dimer interface [polypeptide binding]; other site 208964008423 motif 1; other site 208964008424 motif 3; other site 208964008425 motif 2; other site 208964008426 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 208964008427 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 208964008428 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 208964008429 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 208964008430 dimer interface [polypeptide binding]; other site 208964008431 motif 1; other site 208964008432 active site 208964008433 motif 2; other site 208964008434 motif 3; other site 208964008435 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 208964008436 23S rRNA binding site [nucleotide binding]; other site 208964008437 L21 binding site [polypeptide binding]; other site 208964008438 L13 binding site [polypeptide binding]; other site 208964008439 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 208964008440 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 208964008441 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 208964008442 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 208964008443 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 208964008444 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 208964008445 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 208964008446 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 208964008447 active site 208964008448 dimer interface [polypeptide binding]; other site 208964008449 motif 1; other site 208964008450 motif 2; other site 208964008451 motif 3; other site 208964008452 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 208964008453 anticodon binding site; other site 208964008454 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964008455 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964008456 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 208964008457 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 208964008458 active site 208964008459 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 208964008460 Staphylococcal nuclease homologues; Region: SNc; smart00318 208964008461 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 208964008462 Catalytic site; other site 208964008463 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 208964008464 Predicted membrane protein [Function unknown]; Region: COG1238 208964008465 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 208964008466 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 208964008467 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 208964008468 secondary substrate binding site; other site 208964008469 primary substrate binding site; other site 208964008470 inhibition loop; other site 208964008471 dimerization interface [polypeptide binding]; other site 208964008472 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 208964008473 Predicted membrane protein [Function unknown]; Region: COG4125 208964008474 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 208964008475 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 208964008476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964008479 dimerization interface [polypeptide binding]; other site 208964008480 outer membrane porin, OprD family; Region: OprD; pfam03573 208964008481 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 208964008482 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 208964008483 Serine hydrolase; Region: Ser_hydrolase; cl17834 208964008484 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964008485 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 208964008486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964008487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964008488 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 208964008489 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964008490 substrate binding site [chemical binding]; other site 208964008491 oxyanion hole (OAH) forming residues; other site 208964008492 trimer interface [polypeptide binding]; other site 208964008493 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 208964008494 nudix motif; other site 208964008495 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 208964008496 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 208964008497 GAF domain; Region: GAF; pfam01590 208964008498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964008499 metal binding site [ion binding]; metal-binding site 208964008500 active site 208964008501 I-site; other site 208964008502 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 208964008503 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964008504 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964008505 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 208964008506 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 208964008507 putative active site [active] 208964008508 Tetratricopeptide repeat; Region: TPR_16; pfam13432 208964008509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964008510 TPR motif; other site 208964008511 binding surface 208964008512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208964008513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964008514 non-specific DNA binding site [nucleotide binding]; other site 208964008515 salt bridge; other site 208964008516 sequence-specific DNA binding site [nucleotide binding]; other site 208964008517 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582 208964008518 active site 208964008519 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 208964008520 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 208964008521 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 208964008522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964008523 salt bridge; other site 208964008524 non-specific DNA binding site [nucleotide binding]; other site 208964008525 sequence-specific DNA binding site [nucleotide binding]; other site 208964008526 GAF domain; Region: GAF; pfam01590 208964008527 glutamate carboxypeptidase; Reviewed; Region: PRK06133 208964008528 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 208964008529 metal binding site [ion binding]; metal-binding site 208964008530 dimer interface [polypeptide binding]; other site 208964008531 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 208964008532 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964008533 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964008534 dimer interface [polypeptide binding]; other site 208964008535 putative CheW interface [polypeptide binding]; other site 208964008536 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 208964008537 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 208964008538 FMN binding site [chemical binding]; other site 208964008539 active site 208964008540 catalytic residues [active] 208964008541 substrate binding site [chemical binding]; other site 208964008542 transaldolase-like protein; Provisional; Region: PTZ00411 208964008543 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 208964008544 active site 208964008545 dimer interface [polypeptide binding]; other site 208964008546 catalytic residue [active] 208964008547 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 208964008548 anti sigma factor interaction site; other site 208964008549 regulatory phosphorylation site [posttranslational modification]; other site 208964008550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964008551 active site 208964008552 phosphorylation site [posttranslational modification] 208964008553 intermolecular recognition site; other site 208964008554 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 208964008555 dimerization interface [polypeptide binding]; other site 208964008556 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 208964008557 PilZ domain; Region: PilZ; pfam07238 208964008558 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 208964008559 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208964008560 active site 208964008561 transcriptional regulator protein; Region: phnR; TIGR03337 208964008562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964008563 DNA-binding site [nucleotide binding]; DNA binding site 208964008564 UTRA domain; Region: UTRA; pfam07702 208964008565 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 208964008566 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 208964008567 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 208964008568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964008569 Zn2+ binding site [ion binding]; other site 208964008570 Mg2+ binding site [ion binding]; other site 208964008571 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 208964008572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 208964008573 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 208964008574 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 208964008575 Uncharacterized Cupredoxin-like subfamily; Region: Cupredoxin_like_2; cd04211 208964008576 putative Type 1 (T1) Cu binding site [ion binding]; other site 208964008577 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 208964008578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964008579 active site 208964008580 phosphorylation site [posttranslational modification] 208964008581 intermolecular recognition site; other site 208964008582 dimerization interface [polypeptide binding]; other site 208964008583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964008584 DNA binding site [nucleotide binding] 208964008585 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 208964008586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964008587 dimerization interface [polypeptide binding]; other site 208964008588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964008589 dimer interface [polypeptide binding]; other site 208964008590 phosphorylation site [posttranslational modification] 208964008591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964008592 ATP binding site [chemical binding]; other site 208964008593 Mg2+ binding site [ion binding]; other site 208964008594 G-X-G motif; other site 208964008595 inner membrane transport permease; Provisional; Region: PRK15066 208964008596 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 208964008597 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 208964008598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964008599 Walker A/P-loop; other site 208964008600 ATP binding site [chemical binding]; other site 208964008601 Q-loop/lid; other site 208964008602 ABC transporter signature motif; other site 208964008603 Walker B; other site 208964008604 D-loop; other site 208964008605 H-loop/switch region; other site 208964008606 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964008607 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 208964008608 putative C-terminal domain interface [polypeptide binding]; other site 208964008609 putative GSH binding site (G-site) [chemical binding]; other site 208964008610 putative dimer interface [polypeptide binding]; other site 208964008611 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 208964008612 putative N-terminal domain interface [polypeptide binding]; other site 208964008613 putative dimer interface [polypeptide binding]; other site 208964008614 putative substrate binding pocket (H-site) [chemical binding]; other site 208964008615 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 208964008616 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 208964008617 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 208964008618 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 208964008619 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 208964008620 active site 208964008621 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 208964008622 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 208964008623 phage resistance protein; Provisional; Region: PRK10551 208964008624 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964008625 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964008626 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 208964008627 C-terminal domain interface [polypeptide binding]; other site 208964008628 GSH binding site (G-site) [chemical binding]; other site 208964008629 dimer interface [polypeptide binding]; other site 208964008630 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 208964008631 N-terminal domain interface [polypeptide binding]; other site 208964008632 dimer interface [polypeptide binding]; other site 208964008633 substrate binding pocket (H-site) [chemical binding]; other site 208964008634 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 208964008635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964008636 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 208964008637 Walker A motif; other site 208964008638 ATP binding site [chemical binding]; other site 208964008639 Walker B motif; other site 208964008640 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 208964008641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964008642 dimer interface [polypeptide binding]; other site 208964008643 phosphorylation site [posttranslational modification] 208964008644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964008645 ATP binding site [chemical binding]; other site 208964008646 Mg2+ binding site [ion binding]; other site 208964008647 G-X-G motif; other site 208964008648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964008649 active site 208964008650 phosphorylation site [posttranslational modification] 208964008651 intermolecular recognition site; other site 208964008652 dimerization interface [polypeptide binding]; other site 208964008653 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964008654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964008655 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 208964008656 catalytic residues [active] 208964008657 dimer interface [polypeptide binding]; other site 208964008658 methionine sulfoxide reductase B; Provisional; Region: PRK00222 208964008659 aminotransferase AlaT; Validated; Region: PRK09265 208964008660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964008661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964008662 homodimer interface [polypeptide binding]; other site 208964008663 catalytic residue [active] 208964008664 heat shock protein HtpX; Provisional; Region: PRK05457 208964008665 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 208964008666 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 208964008667 putative active site [active] 208964008668 Zn binding site [ion binding]; other site 208964008669 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 208964008670 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964008671 Ligand Binding Site [chemical binding]; other site 208964008672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008674 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 208964008675 putative substrate binding pocket [chemical binding]; other site 208964008676 putative dimerization interface [polypeptide binding]; other site 208964008677 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 208964008678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964008679 putative substrate translocation pore; other site 208964008680 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 208964008681 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964008682 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964008683 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 208964008684 Outer membrane efflux protein; Region: OEP; pfam02321 208964008685 Outer membrane efflux protein; Region: OEP; pfam02321 208964008686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008688 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964008689 putative effector binding pocket; other site 208964008690 dimerization interface [polypeptide binding]; other site 208964008691 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 208964008692 putative active site [active] 208964008693 metal binding site [ion binding]; metal-binding site 208964008694 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 208964008695 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208964008696 ATP binding site [chemical binding]; other site 208964008697 Mg++ binding site [ion binding]; other site 208964008698 motif III; other site 208964008699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964008700 nucleotide binding region [chemical binding]; other site 208964008701 ATP-binding site [chemical binding]; other site 208964008702 DbpA RNA binding domain; Region: DbpA; pfam03880 208964008703 enoyl-CoA hydratase; Provisional; Region: PRK06563 208964008704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964008705 substrate binding site [chemical binding]; other site 208964008706 oxyanion hole (OAH) forming residues; other site 208964008707 trimer interface [polypeptide binding]; other site 208964008708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964008709 S-adenosylmethionine binding site [chemical binding]; other site 208964008710 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 208964008711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 208964008712 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 208964008713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964008716 dimerization interface [polypeptide binding]; other site 208964008717 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 208964008718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008720 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964008721 putative effector binding pocket; other site 208964008722 dimerization interface [polypeptide binding]; other site 208964008723 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964008724 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208964008725 dimerization interface [polypeptide binding]; other site 208964008726 putative Zn2+ binding site [ion binding]; other site 208964008727 putative DNA binding site [nucleotide binding]; other site 208964008728 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 208964008729 elongation factor P; Validated; Region: PRK00529 208964008730 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 208964008731 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 208964008732 RNA binding site [nucleotide binding]; other site 208964008733 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 208964008734 RNA binding site [nucleotide binding]; other site 208964008735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 208964008736 Protein of unknown function (DUF3359); Region: DUF3359; pfam11839 208964008737 L,D-transpeptidase; Provisional; Region: PRK10260 208964008738 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964008739 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 208964008740 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 208964008741 active site 208964008742 catalytic triad [active] 208964008743 oxyanion hole [active] 208964008744 switch loop; other site 208964008745 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 208964008746 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208964008747 Walker A/P-loop; other site 208964008748 ATP binding site [chemical binding]; other site 208964008749 Q-loop/lid; other site 208964008750 ABC transporter signature motif; other site 208964008751 Walker B; other site 208964008752 D-loop; other site 208964008753 H-loop/switch region; other site 208964008754 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 208964008755 FtsX-like permease family; Region: FtsX; pfam02687 208964008756 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 208964008757 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 208964008758 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 208964008759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 208964008760 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 208964008761 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 208964008762 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 208964008763 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 208964008764 Lipase chaperone [Posttranslational modification, protein turnover, chaperones]; Region: LimK; COG5380 208964008765 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 208964008766 Predicted membrane protein [Function unknown]; Region: COG2259 208964008767 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 208964008768 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964008769 substrate binding pocket [chemical binding]; other site 208964008770 membrane-bound complex binding site; other site 208964008771 hinge residues; other site 208964008772 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964008773 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964008774 catalytic residue [active] 208964008775 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 208964008776 active site 208964008777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964008778 dimerization interface [polypeptide binding]; other site 208964008779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964008780 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964008781 dimer interface [polypeptide binding]; other site 208964008782 putative CheW interface [polypeptide binding]; other site 208964008783 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 208964008784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3915 208964008785 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964008786 metal binding site [ion binding]; metal-binding site 208964008787 active site 208964008788 I-site; other site 208964008789 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 208964008790 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 208964008791 active site 208964008792 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 208964008793 active site 2 [active] 208964008794 active site 1 [active] 208964008795 Uncharacterized conserved protein [Function unknown]; Region: COG5607 208964008796 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 208964008797 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 208964008798 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 208964008799 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 208964008800 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 208964008801 Protein of unknown function DUF58; Region: DUF58; pfam01882 208964008802 MoxR-like ATPases [General function prediction only]; Region: COG0714 208964008803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964008804 Walker A motif; other site 208964008805 ATP binding site [chemical binding]; other site 208964008806 Walker B motif; other site 208964008807 arginine finger; other site 208964008808 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 208964008809 active site 208964008810 dimer interface [polypeptide binding]; other site 208964008811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008813 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 208964008814 putative effector binding pocket; other site 208964008815 putative dimerization interface [polypeptide binding]; other site 208964008816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 208964008817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964008818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964008820 dimerization interface [polypeptide binding]; other site 208964008821 Predicted membrane protein [Function unknown]; Region: COG4125 208964008822 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 208964008823 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 208964008824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964008825 active site 208964008826 phosphorylation site [posttranslational modification] 208964008827 intermolecular recognition site; other site 208964008828 dimerization interface [polypeptide binding]; other site 208964008829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964008830 active site 208964008831 phosphorylation site [posttranslational modification] 208964008832 intermolecular recognition site; other site 208964008833 dimerization interface [polypeptide binding]; other site 208964008834 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 208964008835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964008836 dimer interface [polypeptide binding]; other site 208964008837 phosphorylation site [posttranslational modification] 208964008838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964008839 ATP binding site [chemical binding]; other site 208964008840 Mg2+ binding site [ion binding]; other site 208964008841 G-X-G motif; other site 208964008842 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 208964008843 CAAX protease self-immunity; Region: Abi; pfam02517 208964008844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964008845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964008846 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 208964008847 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208964008848 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 208964008849 NAD(P) binding site [chemical binding]; other site 208964008850 substrate binding site [chemical binding]; other site 208964008851 homotetramer interface [polypeptide binding]; other site 208964008852 active site 208964008853 homodimer interface [polypeptide binding]; other site 208964008854 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 208964008855 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 208964008856 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 208964008857 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964008858 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964008859 active site 208964008860 enoyl-CoA hydratase; Provisional; Region: PRK05995 208964008861 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964008862 substrate binding site [chemical binding]; other site 208964008863 oxyanion hole (OAH) forming residues; other site 208964008864 trimer interface [polypeptide binding]; other site 208964008865 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 208964008866 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208964008867 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964008868 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 208964008869 Sm and related proteins; Region: Sm_like; cl00259 208964008870 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208964008871 carboxyltransferase (CT) interaction site; other site 208964008872 biotinylation site [posttranslational modification]; other site 208964008873 short chain dehydrogenase; Provisional; Region: PRK08278 208964008874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964008875 NAD(P) binding site [chemical binding]; other site 208964008876 active site 208964008877 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 208964008878 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 208964008879 acyl-activating enzyme (AAE) consensus motif; other site 208964008880 putative AMP binding site [chemical binding]; other site 208964008881 putative active site [active] 208964008882 putative CoA binding site [chemical binding]; other site 208964008883 RNA polymerase sigma factor; Provisional; Region: PRK12513 208964008884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964008885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964008886 DNA binding residues [nucleotide binding] 208964008887 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 208964008888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964008889 DNA-binding site [nucleotide binding]; DNA binding site 208964008890 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964008891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964008892 homodimer interface [polypeptide binding]; other site 208964008893 catalytic residue [active] 208964008894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964008895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964008896 active site 208964008897 phosphorylation site [posttranslational modification] 208964008898 intermolecular recognition site; other site 208964008899 dimerization interface [polypeptide binding]; other site 208964008900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964008901 DNA binding residues [nucleotide binding] 208964008902 dimerization interface [polypeptide binding]; other site 208964008903 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 208964008904 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964008905 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964008906 ligand binding site [chemical binding]; other site 208964008907 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 208964008908 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964008909 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964008910 substrate binding pocket [chemical binding]; other site 208964008911 membrane-bound complex binding site; other site 208964008912 hinge residues; other site 208964008913 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 208964008914 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 208964008915 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 208964008916 active site 208964008917 SAM binding site [chemical binding]; other site 208964008918 homodimer interface [polypeptide binding]; other site 208964008919 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 208964008920 active site 208964008921 SAM binding site [chemical binding]; other site 208964008922 homodimer interface [polypeptide binding]; other site 208964008923 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 208964008924 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 208964008925 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 208964008926 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 208964008927 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 208964008928 active site 208964008929 putative homodimer interface [polypeptide binding]; other site 208964008930 SAM binding site [chemical binding]; other site 208964008931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964008932 S-adenosylmethionine binding site [chemical binding]; other site 208964008933 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 208964008934 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 208964008935 Predicted membrane protein [Function unknown]; Region: COG1971 208964008936 Domain of unknown function DUF; Region: DUF204; pfam02659 208964008937 Domain of unknown function DUF; Region: DUF204; pfam02659 208964008938 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 208964008939 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964008940 N-terminal plug; other site 208964008941 ligand-binding site [chemical binding]; other site 208964008942 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 208964008943 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 208964008944 Walker A/P-loop; other site 208964008945 ATP binding site [chemical binding]; other site 208964008946 Q-loop/lid; other site 208964008947 ABC transporter signature motif; other site 208964008948 Walker B; other site 208964008949 D-loop; other site 208964008950 H-loop/switch region; other site 208964008951 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 208964008952 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 208964008953 putative ligand binding residues [chemical binding]; other site 208964008954 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208964008955 ABC-ATPase subunit interface; other site 208964008956 dimer interface [polypeptide binding]; other site 208964008957 putative PBP binding regions; other site 208964008958 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 208964008959 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 208964008960 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964008961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964008962 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964008963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964008964 short chain dehydrogenase; Provisional; Region: PRK12744 208964008965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964008966 NAD(P) binding site [chemical binding]; other site 208964008967 active site 208964008968 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964008969 dimerization interface [polypeptide binding]; other site 208964008970 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964008971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964008972 dimer interface [polypeptide binding]; other site 208964008973 putative CheW interface [polypeptide binding]; other site 208964008974 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 208964008975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964008976 LysR substrate binding domain; Region: LysR_substrate; pfam03466 208964008977 dimerization interface [polypeptide binding]; other site 208964008978 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 208964008979 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 208964008980 metal binding site [ion binding]; metal-binding site 208964008981 putative dimer interface [polypeptide binding]; other site 208964008982 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 208964008983 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964008984 substrate binding pocket [chemical binding]; other site 208964008985 membrane-bound complex binding site; other site 208964008986 hinge residues; other site 208964008987 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 208964008988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964008989 dimer interface [polypeptide binding]; other site 208964008990 conserved gate region; other site 208964008991 putative PBP binding loops; other site 208964008992 ABC-ATPase subunit interface; other site 208964008993 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 208964008994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964008995 dimer interface [polypeptide binding]; other site 208964008996 conserved gate region; other site 208964008997 putative PBP binding loops; other site 208964008998 ABC-ATPase subunit interface; other site 208964008999 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 208964009000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964009001 Walker A/P-loop; other site 208964009002 ATP binding site [chemical binding]; other site 208964009003 Q-loop/lid; other site 208964009004 ABC transporter signature motif; other site 208964009005 Walker B; other site 208964009006 D-loop; other site 208964009007 H-loop/switch region; other site 208964009008 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964009009 LysE type translocator; Region: LysE; cl00565 208964009010 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964009011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964009012 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964009013 dimerization interface [polypeptide binding]; other site 208964009014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964009015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964009016 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 208964009017 FMN binding site [chemical binding]; other site 208964009018 active site 208964009019 substrate binding site [chemical binding]; other site 208964009020 catalytic residue [active] 208964009021 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964009022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964009023 putative substrate translocation pore; other site 208964009024 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964009025 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964009026 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964009027 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 208964009028 xanthine permease; Region: pbuX; TIGR03173 208964009029 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964009030 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 208964009031 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 208964009032 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 208964009033 PA/protease or protease-like domain interface [polypeptide binding]; other site 208964009034 active site 208964009035 metal binding site [ion binding]; metal-binding site 208964009036 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964009037 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 208964009038 dimer interface [polypeptide binding]; other site 208964009039 active site 208964009040 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 208964009041 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 208964009042 metal ion-dependent adhesion site (MIDAS); other site 208964009043 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 208964009044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964009045 Walker A motif; other site 208964009046 ATP binding site [chemical binding]; other site 208964009047 Walker B motif; other site 208964009048 arginine finger; other site 208964009049 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 208964009050 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 208964009051 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 208964009052 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 208964009053 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 208964009054 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 208964009055 Predicted integral membrane protein [Function unknown]; Region: COG5446 208964009056 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 208964009057 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 208964009058 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 208964009059 active site 208964009060 SAM binding site [chemical binding]; other site 208964009061 homodimer interface [polypeptide binding]; other site 208964009062 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964009063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964009064 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 208964009065 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 208964009066 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 208964009067 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 208964009068 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 208964009069 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 208964009070 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 208964009071 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 208964009072 Ligand binding site [chemical binding]; other site 208964009073 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 208964009074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964009075 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 208964009076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 208964009077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964009078 Radical SAM superfamily; Region: Radical_SAM; pfam04055 208964009079 FeS/SAM binding site; other site 208964009080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964009081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964009082 WHG domain; Region: WHG; pfam13305 208964009083 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 208964009084 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964009085 catalytic residue [active] 208964009086 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 208964009087 active site 208964009088 Tfp pilus assembly protein PilZ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilZ; COG3215 208964009089 DNA polymerase III subunit delta'; Validated; Region: PRK05707 208964009090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 208964009091 DNA polymerase III subunit delta'; Validated; Region: PRK08485 208964009092 thymidylate kinase; Validated; Region: tmk; PRK00698 208964009093 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 208964009094 TMP-binding site; other site 208964009095 ATP-binding site [chemical binding]; other site 208964009096 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 208964009097 dimerization interface [polypeptide binding]; other site 208964009098 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 208964009099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964009100 catalytic residue [active] 208964009101 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 208964009102 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 208964009103 dimer interface [polypeptide binding]; other site 208964009104 active site 208964009105 acyl carrier protein; Provisional; Region: acpP; PRK00982 208964009106 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 208964009107 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 208964009108 NAD(P) binding site [chemical binding]; other site 208964009109 homotetramer interface [polypeptide binding]; other site 208964009110 homodimer interface [polypeptide binding]; other site 208964009111 active site 208964009112 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 208964009113 putative phosphate acyltransferase; Provisional; Region: PRK05331 208964009114 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 208964009115 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 208964009116 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 208964009117 active site 208964009118 dimer interface [polypeptide binding]; other site 208964009119 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 208964009120 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 208964009121 tandem repeat interface [polypeptide binding]; other site 208964009122 oligomer interface [polypeptide binding]; other site 208964009123 active site residues [active] 208964009124 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 208964009125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964009126 motif II; other site 208964009127 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 208964009128 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208964009129 RNA binding surface [nucleotide binding]; other site 208964009130 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 208964009131 active site 208964009132 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 208964009133 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 208964009134 homodimer interface [polypeptide binding]; other site 208964009135 oligonucleotide binding site [chemical binding]; other site 208964009136 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 208964009137 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 208964009138 FAD binding domain; Region: FAD_binding_4; pfam01565 208964009139 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 208964009140 Low molecular weight phosphatase family; Region: LMWPc; cd00115 208964009141 active site 208964009142 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 208964009143 Ligand binding site; other site 208964009144 oligomer interface; other site 208964009145 Uncharacterized conserved protein [Function unknown]; Region: COG2835 208964009146 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 208964009147 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 208964009148 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 208964009149 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 208964009150 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 208964009151 Competence protein; Region: Competence; pfam03772 208964009152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 208964009153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 208964009154 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 208964009155 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208964009156 FtsX-like permease family; Region: FtsX; pfam02687 208964009157 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 208964009158 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208964009159 Walker A/P-loop; other site 208964009160 ATP binding site [chemical binding]; other site 208964009161 Q-loop/lid; other site 208964009162 ABC transporter signature motif; other site 208964009163 Walker B; other site 208964009164 D-loop; other site 208964009165 H-loop/switch region; other site 208964009166 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 208964009167 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208964009168 FtsX-like permease family; Region: FtsX; pfam02687 208964009169 PilZ domain; Region: PilZ; pfam07238 208964009170 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 208964009171 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 208964009172 active site 208964009173 catalytic site [active] 208964009174 metal binding site [ion binding]; metal-binding site 208964009175 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 208964009176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964009177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964009178 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 208964009179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 208964009180 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 208964009181 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 208964009182 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964009183 catalytic loop [active] 208964009184 iron binding site [ion binding]; other site 208964009185 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 208964009186 FAD binding pocket [chemical binding]; other site 208964009187 FAD binding motif [chemical binding]; other site 208964009188 phosphate binding motif [ion binding]; other site 208964009189 beta-alpha-beta structure motif; other site 208964009190 NAD binding pocket [chemical binding]; other site 208964009191 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 208964009192 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 208964009193 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 208964009194 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 208964009195 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 208964009196 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 208964009197 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 208964009198 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 208964009199 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 208964009200 aromatic amino acid transporter; Provisional; Region: PRK10238 208964009201 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964009202 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 208964009203 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 208964009204 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 208964009205 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 208964009206 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 208964009207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964009208 ATP binding site [chemical binding]; other site 208964009209 putative Mg++ binding site [ion binding]; other site 208964009210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964009211 nucleotide binding region [chemical binding]; other site 208964009212 ATP-binding site [chemical binding]; other site 208964009213 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 208964009214 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 208964009215 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 208964009216 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 208964009217 beta-hexosaminidase; Provisional; Region: PRK05337 208964009218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964009219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964009220 LexA repressor; Validated; Region: PRK00215 208964009221 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 208964009222 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 208964009223 Catalytic site [active] 208964009224 SOS-response cell division inhibitor, blocks FtsZ ring formation [Cell division and chromosome partitioning]; Region: SulA; COG5404 208964009225 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 208964009226 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 208964009227 active site 208964009228 interdomain interaction site; other site 208964009229 putative metal-binding site [ion binding]; other site 208964009230 nucleotide binding site [chemical binding]; other site 208964009231 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 208964009232 domain I; other site 208964009233 DNA binding groove [nucleotide binding] 208964009234 phosphate binding site [ion binding]; other site 208964009235 domain II; other site 208964009236 domain III; other site 208964009237 nucleotide binding site [chemical binding]; other site 208964009238 catalytic site [active] 208964009239 domain IV; other site 208964009240 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 208964009241 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 208964009242 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 208964009243 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 208964009244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4728 208964009245 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 208964009246 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964009247 dimer interface [polypeptide binding]; other site 208964009248 active site 208964009249 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 208964009250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964009251 substrate binding site [chemical binding]; other site 208964009252 oxyanion hole (OAH) forming residues; other site 208964009253 trimer interface [polypeptide binding]; other site 208964009254 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 208964009255 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964009256 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 208964009257 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964009258 Ligand Binding Site [chemical binding]; other site 208964009259 ABC transporter ATPase component; Reviewed; Region: PRK11147 208964009260 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964009261 ABC transporter; Region: ABC_tran_2; pfam12848 208964009262 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964009263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964009264 Q-loop/lid; other site 208964009265 ABC transporter signature motif; other site 208964009266 Walker B; other site 208964009267 lytic murein transglycosylase; Provisional; Region: PRK11619 208964009268 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 208964009269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964009270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964009271 catalytic residue [active] 208964009272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 208964009273 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 208964009274 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 208964009275 MOSC domain; Region: MOSC; pfam03473 208964009276 lipid kinase; Reviewed; Region: PRK13054 208964009277 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 208964009278 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 208964009279 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 208964009280 putative N- and C-terminal domain interface [polypeptide binding]; other site 208964009281 putative active site [active] 208964009282 MgATP binding site [chemical binding]; other site 208964009283 catalytic site [active] 208964009284 metal binding site [ion binding]; metal-binding site 208964009285 putative carbohydrate binding site [chemical binding]; other site 208964009286 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 208964009287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964009288 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 208964009289 FAD binding domain; Region: FAD_binding_4; pfam01565 208964009290 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 208964009291 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964009292 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964009293 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964009294 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 208964009295 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 208964009296 dimer interface [polypeptide binding]; other site 208964009297 putative functional site; other site 208964009298 putative MPT binding site; other site 208964009299 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 208964009300 MPT binding site; other site 208964009301 trimer interface [polypeptide binding]; other site 208964009302 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 208964009303 GTP binding site; other site 208964009304 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 208964009305 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 208964009306 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 208964009307 putative transcriptional regulator; Provisional; Region: PRK11640 208964009308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964009309 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964009310 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 208964009311 putative C-terminal domain interface [polypeptide binding]; other site 208964009312 putative GSH binding site (G-site) [chemical binding]; other site 208964009313 putative dimer interface [polypeptide binding]; other site 208964009314 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 208964009315 putative N-terminal domain interface [polypeptide binding]; other site 208964009316 putative dimer interface [polypeptide binding]; other site 208964009317 putative substrate binding pocket (H-site) [chemical binding]; other site 208964009318 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 208964009319 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208964009320 outer membrane porin, OprD family; Region: OprD; pfam03573 208964009321 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 208964009322 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 208964009323 Predicted membrane protein [Function unknown]; Region: COG5393 208964009324 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 208964009325 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964009326 Zn2+ binding site [ion binding]; other site 208964009327 Mg2+ binding site [ion binding]; other site 208964009328 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 208964009329 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 208964009330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964009331 dimer interface [polypeptide binding]; other site 208964009332 phosphorylation site [posttranslational modification] 208964009333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964009334 ATP binding site [chemical binding]; other site 208964009335 Mg2+ binding site [ion binding]; other site 208964009336 G-X-G motif; other site 208964009337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964009338 active site 208964009339 phosphorylation site [posttranslational modification] 208964009340 intermolecular recognition site; other site 208964009341 dimerization interface [polypeptide binding]; other site 208964009342 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964009343 putative binding surface; other site 208964009344 active site 208964009345 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964009346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964009347 active site 208964009348 phosphorylation site [posttranslational modification] 208964009349 intermolecular recognition site; other site 208964009350 dimerization interface [polypeptide binding]; other site 208964009351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964009352 DNA binding residues [nucleotide binding] 208964009353 dimerization interface [polypeptide binding]; other site 208964009354 hypothetical protein; Provisional; Region: PRK11702 208964009355 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 208964009356 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 208964009357 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 208964009358 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 208964009359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 208964009360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964009361 S-adenosylmethionine binding site [chemical binding]; other site 208964009362 Ribosome modulation factor [Translation, ribosomal structure and biogenesis]; Region: Rmf; COG3130 208964009363 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 208964009364 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 208964009365 quinone interaction residues [chemical binding]; other site 208964009366 active site 208964009367 catalytic residues [active] 208964009368 FMN binding site [chemical binding]; other site 208964009369 substrate binding site [chemical binding]; other site 208964009370 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 208964009371 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964009372 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964009373 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964009374 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 208964009375 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 208964009376 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 208964009377 putative active site [active] 208964009378 Zn binding site [ion binding]; other site 208964009379 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208964009380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964009381 non-specific DNA binding site [nucleotide binding]; other site 208964009382 salt bridge; other site 208964009383 sequence-specific DNA binding site [nucleotide binding]; other site 208964009384 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208964009385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964009386 non-specific DNA binding site [nucleotide binding]; other site 208964009387 salt bridge; other site 208964009388 sequence-specific DNA binding site [nucleotide binding]; other site 208964009389 Predicted membrane protein [Function unknown]; Region: COG4267 208964009390 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 208964009391 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964009392 HEAT repeats; Region: HEAT_2; pfam13646 208964009393 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 208964009394 GAF domain; Region: GAF_3; pfam13492 208964009395 Tetratricopeptide repeat; Region: TPR_15; pfam13429 208964009396 Uncharacterized conserved protein [Function unknown]; Region: COG3868 208964009397 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 208964009398 putative active site [active] 208964009399 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 208964009400 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 208964009401 catalytic triad [active] 208964009402 conserved cis-peptide bond; other site 208964009403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964009404 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964009405 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 208964009406 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 208964009407 MoxR-like ATPases [General function prediction only]; Region: COG0714 208964009408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964009409 Walker A motif; other site 208964009410 ATP binding site [chemical binding]; other site 208964009411 Walker B motif; other site 208964009412 arginine finger; other site 208964009413 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 208964009414 Protein of unknown function DUF58; Region: DUF58; pfam01882 208964009415 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 208964009416 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 208964009417 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 208964009418 metal ion-dependent adhesion site (MIDAS); other site 208964009419 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 208964009420 von Willebrand factor type A domain; Region: VWA_2; pfam13519 208964009421 metal ion-dependent adhesion site (MIDAS); other site 208964009422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964009423 TPR repeat; Region: TPR_11; pfam13414 208964009424 binding surface 208964009425 Oxygen tolerance; Region: BatD; pfam13584 208964009426 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964009427 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208964009428 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964009429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964009430 active site 208964009431 phosphorylation site [posttranslational modification] 208964009432 intermolecular recognition site; other site 208964009433 dimerization interface [polypeptide binding]; other site 208964009434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964009435 DNA binding site [nucleotide binding] 208964009436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964009437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964009438 dimer interface [polypeptide binding]; other site 208964009439 phosphorylation site [posttranslational modification] 208964009440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964009441 ATP binding site [chemical binding]; other site 208964009442 Mg2+ binding site [ion binding]; other site 208964009443 G-X-G motif; other site 208964009444 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 208964009445 MMPL family; Region: MMPL; cl14618 208964009446 MMPL family; Region: MMPL; cl14618 208964009447 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 208964009448 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 208964009449 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 208964009450 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 208964009451 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 208964009452 aminopeptidase N; Provisional; Region: pepN; PRK14015 208964009453 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 208964009454 active site 208964009455 Zn binding site [ion binding]; other site 208964009456 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 208964009457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 208964009458 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 208964009459 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 208964009460 active site 208964009461 metal binding site [ion binding]; metal-binding site 208964009462 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 208964009463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3782 208964009464 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 208964009465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964009466 catalytic residue [active] 208964009467 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 208964009468 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 208964009469 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 208964009470 active site 208964009471 FMN binding site [chemical binding]; other site 208964009472 2,4-decadienoyl-CoA binding site; other site 208964009473 catalytic residue [active] 208964009474 4Fe-4S cluster binding site [ion binding]; other site 208964009475 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 208964009476 active site 208964009477 catalytic triad [active] 208964009478 dimer interface [polypeptide binding]; other site 208964009479 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964009480 Domain of unknown function (DUF3381); Region: DUF3381; pfam11861 208964009481 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964009482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964009483 Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149 208964009484 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 208964009485 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 208964009486 GspL periplasmic domain; Region: GspL_C; pfam12693 208964009487 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 208964009488 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 208964009489 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 208964009490 type II secretion system protein J; Region: gspJ; TIGR01711 208964009491 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 208964009492 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 208964009493 type II secretion system protein I; Region: gspI; TIGR01707 208964009494 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 208964009495 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 208964009496 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 208964009497 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 208964009498 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 208964009499 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 208964009500 type II secretion system protein F; Region: GspF; TIGR02120 208964009501 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 208964009502 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 208964009503 type II secretion system protein E; Region: type_II_gspE; TIGR02533 208964009504 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 208964009505 Walker A motif; other site 208964009506 ATP binding site [chemical binding]; other site 208964009507 Walker B motif; other site 208964009508 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 208964009509 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 208964009510 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964009511 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964009512 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964009513 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 208964009514 oxidoreductase; Validated; Region: PRK05717 208964009515 Clostridium thermocellum A3DFK9-like, a putative carbohydrate or polyalcohol metabolizing SDR, classical (c) SDRs; Region: A3DFK9-like_SDR_c; cd09761 208964009516 NAD binding site [chemical binding]; other site 208964009517 active site 208964009518 homodimer interface [polypeptide binding]; other site 208964009519 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 208964009520 homodimer interface [polypeptide binding]; other site 208964009521 substrate-cofactor binding pocket; other site 208964009522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964009523 catalytic residue [active] 208964009524 amidophosphoribosyltransferase; Provisional; Region: PRK09246 208964009525 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 208964009526 active site 208964009527 tetramer interface [polypeptide binding]; other site 208964009528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964009529 active site 208964009530 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 208964009531 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 208964009532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 208964009533 Merozoite surface antigen 2c; Region: MSA-2c; pfam12238 208964009534 Sporulation related domain; Region: SPOR; pfam05036 208964009535 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 208964009536 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208964009537 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 208964009538 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 208964009539 active site 208964009540 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 208964009541 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 208964009542 dimerization interface 3.5A [polypeptide binding]; other site 208964009543 active site 208964009544 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 208964009545 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964009546 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 208964009547 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 208964009548 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 208964009549 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 208964009550 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 208964009551 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 208964009552 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 208964009553 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 208964009554 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964009555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964009556 S-adenosylmethionine binding site [chemical binding]; other site 208964009557 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 208964009558 substrate binding site [chemical binding]; other site 208964009559 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 208964009560 substrate binding site [chemical binding]; other site 208964009561 ligand binding site [chemical binding]; other site 208964009562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964009563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964009564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964009565 dimerization interface [polypeptide binding]; other site 208964009566 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 208964009567 homotrimer interaction site [polypeptide binding]; other site 208964009568 putative active site [active] 208964009569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964009570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964009571 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 208964009572 putative effector binding pocket; other site 208964009573 putative dimerization interface [polypeptide binding]; other site 208964009574 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 208964009575 active site 208964009576 catalytic triad [active] 208964009577 oxyanion hole [active] 208964009578 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 208964009579 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 208964009580 putative dimer interface [polypeptide binding]; other site 208964009581 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 208964009582 dimer interface [polypeptide binding]; other site 208964009583 ligand binding site [chemical binding]; other site 208964009584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 208964009585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964009586 Coenzyme A binding pocket [chemical binding]; other site 208964009587 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 208964009588 classical (c) SDRs; Region: SDR_c; cd05233 208964009589 NAD(P) binding site [chemical binding]; other site 208964009590 active site 208964009591 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 208964009592 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 208964009593 FMN binding site [chemical binding]; other site 208964009594 active site 208964009595 catalytic residues [active] 208964009596 substrate binding site [chemical binding]; other site 208964009597 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208964009598 active site 208964009599 Entner-Doudoroff aldolase; Region: eda; TIGR01182 208964009600 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 208964009601 active site 208964009602 intersubunit interface [polypeptide binding]; other site 208964009603 catalytic residue [active] 208964009604 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208964009605 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964009606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964009607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964009608 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 208964009609 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 208964009610 active site 208964009611 HIGH motif; other site 208964009612 KMSKS motif; other site 208964009613 LysR family transcriptional regulator; Provisional; Region: PRK14997 208964009614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964009615 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964009616 putative effector binding pocket; other site 208964009617 dimerization interface [polypeptide binding]; other site 208964009618 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 208964009619 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964009620 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 208964009621 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964009622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964009623 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 208964009624 putative substrate translocation pore; other site 208964009625 excinuclease ABC subunit B; Provisional; Region: PRK05298 208964009626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964009627 ATP binding site [chemical binding]; other site 208964009628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964009629 nucleotide binding region [chemical binding]; other site 208964009630 ATP-binding site [chemical binding]; other site 208964009631 Ultra-violet resistance protein B; Region: UvrB; pfam12344 208964009632 UvrB/uvrC motif; Region: UVR; pfam02151 208964009633 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 208964009634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964009635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964009636 homodimer interface [polypeptide binding]; other site 208964009637 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 208964009638 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 208964009639 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 208964009640 CoA binding domain; Region: CoA_binding; cl17356 208964009641 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 208964009642 NAD(P) binding site [chemical binding]; other site 208964009643 homodimer interface [polypeptide binding]; other site 208964009644 substrate binding site [chemical binding]; other site 208964009645 active site 208964009646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 208964009647 Integrase core domain; Region: rve; pfam00665 208964009648 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 208964009649 Mg++ binding site [ion binding]; other site 208964009650 putative catalytic motif [active] 208964009651 putative substrate binding site [chemical binding]; other site 208964009652 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208964009653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964009654 NAD(P) binding site [chemical binding]; other site 208964009655 active site 208964009656 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 208964009657 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964009658 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 208964009659 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 208964009660 active site 208964009661 homodimer interface [polypeptide binding]; other site 208964009662 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208964009663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964009664 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 208964009665 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 208964009666 Ligand Binding Site [chemical binding]; other site 208964009667 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 208964009668 substrate binding site [chemical binding]; other site 208964009669 glutamase interaction surface [polypeptide binding]; other site 208964009670 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 208964009671 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 208964009672 putative active site [active] 208964009673 oxyanion strand; other site 208964009674 catalytic triad [active] 208964009675 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 208964009676 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 208964009677 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 208964009678 inhibitor-cofactor binding pocket; inhibition site 208964009679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964009680 catalytic residue [active] 208964009681 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 208964009682 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 208964009683 putative trimer interface [polypeptide binding]; other site 208964009684 putative active site [active] 208964009685 putative substrate binding site [chemical binding]; other site 208964009686 putative CoA binding site [chemical binding]; other site 208964009687 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 208964009688 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 208964009689 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208964009690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208964009691 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 208964009692 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 208964009693 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 208964009694 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 208964009695 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 208964009696 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 208964009697 Chain length determinant protein; Region: Wzz; pfam02706 208964009698 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 208964009699 dimer interface [polypeptide binding]; other site 208964009700 DNA binding site [nucleotide binding] 208964009701 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 208964009702 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 208964009703 RNA binding site [nucleotide binding]; other site 208964009704 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 208964009705 RNA binding site [nucleotide binding]; other site 208964009706 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 208964009707 RNA binding site [nucleotide binding]; other site 208964009708 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 208964009709 RNA binding site [nucleotide binding]; other site 208964009710 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 208964009711 RNA binding site [nucleotide binding]; other site 208964009712 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 208964009713 RNA binding site [nucleotide binding]; other site 208964009714 cytidylate kinase; Provisional; Region: cmk; PRK00023 208964009715 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 208964009716 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 208964009717 active site 208964009718 CMP-binding site; other site 208964009719 The sites determining sugar specificity; other site 208964009720 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 208964009721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964009722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964009723 homodimer interface [polypeptide binding]; other site 208964009724 catalytic residue [active] 208964009725 Chorismate mutase type II; Region: CM_2; cl00693 208964009726 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 208964009727 Prephenate dehydratase; Region: PDT; pfam00800 208964009728 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 208964009729 putative L-Phe binding site [chemical binding]; other site 208964009730 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 208964009731 homodimer interface [polypeptide binding]; other site 208964009732 substrate-cofactor binding pocket; other site 208964009733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964009734 catalytic residue [active] 208964009735 DNA gyrase subunit A; Validated; Region: PRK05560 208964009736 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 208964009737 CAP-like domain; other site 208964009738 active site 208964009739 primary dimer interface [polypeptide binding]; other site 208964009740 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208964009741 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208964009742 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208964009743 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208964009744 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208964009745 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208964009746 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 208964009747 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 208964009748 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 208964009749 active site 208964009750 putative substrate binding pocket [chemical binding]; other site 208964009751 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 208964009752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964009753 S-adenosylmethionine binding site [chemical binding]; other site 208964009754 phosphoglycolate phosphatase; Provisional; Region: PRK13222 208964009755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964009756 active site 208964009757 motif I; other site 208964009758 motif II; other site 208964009759 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 208964009760 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 208964009761 NAD(P) binding site [chemical binding]; other site 208964009762 active site 208964009763 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208964009764 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 208964009765 Bacterial transcriptional regulator; Region: IclR; pfam01614 208964009766 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 208964009767 putative active site [active] 208964009768 putative metal binding site [ion binding]; other site 208964009769 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 208964009770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964009771 metal binding site [ion binding]; metal-binding site 208964009772 active site 208964009773 I-site; other site 208964009774 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 208964009775 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208964009776 RNA binding surface [nucleotide binding]; other site 208964009777 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 208964009778 probable active site [active] 208964009779 Domain of unknown function (DUF3827); Region: DUF3827; pfam12877 208964009780 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 208964009781 nudix motif; other site 208964009782 Entner-Doudoroff aldolase; Region: eda; TIGR01182 208964009783 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 208964009784 active site 208964009785 intersubunit interface [polypeptide binding]; other site 208964009786 catalytic residue [active] 208964009787 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 208964009788 putative active site [active] 208964009789 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 208964009790 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 208964009791 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 208964009792 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208964009793 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 208964009794 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208964009795 putative active site [active] 208964009796 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 208964009797 active site 208964009798 phosphate binding residues; other site 208964009799 catalytic residues [active] 208964009800 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 208964009801 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 208964009802 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 208964009803 Walker A/P-loop; other site 208964009804 ATP binding site [chemical binding]; other site 208964009805 Q-loop/lid; other site 208964009806 ABC transporter signature motif; other site 208964009807 Walker B; other site 208964009808 D-loop; other site 208964009809 H-loop/switch region; other site 208964009810 TOBE domain; Region: TOBE; pfam03459 208964009811 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 208964009812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964009813 dimer interface [polypeptide binding]; other site 208964009814 conserved gate region; other site 208964009815 putative PBP binding loops; other site 208964009816 ABC-ATPase subunit interface; other site 208964009817 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964009818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964009819 dimer interface [polypeptide binding]; other site 208964009820 conserved gate region; other site 208964009821 putative PBP binding loops; other site 208964009822 ABC-ATPase subunit interface; other site 208964009823 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 208964009824 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 208964009825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964009826 dimerization interface [polypeptide binding]; other site 208964009827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964009828 dimer interface [polypeptide binding]; other site 208964009829 phosphorylation site [posttranslational modification] 208964009830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964009831 ATP binding site [chemical binding]; other site 208964009832 Mg2+ binding site [ion binding]; other site 208964009833 G-X-G motif; other site 208964009834 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964009835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964009836 active site 208964009837 phosphorylation site [posttranslational modification] 208964009838 intermolecular recognition site; other site 208964009839 dimerization interface [polypeptide binding]; other site 208964009840 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964009841 DNA binding site [nucleotide binding] 208964009842 glucokinase; Provisional; Region: glk; PRK00292 208964009843 phosphogluconate dehydratase; Validated; Region: PRK09054 208964009844 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 208964009845 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 208964009846 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 208964009847 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 208964009848 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 208964009849 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 208964009850 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 208964009851 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 208964009852 active site 208964009853 intracellular septation protein A; Reviewed; Region: PRK00259 208964009854 YciI-like protein; Reviewed; Region: PRK11370 208964009855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964009856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964009857 active site 208964009858 phosphorylation site [posttranslational modification] 208964009859 intermolecular recognition site; other site 208964009860 dimerization interface [polypeptide binding]; other site 208964009861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964009862 DNA binding site [nucleotide binding] 208964009863 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 208964009864 dimer interface [polypeptide binding]; other site 208964009865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964009866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964009867 dimerization interface [polypeptide binding]; other site 208964009868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964009869 dimer interface [polypeptide binding]; other site 208964009870 phosphorylation site [posttranslational modification] 208964009871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964009872 ATP binding site [chemical binding]; other site 208964009873 Mg2+ binding site [ion binding]; other site 208964009874 G-X-G motif; other site 208964009875 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 208964009876 putative FMN binding site [chemical binding]; other site 208964009877 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 208964009878 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 208964009879 Cation transport protein; Region: TrkH; cl17365 208964009880 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 208964009881 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 208964009882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964009883 Walker A/P-loop; other site 208964009884 ATP binding site [chemical binding]; other site 208964009885 Q-loop/lid; other site 208964009886 ABC transporter signature motif; other site 208964009887 Walker B; other site 208964009888 D-loop; other site 208964009889 H-loop/switch region; other site 208964009890 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 208964009891 mce related protein; Region: MCE; pfam02470 208964009892 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 208964009893 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964009894 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964009895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964009896 Predicted membrane protein [Function unknown]; Region: COG4323 208964009897 MASE2 domain; Region: MASE2; pfam05230 208964009898 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 208964009899 cyclase homology domain; Region: CHD; cd07302 208964009900 nucleotidyl binding site; other site 208964009901 metal binding site [ion binding]; metal-binding site 208964009902 dimer interface [polypeptide binding]; other site 208964009903 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 208964009904 putative active site [active] 208964009905 putative metal binding site [ion binding]; other site 208964009906 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964009907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964009908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964009909 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 208964009910 dimer interface [polypeptide binding]; other site 208964009911 putative tRNA-binding site [nucleotide binding]; other site 208964009912 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964009913 EamA-like transporter family; Region: EamA; pfam00892 208964009914 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 208964009915 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964009916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964009917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964009918 dimerization interface [polypeptide binding]; other site 208964009919 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964009920 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964009921 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 208964009922 substrate binding site [chemical binding]; other site 208964009923 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208964009924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208964009925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964009926 Walker A/P-loop; other site 208964009927 ATP binding site [chemical binding]; other site 208964009928 Q-loop/lid; other site 208964009929 ABC transporter signature motif; other site 208964009930 Walker B; other site 208964009931 D-loop; other site 208964009932 H-loop/switch region; other site 208964009933 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 208964009934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 208964009935 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 208964009936 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 208964009937 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 208964009938 active site 208964009939 catalytic site [active] 208964009940 substrate binding site [chemical binding]; other site 208964009941 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 208964009942 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208964009943 ligand binding site [chemical binding]; other site 208964009944 flexible hinge region; other site 208964009945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 208964009946 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 208964009947 metal binding triad; other site 208964009948 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 208964009949 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 208964009950 Na binding site [ion binding]; other site 208964009951 Predicted membrane protein [Function unknown]; Region: COG3162 208964009952 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 208964009953 Predicted membrane protein [Function unknown]; Region: COG3205 208964009954 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 208964009955 Pirin-related protein [General function prediction only]; Region: COG1741 208964009956 Pirin; Region: Pirin; pfam02678 208964009957 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 208964009958 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 208964009959 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 208964009960 active site 208964009961 nucleophile elbow; other site 208964009962 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 208964009963 putative acyl-acceptor binding pocket; other site 208964009964 septum formation inhibitor; Reviewed; Region: minC; PRK00339 208964009965 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 208964009966 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 208964009967 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 208964009968 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 208964009969 P-loop; other site 208964009970 ADP binding residues [chemical binding]; other site 208964009971 Switch I; other site 208964009972 Switch II; other site 208964009973 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 208964009974 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 208964009975 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 208964009976 active site 208964009977 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 208964009978 active site 208964009979 metal binding site [ion binding]; metal-binding site 208964009980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208964009981 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 208964009982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964009983 DNA-binding site [nucleotide binding]; DNA binding site 208964009984 transcriptional regulator protein; Region: phnR; TIGR03337 208964009985 UTRA domain; Region: UTRA; pfam07702 208964009986 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 208964009987 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 208964009988 Sulfatase; Region: Sulfatase; cl19157 208964009989 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 208964009990 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964009991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964009992 dimer interface [polypeptide binding]; other site 208964009993 conserved gate region; other site 208964009994 putative PBP binding loops; other site 208964009995 ABC-ATPase subunit interface; other site 208964009996 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964009997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964009998 dimer interface [polypeptide binding]; other site 208964009999 conserved gate region; other site 208964010000 putative PBP binding loops; other site 208964010001 ABC-ATPase subunit interface; other site 208964010002 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 208964010003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964010004 Walker A/P-loop; other site 208964010005 ATP binding site [chemical binding]; other site 208964010006 Q-loop/lid; other site 208964010007 ABC transporter signature motif; other site 208964010008 Walker B; other site 208964010009 D-loop; other site 208964010010 H-loop/switch region; other site 208964010011 TOBE domain; Region: TOBE_2; pfam08402 208964010012 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 208964010013 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 208964010014 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 208964010015 NAD(P) binding site [chemical binding]; other site 208964010016 carboxy-terminal protease; Provisional; Region: PRK11186 208964010017 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 208964010018 protein binding site [polypeptide binding]; other site 208964010019 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 208964010020 Catalytic dyad [active] 208964010021 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 208964010022 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964010023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 208964010024 FOG: CBS domain [General function prediction only]; Region: COG0517 208964010025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964010026 metal binding site [ion binding]; metal-binding site 208964010027 active site 208964010028 I-site; other site 208964010029 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 208964010030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964010031 non-specific DNA binding site [nucleotide binding]; other site 208964010032 salt bridge; other site 208964010033 sequence-specific DNA binding site [nucleotide binding]; other site 208964010034 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 208964010035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964010036 substrate binding pocket [chemical binding]; other site 208964010037 membrane-bound complex binding site; other site 208964010038 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 208964010039 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 208964010040 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 208964010041 recombination associated protein; Reviewed; Region: rdgC; PRK00321 208964010042 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 208964010043 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 208964010044 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208964010045 DNA-binding site [nucleotide binding]; DNA binding site 208964010046 RNA-binding motif; other site 208964010047 H+ Antiporter protein; Region: 2A0121; TIGR00900 208964010048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964010049 putative substrate translocation pore; other site 208964010050 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 208964010051 putative acyl-acceptor binding pocket; other site 208964010052 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 208964010053 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964010054 N-terminal plug; other site 208964010055 ligand-binding site [chemical binding]; other site 208964010056 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964010057 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964010058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964010059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964010060 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 208964010061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208964010062 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 208964010063 Na binding site [ion binding]; other site 208964010064 PAS domain; Region: PAS; smart00091 208964010065 PAS fold; Region: PAS_7; pfam12860 208964010066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964010067 dimer interface [polypeptide binding]; other site 208964010068 phosphorylation site [posttranslational modification] 208964010069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964010070 ATP binding site [chemical binding]; other site 208964010071 Mg2+ binding site [ion binding]; other site 208964010072 G-X-G motif; other site 208964010073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964010074 active site 208964010075 phosphorylation site [posttranslational modification] 208964010076 intermolecular recognition site; other site 208964010077 dimerization interface [polypeptide binding]; other site 208964010078 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 208964010079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964010080 ATP binding site [chemical binding]; other site 208964010081 putative Mg++ binding site [ion binding]; other site 208964010082 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964010083 nucleotide binding region [chemical binding]; other site 208964010084 ATP-binding site [chemical binding]; other site 208964010085 DEAD/H associated; Region: DEAD_assoc; pfam08494 208964010086 Uncharacterized conserved protein [Function unknown]; Region: COG1742 208964010087 short chain dehydrogenase; Provisional; Region: PRK05650 208964010088 classical (c) SDRs; Region: SDR_c; cd05233 208964010089 NAD(P) binding site [chemical binding]; other site 208964010090 active site 208964010091 Fungal trichothecene efflux pump (TRI12); Region: TRI12; pfam06609 208964010092 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 208964010093 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 208964010094 Predicted membrane protein [Function unknown]; Region: COG2259 208964010095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 208964010096 Protein of unknown function (DUF692); Region: DUF692; pfam05114 208964010097 Uncharacterized low-complexity protein [Function unknown]; Region: COG3767 208964010098 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 208964010099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964010100 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964010101 DNA binding residues [nucleotide binding] 208964010102 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 208964010103 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 208964010104 dimer interface [polypeptide binding]; other site 208964010105 active site 208964010106 CoA binding pocket [chemical binding]; other site 208964010107 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 208964010108 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 208964010109 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 208964010110 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 208964010111 catalytic triad [active] 208964010112 conserved cis-peptide bond; other site 208964010113 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 208964010114 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 208964010115 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 208964010116 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 208964010117 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 208964010118 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 208964010119 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 208964010120 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964010121 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964010122 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 208964010123 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 208964010124 HIT family signature motif; other site 208964010125 catalytic residue [active] 208964010126 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 208964010127 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 208964010128 dimer interface [polypeptide binding]; other site 208964010129 active site 208964010130 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 208964010131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964010132 ATP binding site [chemical binding]; other site 208964010133 putative Mg++ binding site [ion binding]; other site 208964010134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964010135 nucleotide binding region [chemical binding]; other site 208964010136 ATP-binding site [chemical binding]; other site 208964010137 Helicase associated domain (HA2); Region: HA2; pfam04408 208964010138 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 208964010139 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 208964010140 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 208964010141 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 208964010142 acyl-activating enzyme (AAE) consensus motif; other site 208964010143 putative AMP binding site [chemical binding]; other site 208964010144 putative active site [active] 208964010145 putative CoA binding site [chemical binding]; other site 208964010146 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 208964010147 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 208964010148 acyl-activating enzyme (AAE) consensus motif; other site 208964010149 putative AMP binding site [chemical binding]; other site 208964010150 putative active site [active] 208964010151 putative CoA binding site [chemical binding]; other site 208964010152 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 208964010153 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 208964010154 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964010155 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964010156 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 208964010157 dimer interaction site [polypeptide binding]; other site 208964010158 substrate-binding tunnel; other site 208964010159 active site 208964010160 catalytic site [active] 208964010161 substrate binding site [chemical binding]; other site 208964010162 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964010163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964010164 putative substrate translocation pore; other site 208964010165 HlyD family secretion protein; Region: HlyD; pfam00529 208964010166 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964010167 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964010168 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 208964010169 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 208964010170 Fusaric acid resistance protein family; Region: FUSC; pfam04632 208964010171 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 208964010172 ATP-dependent helicase HepA; Validated; Region: PRK04914 208964010173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964010174 ATP binding site [chemical binding]; other site 208964010175 putative Mg++ binding site [ion binding]; other site 208964010176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964010177 nucleotide binding region [chemical binding]; other site 208964010178 ATP-binding site [chemical binding]; other site 208964010179 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 208964010180 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964010181 Ligand Binding Site [chemical binding]; other site 208964010182 putative metal dependent hydrolase; Provisional; Region: PRK11598 208964010183 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 208964010184 Sulfatase; Region: Sulfatase; pfam00884 208964010185 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 208964010186 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 208964010187 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 208964010188 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 208964010189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964010190 metal binding site [ion binding]; metal-binding site 208964010191 active site 208964010192 I-site; other site 208964010193 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964010194 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 208964010195 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 208964010196 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 208964010197 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 208964010198 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 208964010199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964010200 substrate binding pocket [chemical binding]; other site 208964010201 membrane-bound complex binding site; other site 208964010202 hinge residues; other site 208964010203 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 208964010204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964010205 Walker A/P-loop; other site 208964010206 ATP binding site [chemical binding]; other site 208964010207 Q-loop/lid; other site 208964010208 ABC transporter signature motif; other site 208964010209 Walker B; other site 208964010210 D-loop; other site 208964010211 H-loop/switch region; other site 208964010212 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 208964010213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964010214 dimer interface [polypeptide binding]; other site 208964010215 conserved gate region; other site 208964010216 putative PBP binding loops; other site 208964010217 ABC-ATPase subunit interface; other site 208964010218 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 208964010219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964010220 dimer interface [polypeptide binding]; other site 208964010221 conserved gate region; other site 208964010222 putative PBP binding loops; other site 208964010223 ABC-ATPase subunit interface; other site 208964010224 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 208964010225 Phosphoesterase family; Region: Phosphoesterase; pfam04185 208964010226 Domain of unknown function (DUF756); Region: DUF756; pfam05506 208964010227 Domain of unknown function (DUF756); Region: DUF756; pfam05506 208964010228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 208964010229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964010230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964010231 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 208964010232 putative substrate binding pocket [chemical binding]; other site 208964010233 putative dimerization interface [polypeptide binding]; other site 208964010234 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 208964010235 DNA binding residues [nucleotide binding] 208964010236 putative dimer interface [polypeptide binding]; other site 208964010237 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 208964010238 active site 208964010239 short chain dehydrogenase; Validated; Region: PRK05855 208964010240 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964010241 classical (c) SDRs; Region: SDR_c; cd05233 208964010242 NAD(P) binding site [chemical binding]; other site 208964010243 active site 208964010244 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 208964010245 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 208964010246 oligomer interface [polypeptide binding]; other site 208964010247 active site residues [active] 208964010248 Condensation domain; Region: Condensation; cl19241 208964010249 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 208964010250 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 208964010251 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964010252 acyl-activating enzyme (AAE) consensus motif; other site 208964010253 AMP binding site [chemical binding]; other site 208964010254 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964010255 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 208964010256 Condensation domain; Region: Condensation; cl19241 208964010257 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964010258 acyl-activating enzyme (AAE) consensus motif; other site 208964010259 AMP binding site [chemical binding]; other site 208964010260 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964010261 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 208964010262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964010263 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 208964010264 acyltransferase PapA5; Provisional; Region: PRK09294 208964010265 Condensation domain; Region: Condensation; cl19241 208964010266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964010267 short chain dehydrogenase; Provisional; Region: PRK06914 208964010268 NAD(P) binding site [chemical binding]; other site 208964010269 active site 208964010270 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 208964010271 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 208964010272 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 208964010273 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 208964010274 dimer interface [polypeptide binding]; other site 208964010275 active site 208964010276 CoA binding pocket [chemical binding]; other site 208964010277 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 208964010278 hypothetical protein; Provisional; Region: PRK08317 208964010279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964010280 S-adenosylmethionine binding site [chemical binding]; other site 208964010281 putative arabinose transporter; Provisional; Region: PRK03545 208964010282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964010283 putative substrate translocation pore; other site 208964010284 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 208964010285 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 208964010286 NADP binding site [chemical binding]; other site 208964010287 homopentamer interface [polypeptide binding]; other site 208964010288 substrate binding site [chemical binding]; other site 208964010289 active site 208964010290 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 208964010291 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 208964010292 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 208964010293 active site 208964010294 nucleophile elbow; other site 208964010295 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 208964010296 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 208964010297 Surface antigen; Region: Bac_surface_Ag; pfam01103 208964010298 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 208964010299 FimV N-terminal domain; Region: FimV_core; TIGR03505 208964010300 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; cl19576 208964010301 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 208964010302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 208964010303 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964010304 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 208964010305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964010306 metal binding site [ion binding]; metal-binding site 208964010307 active site 208964010308 I-site; other site 208964010309 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 208964010310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964010311 ATP binding site [chemical binding]; other site 208964010312 putative Mg++ binding site [ion binding]; other site 208964010313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964010314 nucleotide binding region [chemical binding]; other site 208964010315 ATP-binding site [chemical binding]; other site 208964010316 RQC domain; Region: RQC; pfam09382 208964010317 HRDC domain; Region: HRDC; pfam00570 208964010318 Helix-turn-helix domain; Region: HTH_40; pfam14493 208964010319 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964010320 putative binding surface; other site 208964010321 active site 208964010322 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964010323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964010324 active site 208964010325 phosphorylation site [posttranslational modification] 208964010326 intermolecular recognition site; other site 208964010327 dimerization interface [polypeptide binding]; other site 208964010328 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 208964010329 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 208964010330 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 208964010331 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 208964010332 anti sigma factor interaction site; other site 208964010333 regulatory phosphorylation site [posttranslational modification]; other site 208964010334 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 208964010335 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 208964010336 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 208964010337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964010338 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 208964010339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964010340 active site 208964010341 phosphorylation site [posttranslational modification] 208964010342 intermolecular recognition site; other site 208964010343 dimerization interface [polypeptide binding]; other site 208964010344 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 208964010345 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 208964010346 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 208964010347 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 208964010348 Flagellar regulator YcgR; Region: YcgR; pfam07317 208964010349 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 208964010350 PilZ domain; Region: PilZ; pfam07238 208964010351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 208964010352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964010353 putative MFS family transporter protein; Provisional; Region: PRK03633 208964010354 putative substrate translocation pore; other site 208964010355 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208964010356 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208964010357 D-serine dehydratase [Amino acid transport and metabolism]; Region: DsdA; COG3048 208964010358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964010359 catalytic residue [active] 208964010360 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964010361 EamA-like transporter family; Region: EamA; pfam00892 208964010362 EamA-like transporter family; Region: EamA; pfam00892 208964010363 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 208964010364 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 208964010365 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964010366 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964010367 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 208964010368 UreI/Amis family, subgroup 1. Putative proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like_1; cd13747 208964010369 hexamer interface [polypeptide binding]; other site 208964010370 transport channel [chemical binding]; other site 208964010371 constriction site 1 [chemical binding]; other site 208964010372 constriction site 2 [chemical binding]; other site 208964010373 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 208964010374 ANTAR domain; Region: ANTAR; pfam03861 208964010375 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 208964010376 ligand binding site [chemical binding]; other site 208964010377 regulator interaction site; other site 208964010378 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 208964010379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964010380 Walker A motif; other site 208964010381 ATP binding site [chemical binding]; other site 208964010382 Walker B motif; other site 208964010383 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 208964010384 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 208964010385 multimer interface [polypeptide binding]; other site 208964010386 active site 208964010387 catalytic triad [active] 208964010388 dimer interface [polypeptide binding]; other site 208964010389 hypothetical protein; Provisional; Region: PRK10040 208964010390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964010391 Coenzyme A binding pocket [chemical binding]; other site 208964010392 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 208964010393 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 208964010394 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 208964010395 Guanylate kinase; Region: Guanylate_kin; pfam00625 208964010396 active site 208964010397 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 208964010398 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 208964010399 active site 208964010400 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 208964010401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964010402 Walker A/P-loop; other site 208964010403 ATP binding site [chemical binding]; other site 208964010404 Q-loop/lid; other site 208964010405 ABC transporter signature motif; other site 208964010406 Walker B; other site 208964010407 D-loop; other site 208964010408 H-loop/switch region; other site 208964010409 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 208964010410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964010411 Walker A/P-loop; other site 208964010412 ATP binding site [chemical binding]; other site 208964010413 Q-loop/lid; other site 208964010414 ABC transporter signature motif; other site 208964010415 Walker B; other site 208964010416 D-loop; other site 208964010417 H-loop/switch region; other site 208964010418 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208964010419 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 208964010420 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 208964010421 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 208964010422 Phosphonate metabolizm protein PhnG; Region: PhnG; pfam06754 208964010423 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208964010424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964010425 DNA-binding site [nucleotide binding]; DNA binding site 208964010426 UTRA domain; Region: UTRA; pfam07702 208964010427 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 208964010428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964010429 dimer interface [polypeptide binding]; other site 208964010430 conserved gate region; other site 208964010431 putative PBP binding loops; other site 208964010432 ABC-ATPase subunit interface; other site 208964010433 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 208964010434 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 208964010435 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 208964010436 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 208964010437 Walker A/P-loop; other site 208964010438 ATP binding site [chemical binding]; other site 208964010439 Q-loop/lid; other site 208964010440 ABC transporter signature motif; other site 208964010441 Walker B; other site 208964010442 D-loop; other site 208964010443 H-loop/switch region; other site 208964010444 Arc-like DNA binding domain; Region: Arc; pfam03869 208964010445 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 208964010446 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 208964010447 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 208964010448 NADP binding site [chemical binding]; other site 208964010449 active site 208964010450 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 208964010451 homodimer interaction site [polypeptide binding]; other site 208964010452 cofactor binding site; other site 208964010453 Uncharacterized conserved protein [Function unknown]; Region: COG1359 208964010454 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 208964010455 active site 208964010456 metal binding site [ion binding]; metal-binding site 208964010457 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 208964010458 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 208964010459 4Fe-4S binding domain; Region: Fer4_5; pfam12801 208964010460 nitrous-oxide reductase; Validated; Region: PRK02888 208964010461 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 208964010462 The C-terminal cupredoxin domain of Nitrous-oxide reductase; Region: N2OR_C; cd04223 208964010463 dimer interface [polypeptide binding]; other site 208964010464 CuA binuclear site [ion binding]; other site 208964010465 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 208964010466 Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722 208964010467 Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722 208964010468 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 208964010469 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208964010470 Walker A/P-loop; other site 208964010471 ATP binding site [chemical binding]; other site 208964010472 Q-loop/lid; other site 208964010473 ABC transporter signature motif; other site 208964010474 Walker B; other site 208964010475 D-loop; other site 208964010476 H-loop/switch region; other site 208964010477 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 208964010478 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 208964010479 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 208964010480 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 208964010481 FAD binding pocket [chemical binding]; other site 208964010482 FAD binding motif [chemical binding]; other site 208964010483 phosphate binding motif [ion binding]; other site 208964010484 beta-alpha-beta structure motif; other site 208964010485 NAD binding pocket [chemical binding]; other site 208964010486 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 208964010487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964010488 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 208964010489 putative dimerization interface [polypeptide binding]; other site 208964010490 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 208964010491 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 208964010492 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 208964010493 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 208964010494 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 208964010495 ABC-2 type transporter; Region: ABC2_membrane; cl17235 208964010496 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964010497 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964010498 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964010499 Predicted membrane protein [Function unknown]; Region: COG3223 208964010500 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 208964010501 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 208964010502 Outer membrane efflux protein; Region: OEP; pfam02321 208964010503 Outer membrane efflux protein; Region: OEP; pfam02321 208964010504 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 208964010505 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964010506 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964010507 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 208964010508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964010509 Walker A/P-loop; other site 208964010510 ATP binding site [chemical binding]; other site 208964010511 Q-loop/lid; other site 208964010512 ABC transporter signature motif; other site 208964010513 Walker B; other site 208964010514 D-loop; other site 208964010515 H-loop/switch region; other site 208964010516 Heme-binding protein A (HasA); Region: HasA; pfam06438 208964010517 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964010518 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 208964010519 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964010520 N-terminal plug; other site 208964010521 ligand-binding site [chemical binding]; other site 208964010522 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964010523 FecR protein; Region: FecR; pfam04773 208964010524 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 208964010525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964010526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964010527 DNA binding residues [nucleotide binding] 208964010528 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 208964010529 DNA damage-inducible gene in SOS regulon, dependent on cyclic AMP and H-NS , pqiA [General function prediction only]; Region: COG3141 208964010530 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 208964010531 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 208964010532 E3 interaction surface; other site 208964010533 lipoyl attachment site [posttranslational modification]; other site 208964010534 e3 binding domain; Region: E3_binding; pfam02817 208964010535 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 208964010536 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 208964010537 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 208964010538 alpha subunit interface [polypeptide binding]; other site 208964010539 TPP binding site [chemical binding]; other site 208964010540 heterodimer interface [polypeptide binding]; other site 208964010541 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 208964010542 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 208964010543 TPP-binding site [chemical binding]; other site 208964010544 tetramer interface [polypeptide binding]; other site 208964010545 heterodimer interface [polypeptide binding]; other site 208964010546 phosphorylation loop region [posttranslational modification] 208964010547 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 208964010548 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 208964010549 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 208964010550 NAD binding site [chemical binding]; other site 208964010551 Phe binding site; other site 208964010552 Uncharacterized conserved protein [Function unknown]; Region: COG2912 208964010553 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 208964010554 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 208964010555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964010556 DNA binding residues [nucleotide binding] 208964010557 dimerization interface [polypeptide binding]; other site 208964010558 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 208964010559 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 208964010560 SnoaL-like domain; Region: SnoaL_2; pfam12680 208964010561 Helix-turn-helix domain; Region: HTH_18; pfam12833 208964010562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964010563 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964010564 FAD dependent oxidoreductase; Region: DAO; pfam01266 208964010565 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 208964010566 enoyl-CoA hydratase; Provisional; Region: PRK08259 208964010567 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964010568 substrate binding site [chemical binding]; other site 208964010569 oxyanion hole (OAH) forming residues; other site 208964010570 trimer interface [polypeptide binding]; other site 208964010571 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 208964010572 homodimer interface [polypeptide binding]; other site 208964010573 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 208964010574 NAD binding site [chemical binding]; other site 208964010575 active site 208964010576 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964010577 aldolase II superfamily protein; Provisional; Region: PRK07044 208964010578 intersubunit interface [polypeptide binding]; other site 208964010579 active site 208964010580 Zn2+ binding site [ion binding]; other site 208964010581 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 208964010582 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 208964010583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964010584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964010585 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 208964010586 putative dimerization interface [polypeptide binding]; other site 208964010587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 208964010588 Transposase; Region: DEDD_Tnp_IS110; pfam01548 208964010589 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 208964010590 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 208964010591 flavodoxin; Provisional; Region: PRK05723 208964010592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 208964010593 dihydromonapterin reductase; Provisional; Region: PRK06483 208964010594 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 208964010595 NAD(P) binding site [chemical binding]; other site 208964010596 active site 208964010597 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 208964010598 homodecamer interface [polypeptide binding]; other site 208964010599 active site 208964010600 putative catalytic site residues [active] 208964010601 zinc binding site [ion binding]; other site 208964010602 GTP-CH-I/GFRP interaction surface; other site 208964010603 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 208964010604 homooctamer interface [polypeptide binding]; other site 208964010605 active site 208964010606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 208964010607 HopJ type III effector protein; Region: HopJ; pfam08888 208964010608 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 208964010609 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 208964010610 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 208964010611 Walker A/P-loop; other site 208964010612 ATP binding site [chemical binding]; other site 208964010613 Q-loop/lid; other site 208964010614 ABC transporter signature motif; other site 208964010615 Walker B; other site 208964010616 D-loop; other site 208964010617 H-loop/switch region; other site 208964010618 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964010619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964010620 dimer interface [polypeptide binding]; other site 208964010621 conserved gate region; other site 208964010622 putative PBP binding loops; other site 208964010623 ABC-ATPase subunit interface; other site 208964010624 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 208964010625 active site 208964010626 dimer interface [polypeptide binding]; other site 208964010627 non-prolyl cis peptide bond; other site 208964010628 insertion regions; other site 208964010629 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 208964010630 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964010631 substrate binding pocket [chemical binding]; other site 208964010632 membrane-bound complex binding site; other site 208964010633 hinge residues; other site 208964010634 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 208964010635 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 208964010636 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 208964010637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964010638 Walker A/P-loop; other site 208964010639 ATP binding site [chemical binding]; other site 208964010640 Q-loop/lid; other site 208964010641 ABC transporter signature motif; other site 208964010642 Walker B; other site 208964010643 D-loop; other site 208964010644 H-loop/switch region; other site 208964010645 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964010646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964010647 dimer interface [polypeptide binding]; other site 208964010648 conserved gate region; other site 208964010649 putative PBP binding loops; other site 208964010650 ABC-ATPase subunit interface; other site 208964010651 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 208964010652 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964010653 substrate binding pocket [chemical binding]; other site 208964010654 membrane-bound complex binding site; other site 208964010655 hinge residues; other site 208964010656 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 208964010657 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 208964010658 dimer interface [polypeptide binding]; other site 208964010659 decamer (pentamer of dimers) interface [polypeptide binding]; other site 208964010660 catalytic triad [active] 208964010661 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 208964010662 malate:quinone oxidoreductase; Validated; Region: PRK05257 208964010663 Predicted dehydrogenase [General function prediction only]; Region: COG0579 208964010664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 208964010665 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 208964010666 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964010667 dimer interface [polypeptide binding]; other site 208964010668 active site 208964010669 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 208964010670 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 208964010671 Polyphosphate kinase 2 (PPK2); Region: PPK2; pfam03976 208964010672 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 208964010673 Uncharacterized conserved protein [Function unknown]; Region: COG4121 208964010674 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 208964010675 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 208964010676 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964010677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964010678 putative DNA binding site [nucleotide binding]; other site 208964010679 putative Zn2+ binding site [ion binding]; other site 208964010680 MarR family; Region: MarR_2; cl17246 208964010681 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 208964010682 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 208964010683 active site 208964010684 dimer interface [polypeptide binding]; other site 208964010685 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 208964010686 Ligand Binding Site [chemical binding]; other site 208964010687 Molecular Tunnel; other site 208964010688 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 208964010689 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208964010690 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964010691 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 208964010692 putative oligomer interface [polypeptide binding]; other site 208964010693 putative active site [active] 208964010694 metal binding site [ion binding]; metal-binding site 208964010695 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 208964010696 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 208964010697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964010698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964010699 dimer interface [polypeptide binding]; other site 208964010700 phosphorylation site [posttranslational modification] 208964010701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964010702 ATP binding site [chemical binding]; other site 208964010703 Mg2+ binding site [ion binding]; other site 208964010704 G-X-G motif; other site 208964010705 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964010706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964010707 active site 208964010708 phosphorylation site [posttranslational modification] 208964010709 intermolecular recognition site; other site 208964010710 dimerization interface [polypeptide binding]; other site 208964010711 hypothetical protein; Provisional; Region: PRK00304 208964010712 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 208964010713 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 208964010714 Transmembrane secretion effector; Region: MFS_3; pfam05977 208964010715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964010716 putative substrate translocation pore; other site 208964010717 helicase 45; Provisional; Region: PTZ00424 208964010718 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208964010719 ATP binding site [chemical binding]; other site 208964010720 Mg++ binding site [ion binding]; other site 208964010721 motif III; other site 208964010722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964010723 nucleotide binding region [chemical binding]; other site 208964010724 ATP-binding site [chemical binding]; other site 208964010725 benzoate transport; Region: 2A0115; TIGR00895 208964010726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964010727 putative substrate translocation pore; other site 208964010728 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 208964010729 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208964010730 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 208964010731 folate binding site [chemical binding]; other site 208964010732 NADP+ binding site [chemical binding]; other site 208964010733 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 208964010734 nudix motif; other site 208964010735 malate dehydrogenase; Provisional; Region: PRK13529 208964010736 Malic enzyme, N-terminal domain; Region: malic; pfam00390 208964010737 Malic enzyme, NAD binding domain; Region: Malic_M; pfam03949 208964010738 NAD(P) binding pocket [chemical binding]; other site 208964010739 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 208964010740 NlpC/P60 family; Region: NLPC_P60; pfam00877 208964010741 Predicted permeases [General function prediction only]; Region: RarD; COG2962 208964010742 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 208964010743 EamA-like transporter family; Region: EamA; pfam00892 208964010744 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 208964010745 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964010746 substrate binding pocket [chemical binding]; other site 208964010747 membrane-bound complex binding site; other site 208964010748 hinge residues; other site 208964010749 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 208964010750 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 208964010751 Autoinducer binding domain; Region: Autoind_bind; pfam03472 208964010752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964010753 DNA binding residues [nucleotide binding] 208964010754 dimerization interface [polypeptide binding]; other site 208964010755 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 208964010756 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 208964010757 homodimer interface [polypeptide binding]; other site 208964010758 active site 208964010759 TDP-binding site; other site 208964010760 acceptor substrate-binding pocket; other site 208964010761 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964010762 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 208964010763 trimer interface [polypeptide binding]; other site 208964010764 active site 208964010765 antiporter inner membrane protein; Provisional; Region: PRK11670 208964010766 Domain of unknown function DUF59; Region: DUF59; pfam01883 208964010767 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 208964010768 Walker A motif; other site 208964010769 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 208964010770 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 208964010771 active site 208964010772 HIGH motif; other site 208964010773 KMSKS motif; other site 208964010774 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 208964010775 tRNA binding surface [nucleotide binding]; other site 208964010776 anticodon binding site; other site 208964010777 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 208964010778 dimer interface [polypeptide binding]; other site 208964010779 putative tRNA-binding site [nucleotide binding]; other site 208964010780 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 208964010781 translocation protein TolB; Provisional; Region: tolB; PRK03629 208964010782 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 208964010783 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964010784 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964010785 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 208964010786 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 208964010787 putative active site [active] 208964010788 catalytic site [active] 208964010789 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 208964010790 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins; Region: PLDc_vPLD1_2_yPLD_like_2; cd09141 208964010791 putative active site [active] 208964010792 catalytic site [active] 208964010793 electron transport complex protein RsxA; Provisional; Region: PRK05151 208964010794 electron transport complex protein RnfB; Provisional; Region: PRK05113 208964010795 Putative Fe-S cluster; Region: FeS; pfam04060 208964010796 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 208964010797 electron transport complex protein RnfC; Provisional; Region: PRK05035 208964010798 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 208964010799 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 208964010800 SLBB domain; Region: SLBB; pfam10531 208964010801 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 208964010802 Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389 208964010803 electron transport complex, RnfABCDGE type, D subunit; Region: rnfD; TIGR01946 208964010804 Predicted NADH:ubiquinone oxidoreductase, subunit RnfG [Energy production and conversion]; Region: RnfG; COG4659 208964010805 electron transport complex RsxE subunit; Provisional; Region: PRK12405 208964010806 endonuclease III; Provisional; Region: PRK10702 208964010807 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 208964010808 minor groove reading motif; other site 208964010809 helix-hairpin-helix signature motif; other site 208964010810 substrate binding pocket [chemical binding]; other site 208964010811 active site 208964010812 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 208964010813 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 208964010814 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 208964010815 FMN-binding pocket [chemical binding]; other site 208964010816 flavin binding motif; other site 208964010817 phosphate binding motif [ion binding]; other site 208964010818 beta-alpha-beta structure motif; other site 208964010819 NAD binding pocket [chemical binding]; other site 208964010820 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964010821 catalytic loop [active] 208964010822 iron binding site [ion binding]; other site 208964010823 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 208964010824 homotrimer interaction site [polypeptide binding]; other site 208964010825 putative active site [active] 208964010826 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 208964010827 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 208964010828 [2Fe-2S] cluster binding site [ion binding]; other site 208964010829 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 208964010830 hydrophobic ligand binding site; other site 208964010831 aldehyde dehydrogenase family 2 member; Region: PLN02466 208964010832 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 208964010833 NAD(P) binding site [chemical binding]; other site 208964010834 catalytic residues [active] 208964010835 L-aspartate dehydrogenase; Provisional; Region: PRK13303 208964010836 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 208964010837 Domain of unknown function DUF108; Region: DUF108; pfam01958 208964010838 hypothetical protein; Provisional; Region: PRK07064 208964010839 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 208964010840 PYR/PP interface [polypeptide binding]; other site 208964010841 dimer interface [polypeptide binding]; other site 208964010842 TPP binding site [chemical binding]; other site 208964010843 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964010844 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 208964010845 TPP-binding site [chemical binding]; other site 208964010846 short chain dehydrogenase; Provisional; Region: PRK07062 208964010847 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 208964010848 putative NAD(P) binding site [chemical binding]; other site 208964010849 putative active site [active] 208964010850 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 208964010851 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208964010852 Bacterial transcriptional regulator; Region: IclR; pfam01614 208964010853 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964010854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964010855 Cupin domain; Region: Cupin_2; pfam07883 208964010856 short chain dehydrogenase; Provisional; Region: PRK12939 208964010857 classical (c) SDRs; Region: SDR_c; cd05233 208964010858 NAD(P) binding site [chemical binding]; other site 208964010859 active site 208964010860 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964010861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964010862 dimer interface [polypeptide binding]; other site 208964010863 conserved gate region; other site 208964010864 putative PBP binding loops; other site 208964010865 ABC-ATPase subunit interface; other site 208964010866 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 208964010867 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 208964010868 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 208964010869 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 208964010870 Walker A/P-loop; other site 208964010871 ATP binding site [chemical binding]; other site 208964010872 Q-loop/lid; other site 208964010873 ABC transporter signature motif; other site 208964010874 Walker B; other site 208964010875 D-loop; other site 208964010876 H-loop/switch region; other site 208964010877 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964010878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964010879 S-adenosylmethionine binding site [chemical binding]; other site 208964010880 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 208964010881 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 208964010882 tetramer interface [polypeptide binding]; other site 208964010883 active site 208964010884 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 208964010885 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 208964010886 tetramer interface [polypeptide binding]; other site 208964010887 active site 208964010888 Haem-oxygenase-associated N-terminal helices; Region: HOASN; pfam14515 208964010889 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 208964010890 Haem-oxygenase-associated N-terminal helices; Region: HOASN; pfam14515 208964010891 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 208964010892 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208964010893 metal-binding site [ion binding] 208964010894 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 208964010895 Outer membrane efflux protein; Region: OEP; pfam02321 208964010896 Outer membrane efflux protein; Region: OEP; pfam02321 208964010897 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 208964010898 MMPL family; Region: MMPL; cl14618 208964010899 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964010900 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964010901 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964010902 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 208964010903 dimer interface [polypeptide binding]; other site 208964010904 active site 208964010905 metal binding site [ion binding]; metal-binding site 208964010906 glutathione binding site [chemical binding]; other site 208964010907 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 208964010908 ANP binding site [chemical binding]; other site 208964010909 Substrate Binding Site II [chemical binding]; other site 208964010910 Substrate Binding Site I [chemical binding]; other site 208964010911 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964010912 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964010913 ligand binding site [chemical binding]; other site 208964010914 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 208964010915 active site 208964010916 substrate binding pocket [chemical binding]; other site 208964010917 dimer interface [polypeptide binding]; other site 208964010918 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 208964010919 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 208964010920 dimer interface [polypeptide binding]; other site 208964010921 catalytic site [active] 208964010922 putative active site [active] 208964010923 putative substrate binding site [chemical binding]; other site 208964010924 peroxidase; Provisional; Region: PRK15000 208964010925 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 208964010926 dimer interface [polypeptide binding]; other site 208964010927 decamer (pentamer of dimers) interface [polypeptide binding]; other site 208964010928 catalytic triad [active] 208964010929 peroxidatic and resolving cysteines [active] 208964010930 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 208964010931 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 208964010932 Ferritin-like domain; Region: Ferritin; pfam00210 208964010933 heme binding site [chemical binding]; other site 208964010934 ferroxidase pore; other site 208964010935 ferroxidase diiron center [ion binding]; other site 208964010936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964010937 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964010938 putative substrate translocation pore; other site 208964010939 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 208964010940 putative GSH binding site [chemical binding]; other site 208964010941 catalytic residues [active] 208964010942 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 208964010943 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 208964010944 putative [Fe4-S4] binding site [ion binding]; other site 208964010945 putative molybdopterin cofactor binding site [chemical binding]; other site 208964010946 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 208964010947 putative molybdopterin cofactor binding site; other site 208964010948 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 208964010949 Subtilase family; Region: Peptidase_S8; pfam00082 208964010950 catalytic triad [active] 208964010951 putative active site [active] 208964010952 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 208964010953 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 208964010954 Autotransporter beta-domain; Region: Autotransporter; smart00869 208964010955 ornithine carbamoyltransferase; Provisional; Region: PRK00779 208964010956 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 208964010957 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 208964010958 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 208964010959 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 208964010960 Walker A/P-loop; other site 208964010961 ATP binding site [chemical binding]; other site 208964010962 Q-loop/lid; other site 208964010963 ABC transporter signature motif; other site 208964010964 Walker B; other site 208964010965 D-loop; other site 208964010966 H-loop/switch region; other site 208964010967 TOBE domain; Region: TOBE_2; pfam08402 208964010968 hypothetical protein; Validated; Region: PRK02101 208964010969 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 208964010970 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 208964010971 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 208964010972 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 208964010973 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 208964010974 active site 208964010975 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 208964010976 PilZ domain; Region: PilZ; pfam07238 208964010977 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 208964010978 lipoyl-biotinyl attachment site [posttranslational modification]; other site 208964010979 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964010980 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 208964010981 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 208964010982 Sel1-like repeats; Region: SEL1; smart00671 208964010983 Alginate export; Region: Alginate_exp; pfam13372 208964010984 Right handed beta helix region; Region: Beta_helix; pfam13229 208964010985 Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722 208964010986 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 208964010987 active site 208964010988 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 208964010989 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 208964010990 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 208964010991 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 208964010992 Substrate binding site; other site 208964010993 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 208964010994 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 208964010995 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 208964010996 inhibitor-cofactor binding pocket; inhibition site 208964010997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964010998 catalytic residue [active] 208964010999 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 208964011000 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 208964011001 Ligand binding site; other site 208964011002 Putative Catalytic site; other site 208964011003 DXD motif; other site 208964011004 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 208964011005 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 208964011006 active site 208964011007 substrate binding site [chemical binding]; other site 208964011008 cosubstrate binding site; other site 208964011009 catalytic site [active] 208964011010 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 208964011011 active site 208964011012 hexamer interface [polypeptide binding]; other site 208964011013 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 208964011014 NAD binding site [chemical binding]; other site 208964011015 substrate binding site [chemical binding]; other site 208964011016 active site 208964011017 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 208964011018 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 208964011019 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 208964011020 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 208964011021 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 208964011022 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 208964011023 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 208964011024 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 208964011025 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 208964011026 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 208964011027 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 208964011028 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 208964011029 active site 208964011030 P-loop; other site 208964011031 phosphorylation site [posttranslational modification] 208964011032 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 208964011033 active site 208964011034 P-loop; other site 208964011035 phosphorylation site [posttranslational modification] 208964011036 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 208964011037 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 208964011038 putative substrate binding site [chemical binding]; other site 208964011039 putative ATP binding site [chemical binding]; other site 208964011040 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 208964011041 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208964011042 active site 208964011043 phosphorylation site [posttranslational modification] 208964011044 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 208964011045 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 208964011046 dimerization domain swap beta strand [polypeptide binding]; other site 208964011047 regulatory protein interface [polypeptide binding]; other site 208964011048 active site 208964011049 regulatory phosphorylation site [posttranslational modification]; other site 208964011050 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 208964011051 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 208964011052 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 208964011053 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 208964011054 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 208964011055 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208964011056 DNA binding site [nucleotide binding] 208964011057 domain linker motif; other site 208964011058 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 208964011059 dimerization interface [polypeptide binding]; other site 208964011060 ligand binding site [chemical binding]; other site 208964011061 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 208964011062 active site 208964011063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964011064 transcriptional activator TtdR; Provisional; Region: PRK09801 208964011065 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964011066 putative effector binding pocket; other site 208964011067 dimerization interface [polypeptide binding]; other site 208964011068 Uncharacterized conserved protein [Function unknown]; Region: COG1359 208964011069 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 208964011070 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 208964011071 putative NAD(P) binding site [chemical binding]; other site 208964011072 dimer interface [polypeptide binding]; other site 208964011073 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 208964011074 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 208964011075 acyl-activating enzyme (AAE) consensus motif; other site 208964011076 putative AMP binding site [chemical binding]; other site 208964011077 putative active site [active] 208964011078 putative CoA binding site [chemical binding]; other site 208964011079 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 208964011080 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 208964011081 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 208964011082 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 208964011083 tetrameric interface [polypeptide binding]; other site 208964011084 NAD binding site [chemical binding]; other site 208964011085 catalytic residues [active] 208964011086 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964011087 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964011088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964011089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964011090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964011091 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 208964011092 putative substrate translocation pore; other site 208964011093 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 208964011094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964011095 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 208964011096 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208964011097 metal-binding site [ion binding] 208964011098 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 208964011099 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 208964011100 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 208964011101 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 208964011102 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 208964011103 N- and C-terminal domain interface [polypeptide binding]; other site 208964011104 active site 208964011105 MgATP binding site [chemical binding]; other site 208964011106 catalytic site [active] 208964011107 metal binding site [ion binding]; metal-binding site 208964011108 glycerol binding site [chemical binding]; other site 208964011109 homotetramer interface [polypeptide binding]; other site 208964011110 homodimer interface [polypeptide binding]; other site 208964011111 FBP binding site [chemical binding]; other site 208964011112 protein IIAGlc interface [polypeptide binding]; other site 208964011113 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 208964011114 putative deacylase active site [active] 208964011115 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 208964011116 amphipathic channel; other site 208964011117 Asn-Pro-Ala signature motifs; other site 208964011118 glycerol kinase; Provisional; Region: glpK; PRK00047 208964011119 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 208964011120 N- and C-terminal domain interface [polypeptide binding]; other site 208964011121 active site 208964011122 MgATP binding site [chemical binding]; other site 208964011123 catalytic site [active] 208964011124 metal binding site [ion binding]; metal-binding site 208964011125 glycerol binding site [chemical binding]; other site 208964011126 homotetramer interface [polypeptide binding]; other site 208964011127 homodimer interface [polypeptide binding]; other site 208964011128 FBP binding site [chemical binding]; other site 208964011129 protein IIAGlc interface [polypeptide binding]; other site 208964011130 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 208964011131 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 208964011132 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 208964011133 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 208964011134 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 208964011135 GlpM protein; Region: GlpM; pfam06942 208964011136 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964011137 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964011138 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964011139 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 208964011140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964011141 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 208964011142 putative dimerization interface [polypeptide binding]; other site 208964011143 outer membrane porin, OprD family; Region: OprD; pfam03573 208964011144 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 208964011145 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964011146 dimer interface [polypeptide binding]; other site 208964011147 active site 208964011148 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 208964011149 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 208964011150 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964011151 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964011152 enoyl-CoA hydratase; Provisional; Region: PRK08138 208964011153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964011154 substrate binding site [chemical binding]; other site 208964011155 oxyanion hole (OAH) forming residues; other site 208964011156 trimer interface [polypeptide binding]; other site 208964011157 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 208964011158 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964011159 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 208964011160 active site 208964011161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964011162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964011163 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 208964011164 putative dimerization interface [polypeptide binding]; other site 208964011165 putative substrate binding pocket [chemical binding]; other site 208964011166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964011167 metabolite-proton symporter; Region: 2A0106; TIGR00883 208964011168 putative substrate translocation pore; other site 208964011169 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 208964011170 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 208964011171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964011172 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 208964011173 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 208964011174 DNA binding site [nucleotide binding] 208964011175 active site 208964011176 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208964011177 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964011178 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 208964011179 putative active site [active] 208964011180 catalytic triad [active] 208964011181 putative dimer interface [polypeptide binding]; other site 208964011182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964011183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964011184 DNA binding residues [nucleotide binding] 208964011185 dimerization interface [polypeptide binding]; other site 208964011186 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 208964011187 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 208964011188 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 208964011189 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 208964011190 active site 208964011191 FMN binding site [chemical binding]; other site 208964011192 substrate binding site [chemical binding]; other site 208964011193 3Fe-4S cluster binding site [ion binding]; other site 208964011194 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 208964011195 putative active site [active] 208964011196 trimer interface [polypeptide binding]; other site 208964011197 putative active site [active] 208964011198 Zn binding site [ion binding]; other site 208964011199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964011200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964011201 active site 208964011202 phosphorylation site [posttranslational modification] 208964011203 intermolecular recognition site; other site 208964011204 dimerization interface [polypeptide binding]; other site 208964011205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964011206 DNA binding residues [nucleotide binding] 208964011207 dimerization interface [polypeptide binding]; other site 208964011208 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964011209 EamA-like transporter family; Region: EamA; pfam00892 208964011210 EamA-like transporter family; Region: EamA; pfam00892 208964011211 Uncharacterized conserved protein [Function unknown]; Region: COG3148 208964011212 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 208964011213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964011214 Walker A/P-loop; other site 208964011215 ATP binding site [chemical binding]; other site 208964011216 Q-loop/lid; other site 208964011217 ABC transporter signature motif; other site 208964011218 Walker B; other site 208964011219 D-loop; other site 208964011220 H-loop/switch region; other site 208964011221 TOBE domain; Region: TOBE_2; pfam08402 208964011222 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964011223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964011224 dimer interface [polypeptide binding]; other site 208964011225 conserved gate region; other site 208964011226 putative PBP binding loops; other site 208964011227 ABC-ATPase subunit interface; other site 208964011228 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208964011229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964011230 dimer interface [polypeptide binding]; other site 208964011231 conserved gate region; other site 208964011232 putative PBP binding loops; other site 208964011233 ABC-ATPase subunit interface; other site 208964011234 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208964011235 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 208964011236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 208964011237 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 208964011238 XFP N-terminal domain; Region: XFP_N; pfam09364 208964011239 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 208964011240 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 208964011241 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208964011242 Beta-Casp domain; Region: Beta-Casp; smart01027 208964011243 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 208964011244 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 208964011245 recombination regulator RecX; Reviewed; Region: recX; PRK00117 208964011246 recombinase A; Provisional; Region: recA; PRK09354 208964011247 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 208964011248 hexamer interface [polypeptide binding]; other site 208964011249 Walker A motif; other site 208964011250 ATP binding site [chemical binding]; other site 208964011251 Walker B motif; other site 208964011252 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 208964011253 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 208964011254 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 208964011255 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 208964011256 MutS domain I; Region: MutS_I; pfam01624 208964011257 MutS domain II; Region: MutS_II; pfam05188 208964011258 MutS domain III; Region: MutS_III; pfam05192 208964011259 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 208964011260 Walker A/P-loop; other site 208964011261 ATP binding site [chemical binding]; other site 208964011262 Q-loop/lid; other site 208964011263 ABC transporter signature motif; other site 208964011264 Walker B; other site 208964011265 D-loop; other site 208964011266 H-loop/switch region; other site 208964011267 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 208964011268 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 208964011269 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 208964011270 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 208964011271 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 208964011272 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964011273 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 208964011274 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208964011275 DNA binding residues [nucleotide binding] 208964011276 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 208964011277 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964011278 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964011279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964011280 S-adenosylmethionine binding site [chemical binding]; other site 208964011281 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 208964011282 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 208964011283 Permutation of conserved domain; other site 208964011284 active site 208964011285 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 208964011286 homotrimer interaction site [polypeptide binding]; other site 208964011287 zinc binding site [ion binding]; other site 208964011288 CDP-binding sites; other site 208964011289 Predicted esterase [General function prediction only]; Region: COG0627 208964011290 S-formylglutathione hydrolase; Region: PLN02442 208964011291 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 208964011292 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 208964011293 substrate binding site [chemical binding]; other site 208964011294 catalytic Zn binding site [ion binding]; other site 208964011295 NAD binding site [chemical binding]; other site 208964011296 structural Zn binding site [ion binding]; other site 208964011297 dimer interface [polypeptide binding]; other site 208964011298 LysR family transcriptional regulator; Provisional; Region: PRK14997 208964011299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964011300 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 208964011301 putative effector binding pocket; other site 208964011302 putative dimerization interface [polypeptide binding]; other site 208964011303 putative inner membrane protein; Provisional; Region: PRK11099 208964011304 Predicted transporter component [General function prediction only]; Region: COG2391 208964011305 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 208964011306 CPxP motif; other site 208964011307 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 208964011308 substrate binding site; other site 208964011309 dimer interface; other site 208964011310 Septum formation initiator; Region: DivIC; cl17659 208964011311 enolase; Provisional; Region: eno; PRK00077 208964011312 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 208964011313 dimer interface [polypeptide binding]; other site 208964011314 metal binding site [ion binding]; metal-binding site 208964011315 substrate binding pocket [chemical binding]; other site 208964011316 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 208964011317 CTP synthetase; Validated; Region: pyrG; PRK05380 208964011318 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 208964011319 Catalytic site [active] 208964011320 active site 208964011321 UTP binding site [chemical binding]; other site 208964011322 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 208964011323 active site 208964011324 putative oxyanion hole; other site 208964011325 catalytic triad [active] 208964011326 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 208964011327 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 208964011328 Ligand Binding Site [chemical binding]; other site 208964011329 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 208964011330 TilS substrate binding domain; Region: TilS; pfam09179 208964011331 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 208964011332 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 208964011333 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 208964011334 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 208964011335 putative active site [active] 208964011336 putative PHP Thumb interface [polypeptide binding]; other site 208964011337 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 208964011338 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 208964011339 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 208964011340 generic binding surface II; other site 208964011341 generic binding surface I; other site 208964011342 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 208964011343 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 208964011344 RNA/DNA hybrid binding site [nucleotide binding]; other site 208964011345 active site 208964011346 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 208964011347 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 208964011348 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 208964011349 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 208964011350 active site 208964011351 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 208964011352 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 208964011353 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 208964011354 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 208964011355 trimer interface [polypeptide binding]; other site 208964011356 active site 208964011357 UDP-GlcNAc binding site [chemical binding]; other site 208964011358 lipid binding site [chemical binding]; lipid-binding site 208964011359 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 208964011360 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 208964011361 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 208964011362 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 208964011363 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 208964011364 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 208964011365 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 208964011366 Surface antigen; Region: Bac_surface_Ag; pfam01103 208964011367 zinc metallopeptidase RseP; Provisional; Region: PRK10779 208964011368 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 208964011369 active site 208964011370 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 208964011371 protein binding site [polypeptide binding]; other site 208964011372 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 208964011373 protein binding site [polypeptide binding]; other site 208964011374 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 208964011375 putative substrate binding region [chemical binding]; other site 208964011376 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 208964011377 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 208964011378 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 208964011379 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 208964011380 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 208964011381 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 208964011382 active site 208964011383 dimer interface [polypeptide binding]; other site 208964011384 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 208964011385 hinge region; other site 208964011386 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 208964011387 putative nucleotide binding site [chemical binding]; other site 208964011388 uridine monophosphate binding site [chemical binding]; other site 208964011389 homohexameric interface [polypeptide binding]; other site 208964011390 elongation factor Ts; Provisional; Region: tsf; PRK09377 208964011391 UBA/TS-N domain; Region: UBA; pfam00627 208964011392 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 208964011393 rRNA interaction site [nucleotide binding]; other site 208964011394 S8 interaction site; other site 208964011395 putative laminin-1 binding site; other site 208964011396 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 208964011397 active site 208964011398 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 208964011399 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 208964011400 metal binding triad; other site 208964011401 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 208964011402 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964011403 Zn2+ binding site [ion binding]; other site 208964011404 Mg2+ binding site [ion binding]; other site 208964011405 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 208964011406 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 208964011407 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 208964011408 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964011409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964011410 homodimer interface [polypeptide binding]; other site 208964011411 catalytic residue [active] 208964011412 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 208964011413 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 208964011414 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 208964011415 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 208964011416 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 208964011417 putative catalytic residues [active] 208964011418 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 208964011419 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 208964011420 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N; pfam14790 208964011421 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 208964011422 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 208964011423 putative trimer interface [polypeptide binding]; other site 208964011424 putative CoA binding site [chemical binding]; other site 208964011425 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 208964011426 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964011427 catalytic residue [active] 208964011428 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 208964011429 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 208964011430 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 208964011431 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 208964011432 Vicilin N terminal region; Region: Vicilin_N; pfam04702 208964011433 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 208964011434 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 208964011435 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 208964011436 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208964011437 Walker A/P-loop; other site 208964011438 ATP binding site [chemical binding]; other site 208964011439 Q-loop/lid; other site 208964011440 ABC transporter signature motif; other site 208964011441 Walker B; other site 208964011442 D-loop; other site 208964011443 H-loop/switch region; other site 208964011444 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 208964011445 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 208964011446 putative acyl-acceptor binding pocket; other site 208964011447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 208964011448 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 208964011449 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 208964011450 MMPL family; Region: MMPL; cl14618 208964011451 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964011452 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964011453 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964011454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964011455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964011456 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 208964011457 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 208964011458 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 208964011459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964011460 S-adenosylmethionine binding site [chemical binding]; other site 208964011461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 208964011462 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 208964011463 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 208964011464 tetramer interface [polypeptide binding]; other site 208964011465 active site 208964011466 Mg2+/Mn2+ binding site [ion binding]; other site 208964011467 Protein of unknown function DUF72; Region: DUF72; cl00777 208964011468 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 208964011469 Glycoprotease family; Region: Peptidase_M22; pfam00814 208964011470 adenylate kinase; Reviewed; Region: adk; PRK00279 208964011471 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 208964011472 AMP-binding site [chemical binding]; other site 208964011473 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 208964011474 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 208964011475 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 208964011476 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 208964011477 DNA binding residues [nucleotide binding] 208964011478 dimer interface [polypeptide binding]; other site 208964011479 putative metal binding site [ion binding]; other site 208964011480 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 208964011481 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208964011482 metal-binding site [ion binding] 208964011483 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208964011484 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208964011485 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 208964011486 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964011487 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208964011488 ligand binding site [chemical binding]; other site 208964011489 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 208964011490 putative ADP-ribose binding site [chemical binding]; other site 208964011491 putative active site [active] 208964011492 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 208964011493 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964011494 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208964011495 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964011496 Uncharacterized conserved protein [Function unknown]; Region: COG2013 208964011497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3930 208964011498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 208964011499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964011500 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 208964011501 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 208964011502 dimer interface [polypeptide binding]; other site 208964011503 putative anticodon binding site; other site 208964011504 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 208964011505 motif 1; other site 208964011506 active site 208964011507 motif 2; other site 208964011508 motif 3; other site 208964011509 peptide chain release factor 2; Validated; Region: prfB; PRK00578 208964011510 This domain is found in peptide chain release factors; Region: PCRF; smart00937 208964011511 RF-1 domain; Region: RF-1; pfam00472 208964011512 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 208964011513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964011514 active site 208964011515 phosphorylation site [posttranslational modification] 208964011516 intermolecular recognition site; other site 208964011517 dimerization interface [polypeptide binding]; other site 208964011518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964011519 metal binding site [ion binding]; metal-binding site 208964011520 active site 208964011521 I-site; other site 208964011522 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 208964011523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964011524 active site 208964011525 phosphorylation site [posttranslational modification] 208964011526 intermolecular recognition site; other site 208964011527 CheB methylesterase; Region: CheB_methylest; pfam01339 208964011528 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 208964011529 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964011530 putative binding surface; other site 208964011531 active site 208964011532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964011533 ATP binding site [chemical binding]; other site 208964011534 Mg2+ binding site [ion binding]; other site 208964011535 G-X-G motif; other site 208964011536 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 208964011537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964011538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964011539 active site 208964011540 phosphorylation site [posttranslational modification] 208964011541 intermolecular recognition site; other site 208964011542 dimerization interface [polypeptide binding]; other site 208964011543 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 208964011544 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 208964011545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964011546 S-adenosylmethionine binding site [chemical binding]; other site 208964011547 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 208964011548 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 208964011549 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964011550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964011551 dimerization interface [polypeptide binding]; other site 208964011552 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 208964011553 dimer interface [polypeptide binding]; other site 208964011554 putative CheW interface [polypeptide binding]; other site 208964011555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964011556 metabolite-proton symporter; Region: 2A0106; TIGR00883 208964011557 putative substrate translocation pore; other site 208964011558 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 208964011559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964011560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964011561 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 208964011562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964011563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964011564 LysR substrate binding domain; Region: LysR_substrate; pfam03466 208964011565 dimerization interface [polypeptide binding]; other site 208964011566 Protein of unknown function (DUF533); Region: DUF533; pfam04391 208964011567 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 208964011568 putative metal binding site [ion binding]; other site 208964011569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208964011570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964011571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964011572 active site 208964011573 phosphorylation site [posttranslational modification] 208964011574 intermolecular recognition site; other site 208964011575 dimerization interface [polypeptide binding]; other site 208964011576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964011577 DNA binding residues [nucleotide binding] 208964011578 dimerization interface [polypeptide binding]; other site 208964011579 WG containing repeat; Region: WG_beta_rep; pfam14903 208964011580 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 208964011581 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 208964011582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964011583 putative substrate translocation pore; other site 208964011584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964011585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964011586 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 208964011587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964011588 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 208964011589 active site 208964011590 FMN binding site [chemical binding]; other site 208964011591 substrate binding site [chemical binding]; other site 208964011592 homotetramer interface [polypeptide binding]; other site 208964011593 catalytic residue [active] 208964011594 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 208964011595 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 208964011596 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 208964011597 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 208964011598 active site 208964011599 Zn binding site [ion binding]; other site 208964011600 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 208964011601 DHH family; Region: DHH; pfam01368 208964011602 DHHA1 domain; Region: DHHA1; pfam02272 208964011603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 208964011604 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 208964011605 PLD-like domain; Region: PLDc_2; pfam13091 208964011606 putative active site [active] 208964011607 catalytic site [active] 208964011608 ATPase involved in DNA repair; Region: DUF3686; pfam12458 208964011609 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 208964011610 linker region; other site 208964011611 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 208964011612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964011613 Walker A motif; other site 208964011614 ATP binding site [chemical binding]; other site 208964011615 Walker B motif; other site 208964011616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 208964011617 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 208964011618 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 208964011619 PspA/IM30 family; Region: PspA_IM30; pfam04012 208964011620 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 208964011621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 208964011622 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 208964011623 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 208964011624 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964011625 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208964011626 threonine synthase; Validated; Region: PRK09225 208964011627 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 208964011628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964011629 catalytic residue [active] 208964011630 homoserine dehydrogenase; Provisional; Region: PRK06349 208964011631 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 208964011632 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 208964011633 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 208964011634 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 208964011635 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 208964011636 dimerization domain [polypeptide binding]; other site 208964011637 dimer interface [polypeptide binding]; other site 208964011638 catalytic residues [active] 208964011639 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 208964011640 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 208964011641 active site 208964011642 Int/Topo IB signature motif; other site 208964011643 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 208964011644 TrkA-N domain; Region: TrkA_N; pfam02254 208964011645 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 208964011646 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 208964011647 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 208964011648 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 208964011649 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 208964011650 RimM N-terminal domain; Region: RimM; pfam01782 208964011651 PRC-barrel domain; Region: PRC; pfam05239 208964011652 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 208964011653 signal recognition particle protein; Provisional; Region: PRK10867 208964011654 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 208964011655 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 208964011656 P loop; other site 208964011657 GTP binding site [chemical binding]; other site 208964011658 Signal peptide binding domain; Region: SRP_SPB; pfam02978 208964011659 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 208964011660 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 208964011661 Domain of unknown function DUF21; Region: DUF21; pfam01595 208964011662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 208964011663 Transporter associated domain; Region: CorC_HlyC; smart01091 208964011664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964011665 metabolite-proton symporter; Region: 2A0106; TIGR00883 208964011666 putative substrate translocation pore; other site 208964011667 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 208964011668 active site 208964011669 catalytic triad [active] 208964011670 oxyanion hole [active] 208964011671 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 208964011672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964011673 ATP-grasp domain; Region: ATP-grasp; pfam02222 208964011674 Predicted Fe-S protein [General function prediction only]; Region: COG3313 208964011675 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 208964011676 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 208964011677 trimer interface [polypeptide binding]; other site 208964011678 putative metal binding site [ion binding]; other site 208964011679 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 208964011680 putative active site [active] 208964011681 putative CoA binding site [chemical binding]; other site 208964011682 nudix motif; other site 208964011683 metal binding site [ion binding]; metal-binding site 208964011684 Nudix N-terminal; Region: Nudix_N_2; pfam14803 208964011685 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 208964011686 nudix motif; other site 208964011687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 208964011688 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 208964011689 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208964011690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964011691 DNA-binding site [nucleotide binding]; DNA binding site 208964011692 UTRA domain; Region: UTRA; pfam07702 208964011693 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 208964011694 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 208964011695 active site 208964011696 dimer interface [polypeptide binding]; other site 208964011697 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 208964011698 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 208964011699 dimer interface [polypeptide binding]; other site 208964011700 active site 208964011701 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 208964011702 dimer interface [polypeptide binding]; other site 208964011703 active site 208964011704 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 208964011705 HPr interaction site; other site 208964011706 glycerol kinase (GK) interaction site [polypeptide binding]; other site 208964011707 active site 208964011708 phosphorylation site [posttranslational modification] 208964011709 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 208964011710 dimerization domain swap beta strand [polypeptide binding]; other site 208964011711 regulatory protein interface [polypeptide binding]; other site 208964011712 active site 208964011713 regulatory phosphorylation site [posttranslational modification]; other site 208964011714 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 208964011715 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 208964011716 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 208964011717 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 208964011718 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208964011719 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 208964011720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208964011721 active site turn [active] 208964011722 phosphorylation site [posttranslational modification] 208964011723 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 208964011724 active site turn [active] 208964011725 phosphorylation site [posttranslational modification] 208964011726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 208964011727 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 208964011728 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 208964011729 dimerization interface [polypeptide binding]; other site 208964011730 ATP binding site [chemical binding]; other site 208964011731 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 208964011732 dimerization interface [polypeptide binding]; other site 208964011733 ATP binding site [chemical binding]; other site 208964011734 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 208964011735 putative active site [active] 208964011736 catalytic triad [active] 208964011737 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 208964011738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964011739 substrate binding pocket [chemical binding]; other site 208964011740 membrane-bound complex binding site; other site 208964011741 hinge residues; other site 208964011742 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964011743 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964011744 catalytic residue [active] 208964011745 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 208964011746 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 208964011747 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 208964011748 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 208964011749 nucleoside/Zn binding site; other site 208964011750 dimer interface [polypeptide binding]; other site 208964011751 catalytic motif [active] 208964011752 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 208964011753 The first cupredoxin domain of CumA like multicopper oxidase; Region: CuRO_1_CumA_like; cd13861 208964011754 putative Domain 2 interface [polypeptide binding]; other site 208964011755 putative Domain 3 interface [polypeptide binding]; other site 208964011756 trinuclear Cu binding site [ion binding]; other site 208964011757 Cupredoxin superfamily; Region: Cupredoxin; cl19115 208964011758 Cupredoxin superfamily; Region: Cupredoxin; cl19115 208964011759 GMP synthase; Reviewed; Region: guaA; PRK00074 208964011760 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 208964011761 AMP/PPi binding site [chemical binding]; other site 208964011762 candidate oxyanion hole; other site 208964011763 catalytic triad [active] 208964011764 potential glutamine specificity residues [chemical binding]; other site 208964011765 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 208964011766 ATP Binding subdomain [chemical binding]; other site 208964011767 Ligand Binding sites [chemical binding]; other site 208964011768 Dimerization subdomain; other site 208964011769 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 208964011770 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 208964011771 active site 208964011772 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 208964011773 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964011774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964011775 DNA binding residues [nucleotide binding] 208964011776 dimerization interface [polypeptide binding]; other site 208964011777 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 208964011778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964011779 putative substrate translocation pore; other site 208964011780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964011781 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 208964011782 active site 208964011783 Zn binding site [ion binding]; other site 208964011784 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 208964011785 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 208964011786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964011787 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 208964011788 dimerization interface [polypeptide binding]; other site 208964011789 substrate binding pocket [chemical binding]; other site 208964011790 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 208964011791 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 208964011792 generic binding surface II; other site 208964011793 generic binding surface I; other site 208964011794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964011795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964011796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964011797 dimerization interface [polypeptide binding]; other site 208964011798 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 208964011799 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 208964011800 DctM-like transporters; Region: DctM; pfam06808 208964011801 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 208964011802 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 208964011803 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 208964011804 conserved cys residue [active] 208964011805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964011806 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 208964011807 catalytic triad [active] 208964011808 conserved cis-peptide bond; other site 208964011809 AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061 208964011810 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 208964011811 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 208964011812 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208964011813 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964011814 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 208964011815 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 208964011816 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 208964011817 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 208964011818 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964011819 N-terminal plug; other site 208964011820 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 208964011821 ligand-binding site [chemical binding]; other site 208964011822 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 208964011823 2-isopropylmalate synthase; Validated; Region: PRK03739 208964011824 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 208964011825 active site 208964011826 catalytic residues [active] 208964011827 metal binding site [ion binding]; metal-binding site 208964011828 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 208964011829 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208964011830 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 208964011831 active site 208964011832 catalytic tetrad [active] 208964011833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 208964011834 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 208964011835 putative active site [active] 208964011836 catalytic triad [active] 208964011837 dimer interface [polypeptide binding]; other site 208964011838 multimer interface [polypeptide binding]; other site 208964011839 methionine aminotransferase; Validated; Region: PRK09082 208964011840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964011841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964011842 homodimer interface [polypeptide binding]; other site 208964011843 catalytic residue [active] 208964011844 GTP-binding protein Der; Reviewed; Region: PRK00093 208964011845 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 208964011846 G1 box; other site 208964011847 GTP/Mg2+ binding site [chemical binding]; other site 208964011848 Switch I region; other site 208964011849 G2 box; other site 208964011850 Switch II region; other site 208964011851 G3 box; other site 208964011852 G4 box; other site 208964011853 G5 box; other site 208964011854 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 208964011855 G1 box; other site 208964011856 GTP/Mg2+ binding site [chemical binding]; other site 208964011857 Switch I region; other site 208964011858 G2 box; other site 208964011859 G3 box; other site 208964011860 Switch II region; other site 208964011861 G4 box; other site 208964011862 G5 box; other site 208964011863 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 208964011864 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 208964011865 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 208964011866 Trp docking motif [polypeptide binding]; other site 208964011867 active site 208964011868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 208964011869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 208964011870 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 208964011871 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 208964011872 dimer interface [polypeptide binding]; other site 208964011873 motif 1; other site 208964011874 active site 208964011875 motif 2; other site 208964011876 motif 3; other site 208964011877 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 208964011878 anticodon binding site; other site 208964011879 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 208964011880 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 208964011881 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 208964011882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964011883 non-specific DNA binding site [nucleotide binding]; other site 208964011884 salt bridge; other site 208964011885 sequence-specific DNA binding site [nucleotide binding]; other site 208964011886 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 208964011887 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 208964011888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964011889 binding surface 208964011890 TPR motif; other site 208964011891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964011892 binding surface 208964011893 TPR motif; other site 208964011894 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 208964011895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964011896 FeS/SAM binding site; other site 208964011897 Nucleoside diphosphate kinase; Region: NDK; pfam00334 208964011898 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 208964011899 active site 208964011900 multimer interface [polypeptide binding]; other site 208964011901 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 208964011902 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964011903 catalytic loop [active] 208964011904 iron binding site [ion binding]; other site 208964011905 chaperone protein HscA; Provisional; Region: hscA; PRK05183 208964011906 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 208964011907 nucleotide binding site [chemical binding]; other site 208964011908 putative NEF/HSP70 interaction site [polypeptide binding]; other site 208964011909 SBD interface [polypeptide binding]; other site 208964011910 co-chaperone HscB; Provisional; Region: hscB; PRK00294 208964011911 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 208964011912 HSP70 interaction site [polypeptide binding]; other site 208964011913 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 208964011914 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 208964011915 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 208964011916 trimerization site [polypeptide binding]; other site 208964011917 active site 208964011918 cysteine desulfurase; Provisional; Region: PRK14012 208964011919 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964011920 catalytic residue [active] 208964011921 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 208964011922 Rrf2 family protein; Region: rrf2_super; TIGR00738 208964011923 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 208964011924 serine O-acetyltransferase; Region: cysE; TIGR01172 208964011925 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 208964011926 trimer interface [polypeptide binding]; other site 208964011927 active site 208964011928 substrate binding site [chemical binding]; other site 208964011929 CoA binding site [chemical binding]; other site 208964011930 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 208964011931 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 208964011932 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 208964011933 active site 208964011934 dimerization interface [polypeptide binding]; other site 208964011935 Predicted outer membrane lipoprotein [Function unknown]; Region: COG3134 208964011936 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 208964011937 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 208964011938 Protein export membrane protein; Region: SecD_SecF; pfam02355 208964011939 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 208964011940 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 208964011941 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 208964011942 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 208964011943 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 208964011944 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 208964011945 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 208964011946 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 208964011947 phage resistance protein; Provisional; Region: PRK10551 208964011948 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 208964011949 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964011950 RDD family; Region: RDD; pfam06271 208964011951 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074 208964011952 Predicted permeases [General function prediction only]; Region: COG0795 208964011953 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964011954 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964011955 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964011956 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964011957 Helix-turn-helix domain; Region: HTH_18; pfam12833 208964011958 multifunctional aminopeptidase A; Provisional; Region: PRK00913 208964011959 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 208964011960 interface (dimer of trimers) [polypeptide binding]; other site 208964011961 Substrate-binding/catalytic site; other site 208964011962 Zn-binding sites [ion binding]; other site 208964011963 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 208964011964 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 208964011965 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 208964011966 active site 208964011967 HIGH motif; other site 208964011968 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 208964011969 KMSKS motif; other site 208964011970 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 208964011971 tRNA binding surface [nucleotide binding]; other site 208964011972 anticodon binding site; other site 208964011973 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 208964011974 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 208964011975 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 208964011976 zinc binding site [ion binding]; other site 208964011977 putative ligand binding site [chemical binding]; other site 208964011978 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 208964011979 TM-ABC transporter signature motif; other site 208964011980 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 208964011981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964011982 Walker A/P-loop; other site 208964011983 ATP binding site [chemical binding]; other site 208964011984 Q-loop/lid; other site 208964011985 ABC transporter signature motif; other site 208964011986 Walker B; other site 208964011987 D-loop; other site 208964011988 H-loop/switch region; other site 208964011989 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 208964011990 transmembrane helices; other site 208964011991 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 208964011992 TrkA-C domain; Region: TrkA_C; pfam02080 208964011993 TrkA-C domain; Region: TrkA_C; pfam02080 208964011994 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 208964011995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964011996 S-adenosylmethionine binding site [chemical binding]; other site 208964011997 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 208964011998 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 208964011999 switch II binding region; other site 208964012000 Rac1 P-loop interaction site [polypeptide binding]; other site 208964012001 GTP binding residues [chemical binding]; other site 208964012002 switch I binding region; other site 208964012003 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 208964012004 active site 208964012005 conformational flexibility of ligand binding pocket; other site 208964012006 ADP-ribosylating toxin turn-turn motif; other site 208964012007 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 208964012008 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964012009 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 208964012010 C-terminal domain interface [polypeptide binding]; other site 208964012011 GSH binding site (G-site) [chemical binding]; other site 208964012012 dimer interface [polypeptide binding]; other site 208964012013 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 208964012014 dimer interface [polypeptide binding]; other site 208964012015 N-terminal domain interface [polypeptide binding]; other site 208964012016 putative substrate binding pocket (H-site) [chemical binding]; other site 208964012017 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964012018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964012019 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 208964012020 dimerization interface [polypeptide binding]; other site 208964012021 substrate binding pocket [chemical binding]; other site 208964012022 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 208964012023 catalytic triad [active] 208964012024 dimer interface [polypeptide binding]; other site 208964012025 conserved cis-peptide bond; other site 208964012026 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 208964012027 hydrophobic ligand binding site; other site 208964012028 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 208964012029 nucleoid-associated protein NdpA; Validated; Region: PRK00378 208964012030 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 208964012031 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964012032 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 208964012033 C-terminal domain interface [polypeptide binding]; other site 208964012034 GSH binding site (G-site) [chemical binding]; other site 208964012035 dimer interface [polypeptide binding]; other site 208964012036 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 208964012037 substrate binding pocket (H-site) [chemical binding]; other site 208964012038 N-terminal domain interface [polypeptide binding]; other site 208964012039 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 208964012040 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 208964012041 trimer interface [polypeptide binding]; other site 208964012042 active site 208964012043 substrate binding site [chemical binding]; other site 208964012044 CoA binding site [chemical binding]; other site 208964012045 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 208964012046 GIY-YIG motif/motif A; other site 208964012047 putative active site [active] 208964012048 putative metal binding site [ion binding]; other site 208964012049 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 208964012050 putative C-terminal domain interface [polypeptide binding]; other site 208964012051 putative GSH binding site [chemical binding]; other site 208964012052 putative dimer interface [polypeptide binding]; other site 208964012053 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 208964012054 N-terminal domain interface [polypeptide binding]; other site 208964012055 dimer interface [polypeptide binding]; other site 208964012056 substrate binding pocket (H-site) [chemical binding]; other site 208964012057 SnoaL-like domain; Region: SnoaL_2; pfam12680 208964012058 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 208964012059 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 208964012060 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 208964012061 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964012062 substrate binding pocket [chemical binding]; other site 208964012063 membrane-bound complex binding site; other site 208964012064 hinge residues; other site 208964012065 Predicted esterase [General function prediction only]; Region: COG0400 208964012066 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964012067 AMP-binding domain protein; Validated; Region: PRK07529 208964012068 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 208964012069 acyl-activating enzyme (AAE) consensus motif; other site 208964012070 putative AMP binding site [chemical binding]; other site 208964012071 putative active site [active] 208964012072 putative CoA binding site [chemical binding]; other site 208964012073 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 208964012074 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208964012075 ATP binding site [chemical binding]; other site 208964012076 Mg++ binding site [ion binding]; other site 208964012077 motif III; other site 208964012078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964012079 nucleotide binding region [chemical binding]; other site 208964012080 ATP-binding site [chemical binding]; other site 208964012081 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 208964012082 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 208964012083 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964012084 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 208964012085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 208964012086 YheO-like PAS domain; Region: PAS_6; pfam08348 208964012087 HTH domain; Region: HTH_22; pfam13309 208964012088 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 208964012089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964012090 substrate binding pocket [chemical binding]; other site 208964012091 membrane-bound complex binding site; other site 208964012092 hinge residues; other site 208964012093 Colicin-like bacteriocin tRNase domain; Region: Cloacin; pfam03515 208964012094 S-type Pyocin; Region: Pyocin_S; pfam06958 208964012095 Colicin C terminal ribonuclease domain; Region: Colicin_C; pfam12106 208964012096 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 208964012097 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 208964012098 catalytic residues [active] 208964012099 catalytic nucleophile [active] 208964012100 Presynaptic Site I dimer interface [polypeptide binding]; other site 208964012101 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 208964012102 Synaptic Flat tetramer interface [polypeptide binding]; other site 208964012103 Synaptic Site I dimer interface [polypeptide binding]; other site 208964012104 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 208964012105 DNA-binding interface [nucleotide binding]; DNA binding site 208964012106 Integrase core domain; Region: rve; pfam00665 208964012107 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 208964012108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 208964012109 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 208964012110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964012111 FeS/SAM binding site; other site 208964012112 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 208964012113 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 208964012114 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 208964012115 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 208964012116 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 208964012117 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 208964012118 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 208964012119 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 208964012120 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 208964012121 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 208964012122 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 208964012123 [4Fe-4S] binding site [ion binding]; other site 208964012124 molybdopterin cofactor binding site [chemical binding]; other site 208964012125 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 208964012126 molybdopterin cofactor binding site; other site 208964012127 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 208964012128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964012129 putative substrate translocation pore; other site 208964012130 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 208964012131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964012132 putative substrate translocation pore; other site 208964012133 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 208964012134 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 208964012135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964012136 dimerization interface [polypeptide binding]; other site 208964012137 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 208964012138 Histidine kinase; Region: HisKA_3; pfam07730 208964012139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964012140 ATP binding site [chemical binding]; other site 208964012141 Mg2+ binding site [ion binding]; other site 208964012142 G-X-G motif; other site 208964012143 transcriptional regulator NarL; Provisional; Region: PRK10651 208964012144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012145 active site 208964012146 phosphorylation site [posttranslational modification] 208964012147 intermolecular recognition site; other site 208964012148 dimerization interface [polypeptide binding]; other site 208964012149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964012150 DNA binding residues [nucleotide binding] 208964012151 dimerization interface [polypeptide binding]; other site 208964012152 Uncharacterized conserved protein [Function unknown]; Region: COG4273 208964012153 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 208964012154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964012155 S-adenosylmethionine binding site [chemical binding]; other site 208964012156 short chain dehydrogenase; Provisional; Region: PRK05693 208964012157 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 208964012158 NADP binding site [chemical binding]; other site 208964012159 active site 208964012160 steroid binding site; other site 208964012161 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 208964012162 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 208964012163 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 208964012164 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 208964012165 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 208964012166 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 208964012167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964012168 dimer interface [polypeptide binding]; other site 208964012169 conserved gate region; other site 208964012170 putative PBP binding loops; other site 208964012171 ABC-ATPase subunit interface; other site 208964012172 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 208964012173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964012174 dimer interface [polypeptide binding]; other site 208964012175 conserved gate region; other site 208964012176 putative PBP binding loops; other site 208964012177 ABC-ATPase subunit interface; other site 208964012178 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 208964012179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964012180 Walker A/P-loop; other site 208964012181 ATP binding site [chemical binding]; other site 208964012182 Q-loop/lid; other site 208964012183 ABC transporter signature motif; other site 208964012184 Walker B; other site 208964012185 D-loop; other site 208964012186 H-loop/switch region; other site 208964012187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 208964012188 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 208964012189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964012190 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964012191 Fusaric acid resistance protein family; Region: FUSC; pfam04632 208964012192 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 208964012193 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 208964012194 Outer membrane efflux protein; Region: OEP; pfam02321 208964012195 Outer membrane efflux protein; Region: OEP; pfam02321 208964012196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964012197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964012198 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964012199 putative effector binding pocket; other site 208964012200 dimerization interface [polypeptide binding]; other site 208964012201 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 208964012202 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 208964012203 dimerization interface [polypeptide binding]; other site 208964012204 ligand binding site [chemical binding]; other site 208964012205 NADP binding site [chemical binding]; other site 208964012206 catalytic site [active] 208964012207 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964012208 EamA-like transporter family; Region: EamA; pfam00892 208964012209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964012210 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964012211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964012212 RNA polymerase sigma factor; Provisional; Region: PRK12528 208964012213 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964012214 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964012215 DNA binding residues [nucleotide binding] 208964012216 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964012217 FecR protein; Region: FecR; pfam04773 208964012218 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 208964012219 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964012220 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964012221 N-terminal plug; other site 208964012222 ligand-binding site [chemical binding]; other site 208964012223 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 208964012224 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 208964012225 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 208964012226 G1 box; other site 208964012227 putative GEF interaction site [polypeptide binding]; other site 208964012228 GTP/Mg2+ binding site [chemical binding]; other site 208964012229 Switch I region; other site 208964012230 G2 box; other site 208964012231 G3 box; other site 208964012232 Switch II region; other site 208964012233 G4 box; other site 208964012234 G5 box; other site 208964012235 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 208964012236 Elongation Factor G, domain II; Region: EFG_II; pfam14492 208964012237 Uncharacterized conserved protein [Function unknown]; Region: COG4104 208964012238 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 208964012239 Restriction endonuclease fold toxin 5; Region: Tox-REase-5; pfam15648 208964012240 Immunity protein 32; Region: Imm32; pfam15579 208964012241 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 208964012242 Lamin Tail Domain; Region: LTD; pfam00932 208964012243 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 208964012244 generic binding surface I; other site 208964012245 generic binding surface II; other site 208964012246 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 208964012247 putative active site [active] 208964012248 putative catalytic site [active] 208964012249 putative Mg binding site IVb [ion binding]; other site 208964012250 putative phosphate binding site [ion binding]; other site 208964012251 putative DNA binding site [nucleotide binding]; other site 208964012252 putative Mg binding site IVa [ion binding]; other site 208964012253 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 208964012254 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 208964012255 putative active site [active] 208964012256 putative metal binding site [ion binding]; other site 208964012257 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 208964012258 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 208964012259 putative protease; Provisional; Region: PRK15447 208964012260 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 208964012261 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 208964012262 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 208964012263 dimer interface [polypeptide binding]; other site 208964012264 putative functional site; other site 208964012265 putative MPT binding site; other site 208964012266 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 208964012267 MPT binding site; other site 208964012268 trimer interface [polypeptide binding]; other site 208964012269 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 208964012270 MoaE homodimer interface [polypeptide binding]; other site 208964012271 MoaD interaction [polypeptide binding]; other site 208964012272 active site residues [active] 208964012273 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 208964012274 MoaE interaction surface [polypeptide binding]; other site 208964012275 MoeB interaction surface [polypeptide binding]; other site 208964012276 thiocarboxylated glycine; other site 208964012277 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 208964012278 trimer interface [polypeptide binding]; other site 208964012279 dimer interface [polypeptide binding]; other site 208964012280 putative active site [active] 208964012281 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 208964012282 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 208964012283 putative active site [active] 208964012284 PhoH-like protein; Region: PhoH; cl17668 208964012285 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208964012286 metal-binding site [ion binding] 208964012287 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 208964012288 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208964012289 metal-binding site [ion binding] 208964012290 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208964012291 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208964012292 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 208964012293 AAA ATPase domain; Region: AAA_16; pfam13191 208964012294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964012295 DNA binding residues [nucleotide binding] 208964012296 dimerization interface [polypeptide binding]; other site 208964012297 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 208964012298 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 208964012299 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 208964012300 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 208964012301 dimer interface [polypeptide binding]; other site 208964012302 acyl-activating enzyme (AAE) consensus motif; other site 208964012303 putative active site [active] 208964012304 AMP binding site [chemical binding]; other site 208964012305 putative CoA binding site [chemical binding]; other site 208964012306 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 208964012307 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964012308 dimer interface [polypeptide binding]; other site 208964012309 active site 208964012310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964012311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964012312 putative substrate translocation pore; other site 208964012313 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964012314 Cupin domain; Region: Cupin_2; cl17218 208964012315 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964012316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964012317 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 208964012318 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 208964012319 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 208964012320 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 208964012321 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 208964012322 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 208964012323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964012324 Walker A motif; other site 208964012325 ATP binding site [chemical binding]; other site 208964012326 Walker B motif; other site 208964012327 BCCT family transporter; Region: BCCT; cl00569 208964012328 Predicted membrane protein [Function unknown]; Region: COG1297 208964012329 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 208964012330 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 208964012331 active site 208964012332 iron coordination sites [ion binding]; other site 208964012333 substrate binding pocket [chemical binding]; other site 208964012334 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964012335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964012336 dimer interface [polypeptide binding]; other site 208964012337 conserved gate region; other site 208964012338 putative PBP binding loops; other site 208964012339 ABC-ATPase subunit interface; other site 208964012340 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 208964012341 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 208964012342 Walker A/P-loop; other site 208964012343 ATP binding site [chemical binding]; other site 208964012344 Q-loop/lid; other site 208964012345 ABC transporter signature motif; other site 208964012346 Walker B; other site 208964012347 D-loop; other site 208964012348 H-loop/switch region; other site 208964012349 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 208964012350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964012351 substrate binding pocket [chemical binding]; other site 208964012352 membrane-bound complex binding site; other site 208964012353 hinge residues; other site 208964012354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964012355 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964012356 active site 208964012357 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cd00591 208964012358 DNA binding site [nucleotide binding] 208964012359 dimer interface [polypeptide binding]; other site 208964012360 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 208964012361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964012362 active site 208964012363 motif I; other site 208964012364 motif II; other site 208964012365 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 208964012366 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 208964012367 active site 208964012368 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 208964012369 catalytic triad [active] 208964012370 dimer interface [polypeptide binding]; other site 208964012371 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 208964012372 NADPH bind site [chemical binding]; other site 208964012373 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 208964012374 putative FMN binding site [chemical binding]; other site 208964012375 NADPH bind site [chemical binding]; other site 208964012376 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208964012377 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208964012378 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208964012379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208964012380 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 208964012381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964012382 substrate binding pocket [chemical binding]; other site 208964012383 membrane-bound complex binding site; other site 208964012384 hinge residues; other site 208964012385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964012386 substrate binding pocket [chemical binding]; other site 208964012387 membrane-bound complex binding site; other site 208964012388 hinge residues; other site 208964012389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964012390 putative active site [active] 208964012391 heme pocket [chemical binding]; other site 208964012392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964012393 dimer interface [polypeptide binding]; other site 208964012394 phosphorylation site [posttranslational modification] 208964012395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964012396 ATP binding site [chemical binding]; other site 208964012397 Mg2+ binding site [ion binding]; other site 208964012398 G-X-G motif; other site 208964012399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012400 active site 208964012401 phosphorylation site [posttranslational modification] 208964012402 intermolecular recognition site; other site 208964012403 dimerization interface [polypeptide binding]; other site 208964012404 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964012405 putative binding surface; other site 208964012406 active site 208964012407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012408 active site 208964012409 phosphorylation site [posttranslational modification] 208964012410 intermolecular recognition site; other site 208964012411 dimerization interface [polypeptide binding]; other site 208964012412 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964012413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964012414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012415 active site 208964012416 phosphorylation site [posttranslational modification] 208964012417 intermolecular recognition site; other site 208964012418 dimerization interface [polypeptide binding]; other site 208964012419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964012420 DNA binding residues [nucleotide binding] 208964012421 dimerization interface [polypeptide binding]; other site 208964012422 Predicted flavoproteins [General function prediction only]; Region: COG2081 208964012423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964012424 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208964012425 DEAD-like helicases superfamily; Region: DEXDc; smart00487 208964012426 ATP binding site [chemical binding]; other site 208964012427 Mg++ binding site [ion binding]; other site 208964012428 motif III; other site 208964012429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964012430 nucleotide binding region [chemical binding]; other site 208964012431 ATP-binding site [chemical binding]; other site 208964012432 Uncharacterized conserved protein [Function unknown]; Region: COG1432 208964012433 LabA_like proteins; Region: LabA; cd10911 208964012434 putative metal binding site [ion binding]; other site 208964012435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 208964012436 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 208964012437 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 208964012438 catalytic triad [active] 208964012439 conserved cis-peptide bond; other site 208964012440 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 208964012441 active site 208964012442 dimer interface [polypeptide binding]; other site 208964012443 non-prolyl cis peptide bond; other site 208964012444 insertion regions; other site 208964012445 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 208964012446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964012447 short chain dehydrogenase; Provisional; Region: PRK06181 208964012448 NAD(P) binding site [chemical binding]; other site 208964012449 active site 208964012450 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 208964012451 putative catalytic site [active] 208964012452 putative metal binding site [ion binding]; other site 208964012453 putative phosphate binding site [ion binding]; other site 208964012454 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964012455 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 208964012456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964012457 ATP binding site [chemical binding]; other site 208964012458 putative Mg++ binding site [ion binding]; other site 208964012459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964012460 nucleotide binding region [chemical binding]; other site 208964012461 ATP-binding site [chemical binding]; other site 208964012462 Helicase associated domain (HA2); Region: HA2; pfam04408 208964012463 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 208964012464 Cation efflux family; Region: Cation_efflux; cl00316 208964012465 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964012466 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964012467 putative DNA binding site [nucleotide binding]; other site 208964012468 putative Zn2+ binding site [ion binding]; other site 208964012469 AsnC family; Region: AsnC_trans_reg; pfam01037 208964012470 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 208964012471 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 208964012472 heme-binding site [chemical binding]; other site 208964012473 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 208964012474 active site 208964012475 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 208964012476 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202 208964012477 SEC-C motif; Region: SEC-C; pfam02810 208964012478 AMP nucleosidase; Provisional; Region: PRK08292 208964012479 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 208964012480 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 208964012481 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964012482 CoenzymeA binding site [chemical binding]; other site 208964012483 subunit interaction site [polypeptide binding]; other site 208964012484 PHB binding site; other site 208964012485 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 208964012486 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964012487 active site 208964012488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964012489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964012490 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 208964012491 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208964012492 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 208964012493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964012494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964012495 dimer interface [polypeptide binding]; other site 208964012496 phosphorylation site [posttranslational modification] 208964012497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964012498 ATP binding site [chemical binding]; other site 208964012499 Mg2+ binding site [ion binding]; other site 208964012500 G-X-G motif; other site 208964012501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012502 active site 208964012503 phosphorylation site [posttranslational modification] 208964012504 intermolecular recognition site; other site 208964012505 dimerization interface [polypeptide binding]; other site 208964012506 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 208964012507 dimer interface [polypeptide binding]; other site 208964012508 substrate binding site [chemical binding]; other site 208964012509 ATP binding site [chemical binding]; other site 208964012510 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 208964012511 thiamine phosphate binding site [chemical binding]; other site 208964012512 active site 208964012513 pyrophosphate binding site [ion binding]; other site 208964012514 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 208964012515 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964012516 inhibitor-cofactor binding pocket; inhibition site 208964012517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964012518 catalytic residue [active] 208964012519 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 208964012520 Sel1-like repeats; Region: SEL1; smart00671 208964012521 Sel1-like repeats; Region: SEL1; smart00671 208964012522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4517 208964012523 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 208964012524 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 208964012525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964012526 FeS/SAM binding site; other site 208964012527 TRAM domain; Region: TRAM; pfam01938 208964012528 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 208964012529 PhoH-like protein; Region: PhoH; pfam02562 208964012530 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 208964012531 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 208964012532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 208964012533 Transporter associated domain; Region: CorC_HlyC; smart01091 208964012534 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 208964012535 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 208964012536 putative active site [active] 208964012537 catalytic triad [active] 208964012538 putative dimer interface [polypeptide binding]; other site 208964012539 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 208964012540 putative active site [active] 208964012541 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 208964012542 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 208964012543 HIGH motif; other site 208964012544 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 208964012545 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 208964012546 active site 208964012547 KMSKS motif; other site 208964012548 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 208964012549 tRNA binding surface [nucleotide binding]; other site 208964012550 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 208964012551 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 208964012552 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 208964012553 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 208964012554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 208964012555 lytic murein transglycosylase; Region: MltB_2; TIGR02283 208964012556 Transglycosylase SLT domain; Region: SLT_2; pfam13406 208964012557 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964012558 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964012559 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 208964012560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 208964012561 Transposase; Region: DEDD_Tnp_IS110; pfam01548 208964012562 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 208964012563 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 208964012564 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964012565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964012566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964012567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964012568 dimerization interface [polypeptide binding]; other site 208964012569 lipoyl synthase; Provisional; Region: PRK05481 208964012570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208964012571 FeS/SAM binding site; other site 208964012572 lipoate-protein ligase B; Provisional; Region: PRK14342 208964012573 hypothetical protein; Provisional; Region: PRK00341 208964012574 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 208964012575 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 208964012576 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 208964012577 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 208964012578 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 208964012579 Sporulation related domain; Region: SPOR; pfam05036 208964012580 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 208964012581 Transglycosylase SLT domain; Region: SLT_2; cl19381 208964012582 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964012583 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964012584 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 208964012585 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 208964012586 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 208964012587 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 208964012588 Uncharacterized conserved protein [Function unknown]; Region: COG1576 208964012589 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 208964012590 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 208964012591 active site 208964012592 (T/H)XGH motif; other site 208964012593 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 208964012594 putative catalytic cysteine [active] 208964012595 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964012596 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964012597 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 208964012598 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 208964012599 active site 208964012600 DNA binding site [nucleotide binding] 208964012601 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 208964012602 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 208964012603 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 208964012604 active site 208964012605 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 208964012606 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 208964012607 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 208964012608 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 208964012609 putative active site [active] 208964012610 putative catalytic site [active] 208964012611 MORN repeat; Region: MORN; cl14787 208964012612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 208964012613 Peptidase C13 family; Region: Peptidase_C13; pfam01650 208964012614 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 208964012615 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 208964012616 NAD binding site [chemical binding]; other site 208964012617 active site 208964012618 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5645 208964012619 aromatic acid decarboxylase; Validated; Region: PRK05920 208964012620 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 208964012621 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208964012622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208964012623 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208964012624 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 208964012625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964012626 putative active site [active] 208964012627 heme pocket [chemical binding]; other site 208964012628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964012629 Walker A motif; other site 208964012630 ATP binding site [chemical binding]; other site 208964012631 Walker B motif; other site 208964012632 arginine finger; other site 208964012633 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964012634 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 208964012635 NAD(P) binding site [chemical binding]; other site 208964012636 catalytic residues [active] 208964012637 ethanolamine permease; Region: 2A0305; TIGR00908 208964012638 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964012639 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 208964012640 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 208964012641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208964012642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964012643 Coenzyme A binding pocket [chemical binding]; other site 208964012644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964012645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964012646 substrate binding pocket [chemical binding]; other site 208964012647 membrane-bound complex binding site; other site 208964012648 hinge residues; other site 208964012649 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 208964012650 substrate binding site [chemical binding]; other site 208964012651 activation loop (A-loop); other site 208964012652 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 208964012653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228 208964012654 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 208964012655 dimer interface [polypeptide binding]; other site 208964012656 substrate binding site [chemical binding]; other site 208964012657 metal binding sites [ion binding]; metal-binding site 208964012658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964012659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012660 active site 208964012661 phosphorylation site [posttranslational modification] 208964012662 intermolecular recognition site; other site 208964012663 dimerization interface [polypeptide binding]; other site 208964012664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964012665 DNA binding site [nucleotide binding] 208964012666 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 208964012667 amphipathic channel; other site 208964012668 Asn-Pro-Ala signature motifs; other site 208964012669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 208964012670 FecR protein; Region: FecR; pfam04773 208964012671 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 208964012672 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 208964012673 PAS domain; Region: PAS; smart00091 208964012674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964012675 dimer interface [polypeptide binding]; other site 208964012676 phosphorylation site [posttranslational modification] 208964012677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964012678 ATP binding site [chemical binding]; other site 208964012679 Mg2+ binding site [ion binding]; other site 208964012680 G-X-G motif; other site 208964012681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 208964012682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208964012683 Walker A/P-loop; other site 208964012684 ATP binding site [chemical binding]; other site 208964012685 Q-loop/lid; other site 208964012686 ABC transporter signature motif; other site 208964012687 Walker B; other site 208964012688 D-loop; other site 208964012689 H-loop/switch region; other site 208964012690 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 208964012691 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 208964012692 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 208964012693 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 208964012694 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 208964012695 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 208964012696 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 208964012697 putative active site pocket [active] 208964012698 metal binding site [ion binding]; metal-binding site 208964012699 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 208964012700 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 208964012701 substrate binding pocket [chemical binding]; other site 208964012702 chain length determination region; other site 208964012703 active site lid residues [active] 208964012704 substrate-Mg2+ binding site; other site 208964012705 catalytic residues [active] 208964012706 aspartate-rich region 1; other site 208964012707 aspartate-rich region 2; other site 208964012708 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 208964012709 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 208964012710 TPP-binding site; other site 208964012711 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 208964012712 PYR/PP interface [polypeptide binding]; other site 208964012713 dimer interface [polypeptide binding]; other site 208964012714 TPP binding site [chemical binding]; other site 208964012715 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 208964012716 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 208964012717 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 208964012718 cobalamin binding residues [chemical binding]; other site 208964012719 putative BtuC binding residues; other site 208964012720 dimer interface [polypeptide binding]; other site 208964012721 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 208964012722 dimerization interface [polypeptide binding]; other site 208964012723 active site 208964012724 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 208964012725 catalytic motif [active] 208964012726 Catalytic residue [active] 208964012727 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964012728 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964012729 membrane-bound complex binding site; other site 208964012730 hinge residues; other site 208964012731 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 208964012732 tetramer interfaces [polypeptide binding]; other site 208964012733 binuclear metal-binding site [ion binding]; other site 208964012734 thiamine monophosphate kinase; Provisional; Region: PRK05731 208964012735 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 208964012736 ATP binding site [chemical binding]; other site 208964012737 dimerization interface [polypeptide binding]; other site 208964012738 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 208964012739 putative RNA binding site [nucleotide binding]; other site 208964012740 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 208964012741 homopentamer interface [polypeptide binding]; other site 208964012742 active site 208964012743 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 208964012744 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 208964012745 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 208964012746 dimerization interface [polypeptide binding]; other site 208964012747 active site 208964012748 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 208964012749 Lumazine binding domain; Region: Lum_binding; pfam00677 208964012750 Lumazine binding domain; Region: Lum_binding; pfam00677 208964012751 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 208964012752 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 208964012753 catalytic motif [active] 208964012754 Zn binding site [ion binding]; other site 208964012755 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 208964012756 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 208964012757 ATP cone domain; Region: ATP-cone; pfam03477 208964012758 Predicted methyltransferase [General function prediction only]; Region: COG3897 208964012759 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 208964012760 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 208964012761 Tetratricopeptide repeat; Region: TPR_20; pfam14561 208964012762 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 208964012763 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208964012764 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208964012765 Walker A/P-loop; other site 208964012766 ATP binding site [chemical binding]; other site 208964012767 Q-loop/lid; other site 208964012768 ABC transporter signature motif; other site 208964012769 Walker B; other site 208964012770 D-loop; other site 208964012771 H-loop/switch region; other site 208964012772 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208964012773 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 208964012774 FtsX-like permease family; Region: FtsX; pfam02687 208964012775 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 208964012776 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 208964012777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964012778 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208964012779 NAD(P) binding site [chemical binding]; other site 208964012780 active site 208964012781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964012782 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 208964012783 NAD(P) binding site [chemical binding]; other site 208964012784 active site 208964012785 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 208964012786 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 208964012787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964012788 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 208964012789 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208964012790 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 208964012791 NAD(P) binding site [chemical binding]; other site 208964012792 catalytic residues [active] 208964012793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964012794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964012795 DNA binding residues [nucleotide binding] 208964012796 dimerization interface [polypeptide binding]; other site 208964012797 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 208964012798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 208964012799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964012800 non-specific DNA binding site [nucleotide binding]; other site 208964012801 salt bridge; other site 208964012802 sequence-specific DNA binding site [nucleotide binding]; other site 208964012803 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 208964012804 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 208964012805 acyl-activating enzyme (AAE) consensus motif; other site 208964012806 AMP binding site [chemical binding]; other site 208964012807 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964012808 thioester reductase domain; Region: Thioester-redct; TIGR01746 208964012809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964012810 NAD(P) binding site [chemical binding]; other site 208964012811 active site 208964012812 short chain dehydrogenase; Provisional; Region: PRK08177 208964012813 short chain dehydrogenase; Region: adh_short; pfam00106 208964012814 NAD(P) binding site [chemical binding]; other site 208964012815 active site 208964012816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964012817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012818 active site 208964012819 phosphorylation site [posttranslational modification] 208964012820 intermolecular recognition site; other site 208964012821 dimerization interface [polypeptide binding]; other site 208964012822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964012823 DNA binding residues [nucleotide binding] 208964012824 dimerization interface [polypeptide binding]; other site 208964012825 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 208964012826 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 208964012827 haemagglutination activity domain; Region: Haemagg_act; pfam05860 208964012828 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 208964012829 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 208964012830 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 208964012831 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 208964012832 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 208964012833 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 208964012834 PapC N-terminal domain; Region: PapC_N; pfam13954 208964012835 Outer membrane usher protein; Region: Usher; pfam00577 208964012836 PapC C-terminal domain; Region: PapC_C; pfam13953 208964012837 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 208964012838 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 208964012839 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 208964012840 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 208964012841 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 208964012842 aminotransferase; Validated; Region: PRK07046 208964012843 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 208964012844 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964012845 catalytic residue [active] 208964012846 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 208964012847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964012848 NAD(P) binding site [chemical binding]; other site 208964012849 active site 208964012850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 208964012851 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 208964012852 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 208964012853 Flavin Reductases; Region: FlaRed; cl00801 208964012854 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964012855 CoenzymeA binding site [chemical binding]; other site 208964012856 subunit interaction site [polypeptide binding]; other site 208964012857 PHB binding site; other site 208964012858 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 208964012859 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964012860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964012861 Cupin domain; Region: Cupin_2; cl17218 208964012862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964012863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964012864 putative substrate translocation pore; other site 208964012865 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 208964012866 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 208964012867 putative NAD(P) binding site [chemical binding]; other site 208964012868 catalytic Zn binding site [ion binding]; other site 208964012869 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208964012870 classical (c) SDRs; Region: SDR_c; cd05233 208964012871 NAD(P) binding site [chemical binding]; other site 208964012872 active site 208964012873 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 208964012874 choline dehydrogenase; Validated; Region: PRK02106 208964012875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964012876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964012877 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 208964012878 osmolarity response regulator; Provisional; Region: ompR; PRK09468 208964012879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012880 active site 208964012881 phosphorylation site [posttranslational modification] 208964012882 intermolecular recognition site; other site 208964012883 dimerization interface [polypeptide binding]; other site 208964012884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964012885 DNA binding site [nucleotide binding] 208964012886 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 208964012887 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 208964012888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964012889 ATP binding site [chemical binding]; other site 208964012890 Mg2+ binding site [ion binding]; other site 208964012891 G-X-G motif; other site 208964012892 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 208964012893 Predicted membrane protein [Function unknown]; Region: COG2259 208964012894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 208964012895 Protein of unknown function (DUF692); Region: DUF692; pfam05114 208964012896 Uncharacterized low-complexity protein [Function unknown]; Region: COG3767 208964012897 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 208964012898 EF-hand domain pair; Region: EF-hand_7; pfam13499 208964012899 Ca2+ binding site [ion binding]; other site 208964012900 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 208964012901 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 208964012902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964012903 Zn2+ binding site [ion binding]; other site 208964012904 Mg2+ binding site [ion binding]; other site 208964012905 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964012906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964012907 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 208964012908 putative dimerization interface [polypeptide binding]; other site 208964012909 putative substrate binding pocket [chemical binding]; other site 208964012910 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 208964012911 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3614 208964012912 PAS domain S-box; Region: sensory_box; TIGR00229 208964012913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964012914 putative active site [active] 208964012915 heme pocket [chemical binding]; other site 208964012916 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 208964012917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964012918 putative active site [active] 208964012919 heme pocket [chemical binding]; other site 208964012920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964012921 putative active site [active] 208964012922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964012923 heme pocket [chemical binding]; other site 208964012924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964012925 dimer interface [polypeptide binding]; other site 208964012926 phosphorylation site [posttranslational modification] 208964012927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964012928 ATP binding site [chemical binding]; other site 208964012929 Mg2+ binding site [ion binding]; other site 208964012930 G-X-G motif; other site 208964012931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012932 active site 208964012933 phosphorylation site [posttranslational modification] 208964012934 intermolecular recognition site; other site 208964012935 dimerization interface [polypeptide binding]; other site 208964012936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964012937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964012938 active site 208964012939 phosphorylation site [posttranslational modification] 208964012940 intermolecular recognition site; other site 208964012941 dimerization interface [polypeptide binding]; other site 208964012942 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208964012943 putative binding surface; other site 208964012944 active site 208964012945 putative arabinose transporter; Provisional; Region: PRK03545 208964012946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964012947 putative substrate translocation pore; other site 208964012948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964012949 Coenzyme A binding pocket [chemical binding]; other site 208964012950 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 208964012951 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 208964012952 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 208964012953 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 208964012954 heme binding pocket [chemical binding]; other site 208964012955 heme ligand [chemical binding]; other site 208964012956 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 208964012957 PAS fold; Region: PAS_2; pfam08446 208964012958 GAF domain; Region: GAF; pfam01590 208964012959 Phytochrome region; Region: PHY; pfam00360 208964012960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964012961 dimer interface [polypeptide binding]; other site 208964012962 phosphorylation site [posttranslational modification] 208964012963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964012964 ATP binding site [chemical binding]; other site 208964012965 Mg2+ binding site [ion binding]; other site 208964012966 G-X-G motif; other site 208964012967 Predicted periplasmic protein [Function unknown]; Region: COG3904 208964012968 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 208964012969 Phosphotransferase enzyme family; Region: APH; pfam01636 208964012970 active site 208964012971 ATP binding site [chemical binding]; other site 208964012972 antibiotic binding site [chemical binding]; other site 208964012973 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 208964012974 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964012975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964012976 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 208964012977 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 208964012978 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 208964012979 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 208964012980 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 208964012981 NAD binding site [chemical binding]; other site 208964012982 catalytic residues [active] 208964012983 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 208964012984 putative active site [active] 208964012985 putative metal binding site [ion binding]; other site 208964012986 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 208964012987 putative substrate binding pocket [chemical binding]; other site 208964012988 trimer interface [polypeptide binding]; other site 208964012989 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 208964012990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964012991 putative substrate translocation pore; other site 208964012992 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 208964012993 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 208964012994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 208964012995 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 208964012996 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 208964012997 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 208964012998 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 208964012999 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 208964013000 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 208964013001 4Fe-4S binding domain; Region: Fer4_5; pfam12801 208964013002 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 208964013003 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 208964013004 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 208964013005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964013006 DNA-binding site [nucleotide binding]; DNA binding site 208964013007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964013008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964013009 homodimer interface [polypeptide binding]; other site 208964013010 catalytic residue [active] 208964013011 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 208964013012 Low-spin heme binding site [chemical binding]; other site 208964013013 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 208964013014 D-pathway; other site 208964013015 Putative water exit pathway; other site 208964013016 Binuclear center (active site) [active] 208964013017 K-pathway; other site 208964013018 Putative proton exit pathway; other site 208964013019 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 208964013020 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964013021 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 208964013022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964013023 putative substrate translocation pore; other site 208964013024 outer membrane porin, OprD family; Region: OprD; pfam03573 208964013025 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 208964013026 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 208964013027 active site 208964013028 HIGH motif; other site 208964013029 dimer interface [polypeptide binding]; other site 208964013030 KMSKS motif; other site 208964013031 S4 RNA-binding domain; Region: S4; smart00363 208964013032 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 208964013033 FAD binding domain; Region: FAD_binding_4; pfam01565 208964013034 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 208964013035 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 208964013036 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964013037 HemX; Region: HemX; cl19375 208964013038 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964013039 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 208964013040 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 208964013041 putative active site [active] 208964013042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208964013043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964013044 Walker A/P-loop; other site 208964013045 ATP binding site [chemical binding]; other site 208964013046 Q-loop/lid; other site 208964013047 ABC transporter signature motif; other site 208964013048 Walker B; other site 208964013049 D-loop; other site 208964013050 H-loop/switch region; other site 208964013051 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 208964013052 Outer membrane efflux protein; Region: OEP; pfam02321 208964013053 Outer membrane efflux protein; Region: OEP; pfam02321 208964013054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964013055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964013056 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 208964013057 putative effector binding pocket; other site 208964013058 dimerization interface [polypeptide binding]; other site 208964013059 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 208964013060 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 208964013061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964013062 Walker A motif; other site 208964013063 ATP binding site [chemical binding]; other site 208964013064 Walker B motif; other site 208964013065 arginine finger; other site 208964013066 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964013067 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208964013068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964013069 NAD(P) binding site [chemical binding]; other site 208964013070 active site 208964013071 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 208964013072 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 208964013073 tetramer interface [polypeptide binding]; other site 208964013074 TPP-binding site [chemical binding]; other site 208964013075 heterodimer interface [polypeptide binding]; other site 208964013076 phosphorylation loop region [posttranslational modification] 208964013077 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 208964013078 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 208964013079 alpha subunit interface [polypeptide binding]; other site 208964013080 TPP binding site [chemical binding]; other site 208964013081 heterodimer interface [polypeptide binding]; other site 208964013082 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 208964013083 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 208964013084 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 208964013085 E3 interaction surface; other site 208964013086 lipoyl attachment site [posttranslational modification]; other site 208964013087 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964013088 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 208964013089 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 208964013090 putative NAD(P) binding site [chemical binding]; other site 208964013091 catalytic Zn binding site [ion binding]; other site 208964013092 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 208964013093 Bacterial SH3 domain; Region: SH3_3; pfam08239 208964013094 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 208964013095 active site 208964013096 non-prolyl cis peptide bond; other site 208964013097 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964013098 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964013099 N-terminal plug; other site 208964013100 ligand-binding site [chemical binding]; other site 208964013101 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 208964013102 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208964013103 Bacterial transcriptional regulator; Region: IclR; pfam01614 208964013104 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 208964013105 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 208964013106 Walker A/P-loop; other site 208964013107 ATP binding site [chemical binding]; other site 208964013108 Q-loop/lid; other site 208964013109 ABC transporter signature motif; other site 208964013110 Walker B; other site 208964013111 D-loop; other site 208964013112 H-loop/switch region; other site 208964013113 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 208964013114 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 208964013115 siderophore binding site; other site 208964013116 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208964013117 ABC-ATPase subunit interface; other site 208964013118 dimer interface [polypeptide binding]; other site 208964013119 putative PBP binding regions; other site 208964013120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208964013121 ABC-ATPase subunit interface; other site 208964013122 dimer interface [polypeptide binding]; other site 208964013123 putative PBP binding regions; other site 208964013124 short chain dehydrogenase; Provisional; Region: PRK07577 208964013125 classical (c) SDRs; Region: SDR_c; cd05233 208964013126 NAD(P) binding site [chemical binding]; other site 208964013127 active site 208964013128 amidase; Validated; Region: PRK06565 208964013129 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 208964013130 putative active site pocket [active] 208964013131 dimerization interface [polypeptide binding]; other site 208964013132 putative catalytic residue [active] 208964013133 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 208964013134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964013135 DNA-binding site [nucleotide binding]; DNA binding site 208964013136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964013137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964013138 homodimer interface [polypeptide binding]; other site 208964013139 catalytic residue [active] 208964013140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 208964013141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964013142 Coenzyme A binding pocket [chemical binding]; other site 208964013143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208964013144 active site 208964013145 catalytic tetrad [active] 208964013146 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 208964013147 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964013148 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964013149 N-terminal plug; other site 208964013150 ligand-binding site [chemical binding]; other site 208964013151 Predicted transcriptional regulator [Transcription]; Region: COG1959 208964013152 Rrf2 family protein; Region: rrf2_super; TIGR00738 208964013153 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 208964013154 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 208964013155 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 208964013156 intracellular protease, PfpI family; Region: PfpI; TIGR01382 208964013157 proposed catalytic triad [active] 208964013158 conserved cys residue [active] 208964013159 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 208964013160 putative catalytic site [active] 208964013161 putative phosphate binding site [ion binding]; other site 208964013162 active site 208964013163 metal binding site A [ion binding]; metal-binding site 208964013164 DNA binding site [nucleotide binding] 208964013165 putative AP binding site [nucleotide binding]; other site 208964013166 putative metal binding site B [ion binding]; other site 208964013167 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 208964013168 homotrimer interaction site [polypeptide binding]; other site 208964013169 putative active site [active] 208964013170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964013171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964013172 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 208964013173 putative effector binding pocket; other site 208964013174 putative dimerization interface [polypeptide binding]; other site 208964013175 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 208964013176 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 208964013177 Uncharacterized conserved protein [Function unknown]; Region: COG3791 208964013178 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 208964013179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964013180 S-adenosylmethionine binding site [chemical binding]; other site 208964013181 outer membrane porin, OprD family; Region: OprD; pfam03573 208964013182 acetolactate synthase; Reviewed; Region: PRK08322 208964013183 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 208964013184 PYR/PP interface [polypeptide binding]; other site 208964013185 dimer interface [polypeptide binding]; other site 208964013186 TPP binding site [chemical binding]; other site 208964013187 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964013188 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 208964013189 TPP-binding site [chemical binding]; other site 208964013190 dimer interface [polypeptide binding]; other site 208964013191 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 208964013192 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 208964013193 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 208964013194 active site 208964013195 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 208964013196 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 208964013197 conserved cys residue [active] 208964013198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964013199 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 208964013200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 208964013201 DNA-binding site [nucleotide binding]; DNA binding site 208964013202 FCD domain; Region: FCD; pfam07729 208964013203 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964013204 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964013205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964013206 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 208964013207 putative substrate translocation pore; other site 208964013208 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 208964013209 inhibitor site; inhibition site 208964013210 active site 208964013211 dimer interface [polypeptide binding]; other site 208964013212 catalytic residue [active] 208964013213 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 208964013214 NAD(P) binding site [chemical binding]; other site 208964013215 catalytic residues [active] 208964013216 putative monooxygenase; Reviewed; Region: PRK07045 208964013217 Squalene epoxidase; Region: SE; cl17314 208964013218 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 208964013219 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 208964013220 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 208964013221 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208964013222 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208964013223 Walker A/P-loop; other site 208964013224 ATP binding site [chemical binding]; other site 208964013225 Q-loop/lid; other site 208964013226 ABC transporter signature motif; other site 208964013227 Walker B; other site 208964013228 D-loop; other site 208964013229 H-loop/switch region; other site 208964013230 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964013231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964013232 dimer interface [polypeptide binding]; other site 208964013233 conserved gate region; other site 208964013234 putative PBP binding loops; other site 208964013235 ABC-ATPase subunit interface; other site 208964013236 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964013237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964013238 dimer interface [polypeptide binding]; other site 208964013239 conserved gate region; other site 208964013240 putative PBP binding loops; other site 208964013241 ABC-ATPase subunit interface; other site 208964013242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964013243 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964013244 substrate binding pocket [chemical binding]; other site 208964013245 membrane-bound complex binding site; other site 208964013246 hinge residues; other site 208964013247 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 208964013248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964013249 active site 208964013250 phosphorylation site [posttranslational modification] 208964013251 intermolecular recognition site; other site 208964013252 dimerization interface [polypeptide binding]; other site 208964013253 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964013254 DNA binding residues [nucleotide binding] 208964013255 dimerization interface [polypeptide binding]; other site 208964013256 PAS domain S-box; Region: sensory_box; TIGR00229 208964013257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964013258 putative active site [active] 208964013259 heme pocket [chemical binding]; other site 208964013260 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 208964013261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964013262 putative active site [active] 208964013263 heme pocket [chemical binding]; other site 208964013264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964013265 dimer interface [polypeptide binding]; other site 208964013266 phosphorylation site [posttranslational modification] 208964013267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964013268 ATP binding site [chemical binding]; other site 208964013269 Mg2+ binding site [ion binding]; other site 208964013270 G-X-G motif; other site 208964013271 acyl-CoA synthetase; Validated; Region: PRK08162 208964013272 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 208964013273 acyl-activating enzyme (AAE) consensus motif; other site 208964013274 putative active site [active] 208964013275 AMP binding site [chemical binding]; other site 208964013276 putative CoA binding site [chemical binding]; other site 208964013277 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 208964013278 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 208964013279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964013280 active site 208964013281 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 208964013282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208964013283 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 208964013284 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 208964013285 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964013286 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 208964013287 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 208964013288 FMN binding site [chemical binding]; other site 208964013289 substrate binding site [chemical binding]; other site 208964013290 putative catalytic residue [active] 208964013291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964013292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964013293 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 208964013294 putative dimerization interface [polypeptide binding]; other site 208964013295 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 208964013296 Predicted membrane protein [Function unknown]; Region: COG2259 208964013297 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964013298 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964013299 multidrug efflux protein; Reviewed; Region: PRK09579 208964013300 MMPL family; Region: MMPL; cl14618 208964013301 MMPL family; Region: MMPL; cl14618 208964013302 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 208964013303 Outer membrane efflux protein; Region: OEP; pfam02321 208964013304 Outer membrane efflux protein; Region: OEP; pfam02321 208964013305 O-methyltransferase; Region: Methyltransf_2; pfam00891 208964013306 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 208964013307 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 208964013308 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 208964013309 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 208964013310 hydrophobic substrate binding pocket; other site 208964013311 active site 208964013312 conserved cis-peptide bond; other site 208964013313 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 208964013314 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 208964013315 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 208964013316 Glutamine amidotransferase class-I; Region: GATase; pfam00117 208964013317 glutamine binding [chemical binding]; other site 208964013318 catalytic triad [active] 208964013319 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 208964013320 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 208964013321 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 208964013322 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 208964013323 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 208964013324 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 208964013325 hypothetical protein; Provisional; Region: PRK07538 208964013326 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 208964013327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964013328 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 208964013329 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 208964013330 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964013331 N-terminal plug; other site 208964013332 ligand-binding site [chemical binding]; other site 208964013333 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208964013334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964013335 Walker A/P-loop; other site 208964013336 ATP binding site [chemical binding]; other site 208964013337 Q-loop/lid; other site 208964013338 ABC transporter signature motif; other site 208964013339 Walker B; other site 208964013340 D-loop; other site 208964013341 H-loop/switch region; other site 208964013342 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208964013343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964013344 Walker A/P-loop; other site 208964013345 ATP binding site [chemical binding]; other site 208964013346 Q-loop/lid; other site 208964013347 ABC transporter signature motif; other site 208964013348 Walker B; other site 208964013349 D-loop; other site 208964013350 H-loop/switch region; other site 208964013351 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 208964013352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208964013353 Condensation domain; Region: Condensation; cl19241 208964013354 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 208964013355 Nonribosomal peptide synthase; Region: NRPS; pfam08415 208964013356 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 208964013357 acyl-activating enzyme (AAE) consensus motif; other site 208964013358 active site 208964013359 AMP binding site [chemical binding]; other site 208964013360 CoA binding site [chemical binding]; other site 208964013361 Methyltransferase domain; Region: Methyltransf_12; pfam08242 208964013362 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 208964013363 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964013364 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964013365 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 208964013366 Condensation domain; Region: Condensation; cl19241 208964013367 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 208964013368 Nonribosomal peptide synthase; Region: NRPS; pfam08415 208964013369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 208964013370 acyl-activating enzyme (AAE) consensus motif; other site 208964013371 active site 208964013372 AMP binding site [chemical binding]; other site 208964013373 CoA binding site [chemical binding]; other site 208964013374 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 208964013375 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 208964013376 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964013377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964013378 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 208964013379 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 208964013380 acyl-activating enzyme (AAE) consensus motif; other site 208964013381 active site 208964013382 AMP binding site [chemical binding]; other site 208964013383 substrate binding site [chemical binding]; other site 208964013384 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 208964013385 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208964013386 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 208964013387 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 208964013388 isochorismate synthases; Region: isochor_syn; TIGR00543 208964013389 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 208964013390 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 208964013391 dimer interface [polypeptide binding]; other site 208964013392 ssDNA binding site [nucleotide binding]; other site 208964013393 tetramer (dimer of dimers) interface [polypeptide binding]; other site 208964013394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964013395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964013396 putative substrate translocation pore; other site 208964013397 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 208964013398 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 208964013399 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 208964013400 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 208964013401 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 208964013402 Ferritin-like domain; Region: Ferritin; pfam00210 208964013403 heme binding site [chemical binding]; other site 208964013404 ferroxidase pore; other site 208964013405 ferroxidase diiron center [ion binding]; other site 208964013406 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 208964013407 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 208964013408 tetramer interface [polypeptide binding]; other site 208964013409 heme binding pocket [chemical binding]; other site 208964013410 NADPH binding site [chemical binding]; other site 208964013411 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 208964013412 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 208964013413 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 208964013414 alphaNTD homodimer interface [polypeptide binding]; other site 208964013415 alphaNTD - beta interaction site [polypeptide binding]; other site 208964013416 alphaNTD - beta' interaction site [polypeptide binding]; other site 208964013417 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 208964013418 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 208964013419 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 208964013420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208964013421 RNA binding surface [nucleotide binding]; other site 208964013422 30S ribosomal protein S11; Validated; Region: PRK05309 208964013423 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 208964013424 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 208964013425 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 208964013426 SecY translocase; Region: SecY; pfam00344 208964013427 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 208964013428 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 208964013429 23S rRNA binding site [nucleotide binding]; other site 208964013430 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 208964013431 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 208964013432 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 208964013433 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 208964013434 5S rRNA interface [nucleotide binding]; other site 208964013435 23S rRNA interface [nucleotide binding]; other site 208964013436 L5 interface [polypeptide binding]; other site 208964013437 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 208964013438 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 208964013439 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 208964013440 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 208964013441 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 208964013442 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 208964013443 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 208964013444 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 208964013445 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 208964013446 RNA binding site [nucleotide binding]; other site 208964013447 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 208964013448 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 208964013449 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 208964013450 23S rRNA interface [nucleotide binding]; other site 208964013451 putative translocon interaction site; other site 208964013452 signal recognition particle (SRP54) interaction site; other site 208964013453 L23 interface [polypeptide binding]; other site 208964013454 trigger factor interaction site; other site 208964013455 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 208964013456 23S rRNA interface [nucleotide binding]; other site 208964013457 5S rRNA interface [nucleotide binding]; other site 208964013458 putative antibiotic binding site [chemical binding]; other site 208964013459 L25 interface [polypeptide binding]; other site 208964013460 L27 interface [polypeptide binding]; other site 208964013461 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 208964013462 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 208964013463 G-X-X-G motif; other site 208964013464 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 208964013465 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 208964013466 protein-rRNA interface [nucleotide binding]; other site 208964013467 putative translocon binding site; other site 208964013468 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 208964013469 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 208964013470 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 208964013471 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 208964013472 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 208964013473 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 208964013474 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 208964013475 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 208964013476 elongation factor Tu; Reviewed; Region: PRK00049 208964013477 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 208964013478 G1 box; other site 208964013479 GEF interaction site [polypeptide binding]; other site 208964013480 GTP/Mg2+ binding site [chemical binding]; other site 208964013481 Switch I region; other site 208964013482 G2 box; other site 208964013483 G3 box; other site 208964013484 Switch II region; other site 208964013485 G4 box; other site 208964013486 G5 box; other site 208964013487 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 208964013488 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 208964013489 Antibiotic Binding Site [chemical binding]; other site 208964013490 elongation factor G; Reviewed; Region: PRK00007 208964013491 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 208964013492 G1 box; other site 208964013493 putative GEF interaction site [polypeptide binding]; other site 208964013494 GTP/Mg2+ binding site [chemical binding]; other site 208964013495 Switch I region; other site 208964013496 G2 box; other site 208964013497 G3 box; other site 208964013498 Switch II region; other site 208964013499 G4 box; other site 208964013500 G5 box; other site 208964013501 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 208964013502 Elongation Factor G, domain II; Region: EFG_II; pfam14492 208964013503 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 208964013504 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 208964013505 30S ribosomal protein S7; Validated; Region: PRK05302 208964013506 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 208964013507 S17 interaction site [polypeptide binding]; other site 208964013508 S8 interaction site; other site 208964013509 16S rRNA interaction site [nucleotide binding]; other site 208964013510 streptomycin interaction site [chemical binding]; other site 208964013511 23S rRNA interaction site [nucleotide binding]; other site 208964013512 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 208964013513 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 208964013514 beta and beta' interface [polypeptide binding]; other site 208964013515 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 208964013516 beta' and sigma factor interface [polypeptide binding]; other site 208964013517 Zn-binding [ion binding]; other site 208964013518 active site region [active] 208964013519 catalytic site [active] 208964013520 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 208964013521 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 208964013522 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 208964013523 G-loop; other site 208964013524 DNA binding site [nucleotide binding] 208964013525 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 208964013526 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 208964013527 RPB12 interaction site [polypeptide binding]; other site 208964013528 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 208964013529 RPB1 interaction site [polypeptide binding]; other site 208964013530 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 208964013531 RPB10 interaction site [polypeptide binding]; other site 208964013532 RPB11 interaction site [polypeptide binding]; other site 208964013533 RPB3 interaction site [polypeptide binding]; other site 208964013534 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 208964013535 core dimer interface [polypeptide binding]; other site 208964013536 peripheral dimer interface [polypeptide binding]; other site 208964013537 L10 interface [polypeptide binding]; other site 208964013538 L11 interface [polypeptide binding]; other site 208964013539 putative EF-Tu interaction site [polypeptide binding]; other site 208964013540 putative EF-G interaction site [polypeptide binding]; other site 208964013541 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 208964013542 23S rRNA interface [nucleotide binding]; other site 208964013543 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 208964013544 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 208964013545 mRNA/rRNA interface [nucleotide binding]; other site 208964013546 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 208964013547 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 208964013548 23S rRNA interface [nucleotide binding]; other site 208964013549 L7/L12 interface [polypeptide binding]; other site 208964013550 putative thiostrepton binding site; other site 208964013551 L25 interface [polypeptide binding]; other site 208964013552 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 208964013553 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 208964013554 putative homodimer interface [polypeptide binding]; other site 208964013555 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 208964013556 heterodimer interface [polypeptide binding]; other site 208964013557 homodimer interface [polypeptide binding]; other site 208964013558 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 208964013559 elongation factor Tu; Reviewed; Region: PRK00049 208964013560 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 208964013561 G1 box; other site 208964013562 GEF interaction site [polypeptide binding]; other site 208964013563 GTP/Mg2+ binding site [chemical binding]; other site 208964013564 Switch I region; other site 208964013565 G2 box; other site 208964013566 G3 box; other site 208964013567 Switch II region; other site 208964013568 G4 box; other site 208964013569 G5 box; other site 208964013570 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 208964013571 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 208964013572 Antibiotic Binding Site [chemical binding]; other site 208964013573 Sporulation related domain; Region: SPOR; pfam05036 208964013574 Sporulation related domain; Region: SPOR; pfam05036 208964013575 pantothenate kinase; Reviewed; Region: PRK13322 208964013576 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 208964013577 Biotin operon repressor [Transcription]; Region: BirA; COG1654 208964013578 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 208964013579 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 208964013580 exonuclease subunit SbcD; Provisional; Region: PRK10966 208964013581 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 208964013582 active site 208964013583 metal binding site [ion binding]; metal-binding site 208964013584 DNA binding site [nucleotide binding] 208964013585 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 208964013586 exonuclease subunit SbcC; Provisional; Region: PRK10246 208964013587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964013588 Walker A/P-loop; other site 208964013589 ATP binding site [chemical binding]; other site 208964013590 Q-loop/lid; other site 208964013591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964013592 ABC transporter signature motif; other site 208964013593 Walker B; other site 208964013594 D-loop; other site 208964013595 H-loop/switch region; other site 208964013596 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 208964013597 AAA domain; Region: AAA_30; pfam13604 208964013598 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 208964013599 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 208964013600 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 208964013601 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 208964013602 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 208964013603 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 208964013604 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 208964013605 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964013606 EamA-like transporter family; Region: EamA; pfam00892 208964013607 EamA-like transporter family; Region: EamA; pfam00892 208964013608 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964013609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964013610 Helix-turn-helix domain; Region: HTH_18; pfam12833 208964013611 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 208964013612 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 208964013613 Chromate transporter; Region: Chromate_transp; pfam02417 208964013614 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964013615 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964013616 dimer interface [polypeptide binding]; other site 208964013617 putative CheW interface [polypeptide binding]; other site 208964013618 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 208964013619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964013620 PAS fold; Region: PAS_3; pfam08447 208964013621 putative active site [active] 208964013622 heme pocket [chemical binding]; other site 208964013623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964013624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964013625 putative active site [active] 208964013626 heme pocket [chemical binding]; other site 208964013627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964013628 dimer interface [polypeptide binding]; other site 208964013629 phosphorylation site [posttranslational modification] 208964013630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964013631 ATP binding site [chemical binding]; other site 208964013632 Mg2+ binding site [ion binding]; other site 208964013633 G-X-G motif; other site 208964013634 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 208964013635 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 208964013636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964013637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964013638 active site 208964013639 phosphorylation site [posttranslational modification] 208964013640 intermolecular recognition site; other site 208964013641 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 208964013642 dimerization interface [polypeptide binding]; other site 208964013643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964013644 DNA binding residues [nucleotide binding] 208964013645 dimerization interface [polypeptide binding]; other site 208964013646 Predicted membrane protein [Function unknown]; Region: COG4655 208964013647 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 208964013648 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 208964013649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964013650 binding surface 208964013651 TPR motif; other site 208964013652 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 208964013653 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 208964013654 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 208964013655 ATP binding site [chemical binding]; other site 208964013656 Walker A motif; other site 208964013657 hexamer interface [polypeptide binding]; other site 208964013658 Walker B motif; other site 208964013659 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 208964013660 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 208964013661 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 208964013662 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 208964013663 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 208964013664 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 208964013665 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 208964013666 Cache domain; Region: Cache_1; pfam02743 208964013667 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964013668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964013669 dimerization interface [polypeptide binding]; other site 208964013670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964013671 dimer interface [polypeptide binding]; other site 208964013672 putative CheW interface [polypeptide binding]; other site 208964013673 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 208964013674 Domain of unknown function DUF87; Region: DUF87; cl19135 208964013675 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 208964013676 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 208964013677 Cache domain; Region: Cache_1; pfam02743 208964013678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964013679 dimerization interface [polypeptide binding]; other site 208964013680 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964013681 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964013682 dimer interface [polypeptide binding]; other site 208964013683 putative CheW interface [polypeptide binding]; other site 208964013684 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 208964013685 Cache domain; Region: Cache_1; pfam02743 208964013686 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964013687 dimerization interface [polypeptide binding]; other site 208964013688 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208964013689 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964013690 dimer interface [polypeptide binding]; other site 208964013691 putative CheW interface [polypeptide binding]; other site 208964013692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964013693 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 208964013694 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 208964013695 putative active site [active] 208964013696 putative Zn binding site [ion binding]; other site 208964013697 Predicted integral membrane protein [Function unknown]; Region: COG0392 208964013698 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 208964013699 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 208964013700 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 208964013701 putative active site [active] 208964013702 putative substrate binding site [chemical binding]; other site 208964013703 putative cosubstrate binding site; other site 208964013704 catalytic site [active] 208964013705 exonuclease I; Provisional; Region: sbcB; PRK11779 208964013706 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 208964013707 active site 208964013708 catalytic site [active] 208964013709 substrate binding site [chemical binding]; other site 208964013710 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 208964013711 Protein of unknown function (DUF975); Region: DUF975; cl10504 208964013712 RDD family; Region: RDD; pfam06271 208964013713 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 208964013714 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 208964013715 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 208964013716 MoxR-like ATPases [General function prediction only]; Region: COG0714 208964013717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964013718 Walker A motif; other site 208964013719 ATP binding site [chemical binding]; other site 208964013720 Walker B motif; other site 208964013721 arginine finger; other site 208964013722 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 208964013723 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 208964013724 metal ion-dependent adhesion site (MIDAS); other site 208964013725 PilZ domain; Region: PilZ; pfam07238 208964013726 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 208964013727 tol-pal system protein YbgF; Provisional; Region: PRK10803 208964013728 universal stress protein UspE; Provisional; Region: PRK11175 208964013729 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964013730 Ligand Binding Site [chemical binding]; other site 208964013731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964013732 Ligand Binding Site [chemical binding]; other site 208964013733 pyruvate kinase; Provisional; Region: PRK05826 208964013734 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 208964013735 domain interfaces; other site 208964013736 active site 208964013737 enoyl-CoA hydratase; Provisional; Region: PRK06688 208964013738 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964013739 substrate binding site [chemical binding]; other site 208964013740 oxyanion hole (OAH) forming residues; other site 208964013741 trimer interface [polypeptide binding]; other site 208964013742 hypothetical protein; Provisional; Region: PRK05713 208964013743 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964013744 catalytic loop [active] 208964013745 iron binding site [ion binding]; other site 208964013746 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 208964013747 FAD binding pocket [chemical binding]; other site 208964013748 conserved FAD binding motif [chemical binding]; other site 208964013749 phosphate binding motif [ion binding]; other site 208964013750 beta-alpha-beta structure motif; other site 208964013751 NAD binding pocket [chemical binding]; other site 208964013752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964013753 metal binding site [ion binding]; metal-binding site 208964013754 active site 208964013755 I-site; other site 208964013756 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 208964013757 Fumarase C-terminus; Region: Fumerase_C; pfam05683 208964013758 manganese transport protein MntH; Reviewed; Region: PRK00701 208964013759 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 208964013760 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 208964013761 intracellular protease, PfpI family; Region: PfpI; TIGR01382 208964013762 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 208964013763 conserved cys residue [active] 208964013764 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 208964013765 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 208964013766 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 208964013767 PLD-like domain; Region: PLDc_2; pfam13091 208964013768 putative active site [active] 208964013769 catalytic site [active] 208964013770 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 208964013771 PLD-like domain; Region: PLDc_2; pfam13091 208964013772 putative active site [active] 208964013773 catalytic site [active] 208964013774 YceI-like domain; Region: YceI; pfam04264 208964013775 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208964013776 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 208964013777 amidase; Provisional; Region: PRK07486 208964013778 citrate-proton symporter; Provisional; Region: PRK15075 208964013779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964013780 putative substrate translocation pore; other site 208964013781 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 208964013782 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 208964013783 metal binding site [ion binding]; metal-binding site 208964013784 putative dimer interface [polypeptide binding]; other site 208964013785 YceI-like domain; Region: YceI; pfam04264 208964013786 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 208964013787 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 208964013788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208964013789 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964013790 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964013791 active site 208964013792 Putative hemolysin [General function prediction only]; Region: COG3176 208964013793 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 208964013794 putative acyl-acceptor binding pocket; other site 208964013795 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964013796 Ligand Binding Site [chemical binding]; other site 208964013797 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964013798 Ligand Binding Site [chemical binding]; other site 208964013799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3124 208964013800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964013801 dimerization interface [polypeptide binding]; other site 208964013802 putative DNA binding site [nucleotide binding]; other site 208964013803 putative Zn2+ binding site [ion binding]; other site 208964013804 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964013805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964013806 putative substrate translocation pore; other site 208964013807 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 208964013808 FMN binding site [chemical binding]; other site 208964013809 active site 208964013810 substrate binding site [chemical binding]; other site 208964013811 catalytic residue [active] 208964013812 FeoC like transcriptional regulator; Region: FeoC; cl17677 208964013813 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 208964013814 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 208964013815 G1 box; other site 208964013816 GTP/Mg2+ binding site [chemical binding]; other site 208964013817 Switch I region; other site 208964013818 G2 box; other site 208964013819 G3 box; other site 208964013820 Switch II region; other site 208964013821 G4 box; other site 208964013822 G5 box; other site 208964013823 Nucleoside recognition; Region: Gate; pfam07670 208964013824 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 208964013825 Nucleoside recognition; Region: Gate; pfam07670 208964013826 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 208964013827 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208964013828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964013829 NAD(P) binding site [chemical binding]; other site 208964013830 active site 208964013831 Uncharacterized conserved protein [Function unknown]; Region: COG3268 208964013832 NAD(P) binding site [chemical binding]; other site 208964013833 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 208964013834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964013835 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964013836 dimerization interface [polypeptide binding]; other site 208964013837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 208964013838 ACT domain; Region: ACT_3; pfam10000 208964013839 ACT domain; Region: ACT_7; pfam13840 208964013840 Lysine efflux permease [General function prediction only]; Region: COG1279 208964013841 superoxide dismutase; Provisional; Region: PRK10543 208964013842 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 208964013843 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 208964013844 biofilm formation regulator HmsP; Provisional; Region: PRK11829 208964013845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964013846 metal binding site [ion binding]; metal-binding site 208964013847 active site 208964013848 I-site; other site 208964013849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964013850 E3 Ubiquitin ligase; Region: GIDE; pfam12483 208964013851 LemA family; Region: LemA; pfam04011 208964013852 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 208964013853 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 208964013854 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 208964013855 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 208964013856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 208964013857 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964013858 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964013859 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964013860 multidrug efflux protein; Reviewed; Region: PRK09579 208964013861 MMPL family; Region: MMPL; cl14618 208964013862 MMPL family; Region: MMPL; cl14618 208964013863 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 208964013864 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 208964013865 active site 208964013866 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 208964013867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964013868 S-adenosylmethionine binding site [chemical binding]; other site 208964013869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964013870 HAMP domain; Region: HAMP; pfam00672 208964013871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964013872 dimer interface [polypeptide binding]; other site 208964013873 phosphorylation site [posttranslational modification] 208964013874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964013875 ATP binding site [chemical binding]; other site 208964013876 Mg2+ binding site [ion binding]; other site 208964013877 G-X-G motif; other site 208964013878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964013879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964013880 active site 208964013881 phosphorylation site [posttranslational modification] 208964013882 intermolecular recognition site; other site 208964013883 dimerization interface [polypeptide binding]; other site 208964013884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964013885 DNA binding site [nucleotide binding] 208964013886 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 208964013887 active site 208964013888 chromosome condensation membrane protein; Provisional; Region: PRK14196 208964013889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4318 208964013890 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 208964013891 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 208964013892 ring oligomerisation interface [polypeptide binding]; other site 208964013893 ATP/Mg binding site [chemical binding]; other site 208964013894 stacking interactions; other site 208964013895 hinge regions; other site 208964013896 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 208964013897 oligomerisation interface [polypeptide binding]; other site 208964013898 mobile loop; other site 208964013899 roof hairpin; other site 208964013900 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 208964013901 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 208964013902 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 208964013903 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 208964013904 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 208964013905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964013906 NAD(P) binding site [chemical binding]; other site 208964013907 active site 208964013908 Protein of unknown function, DUF481; Region: DUF481; pfam04338 208964013909 Protein of unknown function, DUF481; Region: DUF481; pfam04338 208964013910 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 208964013911 DNA binding site [nucleotide binding] 208964013912 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 208964013913 active site 208964013914 AmpG-like permease; Region: 2A0125; TIGR00901 208964013915 mechanosensitive channel MscS; Provisional; Region: PRK10334 208964013916 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208964013917 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 208964013918 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 208964013919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964013920 active site 208964013921 phosphorylation site [posttranslational modification] 208964013922 intermolecular recognition site; other site 208964013923 dimerization interface [polypeptide binding]; other site 208964013924 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 208964013925 nucleotidyl binding site; other site 208964013926 metal binding site [ion binding]; metal-binding site 208964013927 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 208964013928 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 208964013929 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 208964013930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964013931 dimerization interface [polypeptide binding]; other site 208964013932 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 208964013933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964013934 putative active site [active] 208964013935 heme pocket [chemical binding]; other site 208964013936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964013937 dimer interface [polypeptide binding]; other site 208964013938 phosphorylation site [posttranslational modification] 208964013939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964013940 ATP binding site [chemical binding]; other site 208964013941 Mg2+ binding site [ion binding]; other site 208964013942 G-X-G motif; other site 208964013943 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 208964013944 hypothetical protein; Provisional; Region: PRK08999 208964013945 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 208964013946 active site 208964013947 8-oxo-dGMP binding site [chemical binding]; other site 208964013948 nudix motif; other site 208964013949 metal binding site [ion binding]; metal-binding site 208964013950 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 208964013951 thiamine phosphate binding site [chemical binding]; other site 208964013952 active site 208964013953 pyrophosphate binding site [ion binding]; other site 208964013954 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 208964013955 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 208964013956 putative C-terminal domain interface [polypeptide binding]; other site 208964013957 putative GSH binding site (G-site) [chemical binding]; other site 208964013958 putative dimer interface [polypeptide binding]; other site 208964013959 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 208964013960 putative N-terminal domain interface [polypeptide binding]; other site 208964013961 putative dimer interface [polypeptide binding]; other site 208964013962 putative substrate binding pocket (H-site) [chemical binding]; other site 208964013963 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 208964013964 heterotetramer interface [polypeptide binding]; other site 208964013965 active site pocket [active] 208964013966 cleavage site 208964013967 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 208964013968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 208964013969 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 208964013970 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964013971 nucleotide binding region [chemical binding]; other site 208964013972 ATP-binding site [chemical binding]; other site 208964013973 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 208964013974 SEC-C motif; Region: SEC-C; pfam02810 208964013975 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208964013976 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964013977 Protein of unknown function (DUF721); Region: DUF721; cl02324 208964013978 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 208964013979 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 208964013980 cell division protein FtsZ; Validated; Region: PRK09330 208964013981 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 208964013982 nucleotide binding site [chemical binding]; other site 208964013983 SulA interaction site; other site 208964013984 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 208964013985 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 208964013986 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 208964013987 nucleotide binding site [chemical binding]; other site 208964013988 Cell division protein FtsA; Region: FtsA; pfam14450 208964013989 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 208964013990 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 208964013991 Cell division protein FtsQ; Region: FtsQ; pfam03799 208964013992 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 208964013993 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 208964013994 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964013995 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 208964013996 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208964013997 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208964013998 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208964013999 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 208964014000 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 208964014001 active site 208964014002 homodimer interface [polypeptide binding]; other site 208964014003 cell division protein FtsW; Region: ftsW; TIGR02614 208964014004 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 208964014005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964014006 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208964014007 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208964014008 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 208964014009 Mg++ binding site [ion binding]; other site 208964014010 putative catalytic motif [active] 208964014011 putative substrate binding site [chemical binding]; other site 208964014012 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208964014013 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 208964014014 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208964014015 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208964014016 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 208964014017 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208964014018 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208964014019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208964014020 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 208964014021 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 208964014022 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 208964014023 Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116 208964014024 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 208964014025 cell division protein MraZ; Reviewed; Region: PRK00326 208964014026 MraZ protein; Region: MraZ; pfam02381 208964014027 MraZ protein; Region: MraZ; pfam02381 208964014028 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 208964014029 putative SAM binding site [chemical binding]; other site 208964014030 putative homodimer interface [polypeptide binding]; other site 208964014031 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 208964014032 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 208964014033 putative ligand binding site [chemical binding]; other site 208964014034 hypothetical protein; Reviewed; Region: PRK12497 208964014035 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 208964014036 dimer interface [polypeptide binding]; other site 208964014037 active site 208964014038 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 208964014039 BON domain; Region: BON; pfam04972 208964014040 BON domain; Region: BON; pfam04972 208964014041 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 208964014042 stringent starvation protein A; Provisional; Region: sspA; PRK09481 208964014043 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 208964014044 C-terminal domain interface [polypeptide binding]; other site 208964014045 putative GSH binding site (G-site) [chemical binding]; other site 208964014046 dimer interface [polypeptide binding]; other site 208964014047 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 208964014048 dimer interface [polypeptide binding]; other site 208964014049 N-terminal domain interface [polypeptide binding]; other site 208964014050 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 208964014051 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 208964014052 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 208964014053 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 208964014054 Qi binding site; other site 208964014055 intrachain domain interface; other site 208964014056 interchain domain interface [polypeptide binding]; other site 208964014057 heme bH binding site [chemical binding]; other site 208964014058 heme bL binding site [chemical binding]; other site 208964014059 Qo binding site; other site 208964014060 interchain domain interface [polypeptide binding]; other site 208964014061 intrachain domain interface; other site 208964014062 Qi binding site; other site 208964014063 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 208964014064 Qo binding site; other site 208964014065 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 208964014066 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 208964014067 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 208964014068 [2Fe-2S] cluster binding site [ion binding]; other site 208964014069 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 208964014070 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 208964014071 23S rRNA interface [nucleotide binding]; other site 208964014072 L3 interface [polypeptide binding]; other site 208964014073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208964014074 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 208964014075 active site 208964014076 catalytic tetrad [active] 208964014077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964014078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964014079 active site 208964014080 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 208964014081 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 208964014082 conserved cys residue [active] 208964014083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964014084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964014085 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 208964014086 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 208964014087 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 208964014088 active site 208964014089 HIGH motif; other site 208964014090 dimer interface [polypeptide binding]; other site 208964014091 KMSKS motif; other site 208964014092 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 208964014093 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964014094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 208964014095 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 208964014096 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 208964014097 CysD dimerization site [polypeptide binding]; other site 208964014098 G1 box; other site 208964014099 putative GEF interaction site [polypeptide binding]; other site 208964014100 GTP/Mg2+ binding site [chemical binding]; other site 208964014101 Switch I region; other site 208964014102 G2 box; other site 208964014103 G3 box; other site 208964014104 Switch II region; other site 208964014105 G4 box; other site 208964014106 G5 box; other site 208964014107 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 208964014108 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 208964014109 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 208964014110 ligand-binding site [chemical binding]; other site 208964014111 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 208964014112 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 208964014113 Active Sites [active] 208964014114 murein hydrolase B; Provisional; Region: PRK10760 208964014115 Transglycosylase SLT domain; Region: SLT_2; cl19381 208964014116 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 208964014117 N-acetyl-D-glucosamine binding site [chemical binding]; other site 208964014118 catalytic residue [active] 208964014119 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 208964014120 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 208964014121 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 208964014122 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 208964014123 protein binding site [polypeptide binding]; other site 208964014124 histidinol-phosphate aminotransferase; Provisional; Region: PRK05387 208964014125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964014126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964014127 homodimer interface [polypeptide binding]; other site 208964014128 catalytic residue [active] 208964014129 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 208964014130 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 208964014131 NAD binding site [chemical binding]; other site 208964014132 dimerization interface [polypeptide binding]; other site 208964014133 product binding site; other site 208964014134 substrate binding site [chemical binding]; other site 208964014135 zinc binding site [ion binding]; other site 208964014136 catalytic residues [active] 208964014137 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 208964014138 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 208964014139 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 208964014140 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 208964014141 hinge; other site 208964014142 active site 208964014143 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 208964014144 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 208964014145 anti sigma factor interaction site; other site 208964014146 regulatory phosphorylation site [posttranslational modification]; other site 208964014147 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 208964014148 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 208964014149 mce related protein; Region: MCE; pfam02470 208964014150 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 208964014151 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 208964014152 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 208964014153 Walker A/P-loop; other site 208964014154 ATP binding site [chemical binding]; other site 208964014155 Q-loop/lid; other site 208964014156 ABC transporter signature motif; other site 208964014157 Walker B; other site 208964014158 D-loop; other site 208964014159 H-loop/switch region; other site 208964014160 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 208964014161 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 208964014162 putative active site [active] 208964014163 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 208964014164 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 208964014165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964014166 active site 208964014167 motif I; other site 208964014168 motif II; other site 208964014169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 208964014170 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 208964014171 OstA-like protein; Region: OstA; pfam03968 208964014172 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 208964014173 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 208964014174 Walker A/P-loop; other site 208964014175 ATP binding site [chemical binding]; other site 208964014176 Q-loop/lid; other site 208964014177 ABC transporter signature motif; other site 208964014178 Walker B; other site 208964014179 D-loop; other site 208964014180 H-loop/switch region; other site 208964014181 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 208964014182 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 208964014183 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 208964014184 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 208964014185 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 208964014186 30S subunit binding site; other site 208964014187 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208964014188 active site 208964014189 phosphorylation site [posttranslational modification] 208964014190 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 208964014191 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 208964014192 dimerization domain swap beta strand [polypeptide binding]; other site 208964014193 regulatory protein interface [polypeptide binding]; other site 208964014194 active site 208964014195 regulatory phosphorylation site [posttranslational modification]; other site 208964014196 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 208964014197 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 208964014198 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 208964014199 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 208964014200 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 208964014201 fumarate hydratase; Reviewed; Region: fumC; PRK00485 208964014202 Class II fumarases; Region: Fumarase_classII; cd01362 208964014203 active site 208964014204 tetramer interface [polypeptide binding]; other site 208964014205 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 208964014206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 208964014207 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 208964014208 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 208964014209 putative active site [active] 208964014210 catalytic triad [active] 208964014211 dimer interface [polypeptide binding]; other site 208964014212 Predicted membrane protein [Function unknown]; Region: COG3164 208964014213 Protein of unknown function; Region: DUF3971; pfam13116 208964014214 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 208964014215 ribonuclease G; Provisional; Region: PRK11712 208964014216 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 208964014217 homodimer interface [polypeptide binding]; other site 208964014218 oligonucleotide binding site [chemical binding]; other site 208964014219 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 208964014220 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 208964014221 active site 208964014222 dimer interface [polypeptide binding]; other site 208964014223 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 208964014224 rod shape-determining protein MreC; Provisional; Region: PRK13922 208964014225 rod shape-determining protein MreB; Provisional; Region: PRK13927 208964014226 MreB and similar proteins; Region: MreB_like; cd10225 208964014227 nucleotide binding site [chemical binding]; other site 208964014228 Mg binding site [ion binding]; other site 208964014229 putative protofilament interaction site [polypeptide binding]; other site 208964014230 RodZ interaction site [polypeptide binding]; other site 208964014231 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 208964014232 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 208964014233 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 208964014234 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 208964014235 GatB domain; Region: GatB_Yqey; smart00845 208964014236 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 208964014237 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 208964014238 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 208964014239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 208964014240 Predicted secreted protein [Function unknown]; Region: COG5445 208964014241 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 208964014242 Predicted secreted protein [Function unknown]; Region: COG5445 208964014243 Stage II sporulation protein; Region: SpoIID; pfam08486 208964014244 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 208964014245 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 208964014246 MG2 domain; Region: A2M_N; pfam01835 208964014247 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 208964014248 Alpha-2-macroglobulin family; Region: A2M; pfam00207 208964014249 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 208964014250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 208964014251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 208964014252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 208964014253 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 208964014254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964014255 active site 208964014256 phosphorylation site [posttranslational modification] 208964014257 intermolecular recognition site; other site 208964014258 dimerization interface [polypeptide binding]; other site 208964014259 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964014260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964014261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964014262 phosphorylation site [posttranslational modification] 208964014263 dimer interface [polypeptide binding]; other site 208964014264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964014265 ATP binding site [chemical binding]; other site 208964014266 G-X-G motif; other site 208964014267 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 208964014268 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 208964014269 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 208964014270 peptide binding site [polypeptide binding]; other site 208964014271 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 208964014272 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 208964014273 peptide binding site [polypeptide binding]; other site 208964014274 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 208964014275 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 208964014276 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 208964014277 active site 208964014278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964014279 non-specific DNA binding site [nucleotide binding]; other site 208964014280 salt bridge; other site 208964014281 sequence-specific DNA binding site [nucleotide binding]; other site 208964014282 Cupin domain; Region: Cupin_2; pfam07883 208964014283 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 208964014284 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 208964014285 peptide binding site [polypeptide binding]; other site 208964014286 outer membrane porin, OprD family; Region: OprD; pfam03573 208964014287 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 208964014288 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 208964014289 peptide binding site [polypeptide binding]; other site 208964014290 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 208964014291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964014292 dimer interface [polypeptide binding]; other site 208964014293 conserved gate region; other site 208964014294 putative PBP binding loops; other site 208964014295 ABC-ATPase subunit interface; other site 208964014296 dipeptide transporter; Provisional; Region: PRK10913 208964014297 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 208964014298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964014299 dimer interface [polypeptide binding]; other site 208964014300 conserved gate region; other site 208964014301 putative PBP binding loops; other site 208964014302 ABC-ATPase subunit interface; other site 208964014303 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 208964014304 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208964014305 Walker A/P-loop; other site 208964014306 ATP binding site [chemical binding]; other site 208964014307 Q-loop/lid; other site 208964014308 ABC transporter signature motif; other site 208964014309 Walker B; other site 208964014310 D-loop; other site 208964014311 H-loop/switch region; other site 208964014312 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208964014313 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 208964014314 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208964014315 Walker A/P-loop; other site 208964014316 ATP binding site [chemical binding]; other site 208964014317 Q-loop/lid; other site 208964014318 ABC transporter signature motif; other site 208964014319 Walker B; other site 208964014320 D-loop; other site 208964014321 H-loop/switch region; other site 208964014322 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208964014323 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 208964014324 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964014325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964014326 putative DNA binding site [nucleotide binding]; other site 208964014327 putative Zn2+ binding site [ion binding]; other site 208964014328 AsnC family; Region: AsnC_trans_reg; pfam01037 208964014329 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 208964014330 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 208964014331 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 208964014332 putative active site [active] 208964014333 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 208964014334 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 208964014335 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 208964014336 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 208964014337 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 208964014338 Flavodoxin; Region: Flavodoxin_1; pfam00258 208964014339 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 208964014340 FAD binding pocket [chemical binding]; other site 208964014341 FAD binding motif [chemical binding]; other site 208964014342 catalytic residues [active] 208964014343 NAD binding pocket [chemical binding]; other site 208964014344 phosphate binding motif [ion binding]; other site 208964014345 beta-alpha-beta structure motif; other site 208964014346 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 208964014347 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964014348 N-terminal plug; other site 208964014349 ligand-binding site [chemical binding]; other site 208964014350 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 208964014351 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 208964014352 Sel1-like repeats; Region: SEL1; smart00671 208964014353 Sel1-like repeats; Region: SEL1; smart00671 208964014354 Sel1-like repeats; Region: SEL1; smart00671 208964014355 hypothetical protein; Provisional; Region: PRK10649 208964014356 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 208964014357 Sulfatase; Region: Sulfatase; pfam00884 208964014358 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 208964014359 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 208964014360 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 208964014361 dimer interface [polypeptide binding]; other site 208964014362 active site 208964014363 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208964014364 catalytic residues [active] 208964014365 substrate binding site [chemical binding]; other site 208964014366 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964014367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964014368 dimerization interface [polypeptide binding]; other site 208964014369 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 208964014370 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964014371 dimer interface [polypeptide binding]; other site 208964014372 putative CheW interface [polypeptide binding]; other site 208964014373 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; COG3725 208964014374 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 208964014375 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 208964014376 amidase catalytic site [active] 208964014377 Zn binding residues [ion binding]; other site 208964014378 substrate binding site [chemical binding]; other site 208964014379 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 208964014380 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 208964014381 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 208964014382 dimerization interface [polypeptide binding]; other site 208964014383 active site 208964014384 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 208964014385 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 208964014386 Pilin (bacterial filament); Region: Pilin; pfam00114 208964014387 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 208964014388 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 208964014389 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 208964014390 Walker A motif; other site 208964014391 ATP binding site [chemical binding]; other site 208964014392 Walker B motif; other site 208964014393 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 208964014394 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 208964014395 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 208964014396 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 208964014397 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 208964014398 CoA-binding site [chemical binding]; other site 208964014399 ATP-binding [chemical binding]; other site 208964014400 DNA gyrase inhibitor; Reviewed; Region: PRK00418 208964014401 Predicted membrane protein [Function unknown]; Region: COG3235 208964014402 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 208964014403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964014404 Coenzyme A binding pocket [chemical binding]; other site 208964014405 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 208964014406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 208964014407 MOSC domain; Region: MOSC; pfam03473 208964014408 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 208964014409 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 208964014410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964014411 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 208964014412 Walker A motif; other site 208964014413 ATP binding site [chemical binding]; other site 208964014414 Walker B motif; other site 208964014415 arginine finger; other site 208964014416 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 208964014417 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 208964014418 Surface antigen; Region: Bac_surface_Ag; pfam01103 208964014419 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 208964014420 haemagglutination activity domain; Region: Haemagg_act; pfam05860 208964014421 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 208964014422 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 208964014423 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 208964014424 Clp amino terminal domain; Region: Clp_N; pfam02861 208964014425 Clp amino terminal domain; Region: Clp_N; pfam02861 208964014426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964014427 Walker A motif; other site 208964014428 ATP binding site [chemical binding]; other site 208964014429 Walker B motif; other site 208964014430 arginine finger; other site 208964014431 Protein of unknown function (DUF342); Region: DUF342; cl19219 208964014432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964014433 Walker A motif; other site 208964014434 ATP binding site [chemical binding]; other site 208964014435 Walker B motif; other site 208964014436 arginine finger; other site 208964014437 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 208964014438 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 208964014439 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 208964014440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208964014441 RNA binding surface [nucleotide binding]; other site 208964014442 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 208964014443 active site 208964014444 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 208964014445 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 208964014446 PAS domain; Region: PAS; smart00091 208964014447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964014448 dimer interface [polypeptide binding]; other site 208964014449 phosphorylation site [posttranslational modification] 208964014450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964014451 ATP binding site [chemical binding]; other site 208964014452 Mg2+ binding site [ion binding]; other site 208964014453 G-X-G motif; other site 208964014454 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964014455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964014456 active site 208964014457 phosphorylation site [posttranslational modification] 208964014458 intermolecular recognition site; other site 208964014459 dimerization interface [polypeptide binding]; other site 208964014460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964014461 Walker A motif; other site 208964014462 ATP binding site [chemical binding]; other site 208964014463 Walker B motif; other site 208964014464 arginine finger; other site 208964014465 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964014466 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964014467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964014468 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 208964014469 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 208964014470 Type II transport protein GspH; Region: GspH; pfam12019 208964014471 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 208964014472 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 208964014473 Type II transport protein GspH; Region: GspH; pfam12019 208964014474 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 208964014475 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 208964014476 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 208964014477 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 208964014478 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 208964014479 PilX N-terminal; Region: PilX_N; pfam14341 208964014480 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 208964014481 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 208964014482 Type 4 fimbrial biogenesis protein PilY2; Region: Fimbrial_PilY2; pfam14481 208964014483 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 208964014484 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 208964014485 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 208964014486 Fe-S cluster binding site [ion binding]; other site 208964014487 substrate binding site [chemical binding]; other site 208964014488 catalytic site [active] 208964014489 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 208964014490 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 208964014491 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 208964014492 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 208964014493 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 208964014494 active site 208964014495 HIGH motif; other site 208964014496 KMSKS motif; other site 208964014497 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 208964014498 tRNA binding surface [nucleotide binding]; other site 208964014499 anticodon binding site; other site 208964014500 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 208964014501 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 208964014502 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 208964014503 active site 208964014504 Riboflavin kinase; Region: Flavokinase; smart00904 208964014505 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 208964014506 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 208964014507 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 208964014508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 208964014509 gamma-glutamyl kinase; Provisional; Region: PRK05429 208964014510 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 208964014511 nucleotide binding site [chemical binding]; other site 208964014512 homotetrameric interface [polypeptide binding]; other site 208964014513 putative phosphate binding site [ion binding]; other site 208964014514 putative allosteric binding site; other site 208964014515 PUA domain; Region: PUA; pfam01472 208964014516 GTPase CgtA; Reviewed; Region: obgE; PRK12298 208964014517 GTP1/OBG; Region: GTP1_OBG; pfam01018 208964014518 Obg GTPase; Region: Obg; cd01898 208964014519 G1 box; other site 208964014520 GTP/Mg2+ binding site [chemical binding]; other site 208964014521 Switch I region; other site 208964014522 G2 box; other site 208964014523 G3 box; other site 208964014524 Switch II region; other site 208964014525 G4 box; other site 208964014526 G5 box; other site 208964014527 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 208964014528 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 208964014529 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 208964014530 substrate binding pocket [chemical binding]; other site 208964014531 chain length determination region; other site 208964014532 substrate-Mg2+ binding site; other site 208964014533 catalytic residues [active] 208964014534 aspartate-rich region 1; other site 208964014535 active site lid residues [active] 208964014536 aspartate-rich region 2; other site 208964014537 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964014538 Cytochrome c; Region: Cytochrom_C; cl11414 208964014539 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964014540 Cytochrome c; Region: Cytochrom_C; pfam00034 208964014541 Cytochrome c [Energy production and conversion]; Region: COG3258 208964014542 Cytochrome c; Region: Cytochrom_C; pfam00034 208964014543 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 208964014544 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 208964014545 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 208964014546 hypothetical protein; Provisional; Region: PRK05208 208964014547 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 208964014548 AAA domain; Region: AAA_32; pfam13654 208964014549 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 208964014550 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 208964014551 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 208964014552 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 208964014553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 208964014554 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 208964014555 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 208964014556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964014557 Walker A motif; other site 208964014558 ATP binding site [chemical binding]; other site 208964014559 Walker B motif; other site 208964014560 arginine finger; other site 208964014561 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 208964014562 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u2; cd13438 208964014563 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 208964014564 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 208964014565 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 208964014566 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 208964014567 active site 208964014568 NTP binding site [chemical binding]; other site 208964014569 metal binding triad [ion binding]; metal-binding site 208964014570 antibiotic binding site [chemical binding]; other site 208964014571 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 208964014572 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 208964014573 putative active site [active] 208964014574 adenylation catalytic residue [active] 208964014575 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 208964014576 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 208964014577 glutamate dehydrogenase; Provisional; Region: PRK09414 208964014578 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 208964014579 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 208964014580 NAD(P) binding site [chemical binding]; other site 208964014581 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 208964014582 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 208964014583 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964014584 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964014585 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 208964014586 Outer membrane efflux protein; Region: OEP; pfam02321 208964014587 Outer membrane efflux protein; Region: OEP; pfam02321 208964014588 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208964014589 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 208964014590 FtsX-like permease family; Region: FtsX; pfam02687 208964014591 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208964014592 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208964014593 Walker A/P-loop; other site 208964014594 ATP binding site [chemical binding]; other site 208964014595 Q-loop/lid; other site 208964014596 ABC transporter signature motif; other site 208964014597 Walker B; other site 208964014598 D-loop; other site 208964014599 H-loop/switch region; other site 208964014600 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 208964014601 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964014602 ABC transporter; Region: ABC_tran_2; pfam12848 208964014603 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964014604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964014605 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 208964014606 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 208964014607 Outer membrane efflux protein; Region: OEP; pfam02321 208964014608 Outer membrane efflux protein; Region: OEP; pfam02321 208964014609 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 208964014610 MMPL family; Region: MMPL; cl14618 208964014611 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 208964014612 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964014613 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964014614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964014615 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 208964014616 PAS domain; Region: PAS_9; pfam13426 208964014617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964014618 PAS fold; Region: PAS_3; pfam08447 208964014619 putative active site [active] 208964014620 heme pocket [chemical binding]; other site 208964014621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964014622 PAS domain; Region: PAS_9; pfam13426 208964014623 putative active site [active] 208964014624 heme pocket [chemical binding]; other site 208964014625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964014626 PAS domain; Region: PAS_9; pfam13426 208964014627 putative active site [active] 208964014628 heme pocket [chemical binding]; other site 208964014629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964014630 metal binding site [ion binding]; metal-binding site 208964014631 active site 208964014632 I-site; other site 208964014633 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964014634 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 208964014635 dimer interface [polypeptide binding]; other site 208964014636 active site 208964014637 glycine-pyridoxal phosphate binding site [chemical binding]; other site 208964014638 folate binding site [chemical binding]; other site 208964014639 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 208964014640 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 208964014641 P-loop, Walker A motif; other site 208964014642 Base recognition motif; other site 208964014643 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 208964014644 Protein of unknown function (DUF466); Region: DUF466; pfam04328 208964014645 carbon starvation protein A; Provisional; Region: PRK15015 208964014646 Carbon starvation protein CstA; Region: CstA; pfam02554 208964014647 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 208964014648 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 208964014649 PilZ domain; Region: PilZ; pfam07238 208964014650 DNA repair protein RadA; Provisional; Region: PRK11823 208964014651 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 208964014652 Walker A motif/ATP binding site; other site 208964014653 ATP binding site [chemical binding]; other site 208964014654 Walker B motif; other site 208964014655 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 208964014656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 208964014657 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 208964014658 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 208964014659 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 208964014660 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 208964014661 tetramer interface [polypeptide binding]; other site 208964014662 heme binding pocket [chemical binding]; other site 208964014663 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 208964014664 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 208964014665 ferredoxin-NADP reductase; Provisional; Region: PRK10926 208964014666 FAD binding pocket [chemical binding]; other site 208964014667 FAD binding motif [chemical binding]; other site 208964014668 phosphate binding motif [ion binding]; other site 208964014669 beta-alpha-beta structure motif; other site 208964014670 NAD binding pocket [chemical binding]; other site 208964014671 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 208964014672 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 208964014673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964014674 S-adenosylmethionine binding site [chemical binding]; other site 208964014675 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 208964014676 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 208964014677 XdhC Rossmann domain; Region: XdhC_C; pfam13478 208964014678 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964014679 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964014680 Cytochrome c; Region: Cytochrom_C; pfam00034 208964014681 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 208964014682 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 208964014683 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 208964014684 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 208964014685 enterobactin exporter EntS; Provisional; Region: PRK10489 208964014686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964014687 putative substrate translocation pore; other site 208964014688 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 208964014689 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 208964014690 haemagglutination activity domain; Region: Haemagg_act; pfam05860 208964014691 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 208964014692 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 208964014693 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 208964014694 putative ligand binding site [chemical binding]; other site 208964014695 putative NAD binding site [chemical binding]; other site 208964014696 catalytic site [active] 208964014697 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 208964014698 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 208964014699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964014700 S-adenosylmethionine binding site [chemical binding]; other site 208964014701 lysine transporter; Provisional; Region: PRK10836 208964014702 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964014703 Predicted membrane protein [Function unknown]; Region: COG2119 208964014704 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 208964014705 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 208964014706 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 208964014707 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 208964014708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964014709 NAD(P) binding site [chemical binding]; other site 208964014710 active site 208964014711 Peptidase family M48; Region: Peptidase_M48; pfam01435 208964014712 Cache domain; Region: Cache_1; pfam02743 208964014713 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964014714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964014715 dimerization interface [polypeptide binding]; other site 208964014716 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964014717 dimer interface [polypeptide binding]; other site 208964014718 putative CheW interface [polypeptide binding]; other site 208964014719 Uncharacterized conserved protein [Function unknown]; Region: COG2135 208964014720 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 208964014721 MgtC family; Region: MgtC; pfam02308 208964014722 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 208964014723 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 208964014724 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 208964014725 putative acyl-acceptor binding pocket; other site 208964014726 Uncharacterized lipoprotein; Region: Lipoprotein_16; cl19472 208964014727 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 208964014728 Predicted dehydrogenase [General function prediction only]; Region: COG0579 208964014729 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 208964014730 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964014731 active site 208964014732 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964014733 active site 208964014734 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 208964014735 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964014736 Uncharacterized secreted protein [Function unknown]; Region: COG5430 208964014737 Uncharacterized secreted protein [Function unknown]; Region: COG5430 208964014738 Uncharacterized secreted protein [Function unknown]; Region: COG5430 208964014739 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 208964014740 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 208964014741 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 208964014742 PapC N-terminal domain; Region: PapC_N; pfam13954 208964014743 Outer membrane usher protein; Region: Usher; pfam00577 208964014744 PapC C-terminal domain; Region: PapC_C; pfam13953 208964014745 Spore Coat Protein U domain; Region: SCPU; pfam05229 208964014746 Uncharacterized secreted protein [Function unknown]; Region: COG5430 208964014747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964014748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964014749 putative substrate translocation pore; other site 208964014750 ferrochelatase; Reviewed; Region: hemH; PRK00035 208964014751 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 208964014752 C-terminal domain interface [polypeptide binding]; other site 208964014753 active site 208964014754 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 208964014755 active site 208964014756 N-terminal domain interface [polypeptide binding]; other site 208964014757 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 208964014758 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 208964014759 putative NAD(P) binding site [chemical binding]; other site 208964014760 putative active site [active] 208964014761 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 208964014762 Uncharacterized conserved protein [Function unknown]; Region: COG1683 208964014763 Uncharacterized conserved protein [Function unknown]; Region: COG3272 208964014764 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 208964014765 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 208964014766 DNA binding residues [nucleotide binding] 208964014767 B12 binding domain; Region: B12-binding_2; pfam02607 208964014768 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 208964014769 DNA photolyase; Region: DNA_photolyase; pfam00875 208964014770 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 208964014771 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 208964014772 glutamate racemase; Provisional; Region: PRK00865 208964014773 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 208964014774 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 208964014775 ATP binding site [chemical binding]; other site 208964014776 substrate interface [chemical binding]; other site 208964014777 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 208964014778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964014779 S-adenosylmethionine binding site [chemical binding]; other site 208964014780 peptide chain release factor 1; Validated; Region: prfA; PRK00591 208964014781 This domain is found in peptide chain release factors; Region: PCRF; smart00937 208964014782 RF-1 domain; Region: RF-1; pfam00472 208964014783 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 208964014784 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 208964014785 tRNA; other site 208964014786 putative tRNA binding site [nucleotide binding]; other site 208964014787 putative NADP binding site [chemical binding]; other site 208964014788 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 208964014789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964014790 binding surface 208964014791 Tetratricopeptide repeat; Region: TPR_16; pfam13432 208964014792 TPR motif; other site 208964014793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964014794 binding surface 208964014795 TPR motif; other site 208964014796 TPR repeat; Region: TPR_11; pfam13414 208964014797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964014798 binding surface 208964014799 TPR motif; other site 208964014800 Tetratricopeptide repeat; Region: TPR_19; pfam14559 208964014801 Outer membrane lipoprotein LolB; Region: LolB; cl19307 208964014802 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 208964014803 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 208964014804 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 208964014805 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 208964014806 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964014807 active site 208964014808 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 208964014809 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 208964014810 5S rRNA interface [nucleotide binding]; other site 208964014811 CTC domain interface [polypeptide binding]; other site 208964014812 L16 interface [polypeptide binding]; other site 208964014813 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 208964014814 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 208964014815 putative active site [active] 208964014816 catalytic residue [active] 208964014817 GTP-binding protein YchF; Reviewed; Region: PRK09601 208964014818 YchF GTPase; Region: YchF; cd01900 208964014819 G1 box; other site 208964014820 GTP/Mg2+ binding site [chemical binding]; other site 208964014821 Switch I region; other site 208964014822 G2 box; other site 208964014823 Switch II region; other site 208964014824 G3 box; other site 208964014825 G4 box; other site 208964014826 G5 box; other site 208964014827 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 208964014828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964014829 non-specific DNA binding site [nucleotide binding]; other site 208964014830 salt bridge; other site 208964014831 sequence-specific DNA binding site [nucleotide binding]; other site 208964014832 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 208964014833 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964014834 N-terminal plug; other site 208964014835 ligand-binding site [chemical binding]; other site 208964014836 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 208964014837 active site clefts [active] 208964014838 zinc binding site [ion binding]; other site 208964014839 dimer interface [polypeptide binding]; other site 208964014840 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 208964014841 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 208964014842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964014843 Coenzyme A binding pocket [chemical binding]; other site 208964014844 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 208964014845 Trypsin-like peptidase domain; Region: Trypsin_2; cl19303 208964014846 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 208964014847 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 208964014848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964014849 dimer interface [polypeptide binding]; other site 208964014850 conserved gate region; other site 208964014851 putative PBP binding loops; other site 208964014852 ABC-ATPase subunit interface; other site 208964014853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964014854 dimer interface [polypeptide binding]; other site 208964014855 conserved gate region; other site 208964014856 putative PBP binding loops; other site 208964014857 ABC-ATPase subunit interface; other site 208964014858 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 208964014859 mce related protein; Region: MCE; pfam02470 208964014860 mce related protein; Region: MCE; pfam02470 208964014861 mce related protein; Region: MCE; pfam02470 208964014862 mce related protein; Region: MCE; pfam02470 208964014863 mce related protein; Region: MCE; pfam02470 208964014864 mce related protein; Region: MCE; pfam02470 208964014865 Paraquat-inducible protein A; Region: PqiA; pfam04403 208964014866 Paraquat-inducible protein A; Region: PqiA; pfam04403 208964014867 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 208964014868 TMAO/DMSO reductase; Reviewed; Region: PRK05363 208964014869 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 208964014870 Moco binding site; other site 208964014871 metal coordination site [ion binding]; other site 208964014872 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 208964014873 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 208964014874 ketol-acid reductoisomerase; Provisional; Region: PRK05479 208964014875 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 208964014876 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 208964014877 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 208964014878 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 208964014879 putative valine binding site [chemical binding]; other site 208964014880 dimer interface [polypeptide binding]; other site 208964014881 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 208964014882 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 208964014883 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 208964014884 PYR/PP interface [polypeptide binding]; other site 208964014885 dimer interface [polypeptide binding]; other site 208964014886 TPP binding site [chemical binding]; other site 208964014887 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964014888 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 208964014889 TPP-binding site [chemical binding]; other site 208964014890 dimer interface [polypeptide binding]; other site 208964014891 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 208964014892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 208964014893 Transcription factor IIA, alpha/beta subunit; Region: TFIIA; pfam03153 208964014894 Tetratricopeptide repeat; Region: TPR_19; pfam14559 208964014895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964014896 TPR motif; other site 208964014897 binding surface 208964014898 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 208964014899 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 208964014900 Transglycosylase; Region: Transgly; pfam00912 208964014901 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 208964014902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 208964014903 Predicted kinase [General function prediction only]; Region: COG0645 208964014904 AAA domain; Region: AAA_33; pfam13671 208964014905 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 208964014906 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 208964014907 TfoX C-terminal domain; Region: TfoX_C; pfam04994 208964014908 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208964014909 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 208964014910 ligand binding site [chemical binding]; other site 208964014911 flexible hinge region; other site 208964014912 Uncharacterized iron-regulated protein [Function unknown]; Region: PhuW; COG3016 208964014913 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 208964014914 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 208964014915 Walker A/P-loop; other site 208964014916 ATP binding site [chemical binding]; other site 208964014917 Q-loop/lid; other site 208964014918 ABC transporter signature motif; other site 208964014919 Walker B; other site 208964014920 D-loop; other site 208964014921 H-loop/switch region; other site 208964014922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208964014923 ABC-ATPase subunit interface; other site 208964014924 dimer interface [polypeptide binding]; other site 208964014925 putative PBP binding regions; other site 208964014926 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 208964014927 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 208964014928 putative hemin binding site; other site 208964014929 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 208964014930 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 208964014931 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 208964014932 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 208964014933 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964014934 N-terminal plug; other site 208964014935 ligand-binding site [chemical binding]; other site 208964014936 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 208964014937 iron-sulfur cluster [ion binding]; other site 208964014938 [2Fe-2S] cluster binding site [ion binding]; other site 208964014939 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 208964014940 Predicted metal-binding protein [General function prediction only]; Region: COG3019 208964014941 aminotransferase; Validated; Region: PRK08175 208964014942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964014943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964014944 homodimer interface [polypeptide binding]; other site 208964014945 catalytic residue [active] 208964014946 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 208964014947 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 208964014948 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 208964014949 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 208964014950 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 208964014951 Sulfate transporter family; Region: Sulfate_transp; cl19250 208964014952 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 208964014953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964014954 S-adenosylmethionine binding site [chemical binding]; other site 208964014955 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 208964014956 hypothetical protein; Provisional; Region: PRK08960 208964014957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964014958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964014959 homodimer interface [polypeptide binding]; other site 208964014960 catalytic residue [active] 208964014961 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 208964014962 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 208964014963 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 208964014964 active site 208964014965 nucleotide binding site [chemical binding]; other site 208964014966 HIGH motif; other site 208964014967 KMSKS motif; other site 208964014968 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 208964014969 Na binding site [ion binding]; other site 208964014970 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 208964014971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964014972 putative active site [active] 208964014973 heme pocket [chemical binding]; other site 208964014974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964014975 dimer interface [polypeptide binding]; other site 208964014976 phosphorylation site [posttranslational modification] 208964014977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964014978 ATP binding site [chemical binding]; other site 208964014979 Mg2+ binding site [ion binding]; other site 208964014980 G-X-G motif; other site 208964014981 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964014982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964014983 active site 208964014984 phosphorylation site [posttranslational modification] 208964014985 intermolecular recognition site; other site 208964014986 dimerization interface [polypeptide binding]; other site 208964014987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964014988 Walker A motif; other site 208964014989 ATP binding site [chemical binding]; other site 208964014990 Walker B motif; other site 208964014991 arginine finger; other site 208964014992 poly(A) polymerase; Region: pcnB; TIGR01942 208964014993 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 208964014994 active site 208964014995 NTP binding site [chemical binding]; other site 208964014996 metal binding triad [ion binding]; metal-binding site 208964014997 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 208964014998 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 208964014999 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 208964015000 catalytic center binding site [active] 208964015001 ATP binding site [chemical binding]; other site 208964015002 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 208964015003 oligomerization interface [polypeptide binding]; other site 208964015004 active site 208964015005 metal binding site [ion binding]; metal-binding site 208964015006 Pantoate-beta-alanine ligase; Region: PanC; cd00560 208964015007 active site 208964015008 ATP-binding site [chemical binding]; other site 208964015009 pantoate-binding site; other site 208964015010 HXXH motif; other site 208964015011 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 208964015012 tetramerization interface [polypeptide binding]; other site 208964015013 active site 208964015014 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 208964015015 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 208964015016 active site 208964015017 dimer interface [polypeptide binding]; other site 208964015018 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 208964015019 dimer interface [polypeptide binding]; other site 208964015020 active site 208964015021 acetyl-CoA synthetase; Provisional; Region: PRK00174 208964015022 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 208964015023 active site 208964015024 CoA binding site [chemical binding]; other site 208964015025 acyl-activating enzyme (AAE) consensus motif; other site 208964015026 AMP binding site [chemical binding]; other site 208964015027 acetate binding site [chemical binding]; other site 208964015028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 208964015029 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 208964015030 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 208964015031 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 208964015032 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 208964015033 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 208964015034 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 208964015035 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 208964015036 CsbD-like; Region: CsbD; cl17424 208964015037 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 208964015038 BON domain; Region: BON; pfam04972 208964015039 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 208964015040 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 208964015041 RNase E interface [polypeptide binding]; other site 208964015042 trimer interface [polypeptide binding]; other site 208964015043 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 208964015044 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 208964015045 RNase E interface [polypeptide binding]; other site 208964015046 trimer interface [polypeptide binding]; other site 208964015047 active site 208964015048 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 208964015049 putative nucleic acid binding region [nucleotide binding]; other site 208964015050 G-X-X-G motif; other site 208964015051 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 208964015052 RNA binding site [nucleotide binding]; other site 208964015053 domain interface; other site 208964015054 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 208964015055 16S/18S rRNA binding site [nucleotide binding]; other site 208964015056 S13e-L30e interaction site [polypeptide binding]; other site 208964015057 25S rRNA binding site [nucleotide binding]; other site 208964015058 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 208964015059 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 208964015060 RNA binding site [nucleotide binding]; other site 208964015061 active site 208964015062 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 208964015063 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 208964015064 translation initiation factor IF-2; Validated; Region: infB; PRK05306 208964015065 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 208964015066 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 208964015067 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 208964015068 G1 box; other site 208964015069 putative GEF interaction site [polypeptide binding]; other site 208964015070 GTP/Mg2+ binding site [chemical binding]; other site 208964015071 Switch I region; other site 208964015072 G2 box; other site 208964015073 G3 box; other site 208964015074 Switch II region; other site 208964015075 G4 box; other site 208964015076 G5 box; other site 208964015077 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 208964015078 Translation-initiation factor 2; Region: IF-2; pfam11987 208964015079 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 208964015080 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 208964015081 NusA N-terminal domain; Region: NusA_N; pfam08529 208964015082 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 208964015083 RNA binding site [nucleotide binding]; other site 208964015084 homodimer interface [polypeptide binding]; other site 208964015085 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 208964015086 G-X-X-G motif; other site 208964015087 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 208964015088 G-X-X-G motif; other site 208964015089 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 208964015090 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 208964015091 Sm and related proteins; Region: Sm_like; cl00259 208964015092 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 208964015093 putative oligomer interface [polypeptide binding]; other site 208964015094 putative RNA binding site [nucleotide binding]; other site 208964015095 Preprotein translocase SecG subunit; Region: SecG; pfam03840 208964015096 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 208964015097 substrate binding site [chemical binding]; other site 208964015098 dimer interface [polypeptide binding]; other site 208964015099 catalytic triad [active] 208964015100 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 208964015101 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 208964015102 active site 208964015103 substrate binding site [chemical binding]; other site 208964015104 metal binding site [ion binding]; metal-binding site 208964015105 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 208964015106 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 208964015107 substrate binding pocket [chemical binding]; other site 208964015108 dimer interface [polypeptide binding]; other site 208964015109 inhibitor binding site; inhibition site 208964015110 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 208964015111 FtsH Extracellular; Region: FtsH_ext; pfam06480 208964015112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964015113 Walker A motif; other site 208964015114 ATP binding site [chemical binding]; other site 208964015115 Walker B motif; other site 208964015116 arginine finger; other site 208964015117 Peptidase family M41; Region: Peptidase_M41; pfam01434 208964015118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964015119 S-adenosylmethionine binding site [chemical binding]; other site 208964015120 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 208964015121 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 208964015122 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 208964015123 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 208964015124 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 208964015125 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208964015126 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 208964015127 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 208964015128 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208964015129 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964015130 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 208964015131 IMP binding site; other site 208964015132 dimer interface [polypeptide binding]; other site 208964015133 interdomain contacts; other site 208964015134 partial ornithine binding site; other site 208964015135 leucine export protein LeuE; Provisional; Region: PRK10958 208964015136 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 208964015137 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 208964015138 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 208964015139 catalytic site [active] 208964015140 subunit interface [polypeptide binding]; other site 208964015141 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 208964015142 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 208964015143 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 208964015144 chaperone protein DnaJ; Provisional; Region: PRK10767 208964015145 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 208964015146 HSP70 interaction site [polypeptide binding]; other site 208964015147 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 208964015148 substrate binding site [polypeptide binding]; other site 208964015149 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 208964015150 Zn binding sites [ion binding]; other site 208964015151 dimer interface [polypeptide binding]; other site 208964015152 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 208964015153 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 208964015154 nucleotide binding site [chemical binding]; other site 208964015155 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 208964015156 dimer interface [polypeptide binding]; other site 208964015157 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 208964015158 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 208964015159 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 208964015160 Walker A/P-loop; other site 208964015161 ATP binding site [chemical binding]; other site 208964015162 Q-loop/lid; other site 208964015163 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 208964015164 ABC transporter signature motif; other site 208964015165 Walker B; other site 208964015166 D-loop; other site 208964015167 H-loop/switch region; other site 208964015168 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 208964015169 metal binding site 2 [ion binding]; metal-binding site 208964015170 putative DNA binding helix; other site 208964015171 metal binding site 1 [ion binding]; metal-binding site 208964015172 dimer interface [polypeptide binding]; other site 208964015173 structural Zn2+ binding site [ion binding]; other site 208964015174 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 208964015175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 208964015176 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 208964015177 putative coenzyme Q binding site [chemical binding]; other site 208964015178 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 208964015179 SmpB-tmRNA interface; other site 208964015180 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 208964015181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964015182 DNA-binding site [nucleotide binding]; DNA binding site 208964015183 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 208964015184 L-lactate permease; Region: Lactate_perm; cl00701 208964015185 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 208964015186 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 208964015187 active site 208964015188 substrate binding site [chemical binding]; other site 208964015189 FMN binding site [chemical binding]; other site 208964015190 putative catalytic residues [active] 208964015191 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 208964015192 FAD binding domain; Region: FAD_binding_4; pfam01565 208964015193 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 208964015194 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 208964015195 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 208964015196 Cysteine-rich domain; Region: CCG; pfam02754 208964015197 Cysteine-rich domain; Region: CCG; pfam02754 208964015198 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 208964015199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964015200 S-adenosylmethionine binding site [chemical binding]; other site 208964015201 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 208964015202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964015203 active site 208964015204 phosphorylation site [posttranslational modification] 208964015205 intermolecular recognition site; other site 208964015206 dimerization interface [polypeptide binding]; other site 208964015207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964015208 DNA binding site [nucleotide binding] 208964015209 sensor protein QseC; Provisional; Region: PRK10337 208964015210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964015211 dimer interface [polypeptide binding]; other site 208964015212 phosphorylation site [posttranslational modification] 208964015213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964015214 ATP binding site [chemical binding]; other site 208964015215 Mg2+ binding site [ion binding]; other site 208964015216 G-X-G motif; other site 208964015217 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 208964015218 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 208964015219 DNA binding residues [nucleotide binding] 208964015220 dimer interface [polypeptide binding]; other site 208964015221 copper binding site [ion binding]; other site 208964015222 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 208964015223 EamA-like transporter family; Region: EamA; pfam00892 208964015224 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 208964015225 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 208964015226 ATP binding site [chemical binding]; other site 208964015227 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 208964015228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964015229 active site 208964015230 phosphorylation site [posttranslational modification] 208964015231 intermolecular recognition site; other site 208964015232 dimerization interface [polypeptide binding]; other site 208964015233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964015234 Zn2+ binding site [ion binding]; other site 208964015235 Mg2+ binding site [ion binding]; other site 208964015236 Protein of unknown function (DUF690); Region: DUF690; cl04939 208964015237 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 208964015238 EamA-like transporter family; Region: EamA; pfam00892 208964015239 EamA-like transporter family; Region: EamA; pfam00892 208964015240 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964015241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964015242 putative DNA binding site [nucleotide binding]; other site 208964015243 putative Zn2+ binding site [ion binding]; other site 208964015244 AsnC family; Region: AsnC_trans_reg; pfam01037 208964015245 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 208964015246 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208964015247 dimer interface [polypeptide binding]; other site 208964015248 active site 208964015249 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 208964015250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964015251 NAD(P) binding site [chemical binding]; other site 208964015252 active site 208964015253 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964015254 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964015255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964015256 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 208964015257 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 208964015258 active site 2 [active] 208964015259 active site 1 [active] 208964015260 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 208964015261 homodimer interface [polypeptide binding]; other site 208964015262 chemical substrate binding site [chemical binding]; other site 208964015263 oligomer interface [polypeptide binding]; other site 208964015264 metal binding site [ion binding]; metal-binding site 208964015265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964015266 S-adenosylmethionine binding site [chemical binding]; other site 208964015267 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 208964015268 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 208964015269 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 208964015270 putative active site [active] 208964015271 catalytic site [active] 208964015272 putative metal binding site [ion binding]; other site 208964015273 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 208964015274 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208964015275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964015276 Coenzyme A binding pocket [chemical binding]; other site 208964015277 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 208964015278 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 208964015279 lipoyl attachment site [posttranslational modification]; other site 208964015280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 208964015281 Transposase; Region: DEDD_Tnp_IS110; pfam01548 208964015282 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 208964015283 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 208964015284 GrpB protein; Region: GrpB; pfam04229 208964015285 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 208964015286 AAA domain; Region: AAA_17; pfam13207 208964015287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964015288 S-adenosylmethionine binding site [chemical binding]; other site 208964015289 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 208964015290 active site 208964015291 catalytic triad [active] 208964015292 dimer interface [polypeptide binding]; other site 208964015293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964015294 S-adenosylmethionine binding site [chemical binding]; other site 208964015295 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208964015296 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964015297 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964015298 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964015299 inhibitor-cofactor binding pocket; inhibition site 208964015300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964015301 catalytic residue [active] 208964015302 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208964015303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208964015304 DNA binding residues [nucleotide binding] 208964015305 dimerization interface [polypeptide binding]; other site 208964015306 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 208964015307 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 208964015308 G1 box; other site 208964015309 putative GEF interaction site [polypeptide binding]; other site 208964015310 GTP/Mg2+ binding site [chemical binding]; other site 208964015311 Switch I region; other site 208964015312 G2 box; other site 208964015313 G3 box; other site 208964015314 Switch II region; other site 208964015315 G4 box; other site 208964015316 G5 box; other site 208964015317 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 208964015318 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 208964015319 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 208964015320 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 208964015321 selenocysteine synthase; Provisional; Region: PRK04311 208964015322 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 208964015323 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 208964015324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208964015325 catalytic residue [active] 208964015326 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 208964015327 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 208964015328 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 208964015329 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 208964015330 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 208964015331 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 208964015332 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 208964015333 [4Fe-4S] binding site [ion binding]; other site 208964015334 molybdopterin cofactor binding site; other site 208964015335 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 208964015336 molybdopterin cofactor binding site; other site 208964015337 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 208964015338 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 208964015339 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 208964015340 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 208964015341 active site 208964015342 FMN binding site [chemical binding]; other site 208964015343 2,4-decadienoyl-CoA binding site; other site 208964015344 catalytic residue [active] 208964015345 4Fe-4S cluster binding site [ion binding]; other site 208964015346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964015347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 208964015348 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 208964015349 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 208964015350 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 208964015351 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 208964015352 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 208964015353 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 208964015354 Ligand binding site; other site 208964015355 Putative Catalytic site; other site 208964015356 DXD motif; other site 208964015357 GtrA-like protein; Region: GtrA; pfam04138 208964015358 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 208964015359 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 208964015360 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 208964015361 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 208964015362 PhoU domain; Region: PhoU; pfam01895 208964015363 PhoU domain; Region: PhoU; pfam01895 208964015364 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 208964015365 magnesium-transporting ATPase; Provisional; Region: PRK15122 208964015366 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 208964015367 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208964015368 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 208964015369 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 208964015370 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208964015371 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 208964015372 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 208964015373 Predicted membrane protein [Function unknown]; Region: COG3556 208964015374 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 208964015375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964015376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964015377 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 208964015378 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964015379 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 208964015380 CoenzymeA binding site [chemical binding]; other site 208964015381 subunit interaction site [polypeptide binding]; other site 208964015382 PHB binding site; other site 208964015383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964015384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964015385 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 208964015386 classical (c) SDRs; Region: SDR_c; cd05233 208964015387 NAD(P) binding site [chemical binding]; other site 208964015388 active site 208964015389 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 208964015390 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 208964015391 EamA-like transporter family; Region: EamA; pfam00892 208964015392 EamA-like transporter family; Region: EamA; pfam00892 208964015393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 208964015394 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964015395 Nicotianamine synthase protein; Region: NAS; cl17658 208964015396 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 208964015397 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 208964015398 N-terminal plug; other site 208964015399 ligand-binding site [chemical binding]; other site 208964015400 Predicted membrane protein [Function unknown]; Region: COG3503 208964015401 arginine decarboxylase; Provisional; Region: PRK05354 208964015402 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 208964015403 dimer interface [polypeptide binding]; other site 208964015404 active site 208964015405 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208964015406 catalytic residues [active] 208964015407 substrate binding site [chemical binding]; other site 208964015408 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 208964015409 putative rRNA binding site [nucleotide binding]; other site 208964015410 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 208964015411 nudix motif; other site 208964015412 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 208964015413 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 208964015414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964015415 active site 208964015416 phosphorylation site [posttranslational modification] 208964015417 intermolecular recognition site; other site 208964015418 dimerization interface [polypeptide binding]; other site 208964015419 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964015420 metal binding site [ion binding]; metal-binding site 208964015421 active site 208964015422 I-site; other site 208964015423 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964015424 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964015425 dimer interface [polypeptide binding]; other site 208964015426 putative CheW interface [polypeptide binding]; other site 208964015427 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 208964015428 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 208964015429 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 208964015430 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 208964015431 DsbD alpha interface [polypeptide binding]; other site 208964015432 catalytic residues [active] 208964015433 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 208964015434 trimer interface [polypeptide binding]; other site 208964015435 active site 208964015436 dimer interface [polypeptide binding]; other site 208964015437 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 208964015438 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208964015439 carboxyltransferase (CT) interaction site; other site 208964015440 biotinylation site [posttranslational modification]; other site 208964015441 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 208964015442 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208964015443 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 208964015444 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 208964015445 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 208964015446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964015447 S-adenosylmethionine binding site [chemical binding]; other site 208964015448 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 208964015449 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 208964015450 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 208964015451 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 208964015452 FMN binding site [chemical binding]; other site 208964015453 active site 208964015454 catalytic residues [active] 208964015455 substrate binding site [chemical binding]; other site 208964015456 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 208964015457 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 208964015458 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 208964015459 purine monophosphate binding site [chemical binding]; other site 208964015460 dimer interface [polypeptide binding]; other site 208964015461 putative catalytic residues [active] 208964015462 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 208964015463 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 208964015464 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 208964015465 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 208964015466 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 208964015467 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 208964015468 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 208964015469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964015470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964015471 dimer interface [polypeptide binding]; other site 208964015472 phosphorylation site [posttranslational modification] 208964015473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964015474 ATP binding site [chemical binding]; other site 208964015475 Mg2+ binding site [ion binding]; other site 208964015476 G-X-G motif; other site 208964015477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964015478 active site 208964015479 phosphorylation site [posttranslational modification] 208964015480 intermolecular recognition site; other site 208964015481 dimerization interface [polypeptide binding]; other site 208964015482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964015483 active site 208964015484 phosphorylation site [posttranslational modification] 208964015485 intermolecular recognition site; other site 208964015486 dimerization interface [polypeptide binding]; other site 208964015487 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 208964015488 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 208964015489 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 208964015490 putative ligand binding site [chemical binding]; other site 208964015491 HEAT repeats; Region: HEAT_2; pfam13646 208964015492 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 208964015493 TM-ABC transporter signature motif; other site 208964015494 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 208964015495 TM-ABC transporter signature motif; other site 208964015496 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 208964015497 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 208964015498 Walker A/P-loop; other site 208964015499 ATP binding site [chemical binding]; other site 208964015500 Q-loop/lid; other site 208964015501 ABC transporter signature motif; other site 208964015502 Walker B; other site 208964015503 D-loop; other site 208964015504 H-loop/switch region; other site 208964015505 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 208964015506 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 208964015507 Walker A/P-loop; other site 208964015508 ATP binding site [chemical binding]; other site 208964015509 Q-loop/lid; other site 208964015510 ABC transporter signature motif; other site 208964015511 Walker B; other site 208964015512 D-loop; other site 208964015513 H-loop/switch region; other site 208964015514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964015515 Coenzyme A binding pocket [chemical binding]; other site 208964015516 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 208964015517 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 208964015518 alpha-gamma subunit interface [polypeptide binding]; other site 208964015519 beta-gamma subunit interface [polypeptide binding]; other site 208964015520 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208964015521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964015522 Coenzyme A binding pocket [chemical binding]; other site 208964015523 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 208964015524 gamma-beta subunit interface [polypeptide binding]; other site 208964015525 alpha-beta subunit interface [polypeptide binding]; other site 208964015526 urease subunit alpha; Reviewed; Region: ureC; PRK13207 208964015527 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 208964015528 subunit interactions [polypeptide binding]; other site 208964015529 active site 208964015530 flap region; other site 208964015531 hypothetical protein; Provisional; Region: PRK11019 208964015532 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 208964015533 tetramer interface [polypeptide binding]; other site 208964015534 active site 208964015535 Mg2+/Mn2+ binding site [ion binding]; other site 208964015536 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 208964015537 putative chaperone; Provisional; Region: PRK11678 208964015538 nucleotide binding site [chemical binding]; other site 208964015539 putative NEF/HSP70 interaction site [polypeptide binding]; other site 208964015540 SBD interface [polypeptide binding]; other site 208964015541 psiF repeat; Region: PsiF_repeat; pfam07769 208964015542 psiF repeat; Region: PsiF_repeat; pfam07769 208964015543 psiF repeat; Region: PsiF_repeat; pfam07769 208964015544 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 208964015545 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 208964015546 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 208964015547 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 208964015548 DNA binding residues [nucleotide binding] 208964015549 drug binding residues [chemical binding]; other site 208964015550 dimer interface [polypeptide binding]; other site 208964015551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 208964015552 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 208964015553 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 208964015554 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 208964015555 Ferritin-like domain; Region: Ferritin; pfam00210 208964015556 dinuclear metal binding motif [ion binding]; other site 208964015557 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 208964015558 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 208964015559 Moco binding site; other site 208964015560 metal coordination site [ion binding]; other site 208964015561 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 208964015562 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 208964015563 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 208964015564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964015565 active site 208964015566 phosphorylation site [posttranslational modification] 208964015567 intermolecular recognition site; other site 208964015568 dimerization interface [polypeptide binding]; other site 208964015569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964015570 DNA binding site [nucleotide binding] 208964015571 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 208964015572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964015573 dimerization interface [polypeptide binding]; other site 208964015574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964015575 dimer interface [polypeptide binding]; other site 208964015576 phosphorylation site [posttranslational modification] 208964015577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964015578 ATP binding site [chemical binding]; other site 208964015579 Mg2+ binding site [ion binding]; other site 208964015580 G-X-G motif; other site 208964015581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964015582 putative MFS family transporter protein; Provisional; Region: PRK03633 208964015583 putative substrate translocation pore; other site 208964015584 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 208964015585 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 208964015586 putative di-iron ligands [ion binding]; other site 208964015587 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 208964015588 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 208964015589 FAD binding pocket [chemical binding]; other site 208964015590 FAD binding motif [chemical binding]; other site 208964015591 phosphate binding motif [ion binding]; other site 208964015592 beta-alpha-beta structure motif; other site 208964015593 NAD binding pocket [chemical binding]; other site 208964015594 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964015595 catalytic loop [active] 208964015596 iron binding site [ion binding]; other site 208964015597 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 208964015598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964015599 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 208964015600 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 208964015601 dimer interface [polypeptide binding]; other site 208964015602 catalytic residues [active] 208964015603 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 208964015604 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 208964015605 G1 box; other site 208964015606 GTP/Mg2+ binding site [chemical binding]; other site 208964015607 G2 box; other site 208964015608 Switch I region; other site 208964015609 G3 box; other site 208964015610 Switch II region; other site 208964015611 G4 box; other site 208964015612 G5 box; other site 208964015613 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 208964015614 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 208964015615 FecR protein; Region: FecR; pfam04773 208964015616 RNA polymerase sigma factor; Provisional; Region: PRK12529 208964015617 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208964015618 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 208964015619 DNA binding residues [nucleotide binding] 208964015620 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964015621 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 208964015622 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 208964015623 outer membrane porin, OprD family; Region: OprD; pfam03573 208964015624 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 208964015625 NAD(P) binding site [chemical binding]; other site 208964015626 catalytic residues [active] 208964015627 benzoate transport; Region: 2A0115; TIGR00895 208964015628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964015629 putative substrate translocation pore; other site 208964015630 benzoylformate decarboxylase; Reviewed; Region: PRK07092 208964015631 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 208964015632 PYR/PP interface [polypeptide binding]; other site 208964015633 dimer interface [polypeptide binding]; other site 208964015634 TPP binding site [chemical binding]; other site 208964015635 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964015636 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 208964015637 TPP-binding site [chemical binding]; other site 208964015638 dimer interface [polypeptide binding]; other site 208964015639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964015640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964015641 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 208964015642 substrate binding pocket [chemical binding]; other site 208964015643 dimerization interface [polypeptide binding]; other site 208964015644 benzoate transport; Region: 2A0115; TIGR00895 208964015645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964015646 putative substrate translocation pore; other site 208964015647 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 208964015648 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 208964015649 iron-sulfur cluster [ion binding]; other site 208964015650 [2Fe-2S] cluster binding site [ion binding]; other site 208964015651 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 208964015652 alpha subunit interface [polypeptide binding]; other site 208964015653 active site 208964015654 substrate binding site [chemical binding]; other site 208964015655 Fe binding site [ion binding]; other site 208964015656 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 208964015657 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 208964015658 FMN-binding pocket [chemical binding]; other site 208964015659 flavin binding motif; other site 208964015660 phosphate binding motif [ion binding]; other site 208964015661 beta-alpha-beta structure motif; other site 208964015662 NAD binding pocket [chemical binding]; other site 208964015663 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964015664 catalytic loop [active] 208964015665 iron binding site [ion binding]; other site 208964015666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964015667 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 208964015668 DNA-binding site [nucleotide binding]; DNA binding site 208964015669 FCD domain; Region: FCD; pfam07729 208964015670 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 208964015671 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 208964015672 putative NAD(P) binding site [chemical binding]; other site 208964015673 homodimer interface [polypeptide binding]; other site 208964015674 homotetramer interface [polypeptide binding]; other site 208964015675 active site 208964015676 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 208964015677 ornithine cyclodeaminase; Validated; Region: PRK06141 208964015678 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 208964015679 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 208964015680 Walker A/P-loop; other site 208964015681 ATP binding site [chemical binding]; other site 208964015682 Q-loop/lid; other site 208964015683 ABC transporter signature motif; other site 208964015684 Walker B; other site 208964015685 D-loop; other site 208964015686 H-loop/switch region; other site 208964015687 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 208964015688 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 208964015689 Walker A/P-loop; other site 208964015690 ATP binding site [chemical binding]; other site 208964015691 Q-loop/lid; other site 208964015692 ABC transporter signature motif; other site 208964015693 Walker B; other site 208964015694 D-loop; other site 208964015695 H-loop/switch region; other site 208964015696 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 208964015697 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 208964015698 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 208964015699 TM-ABC transporter signature motif; other site 208964015700 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 208964015701 TM-ABC transporter signature motif; other site 208964015702 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 208964015703 dimerization interface [polypeptide binding]; other site 208964015704 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 208964015705 ligand binding site [chemical binding]; other site 208964015706 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964015707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964015708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964015709 dimerization interface [polypeptide binding]; other site 208964015710 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 208964015711 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964015712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964015713 dimerization interface [polypeptide binding]; other site 208964015714 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964015715 dimer interface [polypeptide binding]; other site 208964015716 putative CheW interface [polypeptide binding]; other site 208964015717 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 208964015718 nudix motif; other site 208964015719 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 208964015720 active site 208964015721 nucleotide binding site [chemical binding]; other site 208964015722 HIGH motif; other site 208964015723 KMSKS motif; other site 208964015724 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 208964015725 catalytic triad [active] 208964015726 metal binding site [ion binding]; metal-binding site 208964015727 conserved cis-peptide bond; other site 208964015728 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 208964015729 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 208964015730 active site 208964015731 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 208964015732 homodimer interface [polypeptide binding]; other site 208964015733 NAD binding pocket [chemical binding]; other site 208964015734 ATP binding pocket [chemical binding]; other site 208964015735 Mg binding site [ion binding]; other site 208964015736 active-site loop [active] 208964015737 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 208964015738 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 208964015739 active site 208964015740 catalytic triad [active] 208964015741 oxyanion hole [active] 208964015742 Azurin is a redox partner for enzymes such as nitrite reductase or arsenite oxidase; Region: Azurin; cd13922 208964015743 Type 1 (T1) Cu binding site [ion binding]; other site 208964015744 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 208964015745 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208964015746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964015747 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964015748 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 208964015749 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208964015750 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 208964015751 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 208964015752 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 208964015753 Uncharacterized conserved protein [Function unknown]; Region: COG2308 208964015754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 208964015755 hypothetical protein; Provisional; Region: PRK01254 208964015756 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 208964015757 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 208964015758 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 208964015759 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 208964015760 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 208964015761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964015762 metal binding site [ion binding]; metal-binding site 208964015763 active site 208964015764 I-site; other site 208964015765 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 208964015766 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 208964015767 active site 208964015768 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208964015769 substrate binding site [chemical binding]; other site 208964015770 catalytic residues [active] 208964015771 dimer interface [polypeptide binding]; other site 208964015772 replicative DNA helicase; Provisional; Region: PRK05748 208964015773 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 208964015774 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 208964015775 Walker A motif; other site 208964015776 ATP binding site [chemical binding]; other site 208964015777 Walker B motif; other site 208964015778 DNA binding loops [nucleotide binding] 208964015779 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 208964015780 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 208964015781 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 208964015782 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 208964015783 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 208964015784 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 208964015785 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 208964015786 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 208964015787 exoribonuclease R; Provisional; Region: PRK11642 208964015788 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 208964015789 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 208964015790 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 208964015791 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 208964015792 RNA binding site [nucleotide binding]; other site 208964015793 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 208964015794 GDP-binding site [chemical binding]; other site 208964015795 ACT binding site; other site 208964015796 IMP binding site; other site 208964015797 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 208964015798 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 208964015799 dimer interface [polypeptide binding]; other site 208964015800 motif 1; other site 208964015801 active site 208964015802 motif 2; other site 208964015803 motif 3; other site 208964015804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 208964015805 HflC protein; Region: hflC; TIGR01932 208964015806 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 208964015807 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 208964015808 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 208964015809 HflK protein; Region: hflK; TIGR01933 208964015810 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 208964015811 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 208964015812 HflX GTPase family; Region: HflX; cd01878 208964015813 G1 box; other site 208964015814 GTP/Mg2+ binding site [chemical binding]; other site 208964015815 Switch I region; other site 208964015816 G2 box; other site 208964015817 G3 box; other site 208964015818 Switch II region; other site 208964015819 G4 box; other site 208964015820 G5 box; other site 208964015821 bacterial Hfq-like; Region: Hfq; cd01716 208964015822 hexamer interface [polypeptide binding]; other site 208964015823 Sm1 motif; other site 208964015824 RNA binding site [nucleotide binding]; other site 208964015825 Sm2 motif; other site 208964015826 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 208964015827 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 208964015828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964015829 ATP binding site [chemical binding]; other site 208964015830 Mg2+ binding site [ion binding]; other site 208964015831 G-X-G motif; other site 208964015832 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 208964015833 ATP binding site [chemical binding]; other site 208964015834 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 208964015835 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 208964015836 AMIN domain; Region: AMIN; pfam11741 208964015837 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 208964015838 active site 208964015839 metal binding site [ion binding]; metal-binding site 208964015840 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 208964015841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964015842 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 208964015843 putative carbohydrate kinase; Provisional; Region: PRK10565 208964015844 Uncharacterized conserved protein [Function unknown]; Region: COG0062 208964015845 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 208964015846 putative substrate binding site [chemical binding]; other site 208964015847 putative ATP binding site [chemical binding]; other site 208964015848 epoxyqueuosine reductase; Region: TIGR00276 208964015849 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 208964015850 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 208964015851 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 208964015852 catalytic site [active] 208964015853 putative active site [active] 208964015854 putative substrate binding site [chemical binding]; other site 208964015855 dimer interface [polypeptide binding]; other site 208964015856 GTPase RsgA; Reviewed; Region: PRK12288 208964015857 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 208964015858 RNA binding site [nucleotide binding]; other site 208964015859 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 208964015860 GTPase/Zn-binding domain interface [polypeptide binding]; other site 208964015861 GTP/Mg2+ binding site [chemical binding]; other site 208964015862 G4 box; other site 208964015863 G5 box; other site 208964015864 G1 box; other site 208964015865 G3 box; other site 208964015866 Switch II region; other site 208964015867 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 208964015868 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 208964015869 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 208964015870 ligand binding site [chemical binding]; other site 208964015871 flagellar motor protein MotA; Validated; Region: PRK09110 208964015872 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 208964015873 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 208964015874 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 208964015875 active site residue [active] 208964015876 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 208964015877 active site residue [active] 208964015878 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 208964015879 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 208964015880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208964015881 active site 208964015882 phosphorylation site [posttranslational modification] 208964015883 dimerization interface [polypeptide binding]; other site 208964015884 PAS fold; Region: PAS; pfam00989 208964015885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964015886 putative active site [active] 208964015887 heme pocket [chemical binding]; other site 208964015888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964015889 metal binding site [ion binding]; metal-binding site 208964015890 active site 208964015891 I-site; other site 208964015892 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964015893 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 208964015894 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 208964015895 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 208964015896 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 208964015897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964015898 motif II; other site 208964015899 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 208964015900 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 208964015901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 208964015902 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 208964015903 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 208964015904 CAP-like domain; other site 208964015905 active site 208964015906 primary dimer interface [polypeptide binding]; other site 208964015907 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 208964015908 catalytic motif [active] 208964015909 Catalytic residue [active] 208964015910 SdiA-regulated; Region: SdiA-regulated; cl19046 208964015911 putative active site [active] 208964015912 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 208964015913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964015914 ATP binding site [chemical binding]; other site 208964015915 Mg2+ binding site [ion binding]; other site 208964015916 G-X-G motif; other site 208964015917 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 208964015918 anchoring element; other site 208964015919 dimer interface [polypeptide binding]; other site 208964015920 ATP binding site [chemical binding]; other site 208964015921 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 208964015922 active site 208964015923 metal binding site [ion binding]; metal-binding site 208964015924 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 208964015925 Predicted esterase [General function prediction only]; Region: COG3150 208964015926 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208964015927 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 208964015928 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 208964015929 active site 208964015930 metal binding site [ion binding]; metal-binding site 208964015931 hexamer interface [polypeptide binding]; other site 208964015932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3151 208964015933 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 208964015934 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 208964015935 dimer interface [polypeptide binding]; other site 208964015936 ADP-ribose binding site [chemical binding]; other site 208964015937 active site 208964015938 nudix motif; other site 208964015939 metal binding site [ion binding]; metal-binding site 208964015940 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 208964015941 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 208964015942 ThiC-associated domain; Region: ThiC-associated; pfam13667 208964015943 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 208964015944 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 208964015945 Outer membrane efflux protein; Region: OEP; pfam02321 208964015946 Outer membrane efflux protein; Region: OEP; pfam02321 208964015947 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 208964015948 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 208964015949 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964015950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964015951 homodimer interface [polypeptide binding]; other site 208964015952 catalytic residue [active] 208964015953 hypothetical protein; Provisional; Region: PRK07524 208964015954 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 208964015955 PYR/PP interface [polypeptide binding]; other site 208964015956 dimer interface [polypeptide binding]; other site 208964015957 TPP binding site [chemical binding]; other site 208964015958 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964015959 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 208964015960 TPP-binding site [chemical binding]; other site 208964015961 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 208964015962 CoA binding domain; Region: CoA_binding_2; pfam13380 208964015963 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 208964015964 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 208964015965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964015966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964015967 active site 208964015968 enoyl-CoA hydratase; Provisional; Region: PRK06688 208964015969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208964015970 substrate binding site [chemical binding]; other site 208964015971 oxyanion hole (OAH) forming residues; other site 208964015972 trimer interface [polypeptide binding]; other site 208964015973 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 208964015974 S-methylmethionine transporter; Provisional; Region: PRK11387 208964015975 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964015976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208964015977 HAMP domain; Region: HAMP; pfam00672 208964015978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964015979 dimer interface [polypeptide binding]; other site 208964015980 phosphorylation site [posttranslational modification] 208964015981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964015982 ATP binding site [chemical binding]; other site 208964015983 Mg2+ binding site [ion binding]; other site 208964015984 G-X-G motif; other site 208964015985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964015986 active site 208964015987 phosphorylation site [posttranslational modification] 208964015988 intermolecular recognition site; other site 208964015989 dimerization interface [polypeptide binding]; other site 208964015990 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 208964015991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964015992 active site 208964015993 phosphorylation site [posttranslational modification] 208964015994 intermolecular recognition site; other site 208964015995 dimerization interface [polypeptide binding]; other site 208964015996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964015997 DNA binding site [nucleotide binding] 208964015998 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 208964015999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964016000 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 208964016001 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208964016002 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 208964016003 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 208964016004 putative active site [active] 208964016005 putative FMN binding site [chemical binding]; other site 208964016006 putative substrate binding site [chemical binding]; other site 208964016007 putative catalytic residue [active] 208964016008 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 208964016009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964016010 non-specific DNA binding site [nucleotide binding]; other site 208964016011 salt bridge; other site 208964016012 sequence-specific DNA binding site [nucleotide binding]; other site 208964016013 Cupin domain; Region: Cupin_2; pfam07883 208964016014 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 208964016015 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 208964016016 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 208964016017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964016018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964016019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964016020 dimerization interface [polypeptide binding]; other site 208964016021 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 208964016022 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 208964016023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208964016024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964016025 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208964016026 active site 208964016027 catalytic tetrad [active] 208964016028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964016029 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964016030 active site 208964016031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208964016032 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964016033 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 208964016034 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 208964016035 putative ribose interaction site [chemical binding]; other site 208964016036 putative ADP binding site [chemical binding]; other site 208964016037 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 208964016038 active site 208964016039 nucleotide binding site [chemical binding]; other site 208964016040 HIGH motif; other site 208964016041 KMSKS motif; other site 208964016042 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 208964016043 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208964016044 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 208964016045 Walker A/P-loop; other site 208964016046 ATP binding site [chemical binding]; other site 208964016047 Q-loop/lid; other site 208964016048 ABC transporter signature motif; other site 208964016049 Walker B; other site 208964016050 D-loop; other site 208964016051 H-loop/switch region; other site 208964016052 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 208964016053 active site 208964016054 substrate binding site [chemical binding]; other site 208964016055 ATP binding site [chemical binding]; other site 208964016056 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 208964016057 O-Antigen ligase; Region: Wzy_C; pfam04932 208964016058 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 208964016059 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 208964016060 active site 208964016061 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 208964016062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964016063 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 208964016064 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 208964016065 Mig-14; Region: Mig-14; pfam07395 208964016066 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 208964016067 putative ADP-binding pocket [chemical binding]; other site 208964016068 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964016069 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 208964016070 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 208964016071 active site 208964016072 ATP binding site [chemical binding]; other site 208964016073 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 208964016074 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 208964016075 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 208964016076 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 208964016077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964016078 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208964016079 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 208964016080 putative active site [active] 208964016081 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 208964016082 putative active site [active] 208964016083 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 208964016084 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 208964016085 homodimer interface [polypeptide binding]; other site 208964016086 substrate-cofactor binding pocket; other site 208964016087 catalytic residue [active] 208964016088 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 208964016089 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 208964016090 metal binding triad; other site 208964016091 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 208964016092 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 208964016093 metal binding triad; other site 208964016094 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 208964016095 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 208964016096 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 208964016097 dimer interface [polypeptide binding]; other site 208964016098 TPP-binding site [chemical binding]; other site 208964016099 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 208964016100 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348 208964016101 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 208964016102 E3 interaction surface; other site 208964016103 lipoyl attachment site [posttranslational modification]; other site 208964016104 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 208964016105 E3 interaction surface; other site 208964016106 lipoyl attachment site [posttranslational modification]; other site 208964016107 e3 binding domain; Region: E3_binding; pfam02817 208964016108 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 208964016109 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 208964016110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964016111 PAS domain; Region: PAS_9; pfam13426 208964016112 putative active site [active] 208964016113 heme pocket [chemical binding]; other site 208964016114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964016115 metal binding site [ion binding]; metal-binding site 208964016116 active site 208964016117 I-site; other site 208964016118 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964016119 methionine sulfoxide reductase A; Provisional; Region: PRK00058 208964016120 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 208964016121 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 208964016122 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 208964016123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964016124 active site 208964016125 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 208964016126 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 208964016127 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 208964016128 TrkA-C domain; Region: TrkA_C; pfam02080 208964016129 Transporter associated domain; Region: CorC_HlyC; smart01091 208964016130 hypothetical protein; Provisional; Region: PRK11281 208964016131 Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495 208964016132 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 208964016133 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208964016134 hypothetical protein; Validated; Region: PRK00029 208964016135 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 208964016136 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 208964016137 homodimer interface [polypeptide binding]; other site 208964016138 substrate-cofactor binding pocket; other site 208964016139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964016140 catalytic residue [active] 208964016141 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964016142 CoenzymeA binding site [chemical binding]; other site 208964016143 subunit interaction site [polypeptide binding]; other site 208964016144 PHB binding site; other site 208964016145 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964016146 Ligand Binding Site [chemical binding]; other site 208964016147 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208964016148 Ligand Binding Site [chemical binding]; other site 208964016149 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 208964016150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 208964016151 P-loop; other site 208964016152 Magnesium ion binding site [ion binding]; other site 208964016153 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 208964016154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964016155 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 208964016156 dimerization interface [polypeptide binding]; other site 208964016157 substrate binding pocket [chemical binding]; other site 208964016158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964016159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964016160 putative substrate translocation pore; other site 208964016161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964016162 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 208964016163 NAD(P) binding site [chemical binding]; other site 208964016164 active site 208964016165 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964016166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208964016167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964016168 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 208964016169 substrate binding site [chemical binding]; other site 208964016170 active site 208964016171 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 208964016172 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 208964016173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964016174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964016175 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 208964016176 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 208964016177 active site 208964016178 dimer interface [polypeptide binding]; other site 208964016179 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 208964016180 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 208964016181 active site 208964016182 FMN binding site [chemical binding]; other site 208964016183 substrate binding site [chemical binding]; other site 208964016184 3Fe-4S cluster binding site [ion binding]; other site 208964016185 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 208964016186 domain interface; other site 208964016187 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 208964016188 AAA domain; Region: AAA_22; pfam13401 208964016189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 208964016190 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 208964016191 Sporulation related domain; Region: SPOR; pfam05036 208964016192 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 208964016193 active site 208964016194 dimer interface [polypeptide binding]; other site 208964016195 metal binding site [ion binding]; metal-binding site 208964016196 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 208964016197 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 208964016198 ADP binding site [chemical binding]; other site 208964016199 magnesium binding site [ion binding]; other site 208964016200 putative shikimate binding site; other site 208964016201 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 208964016202 AMIN domain; Region: AMIN; pfam11741 208964016203 Secretin and TonB N terminus short domain; Region: STN; smart00965 208964016204 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 208964016205 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 208964016206 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 208964016207 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 208964016208 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 208964016209 Type IV pilus assembly protein PilM; Region: PilM_2; pfam11104 208964016210 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 208964016211 nucleotide binding site [chemical binding]; other site 208964016212 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 208964016213 Transglycosylase; Region: Transgly; pfam00912 208964016214 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 208964016215 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 208964016216 Malic enzyme, N-terminal domain; Region: malic; pfam00390 208964016217 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 208964016218 putative NAD(P) binding site [chemical binding]; other site 208964016219 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 208964016220 Peptidase family M48; Region: Peptidase_M48; pfam01435 208964016221 Staphylococcal nuclease homologues; Region: SNc; smart00318 208964016222 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 208964016223 Catalytic site; other site 208964016224 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 208964016225 primosome assembly protein PriA; Validated; Region: PRK05580 208964016226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964016227 ATP binding site [chemical binding]; other site 208964016228 putative Mg++ binding site [ion binding]; other site 208964016229 helicase superfamily c-terminal domain; Region: HELICc; smart00490 208964016230 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 208964016231 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 208964016232 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 208964016233 active site 208964016234 HIGH motif; other site 208964016235 KMSK motif region; other site 208964016236 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 208964016237 tRNA binding surface [nucleotide binding]; other site 208964016238 anticodon binding site; other site 208964016239 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 208964016240 Sporulation related domain; Region: SPOR; pfam05036 208964016241 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 208964016242 active site 208964016243 HslU subunit interaction site [polypeptide binding]; other site 208964016244 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 208964016245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964016246 Walker A motif; other site 208964016247 ATP binding site [chemical binding]; other site 208964016248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964016249 Walker B motif; other site 208964016250 arginine finger; other site 208964016251 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 208964016252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 208964016253 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 208964016254 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 208964016255 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 208964016256 catalytic site [active] 208964016257 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 208964016258 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964016259 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 208964016260 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 208964016261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208964016262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964016263 Bacterial transcriptional repressor; Region: TetR; pfam13972 208964016264 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 208964016265 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 208964016266 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 208964016267 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 208964016268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964016269 S-adenosylmethionine binding site [chemical binding]; other site 208964016270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 208964016271 ABC1 family; Region: ABC1; cl17513 208964016272 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 208964016273 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 208964016274 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 208964016275 metal binding site [ion binding]; metal-binding site 208964016276 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 208964016277 sec-independent translocase; Provisional; Region: tatB; PRK00404 208964016278 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 208964016279 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 208964016280 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 208964016281 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964016282 HAMP domain; Region: HAMP; pfam00672 208964016283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208964016284 dimer interface [polypeptide binding]; other site 208964016285 putative CheW interface [polypeptide binding]; other site 208964016286 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 208964016287 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208964016288 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208964016289 Walker A/P-loop; other site 208964016290 ATP binding site [chemical binding]; other site 208964016291 Q-loop/lid; other site 208964016292 ABC transporter signature motif; other site 208964016293 Walker B; other site 208964016294 D-loop; other site 208964016295 H-loop/switch region; other site 208964016296 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 208964016297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964016298 dimer interface [polypeptide binding]; other site 208964016299 conserved gate region; other site 208964016300 putative PBP binding loops; other site 208964016301 ABC-ATPase subunit interface; other site 208964016302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964016303 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964016304 substrate binding pocket [chemical binding]; other site 208964016305 membrane-bound complex binding site; other site 208964016306 hinge residues; other site 208964016307 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 208964016308 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 208964016309 Ligand binding site; other site 208964016310 DXD motif; other site 208964016311 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 208964016312 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 208964016313 putative active site [active] 208964016314 dimerization interface [polypeptide binding]; other site 208964016315 putative tRNAtyr binding site [nucleotide binding]; other site 208964016316 Putative lysophospholipase; Region: Hydrolase_4; cl19140 208964016317 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 208964016318 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 208964016319 nudix motif; other site 208964016320 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 208964016321 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964016322 substrate binding pocket [chemical binding]; other site 208964016323 membrane-bound complex binding site; other site 208964016324 hinge residues; other site 208964016325 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 208964016326 homotrimer interaction site [polypeptide binding]; other site 208964016327 putative active site [active] 208964016328 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 208964016329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964016330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964016331 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 208964016332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964016333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964016334 dimerization interface [polypeptide binding]; other site 208964016335 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 208964016336 Sel1-like repeats; Region: SEL1; smart00671 208964016337 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 208964016338 Sel1-like repeats; Region: SEL1; smart00671 208964016339 Sel1 repeat; Region: Sel1; pfam08238 208964016340 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 208964016341 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 208964016342 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 208964016343 putative active site [active] 208964016344 catalytic site [active] 208964016345 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 208964016346 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 208964016347 putative active site [active] 208964016348 catalytic site [active] 208964016349 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 208964016350 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964016351 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964016352 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 208964016353 N-formylglutamate amidohydrolase; Region: FGase; cl01522 208964016354 imidazolonepropionase; Validated; Region: PRK09356 208964016355 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 208964016356 active site 208964016357 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 208964016358 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 208964016359 active sites [active] 208964016360 tetramer interface [polypeptide binding]; other site 208964016361 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208964016362 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 208964016363 Walker A/P-loop; other site 208964016364 ATP binding site [chemical binding]; other site 208964016365 Q-loop/lid; other site 208964016366 ABC transporter signature motif; other site 208964016367 Walker B; other site 208964016368 D-loop; other site 208964016369 H-loop/switch region; other site 208964016370 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208964016371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964016372 dimer interface [polypeptide binding]; other site 208964016373 conserved gate region; other site 208964016374 putative PBP binding loops; other site 208964016375 ABC-ATPase subunit interface; other site 208964016376 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 208964016377 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 208964016378 Spore germination protein; Region: Spore_permease; cl17796 208964016379 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964016380 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 208964016381 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 208964016382 active sites [active] 208964016383 tetramer interface [polypeptide binding]; other site 208964016384 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 208964016385 Na binding site [ion binding]; other site 208964016386 urocanate hydratase; Provisional; Region: PRK05414 208964016387 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 208964016388 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 208964016389 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 208964016390 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 208964016391 putative di-iron ligands [ion binding]; other site 208964016392 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 208964016393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 208964016394 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 208964016395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964016396 DNA-binding site [nucleotide binding]; DNA binding site 208964016397 UTRA domain; Region: UTRA; pfam07702 208964016398 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 208964016399 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 208964016400 active site 208964016401 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 208964016402 SmpA / OmlA family; Region: SmpA_OmlA; cl19285 208964016403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 208964016404 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 208964016405 AMP binding site [chemical binding]; other site 208964016406 metal binding site [ion binding]; metal-binding site 208964016407 active site 208964016408 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 208964016409 dimer interface [polypeptide binding]; other site 208964016410 active site 208964016411 metal binding site [ion binding]; metal-binding site 208964016412 glutathione binding site [chemical binding]; other site 208964016413 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 208964016414 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 208964016415 active site 208964016416 catalytic triad [active] 208964016417 oxyanion hole [active] 208964016418 Autotransporter beta-domain; Region: Autotransporter; pfam03797 208964016419 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 208964016420 Predicted membrane protein [Function unknown]; Region: COG5373 208964016421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964016422 S-adenosylmethionine binding site [chemical binding]; other site 208964016423 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 208964016424 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 208964016425 DNA binding residues [nucleotide binding] 208964016426 putative dimer interface [polypeptide binding]; other site 208964016427 putative metal binding residues [ion binding]; other site 208964016428 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 208964016429 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 208964016430 G1 box; other site 208964016431 putative GEF interaction site [polypeptide binding]; other site 208964016432 GTP/Mg2+ binding site [chemical binding]; other site 208964016433 Switch I region; other site 208964016434 G2 box; other site 208964016435 G3 box; other site 208964016436 Switch II region; other site 208964016437 G4 box; other site 208964016438 G5 box; other site 208964016439 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 208964016440 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 208964016441 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 208964016442 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 208964016443 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 208964016444 Ligand Binding Site [chemical binding]; other site 208964016445 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 208964016446 glutamine synthetase; Provisional; Region: glnA; PRK09469 208964016447 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 208964016448 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208964016449 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 208964016450 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208964016451 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 208964016452 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 208964016453 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 208964016454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964016455 putative active site [active] 208964016456 heme pocket [chemical binding]; other site 208964016457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964016458 dimer interface [polypeptide binding]; other site 208964016459 phosphorylation site [posttranslational modification] 208964016460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964016461 ATP binding site [chemical binding]; other site 208964016462 Mg2+ binding site [ion binding]; other site 208964016463 G-X-G motif; other site 208964016464 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 208964016465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964016466 active site 208964016467 phosphorylation site [posttranslational modification] 208964016468 intermolecular recognition site; other site 208964016469 dimerization interface [polypeptide binding]; other site 208964016470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964016471 Walker A motif; other site 208964016472 ATP binding site [chemical binding]; other site 208964016473 Walker B motif; other site 208964016474 arginine finger; other site 208964016475 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964016476 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 208964016477 preprotein translocase subunit SecB; Validated; Region: PRK05751 208964016478 SecA binding site; other site 208964016479 Preprotein binding site; other site 208964016480 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 208964016481 GSH binding site [chemical binding]; other site 208964016482 catalytic residues [active] 208964016483 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 208964016484 active site residue [active] 208964016485 phosphoglyceromutase; Provisional; Region: PRK05434 208964016486 CAAX protease self-immunity; Region: Abi; pfam02517 208964016487 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 208964016488 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 208964016489 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 208964016490 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964016491 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 208964016492 C-terminal peptidase (prc); Region: prc; TIGR00225 208964016493 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 208964016494 protein binding site [polypeptide binding]; other site 208964016495 Catalytic dyad [active] 208964016496 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 208964016497 NodB motif; other site 208964016498 putative active site [active] 208964016499 putative catalytic site [active] 208964016500 Zn binding site [ion binding]; other site 208964016501 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 208964016502 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964016503 substrate binding pocket [chemical binding]; other site 208964016504 membrane-bound complex binding site; other site 208964016505 hinge residues; other site 208964016506 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964016507 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964016508 substrate binding pocket [chemical binding]; other site 208964016509 membrane-bound complex binding site; other site 208964016510 hinge residues; other site 208964016511 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964016512 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964016513 substrate binding pocket [chemical binding]; other site 208964016514 membrane-bound complex binding site; other site 208964016515 hinge residues; other site 208964016516 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 208964016517 substrate binding site [chemical binding]; other site 208964016518 glutamase interaction surface [polypeptide binding]; other site 208964016519 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 208964016520 catalytic residues [active] 208964016521 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 208964016522 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 208964016523 putative active site [active] 208964016524 oxyanion strand; other site 208964016525 catalytic triad [active] 208964016526 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 208964016527 putative active site pocket [active] 208964016528 4-fold oligomerization interface [polypeptide binding]; other site 208964016529 metal binding residues [ion binding]; metal-binding site 208964016530 3-fold/trimer interface [polypeptide binding]; other site 208964016531 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 208964016532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964016533 Coenzyme A binding pocket [chemical binding]; other site 208964016534 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 208964016535 FAD dependent oxidoreductase; Region: DAO; pfam01266 208964016536 AsmA family; Region: AsmA; pfam05170 208964016537 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 208964016538 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 208964016539 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 208964016540 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 208964016541 minor groove reading motif; other site 208964016542 helix-hairpin-helix signature motif; other site 208964016543 substrate binding pocket [chemical binding]; other site 208964016544 active site 208964016545 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 208964016546 DNA binding and oxoG recognition site [nucleotide binding] 208964016547 oxidative damage protection protein; Provisional; Region: PRK05408 208964016548 putative oxidoreductase; Provisional; Region: PRK11579 208964016549 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208964016550 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 208964016551 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208964016552 classical (c) SDRs; Region: SDR_c; cd05233 208964016553 NAD(P) binding site [chemical binding]; other site 208964016554 active site 208964016555 Uncharacterized conserved protein [Function unknown]; Region: COG2928 208964016556 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 208964016557 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208964016558 Walker A/P-loop; other site 208964016559 ATP binding site [chemical binding]; other site 208964016560 Q-loop/lid; other site 208964016561 ABC transporter signature motif; other site 208964016562 Walker B; other site 208964016563 D-loop; other site 208964016564 H-loop/switch region; other site 208964016565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964016566 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208964016567 substrate binding pocket [chemical binding]; other site 208964016568 membrane-bound complex binding site; other site 208964016569 hinge residues; other site 208964016570 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 208964016571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964016572 dimer interface [polypeptide binding]; other site 208964016573 conserved gate region; other site 208964016574 putative PBP binding loops; other site 208964016575 ABC-ATPase subunit interface; other site 208964016576 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 208964016577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964016578 dimer interface [polypeptide binding]; other site 208964016579 conserved gate region; other site 208964016580 putative PBP binding loops; other site 208964016581 ABC-ATPase subunit interface; other site 208964016582 Methyltransferase domain; Region: Methyltransf_32; pfam13679 208964016583 MarR family; Region: MarR_2; cl17246 208964016584 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208964016585 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 208964016586 Outer membrane efflux protein; Region: OEP; pfam02321 208964016587 Outer membrane efflux protein; Region: OEP; pfam02321 208964016588 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 208964016589 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964016590 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 208964016591 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964016592 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 208964016593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964016594 putative substrate translocation pore; other site 208964016595 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 208964016596 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 208964016597 NAD binding site [chemical binding]; other site 208964016598 substrate binding site [chemical binding]; other site 208964016599 homodimer interface [polypeptide binding]; other site 208964016600 active site 208964016601 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 208964016602 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 208964016603 NADP binding site [chemical binding]; other site 208964016604 active site 208964016605 putative substrate binding site [chemical binding]; other site 208964016606 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 208964016607 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 208964016608 substrate binding site; other site 208964016609 tetramer interface; other site 208964016610 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 208964016611 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 208964016612 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 208964016613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964016614 dimer interface [polypeptide binding]; other site 208964016615 phosphorylation site [posttranslational modification] 208964016616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964016617 ATP binding site [chemical binding]; other site 208964016618 Mg2+ binding site [ion binding]; other site 208964016619 G-X-G motif; other site 208964016620 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964016621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964016622 active site 208964016623 phosphorylation site [posttranslational modification] 208964016624 intermolecular recognition site; other site 208964016625 dimerization interface [polypeptide binding]; other site 208964016626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964016627 Walker A motif; other site 208964016628 ATP binding site [chemical binding]; other site 208964016629 Walker B motif; other site 208964016630 arginine finger; other site 208964016631 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 208964016632 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 208964016633 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 208964016634 DctM-like transporters; Region: DctM; pfam06808 208964016635 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 208964016636 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 208964016637 arginine deiminase; Provisional; Region: PRK01388 208964016638 ornithine carbamoyltransferase; Validated; Region: PRK02102 208964016639 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 208964016640 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 208964016641 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 208964016642 putative substrate binding site [chemical binding]; other site 208964016643 nucleotide binding site [chemical binding]; other site 208964016644 nucleotide binding site [chemical binding]; other site 208964016645 homodimer interface [polypeptide binding]; other site 208964016646 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 208964016647 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 208964016648 active site 208964016649 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 208964016650 active site 208964016651 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 208964016652 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 208964016653 dimer interface [polypeptide binding]; other site 208964016654 ADP-ribose binding site [chemical binding]; other site 208964016655 active site 208964016656 nudix motif; other site 208964016657 metal binding site [ion binding]; metal-binding site 208964016658 GMP/IMP nucleotidase; Provisional; Region: PRK14988 208964016659 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 208964016660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964016661 motif II; other site 208964016662 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 208964016663 BON domain; Region: BON; pfam04972 208964016664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208964016665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964016666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964016667 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964016668 dimerization interface [polypeptide binding]; other site 208964016669 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 208964016670 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 208964016671 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 208964016672 putative molybdopterin cofactor binding site [chemical binding]; other site 208964016673 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 208964016674 putative molybdopterin cofactor binding site; other site 208964016675 Global regulator protein family; Region: CsrA; cl00670 208964016676 chorismate mutase; Provisional; Region: PRK09269 208964016677 chorismate mutase, putative; Region: CM_mono2; TIGR01806 208964016678 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208964016679 active site 208964016680 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 208964016681 putative active site [active] 208964016682 metal binding site [ion binding]; metal-binding site 208964016683 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 208964016684 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 208964016685 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208964016686 active site 208964016687 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 208964016688 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 208964016689 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 208964016690 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964016691 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964016692 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 208964016693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964016694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208964016695 dimerization interface [polypeptide binding]; other site 208964016696 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 208964016697 dimer interface [polypeptide binding]; other site 208964016698 FMN binding site [chemical binding]; other site 208964016699 Fimbrial protein; Region: Fimbrial; cl01416 208964016700 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 208964016701 active site 208964016702 substrate-binding site [chemical binding]; other site 208964016703 metal-binding site [ion binding] 208964016704 ATP binding site [chemical binding]; other site 208964016705 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 208964016706 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 208964016707 dimerization interface [polypeptide binding]; other site 208964016708 domain crossover interface; other site 208964016709 redox-dependent activation switch; other site 208964016710 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 208964016711 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 208964016712 active site 208964016713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208964016714 RNA binding surface [nucleotide binding]; other site 208964016715 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 208964016716 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 208964016717 RimK-like ATP-grasp domain; Region: RimK; pfam08443 208964016718 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 208964016719 dimer interface [polypeptide binding]; other site 208964016720 catalytic triad [active] 208964016721 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 208964016722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964016723 dimerization interface [polypeptide binding]; other site 208964016724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964016725 dimer interface [polypeptide binding]; other site 208964016726 phosphorylation site [posttranslational modification] 208964016727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964016728 ATP binding site [chemical binding]; other site 208964016729 Mg2+ binding site [ion binding]; other site 208964016730 G-X-G motif; other site 208964016731 osmolarity response regulator; Provisional; Region: ompR; PRK09468 208964016732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964016733 active site 208964016734 phosphorylation site [posttranslational modification] 208964016735 intermolecular recognition site; other site 208964016736 dimerization interface [polypeptide binding]; other site 208964016737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964016738 DNA binding site [nucleotide binding] 208964016739 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 208964016740 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 208964016741 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 208964016742 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 208964016743 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 208964016744 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 208964016745 RNA binding site [nucleotide binding]; other site 208964016746 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964016747 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 208964016748 CoenzymeA binding site [chemical binding]; other site 208964016749 subunit interaction site [polypeptide binding]; other site 208964016750 PHB binding site; other site 208964016751 glutamate--cysteine ligase; Provisional; Region: PRK02107 208964016752 N-acetylglutamate synthase; Validated; Region: PRK05279 208964016753 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 208964016754 putative feedback inhibition sensing region; other site 208964016755 putative nucleotide binding site [chemical binding]; other site 208964016756 putative substrate binding site [chemical binding]; other site 208964016757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964016758 Coenzyme A binding pocket [chemical binding]; other site 208964016759 inner membrane protein; Provisional; Region: PRK10995 208964016760 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 208964016761 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 208964016762 metal binding site [ion binding]; metal-binding site 208964016763 putative dimer interface [polypeptide binding]; other site 208964016764 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 208964016765 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 208964016766 TIGR00153 family protein; Region: TIGR00153 208964016767 Uncharacterized conserved protein [Function unknown]; Region: COG3025 208964016768 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 208964016769 putative active site [active] 208964016770 putative metal binding residues [ion binding]; other site 208964016771 signature motif; other site 208964016772 putative triphosphate binding site [ion binding]; other site 208964016773 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 208964016774 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 208964016775 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 208964016776 Walker A motif; other site 208964016777 ATP binding site [chemical binding]; other site 208964016778 Walker B motif; other site 208964016779 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 208964016780 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 208964016781 glycine dehydrogenase; Provisional; Region: PRK12566 208964016782 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 208964016783 tetramer interface [polypeptide binding]; other site 208964016784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964016785 catalytic residue [active] 208964016786 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 208964016787 tetramer interface [polypeptide binding]; other site 208964016788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964016789 catalytic residue [active] 208964016790 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 208964016791 lipoyl attachment site [posttranslational modification]; other site 208964016792 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 208964016793 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 208964016794 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 208964016795 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 208964016796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964016797 dimer interface [polypeptide binding]; other site 208964016798 conserved gate region; other site 208964016799 putative PBP binding loops; other site 208964016800 ABC-ATPase subunit interface; other site 208964016801 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 208964016802 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 208964016803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964016804 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 208964016805 dimerization interface [polypeptide binding]; other site 208964016806 substrate binding pocket [chemical binding]; other site 208964016807 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964016808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964016809 putative substrate translocation pore; other site 208964016810 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 208964016811 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 208964016812 Domain of unknown function (DUF4442); Region: DUF4442; pfam14539 208964016813 active site 2 [active] 208964016814 active site 1 [active] 208964016815 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 208964016816 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 208964016817 proline aminopeptidase P II; Provisional; Region: PRK10879 208964016818 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 208964016819 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 208964016820 active site 208964016821 hypothetical protein; Reviewed; Region: PRK02166 208964016822 TIGR02449 family protein; Region: TIGR02449 208964016823 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 208964016824 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 208964016825 Uncharacterized conserved protein [Function unknown]; Region: COG2947 208964016826 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 208964016827 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 208964016828 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 208964016829 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208964016830 Walker A/P-loop; other site 208964016831 ATP binding site [chemical binding]; other site 208964016832 Q-loop/lid; other site 208964016833 ABC transporter signature motif; other site 208964016834 Walker B; other site 208964016835 D-loop; other site 208964016836 H-loop/switch region; other site 208964016837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208964016838 Walker A/P-loop; other site 208964016839 ATP binding site [chemical binding]; other site 208964016840 Q-loop/lid; other site 208964016841 ABC transporter signature motif; other site 208964016842 Walker B; other site 208964016843 D-loop; other site 208964016844 H-loop/switch region; other site 208964016845 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 208964016846 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 208964016847 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 208964016848 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 208964016849 HlyD family secretion protein; Region: HlyD_3; pfam13437 208964016850 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 208964016851 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 208964016852 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 208964016853 NAD(P) binding site [chemical binding]; other site 208964016854 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 208964016855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964016856 putative substrate translocation pore; other site 208964016857 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 208964016858 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964016859 catalytic loop [active] 208964016860 iron binding site [ion binding]; other site 208964016861 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 208964016862 FAD binding pocket [chemical binding]; other site 208964016863 FAD binding motif [chemical binding]; other site 208964016864 phosphate binding motif [ion binding]; other site 208964016865 beta-alpha-beta structure motif; other site 208964016866 NAD binding pocket [chemical binding]; other site 208964016867 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 208964016868 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 208964016869 transcription termination factor Rho; Provisional; Region: rho; PRK09376 208964016870 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 208964016871 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 208964016872 RNA binding site [nucleotide binding]; other site 208964016873 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 208964016874 multimer interface [polypeptide binding]; other site 208964016875 Walker A motif; other site 208964016876 ATP binding site [chemical binding]; other site 208964016877 Walker B motif; other site 208964016878 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 208964016879 catalytic residues [active] 208964016880 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 208964016881 exopolyphosphatase; Region: exo_poly_only; TIGR03706 208964016882 polyphosphate kinase; Provisional; Region: PRK05443 208964016883 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 208964016884 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 208964016885 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 208964016886 putative domain interface [polypeptide binding]; other site 208964016887 putative active site [active] 208964016888 catalytic site [active] 208964016889 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 208964016890 putative domain interface [polypeptide binding]; other site 208964016891 putative active site [active] 208964016892 catalytic site [active] 208964016893 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 208964016894 dimer interface [polypeptide binding]; other site 208964016895 allosteric magnesium binding site [ion binding]; other site 208964016896 active site 208964016897 aspartate-rich active site metal binding site; other site 208964016898 Schiff base residues; other site 208964016899 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 208964016900 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 208964016901 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 208964016902 conserved cys residue [active] 208964016903 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208964016904 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 208964016905 CoenzymeA binding site [chemical binding]; other site 208964016906 subunit interaction site [polypeptide binding]; other site 208964016907 PHB binding site; other site 208964016908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 208964016909 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 208964016910 Cytochrome c; Region: Cytochrom_C; pfam00034 208964016911 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 208964016912 LysE type translocator; Region: LysE; cl00565 208964016913 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 208964016914 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 208964016915 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208964016916 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 208964016917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964016918 ABC transporter; Region: ABC_tran_2; pfam12848 208964016919 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208964016920 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 208964016921 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 208964016922 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 208964016923 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 208964016924 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 208964016925 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 208964016926 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 208964016927 HemY protein N-terminus; Region: HemY_N; pfam07219 208964016928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208964016929 binding surface 208964016930 TPR motif; other site 208964016931 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 208964016932 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 208964016933 active site 208964016934 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 208964016935 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 208964016936 domain interfaces; other site 208964016937 active site 208964016938 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 208964016939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964016940 active site 208964016941 phosphorylation site [posttranslational modification] 208964016942 intermolecular recognition site; other site 208964016943 dimerization interface [polypeptide binding]; other site 208964016944 LytTr DNA-binding domain; Region: LytTR; pfam04397 208964016945 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 208964016946 Histidine kinase; Region: His_kinase; pfam06580 208964016947 argininosuccinate lyase; Provisional; Region: PRK00855 208964016948 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 208964016949 active sites [active] 208964016950 tetramer interface [polypeptide binding]; other site 208964016951 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 208964016952 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 208964016953 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 208964016954 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 208964016955 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 208964016956 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 208964016957 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 208964016958 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 208964016959 Cl binding site [ion binding]; other site 208964016960 oligomer interface [polypeptide binding]; other site 208964016961 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 208964016962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208964016963 substrate binding pocket [chemical binding]; other site 208964016964 membrane-bound complex binding site; other site 208964016965 hinge residues; other site 208964016966 TIGR02647 family protein; Region: DNA 208964016967 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 208964016968 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 208964016969 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 208964016970 Uncharacterized conserved protein [Function unknown]; Region: COG4278 208964016971 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 208964016972 Rnk N-terminus; Region: Rnk_N; pfam14760 208964016973 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 208964016974 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 208964016975 putative iron binding site [ion binding]; other site 208964016976 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 208964016977 diaminopimelate decarboxylase; Region: lysA; TIGR01048 208964016978 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 208964016979 active site 208964016980 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208964016981 substrate binding site [chemical binding]; other site 208964016982 catalytic residues [active] 208964016983 dimer interface [polypeptide binding]; other site 208964016984 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 208964016985 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 208964016986 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 208964016987 Protein of unknown function, DUF484; Region: DUF484; pfam04340 208964016988 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 208964016989 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 208964016990 active site 208964016991 DNA binding site [nucleotide binding] 208964016992 Int/Topo IB signature motif; other site 208964016993 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 208964016994 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 208964016995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208964016996 motif II; other site 208964016997 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 208964016998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964016999 putative substrate translocation pore; other site 208964017000 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 208964017001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964017002 DNA-binding site [nucleotide binding]; DNA binding site 208964017003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964017004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964017005 homodimer interface [polypeptide binding]; other site 208964017006 catalytic residue [active] 208964017007 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 208964017008 Uncharacterized conserved protein [Function unknown]; Region: COG0432 208964017009 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 208964017010 Nitrogen regulatory protein P-II; Region: P-II; cl00412 208964017011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 208964017012 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 208964017013 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 208964017014 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 208964017015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964017016 Walker A motif; other site 208964017017 ATP binding site [chemical binding]; other site 208964017018 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 208964017019 BCCT family transporter; Region: BCCT; cl00569 208964017020 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 208964017021 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 208964017022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964017023 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 208964017024 dimerization interface [polypeptide binding]; other site 208964017025 substrate binding pocket [chemical binding]; other site 208964017026 multidrug efflux protein NorA; Provisional; Region: PRK00187 208964017027 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 208964017028 cation binding site [ion binding]; other site 208964017029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964017030 metal binding site [ion binding]; metal-binding site 208964017031 active site 208964017032 I-site; other site 208964017033 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964017034 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 208964017035 Part of AAA domain; Region: AAA_19; pfam13245 208964017036 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 208964017037 pyruvate dehydrogenase; Provisional; Region: PRK09124 208964017038 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 208964017039 PYR/PP interface [polypeptide binding]; other site 208964017040 dimer interface [polypeptide binding]; other site 208964017041 tetramer interface [polypeptide binding]; other site 208964017042 TPP binding site [chemical binding]; other site 208964017043 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208964017044 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 208964017045 TPP-binding site [chemical binding]; other site 208964017046 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964017047 active site 208964017048 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 208964017049 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 208964017050 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 208964017051 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 208964017052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964017053 non-specific DNA binding site [nucleotide binding]; other site 208964017054 salt bridge; other site 208964017055 sequence-specific DNA binding site [nucleotide binding]; other site 208964017056 Cupin domain; Region: Cupin_2; pfam07883 208964017057 alanine racemase; Reviewed; Region: dadX; PRK03646 208964017058 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 208964017059 active site 208964017060 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208964017061 substrate binding site [chemical binding]; other site 208964017062 catalytic residues [active] 208964017063 dimer interface [polypeptide binding]; other site 208964017064 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 208964017065 homotrimer interaction site [polypeptide binding]; other site 208964017066 putative active site [active] 208964017067 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 208964017068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964017069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964017070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 208964017071 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 208964017072 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 208964017073 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 208964017074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208964017075 putative DNA binding site [nucleotide binding]; other site 208964017076 putative Zn2+ binding site [ion binding]; other site 208964017077 AsnC family; Region: AsnC_trans_reg; pfam01037 208964017078 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 208964017079 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208964017080 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 208964017081 PLD-like domain; Region: PLDc_2; pfam13091 208964017082 putative active site [active] 208964017083 catalytic site [active] 208964017084 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 208964017085 PLD-like domain; Region: PLDc_2; pfam13091 208964017086 putative active site [active] 208964017087 catalytic site [active] 208964017088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964017089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208964017090 putative substrate translocation pore; other site 208964017091 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 208964017092 NAD(P) binding site [chemical binding]; other site 208964017093 catalytic residues [active] 208964017094 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 208964017095 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964017096 inhibitor-cofactor binding pocket; inhibition site 208964017097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964017098 catalytic residue [active] 208964017099 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 208964017100 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 208964017101 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 208964017102 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 208964017103 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 208964017104 peptide binding site [polypeptide binding]; other site 208964017105 hypothetical protein; Reviewed; Region: PRK00024 208964017106 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 208964017107 MPN+ (JAMM) motif; other site 208964017108 Zinc-binding site [ion binding]; other site 208964017109 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 208964017110 Flavoprotein; Region: Flavoprotein; cl19190 208964017111 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 208964017112 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 208964017113 trimer interface [polypeptide binding]; other site 208964017114 active site 208964017115 BCCT family transporter; Region: BCCT; cl00569 208964017116 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 208964017117 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 208964017118 active site 208964017119 substrate binding site [chemical binding]; other site 208964017120 metal binding site [ion binding]; metal-binding site 208964017121 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 208964017122 feedback inhibition sensing region; other site 208964017123 homohexameric interface [polypeptide binding]; other site 208964017124 nucleotide binding site [chemical binding]; other site 208964017125 N-acetyl-L-glutamate binding site [chemical binding]; other site 208964017126 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 208964017127 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964017128 SurA N-terminal domain; Region: SurA_N; pfam09312 208964017129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964017130 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 208964017131 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 208964017132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 208964017133 dimer interface [polypeptide binding]; other site 208964017134 active site 208964017135 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208964017136 substrate binding site [chemical binding]; other site 208964017137 catalytic residue [active] 208964017138 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 208964017139 FAD binding domain; Region: FAD_binding_4; pfam01565 208964017140 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 208964017141 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 208964017142 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208964017143 active site 208964017144 Phage-related minor tail protein [Function unknown]; Region: COG5280 208964017145 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208964017146 active site 208964017147 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 208964017148 putative active site [active] 208964017149 putative catalytic site [active] 208964017150 putative DNA binding site [nucleotide binding]; other site 208964017151 putative phosphate binding site [ion binding]; other site 208964017152 metal binding site A [ion binding]; metal-binding site 208964017153 putative AP binding site [nucleotide binding]; other site 208964017154 putative metal binding site B [ion binding]; other site 208964017155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 208964017156 ribonuclease PH; Reviewed; Region: rph; PRK00173 208964017157 Ribonuclease PH; Region: RNase_PH_bact; cd11362 208964017158 hexamer interface [polypeptide binding]; other site 208964017159 active site 208964017160 hypothetical protein; Provisional; Region: PRK11820 208964017161 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 208964017162 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 208964017163 Guanylate kinase; Region: Guanylate_kin; pfam00625 208964017164 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 208964017165 catalytic site [active] 208964017166 G-X2-G-X-G-K; other site 208964017167 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 208964017168 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 208964017169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208964017170 Zn2+ binding site [ion binding]; other site 208964017171 Mg2+ binding site [ion binding]; other site 208964017172 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 208964017173 synthetase active site [active] 208964017174 NTP binding site [chemical binding]; other site 208964017175 metal binding site [ion binding]; metal-binding site 208964017176 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 208964017177 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 208964017178 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 208964017179 homotrimer interaction site [polypeptide binding]; other site 208964017180 putative active site [active] 208964017181 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 208964017182 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208964017183 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208964017184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964017185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964017186 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208964017187 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 208964017188 putative NAD(P) binding site [chemical binding]; other site 208964017189 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 208964017190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964017191 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 208964017192 dimerization interface [polypeptide binding]; other site 208964017193 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 208964017194 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 208964017195 generic binding surface II; other site 208964017196 ssDNA binding site; other site 208964017197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208964017198 ATP binding site [chemical binding]; other site 208964017199 putative Mg++ binding site [ion binding]; other site 208964017200 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208964017201 nucleotide binding region [chemical binding]; other site 208964017202 ATP-binding site [chemical binding]; other site 208964017203 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 208964017204 putative deacylase active site [active] 208964017205 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 208964017206 HDOD domain; Region: HDOD; pfam08668 208964017207 histone-like DNA-binding protein HU; Region: HU; cd13831 208964017208 dimer interface [polypeptide binding]; other site 208964017209 DNA binding site [nucleotide binding] 208964017210 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 208964017211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208964017212 hypothetical protein; Provisional; Region: PRK07236 208964017213 Rubredoxin [Energy production and conversion]; Region: COG1773 208964017214 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 208964017215 iron binding site [ion binding]; other site 208964017216 Rubredoxin [Energy production and conversion]; Region: COG1773 208964017217 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 208964017218 iron binding site [ion binding]; other site 208964017219 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 208964017220 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 208964017221 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 208964017222 Cysteine-rich domain; Region: CCG; pfam02754 208964017223 Cysteine-rich domain; Region: CCG; pfam02754 208964017224 FAD binding domain; Region: FAD_binding_4; pfam01565 208964017225 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 208964017226 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 208964017227 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 208964017228 FAD binding domain; Region: FAD_binding_4; pfam01565 208964017229 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 208964017230 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 208964017231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964017232 DNA-binding site [nucleotide binding]; DNA binding site 208964017233 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 208964017234 Chorismate lyase; Region: Chor_lyase; pfam04345 208964017235 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 208964017236 putative active site [active] 208964017237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 208964017238 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 208964017239 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 208964017240 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 208964017241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964017242 active site 208964017243 phosphorylation site [posttranslational modification] 208964017244 intermolecular recognition site; other site 208964017245 dimerization interface [polypeptide binding]; other site 208964017246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208964017247 DNA binding site [nucleotide binding] 208964017248 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 208964017249 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 208964017250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964017251 putative active site [active] 208964017252 heme pocket [chemical binding]; other site 208964017253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964017254 dimer interface [polypeptide binding]; other site 208964017255 phosphorylation site [posttranslational modification] 208964017256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964017257 ATP binding site [chemical binding]; other site 208964017258 Mg2+ binding site [ion binding]; other site 208964017259 G-X-G motif; other site 208964017260 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 208964017261 Domain of unknown function DUF21; Region: DUF21; pfam01595 208964017262 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 208964017263 Transporter associated domain; Region: CorC_HlyC; pfam03471 208964017264 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 208964017265 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208964017266 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964017267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964017268 active site 208964017269 phosphorylation site [posttranslational modification] 208964017270 intermolecular recognition site; other site 208964017271 dimerization interface [polypeptide binding]; other site 208964017272 transcriptional regulator PhoU; Provisional; Region: PRK11115 208964017273 PhoU domain; Region: PhoU; pfam01895 208964017274 PhoU domain; Region: PhoU; pfam01895 208964017275 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 208964017276 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 208964017277 Walker A/P-loop; other site 208964017278 ATP binding site [chemical binding]; other site 208964017279 Q-loop/lid; other site 208964017280 ABC transporter signature motif; other site 208964017281 Walker B; other site 208964017282 D-loop; other site 208964017283 H-loop/switch region; other site 208964017284 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 208964017285 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 208964017286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964017287 dimer interface [polypeptide binding]; other site 208964017288 conserved gate region; other site 208964017289 putative PBP binding loops; other site 208964017290 ABC-ATPase subunit interface; other site 208964017291 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 208964017292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964017293 ABC-ATPase subunit interface; other site 208964017294 phosphate binding protein; Region: ptsS_2; TIGR02136 208964017295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964017296 metabolite-proton symporter; Region: 2A0106; TIGR00883 208964017297 putative substrate translocation pore; other site 208964017298 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 208964017299 choline dehydrogenase; Validated; Region: PRK02106 208964017300 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 208964017301 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 208964017302 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 208964017303 tetrameric interface [polypeptide binding]; other site 208964017304 NAD binding site [chemical binding]; other site 208964017305 catalytic residues [active] 208964017306 transcriptional regulator BetI; Validated; Region: PRK00767 208964017307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208964017308 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 208964017309 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 208964017310 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 208964017311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208964017312 Walker A/P-loop; other site 208964017313 ATP binding site [chemical binding]; other site 208964017314 Q-loop/lid; other site 208964017315 ABC transporter signature motif; other site 208964017316 Walker B; other site 208964017317 D-loop; other site 208964017318 H-loop/switch region; other site 208964017319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964017320 dimer interface [polypeptide binding]; other site 208964017321 conserved gate region; other site 208964017322 putative PBP binding loops; other site 208964017323 ABC-ATPase subunit interface; other site 208964017324 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 208964017325 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 208964017326 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 208964017327 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 208964017328 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 208964017329 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 208964017330 conserved cys residue [active] 208964017331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964017332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964017333 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 208964017334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964017335 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 208964017336 putative dimerization interface [polypeptide binding]; other site 208964017337 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 208964017338 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964017339 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 208964017340 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208964017341 active site 208964017342 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 208964017343 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 208964017344 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208964017345 Uncharacterized conserved protein [Function unknown]; Region: COG3246 208964017346 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 208964017347 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 208964017348 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 208964017349 conserved cys residue [active] 208964017350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208964017351 acetylornithine deacetylase; Provisional; Region: PRK07522 208964017352 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 208964017353 metal binding site [ion binding]; metal-binding site 208964017354 putative dimer interface [polypeptide binding]; other site 208964017355 Uncharacterized conserved protein [Function unknown]; Region: COG3342 208964017356 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 208964017357 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 208964017358 homotrimer interaction site [polypeptide binding]; other site 208964017359 putative active site [active] 208964017360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 208964017361 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 208964017362 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 208964017363 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 208964017364 putative active site [active] 208964017365 catalytic site [active] 208964017366 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 208964017367 putative active site [active] 208964017368 catalytic site [active] 208964017369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 208964017370 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 208964017371 active site 208964017372 V4R domain; Region: V4R; cl15268 208964017373 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 208964017374 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 208964017375 putative active site [active] 208964017376 putative FMN binding site [chemical binding]; other site 208964017377 putative substrate binding site [chemical binding]; other site 208964017378 putative catalytic residue [active] 208964017379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208964017380 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 208964017381 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 208964017382 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 208964017383 Cysteine-rich domain; Region: CCG; pfam02754 208964017384 Cysteine-rich domain; Region: CCG; pfam02754 208964017385 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 208964017386 Electron transfer flavoprotein domain; Region: ETF; pfam01012 208964017387 Ligand Binding Site [chemical binding]; other site 208964017388 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 208964017389 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 208964017390 Ligand Binding Site [chemical binding]; other site 208964017391 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208964017392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208964017393 non-specific DNA binding site [nucleotide binding]; other site 208964017394 salt bridge; other site 208964017395 sequence-specific DNA binding site [nucleotide binding]; other site 208964017396 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 208964017397 Cell division protein ZapA; Region: ZapA; pfam05164 208964017398 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 208964017399 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 208964017400 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 208964017401 [2Fe-2S] cluster binding site [ion binding]; other site 208964017402 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 208964017403 putative alpha subunit interface [polypeptide binding]; other site 208964017404 putative active site [active] 208964017405 putative substrate binding site [chemical binding]; other site 208964017406 Fe binding site [ion binding]; other site 208964017407 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 208964017408 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 208964017409 FAD binding pocket [chemical binding]; other site 208964017410 FAD binding motif [chemical binding]; other site 208964017411 phosphate binding motif [ion binding]; other site 208964017412 beta-alpha-beta structure motif; other site 208964017413 NAD binding pocket [chemical binding]; other site 208964017414 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 208964017415 catalytic loop [active] 208964017416 iron binding site [ion binding]; other site 208964017417 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 208964017418 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 208964017419 tetramer interface [polypeptide binding]; other site 208964017420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964017421 catalytic residue [active] 208964017422 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 208964017423 dimer interface [polypeptide binding]; other site 208964017424 active site 208964017425 glycine-pyridoxal phosphate binding site [chemical binding]; other site 208964017426 folate binding site [chemical binding]; other site 208964017427 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 208964017428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 208964017429 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 208964017430 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 208964017431 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 208964017432 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 208964017433 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 208964017434 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 208964017435 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 208964017436 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 208964017437 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 208964017438 putative active site [active] 208964017439 putative substrate binding site [chemical binding]; other site 208964017440 putative cosubstrate binding site; other site 208964017441 catalytic site [active] 208964017442 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 208964017443 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 208964017444 NAD binding site [chemical binding]; other site 208964017445 catalytic Zn binding site [ion binding]; other site 208964017446 structural Zn binding site [ion binding]; other site 208964017447 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 208964017448 active site 208964017449 phosphate binding residues; other site 208964017450 catalytic residues [active] 208964017451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3495 208964017452 Predicted membrane protein [Function unknown]; Region: COG2261 208964017453 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 208964017454 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 208964017455 NAD binding site [chemical binding]; other site 208964017456 ATP-grasp domain; Region: ATP-grasp; pfam02222 208964017457 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 208964017458 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 208964017459 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 208964017460 NAD binding site [chemical binding]; other site 208964017461 substrate binding site [chemical binding]; other site 208964017462 catalytic Zn binding site [ion binding]; other site 208964017463 tetramer interface [polypeptide binding]; other site 208964017464 structural Zn binding site [ion binding]; other site 208964017465 cell density-dependent motility repressor; Provisional; Region: PRK10082 208964017466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964017467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208964017468 dimerization interface [polypeptide binding]; other site 208964017469 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 208964017470 Aspartase; Region: Aspartase; cd01357 208964017471 active sites [active] 208964017472 tetramer interface [polypeptide binding]; other site 208964017473 Sulphur transport; Region: Sulf_transp; cl19477 208964017474 Predicted transporter component [General function prediction only]; Region: COG2391 208964017475 Sulphur transport; Region: Sulf_transp; cl19477 208964017476 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 208964017477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964017478 DNA-binding site [nucleotide binding]; DNA binding site 208964017479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208964017480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964017481 homodimer interface [polypeptide binding]; other site 208964017482 catalytic residue [active] 208964017483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208964017484 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208964017485 Coenzyme A binding pocket [chemical binding]; other site 208964017486 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 208964017487 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208964017488 tryptophan permease; Provisional; Region: PRK10483 208964017489 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 208964017490 pyruvate carboxylase subunit B; Validated; Region: PRK09282 208964017491 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 208964017492 active site 208964017493 catalytic residues [active] 208964017494 metal binding site [ion binding]; metal-binding site 208964017495 homodimer binding site [polypeptide binding]; other site 208964017496 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 208964017497 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208964017498 carboxyltransferase (CT) interaction site; other site 208964017499 biotinylation site [posttranslational modification]; other site 208964017500 pyruvate carboxylase subunit A; Validated; Region: PRK07178 208964017501 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208964017502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208964017503 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 208964017504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208964017505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208964017506 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 208964017507 putative dimerization interface [polypeptide binding]; other site 208964017508 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 208964017509 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208964017510 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208964017511 putative active site [active] 208964017512 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 208964017513 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 208964017514 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 208964017515 putative protease; Provisional; Region: PRK15452 208964017516 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 208964017517 PAS fold; Region: PAS_3; pfam08447 208964017518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964017519 heme pocket [chemical binding]; other site 208964017520 putative active site [active] 208964017521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964017522 PAS domain; Region: PAS_9; pfam13426 208964017523 putative active site [active] 208964017524 heme pocket [chemical binding]; other site 208964017525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964017526 metal binding site [ion binding]; metal-binding site 208964017527 active site 208964017528 I-site; other site 208964017529 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 208964017530 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 208964017531 Part of AAA domain; Region: AAA_19; pfam13245 208964017532 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 208964017533 Predicted membrane protein [Function unknown]; Region: COG2510 208964017534 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 208964017535 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 208964017536 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 208964017537 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 208964017538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964017539 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 208964017540 putative ADP-binding pocket [chemical binding]; other site 208964017541 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964017542 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 208964017543 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 208964017544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964017545 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 208964017546 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 208964017547 Walker A/P-loop; other site 208964017548 ATP binding site [chemical binding]; other site 208964017549 Q-loop/lid; other site 208964017550 ABC transporter signature motif; other site 208964017551 Walker B; other site 208964017552 D-loop; other site 208964017553 H-loop/switch region; other site 208964017554 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 208964017555 putative carbohydrate binding site [chemical binding]; other site 208964017556 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 208964017557 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 208964017558 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 208964017559 Substrate binding site; other site 208964017560 Cupin domain; Region: Cupin_2; cl17218 208964017561 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 208964017562 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 208964017563 NADP-binding site; other site 208964017564 homotetramer interface [polypeptide binding]; other site 208964017565 substrate binding site [chemical binding]; other site 208964017566 homodimer interface [polypeptide binding]; other site 208964017567 active site 208964017568 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208964017569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964017570 NAD(P) binding site [chemical binding]; other site 208964017571 active site 208964017572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964017573 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208964017574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208964017575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208964017576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 208964017577 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964017578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964017579 S-adenosylmethionine binding site [chemical binding]; other site 208964017580 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 208964017581 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208964017582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964017583 S-adenosylmethionine binding site [chemical binding]; other site 208964017584 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 208964017585 conserverd hypothetical protein; Region: TIGR02448 208964017586 conserverd hypothetical protein; Region: TIGR02448 208964017587 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 208964017588 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 208964017589 Uncharacterized conserved protein [Function unknown]; Region: COG3791 208964017590 Predicted permeases [General function prediction only]; Region: COG0679 208964017591 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 208964017592 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 208964017593 Citrate transporter; Region: CitMHS; pfam03600 208964017594 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 208964017595 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 208964017596 RF-1 domain; Region: RF-1; cl17422 208964017597 hypothetical protein; Reviewed; Region: PRK09588 208964017598 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 208964017599 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 208964017600 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 208964017601 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 208964017602 PhoU domain; Region: PhoU; pfam01895 208964017603 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 208964017604 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 208964017605 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 208964017606 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208964017607 citrate-proton symporter; Provisional; Region: PRK15075 208964017608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964017609 putative substrate translocation pore; other site 208964017610 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 208964017611 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 208964017612 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 208964017613 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 208964017614 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 208964017615 hypothetical protein; Provisional; Region: PRK13682 208964017616 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964017617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964017618 active site 208964017619 phosphorylation site [posttranslational modification] 208964017620 intermolecular recognition site; other site 208964017621 dimerization interface [polypeptide binding]; other site 208964017622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964017623 Walker A motif; other site 208964017624 ATP binding site [chemical binding]; other site 208964017625 Walker B motif; other site 208964017626 arginine finger; other site 208964017627 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 208964017628 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208964017629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208964017630 dimerization interface [polypeptide binding]; other site 208964017631 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 208964017632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208964017633 putative active site [active] 208964017634 heme pocket [chemical binding]; other site 208964017635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964017636 dimer interface [polypeptide binding]; other site 208964017637 phosphorylation site [posttranslational modification] 208964017638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964017639 ATP binding site [chemical binding]; other site 208964017640 Mg2+ binding site [ion binding]; other site 208964017641 G-X-G motif; other site 208964017642 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 208964017643 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 208964017644 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 208964017645 amidase catalytic site [active] 208964017646 Zn binding residues [ion binding]; other site 208964017647 substrate binding site [chemical binding]; other site 208964017648 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 208964017649 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 208964017650 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208964017651 metal binding site [ion binding]; metal-binding site 208964017652 active site 208964017653 I-site; other site 208964017654 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 208964017655 putative catalytic site [active] 208964017656 putative phosphate binding site [ion binding]; other site 208964017657 putative metal binding site [ion binding]; other site 208964017658 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 208964017659 catalytic residues [active] 208964017660 hinge region; other site 208964017661 alpha helical domain; other site 208964017662 Cytochrome c553 [Energy production and conversion]; Region: COG2863 208964017663 Cytochrome c; Region: Cytochrom_C; cl11414 208964017664 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 208964017665 Predicted GTPase [General function prediction only]; Region: COG0218 208964017666 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 208964017667 G1 box; other site 208964017668 GTP/Mg2+ binding site [chemical binding]; other site 208964017669 Switch I region; other site 208964017670 G2 box; other site 208964017671 G3 box; other site 208964017672 Switch II region; other site 208964017673 G4 box; other site 208964017674 G5 box; other site 208964017675 DNA polymerase I; Provisional; Region: PRK05755 208964017676 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 208964017677 active site 208964017678 metal binding site 1 [ion binding]; metal-binding site 208964017679 putative 5' ssDNA interaction site; other site 208964017680 metal binding site 3; metal-binding site 208964017681 metal binding site 2 [ion binding]; metal-binding site 208964017682 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 208964017683 putative DNA binding site [nucleotide binding]; other site 208964017684 putative metal binding site [ion binding]; other site 208964017685 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 208964017686 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 208964017687 active site 208964017688 catalytic site [active] 208964017689 substrate binding site [chemical binding]; other site 208964017690 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 208964017691 active site 208964017692 DNA binding site [nucleotide binding] 208964017693 catalytic site [active] 208964017694 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 208964017695 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 208964017696 Phosphotransferase enzyme family; Region: APH; pfam01636 208964017697 putative active site [active] 208964017698 putative substrate binding site [chemical binding]; other site 208964017699 ATP binding site [chemical binding]; other site 208964017700 Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209 208964017701 TSCPD domain; Region: TSCPD; pfam12637 208964017702 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 208964017703 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 208964017704 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 208964017705 active site 208964017706 dimer interface [polypeptide binding]; other site 208964017707 effector binding site; other site 208964017708 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 208964017709 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 208964017710 metal binding site [ion binding]; metal-binding site 208964017711 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 208964017712 metal binding site 2 [ion binding]; metal-binding site 208964017713 putative DNA binding helix; other site 208964017714 metal binding site 1 [ion binding]; metal-binding site 208964017715 dimer interface [polypeptide binding]; other site 208964017716 structural Zn2+ binding site [ion binding]; other site 208964017717 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 208964017718 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 208964017719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208964017720 ABC-ATPase subunit interface; other site 208964017721 dimer interface [polypeptide binding]; other site 208964017722 putative PBP binding regions; other site 208964017723 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 208964017724 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 208964017725 Walker A/P-loop; other site 208964017726 ATP binding site [chemical binding]; other site 208964017727 Q-loop/lid; other site 208964017728 ABC transporter signature motif; other site 208964017729 Walker B; other site 208964017730 D-loop; other site 208964017731 H-loop/switch region; other site 208964017732 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 208964017733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208964017734 dimer interface [polypeptide binding]; other site 208964017735 conserved gate region; other site 208964017736 putative PBP binding loops; other site 208964017737 ABC-ATPase subunit interface; other site 208964017738 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 208964017739 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 208964017740 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208964017741 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208964017742 putative active site [active] 208964017743 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 208964017744 catalytic triad [active] 208964017745 conserved cis-peptide bond; other site 208964017746 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208964017747 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208964017748 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 208964017749 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208964017750 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 208964017751 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 208964017752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208964017753 active site 208964017754 phosphorylation site [posttranslational modification] 208964017755 intermolecular recognition site; other site 208964017756 dimerization interface [polypeptide binding]; other site 208964017757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208964017758 Walker A motif; other site 208964017759 ATP binding site [chemical binding]; other site 208964017760 Walker B motif; other site 208964017761 arginine finger; other site 208964017762 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 208964017763 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 208964017764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208964017765 dimer interface [polypeptide binding]; other site 208964017766 phosphorylation site [posttranslational modification] 208964017767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208964017768 ATP binding site [chemical binding]; other site 208964017769 Mg2+ binding site [ion binding]; other site 208964017770 G-X-G motif; other site 208964017771 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208964017772 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 208964017773 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 208964017774 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 208964017775 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 208964017776 pyridoxal binding site [chemical binding]; other site 208964017777 dimer interface [polypeptide binding]; other site 208964017778 ATP binding site [chemical binding]; other site 208964017779 Predicted membrane protein [Function unknown]; Region: COG1238 208964017780 putative cation:proton antiport protein; Provisional; Region: PRK10669 208964017781 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 208964017782 TrkA-N domain; Region: TrkA_N; pfam02254 208964017783 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 208964017784 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208964017785 classical (c) SDRs; Region: SDR_c; cd05233 208964017786 NAD(P) binding site [chemical binding]; other site 208964017787 active site 208964017788 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208964017789 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208964017790 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 208964017791 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208964017792 inhibitor-cofactor binding pocket; inhibition site 208964017793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208964017794 catalytic residue [active] 208964017795 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208964017796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208964017797 NAD(P) binding site [chemical binding]; other site 208964017798 active site 208964017799 Transcriptional regulators [Transcription]; Region: GntR; COG1802 208964017800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208964017801 DNA-binding site [nucleotide binding]; DNA binding site 208964017802 FCD domain; Region: FCD; pfam07729 208964017803 Protein of unknown function (DUF3157); Region: DUF3157; pfam11355 208964017804 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 208964017805 SMI1-KNR4 cell-wall; Region: SUKH_5; pfam14567 208964017806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 208964017807 Tim44-like domain; Region: Tim44; pfam04280 208964017808 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 208964017809 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 208964017810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964017811 putative substrate translocation pore; other site 208964017812 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 208964017813 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 208964017814 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 208964017815 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 208964017816 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 208964017817 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 208964017818 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 208964017819 AMIN domain; Region: AMIN; pfam11741 208964017820 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 208964017821 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 208964017822 active site 208964017823 metal binding site [ion binding]; metal-binding site 208964017824 putative GTP cyclohydrolase; Provisional; Region: PRK13674 208964017825 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 208964017826 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 208964017827 trimer interface [polypeptide binding]; other site 208964017828 active site 208964017829 dihydroorotase; Reviewed; Region: PRK09236 208964017830 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 208964017831 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 208964017832 active site 208964017833 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 208964017834 Uncharacterized conserved protein [Function unknown]; Region: COG4729 208964017835 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 208964017836 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 208964017837 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 208964017838 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 208964017839 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 208964017840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208964017841 S-adenosylmethionine binding site [chemical binding]; other site 208964017842 Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488 208964017843 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 208964017844 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 208964017845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208964017846 putative substrate translocation pore; other site 208964017847 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 208964017848 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 208964017849 glutaminase active site [active] 208964017850 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 208964017851 dimer interface [polypeptide binding]; other site 208964017852 active site 208964017853 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 208964017854 dimer interface [polypeptide binding]; other site 208964017855 active site 208964017856 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 208964017857 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 208964017858 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 208964017859 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208964017860 Peptidase family M23; Region: Peptidase_M23; pfam01551 208964017861 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 208964017862 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 208964017863 Substrate binding site; other site 208964017864 Mg++ binding site; other site 208964017865 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 208964017866 active site 208964017867 substrate binding site [chemical binding]; other site 208964017868 CoA binding site [chemical binding]; other site 208964017869 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 208964017870 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 208964017871 gamma subunit interface [polypeptide binding]; other site 208964017872 epsilon subunit interface [polypeptide binding]; other site 208964017873 LBP interface [polypeptide binding]; other site 208964017874 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 208964017875 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 208964017876 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 208964017877 alpha subunit interaction interface [polypeptide binding]; other site 208964017878 Walker A motif; other site 208964017879 ATP binding site [chemical binding]; other site 208964017880 Walker B motif; other site 208964017881 inhibitor binding site; inhibition site 208964017882 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 208964017883 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 208964017884 core domain interface [polypeptide binding]; other site 208964017885 delta subunit interface [polypeptide binding]; other site 208964017886 epsilon subunit interface [polypeptide binding]; other site 208964017887 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 208964017888 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 208964017889 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 208964017890 beta subunit interaction interface [polypeptide binding]; other site 208964017891 Walker A motif; other site 208964017892 ATP binding site [chemical binding]; other site 208964017893 Walker B motif; other site 208964017894 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 208964017895 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 208964017896 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 208964017897 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 208964017898 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 208964017899 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 208964017900 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 208964017901 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 208964017902 ParB-like nuclease domain; Region: ParBc; pfam02195 208964017903 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 208964017904 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 208964017905 P-loop; other site 208964017906 Magnesium ion binding site [ion binding]; other site 208964017907 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 208964017908 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 208964017909 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 208964017910 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 208964017911 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 208964017912 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 208964017913 trmE is a tRNA modification GTPase; Region: trmE; cd04164 208964017914 G1 box; other site 208964017915 GTP/Mg2+ binding site [chemical binding]; other site 208964017916 Switch I region; other site 208964017917 G2 box; other site 208964017918 Switch II region; other site 208964017919 G3 box; other site 208964017920 G4 box; other site 208964017921 G5 box; other site 208964017922 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 208964017923 membrane protein insertase; Provisional; Region: PRK01318 208964017924 YidC periplasmic domain; Region: YidC_periplas; pfam14849 208964017925 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 208964017926 ribonuclease P; Reviewed; Region: rnpA; PRK00396 208964017927 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468