-- dump date 20140620_004825 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1294143000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1294143000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1294143000004 Walker A motif; other site 1294143000005 ATP binding site [chemical binding]; other site 1294143000006 Walker B motif; other site 1294143000007 arginine finger; other site 1294143000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1294143000009 DnaA box-binding interface [nucleotide binding]; other site 1294143000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1294143000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1294143000012 putative DNA binding surface [nucleotide binding]; other site 1294143000013 dimer interface [polypeptide binding]; other site 1294143000014 beta-clamp/clamp loader binding surface; other site 1294143000015 beta-clamp/translesion DNA polymerase binding surface; other site 1294143000016 recombination protein F; Reviewed; Region: recF; PRK00064 1294143000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143000018 Walker A/P-loop; other site 1294143000019 ATP binding site [chemical binding]; other site 1294143000020 Q-loop/lid; other site 1294143000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143000022 ABC transporter signature motif; other site 1294143000023 Walker B; other site 1294143000024 D-loop; other site 1294143000025 H-loop/switch region; other site 1294143000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1294143000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143000028 Mg2+ binding site [ion binding]; other site 1294143000029 G-X-G motif; other site 1294143000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1294143000031 anchoring element; other site 1294143000032 dimer interface [polypeptide binding]; other site 1294143000033 ATP binding site [chemical binding]; other site 1294143000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1294143000035 active site 1294143000036 putative metal-binding site [ion binding]; other site 1294143000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1294143000038 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1294143000039 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1294143000040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143000041 ATP binding site [chemical binding]; other site 1294143000042 putative Mg++ binding site [ion binding]; other site 1294143000043 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1294143000044 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1294143000045 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1294143000046 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1294143000047 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1294143000048 Protein of unknown function DUF262; Region: DUF262; pfam03235 1294143000049 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1294143000050 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1294143000051 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1294143000052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143000053 ATP binding site [chemical binding]; other site 1294143000054 putative Mg++ binding site [ion binding]; other site 1294143000055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143000056 nucleotide binding region [chemical binding]; other site 1294143000057 ATP-binding site [chemical binding]; other site 1294143000058 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1294143000059 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1294143000060 HSP70 interaction site [polypeptide binding]; other site 1294143000061 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1294143000062 Integrase core domain; Region: rve; pfam00665 1294143000063 AAA ATPase domain; Region: AAA_16; pfam13191 1294143000064 AAA domain; Region: AAA_22; pfam13401 1294143000065 TniQ; Region: TniQ; pfam06527 1294143000066 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1294143000067 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1294143000068 putative active site [active] 1294143000069 putative metal binding site [ion binding]; other site 1294143000070 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1294143000071 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1294143000072 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1294143000073 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1294143000074 putative active site [active] 1294143000075 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1294143000076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143000077 non-specific DNA binding site [nucleotide binding]; other site 1294143000078 salt bridge; other site 1294143000079 sequence-specific DNA binding site [nucleotide binding]; other site 1294143000080 Domain of unknown function (DUF955); Region: DUF955; cl01076 1294143000081 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1294143000082 Competence protein CoiA-like family; Region: CoiA; cl11541 1294143000083 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1294143000084 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1294143000085 putative acyl-acceptor binding pocket; other site 1294143000086 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1294143000087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143000088 active site 1294143000089 motif I; other site 1294143000090 motif II; other site 1294143000091 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1294143000092 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1294143000093 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1294143000094 dimer interface [polypeptide binding]; other site 1294143000095 motif 1; other site 1294143000096 active site 1294143000097 motif 2; other site 1294143000098 motif 3; other site 1294143000099 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1294143000100 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1294143000101 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1294143000102 putative acyl-acceptor binding pocket; other site 1294143000103 manganese transport protein MntH; Reviewed; Region: PRK00701 1294143000104 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1294143000105 PilZ domain; Region: PilZ; pfam07238 1294143000106 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1294143000107 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143000108 Walker A/P-loop; other site 1294143000109 ATP binding site [chemical binding]; other site 1294143000110 Q-loop/lid; other site 1294143000111 ABC transporter signature motif; other site 1294143000112 Walker B; other site 1294143000113 D-loop; other site 1294143000114 H-loop/switch region; other site 1294143000115 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143000116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143000117 dimer interface [polypeptide binding]; other site 1294143000118 conserved gate region; other site 1294143000119 putative PBP binding loops; other site 1294143000120 ABC-ATPase subunit interface; other site 1294143000121 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143000122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143000123 dimer interface [polypeptide binding]; other site 1294143000124 conserved gate region; other site 1294143000125 putative PBP binding loops; other site 1294143000126 ABC-ATPase subunit interface; other site 1294143000127 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1294143000128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143000129 substrate binding pocket [chemical binding]; other site 1294143000130 membrane-bound complex binding site; other site 1294143000131 hinge residues; other site 1294143000132 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143000133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143000134 DNA-binding site [nucleotide binding]; DNA binding site 1294143000135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143000136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143000137 homodimer interface [polypeptide binding]; other site 1294143000138 catalytic residue [active] 1294143000139 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1294143000140 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1294143000141 tetramer interface [polypeptide binding]; other site 1294143000142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143000143 catalytic residue [active] 1294143000144 ectoine utilization protein EutC; Validated; Region: PRK08291 1294143000145 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1294143000146 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 1294143000147 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1294143000148 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1294143000149 active site 1294143000150 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 1294143000151 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 1294143000152 putative active site [active] 1294143000153 Zn binding site [ion binding]; other site 1294143000154 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143000155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143000156 putative DNA binding site [nucleotide binding]; other site 1294143000157 putative Zn2+ binding site [ion binding]; other site 1294143000158 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143000159 hypothetical protein; Provisional; Region: PRK11212 1294143000160 succinic semialdehyde dehydrogenase; Region: PLN02278 1294143000161 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1294143000162 tetramerization interface [polypeptide binding]; other site 1294143000163 NAD(P) binding site [chemical binding]; other site 1294143000164 catalytic residues [active] 1294143000165 hypothetical protein; Provisional; Region: PRK07482 1294143000166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143000167 inhibitor-cofactor binding pocket; inhibition site 1294143000168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143000169 catalytic residue [active] 1294143000170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143000171 TPR motif; other site 1294143000172 binding surface 1294143000173 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1294143000174 TrkA-N domain; Region: TrkA_N; pfam02254 1294143000175 TrkA-C domain; Region: TrkA_C; pfam02080 1294143000176 TrkA-N domain; Region: TrkA_N; pfam02254 1294143000177 TrkA-C domain; Region: TrkA_C; pfam02080 1294143000178 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1294143000179 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1294143000180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143000181 S-adenosylmethionine binding site [chemical binding]; other site 1294143000182 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1294143000183 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1294143000184 putative active site [active] 1294143000185 substrate binding site [chemical binding]; other site 1294143000186 putative cosubstrate binding site; other site 1294143000187 catalytic site [active] 1294143000188 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1294143000189 substrate binding site [chemical binding]; other site 1294143000190 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1294143000191 active site 1294143000192 catalytic residues [active] 1294143000193 metal binding site [ion binding]; metal-binding site 1294143000194 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1294143000195 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143000196 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1294143000197 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1294143000198 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1294143000199 DNA protecting protein DprA; Region: dprA; TIGR00732 1294143000200 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1294143000201 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1294143000202 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1294143000203 NADP binding site [chemical binding]; other site 1294143000204 dimer interface [polypeptide binding]; other site 1294143000205 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1294143000206 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1294143000207 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1294143000208 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1294143000209 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1294143000210 shikimate binding site; other site 1294143000211 NAD(P) binding site [chemical binding]; other site 1294143000212 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1294143000213 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1294143000214 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1294143000215 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1294143000216 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1294143000217 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1294143000218 Sulfatase; Region: Sulfatase; cl17466 1294143000219 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1294143000220 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1294143000221 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1294143000222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143000223 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1294143000224 dimerization interface [polypeptide binding]; other site 1294143000225 substrate binding pocket [chemical binding]; other site 1294143000226 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1294143000227 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143000228 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1294143000229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143000230 DNA binding residues [nucleotide binding] 1294143000231 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1294143000232 FecR protein; Region: FecR; pfam04773 1294143000233 Secretin and TonB N terminus short domain; Region: STN; smart00965 1294143000234 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1294143000235 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143000236 N-terminal plug; other site 1294143000237 ligand-binding site [chemical binding]; other site 1294143000238 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1294143000239 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1294143000240 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143000241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143000242 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1294143000243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143000244 putative metal binding site [ion binding]; other site 1294143000245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1294143000246 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1294143000247 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1294143000248 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1294143000249 substrate binding site [chemical binding]; other site 1294143000250 active site 1294143000251 catalytic residues [active] 1294143000252 heterodimer interface [polypeptide binding]; other site 1294143000253 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1294143000254 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1294143000255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143000256 catalytic residue [active] 1294143000257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143000258 D-serine deaminase transcriptional activator; Region: dsdC; TIGR02036 1294143000259 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143000260 dimerization interface [polypeptide binding]; other site 1294143000261 Dodecin; Region: Dodecin; pfam07311 1294143000262 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1294143000263 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1294143000264 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 1294143000265 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1294143000266 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143000267 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143000268 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143000269 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1294143000270 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1294143000271 acyl-activating enzyme (AAE) consensus motif; other site 1294143000272 putative AMP binding site [chemical binding]; other site 1294143000273 putative active site [active] 1294143000274 putative CoA binding site [chemical binding]; other site 1294143000275 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1294143000276 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1294143000277 Bacterial transcriptional regulator; Region: IclR; pfam01614 1294143000278 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1294143000279 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1294143000280 active site 1294143000281 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1294143000282 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1294143000283 FAD binding site [chemical binding]; other site 1294143000284 substrate binding site [chemical binding]; other site 1294143000285 catalytic base [active] 1294143000286 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1294143000287 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143000288 substrate binding site [chemical binding]; other site 1294143000289 oxyanion hole (OAH) forming residues; other site 1294143000290 trimer interface [polypeptide binding]; other site 1294143000291 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143000292 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143000293 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143000294 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143000295 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1294143000296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143000297 Coenzyme A binding pocket [chemical binding]; other site 1294143000298 transcriptional regulator; Provisional; Region: PRK10632 1294143000299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143000300 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143000301 putative effector binding pocket; other site 1294143000302 dimerization interface [polypeptide binding]; other site 1294143000303 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 1294143000304 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1294143000305 Predicted transcriptional regulator [Transcription]; Region: COG3905 1294143000306 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1294143000307 Na binding site [ion binding]; other site 1294143000308 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1294143000309 agmatinase; Region: agmatinase; TIGR01230 1294143000310 oligomer interface [polypeptide binding]; other site 1294143000311 putative active site [active] 1294143000312 Mn binding site [ion binding]; other site 1294143000313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143000314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143000315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143000316 dimerization interface [polypeptide binding]; other site 1294143000317 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1294143000318 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1294143000319 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1294143000320 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1294143000321 conserverd hypothetical protein; Region: TIGR02448 1294143000322 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1294143000323 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1294143000324 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143000325 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1294143000326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143000327 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1294143000328 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1294143000329 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1294143000330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143000331 S-adenosylmethionine binding site [chemical binding]; other site 1294143000332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143000333 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1294143000334 NAD(P) binding site [chemical binding]; other site 1294143000335 active site 1294143000336 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1294143000337 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1294143000338 NADP-binding site; other site 1294143000339 homotetramer interface [polypeptide binding]; other site 1294143000340 substrate binding site [chemical binding]; other site 1294143000341 homodimer interface [polypeptide binding]; other site 1294143000342 active site 1294143000343 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1294143000344 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1294143000345 Substrate binding site; other site 1294143000346 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1294143000347 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1294143000348 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1294143000349 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1294143000350 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1294143000351 Walker A/P-loop; other site 1294143000352 ATP binding site [chemical binding]; other site 1294143000353 Q-loop/lid; other site 1294143000354 ABC transporter signature motif; other site 1294143000355 Walker B; other site 1294143000356 D-loop; other site 1294143000357 H-loop/switch region; other site 1294143000358 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1294143000359 putative carbohydrate binding site [chemical binding]; other site 1294143000360 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1294143000361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143000362 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143000363 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1294143000364 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143000365 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1294143000366 putative ADP-binding pocket [chemical binding]; other site 1294143000367 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1294143000368 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1294143000369 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1294143000370 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1294143000371 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1294143000372 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1294143000373 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1294143000374 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1294143000375 ligand binding site [chemical binding]; other site 1294143000376 homodimer interface [polypeptide binding]; other site 1294143000377 NAD(P) binding site [chemical binding]; other site 1294143000378 trimer interface B [polypeptide binding]; other site 1294143000379 trimer interface A [polypeptide binding]; other site 1294143000380 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1294143000381 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1294143000382 Cu(I) binding site [ion binding]; other site 1294143000383 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1294143000384 UbiA prenyltransferase family; Region: UbiA; pfam01040 1294143000385 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1294143000386 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1294143000387 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1294143000388 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1294143000389 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1294143000390 Subunit III/VIIa interface [polypeptide binding]; other site 1294143000391 Phospholipid binding site [chemical binding]; other site 1294143000392 Subunit I/III interface [polypeptide binding]; other site 1294143000393 Subunit III/VIb interface [polypeptide binding]; other site 1294143000394 Subunit III/VIa interface; other site 1294143000395 Subunit III/Vb interface [polypeptide binding]; other site 1294143000396 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1294143000397 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1294143000398 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1294143000399 Subunit I/III interface [polypeptide binding]; other site 1294143000400 D-pathway; other site 1294143000401 Subunit I/VIIc interface [polypeptide binding]; other site 1294143000402 Subunit I/IV interface [polypeptide binding]; other site 1294143000403 Subunit I/II interface [polypeptide binding]; other site 1294143000404 Low-spin heme (heme a) binding site [chemical binding]; other site 1294143000405 Subunit I/VIIa interface [polypeptide binding]; other site 1294143000406 Subunit I/VIa interface [polypeptide binding]; other site 1294143000407 Dimer interface; other site 1294143000408 Putative water exit pathway; other site 1294143000409 Binuclear center (heme a3/CuB) [ion binding]; other site 1294143000410 K-pathway; other site 1294143000411 Subunit I/Vb interface [polypeptide binding]; other site 1294143000412 Putative proton exit pathway; other site 1294143000413 Subunit I/VIb interface; other site 1294143000414 Subunit I/VIc interface [polypeptide binding]; other site 1294143000415 Electron transfer pathway; other site 1294143000416 Subunit I/VIIIb interface [polypeptide binding]; other site 1294143000417 Subunit I/VIIb interface [polypeptide binding]; other site 1294143000418 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1294143000419 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1294143000420 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1294143000421 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1294143000422 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1294143000423 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1294143000424 active site clefts [active] 1294143000425 zinc binding site [ion binding]; other site 1294143000426 dimer interface [polypeptide binding]; other site 1294143000427 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1294143000428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143000429 FeS/SAM binding site; other site 1294143000430 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1294143000431 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1294143000432 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1294143000433 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1294143000434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143000435 motif II; other site 1294143000436 acetylornithine deacetylase; Provisional; Region: PRK07522 1294143000437 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1294143000438 metal binding site [ion binding]; metal-binding site 1294143000439 putative dimer interface [polypeptide binding]; other site 1294143000440 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1294143000441 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1294143000442 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1294143000443 homotrimer interaction site [polypeptide binding]; other site 1294143000444 putative active site [active] 1294143000445 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1294143000446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143000447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143000448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143000449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143000450 dimerization interface [polypeptide binding]; other site 1294143000451 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1294143000452 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143000453 inhibitor-cofactor binding pocket; inhibition site 1294143000454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143000455 catalytic residue [active] 1294143000456 Cupin domain; Region: Cupin_2; cl17218 1294143000457 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1294143000458 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1294143000459 tetrameric interface [polypeptide binding]; other site 1294143000460 NAD binding site [chemical binding]; other site 1294143000461 catalytic residues [active] 1294143000462 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143000463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143000464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143000465 Coenzyme A binding pocket [chemical binding]; other site 1294143000466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143000467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143000468 metal binding site [ion binding]; metal-binding site 1294143000469 active site 1294143000470 I-site; other site 1294143000471 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1294143000472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143000473 dimerization interface [polypeptide binding]; other site 1294143000474 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1294143000475 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1294143000476 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1294143000477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143000478 active site 1294143000479 phosphorylation site [posttranslational modification] 1294143000480 intermolecular recognition site; other site 1294143000481 dimerization interface [polypeptide binding]; other site 1294143000482 CheB methylesterase; Region: CheB_methylest; pfam01339 1294143000483 CheD chemotactic sensory transduction; Region: CheD; cl00810 1294143000484 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1294143000485 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1294143000486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143000487 PAS domain; Region: PAS_9; pfam13426 1294143000488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143000489 dimer interface [polypeptide binding]; other site 1294143000490 putative CheW interface [polypeptide binding]; other site 1294143000491 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1294143000492 putative CheA interaction surface; other site 1294143000493 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143000494 putative binding surface; other site 1294143000495 active site 1294143000496 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1294143000497 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1294143000498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143000499 ATP binding site [chemical binding]; other site 1294143000500 Mg2+ binding site [ion binding]; other site 1294143000501 G-X-G motif; other site 1294143000502 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1294143000503 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143000504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143000505 active site 1294143000506 phosphorylation site [posttranslational modification] 1294143000507 intermolecular recognition site; other site 1294143000508 dimerization interface [polypeptide binding]; other site 1294143000509 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1294143000510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143000511 dimer interface [polypeptide binding]; other site 1294143000512 putative CheW interface [polypeptide binding]; other site 1294143000513 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1294143000514 Sulfatase; Region: Sulfatase; pfam00884 1294143000515 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1294143000516 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1294143000517 Walker A/P-loop; other site 1294143000518 ATP binding site [chemical binding]; other site 1294143000519 Q-loop/lid; other site 1294143000520 ABC transporter signature motif; other site 1294143000521 Walker B; other site 1294143000522 D-loop; other site 1294143000523 H-loop/switch region; other site 1294143000524 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1294143000525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1294143000526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143000527 putative PBP binding loops; other site 1294143000528 ABC-ATPase subunit interface; other site 1294143000529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1294143000530 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1294143000531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143000532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143000533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143000534 dimerization interface [polypeptide binding]; other site 1294143000535 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1294143000536 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143000537 N-terminal plug; other site 1294143000538 ligand-binding site [chemical binding]; other site 1294143000539 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1294143000540 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1294143000541 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1294143000542 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1294143000543 active site 1294143000544 iron coordination sites [ion binding]; other site 1294143000545 substrate binding pocket [chemical binding]; other site 1294143000546 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1294143000547 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1294143000548 active site 1294143000549 putative substrate binding pocket [chemical binding]; other site 1294143000550 short chain dehydrogenase; Provisional; Region: PRK08177 1294143000551 NAD(P) binding site [chemical binding]; other site 1294143000552 active site 1294143000553 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1294143000554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143000555 putative substrate translocation pore; other site 1294143000556 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143000557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143000558 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1294143000559 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1294143000560 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1294143000561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143000562 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1294143000563 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1294143000564 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1294143000565 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1294143000566 Cache domain; Region: Cache_1; pfam02743 1294143000567 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143000568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143000569 dimer interface [polypeptide binding]; other site 1294143000570 putative CheW interface [polypeptide binding]; other site 1294143000571 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1294143000572 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1294143000573 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1294143000574 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1294143000575 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1294143000576 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1294143000577 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1294143000578 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143000579 catalytic loop [active] 1294143000580 iron binding site [ion binding]; other site 1294143000581 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1294143000582 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1294143000583 beta-alpha-beta structure motif; other site 1294143000584 NAD binding pocket [chemical binding]; other site 1294143000585 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1294143000586 peroxiredoxin; Region: AhpC; TIGR03137 1294143000587 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1294143000588 dimer interface [polypeptide binding]; other site 1294143000589 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1294143000590 catalytic triad [active] 1294143000591 peroxidatic and resolving cysteines [active] 1294143000592 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1294143000593 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1294143000594 catalytic residue [active] 1294143000595 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1294143000596 catalytic residues [active] 1294143000597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143000598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143000599 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1294143000600 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1294143000601 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1294143000602 putative active site [active] 1294143000603 catalytic site [active] 1294143000604 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1294143000605 putative active site [active] 1294143000606 catalytic site [active] 1294143000607 amidase; Provisional; Region: PRK07042 1294143000608 Amidase; Region: Amidase; cl11426 1294143000609 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1294143000610 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1294143000611 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1294143000612 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1294143000613 putative active site pocket [active] 1294143000614 dimerization interface [polypeptide binding]; other site 1294143000615 putative catalytic residue [active] 1294143000616 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1294143000617 TolR protein; Region: tolR; TIGR02801 1294143000618 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1294143000619 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1294143000620 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1294143000621 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1294143000622 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1294143000623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143000624 dimer interface [polypeptide binding]; other site 1294143000625 conserved gate region; other site 1294143000626 ABC-ATPase subunit interface; other site 1294143000627 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1294143000628 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1294143000629 Walker A/P-loop; other site 1294143000630 ATP binding site [chemical binding]; other site 1294143000631 Q-loop/lid; other site 1294143000632 ABC transporter signature motif; other site 1294143000633 Walker B; other site 1294143000634 D-loop; other site 1294143000635 H-loop/switch region; other site 1294143000636 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1294143000637 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1294143000638 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1294143000639 dimer interface [polypeptide binding]; other site 1294143000640 putative PBP binding regions; other site 1294143000641 ABC-ATPase subunit interface; other site 1294143000642 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1294143000643 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1294143000644 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1294143000645 metal binding site 2 [ion binding]; metal-binding site 1294143000646 putative DNA binding helix; other site 1294143000647 metal binding site 1 [ion binding]; metal-binding site 1294143000648 dimer interface [polypeptide binding]; other site 1294143000649 structural Zn2+ binding site [ion binding]; other site 1294143000650 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1294143000651 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1294143000652 metal binding site [ion binding]; metal-binding site 1294143000653 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1294143000654 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1294143000655 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1294143000656 active site 1294143000657 dimer interface [polypeptide binding]; other site 1294143000658 effector binding site; other site 1294143000659 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1294143000660 TSCPD domain; Region: TSCPD; pfam12637 1294143000661 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1294143000662 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1294143000663 putative active site [active] 1294143000664 putative substrate binding site [chemical binding]; other site 1294143000665 ATP binding site [chemical binding]; other site 1294143000666 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1294143000667 DNA polymerase I; Provisional; Region: PRK05755 1294143000668 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1294143000669 active site 1294143000670 metal binding site 1 [ion binding]; metal-binding site 1294143000671 putative 5' ssDNA interaction site; other site 1294143000672 metal binding site 3; metal-binding site 1294143000673 metal binding site 2 [ion binding]; metal-binding site 1294143000674 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1294143000675 putative DNA binding site [nucleotide binding]; other site 1294143000676 putative metal binding site [ion binding]; other site 1294143000677 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1294143000678 active site 1294143000679 catalytic site [active] 1294143000680 substrate binding site [chemical binding]; other site 1294143000681 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1294143000682 active site 1294143000683 DNA binding site [nucleotide binding] 1294143000684 catalytic site [active] 1294143000685 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1294143000686 G1 box; other site 1294143000687 GTP/Mg2+ binding site [chemical binding]; other site 1294143000688 Switch I region; other site 1294143000689 G2 box; other site 1294143000690 G3 box; other site 1294143000691 Switch II region; other site 1294143000692 G4 box; other site 1294143000693 G5 box; other site 1294143000694 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1294143000695 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1294143000696 Cytochrome c; Region: Cytochrom_C; cl11414 1294143000697 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1294143000698 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1294143000699 catalytic residues [active] 1294143000700 hinge region; other site 1294143000701 alpha helical domain; other site 1294143000702 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1294143000703 putative catalytic site [active] 1294143000704 putative metal binding site [ion binding]; other site 1294143000705 putative phosphate binding site [ion binding]; other site 1294143000706 putative catalytic site [active] 1294143000707 putative phosphate binding site [ion binding]; other site 1294143000708 putative metal binding site [ion binding]; other site 1294143000709 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143000710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143000711 metal binding site [ion binding]; metal-binding site 1294143000712 active site 1294143000713 I-site; other site 1294143000714 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1294143000715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143000716 putative DNA binding site [nucleotide binding]; other site 1294143000717 putative Zn2+ binding site [ion binding]; other site 1294143000718 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1294143000719 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1294143000720 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1294143000721 glutaminase active site [active] 1294143000722 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1294143000723 dimer interface [polypeptide binding]; other site 1294143000724 active site 1294143000725 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1294143000726 dimer interface [polypeptide binding]; other site 1294143000727 active site 1294143000728 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1294143000729 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1294143000730 putative NAD(P) binding site [chemical binding]; other site 1294143000731 active site 1294143000732 putative substrate binding site [chemical binding]; other site 1294143000733 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1294143000734 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1294143000735 Ligand binding site; other site 1294143000736 Putative Catalytic site; other site 1294143000737 DXD motif; other site 1294143000738 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1294143000739 SdiA-regulated; Region: SdiA-regulated; pfam06977 1294143000740 SdiA-regulated; Region: SdiA-regulated; cd09971 1294143000741 putative active site [active] 1294143000742 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 1294143000743 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 1294143000744 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1294143000745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143000746 putative substrate translocation pore; other site 1294143000747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143000748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143000749 putative substrate translocation pore; other site 1294143000750 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1294143000751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143000752 S-adenosylmethionine binding site [chemical binding]; other site 1294143000753 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1294143000754 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1294143000755 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1294143000756 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1294143000757 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1294143000758 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1294143000759 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1294143000760 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1294143000761 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1294143000762 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1294143000763 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1294143000764 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1294143000765 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1294143000766 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1294143000767 active site 1294143000768 purine riboside binding site [chemical binding]; other site 1294143000769 putative transporter; Provisional; Region: PRK11660 1294143000770 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1294143000771 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1294143000772 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1294143000773 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1294143000774 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1294143000775 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1294143000776 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1294143000777 Predicted permeases [General function prediction only]; Region: COG0679 1294143000778 short chain dehydrogenase; Provisional; Region: PRK12828 1294143000779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143000780 NAD(P) binding site [chemical binding]; other site 1294143000781 active site 1294143000782 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1294143000783 active site 1294143000784 metal binding site [ion binding]; metal-binding site 1294143000785 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1294143000786 FOG: CBS domain [General function prediction only]; Region: COG0517 1294143000787 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143000788 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143000789 catalytic residue [active] 1294143000790 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1294143000791 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1294143000792 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1294143000793 tetramerization interface [polypeptide binding]; other site 1294143000794 NAD(P) binding site [chemical binding]; other site 1294143000795 catalytic residues [active] 1294143000796 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1294143000797 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143000798 inhibitor-cofactor binding pocket; inhibition site 1294143000799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143000800 catalytic residue [active] 1294143000801 argininosuccinate lyase; Provisional; Region: PRK00855 1294143000802 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1294143000803 active sites [active] 1294143000804 tetramer interface [polypeptide binding]; other site 1294143000805 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1294143000806 Histidine kinase; Region: His_kinase; pfam06580 1294143000807 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1294143000808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143000809 active site 1294143000810 phosphorylation site [posttranslational modification] 1294143000811 intermolecular recognition site; other site 1294143000812 dimerization interface [polypeptide binding]; other site 1294143000813 LytTr DNA-binding domain; Region: LytTR; pfam04397 1294143000814 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1294143000815 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1294143000816 domain interfaces; other site 1294143000817 active site 1294143000818 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1294143000819 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1294143000820 active site 1294143000821 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1294143000822 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 1294143000823 HemY protein N-terminus; Region: HemY_N; pfam07219 1294143000824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143000825 binding surface 1294143000826 TPR motif; other site 1294143000827 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1294143000828 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1294143000829 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1294143000830 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1294143000831 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1294143000832 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1294143000833 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1294143000834 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1294143000835 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1294143000836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143000837 Walker A/P-loop; other site 1294143000838 ATP binding site [chemical binding]; other site 1294143000839 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143000840 ABC transporter signature motif; other site 1294143000841 Walker B; other site 1294143000842 D-loop; other site 1294143000843 ABC transporter; Region: ABC_tran_2; pfam12848 1294143000844 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143000845 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1294143000846 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1294143000847 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1294143000848 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1294143000849 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1294143000850 LysE type translocator; Region: LysE; cl00565 1294143000851 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1294143000852 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143000853 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1294143000854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1294143000855 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1294143000856 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1294143000857 conserved cys residue [active] 1294143000858 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1294143000859 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1294143000860 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1294143000861 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1294143000862 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1294143000863 dimer interface [polypeptide binding]; other site 1294143000864 active site 1294143000865 aspartate-rich active site metal binding site; other site 1294143000866 allosteric magnesium binding site [ion binding]; other site 1294143000867 Schiff base residues; other site 1294143000868 polyphosphate kinase; Provisional; Region: PRK05443 1294143000869 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1294143000870 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1294143000871 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1294143000872 putative domain interface [polypeptide binding]; other site 1294143000873 putative active site [active] 1294143000874 catalytic site [active] 1294143000875 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1294143000876 putative domain interface [polypeptide binding]; other site 1294143000877 putative active site [active] 1294143000878 catalytic site [active] 1294143000879 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1294143000880 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1294143000881 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1294143000882 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1294143000883 catalytic residues [active] 1294143000884 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1294143000885 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1294143000886 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1294143000887 RNA binding site [nucleotide binding]; other site 1294143000888 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1294143000889 multimer interface [polypeptide binding]; other site 1294143000890 Walker A motif; other site 1294143000891 ATP binding site [chemical binding]; other site 1294143000892 Walker B motif; other site 1294143000893 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1294143000894 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1294143000895 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143000896 catalytic loop [active] 1294143000897 iron binding site [ion binding]; other site 1294143000898 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1294143000899 FAD binding pocket [chemical binding]; other site 1294143000900 FAD binding motif [chemical binding]; other site 1294143000901 phosphate binding motif [ion binding]; other site 1294143000902 beta-alpha-beta structure motif; other site 1294143000903 NAD binding pocket [chemical binding]; other site 1294143000904 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1294143000905 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1294143000906 NAD(P) binding site [chemical binding]; other site 1294143000907 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 1294143000908 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1294143000909 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143000910 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143000911 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1294143000912 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1294143000913 Walker A/P-loop; other site 1294143000914 ATP binding site [chemical binding]; other site 1294143000915 Q-loop/lid; other site 1294143000916 ABC transporter signature motif; other site 1294143000917 Walker B; other site 1294143000918 D-loop; other site 1294143000919 H-loop/switch region; other site 1294143000920 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1294143000921 Walker A/P-loop; other site 1294143000922 ATP binding site [chemical binding]; other site 1294143000923 Q-loop/lid; other site 1294143000924 ABC transporter signature motif; other site 1294143000925 Walker B; other site 1294143000926 D-loop; other site 1294143000927 H-loop/switch region; other site 1294143000928 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143000929 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1294143000930 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143000931 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1294143000932 CHASE domain; Region: CHASE; cl01369 1294143000933 PAS domain S-box; Region: sensory_box; TIGR00229 1294143000934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143000935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143000936 metal binding site [ion binding]; metal-binding site 1294143000937 active site 1294143000938 I-site; other site 1294143000939 Uncharacterized conserved protein [Function unknown]; Region: COG2947 1294143000940 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1294143000941 Cell division protein ZapA; Region: ZapA; pfam05164 1294143000942 TIGR02449 family protein; Region: TIGR02449 1294143000943 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1294143000944 proline aminopeptidase P II; Provisional; Region: PRK10879 1294143000945 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1294143000946 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1294143000947 active site 1294143000948 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1294143000949 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1294143000950 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1294143000951 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1294143000952 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143000953 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1294143000954 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1294143000955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143000956 dimer interface [polypeptide binding]; other site 1294143000957 conserved gate region; other site 1294143000958 putative PBP binding loops; other site 1294143000959 ABC-ATPase subunit interface; other site 1294143000960 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1294143000961 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1294143000962 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1294143000963 lipoyl attachment site [posttranslational modification]; other site 1294143000964 glycine dehydrogenase; Provisional; Region: PRK05367 1294143000965 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1294143000966 tetramer interface [polypeptide binding]; other site 1294143000967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143000968 catalytic residue [active] 1294143000969 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1294143000970 tetramer interface [polypeptide binding]; other site 1294143000971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143000972 catalytic residue [active] 1294143000973 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1294143000974 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1294143000975 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1294143000976 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 1294143000977 HEAT repeats; Region: HEAT_2; pfam13646 1294143000978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143000979 TPR motif; other site 1294143000980 TPR repeat; Region: TPR_11; pfam13414 1294143000981 binding surface 1294143000982 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1294143000983 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1294143000984 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1294143000985 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143000986 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1294143000987 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1294143000988 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1294143000989 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1294143000990 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1294143000991 dimerization interface [polypeptide binding]; other site 1294143000992 active site 1294143000993 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1294143000994 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1294143000995 putative active site [active] 1294143000996 metal binding site [ion binding]; metal-binding site 1294143000997 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1294143000998 active site 1294143000999 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1294143001000 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1294143001001 putative molybdopterin cofactor binding site [chemical binding]; other site 1294143001002 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1294143001003 putative molybdopterin cofactor binding site; other site 1294143001004 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 1294143001005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143001006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143001007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143001008 dimerization interface [polypeptide binding]; other site 1294143001009 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1294143001010 BON domain; Region: BON; pfam04972 1294143001011 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143001012 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1294143001013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143001014 motif II; other site 1294143001015 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1294143001016 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1294143001017 dimer interface [polypeptide binding]; other site 1294143001018 ADP-ribose binding site [chemical binding]; other site 1294143001019 active site 1294143001020 nudix motif; other site 1294143001021 metal binding site [ion binding]; metal-binding site 1294143001022 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1294143001023 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1294143001024 active site 1294143001025 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1294143001026 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1294143001027 DNA binding site [nucleotide binding] 1294143001028 catalytic residue [active] 1294143001029 H2TH interface [polypeptide binding]; other site 1294143001030 putative catalytic residues [active] 1294143001031 turnover-facilitating residue; other site 1294143001032 intercalation triad [nucleotide binding]; other site 1294143001033 8OG recognition residue [nucleotide binding]; other site 1294143001034 putative reading head residues; other site 1294143001035 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1294143001036 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1294143001037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 1294143001038 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1294143001039 putative acyl-acceptor binding pocket; other site 1294143001040 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1294143001041 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1294143001042 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1294143001043 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1294143001044 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1294143001045 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1294143001046 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1294143001047 active site 1294143001048 (T/H)XGH motif; other site 1294143001049 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1294143001050 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1294143001051 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1294143001052 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1294143001053 NAD(P) binding site [chemical binding]; other site 1294143001054 catalytic residues [active] 1294143001055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143001056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143001057 Bacterial transcriptional repressor; Region: TetR; pfam13972 1294143001058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143001059 Coenzyme A binding pocket [chemical binding]; other site 1294143001060 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1294143001061 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1294143001062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143001063 S-adenosylmethionine binding site [chemical binding]; other site 1294143001064 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1294143001065 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1294143001066 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1294143001067 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1294143001068 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1294143001069 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1294143001070 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1294143001071 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1294143001072 P loop; other site 1294143001073 GTP binding site [chemical binding]; other site 1294143001074 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1294143001075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143001076 Walker A/P-loop; other site 1294143001077 ATP binding site [chemical binding]; other site 1294143001078 Q-loop/lid; other site 1294143001079 ABC transporter signature motif; other site 1294143001080 Walker B; other site 1294143001081 D-loop; other site 1294143001082 H-loop/switch region; other site 1294143001083 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1294143001084 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1294143001085 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1294143001086 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1294143001087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143001088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143001089 DNA binding residues [nucleotide binding] 1294143001090 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1294143001091 Transglycosylase; Region: Transgly; cl17702 1294143001092 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1294143001093 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1294143001094 thiS-thiF/thiG interaction site; other site 1294143001095 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1294143001096 ThiS interaction site; other site 1294143001097 putative active site [active] 1294143001098 tetramer interface [polypeptide binding]; other site 1294143001099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143001100 S-adenosylmethionine binding site [chemical binding]; other site 1294143001101 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143001102 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 1294143001103 HemN family oxidoreductase; Provisional; Region: PRK05660 1294143001104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143001105 FeS/SAM binding site; other site 1294143001106 HemN C-terminal domain; Region: HemN_C; pfam06969 1294143001107 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1294143001108 active site 1294143001109 dimerization interface [polypeptide binding]; other site 1294143001110 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1294143001111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143001112 S-adenosylmethionine binding site [chemical binding]; other site 1294143001113 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1294143001114 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1294143001115 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1294143001116 G1 box; other site 1294143001117 GTP/Mg2+ binding site [chemical binding]; other site 1294143001118 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1294143001119 G2 box; other site 1294143001120 Switch I region; other site 1294143001121 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1294143001122 G3 box; other site 1294143001123 Switch II region; other site 1294143001124 GTP/Mg2+ binding site [chemical binding]; other site 1294143001125 G4 box; other site 1294143001126 G5 box; other site 1294143001127 hypothetical protein; Validated; Region: PRK05090 1294143001128 YGGT family; Region: YGGT; pfam02325 1294143001129 YGGT family; Region: YGGT; pfam02325 1294143001130 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1294143001131 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1294143001132 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1294143001133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1294143001134 catalytic residue [active] 1294143001135 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1294143001136 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1294143001137 Walker A motif; other site 1294143001138 ATP binding site [chemical binding]; other site 1294143001139 Walker B motif; other site 1294143001140 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1294143001141 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1294143001142 Walker A motif; other site 1294143001143 ATP binding site [chemical binding]; other site 1294143001144 Walker B motif; other site 1294143001145 TM2 domain; Region: TM2; cl00984 1294143001146 TM2 domain; Region: TM2; cl00984 1294143001147 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1294143001148 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1294143001149 dimer interface [polypeptide binding]; other site 1294143001150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143001151 catalytic residue [active] 1294143001152 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1294143001153 FOG: CBS domain [General function prediction only]; Region: COG0517 1294143001154 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1294143001155 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1294143001156 homodimer interface [polypeptide binding]; other site 1294143001157 substrate-cofactor binding pocket; other site 1294143001158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143001159 catalytic residue [active] 1294143001160 dihydroorotase; Validated; Region: pyrC; PRK09357 1294143001161 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1294143001162 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1294143001163 active site 1294143001164 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1294143001165 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1294143001166 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1294143001167 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1294143001168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143001169 active site 1294143001170 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1294143001171 hypothetical protein; Validated; Region: PRK00228 1294143001172 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1294143001173 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1294143001174 glutathione synthetase; Provisional; Region: PRK05246 1294143001175 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1294143001176 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1294143001177 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143001178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143001179 active site 1294143001180 phosphorylation site [posttranslational modification] 1294143001181 intermolecular recognition site; other site 1294143001182 dimerization interface [polypeptide binding]; other site 1294143001183 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143001184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143001185 active site 1294143001186 phosphorylation site [posttranslational modification] 1294143001187 intermolecular recognition site; other site 1294143001188 dimerization interface [polypeptide binding]; other site 1294143001189 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1294143001190 putative CheA interaction surface; other site 1294143001191 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1294143001192 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143001193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143001194 dimer interface [polypeptide binding]; other site 1294143001195 putative CheW interface [polypeptide binding]; other site 1294143001196 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1294143001197 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1294143001198 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1294143001199 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143001200 putative binding surface; other site 1294143001201 active site 1294143001202 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143001203 putative binding surface; other site 1294143001204 active site 1294143001205 Hpt domain; Region: Hpt; pfam01627 1294143001206 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143001207 putative binding surface; other site 1294143001208 active site 1294143001209 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143001210 putative binding surface; other site 1294143001211 active site 1294143001212 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143001213 putative binding surface; other site 1294143001214 active site 1294143001215 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1294143001216 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1294143001217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143001218 ATP binding site [chemical binding]; other site 1294143001219 Mg2+ binding site [ion binding]; other site 1294143001220 G-X-G motif; other site 1294143001221 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1294143001222 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143001223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143001224 active site 1294143001225 phosphorylation site [posttranslational modification] 1294143001226 intermolecular recognition site; other site 1294143001227 dimerization interface [polypeptide binding]; other site 1294143001228 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1294143001229 CheB methylesterase; Region: CheB_methylest; pfam01339 1294143001230 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1294143001231 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1294143001232 RNA methyltransferase, RsmE family; Region: TIGR00046 1294143001233 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1294143001234 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143001235 inhibitor-cofactor binding pocket; inhibition site 1294143001236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143001237 catalytic residue [active] 1294143001238 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1294143001239 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1294143001240 hypothetical protein; Provisional; Region: PRK03757 1294143001241 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1294143001242 MarR family; Region: MarR; pfam01047 1294143001243 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1294143001244 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143001245 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143001246 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1294143001247 Protein export membrane protein; Region: SecD_SecF; cl14618 1294143001248 Protein export membrane protein; Region: SecD_SecF; cl14618 1294143001249 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1294143001250 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 1294143001251 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1294143001252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143001253 dimerization interface [polypeptide binding]; other site 1294143001254 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143001255 dimer interface [polypeptide binding]; other site 1294143001256 putative CheW interface [polypeptide binding]; other site 1294143001257 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1294143001258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143001259 dimerization interface [polypeptide binding]; other site 1294143001260 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143001261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143001262 dimer interface [polypeptide binding]; other site 1294143001263 putative CheW interface [polypeptide binding]; other site 1294143001264 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1294143001265 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1294143001266 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1294143001267 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 1294143001268 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 1294143001269 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1294143001270 metal binding site [ion binding]; metal-binding site 1294143001271 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1294143001272 ABC1 family; Region: ABC1; cl17513 1294143001273 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1294143001274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1294143001275 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1294143001276 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1294143001277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143001278 S-adenosylmethionine binding site [chemical binding]; other site 1294143001279 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 1294143001280 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1294143001281 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1294143001282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143001283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143001284 Bacterial transcriptional repressor; Region: TetR; pfam13972 1294143001285 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1294143001286 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1294143001287 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1294143001288 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1294143001289 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1294143001290 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1294143001291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1294143001292 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1294143001293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143001294 Walker A motif; other site 1294143001295 ATP binding site [chemical binding]; other site 1294143001296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143001297 Walker B motif; other site 1294143001298 arginine finger; other site 1294143001299 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1294143001300 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1294143001301 active site 1294143001302 HslU subunit interaction site [polypeptide binding]; other site 1294143001303 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 1294143001304 Sporulation related domain; Region: SPOR; pfam05036 1294143001305 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1294143001306 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1294143001307 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1294143001308 active site 1294143001309 HIGH motif; other site 1294143001310 KMSK motif region; other site 1294143001311 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1294143001312 tRNA binding surface [nucleotide binding]; other site 1294143001313 anticodon binding site; other site 1294143001314 primosome assembly protein PriA; Validated; Region: PRK05580 1294143001315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143001316 ATP binding site [chemical binding]; other site 1294143001317 putative Mg++ binding site [ion binding]; other site 1294143001318 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1294143001319 nucleotide binding region [chemical binding]; other site 1294143001320 ATP-binding site [chemical binding]; other site 1294143001321 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1294143001322 Staphylococcal nuclease homologues; Region: SNc; smart00318 1294143001323 Catalytic site; other site 1294143001324 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1294143001325 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 1294143001326 Peptidase family M48; Region: Peptidase_M48; pfam01435 1294143001327 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1294143001328 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1294143001329 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1294143001330 putative NAD(P) binding site [chemical binding]; other site 1294143001331 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1294143001332 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1294143001333 active site residues [active] 1294143001334 dimer interface [polypeptide binding]; other site 1294143001335 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1294143001336 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1294143001337 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1294143001338 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1294143001339 active site 1294143001340 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1294143001341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143001342 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143001343 substrate binding pocket [chemical binding]; other site 1294143001344 membrane-bound complex binding site; other site 1294143001345 hinge residues; other site 1294143001346 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1294143001347 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1294143001348 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1294143001349 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1294143001350 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1294143001351 ATP binding site [chemical binding]; other site 1294143001352 Mg++ binding site [ion binding]; other site 1294143001353 motif III; other site 1294143001354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143001355 nucleotide binding region [chemical binding]; other site 1294143001356 ATP-binding site [chemical binding]; other site 1294143001357 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1294143001358 putative RNA binding site [nucleotide binding]; other site 1294143001359 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1294143001360 DNA-binding site [nucleotide binding]; DNA binding site 1294143001361 RNA-binding motif; other site 1294143001362 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1294143001363 putative transporter; Provisional; Region: PRK10504 1294143001364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143001365 putative substrate translocation pore; other site 1294143001366 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1294143001367 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1294143001368 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1294143001369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1294143001370 putative acyl-acceptor binding pocket; other site 1294143001371 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1294143001372 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1294143001373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143001374 active site 1294143001375 phosphorylation site [posttranslational modification] 1294143001376 intermolecular recognition site; other site 1294143001377 dimerization interface [polypeptide binding]; other site 1294143001378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143001379 DNA binding site [nucleotide binding] 1294143001380 sensory histidine kinase CreC; Provisional; Region: PRK11100 1294143001381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143001382 dimer interface [polypeptide binding]; other site 1294143001383 phosphorylation site [posttranslational modification] 1294143001384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143001385 ATP binding site [chemical binding]; other site 1294143001386 Mg2+ binding site [ion binding]; other site 1294143001387 G-X-G motif; other site 1294143001388 inner membrane protein; Provisional; Region: PRK11715 1294143001389 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1294143001390 putative glutathione S-transferase; Provisional; Region: PRK10357 1294143001391 putative C-terminal domain interface [polypeptide binding]; other site 1294143001392 putative GSH binding site (G-site) [chemical binding]; other site 1294143001393 putative dimer interface [polypeptide binding]; other site 1294143001394 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1294143001395 dimer interface [polypeptide binding]; other site 1294143001396 N-terminal domain interface [polypeptide binding]; other site 1294143001397 putative substrate binding pocket (H-site) [chemical binding]; other site 1294143001398 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1294143001399 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1294143001400 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1294143001401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143001402 N-terminal plug; other site 1294143001403 ligand-binding site [chemical binding]; other site 1294143001404 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1294143001405 FecR protein; Region: FecR; pfam04773 1294143001406 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1294143001407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143001408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143001409 DNA binding residues [nucleotide binding] 1294143001410 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1294143001411 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1294143001412 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1294143001413 Na binding site [ion binding]; other site 1294143001414 putative substrate binding site [chemical binding]; other site 1294143001415 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1294143001416 active site 1294143001417 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1294143001418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143001419 Coenzyme A binding pocket [chemical binding]; other site 1294143001420 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1294143001421 ACT domain; Region: ACT_6; pfam13740 1294143001422 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1294143001423 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1294143001424 EamA-like transporter family; Region: EamA; pfam00892 1294143001425 serine/threonine protein kinase; Provisional; Region: PRK11768 1294143001426 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1294143001427 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1294143001428 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143001429 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1294143001430 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1294143001431 TOBE domain; Region: TOBE; cl01440 1294143001432 TOBE domain; Region: TOBE; pfam03459 1294143001433 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1294143001434 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143001435 active site 1294143001436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143001437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143001438 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1294143001439 putative substrate binding pocket [chemical binding]; other site 1294143001440 dimerization interface [polypeptide binding]; other site 1294143001441 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 1294143001442 putative active site [active] 1294143001443 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1294143001444 carboxyltransferase (CT) interaction site; other site 1294143001445 biotinylation site [posttranslational modification]; other site 1294143001446 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 1294143001447 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1294143001448 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143001449 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1294143001450 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1294143001451 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1294143001452 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1294143001453 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1294143001454 biotin synthase; Provisional; Region: PRK15108 1294143001455 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143001456 FeS/SAM binding site; other site 1294143001457 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1294143001458 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1294143001459 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1294143001460 substrate-cofactor binding pocket; other site 1294143001461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143001462 catalytic residue [active] 1294143001463 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1294143001464 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1294143001465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143001466 S-adenosylmethionine binding site [chemical binding]; other site 1294143001467 AAA domain; Region: AAA_26; pfam13500 1294143001468 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1294143001469 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 1294143001470 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1294143001471 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143001472 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143001473 active site 1294143001474 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143001475 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143001476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143001477 metal binding site [ion binding]; metal-binding site 1294143001478 active site 1294143001479 I-site; other site 1294143001480 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1294143001481 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143001482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143001483 active site 1294143001484 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143001485 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1294143001486 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143001487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143001488 active site 1294143001489 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143001490 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1294143001491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143001492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143001493 dimerization interface [polypeptide binding]; other site 1294143001494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1294143001495 MOSC domain; Region: MOSC; pfam03473 1294143001496 3-alpha domain; Region: 3-alpha; pfam03475 1294143001497 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1294143001498 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1294143001499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143001500 ligand binding site [chemical binding]; other site 1294143001501 flexible hinge region; other site 1294143001502 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1294143001503 putative switch regulator; other site 1294143001504 non-specific DNA interactions [nucleotide binding]; other site 1294143001505 DNA binding site [nucleotide binding] 1294143001506 sequence specific DNA binding site [nucleotide binding]; other site 1294143001507 putative cAMP binding site [chemical binding]; other site 1294143001508 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1294143001509 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1294143001510 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1294143001511 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143001512 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143001513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143001514 non-specific DNA binding site [nucleotide binding]; other site 1294143001515 salt bridge; other site 1294143001516 sequence-specific DNA binding site [nucleotide binding]; other site 1294143001517 Cupin domain; Region: Cupin_2; pfam07883 1294143001518 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1294143001519 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1294143001520 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1294143001521 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143001522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143001523 substrate binding pocket [chemical binding]; other site 1294143001524 membrane-bound complex binding site; other site 1294143001525 hinge residues; other site 1294143001526 PAS domain S-box; Region: sensory_box; TIGR00229 1294143001527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143001528 putative active site [active] 1294143001529 heme pocket [chemical binding]; other site 1294143001530 PAS domain S-box; Region: sensory_box; TIGR00229 1294143001531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143001532 putative active site [active] 1294143001533 heme pocket [chemical binding]; other site 1294143001534 PAS domain S-box; Region: sensory_box; TIGR00229 1294143001535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143001536 putative active site [active] 1294143001537 heme pocket [chemical binding]; other site 1294143001538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143001539 PAS domain; Region: PAS_9; pfam13426 1294143001540 putative active site [active] 1294143001541 heme pocket [chemical binding]; other site 1294143001542 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143001543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143001544 metal binding site [ion binding]; metal-binding site 1294143001545 active site 1294143001546 I-site; other site 1294143001547 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143001548 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1294143001549 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1294143001550 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1294143001551 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1294143001552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143001553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1294143001554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143001555 DNA binding residues [nucleotide binding] 1294143001556 DNA primase, catalytic core; Region: dnaG; TIGR01391 1294143001557 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1294143001558 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1294143001559 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1294143001560 active site 1294143001561 metal binding site [ion binding]; metal-binding site 1294143001562 interdomain interaction site; other site 1294143001563 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1294143001564 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1294143001565 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1294143001566 UGMP family protein; Validated; Region: PRK09604 1294143001567 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1294143001568 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1294143001569 Dihydroneopterin aldolase; Region: FolB; smart00905 1294143001570 active site 1294143001571 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1294143001572 catalytic center binding site [active] 1294143001573 ATP binding site [chemical binding]; other site 1294143001574 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1294143001575 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1294143001576 active site 1294143001577 NTP binding site [chemical binding]; other site 1294143001578 metal binding triad [ion binding]; metal-binding site 1294143001579 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1294143001580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1294143001581 Zn2+ binding site [ion binding]; other site 1294143001582 Mg2+ binding site [ion binding]; other site 1294143001583 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1294143001584 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1294143001585 SpoVR family protein; Provisional; Region: PRK11767 1294143001586 hypothetical protein; Provisional; Region: PRK05325 1294143001587 PrkA family serine protein kinase; Provisional; Region: PRK15455 1294143001588 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1294143001589 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1294143001590 active site residue [active] 1294143001591 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1294143001592 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1294143001593 active site 1294143001594 metal binding site [ion binding]; metal-binding site 1294143001595 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1294143001596 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1294143001597 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1294143001598 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1294143001599 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1294143001600 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1294143001601 SurA N-terminal domain; Region: SurA_N; pfam09312 1294143001602 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1294143001603 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1294143001604 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1294143001605 OstA-like protein; Region: OstA; cl00844 1294143001606 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1294143001607 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1294143001608 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1294143001609 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1294143001610 putative active site [active] 1294143001611 putative NTP binding site [chemical binding]; other site 1294143001612 putative nucleic acid binding site [nucleotide binding]; other site 1294143001613 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1294143001614 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1294143001615 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1294143001616 active site 1294143001617 Phosphotransferase enzyme family; Region: APH; pfam01636 1294143001618 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1294143001619 active site 1294143001620 ATP binding site [chemical binding]; other site 1294143001621 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1294143001622 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1294143001623 Substrate binding site; other site 1294143001624 metal-binding site 1294143001625 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1294143001626 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1294143001627 putative metal binding site [ion binding]; other site 1294143001628 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1294143001629 HSP70 interaction site [polypeptide binding]; other site 1294143001630 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1294143001631 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143001632 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143001633 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143001634 substrate binding pocket [chemical binding]; other site 1294143001635 membrane-bound complex binding site; other site 1294143001636 hinge residues; other site 1294143001637 PAS domain; Region: PAS_9; pfam13426 1294143001638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143001639 putative active site [active] 1294143001640 heme pocket [chemical binding]; other site 1294143001641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143001642 Histidine kinase; Region: HisKA_3; pfam07730 1294143001643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143001644 ATP binding site [chemical binding]; other site 1294143001645 Mg2+ binding site [ion binding]; other site 1294143001646 G-X-G motif; other site 1294143001647 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143001648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143001649 active site 1294143001650 phosphorylation site [posttranslational modification] 1294143001651 intermolecular recognition site; other site 1294143001652 dimerization interface [polypeptide binding]; other site 1294143001653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143001654 DNA binding residues [nucleotide binding] 1294143001655 dimerization interface [polypeptide binding]; other site 1294143001656 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143001657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143001658 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1294143001659 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1294143001660 Walker A/P-loop; other site 1294143001661 ATP binding site [chemical binding]; other site 1294143001662 Q-loop/lid; other site 1294143001663 ABC transporter signature motif; other site 1294143001664 Walker B; other site 1294143001665 D-loop; other site 1294143001666 H-loop/switch region; other site 1294143001667 TOBE domain; Region: TOBE_2; pfam08402 1294143001668 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143001669 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143001670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143001671 dimer interface [polypeptide binding]; other site 1294143001672 conserved gate region; other site 1294143001673 putative PBP binding loops; other site 1294143001674 ABC-ATPase subunit interface; other site 1294143001675 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1294143001676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143001677 dimer interface [polypeptide binding]; other site 1294143001678 conserved gate region; other site 1294143001679 putative PBP binding loops; other site 1294143001680 ABC-ATPase subunit interface; other site 1294143001681 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1294143001682 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1294143001683 substrate binding site [chemical binding]; other site 1294143001684 hexamer interface [polypeptide binding]; other site 1294143001685 metal binding site [ion binding]; metal-binding site 1294143001686 phosphoglycolate phosphatase; Provisional; Region: PRK13223 1294143001687 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1294143001688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143001689 motif II; other site 1294143001690 anthranilate synthase component I; Provisional; Region: PRK13565 1294143001691 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1294143001692 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1294143001693 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1294143001694 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1294143001695 glutamine binding [chemical binding]; other site 1294143001696 catalytic triad [active] 1294143001697 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1294143001698 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1294143001699 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1294143001700 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1294143001701 active site 1294143001702 ribulose/triose binding site [chemical binding]; other site 1294143001703 phosphate binding site [ion binding]; other site 1294143001704 substrate (anthranilate) binding pocket [chemical binding]; other site 1294143001705 product (indole) binding pocket [chemical binding]; other site 1294143001706 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1294143001707 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143001708 ligand binding site [chemical binding]; other site 1294143001709 flexible hinge region; other site 1294143001710 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1294143001711 putative switch regulator; other site 1294143001712 non-specific DNA interactions [nucleotide binding]; other site 1294143001713 DNA binding site [nucleotide binding] 1294143001714 sequence specific DNA binding site [nucleotide binding]; other site 1294143001715 putative cAMP binding site [chemical binding]; other site 1294143001716 OsmC-like protein; Region: OsmC; cl00767 1294143001717 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1294143001718 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1294143001719 diiron binding motif [ion binding]; other site 1294143001720 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1294143001721 nucleotide binding site/active site [active] 1294143001722 HIT family signature motif; other site 1294143001723 catalytic residue [active] 1294143001724 Ycf46; Provisional; Region: ycf46; CHL00195 1294143001725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143001726 ATP binding site [chemical binding]; other site 1294143001727 Walker B motif; other site 1294143001728 arginine finger; other site 1294143001729 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1294143001730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143001731 NAD(P) binding site [chemical binding]; other site 1294143001732 active site 1294143001733 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1294143001734 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1294143001735 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1294143001736 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1294143001737 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1294143001738 FMN binding site [chemical binding]; other site 1294143001739 substrate binding site [chemical binding]; other site 1294143001740 putative catalytic residue [active] 1294143001741 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1294143001742 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1294143001743 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1294143001744 putative ion selectivity filter; other site 1294143001745 putative pore gating glutamate residue; other site 1294143001746 putative H+/Cl- coupling transport residue; other site 1294143001747 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1294143001748 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1294143001749 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1294143001750 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1294143001751 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1294143001752 putative peptidase; Provisional; Region: PRK11649 1294143001753 Peptidase family M23; Region: Peptidase_M23; pfam01551 1294143001754 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1294143001755 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1294143001756 active site 1294143001757 HIGH motif; other site 1294143001758 dimer interface [polypeptide binding]; other site 1294143001759 KMSKS motif; other site 1294143001760 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1294143001761 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1294143001762 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1294143001763 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1294143001764 pantothenate kinase; Reviewed; Region: PRK13322 1294143001765 Sporulation related domain; Region: SPOR; cl10051 1294143001766 elongation factor Tu; Reviewed; Region: PRK00049 1294143001767 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1294143001768 G1 box; other site 1294143001769 GEF interaction site [polypeptide binding]; other site 1294143001770 GTP/Mg2+ binding site [chemical binding]; other site 1294143001771 Switch I region; other site 1294143001772 G2 box; other site 1294143001773 G3 box; other site 1294143001774 Switch II region; other site 1294143001775 G4 box; other site 1294143001776 G5 box; other site 1294143001777 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1294143001778 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1294143001779 Antibiotic Binding Site [chemical binding]; other site 1294143001780 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1294143001781 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1294143001782 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1294143001783 putative homodimer interface [polypeptide binding]; other site 1294143001784 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1294143001785 heterodimer interface [polypeptide binding]; other site 1294143001786 homodimer interface [polypeptide binding]; other site 1294143001787 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1294143001788 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1294143001789 23S rRNA interface [nucleotide binding]; other site 1294143001790 L7/L12 interface [polypeptide binding]; other site 1294143001791 putative thiostrepton binding site; other site 1294143001792 L25 interface [polypeptide binding]; other site 1294143001793 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1294143001794 mRNA/rRNA interface [nucleotide binding]; other site 1294143001795 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1294143001796 23S rRNA interface [nucleotide binding]; other site 1294143001797 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1294143001798 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1294143001799 core dimer interface [polypeptide binding]; other site 1294143001800 peripheral dimer interface [polypeptide binding]; other site 1294143001801 L10 interface [polypeptide binding]; other site 1294143001802 L11 interface [polypeptide binding]; other site 1294143001803 putative EF-Tu interaction site [polypeptide binding]; other site 1294143001804 putative EF-G interaction site [polypeptide binding]; other site 1294143001805 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1294143001806 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1294143001807 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1294143001808 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1294143001809 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1294143001810 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1294143001811 RPB3 interaction site [polypeptide binding]; other site 1294143001812 RPB1 interaction site [polypeptide binding]; other site 1294143001813 RPB11 interaction site [polypeptide binding]; other site 1294143001814 RPB10 interaction site [polypeptide binding]; other site 1294143001815 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1294143001816 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1294143001817 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1294143001818 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1294143001819 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1294143001820 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1294143001821 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1294143001822 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1294143001823 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1294143001824 DNA binding site [nucleotide binding] 1294143001825 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1294143001826 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1294143001827 S17 interaction site [polypeptide binding]; other site 1294143001828 S8 interaction site; other site 1294143001829 16S rRNA interaction site [nucleotide binding]; other site 1294143001830 streptomycin interaction site [chemical binding]; other site 1294143001831 23S rRNA interaction site [nucleotide binding]; other site 1294143001832 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1294143001833 30S ribosomal protein S7; Validated; Region: PRK05302 1294143001834 elongation factor G; Reviewed; Region: PRK00007 1294143001835 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1294143001836 G1 box; other site 1294143001837 putative GEF interaction site [polypeptide binding]; other site 1294143001838 GTP/Mg2+ binding site [chemical binding]; other site 1294143001839 Switch I region; other site 1294143001840 G2 box; other site 1294143001841 G3 box; other site 1294143001842 Switch II region; other site 1294143001843 G4 box; other site 1294143001844 G5 box; other site 1294143001845 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1294143001846 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1294143001847 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1294143001848 elongation factor Tu; Reviewed; Region: PRK00049 1294143001849 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1294143001850 G1 box; other site 1294143001851 GEF interaction site [polypeptide binding]; other site 1294143001852 GTP/Mg2+ binding site [chemical binding]; other site 1294143001853 Switch I region; other site 1294143001854 G2 box; other site 1294143001855 G3 box; other site 1294143001856 Switch II region; other site 1294143001857 G4 box; other site 1294143001858 G5 box; other site 1294143001859 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1294143001860 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1294143001861 Antibiotic Binding Site [chemical binding]; other site 1294143001862 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1294143001863 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1294143001864 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1294143001865 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1294143001866 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1294143001867 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1294143001868 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1294143001869 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1294143001870 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1294143001871 protein-rRNA interface [nucleotide binding]; other site 1294143001872 putative translocon binding site; other site 1294143001873 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1294143001874 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1294143001875 G-X-X-G motif; other site 1294143001876 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1294143001877 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1294143001878 23S rRNA interface [nucleotide binding]; other site 1294143001879 5S rRNA interface [nucleotide binding]; other site 1294143001880 putative antibiotic binding site [chemical binding]; other site 1294143001881 L25 interface [polypeptide binding]; other site 1294143001882 L27 interface [polypeptide binding]; other site 1294143001883 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1294143001884 23S rRNA interface [nucleotide binding]; other site 1294143001885 putative translocon interaction site; other site 1294143001886 signal recognition particle (SRP54) interaction site; other site 1294143001887 L23 interface [polypeptide binding]; other site 1294143001888 trigger factor interaction site; other site 1294143001889 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1294143001890 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1294143001891 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1294143001892 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1294143001893 RNA binding site [nucleotide binding]; other site 1294143001894 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1294143001895 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1294143001896 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1294143001897 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1294143001898 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1294143001899 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1294143001900 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1294143001901 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1294143001902 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1294143001903 5S rRNA interface [nucleotide binding]; other site 1294143001904 23S rRNA interface [nucleotide binding]; other site 1294143001905 L5 interface [polypeptide binding]; other site 1294143001906 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1294143001907 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1294143001908 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1294143001909 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1294143001910 23S rRNA binding site [nucleotide binding]; other site 1294143001911 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1294143001912 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1294143001913 SecY translocase; Region: SecY; pfam00344 1294143001914 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1294143001915 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1294143001916 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1294143001917 30S ribosomal protein S11; Validated; Region: PRK05309 1294143001918 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1294143001919 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1294143001920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1294143001921 RNA binding surface [nucleotide binding]; other site 1294143001922 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1294143001923 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1294143001924 alphaNTD homodimer interface [polypeptide binding]; other site 1294143001925 alphaNTD - beta interaction site [polypeptide binding]; other site 1294143001926 alphaNTD - beta' interaction site [polypeptide binding]; other site 1294143001927 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1294143001928 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1294143001929 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1294143001930 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1294143001931 tetramer interface [polypeptide binding]; other site 1294143001932 heme binding pocket [chemical binding]; other site 1294143001933 NADPH binding site [chemical binding]; other site 1294143001934 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1294143001935 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1294143001936 heme binding site [chemical binding]; other site 1294143001937 ferroxidase pore; other site 1294143001938 ferroxidase diiron center [ion binding]; other site 1294143001939 Integrase core domain; Region: rve; pfam00665 1294143001940 Integrase core domain; Region: rve_3; pfam13683 1294143001941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1294143001942 Homeodomain-like domain; Region: HTH_23; cl17451 1294143001943 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1294143001944 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1294143001945 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1294143001946 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1294143001947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143001948 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143001949 putative substrate translocation pore; other site 1294143001950 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1294143001951 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1294143001952 dimer interface [polypeptide binding]; other site 1294143001953 ssDNA binding site [nucleotide binding]; other site 1294143001954 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1294143001955 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1294143001956 DNA binding site [nucleotide binding] 1294143001957 Int/Topo IB signature motif; other site 1294143001958 active site 1294143001959 catalytic residues [active] 1294143001960 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1294143001961 active site 1294143001962 catalytic residues [active] 1294143001963 DNA binding site [nucleotide binding] 1294143001964 Int/Topo IB signature motif; other site 1294143001965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1294143001966 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1294143001967 DNA binding site [nucleotide binding] 1294143001968 active site 1294143001969 Int/Topo IB signature motif; other site 1294143001970 catalytic residues [active] 1294143001971 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1294143001972 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1294143001973 cofactor binding site; other site 1294143001974 DNA binding site [nucleotide binding] 1294143001975 substrate interaction site [chemical binding]; other site 1294143001976 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1294143001977 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1294143001978 additional DNA contacts [nucleotide binding]; other site 1294143001979 mismatch recognition site; other site 1294143001980 active site 1294143001981 zinc binding site [ion binding]; other site 1294143001982 DNA intercalation site [nucleotide binding]; other site 1294143001983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143001984 putative substrate translocation pore; other site 1294143001985 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1294143001986 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1294143001987 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1294143001988 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1294143001989 active site 1294143001990 SAM binding site [chemical binding]; other site 1294143001991 homodimer interface [polypeptide binding]; other site 1294143001992 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1294143001993 active site 1294143001994 SAM binding site [chemical binding]; other site 1294143001995 homodimer interface [polypeptide binding]; other site 1294143001996 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1294143001997 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1294143001998 precorrin-3B synthase; Region: CobG; TIGR02435 1294143001999 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1294143002000 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1294143002001 active site 1294143002002 putative homodimer interface [polypeptide binding]; other site 1294143002003 SAM binding site [chemical binding]; other site 1294143002004 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1294143002005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143002006 S-adenosylmethionine binding site [chemical binding]; other site 1294143002007 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1294143002008 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1294143002009 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1294143002010 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143002011 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1294143002012 putative C-terminal domain interface [polypeptide binding]; other site 1294143002013 putative GSH binding site (G-site) [chemical binding]; other site 1294143002014 putative dimer interface [polypeptide binding]; other site 1294143002015 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1294143002016 putative N-terminal domain interface [polypeptide binding]; other site 1294143002017 putative dimer interface [polypeptide binding]; other site 1294143002018 putative substrate binding pocket (H-site) [chemical binding]; other site 1294143002019 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1294143002020 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1294143002021 metal ion-dependent adhesion site (MIDAS); other site 1294143002022 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1294143002023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143002024 Walker A motif; other site 1294143002025 ATP binding site [chemical binding]; other site 1294143002026 Walker B motif; other site 1294143002027 arginine finger; other site 1294143002028 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1294143002029 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1294143002030 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1294143002031 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1294143002032 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1294143002033 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1294143002034 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1294143002035 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1294143002036 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 1294143002037 Predicted integral membrane protein [Function unknown]; Region: COG5446 1294143002038 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1294143002039 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1294143002040 active site 1294143002041 SAM binding site [chemical binding]; other site 1294143002042 homodimer interface [polypeptide binding]; other site 1294143002043 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143002044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143002045 DNA-binding site [nucleotide binding]; DNA binding site 1294143002046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143002047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143002048 homodimer interface [polypeptide binding]; other site 1294143002049 catalytic residue [active] 1294143002050 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1294143002051 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1294143002052 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1294143002053 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1294143002054 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1294143002055 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1294143002056 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1294143002057 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1294143002058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143002059 NAD(P) binding site [chemical binding]; other site 1294143002060 active site 1294143002061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143002062 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1294143002063 NAD(P) binding site [chemical binding]; other site 1294143002064 active site 1294143002065 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 1294143002066 OmpW family; Region: OmpW; cl17427 1294143002067 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1294143002068 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1294143002069 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1294143002070 FtsX-like permease family; Region: FtsX; pfam02687 1294143002071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1294143002072 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1294143002073 Walker A/P-loop; other site 1294143002074 ATP binding site [chemical binding]; other site 1294143002075 Q-loop/lid; other site 1294143002076 ABC transporter signature motif; other site 1294143002077 Walker B; other site 1294143002078 D-loop; other site 1294143002079 H-loop/switch region; other site 1294143002080 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1294143002081 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1294143002082 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1294143002083 Predicted methyltransferase [General function prediction only]; Region: COG3897 1294143002084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143002085 S-adenosylmethionine binding site [chemical binding]; other site 1294143002086 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1294143002087 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1294143002088 ATP cone domain; Region: ATP-cone; pfam03477 1294143002089 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1294143002090 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1294143002091 catalytic motif [active] 1294143002092 Zn binding site [ion binding]; other site 1294143002093 RibD C-terminal domain; Region: RibD_C; cl17279 1294143002094 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1294143002095 Lumazine binding domain; Region: Lum_binding; pfam00677 1294143002096 Lumazine binding domain; Region: Lum_binding; pfam00677 1294143002097 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1294143002098 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1294143002099 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1294143002100 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1294143002101 homopentamer interface [polypeptide binding]; other site 1294143002102 active site 1294143002103 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1294143002104 putative RNA binding site [nucleotide binding]; other site 1294143002105 thiamine monophosphate kinase; Provisional; Region: PRK05731 1294143002106 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1294143002107 ATP binding site [chemical binding]; other site 1294143002108 dimerization interface [polypeptide binding]; other site 1294143002109 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1294143002110 tetramer interfaces [polypeptide binding]; other site 1294143002111 binuclear metal-binding site [ion binding]; other site 1294143002112 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143002113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143002114 membrane-bound complex binding site; other site 1294143002115 hinge residues; other site 1294143002116 Predicted aspartyl protease [General function prediction only]; Region: COG3577 1294143002117 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1294143002118 catalytic motif [active] 1294143002119 Catalytic residue [active] 1294143002120 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1294143002121 dimerization interface [polypeptide binding]; other site 1294143002122 active site 1294143002123 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1294143002124 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1294143002125 cobalamin binding residues [chemical binding]; other site 1294143002126 putative BtuC binding residues; other site 1294143002127 dimer interface [polypeptide binding]; other site 1294143002128 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1294143002129 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1294143002130 putative NAD(P) binding site [chemical binding]; other site 1294143002131 dimer interface [polypeptide binding]; other site 1294143002132 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1294143002133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143002134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143002135 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143002136 putative effector binding pocket; other site 1294143002137 dimerization interface [polypeptide binding]; other site 1294143002138 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1294143002139 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1294143002140 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1294143002141 active site 1294143002142 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1294143002143 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1294143002144 active site 1294143002145 DNA binding site [nucleotide binding] 1294143002146 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1294143002147 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1294143002148 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1294143002149 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1294143002150 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1294143002151 putative catalytic cysteine [active] 1294143002152 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1294143002153 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1294143002154 active site 1294143002155 (T/H)XGH motif; other site 1294143002156 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1294143002157 Uncharacterized conserved protein [Function unknown]; Region: COG1576 1294143002158 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1294143002159 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1294143002160 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1294143002161 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1294143002162 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1294143002163 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143002164 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143002165 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1294143002166 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1294143002167 Sporulation related domain; Region: SPOR; pfam05036 1294143002168 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1294143002169 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1294143002170 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1294143002171 Protein of unknown function (DUF493); Region: DUF493; cl01102 1294143002172 lipoate-protein ligase B; Provisional; Region: PRK14342 1294143002173 lipoyl synthase; Provisional; Region: PRK05481 1294143002174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143002175 FeS/SAM binding site; other site 1294143002176 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1294143002177 putative chaperone protein EcpD; Provisional; Region: PRK09926 1294143002178 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1294143002179 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1294143002180 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1294143002181 PapC N-terminal domain; Region: PapC_N; pfam13954 1294143002182 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1294143002183 PapC C-terminal domain; Region: PapC_C; pfam13953 1294143002184 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1294143002185 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1294143002186 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143002187 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143002188 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1294143002189 Domain of unknown function; Region: DUF331; cl01149 1294143002190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1294143002191 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1294143002192 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1294143002193 Lipopolysaccharide-assembly; Region: LptE; cl01125 1294143002194 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1294143002195 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1294143002196 HIGH motif; other site 1294143002197 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1294143002198 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1294143002199 active site 1294143002200 KMSKS motif; other site 1294143002201 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1294143002202 tRNA binding surface [nucleotide binding]; other site 1294143002203 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1294143002204 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1294143002205 putative active site [active] 1294143002206 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1294143002207 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1294143002208 putative active site [active] 1294143002209 catalytic triad [active] 1294143002210 putative dimer interface [polypeptide binding]; other site 1294143002211 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1294143002212 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1294143002213 Transporter associated domain; Region: CorC_HlyC; smart01091 1294143002214 metal-binding heat shock protein; Provisional; Region: PRK00016 1294143002215 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1294143002216 PhoH-like protein; Region: PhoH; pfam02562 1294143002217 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1294143002218 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1294143002219 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143002220 FeS/SAM binding site; other site 1294143002221 TRAM domain; Region: TRAM; pfam01938 1294143002222 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1294143002223 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1294143002224 Sel1-like repeats; Region: SEL1; smart00671 1294143002225 Sel1-like repeats; Region: SEL1; smart00671 1294143002226 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1294143002227 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143002228 inhibitor-cofactor binding pocket; inhibition site 1294143002229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143002230 catalytic residue [active] 1294143002231 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1294143002232 thiamine phosphate binding site [chemical binding]; other site 1294143002233 active site 1294143002234 pyrophosphate binding site [ion binding]; other site 1294143002235 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1294143002236 dimer interface [polypeptide binding]; other site 1294143002237 substrate binding site [chemical binding]; other site 1294143002238 ATP binding site [chemical binding]; other site 1294143002239 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1294143002240 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1294143002241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143002242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143002243 dimer interface [polypeptide binding]; other site 1294143002244 phosphorylation site [posttranslational modification] 1294143002245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143002246 ATP binding site [chemical binding]; other site 1294143002247 Mg2+ binding site [ion binding]; other site 1294143002248 G-X-G motif; other site 1294143002249 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143002250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143002251 active site 1294143002252 phosphorylation site [posttranslational modification] 1294143002253 intermolecular recognition site; other site 1294143002254 dimerization interface [polypeptide binding]; other site 1294143002255 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1294143002256 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1294143002257 homodimer interface [polypeptide binding]; other site 1294143002258 substrate-cofactor binding pocket; other site 1294143002259 catalytic residue [active] 1294143002260 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1294143002261 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1294143002262 Bacterial transcriptional regulator; Region: IclR; pfam01614 1294143002263 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1294143002264 DUF35 OB-fold domain; Region: DUF35; pfam01796 1294143002265 thiolase; Provisional; Region: PRK06158 1294143002266 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1294143002267 active site 1294143002268 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1294143002269 CoA binding domain; Region: CoA_binding_2; pfam13380 1294143002270 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1294143002271 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1294143002272 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1294143002273 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1294143002274 dimer interaction site [polypeptide binding]; other site 1294143002275 substrate-binding tunnel; other site 1294143002276 active site 1294143002277 catalytic site [active] 1294143002278 substrate binding site [chemical binding]; other site 1294143002279 benzoate transport; Region: 2A0115; TIGR00895 1294143002280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143002281 putative substrate translocation pore; other site 1294143002282 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143002283 CoenzymeA binding site [chemical binding]; other site 1294143002284 subunit interaction site [polypeptide binding]; other site 1294143002285 PHB binding site; other site 1294143002286 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143002287 active site 1294143002288 enoyl-CoA hydratase; Provisional; Region: PRK06688 1294143002289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143002290 substrate binding site [chemical binding]; other site 1294143002291 oxyanion hole (OAH) forming residues; other site 1294143002292 trimer interface [polypeptide binding]; other site 1294143002293 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1294143002294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143002295 active site 1294143002296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143002297 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 1294143002298 NAD(P) binding site [chemical binding]; other site 1294143002299 active site 1294143002300 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1294143002301 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1294143002302 FMN binding site [chemical binding]; other site 1294143002303 substrate binding site [chemical binding]; other site 1294143002304 putative catalytic residue [active] 1294143002305 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143002306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143002307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143002308 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1294143002309 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143002310 active site 1294143002311 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1294143002312 HicB family; Region: HicB; pfam05534 1294143002313 AMP nucleosidase; Provisional; Region: PRK08292 1294143002314 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1294143002315 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1294143002316 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1294143002317 intersubunit interface [polypeptide binding]; other site 1294143002318 active site 1294143002319 catalytic residue [active] 1294143002320 SEC-C motif; Region: SEC-C; pfam02810 1294143002321 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1294143002322 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1294143002323 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1294143002324 pseudouridine synthase; Region: TIGR00093 1294143002325 active site 1294143002326 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1294143002327 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143002328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143002329 putative DNA binding site [nucleotide binding]; other site 1294143002330 putative Zn2+ binding site [ion binding]; other site 1294143002331 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143002332 Cation efflux family; Region: Cation_efflux; cl00316 1294143002333 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1294143002334 DinB family; Region: DinB; cl17821 1294143002335 DinB superfamily; Region: DinB_2; pfam12867 1294143002336 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1294143002337 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1294143002338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143002339 ATP binding site [chemical binding]; other site 1294143002340 putative Mg++ binding site [ion binding]; other site 1294143002341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143002342 nucleotide binding region [chemical binding]; other site 1294143002343 ATP-binding site [chemical binding]; other site 1294143002344 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1294143002345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143002346 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1294143002347 putative metal binding site [ion binding]; other site 1294143002348 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1294143002349 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1294143002350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143002351 short chain dehydrogenase; Provisional; Region: PRK06181 1294143002352 NAD(P) binding site [chemical binding]; other site 1294143002353 active site 1294143002354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1294143002355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143002356 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1294143002357 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1294143002358 LabA_like proteins; Region: LabA; cd10911 1294143002359 putative metal binding site [ion binding]; other site 1294143002360 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1294143002361 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1294143002362 ATP binding site [chemical binding]; other site 1294143002363 Mg++ binding site [ion binding]; other site 1294143002364 motif III; other site 1294143002365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143002366 nucleotide binding region [chemical binding]; other site 1294143002367 ATP-binding site [chemical binding]; other site 1294143002368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143002369 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1294143002370 Coenzyme A binding pocket [chemical binding]; other site 1294143002371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143002372 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1294143002373 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1294143002374 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1294143002375 putative active site [active] 1294143002376 Zn binding site [ion binding]; other site 1294143002377 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1294143002378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143002379 putative substrate translocation pore; other site 1294143002380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1294143002381 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1294143002382 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1294143002383 NADPH bind site [chemical binding]; other site 1294143002384 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1294143002385 putative FMN binding site [chemical binding]; other site 1294143002386 NADPH bind site [chemical binding]; other site 1294143002387 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1294143002388 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1294143002389 active site 1294143002390 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1294143002391 catalytic triad [active] 1294143002392 dimer interface [polypeptide binding]; other site 1294143002393 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1294143002394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143002395 active site 1294143002396 motif I; other site 1294143002397 motif II; other site 1294143002398 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1294143002399 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143002400 N-terminal plug; other site 1294143002401 ligand-binding site [chemical binding]; other site 1294143002402 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1294143002403 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1294143002404 TPP-binding site; other site 1294143002405 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1294143002406 PYR/PP interface [polypeptide binding]; other site 1294143002407 dimer interface [polypeptide binding]; other site 1294143002408 TPP binding site [chemical binding]; other site 1294143002409 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1294143002410 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1294143002411 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1294143002412 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1294143002413 dimer interface [polypeptide binding]; other site 1294143002414 NADP binding site [chemical binding]; other site 1294143002415 catalytic residues [active] 1294143002416 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1294143002417 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1294143002418 inhibitor site; inhibition site 1294143002419 active site 1294143002420 dimer interface [polypeptide binding]; other site 1294143002421 catalytic residue [active] 1294143002422 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1294143002423 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1294143002424 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1294143002425 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143002426 Walker A/P-loop; other site 1294143002427 ATP binding site [chemical binding]; other site 1294143002428 Q-loop/lid; other site 1294143002429 ABC transporter signature motif; other site 1294143002430 Walker B; other site 1294143002431 D-loop; other site 1294143002432 H-loop/switch region; other site 1294143002433 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143002434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143002435 dimer interface [polypeptide binding]; other site 1294143002436 conserved gate region; other site 1294143002437 putative PBP binding loops; other site 1294143002438 ABC-ATPase subunit interface; other site 1294143002439 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143002440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143002441 dimer interface [polypeptide binding]; other site 1294143002442 conserved gate region; other site 1294143002443 putative PBP binding loops; other site 1294143002444 ABC-ATPase subunit interface; other site 1294143002445 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1294143002446 substrate binding site [chemical binding]; other site 1294143002447 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1294143002448 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1294143002449 substrate binding site [chemical binding]; other site 1294143002450 ligand binding site [chemical binding]; other site 1294143002451 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143002452 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143002453 substrate binding pocket [chemical binding]; other site 1294143002454 membrane-bound complex binding site; other site 1294143002455 hinge residues; other site 1294143002456 PAS fold; Region: PAS_4; pfam08448 1294143002457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143002458 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143002459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143002460 HTH domain; Region: HTH_11; pfam08279 1294143002461 Predicted transcriptional regulator [Transcription]; Region: COG2378 1294143002462 WYL domain; Region: WYL; pfam13280 1294143002463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143002464 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1294143002465 putative dimer interface [polypeptide binding]; other site 1294143002466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1294143002467 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1294143002468 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143002469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143002470 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1294143002471 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1294143002472 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143002473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143002474 DNA-binding site [nucleotide binding]; DNA binding site 1294143002475 FCD domain; Region: FCD; pfam07729 1294143002476 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1294143002477 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1294143002478 substrate binding pocket [chemical binding]; other site 1294143002479 chain length determination region; other site 1294143002480 substrate-Mg2+ binding site; other site 1294143002481 catalytic residues [active] 1294143002482 aspartate-rich region 1; other site 1294143002483 active site lid residues [active] 1294143002484 aspartate-rich region 2; other site 1294143002485 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1294143002486 TPR repeat; Region: TPR_11; pfam13414 1294143002487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143002488 binding surface 1294143002489 TPR motif; other site 1294143002490 TPR repeat; Region: TPR_11; pfam13414 1294143002491 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1294143002492 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1294143002493 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1294143002494 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1294143002495 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1294143002496 Protein kinase domain; Region: Pkinase; pfam00069 1294143002497 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1294143002498 active site 1294143002499 ATP binding site [chemical binding]; other site 1294143002500 substrate binding site [chemical binding]; other site 1294143002501 activation loop (A-loop); other site 1294143002502 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1294143002503 active site 1294143002504 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1294143002505 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1294143002506 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1294143002507 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1294143002508 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1294143002509 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1294143002510 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 1294143002511 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1294143002512 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1294143002513 phosphopeptide binding site; other site 1294143002514 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1294143002515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143002516 Walker A motif; other site 1294143002517 ATP binding site [chemical binding]; other site 1294143002518 Walker B motif; other site 1294143002519 arginine finger; other site 1294143002520 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143002521 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1294143002522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143002523 Walker A motif; other site 1294143002524 ATP binding site [chemical binding]; other site 1294143002525 Walker B motif; other site 1294143002526 arginine finger; other site 1294143002527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143002528 Walker A motif; other site 1294143002529 ATP binding site [chemical binding]; other site 1294143002530 Walker B motif; other site 1294143002531 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1294143002532 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1294143002533 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1294143002534 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1294143002535 PAAR motif; Region: PAAR_motif; pfam05488 1294143002536 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1294143002537 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1294143002538 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1294143002539 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1294143002540 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1294143002541 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1294143002542 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1294143002543 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1294143002544 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1294143002545 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1294143002546 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1294143002547 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1294143002548 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1294143002549 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1294143002550 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1294143002551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143002552 putative substrate translocation pore; other site 1294143002553 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1294143002554 short chain dehydrogenase; Provisional; Region: PRK08628 1294143002555 classical (c) SDRs; Region: SDR_c; cd05233 1294143002556 NAD(P) binding site [chemical binding]; other site 1294143002557 active site 1294143002558 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1294143002559 Amidohydrolase; Region: Amidohydro_2; pfam04909 1294143002560 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1294143002561 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1294143002562 putative active site pocket [active] 1294143002563 metal binding site [ion binding]; metal-binding site 1294143002564 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1294143002565 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1294143002566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1294143002567 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1294143002568 NAD binding site [chemical binding]; other site 1294143002569 homotetramer interface [polypeptide binding]; other site 1294143002570 homodimer interface [polypeptide binding]; other site 1294143002571 active site 1294143002572 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1294143002573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143002574 DNA-binding site [nucleotide binding]; DNA binding site 1294143002575 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1294143002576 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1294143002577 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1294143002578 dimer interface [polypeptide binding]; other site 1294143002579 substrate binding site [chemical binding]; other site 1294143002580 metal binding sites [ion binding]; metal-binding site 1294143002581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228 1294143002582 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1294143002583 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1294143002584 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1294143002585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143002586 Coenzyme A binding pocket [chemical binding]; other site 1294143002587 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1294143002588 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1294143002589 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1294143002590 amino acid transporter; Region: 2A0306; TIGR00909 1294143002591 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143002592 SurA N-terminal domain; Region: SurA_N; pfam09312 1294143002593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143002594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143002595 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1294143002596 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1294143002597 NAD(P) binding site [chemical binding]; other site 1294143002598 catalytic residues [active] 1294143002599 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1294143002600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143002601 putative active site [active] 1294143002602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143002603 Walker A motif; other site 1294143002604 ATP binding site [chemical binding]; other site 1294143002605 Walker B motif; other site 1294143002606 arginine finger; other site 1294143002607 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143002608 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1294143002609 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1294143002610 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1294143002611 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1294143002612 aromatic acid decarboxylase; Validated; Region: PRK05920 1294143002613 Flavoprotein; Region: Flavoprotein; pfam02441 1294143002614 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5645 1294143002615 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1294143002616 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1294143002617 NAD binding site [chemical binding]; other site 1294143002618 active site 1294143002619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1294143002620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1294143002621 Peptidase C13 family; Region: Peptidase_C13; pfam01650 1294143002622 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1294143002623 putative active site [active] 1294143002624 putative catalytic site [active] 1294143002625 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1294143002626 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1294143002627 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1294143002628 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1294143002629 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1294143002630 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1294143002631 substrate binding site [chemical binding]; other site 1294143002632 ligand binding site [chemical binding]; other site 1294143002633 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1294143002634 substrate binding site [chemical binding]; other site 1294143002635 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1294143002636 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1294143002637 dimer interface [polypeptide binding]; other site 1294143002638 active site 1294143002639 citrylCoA binding site [chemical binding]; other site 1294143002640 oxalacetate/citrate binding site [chemical binding]; other site 1294143002641 coenzyme A binding site [chemical binding]; other site 1294143002642 catalytic triad [active] 1294143002643 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1294143002644 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1294143002645 tetramer interface [polypeptide binding]; other site 1294143002646 active site 1294143002647 Mg2+/Mn2+ binding site [ion binding]; other site 1294143002648 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143002649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143002650 DNA-binding site [nucleotide binding]; DNA binding site 1294143002651 FCD domain; Region: FCD; pfam07729 1294143002652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143002653 S-adenosylmethionine binding site [chemical binding]; other site 1294143002654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143002655 NAD(P) binding site [chemical binding]; other site 1294143002656 active site 1294143002657 Cupin; Region: Cupin_6; pfam12852 1294143002658 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143002659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143002660 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1294143002661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143002662 active site 1294143002663 phosphorylation site [posttranslational modification] 1294143002664 intermolecular recognition site; other site 1294143002665 dimerization interface [polypeptide binding]; other site 1294143002666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143002667 Walker A motif; other site 1294143002668 ATP binding site [chemical binding]; other site 1294143002669 Walker B motif; other site 1294143002670 arginine finger; other site 1294143002671 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143002672 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1294143002673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143002674 dimer interface [polypeptide binding]; other site 1294143002675 phosphorylation site [posttranslational modification] 1294143002676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143002677 ATP binding site [chemical binding]; other site 1294143002678 Mg2+ binding site [ion binding]; other site 1294143002679 G-X-G motif; other site 1294143002680 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1294143002681 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1294143002682 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1294143002683 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143002684 Walker A/P-loop; other site 1294143002685 ATP binding site [chemical binding]; other site 1294143002686 Q-loop/lid; other site 1294143002687 ABC transporter signature motif; other site 1294143002688 Walker B; other site 1294143002689 D-loop; other site 1294143002690 H-loop/switch region; other site 1294143002691 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143002692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143002693 dimer interface [polypeptide binding]; other site 1294143002694 conserved gate region; other site 1294143002695 putative PBP binding loops; other site 1294143002696 ABC-ATPase subunit interface; other site 1294143002697 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143002698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143002699 dimer interface [polypeptide binding]; other site 1294143002700 conserved gate region; other site 1294143002701 putative PBP binding loops; other site 1294143002702 ABC-ATPase subunit interface; other site 1294143002703 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1294143002704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143002705 substrate binding pocket [chemical binding]; other site 1294143002706 membrane-bound complex binding site; other site 1294143002707 hinge residues; other site 1294143002708 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1294143002709 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1294143002710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143002711 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1294143002712 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1294143002713 DNA binding site [nucleotide binding] 1294143002714 active site 1294143002715 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143002716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143002717 substrate binding pocket [chemical binding]; other site 1294143002718 membrane-bound complex binding site; other site 1294143002719 hinge residues; other site 1294143002720 PAS fold; Region: PAS_4; pfam08448 1294143002721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143002722 putative active site [active] 1294143002723 heme pocket [chemical binding]; other site 1294143002724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143002725 dimer interface [polypeptide binding]; other site 1294143002726 phosphorylation site [posttranslational modification] 1294143002727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143002728 ATP binding site [chemical binding]; other site 1294143002729 Mg2+ binding site [ion binding]; other site 1294143002730 G-X-G motif; other site 1294143002731 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1294143002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143002733 active site 1294143002734 phosphorylation site [posttranslational modification] 1294143002735 intermolecular recognition site; other site 1294143002736 dimerization interface [polypeptide binding]; other site 1294143002737 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1294143002738 Zn2+ binding site [ion binding]; other site 1294143002739 Mg2+ binding site [ion binding]; other site 1294143002740 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 1294143002741 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1294143002742 ATP binding site [chemical binding]; other site 1294143002743 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1294143002744 EamA-like transporter family; Region: EamA; pfam00892 1294143002745 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1294143002746 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1294143002747 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1294143002748 DNA binding residues [nucleotide binding] 1294143002749 dimer interface [polypeptide binding]; other site 1294143002750 copper binding site [ion binding]; other site 1294143002751 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1294143002752 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1294143002753 metal-binding site [ion binding] 1294143002754 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1294143002755 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1294143002756 metal-binding site [ion binding] 1294143002757 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1294143002758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143002759 motif II; other site 1294143002760 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 1294143002761 metal-binding site [ion binding] 1294143002762 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1294143002763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143002764 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1294143002765 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143002766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143002767 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143002768 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1294143002769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143002770 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1294143002771 putative substrate translocation pore; other site 1294143002772 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143002773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143002774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143002775 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1294143002776 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1294143002777 acyl-activating enzyme (AAE) consensus motif; other site 1294143002778 putative AMP binding site [chemical binding]; other site 1294143002779 putative active site [active] 1294143002780 putative CoA binding site [chemical binding]; other site 1294143002781 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1294143002782 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143002783 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1294143002784 ligand binding site [chemical binding]; other site 1294143002785 flexible hinge region; other site 1294143002786 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1294143002787 non-specific DNA interactions [nucleotide binding]; other site 1294143002788 DNA binding site [nucleotide binding] 1294143002789 sequence specific DNA binding site [nucleotide binding]; other site 1294143002790 putative cAMP binding site [chemical binding]; other site 1294143002791 Predicted metalloprotease [General function prediction only]; Region: COG2321 1294143002792 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1294143002793 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1294143002794 aminotransferase; Validated; Region: PRK08175 1294143002795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143002796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143002797 homodimer interface [polypeptide binding]; other site 1294143002798 catalytic residue [active] 1294143002799 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1294143002800 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1294143002801 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1294143002802 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1294143002803 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1294143002804 protein-export membrane protein SecD; Region: secD; TIGR01129 1294143002805 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1294143002806 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1294143002807 dimer interface [polypeptide binding]; other site 1294143002808 active site 1294143002809 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1294143002810 folate binding site [chemical binding]; other site 1294143002811 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143002812 PAS fold; Region: PAS_3; pfam08447 1294143002813 putative active site [active] 1294143002814 heme pocket [chemical binding]; other site 1294143002815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143002816 PAS domain; Region: PAS_9; pfam13426 1294143002817 putative active site [active] 1294143002818 heme pocket [chemical binding]; other site 1294143002819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143002820 PAS domain; Region: PAS_9; pfam13426 1294143002821 putative active site [active] 1294143002822 heme pocket [chemical binding]; other site 1294143002823 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143002824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143002825 metal binding site [ion binding]; metal-binding site 1294143002826 active site 1294143002827 I-site; other site 1294143002828 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143002829 potential frameshift: common BLAST hit: gi|152989118|ref|YP_001345473.1| type I restriction-modification system subunit R 1294143002830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143002831 non-specific DNA binding site [nucleotide binding]; other site 1294143002832 salt bridge; other site 1294143002833 sequence-specific DNA binding site [nucleotide binding]; other site 1294143002834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1294143002835 ATP binding site [chemical binding]; other site 1294143002836 putative Mg++ binding site [ion binding]; other site 1294143002837 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1294143002838 RES domain; Region: RES; pfam08808 1294143002839 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1294143002840 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1294143002841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143002842 AAA domain; Region: AAA_21; pfam13304 1294143002843 Walker A/P-loop; other site 1294143002844 ATP binding site [chemical binding]; other site 1294143002845 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1294143002846 putative active site [active] 1294143002847 putative metal-binding site [ion binding]; other site 1294143002848 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1294143002849 Part of AAA domain; Region: AAA_19; pfam13245 1294143002850 Family description; Region: UvrD_C_2; pfam13538 1294143002851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1294143002852 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1294143002853 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1294143002854 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1294143002855 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1294143002856 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1294143002857 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1294143002858 dimerization interface [polypeptide binding]; other site 1294143002859 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1294143002860 BCCT family transporter; Region: BCCT; cl00569 1294143002861 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 1294143002862 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1294143002863 DctM-like transporters; Region: DctM; pfam06808 1294143002864 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1294143002865 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143002866 membrane-bound complex binding site; other site 1294143002867 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1294143002868 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1294143002869 putative ion selectivity filter; other site 1294143002870 putative pore gating glutamate residue; other site 1294143002871 putative H+/Cl- coupling transport residue; other site 1294143002872 Integrase core domain; Region: rve_2; pfam13333 1294143002873 HTH-like domain; Region: HTH_21; pfam13276 1294143002874 Integrase core domain; Region: rve; pfam00665 1294143002875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1294143002876 Transposase; Region: HTH_Tnp_1; pfam01527 1294143002877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143002878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143002879 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1294143002880 putative effector binding pocket; other site 1294143002881 putative dimerization interface [polypeptide binding]; other site 1294143002882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1294143002883 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1294143002884 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1294143002885 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1294143002886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143002887 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143002888 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143002889 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143002890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143002891 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1294143002892 dimerization interface [polypeptide binding]; other site 1294143002893 substrate binding pocket [chemical binding]; other site 1294143002894 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143002895 active site 1294143002896 DNA binding site [nucleotide binding] 1294143002897 Int/Topo IB signature motif; other site 1294143002898 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143002899 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1294143002900 catalytic triad [active] 1294143002901 conserved cis-peptide bond; other site 1294143002902 Pirin-related protein [General function prediction only]; Region: COG1741 1294143002903 Pirin; Region: Pirin; pfam02678 1294143002904 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1294143002905 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1294143002906 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1294143002907 FMN binding site [chemical binding]; other site 1294143002908 active site 1294143002909 substrate binding site [chemical binding]; other site 1294143002910 catalytic residue [active] 1294143002911 LysR family transcriptional regulator; Provisional; Region: PRK14997 1294143002912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143002913 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143002914 putative effector binding pocket; other site 1294143002915 dimerization interface [polypeptide binding]; other site 1294143002916 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143002917 active site 1294143002918 Int/Topo IB signature motif; other site 1294143002919 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143002920 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1294143002921 active site 1294143002922 catalytic residues [active] 1294143002923 Int/Topo IB signature motif; other site 1294143002924 DNA binding site [nucleotide binding] 1294143002925 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1294143002926 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143002927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143002928 ABC transporter; Region: ABC_tran_2; pfam12848 1294143002929 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143002930 glutamate dehydrogenase; Provisional; Region: PRK09414 1294143002931 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1294143002932 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1294143002933 NAD(P) binding site [chemical binding]; other site 1294143002934 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1294143002935 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1294143002936 hypothetical protein; Reviewed; Region: PRK09588 1294143002937 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1294143002938 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1294143002939 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1294143002940 AAA domain; Region: AAA_32; pfam13654 1294143002941 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 1294143002942 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1294143002943 hypothetical protein; Provisional; Region: PRK05208 1294143002944 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1294143002945 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1294143002946 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1294143002947 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1294143002948 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1294143002949 substrate binding pocket [chemical binding]; other site 1294143002950 chain length determination region; other site 1294143002951 substrate-Mg2+ binding site; other site 1294143002952 catalytic residues [active] 1294143002953 aspartate-rich region 1; other site 1294143002954 active site lid residues [active] 1294143002955 aspartate-rich region 2; other site 1294143002956 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1294143002957 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1294143002958 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1294143002959 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1294143002960 GTP1/OBG; Region: GTP1_OBG; pfam01018 1294143002961 Obg GTPase; Region: Obg; cd01898 1294143002962 G1 box; other site 1294143002963 GTP/Mg2+ binding site [chemical binding]; other site 1294143002964 Switch I region; other site 1294143002965 G2 box; other site 1294143002966 G3 box; other site 1294143002967 Switch II region; other site 1294143002968 G4 box; other site 1294143002969 G5 box; other site 1294143002970 gamma-glutamyl kinase; Provisional; Region: PRK05429 1294143002971 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1294143002972 nucleotide binding site [chemical binding]; other site 1294143002973 homotetrameric interface [polypeptide binding]; other site 1294143002974 putative phosphate binding site [ion binding]; other site 1294143002975 putative allosteric binding site; other site 1294143002976 PUA domain; Region: PUA; pfam01472 1294143002977 CreA protein; Region: CreA; pfam05981 1294143002978 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1294143002979 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1294143002980 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1294143002981 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1294143002982 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1294143002983 active site 1294143002984 Riboflavin kinase; Region: Flavokinase; smart00904 1294143002985 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1294143002986 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1294143002987 active site 1294143002988 HIGH motif; other site 1294143002989 nucleotide binding site [chemical binding]; other site 1294143002990 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1294143002991 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1294143002992 active site 1294143002993 KMSKS motif; other site 1294143002994 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1294143002995 tRNA binding surface [nucleotide binding]; other site 1294143002996 anticodon binding site; other site 1294143002997 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1294143002998 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1294143002999 lipoprotein signal peptidase; Provisional; Region: PRK14787 1294143003000 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1294143003001 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1294143003002 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1294143003003 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1294143003004 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1294143003005 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1294143003006 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1294143003007 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 1294143003008 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1294143003009 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 1294143003010 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1294143003011 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1294143003012 Type II transport protein GspH; Region: GspH; pfam12019 1294143003013 Type II transport protein GspH; Region: GspH; pfam12019 1294143003014 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1294143003015 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143003016 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1294143003017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003018 active site 1294143003019 phosphorylation site [posttranslational modification] 1294143003020 intermolecular recognition site; other site 1294143003021 dimerization interface [polypeptide binding]; other site 1294143003022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143003023 Walker A motif; other site 1294143003024 ATP binding site [chemical binding]; other site 1294143003025 Walker B motif; other site 1294143003026 arginine finger; other site 1294143003027 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143003028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143003029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143003030 putative active site [active] 1294143003031 heme pocket [chemical binding]; other site 1294143003032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143003033 dimer interface [polypeptide binding]; other site 1294143003034 phosphorylation site [posttranslational modification] 1294143003035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143003036 ATP binding site [chemical binding]; other site 1294143003037 Mg2+ binding site [ion binding]; other site 1294143003038 G-X-G motif; other site 1294143003039 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1294143003040 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1294143003041 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1294143003042 RNA binding surface [nucleotide binding]; other site 1294143003043 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1294143003044 active site 1294143003045 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1294143003046 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1294143003047 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1294143003048 Clp amino terminal domain; Region: Clp_N; pfam02861 1294143003049 Clp amino terminal domain; Region: Clp_N; pfam02861 1294143003050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143003051 Walker A motif; other site 1294143003052 ATP binding site [chemical binding]; other site 1294143003053 Walker B motif; other site 1294143003054 arginine finger; other site 1294143003055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143003056 Walker A motif; other site 1294143003057 ATP binding site [chemical binding]; other site 1294143003058 Walker B motif; other site 1294143003059 arginine finger; other site 1294143003060 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1294143003061 PilZ domain; Region: PilZ; pfam07238 1294143003062 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1294143003063 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1294143003064 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143003065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1294143003066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143003067 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143003068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003069 active site 1294143003070 phosphorylation site [posttranslational modification] 1294143003071 intermolecular recognition site; other site 1294143003072 dimerization interface [polypeptide binding]; other site 1294143003073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143003074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143003075 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1294143003076 putative substrate binding pocket [chemical binding]; other site 1294143003077 putative dimerization interface [polypeptide binding]; other site 1294143003078 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143003079 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1294143003080 conserved cys residue [active] 1294143003081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143003082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143003083 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1294143003084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003085 active site 1294143003086 phosphorylation site [posttranslational modification] 1294143003087 intermolecular recognition site; other site 1294143003088 dimerization interface [polypeptide binding]; other site 1294143003089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143003090 DNA binding residues [nucleotide binding] 1294143003091 dimerization interface [polypeptide binding]; other site 1294143003092 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1294143003093 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1294143003094 active site 1294143003095 substrate binding site [chemical binding]; other site 1294143003096 activation loop (A-loop); other site 1294143003097 AAA ATPase domain; Region: AAA_16; pfam13191 1294143003098 Predicted ATPase [General function prediction only]; Region: COG3899 1294143003099 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1294143003100 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1294143003101 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1294143003102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143003103 putative active site [active] 1294143003104 heme pocket [chemical binding]; other site 1294143003105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143003106 dimer interface [polypeptide binding]; other site 1294143003107 phosphorylation site [posttranslational modification] 1294143003108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143003109 ATP binding site [chemical binding]; other site 1294143003110 Mg2+ binding site [ion binding]; other site 1294143003111 G-X-G motif; other site 1294143003112 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1294143003113 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1294143003114 DNA binding residues [nucleotide binding] 1294143003115 short chain dehydrogenase; Provisional; Region: PRK06500 1294143003116 classical (c) SDRs; Region: SDR_c; cd05233 1294143003117 NAD(P) binding site [chemical binding]; other site 1294143003118 active site 1294143003119 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1294143003120 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143003121 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1294143003122 short chain dehydrogenase; Provisional; Region: PRK06500 1294143003123 classical (c) SDRs; Region: SDR_c; cd05233 1294143003124 NAD(P) binding site [chemical binding]; other site 1294143003125 active site 1294143003126 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1294143003127 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1294143003128 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1294143003129 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1294143003130 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1294143003131 D-pathway; other site 1294143003132 Putative ubiquinol binding site [chemical binding]; other site 1294143003133 Low-spin heme (heme b) binding site [chemical binding]; other site 1294143003134 Putative water exit pathway; other site 1294143003135 Binuclear center (heme o3/CuB) [ion binding]; other site 1294143003136 K-pathway; other site 1294143003137 Putative proton exit pathway; other site 1294143003138 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1294143003139 Subunit I/III interface [polypeptide binding]; other site 1294143003140 Subunit III/IV interface [polypeptide binding]; other site 1294143003141 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1294143003142 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1294143003143 UbiA prenyltransferase family; Region: UbiA; pfam01040 1294143003144 Integrase core domain; Region: rve; pfam00665 1294143003145 Integrase core domain; Region: rve_3; pfam13683 1294143003146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1294143003147 Homeodomain-like domain; Region: HTH_23; cl17451 1294143003148 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1294143003149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143003150 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1294143003151 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 1294143003152 putative acetyltransferase; Provisional; Region: PRK03624 1294143003153 Predicted membrane protein [Function unknown]; Region: COG3235 1294143003154 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1294143003155 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1294143003156 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1294143003157 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1294143003158 CoA-binding site [chemical binding]; other site 1294143003159 ATP-binding [chemical binding]; other site 1294143003160 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1294143003161 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1294143003162 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1294143003163 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1294143003164 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1294143003165 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1294143003166 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1294143003167 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1294143003168 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1294143003169 Walker A motif; other site 1294143003170 ATP binding site [chemical binding]; other site 1294143003171 Walker B motif; other site 1294143003172 Pilin (bacterial filament); Region: Pilin; pfam00114 1294143003173 GtrA-like protein; Region: GtrA; pfam04138 1294143003174 hypothetical protein; Provisional; Region: PRK07208 1294143003175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143003176 UDP-glucose 4-epimerase; Region: PLN02240 1294143003177 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1294143003178 NAD binding site [chemical binding]; other site 1294143003179 homodimer interface [polypeptide binding]; other site 1294143003180 active site 1294143003181 substrate binding site [chemical binding]; other site 1294143003182 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1294143003183 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1294143003184 dimerization interface [polypeptide binding]; other site 1294143003185 active site 1294143003186 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1294143003187 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1294143003188 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1294143003189 amidase catalytic site [active] 1294143003190 Zn binding residues [ion binding]; other site 1294143003191 substrate binding site [chemical binding]; other site 1294143003192 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1294143003193 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1294143003194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143003195 dimerization interface [polypeptide binding]; other site 1294143003196 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143003197 dimer interface [polypeptide binding]; other site 1294143003198 putative CheW interface [polypeptide binding]; other site 1294143003199 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1294143003200 active site 1294143003201 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1294143003202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1294143003203 DNA binding site [nucleotide binding] 1294143003204 domain linker motif; other site 1294143003205 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1294143003206 dimerization interface [polypeptide binding]; other site 1294143003207 ligand binding site [chemical binding]; other site 1294143003208 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1294143003209 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1294143003210 active site 1294143003211 phosphorylation site [posttranslational modification] 1294143003212 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1294143003213 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1294143003214 dimerization domain swap beta strand [polypeptide binding]; other site 1294143003215 regulatory protein interface [polypeptide binding]; other site 1294143003216 active site 1294143003217 regulatory phosphorylation site [posttranslational modification]; other site 1294143003218 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1294143003219 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1294143003220 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1294143003221 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1294143003222 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1294143003223 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1294143003224 putative substrate binding site [chemical binding]; other site 1294143003225 putative ATP binding site [chemical binding]; other site 1294143003226 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1294143003227 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1294143003228 active site 1294143003229 P-loop; other site 1294143003230 phosphorylation site [posttranslational modification] 1294143003231 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1294143003232 active site 1294143003233 P-loop; other site 1294143003234 phosphorylation site [posttranslational modification] 1294143003235 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1294143003236 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1294143003237 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1294143003238 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1294143003239 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1294143003240 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1294143003241 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1294143003242 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1294143003243 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1294143003244 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1294143003245 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1294143003246 putative active site [active] 1294143003247 putative catalytic site [active] 1294143003248 putative Zn binding site [ion binding]; other site 1294143003249 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1294143003250 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1294143003251 active site 1294143003252 substrate binding site [chemical binding]; other site 1294143003253 cosubstrate binding site; other site 1294143003254 catalytic site [active] 1294143003255 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1294143003256 active site 1294143003257 hexamer interface [polypeptide binding]; other site 1294143003258 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1294143003259 NAD binding site [chemical binding]; other site 1294143003260 substrate binding site [chemical binding]; other site 1294143003261 active site 1294143003262 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1294143003263 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1294143003264 Ligand binding site; other site 1294143003265 Putative Catalytic site; other site 1294143003266 DXD motif; other site 1294143003267 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1294143003268 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1294143003269 inhibitor-cofactor binding pocket; inhibition site 1294143003270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143003271 catalytic residue [active] 1294143003272 aspartate aminotransferase; Provisional; Region: PRK05764 1294143003273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143003274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143003275 homodimer interface [polypeptide binding]; other site 1294143003276 catalytic residue [active] 1294143003277 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1294143003278 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143003279 Walker A/P-loop; other site 1294143003280 ATP binding site [chemical binding]; other site 1294143003281 Q-loop/lid; other site 1294143003282 ABC transporter signature motif; other site 1294143003283 Walker B; other site 1294143003284 D-loop; other site 1294143003285 H-loop/switch region; other site 1294143003286 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1294143003287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143003288 substrate binding pocket [chemical binding]; other site 1294143003289 membrane-bound complex binding site; other site 1294143003290 hinge residues; other site 1294143003291 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143003292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143003293 dimer interface [polypeptide binding]; other site 1294143003294 conserved gate region; other site 1294143003295 putative PBP binding loops; other site 1294143003296 ABC-ATPase subunit interface; other site 1294143003297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143003298 dimer interface [polypeptide binding]; other site 1294143003299 conserved gate region; other site 1294143003300 putative PBP binding loops; other site 1294143003301 ABC-ATPase subunit interface; other site 1294143003302 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1294143003303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143003304 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1294143003305 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1294143003306 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1294143003307 active site 1294143003308 Zn binding site [ion binding]; other site 1294143003309 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1294143003310 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1294143003311 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1294143003312 G1 box; other site 1294143003313 putative GEF interaction site [polypeptide binding]; other site 1294143003314 GTP/Mg2+ binding site [chemical binding]; other site 1294143003315 Switch I region; other site 1294143003316 G2 box; other site 1294143003317 G3 box; other site 1294143003318 Switch II region; other site 1294143003319 G4 box; other site 1294143003320 G5 box; other site 1294143003321 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1294143003322 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1294143003323 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1294143003324 dimer interface [polypeptide binding]; other site 1294143003325 active site 1294143003326 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1294143003327 catalytic residues [active] 1294143003328 substrate binding site [chemical binding]; other site 1294143003329 hypothetical protein; Provisional; Region: PRK10649 1294143003330 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1294143003331 Sulfatase; Region: Sulfatase; pfam00884 1294143003332 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1294143003333 Sel1-like repeats; Region: SEL1; smart00671 1294143003334 Sel1-like repeats; Region: SEL1; smart00671 1294143003335 Sel1-like repeats; Region: SEL1; smart00671 1294143003336 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1294143003337 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1294143003338 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143003339 N-terminal plug; other site 1294143003340 ligand-binding site [chemical binding]; other site 1294143003341 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1294143003342 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1294143003343 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1294143003344 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1294143003345 Flavodoxin; Region: Flavodoxin_1; pfam00258 1294143003346 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1294143003347 FAD binding pocket [chemical binding]; other site 1294143003348 FAD binding motif [chemical binding]; other site 1294143003349 catalytic residues [active] 1294143003350 NAD binding pocket [chemical binding]; other site 1294143003351 phosphate binding motif [ion binding]; other site 1294143003352 beta-alpha-beta structure motif; other site 1294143003353 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1294143003354 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1294143003355 putative active site [active] 1294143003356 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1294143003357 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1294143003358 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1294143003359 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143003360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143003361 putative DNA binding site [nucleotide binding]; other site 1294143003362 putative Zn2+ binding site [ion binding]; other site 1294143003363 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143003364 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1294143003365 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1294143003366 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1294143003367 Walker A/P-loop; other site 1294143003368 ATP binding site [chemical binding]; other site 1294143003369 Q-loop/lid; other site 1294143003370 ABC transporter signature motif; other site 1294143003371 Walker B; other site 1294143003372 D-loop; other site 1294143003373 H-loop/switch region; other site 1294143003374 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1294143003375 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1294143003376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1294143003377 Walker A/P-loop; other site 1294143003378 ATP binding site [chemical binding]; other site 1294143003379 Q-loop/lid; other site 1294143003380 ABC transporter signature motif; other site 1294143003381 Walker B; other site 1294143003382 D-loop; other site 1294143003383 H-loop/switch region; other site 1294143003384 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1294143003385 dipeptide transporter; Provisional; Region: PRK10913 1294143003386 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1294143003387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143003388 dimer interface [polypeptide binding]; other site 1294143003389 conserved gate region; other site 1294143003390 putative PBP binding loops; other site 1294143003391 ABC-ATPase subunit interface; other site 1294143003392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1294143003393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143003394 dimer interface [polypeptide binding]; other site 1294143003395 conserved gate region; other site 1294143003396 putative PBP binding loops; other site 1294143003397 ABC-ATPase subunit interface; other site 1294143003398 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1294143003399 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1294143003400 peptide binding site [polypeptide binding]; other site 1294143003401 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143003402 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1294143003403 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1294143003404 peptide binding site [polypeptide binding]; other site 1294143003405 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1294143003406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143003407 non-specific DNA binding site [nucleotide binding]; other site 1294143003408 salt bridge; other site 1294143003409 sequence-specific DNA binding site [nucleotide binding]; other site 1294143003410 Cupin domain; Region: Cupin_2; pfam07883 1294143003411 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1294143003412 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1294143003413 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1294143003414 active site 1294143003415 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1294143003416 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1294143003417 peptide binding site [polypeptide binding]; other site 1294143003418 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1294143003419 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1294143003420 peptide binding site [polypeptide binding]; other site 1294143003421 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1294143003422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143003423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143003424 ATP binding site [chemical binding]; other site 1294143003425 G-X-G motif; other site 1294143003426 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1294143003427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003428 active site 1294143003429 phosphorylation site [posttranslational modification] 1294143003430 intermolecular recognition site; other site 1294143003431 dimerization interface [polypeptide binding]; other site 1294143003432 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143003433 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1294143003434 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1294143003435 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1294143003436 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1294143003437 Peptidase family M23; Region: Peptidase_M23; pfam01551 1294143003438 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1294143003439 Predicted permeases [General function prediction only]; Region: COG0679 1294143003440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1294143003441 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1294143003442 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909 1294143003443 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 1294143003444 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1294143003445 MG2 domain; Region: A2M_N; pfam01835 1294143003446 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1294143003447 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1294143003448 Predicted secreted protein [Function unknown]; Region: COG5445 1294143003449 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1294143003450 Predicted secreted protein [Function unknown]; Region: COG5445 1294143003451 Stage II sporulation protein; Region: SpoIID; pfam08486 1294143003452 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1294143003453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1294143003454 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 1294143003455 putative metal binding site [ion binding]; other site 1294143003456 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1294143003457 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1294143003458 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1294143003459 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1294143003460 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1294143003461 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1294143003462 GatB domain; Region: GatB_Yqey; smart00845 1294143003463 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1294143003464 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1294143003465 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1294143003466 rod shape-determining protein MreB; Provisional; Region: PRK13927 1294143003467 MreB and similar proteins; Region: MreB_like; cd10225 1294143003468 nucleotide binding site [chemical binding]; other site 1294143003469 Mg binding site [ion binding]; other site 1294143003470 putative protofilament interaction site [polypeptide binding]; other site 1294143003471 RodZ interaction site [polypeptide binding]; other site 1294143003472 rod shape-determining protein MreC; Provisional; Region: PRK13922 1294143003473 rod shape-determining protein MreC; Region: MreC; pfam04085 1294143003474 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1294143003475 Maf-like protein; Region: Maf; pfam02545 1294143003476 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1294143003477 active site 1294143003478 dimer interface [polypeptide binding]; other site 1294143003479 ribonuclease G; Provisional; Region: PRK11712 1294143003480 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1294143003481 homodimer interface [polypeptide binding]; other site 1294143003482 oligonucleotide binding site [chemical binding]; other site 1294143003483 Predicted membrane protein [Function unknown]; Region: COG3164 1294143003484 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1294143003485 nitrilase; Region: PLN02798 1294143003486 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1294143003487 putative active site [active] 1294143003488 catalytic triad [active] 1294143003489 dimer interface [polypeptide binding]; other site 1294143003490 protease TldD; Provisional; Region: tldD; PRK10735 1294143003491 hypothetical protein; Provisional; Region: PRK05255 1294143003492 peptidase PmbA; Provisional; Region: PRK11040 1294143003493 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1294143003494 dimerization domain swap beta strand [polypeptide binding]; other site 1294143003495 regulatory protein interface [polypeptide binding]; other site 1294143003496 active site 1294143003497 regulatory phosphorylation site [posttranslational modification]; other site 1294143003498 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1294143003499 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1294143003500 active site 1294143003501 phosphorylation site [posttranslational modification] 1294143003502 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1294143003503 30S subunit binding site; other site 1294143003504 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1294143003505 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1294143003506 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1294143003507 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1294143003508 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1294143003509 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1294143003510 Walker A/P-loop; other site 1294143003511 ATP binding site [chemical binding]; other site 1294143003512 Q-loop/lid; other site 1294143003513 ABC transporter signature motif; other site 1294143003514 Walker B; other site 1294143003515 D-loop; other site 1294143003516 H-loop/switch region; other site 1294143003517 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1294143003518 OstA-like protein; Region: OstA; pfam03968 1294143003519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1294143003520 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1294143003521 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1294143003522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143003523 active site 1294143003524 motif I; other site 1294143003525 motif II; other site 1294143003526 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1294143003527 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1294143003528 putative active site [active] 1294143003529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1294143003530 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1294143003531 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1294143003532 Walker A/P-loop; other site 1294143003533 ATP binding site [chemical binding]; other site 1294143003534 Q-loop/lid; other site 1294143003535 ABC transporter signature motif; other site 1294143003536 Walker B; other site 1294143003537 D-loop; other site 1294143003538 H-loop/switch region; other site 1294143003539 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1294143003540 Permease; Region: Permease; cl00510 1294143003541 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1294143003542 mce related protein; Region: MCE; pfam02470 1294143003543 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1294143003544 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1294143003545 anti sigma factor interaction site; other site 1294143003546 regulatory phosphorylation site [posttranslational modification]; other site 1294143003547 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1294143003548 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1294143003549 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1294143003550 hinge; other site 1294143003551 active site 1294143003552 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1294143003553 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1294143003554 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1294143003555 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1294143003556 NAD binding site [chemical binding]; other site 1294143003557 dimerization interface [polypeptide binding]; other site 1294143003558 product binding site; other site 1294143003559 substrate binding site [chemical binding]; other site 1294143003560 zinc binding site [ion binding]; other site 1294143003561 catalytic residues [active] 1294143003562 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1294143003563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143003564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143003565 homodimer interface [polypeptide binding]; other site 1294143003566 catalytic residue [active] 1294143003567 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1294143003568 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1294143003569 protein binding site [polypeptide binding]; other site 1294143003570 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1294143003571 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1294143003572 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1294143003573 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143003574 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143003575 catalytic residue [active] 1294143003576 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1294143003577 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1294143003578 Active Sites [active] 1294143003579 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1294143003580 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1294143003581 CysD dimerization site [polypeptide binding]; other site 1294143003582 G1 box; other site 1294143003583 putative GEF interaction site [polypeptide binding]; other site 1294143003584 GTP/Mg2+ binding site [chemical binding]; other site 1294143003585 Switch I region; other site 1294143003586 G2 box; other site 1294143003587 G3 box; other site 1294143003588 Switch II region; other site 1294143003589 G4 box; other site 1294143003590 G5 box; other site 1294143003591 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1294143003592 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1294143003593 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1294143003594 ligand-binding site [chemical binding]; other site 1294143003595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1294143003596 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1294143003597 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1294143003598 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1294143003599 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1294143003600 active site 1294143003601 HIGH motif; other site 1294143003602 dimer interface [polypeptide binding]; other site 1294143003603 KMSKS motif; other site 1294143003604 Predicted ATPase [General function prediction only]; Region: COG1485 1294143003605 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143003606 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1294143003607 conserved cys residue [active] 1294143003608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143003609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143003610 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143003611 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143003612 active site 1294143003613 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1294143003614 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1294143003615 active site 1294143003616 catalytic tetrad [active] 1294143003617 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1294143003618 23S rRNA interface [nucleotide binding]; other site 1294143003619 L3 interface [polypeptide binding]; other site 1294143003620 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1294143003621 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1294143003622 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1294143003623 [2Fe-2S] cluster binding site [ion binding]; other site 1294143003624 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1294143003625 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1294143003626 Qi binding site; other site 1294143003627 intrachain domain interface; other site 1294143003628 interchain domain interface [polypeptide binding]; other site 1294143003629 heme bH binding site [chemical binding]; other site 1294143003630 heme bL binding site [chemical binding]; other site 1294143003631 Qo binding site; other site 1294143003632 interchain domain interface [polypeptide binding]; other site 1294143003633 intrachain domain interface; other site 1294143003634 Qi binding site; other site 1294143003635 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1294143003636 Qo binding site; other site 1294143003637 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 1294143003638 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1294143003639 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1294143003640 C-terminal domain interface [polypeptide binding]; other site 1294143003641 putative GSH binding site (G-site) [chemical binding]; other site 1294143003642 dimer interface [polypeptide binding]; other site 1294143003643 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1294143003644 dimer interface [polypeptide binding]; other site 1294143003645 N-terminal domain interface [polypeptide binding]; other site 1294143003646 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1294143003647 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1294143003648 BON domain; Region: BON; pfam04972 1294143003649 BON domain; Region: BON; pfam04972 1294143003650 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1294143003651 dimer interface [polypeptide binding]; other site 1294143003652 active site 1294143003653 hypothetical protein; Reviewed; Region: PRK12497 1294143003654 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1294143003655 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1294143003656 putative ligand binding site [chemical binding]; other site 1294143003657 Predicted methyltransferases [General function prediction only]; Region: COG0313 1294143003658 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1294143003659 putative SAM binding site [chemical binding]; other site 1294143003660 putative homodimer interface [polypeptide binding]; other site 1294143003661 cell division protein MraZ; Reviewed; Region: PRK00326 1294143003662 MraZ protein; Region: MraZ; pfam02381 1294143003663 MraZ protein; Region: MraZ; pfam02381 1294143003664 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1294143003665 MraW methylase family; Region: Methyltransf_5; cl17771 1294143003666 Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116 1294143003667 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1294143003668 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1294143003669 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1294143003670 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1294143003671 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1294143003672 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1294143003673 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1294143003674 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1294143003675 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1294143003676 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1294143003677 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1294143003678 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1294143003679 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1294143003680 Mg++ binding site [ion binding]; other site 1294143003681 putative catalytic motif [active] 1294143003682 putative substrate binding site [chemical binding]; other site 1294143003683 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1294143003684 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1294143003685 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1294143003686 cell division protein FtsW; Region: ftsW; TIGR02614 1294143003687 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1294143003688 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1294143003689 active site 1294143003690 homodimer interface [polypeptide binding]; other site 1294143003691 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1294143003692 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1294143003693 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1294143003694 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1294143003695 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1294143003696 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1294143003697 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143003698 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1294143003699 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1294143003700 Cell division protein FtsQ; Region: FtsQ; pfam03799 1294143003701 cell division protein FtsA; Region: ftsA; TIGR01174 1294143003702 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1294143003703 nucleotide binding site [chemical binding]; other site 1294143003704 Cell division protein FtsA; Region: FtsA; pfam14450 1294143003705 cell division protein FtsZ; Validated; Region: PRK09330 1294143003706 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1294143003707 nucleotide binding site [chemical binding]; other site 1294143003708 SulA interaction site; other site 1294143003709 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1294143003710 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1294143003711 Protein of unknown function (DUF721); Region: DUF721; cl02324 1294143003712 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1294143003713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1294143003714 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1294143003715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143003716 nucleotide binding region [chemical binding]; other site 1294143003717 ATP-binding site [chemical binding]; other site 1294143003718 SEC-C motif; Region: SEC-C; pfam02810 1294143003719 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1294143003720 heterotetramer interface [polypeptide binding]; other site 1294143003721 active site pocket [active] 1294143003722 cleavage site 1294143003723 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1294143003724 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143003725 putative C-terminal domain interface [polypeptide binding]; other site 1294143003726 putative GSH binding site (G-site) [chemical binding]; other site 1294143003727 putative dimer interface [polypeptide binding]; other site 1294143003728 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1294143003729 putative N-terminal domain interface [polypeptide binding]; other site 1294143003730 putative dimer interface [polypeptide binding]; other site 1294143003731 putative substrate binding pocket (H-site) [chemical binding]; other site 1294143003732 hypothetical protein; Provisional; Region: PRK08999 1294143003733 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1294143003734 active site 1294143003735 8-oxo-dGMP binding site [chemical binding]; other site 1294143003736 nudix motif; other site 1294143003737 metal binding site [ion binding]; metal-binding site 1294143003738 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1294143003739 thiamine phosphate binding site [chemical binding]; other site 1294143003740 active site 1294143003741 pyrophosphate binding site [ion binding]; other site 1294143003742 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1294143003743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143003744 dimerization interface [polypeptide binding]; other site 1294143003745 PAS domain; Region: PAS; smart00091 1294143003746 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1294143003747 putative active site [active] 1294143003748 heme pocket [chemical binding]; other site 1294143003749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143003750 dimer interface [polypeptide binding]; other site 1294143003751 phosphorylation site [posttranslational modification] 1294143003752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143003753 ATP binding site [chemical binding]; other site 1294143003754 Mg2+ binding site [ion binding]; other site 1294143003755 G-X-G motif; other site 1294143003756 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1294143003757 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1294143003758 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1294143003759 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1294143003760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003761 active site 1294143003762 phosphorylation site [posttranslational modification] 1294143003763 intermolecular recognition site; other site 1294143003764 dimerization interface [polypeptide binding]; other site 1294143003765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143003766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143003767 metal binding site [ion binding]; metal-binding site 1294143003768 active site 1294143003769 I-site; other site 1294143003770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1294143003771 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1294143003772 mechanosensitive channel MscS; Provisional; Region: PRK10334 1294143003773 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1294143003774 muropeptide transporter; Validated; Region: ampG; cl17669 1294143003775 muropeptide transporter; Validated; Region: ampG; cl17669 1294143003776 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1294143003777 DNA binding site [nucleotide binding] 1294143003778 active site 1294143003779 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1294143003780 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1294143003781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143003782 NAD(P) binding site [chemical binding]; other site 1294143003783 active site 1294143003784 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1294143003785 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1294143003786 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1294143003787 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1294143003788 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1294143003789 oligomerisation interface [polypeptide binding]; other site 1294143003790 mobile loop; other site 1294143003791 roof hairpin; other site 1294143003792 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1294143003793 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1294143003794 ring oligomerisation interface [polypeptide binding]; other site 1294143003795 ATP/Mg binding site [chemical binding]; other site 1294143003796 stacking interactions; other site 1294143003797 hinge regions; other site 1294143003798 chromosome condensation membrane protein; Provisional; Region: PRK14196 1294143003799 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1294143003800 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1294143003801 active site 1294143003802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1294143003803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003804 active site 1294143003805 phosphorylation site [posttranslational modification] 1294143003806 intermolecular recognition site; other site 1294143003807 dimerization interface [polypeptide binding]; other site 1294143003808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143003809 DNA binding site [nucleotide binding] 1294143003810 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1294143003811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1294143003812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143003813 dimer interface [polypeptide binding]; other site 1294143003814 phosphorylation site [posttranslational modification] 1294143003815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143003816 ATP binding site [chemical binding]; other site 1294143003817 Mg2+ binding site [ion binding]; other site 1294143003818 G-X-G motif; other site 1294143003819 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1294143003820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143003821 S-adenosylmethionine binding site [chemical binding]; other site 1294143003822 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 1294143003823 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1294143003824 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1294143003825 active site 1294143003826 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1294143003827 Cache domain; Region: Cache_1; pfam02743 1294143003828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143003829 dimerization interface [polypeptide binding]; other site 1294143003830 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143003831 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143003832 dimer interface [polypeptide binding]; other site 1294143003833 putative CheW interface [polypeptide binding]; other site 1294143003834 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1294143003835 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1294143003836 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1294143003837 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1294143003838 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1294143003839 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1294143003840 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1294143003841 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1294143003842 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1294143003843 ATP binding site [chemical binding]; other site 1294143003844 Walker A motif; other site 1294143003845 hexamer interface [polypeptide binding]; other site 1294143003846 Walker B motif; other site 1294143003847 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1294143003848 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1294143003849 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1294143003850 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1294143003851 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1294143003852 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1294143003853 Predicted membrane protein [Function unknown]; Region: COG4655 1294143003854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143003855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003856 active site 1294143003857 phosphorylation site [posttranslational modification] 1294143003858 intermolecular recognition site; other site 1294143003859 dimerization interface [polypeptide binding]; other site 1294143003860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143003861 DNA binding residues [nucleotide binding] 1294143003862 dimerization interface [polypeptide binding]; other site 1294143003863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143003864 PAS fold; Region: PAS_3; pfam08447 1294143003865 putative active site [active] 1294143003866 heme pocket [chemical binding]; other site 1294143003867 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143003868 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1294143003869 putative active site [active] 1294143003870 heme pocket [chemical binding]; other site 1294143003871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143003872 dimer interface [polypeptide binding]; other site 1294143003873 phosphorylation site [posttranslational modification] 1294143003874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143003875 ATP binding site [chemical binding]; other site 1294143003876 Mg2+ binding site [ion binding]; other site 1294143003877 G-X-G motif; other site 1294143003878 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1294143003879 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1294143003880 psiF repeat; Region: PsiF_repeat; pfam07769 1294143003881 psiF repeat; Region: PsiF_repeat; pfam07769 1294143003882 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1294143003883 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1294143003884 active site 1294143003885 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1294143003886 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1294143003887 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1294143003888 putative metal binding site [ion binding]; other site 1294143003889 putative homodimer interface [polypeptide binding]; other site 1294143003890 putative homotetramer interface [polypeptide binding]; other site 1294143003891 putative homodimer-homodimer interface [polypeptide binding]; other site 1294143003892 putative allosteric switch controlling residues; other site 1294143003893 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1294143003894 major facilitator superfamily transporter; Provisional; Region: PRK05122 1294143003895 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143003896 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1294143003897 C-terminal domain interface [polypeptide binding]; other site 1294143003898 GSH binding site (G-site) [chemical binding]; other site 1294143003899 dimer interface [polypeptide binding]; other site 1294143003900 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1294143003901 N-terminal domain interface [polypeptide binding]; other site 1294143003902 putative substrate binding pocket (H-site) [chemical binding]; other site 1294143003903 dimer interface [polypeptide binding]; other site 1294143003904 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1294143003905 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1294143003906 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1294143003907 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1294143003908 Family description; Region: UvrD_C_2; pfam13538 1294143003909 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1294143003910 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1294143003911 AAA domain; Region: AAA_30; pfam13604 1294143003912 Family description; Region: UvrD_C_2; pfam13538 1294143003913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143003914 dimer interface [polypeptide binding]; other site 1294143003915 phosphorylation site [posttranslational modification] 1294143003916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143003917 ATP binding site [chemical binding]; other site 1294143003918 Mg2+ binding site [ion binding]; other site 1294143003919 G-X-G motif; other site 1294143003920 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143003921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003922 active site 1294143003923 phosphorylation site [posttranslational modification] 1294143003924 intermolecular recognition site; other site 1294143003925 dimerization interface [polypeptide binding]; other site 1294143003926 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143003927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003928 active site 1294143003929 phosphorylation site [posttranslational modification] 1294143003930 intermolecular recognition site; other site 1294143003931 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143003932 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1294143003933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143003934 dimer interface [polypeptide binding]; other site 1294143003935 phosphorylation site [posttranslational modification] 1294143003936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143003937 ATP binding site [chemical binding]; other site 1294143003938 Mg2+ binding site [ion binding]; other site 1294143003939 G-X-G motif; other site 1294143003940 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143003941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003942 active site 1294143003943 phosphorylation site [posttranslational modification] 1294143003944 intermolecular recognition site; other site 1294143003945 dimerization interface [polypeptide binding]; other site 1294143003946 Hpt domain; Region: Hpt; pfam01627 1294143003947 putative binding surface; other site 1294143003948 active site 1294143003949 transcriptional regulator RcsB; Provisional; Region: PRK10840 1294143003950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143003951 active site 1294143003952 phosphorylation site [posttranslational modification] 1294143003953 intermolecular recognition site; other site 1294143003954 dimerization interface [polypeptide binding]; other site 1294143003955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143003956 DNA binding residues [nucleotide binding] 1294143003957 dimerization interface [polypeptide binding]; other site 1294143003958 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1294143003959 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003960 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003961 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003962 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003963 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003964 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003965 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003966 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003967 putative transposase OrfB; Reviewed; Region: PHA02517 1294143003968 HTH-like domain; Region: HTH_21; pfam13276 1294143003969 Integrase core domain; Region: rve; pfam00665 1294143003970 Integrase core domain; Region: rve_2; pfam13333 1294143003971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1294143003972 Transposase; Region: HTH_Tnp_1; pfam01527 1294143003973 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003974 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1294143003975 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1294143003976 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1294143003977 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1294143003978 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1294143003979 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1294143003980 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1294143003981 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1294143003982 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1294143003983 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1294143003984 Fimbrial protein; Region: Fimbrial; cl01416 1294143003985 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1294143003986 PapC N-terminal domain; Region: PapC_N; pfam13954 1294143003987 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1294143003988 PapC C-terminal domain; Region: PapC_C; pfam13953 1294143003989 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1294143003990 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1294143003991 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1294143003992 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1294143003993 YCII-related domain; Region: YCII; cl00999 1294143003994 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1294143003995 putative hydrophobic ligand binding site [chemical binding]; other site 1294143003996 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1294143003997 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1294143003998 SnoaL-like domain; Region: SnoaL_3; pfam13474 1294143003999 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1294143004000 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143004001 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1294143004002 DNA binding residues [nucleotide binding] 1294143004003 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1294143004004 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1294143004005 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143004006 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143004007 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1294143004008 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1294143004009 Chromate transporter; Region: Chromate_transp; pfam02417 1294143004010 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1294143004011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143004012 NAD(P) binding site [chemical binding]; other site 1294143004013 active site 1294143004014 Peptidase C26; Region: Peptidase_C26; pfam07722 1294143004015 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1294143004016 catalytic triad [active] 1294143004017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143004018 PAS fold; Region: PAS_3; pfam08447 1294143004019 putative active site [active] 1294143004020 heme pocket [chemical binding]; other site 1294143004021 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143004022 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143004023 metal binding site [ion binding]; metal-binding site 1294143004024 active site 1294143004025 I-site; other site 1294143004026 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143004027 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1294143004028 homotrimer interaction site [polypeptide binding]; other site 1294143004029 putative active site [active] 1294143004030 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1294143004031 EF-hand domain pair; Region: EF_hand_5; pfam13499 1294143004032 Ca2+ binding site [ion binding]; other site 1294143004033 hypothetical protein; Provisional; Region: PRK05409 1294143004034 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 1294143004035 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1294143004036 Predicted membrane protein [Function unknown]; Region: COG2259 1294143004037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143004038 HAMP domain; Region: HAMP; pfam00672 1294143004039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1294143004040 dimer interface [polypeptide binding]; other site 1294143004041 phosphorylation site [posttranslational modification] 1294143004042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143004043 ATP binding site [chemical binding]; other site 1294143004044 Mg2+ binding site [ion binding]; other site 1294143004045 G-X-G motif; other site 1294143004046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143004047 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1294143004048 active site 1294143004049 phosphorylation site [posttranslational modification] 1294143004050 intermolecular recognition site; other site 1294143004051 dimerization interface [polypeptide binding]; other site 1294143004052 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143004053 DNA binding site [nucleotide binding] 1294143004054 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1294143004055 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1294143004056 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1294143004057 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1294143004058 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1294143004059 catalytic residues [active] 1294143004060 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1294143004061 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1294143004062 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1294143004063 Flagellin N-methylase; Region: FliB; pfam03692 1294143004064 Predicted membrane protein [Function unknown]; Region: COG3619 1294143004065 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1294143004066 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1294143004067 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1294143004068 Cu(I) binding site [ion binding]; other site 1294143004069 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143004070 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1294143004071 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1294143004072 LysE type translocator; Region: LysE; cl00565 1294143004073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143004074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143004076 dimerization interface [polypeptide binding]; other site 1294143004077 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1294143004078 metal-binding site [ion binding] 1294143004079 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1294143004080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143004081 catalytic loop [active] 1294143004082 iron binding site [ion binding]; other site 1294143004083 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1294143004084 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1294143004085 DNA binding residues [nucleotide binding] 1294143004086 dimer interface [polypeptide binding]; other site 1294143004087 copper binding site [ion binding]; other site 1294143004088 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1294143004089 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1294143004090 metal-binding site [ion binding] 1294143004091 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1294143004092 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1294143004093 metal-binding site [ion binding] 1294143004094 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1294143004095 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1294143004096 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143004097 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143004098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143004099 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1294143004100 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1294143004101 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1294143004102 putative di-iron ligands [ion binding]; other site 1294143004103 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1294143004104 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143004105 DNA binding site [nucleotide binding] 1294143004106 active site 1294143004107 Int/Topo IB signature motif; other site 1294143004108 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1294143004109 Pirin-related protein [General function prediction only]; Region: COG1741 1294143004110 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1294143004111 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1294143004112 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1294143004113 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143004114 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143004115 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143004116 Predicted flavoprotein [General function prediction only]; Region: COG0431 1294143004117 Predicted membrane protein [Function unknown]; Region: COG2259 1294143004118 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1294143004119 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1294143004120 structural Zn binding site [ion binding]; other site 1294143004121 NAD binding site [chemical binding]; other site 1294143004122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143004123 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1294143004124 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1294143004125 NAD(P) binding site [chemical binding]; other site 1294143004126 catalytic residues [active] 1294143004127 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1294143004128 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1294143004129 NAD(P) binding site [chemical binding]; other site 1294143004130 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143004131 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1294143004132 catalytic triad [active] 1294143004133 dimer interface [polypeptide binding]; other site 1294143004134 conserved cis-peptide bond; other site 1294143004135 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1294143004136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143004137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004138 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143004139 putative effector binding pocket; other site 1294143004140 dimerization interface [polypeptide binding]; other site 1294143004141 Transposase domain (DUF772); Region: DUF772; pfam05598 1294143004142 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1294143004143 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1294143004144 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1294143004145 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1294143004146 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1294143004147 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143004148 ligand binding site [chemical binding]; other site 1294143004149 flexible hinge region; other site 1294143004150 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1294143004151 putative switch regulator; other site 1294143004152 non-specific DNA interactions [nucleotide binding]; other site 1294143004153 DNA binding site [nucleotide binding] 1294143004154 sequence specific DNA binding site [nucleotide binding]; other site 1294143004155 putative cAMP binding site [chemical binding]; other site 1294143004156 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1294143004157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1294143004158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143004159 putative PBP binding loops; other site 1294143004160 ABC-ATPase subunit interface; other site 1294143004161 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1294143004162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143004163 Walker A/P-loop; other site 1294143004164 ATP binding site [chemical binding]; other site 1294143004165 Q-loop/lid; other site 1294143004166 ABC transporter signature motif; other site 1294143004167 Walker B; other site 1294143004168 D-loop; other site 1294143004169 H-loop/switch region; other site 1294143004170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1294143004171 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1294143004172 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1294143004173 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143004174 DNA binding site [nucleotide binding] 1294143004175 active site 1294143004176 Int/Topo IB signature motif; other site 1294143004177 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1294143004178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143004179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143004180 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143004181 substrate binding pocket [chemical binding]; other site 1294143004182 membrane-bound complex binding site; other site 1294143004183 hinge residues; other site 1294143004184 Cache domain; Region: Cache_1; pfam02743 1294143004185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1294143004186 GAF domain; Region: GAF_3; pfam13492 1294143004187 HD domain; Region: HD_5; pfam13487 1294143004188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1294143004189 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1294143004190 hypothetical protein; Provisional; Region: PRK06132 1294143004191 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1294143004192 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1294143004193 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1294143004194 RNA binding surface [nucleotide binding]; other site 1294143004195 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1294143004196 active site 1294143004197 uracil binding [chemical binding]; other site 1294143004198 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1294143004199 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 1294143004200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143004201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143004203 dimerization interface [polypeptide binding]; other site 1294143004204 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1294143004205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143004206 SCP-2 sterol transfer family; Region: SCP2; cl01225 1294143004207 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1294143004208 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1294143004209 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1294143004210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143004211 dimerization interface [polypeptide binding]; other site 1294143004212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143004213 metal binding site [ion binding]; metal-binding site 1294143004214 active site 1294143004215 I-site; other site 1294143004216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143004217 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 1294143004218 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1294143004219 metal ion-dependent adhesion site (MIDAS); other site 1294143004220 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1294143004221 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1294143004222 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1294143004223 putative active site [active] 1294143004224 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143004225 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1294143004226 Walker A/P-loop; other site 1294143004227 ATP binding site [chemical binding]; other site 1294143004228 Q-loop/lid; other site 1294143004229 ABC transporter signature motif; other site 1294143004230 Walker B; other site 1294143004231 D-loop; other site 1294143004232 H-loop/switch region; other site 1294143004233 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1294143004234 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143004235 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143004236 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1294143004237 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1294143004238 NAD binding site [chemical binding]; other site 1294143004239 substrate binding site [chemical binding]; other site 1294143004240 putative active site [active] 1294143004241 Ion channel; Region: Ion_trans_2; pfam07885 1294143004242 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1294143004243 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1294143004244 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1294143004245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143004246 substrate binding site [chemical binding]; other site 1294143004247 oxyanion hole (OAH) forming residues; other site 1294143004248 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1294143004249 enoyl-CoA hydratase; Provisional; Region: PRK09076 1294143004250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143004251 substrate binding site [chemical binding]; other site 1294143004252 oxyanion hole (OAH) forming residues; other site 1294143004253 trimer interface [polypeptide binding]; other site 1294143004254 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143004255 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1294143004256 substrate binding pocket [chemical binding]; other site 1294143004257 FAD binding site [chemical binding]; other site 1294143004258 catalytic base [active] 1294143004259 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143004260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143004261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143004262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143004263 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1294143004264 ligand binding site [chemical binding]; other site 1294143004265 active site 1294143004266 UGI interface [polypeptide binding]; other site 1294143004267 catalytic site [active] 1294143004268 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1294143004269 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1294143004270 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1294143004271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1294143004272 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1294143004273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1294143004274 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143004275 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1294143004276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143004277 active site 1294143004278 phosphorylation site [posttranslational modification] 1294143004279 intermolecular recognition site; other site 1294143004280 dimerization interface [polypeptide binding]; other site 1294143004281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143004282 DNA binding site [nucleotide binding] 1294143004283 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1294143004284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143004285 dimerization interface [polypeptide binding]; other site 1294143004286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143004287 dimer interface [polypeptide binding]; other site 1294143004288 phosphorylation site [posttranslational modification] 1294143004289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143004290 ATP binding site [chemical binding]; other site 1294143004291 Mg2+ binding site [ion binding]; other site 1294143004292 G-X-G motif; other site 1294143004293 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1294143004294 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1294143004295 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1294143004296 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1294143004297 L-aspartate oxidase; Provisional; Region: PRK09077 1294143004298 L-aspartate oxidase; Provisional; Region: PRK06175 1294143004299 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1294143004300 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1294143004301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143004302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143004303 DNA binding residues [nucleotide binding] 1294143004304 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1294143004305 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1294143004306 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1294143004307 MucB/RseB family; Region: MucB_RseB; pfam03888 1294143004308 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1294143004309 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 1294143004310 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1294143004311 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1294143004312 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1294143004313 protein binding site [polypeptide binding]; other site 1294143004314 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1294143004315 protein binding site [polypeptide binding]; other site 1294143004316 GTP-binding protein LepA; Provisional; Region: PRK05433 1294143004317 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1294143004318 G1 box; other site 1294143004319 putative GEF interaction site [polypeptide binding]; other site 1294143004320 GTP/Mg2+ binding site [chemical binding]; other site 1294143004321 Switch I region; other site 1294143004322 G2 box; other site 1294143004323 G3 box; other site 1294143004324 Switch II region; other site 1294143004325 G4 box; other site 1294143004326 G5 box; other site 1294143004327 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1294143004328 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1294143004329 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1294143004330 signal peptidase I; Provisional; Region: PRK10861 1294143004331 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1294143004332 Catalytic site [active] 1294143004333 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1294143004334 ribonuclease III; Reviewed; Region: rnc; PRK00102 1294143004335 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1294143004336 dimerization interface [polypeptide binding]; other site 1294143004337 active site 1294143004338 metal binding site [ion binding]; metal-binding site 1294143004339 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1294143004340 dsRNA binding site [nucleotide binding]; other site 1294143004341 GTPase Era; Reviewed; Region: era; PRK00089 1294143004342 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1294143004343 G1 box; other site 1294143004344 GTP/Mg2+ binding site [chemical binding]; other site 1294143004345 Switch I region; other site 1294143004346 G2 box; other site 1294143004347 Switch II region; other site 1294143004348 G3 box; other site 1294143004349 G4 box; other site 1294143004350 G5 box; other site 1294143004351 Recombination protein O N terminal; Region: RecO_N; pfam11967 1294143004352 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1294143004353 Recombination protein O C terminal; Region: RecO_C; pfam02565 1294143004354 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1294143004355 active site 1294143004356 hydrophilic channel; other site 1294143004357 dimerization interface [polypeptide binding]; other site 1294143004358 catalytic residues [active] 1294143004359 active site lid [active] 1294143004360 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1294143004361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143004362 S-adenosylmethionine binding site [chemical binding]; other site 1294143004363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143004364 S-adenosylmethionine binding site [chemical binding]; other site 1294143004365 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143004366 YhhN-like protein; Region: YhhN; pfam07947 1294143004367 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 1294143004368 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1294143004369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143004370 Walker A motif; other site 1294143004371 ATP binding site [chemical binding]; other site 1294143004372 Walker B motif; other site 1294143004373 arginine finger; other site 1294143004374 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1294143004375 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143004376 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143004377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143004378 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1294143004379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143004380 Walker A motif; other site 1294143004381 ATP binding site [chemical binding]; other site 1294143004382 Walker B motif; other site 1294143004383 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1294143004384 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143004385 N-terminal plug; other site 1294143004386 ligand-binding site [chemical binding]; other site 1294143004387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143004388 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143004389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143004390 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1294143004391 Na binding site [ion binding]; other site 1294143004392 putative arabinose transporter; Provisional; Region: PRK03545 1294143004393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143004394 putative substrate translocation pore; other site 1294143004395 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143004396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143004398 dimerization interface [polypeptide binding]; other site 1294143004399 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1294143004400 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143004401 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1294143004402 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1294143004403 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1294143004404 Transglycosylase; Region: Transgly; cl17702 1294143004405 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1294143004406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143004407 S-adenosylmethionine binding site [chemical binding]; other site 1294143004408 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1294143004409 Peptidase family M48; Region: Peptidase_M48; cl12018 1294143004410 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1294143004411 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1294143004412 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143004413 catalytic triad [active] 1294143004414 conserved cis-peptide bond; other site 1294143004415 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143004416 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1294143004417 conserved cys residue [active] 1294143004418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143004419 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 1294143004420 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1294143004421 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1294143004422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143004423 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1294143004424 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143004425 N-terminal plug; other site 1294143004426 ligand-binding site [chemical binding]; other site 1294143004427 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1294143004428 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1294143004429 dimer interface [polypeptide binding]; other site 1294143004430 [2Fe-2S] cluster binding site [ion binding]; other site 1294143004431 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1294143004432 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1294143004433 intersubunit interface [polypeptide binding]; other site 1294143004434 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1294143004435 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1294143004436 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1294143004437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1294143004438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1294143004439 active site 1294143004440 catalytic tetrad [active] 1294143004441 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1294143004442 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1294143004443 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1294143004444 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 1294143004445 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1294143004446 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1294143004447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143004448 DNA binding residues [nucleotide binding] 1294143004449 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1294143004450 FecR protein; Region: FecR; pfam04773 1294143004451 Secretin and TonB N terminus short domain; Region: STN; smart00965 1294143004452 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1294143004453 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143004454 N-terminal plug; other site 1294143004455 ligand-binding site [chemical binding]; other site 1294143004456 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1294143004457 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1294143004458 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1294143004459 active site 1294143004460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1294143004461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143004462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004463 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143004464 putative effector binding pocket; other site 1294143004465 dimerization interface [polypeptide binding]; other site 1294143004466 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1294143004467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143004468 FeS/SAM binding site; other site 1294143004469 HemN C-terminal domain; Region: HemN_C; pfam06969 1294143004470 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1294143004471 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1294143004472 active site 1294143004473 FMN binding site [chemical binding]; other site 1294143004474 substrate binding site [chemical binding]; other site 1294143004475 3Fe-4S cluster binding site [ion binding]; other site 1294143004476 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1294143004477 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1294143004478 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1294143004479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143004480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143004481 DNA binding residues [nucleotide binding] 1294143004482 dimerization interface [polypeptide binding]; other site 1294143004483 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1294143004484 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1294143004485 putative active site [active] 1294143004486 catalytic triad [active] 1294143004487 putative dimer interface [polypeptide binding]; other site 1294143004488 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1294143004489 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143004490 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1294143004491 putative C-terminal domain interface [polypeptide binding]; other site 1294143004492 putative GSH binding site (G-site) [chemical binding]; other site 1294143004493 putative dimer interface [polypeptide binding]; other site 1294143004494 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1294143004495 dimer interface [polypeptide binding]; other site 1294143004496 N-terminal domain interface [polypeptide binding]; other site 1294143004497 putative substrate binding pocket (H-site) [chemical binding]; other site 1294143004498 metabolite-proton symporter; Region: 2A0106; TIGR00883 1294143004499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143004500 putative substrate translocation pore; other site 1294143004501 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1294143004502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004503 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 1294143004504 putative dimerization interface [polypeptide binding]; other site 1294143004505 putative substrate binding pocket [chemical binding]; other site 1294143004506 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143004507 active site 1294143004508 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1294143004509 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1294143004510 enoyl-CoA hydratase; Provisional; Region: PRK08138 1294143004511 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143004512 substrate binding site [chemical binding]; other site 1294143004513 oxyanion hole (OAH) forming residues; other site 1294143004514 trimer interface [polypeptide binding]; other site 1294143004515 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1294143004516 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143004517 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143004518 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143004519 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 1294143004520 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143004521 dimer interface [polypeptide binding]; other site 1294143004522 active site 1294143004523 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143004524 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1294143004525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004526 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1294143004527 putative dimerization interface [polypeptide binding]; other site 1294143004528 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1294143004529 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1294143004530 THF binding site; other site 1294143004531 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1294143004532 substrate binding site [chemical binding]; other site 1294143004533 THF binding site; other site 1294143004534 zinc-binding site [ion binding]; other site 1294143004535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1294143004536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1294143004537 GlpM protein; Region: GlpM; cl01212 1294143004538 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1294143004539 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1294143004540 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1294143004541 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1294143004542 glycerol kinase; Provisional; Region: glpK; PRK00047 1294143004543 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1294143004544 N- and C-terminal domain interface [polypeptide binding]; other site 1294143004545 active site 1294143004546 MgATP binding site [chemical binding]; other site 1294143004547 catalytic site [active] 1294143004548 metal binding site [ion binding]; metal-binding site 1294143004549 glycerol binding site [chemical binding]; other site 1294143004550 homotetramer interface [polypeptide binding]; other site 1294143004551 homodimer interface [polypeptide binding]; other site 1294143004552 FBP binding site [chemical binding]; other site 1294143004553 protein IIAGlc interface [polypeptide binding]; other site 1294143004554 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1294143004555 putative deacylase active site [active] 1294143004556 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1294143004557 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1294143004558 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1294143004559 Walker A/P-loop; other site 1294143004560 ATP binding site [chemical binding]; other site 1294143004561 Q-loop/lid; other site 1294143004562 ABC transporter signature motif; other site 1294143004563 Walker B; other site 1294143004564 D-loop; other site 1294143004565 H-loop/switch region; other site 1294143004566 TOBE domain; Region: TOBE_2; pfam08402 1294143004567 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1294143004568 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1294143004569 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1294143004570 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1294143004571 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1294143004572 putative [Fe4-S4] binding site [ion binding]; other site 1294143004573 putative molybdopterin cofactor binding site [chemical binding]; other site 1294143004574 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1294143004575 putative molybdopterin cofactor binding site; other site 1294143004576 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1294143004577 putative GSH binding site [chemical binding]; other site 1294143004578 catalytic residues [active] 1294143004579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143004580 putative substrate translocation pore; other site 1294143004581 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1294143004582 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1294143004583 heme binding site [chemical binding]; other site 1294143004584 ferroxidase pore; other site 1294143004585 ferroxidase diiron center [ion binding]; other site 1294143004586 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1294143004587 peroxidase; Provisional; Region: PRK15000 1294143004588 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1294143004589 dimer interface [polypeptide binding]; other site 1294143004590 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1294143004591 catalytic triad [active] 1294143004592 peroxidatic and resolving cysteines [active] 1294143004593 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1294143004594 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1294143004595 dimer interface [polypeptide binding]; other site 1294143004596 catalytic site [active] 1294143004597 putative active site [active] 1294143004598 putative substrate binding site [chemical binding]; other site 1294143004599 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1294143004600 active site 1294143004601 substrate binding pocket [chemical binding]; other site 1294143004602 dimer interface [polypeptide binding]; other site 1294143004603 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143004604 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143004605 ligand binding site [chemical binding]; other site 1294143004606 argininosuccinate synthase; Provisional; Region: PRK13820 1294143004607 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1294143004608 ANP binding site [chemical binding]; other site 1294143004609 Substrate Binding Site II [chemical binding]; other site 1294143004610 Substrate Binding Site I [chemical binding]; other site 1294143004611 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143004612 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1294143004613 dimer interface [polypeptide binding]; other site 1294143004614 active site 1294143004615 metal binding site [ion binding]; metal-binding site 1294143004616 glutathione binding site [chemical binding]; other site 1294143004617 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1294143004618 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1294143004619 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1294143004620 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1294143004621 minor groove reading motif; other site 1294143004622 helix-hairpin-helix signature motif; other site 1294143004623 substrate binding pocket [chemical binding]; other site 1294143004624 active site 1294143004625 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1294143004626 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1294143004627 FMN-binding domain; Region: FMN_bind; cl01081 1294143004628 electron transport complex, RnfABCDGE type, D subunit; Region: rnfD; TIGR01946 1294143004629 electron transport complex protein RnfC; Provisional; Region: PRK05035 1294143004630 SLBB domain; Region: SLBB; pfam10531 1294143004631 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1294143004632 ferredoxin; Provisional; Region: PRK08764 1294143004633 Putative Fe-S cluster; Region: FeS; pfam04060 1294143004634 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1294143004635 electron transport complex protein RsxA; Provisional; Region: PRK05151 1294143004636 CcdB protein; Region: CcdB; cl03380 1294143004637 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1294143004638 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1294143004639 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1294143004640 active site 1294143004641 HIGH motif; other site 1294143004642 KMSKS motif; other site 1294143004643 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1294143004644 tRNA binding surface [nucleotide binding]; other site 1294143004645 anticodon binding site; other site 1294143004646 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1294143004647 dimer interface [polypeptide binding]; other site 1294143004648 putative tRNA-binding site [nucleotide binding]; other site 1294143004649 antiporter inner membrane protein; Provisional; Region: PRK11670 1294143004650 Domain of unknown function DUF59; Region: DUF59; pfam01883 1294143004651 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1294143004652 Walker A motif; other site 1294143004653 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1294143004654 trimer interface [polypeptide binding]; other site 1294143004655 active site 1294143004656 Predicted ATPase [General function prediction only]; Region: COG3911 1294143004657 AAA domain; Region: AAA_28; pfam13521 1294143004658 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1294143004659 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1294143004660 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1294143004661 active site 1294143004662 SEC-C motif; Region: SEC-C; pfam02810 1294143004663 Water Stress and Hypersensitive response; Region: WHy; smart00769 1294143004664 Predicted membrane protein [Function unknown]; Region: COG2860 1294143004665 UPF0126 domain; Region: UPF0126; pfam03458 1294143004666 UPF0126 domain; Region: UPF0126; pfam03458 1294143004667 SEC-C motif; Region: SEC-C; pfam02810 1294143004668 hypothetical protein; Provisional; Region: PRK04233 1294143004669 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143004670 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143004671 ligand binding site [chemical binding]; other site 1294143004672 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 1294143004673 Predicted integral membrane protein [Function unknown]; Region: COG5615 1294143004674 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1294143004675 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1294143004676 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1294143004677 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1294143004678 Beta-lactamase; Region: Beta-lactamase; pfam00144 1294143004679 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143004680 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143004681 ligand binding site [chemical binding]; other site 1294143004682 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1294143004683 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1294143004684 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1294143004685 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1294143004686 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1294143004687 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1294143004688 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1294143004689 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1294143004690 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1294143004691 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1294143004692 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1294143004693 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1294143004694 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1294143004695 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1294143004696 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1294143004697 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1294143004698 EamA-like transporter family; Region: EamA; pfam00892 1294143004699 EamA-like transporter family; Region: EamA; pfam00892 1294143004700 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1294143004701 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1294143004702 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1294143004703 catalytic residue [active] 1294143004704 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1294143004705 aspartate racemase; Region: asp_race; TIGR00035 1294143004706 Predicted membrane protein [Function unknown]; Region: COG3650 1294143004707 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1294143004708 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1294143004709 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1294143004710 putative NAD(P) binding site [chemical binding]; other site 1294143004711 homodimer interface [polypeptide binding]; other site 1294143004712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143004713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004714 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143004715 putative effector binding pocket; other site 1294143004716 dimerization interface [polypeptide binding]; other site 1294143004717 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1294143004718 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143004719 inhibitor-cofactor binding pocket; inhibition site 1294143004720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143004721 catalytic residue [active] 1294143004722 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1294143004723 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1294143004724 active site 1294143004725 ATP binding site [chemical binding]; other site 1294143004726 substrate binding site [chemical binding]; other site 1294143004727 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143004728 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143004729 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1294143004730 classical (c) SDRs; Region: SDR_c; cd05233 1294143004731 NAD(P) binding site [chemical binding]; other site 1294143004732 active site 1294143004733 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143004734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143004735 DNA-binding site [nucleotide binding]; DNA binding site 1294143004736 FCD domain; Region: FCD; pfam07729 1294143004737 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1294143004738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1294143004739 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1294143004740 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143004741 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1294143004742 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1294143004743 active site 1294143004744 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1294143004745 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1294143004746 putative acyl-acceptor binding pocket; other site 1294143004747 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1294143004748 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1294143004749 Walker A/P-loop; other site 1294143004750 ATP binding site [chemical binding]; other site 1294143004751 Q-loop/lid; other site 1294143004752 ABC transporter signature motif; other site 1294143004753 Walker B; other site 1294143004754 D-loop; other site 1294143004755 H-loop/switch region; other site 1294143004756 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1294143004757 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1294143004758 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 1294143004759 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1294143004760 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1294143004761 DNA-binding site [nucleotide binding]; DNA binding site 1294143004762 RNA-binding motif; other site 1294143004763 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1294143004764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143004765 S-adenosylmethionine binding site [chemical binding]; other site 1294143004766 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1294143004767 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1294143004768 metal binding site [ion binding]; metal-binding site 1294143004769 dimer interface [polypeptide binding]; other site 1294143004770 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1294143004771 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1294143004772 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1294143004773 active site 1294143004774 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1294143004775 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1294143004776 putative ATP binding site [chemical binding]; other site 1294143004777 putative substrate interface [chemical binding]; other site 1294143004778 Fe-S metabolism associated domain; Region: SufE; cl00951 1294143004779 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1294143004780 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1294143004781 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1294143004782 catalytic residue [active] 1294143004783 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1294143004784 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1294143004785 putative trimer interface [polypeptide binding]; other site 1294143004786 putative CoA binding site [chemical binding]; other site 1294143004787 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1294143004788 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1294143004789 ArsC family; Region: ArsC; pfam03960 1294143004790 putative catalytic residues [active] 1294143004791 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1294143004792 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1294143004793 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143004794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143004795 homodimer interface [polypeptide binding]; other site 1294143004796 catalytic residue [active] 1294143004797 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1294143004798 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1294143004799 metal binding triad; other site 1294143004800 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1294143004801 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1294143004802 Zn2+ binding site [ion binding]; other site 1294143004803 Mg2+ binding site [ion binding]; other site 1294143004804 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1294143004805 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1294143004806 methionine aminopeptidase; Provisional; Region: PRK08671 1294143004807 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1294143004808 active site 1294143004809 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1294143004810 rRNA interaction site [nucleotide binding]; other site 1294143004811 S8 interaction site; other site 1294143004812 putative laminin-1 binding site; other site 1294143004813 elongation factor Ts; Provisional; Region: tsf; PRK09377 1294143004814 UBA/TS-N domain; Region: UBA; pfam00627 1294143004815 Elongation factor TS; Region: EF_TS; pfam00889 1294143004816 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1294143004817 putative nucleotide binding site [chemical binding]; other site 1294143004818 uridine monophosphate binding site [chemical binding]; other site 1294143004819 homohexameric interface [polypeptide binding]; other site 1294143004820 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1294143004821 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1294143004822 hinge region; other site 1294143004823 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1294143004824 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1294143004825 catalytic residue [active] 1294143004826 putative FPP diphosphate binding site; other site 1294143004827 putative FPP binding hydrophobic cleft; other site 1294143004828 dimer interface [polypeptide binding]; other site 1294143004829 putative IPP diphosphate binding site; other site 1294143004830 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1294143004831 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1294143004832 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1294143004833 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1294143004834 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1294143004835 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1294143004836 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1294143004837 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1294143004838 active site 1294143004839 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1294143004840 protein binding site [polypeptide binding]; other site 1294143004841 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1294143004842 protein binding site [polypeptide binding]; other site 1294143004843 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1294143004844 putative substrate binding region [chemical binding]; other site 1294143004845 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1294143004846 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1294143004847 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1294143004848 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1294143004849 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1294143004850 Surface antigen; Region: Bac_surface_Ag; pfam01103 1294143004851 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 1294143004852 periplasmic chaperone; Provisional; Region: PRK10780 1294143004853 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1294143004854 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1294143004855 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1294143004856 trimer interface [polypeptide binding]; other site 1294143004857 active site 1294143004858 UDP-GlcNAc binding site [chemical binding]; other site 1294143004859 lipid binding site [chemical binding]; lipid-binding site 1294143004860 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1294143004861 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1294143004862 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1294143004863 active site 1294143004864 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1294143004865 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1294143004866 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1294143004867 RNA/DNA hybrid binding site [nucleotide binding]; other site 1294143004868 active site 1294143004869 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1294143004870 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1294143004871 putative active site [active] 1294143004872 putative PHP Thumb interface [polypeptide binding]; other site 1294143004873 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1294143004874 generic binding surface II; other site 1294143004875 generic binding surface I; other site 1294143004876 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1294143004877 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1294143004878 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1294143004879 Ligand Binding Site [chemical binding]; other site 1294143004880 TilS substrate binding domain; Region: TilS; pfam09179 1294143004881 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1294143004882 CTP synthetase; Validated; Region: pyrG; PRK05380 1294143004883 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1294143004884 Catalytic site [active] 1294143004885 active site 1294143004886 UTP binding site [chemical binding]; other site 1294143004887 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1294143004888 active site 1294143004889 putative oxyanion hole; other site 1294143004890 catalytic triad [active] 1294143004891 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1294143004892 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1294143004893 enolase; Provisional; Region: eno; PRK00077 1294143004894 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1294143004895 dimer interface [polypeptide binding]; other site 1294143004896 metal binding site [ion binding]; metal-binding site 1294143004897 substrate binding pocket [chemical binding]; other site 1294143004898 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1294143004899 Septum formation initiator; Region: DivIC; cl17659 1294143004900 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1294143004901 substrate binding site; other site 1294143004902 dimer interface; other site 1294143004903 hypothetical protein; Provisional; Region: PRK11018 1294143004904 CPxP motif; other site 1294143004905 putative inner membrane protein; Provisional; Region: PRK11099 1294143004906 Sulphur transport; Region: Sulf_transp; pfam04143 1294143004907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143004908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004909 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 1294143004910 putative effector binding pocket; other site 1294143004911 putative dimerization interface [polypeptide binding]; other site 1294143004912 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1294143004913 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1294143004914 substrate binding site [chemical binding]; other site 1294143004915 catalytic Zn binding site [ion binding]; other site 1294143004916 NAD binding site [chemical binding]; other site 1294143004917 structural Zn binding site [ion binding]; other site 1294143004918 dimer interface [polypeptide binding]; other site 1294143004919 S-formylglutathione hydrolase; Region: PLN02442 1294143004920 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1294143004921 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1294143004922 homotrimer interaction site [polypeptide binding]; other site 1294143004923 zinc binding site [ion binding]; other site 1294143004924 CDP-binding sites; other site 1294143004925 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1294143004926 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1294143004927 Permutation of conserved domain; other site 1294143004928 active site 1294143004929 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1294143004930 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1294143004931 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1294143004932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143004933 S-adenosylmethionine binding site [chemical binding]; other site 1294143004934 Peptidase family M23; Region: Peptidase_M23; pfam01551 1294143004935 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1294143004936 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1294143004937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143004938 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1294143004939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143004940 DNA binding residues [nucleotide binding] 1294143004941 Ferredoxin [Energy production and conversion]; Region: COG1146 1294143004942 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1294143004943 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1294143004944 MutS domain I; Region: MutS_I; pfam01624 1294143004945 MutS domain II; Region: MutS_II; pfam05188 1294143004946 MutS domain III; Region: MutS_III; pfam05192 1294143004947 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1294143004948 Walker A/P-loop; other site 1294143004949 ATP binding site [chemical binding]; other site 1294143004950 Q-loop/lid; other site 1294143004951 ABC transporter signature motif; other site 1294143004952 Walker B; other site 1294143004953 D-loop; other site 1294143004954 H-loop/switch region; other site 1294143004955 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1294143004956 recombinase A; Provisional; Region: recA; PRK09354 1294143004957 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1294143004958 hexamer interface [polypeptide binding]; other site 1294143004959 Walker A motif; other site 1294143004960 ATP binding site [chemical binding]; other site 1294143004961 Walker B motif; other site 1294143004962 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1294143004963 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1294143004964 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1294143004965 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143004966 Beta-Casp domain; Region: Beta-Casp; smart01027 1294143004967 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1294143004968 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1294143004969 XFP N-terminal domain; Region: XFP_N; pfam09364 1294143004970 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1294143004971 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1294143004972 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1294143004973 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1294143004974 EamA-like transporter family; Region: EamA; pfam00892 1294143004975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143004976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143004977 active site 1294143004978 phosphorylation site [posttranslational modification] 1294143004979 intermolecular recognition site; other site 1294143004980 dimerization interface [polypeptide binding]; other site 1294143004981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143004982 DNA binding residues [nucleotide binding] 1294143004983 dimerization interface [polypeptide binding]; other site 1294143004984 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1294143004985 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1294143004986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143004987 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1294143004988 putative dimerization interface [polypeptide binding]; other site 1294143004989 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1294143004990 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1294143004991 FAD binding pocket [chemical binding]; other site 1294143004992 FAD binding motif [chemical binding]; other site 1294143004993 phosphate binding motif [ion binding]; other site 1294143004994 beta-alpha-beta structure motif; other site 1294143004995 NAD binding pocket [chemical binding]; other site 1294143004996 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1294143004997 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143004998 active site 1294143004999 metal binding site [ion binding]; metal-binding site 1294143005000 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1294143005001 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1294143005002 homodimer interaction site [polypeptide binding]; other site 1294143005003 cofactor binding site; other site 1294143005004 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1294143005005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1294143005006 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1294143005007 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1294143005008 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1294143005009 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1294143005010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143005011 FeS/SAM binding site; other site 1294143005012 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1294143005013 potassium uptake protein; Region: kup; TIGR00794 1294143005014 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1294143005015 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1294143005016 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1294143005017 Predicted integral membrane protein [Function unknown]; Region: COG0392 1294143005018 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1294143005019 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1294143005020 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1294143005021 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1294143005022 Autotransporter beta-domain; Region: Autotransporter; smart00869 1294143005023 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1294143005024 active site 1294143005025 DNA polymerase IV; Validated; Region: PRK02406 1294143005026 DNA binding site [nucleotide binding] 1294143005027 META domain; Region: META; pfam03724 1294143005028 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1294143005029 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1294143005030 putative ligand binding site [chemical binding]; other site 1294143005031 putative NAD binding site [chemical binding]; other site 1294143005032 catalytic site [active] 1294143005033 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1294143005034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143005035 dimerization interface [polypeptide binding]; other site 1294143005036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143005037 dimer interface [polypeptide binding]; other site 1294143005038 phosphorylation site [posttranslational modification] 1294143005039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143005040 ATP binding site [chemical binding]; other site 1294143005041 Mg2+ binding site [ion binding]; other site 1294143005042 G-X-G motif; other site 1294143005043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143005044 active site 1294143005045 phosphorylation site [posttranslational modification] 1294143005046 intermolecular recognition site; other site 1294143005047 dimerization interface [polypeptide binding]; other site 1294143005048 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143005049 putative binding surface; other site 1294143005050 active site 1294143005051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1294143005052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143005053 active site 1294143005054 phosphorylation site [posttranslational modification] 1294143005055 intermolecular recognition site; other site 1294143005056 dimerization interface [polypeptide binding]; other site 1294143005057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143005058 DNA binding site [nucleotide binding] 1294143005059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143005060 dimerization interface [polypeptide binding]; other site 1294143005061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143005062 dimer interface [polypeptide binding]; other site 1294143005063 phosphorylation site [posttranslational modification] 1294143005064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143005065 ATP binding site [chemical binding]; other site 1294143005066 Mg2+ binding site [ion binding]; other site 1294143005067 G-X-G motif; other site 1294143005068 cysteine synthase B; Region: cysM; TIGR01138 1294143005069 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1294143005070 dimer interface [polypeptide binding]; other site 1294143005071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143005072 catalytic residue [active] 1294143005073 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1294143005074 TRAM domain; Region: TRAM; pfam01938 1294143005075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1294143005076 S-adenosylmethionine binding site [chemical binding]; other site 1294143005077 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1294143005078 HD domain; Region: HD_4; pfam13328 1294143005079 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1294143005080 synthetase active site [active] 1294143005081 NTP binding site [chemical binding]; other site 1294143005082 metal binding site [ion binding]; metal-binding site 1294143005083 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1294143005084 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1294143005085 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1294143005086 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1294143005087 homodimer interface [polypeptide binding]; other site 1294143005088 metal binding site [ion binding]; metal-binding site 1294143005089 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1294143005090 homodimer interface [polypeptide binding]; other site 1294143005091 active site 1294143005092 putative chemical substrate binding site [chemical binding]; other site 1294143005093 metal binding site [ion binding]; metal-binding site 1294143005094 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1294143005095 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1294143005096 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 1294143005097 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 1294143005098 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1294143005099 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1294143005100 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1294143005101 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1294143005102 Sel1-like repeats; Region: SEL1; smart00671 1294143005103 Sel1-like repeats; Region: SEL1; smart00671 1294143005104 Sel1-like repeats; Region: SEL1; smart00671 1294143005105 Sel1-like repeats; Region: SEL1; smart00671 1294143005106 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1294143005107 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1294143005108 active site residue [active] 1294143005109 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1294143005110 active site residue [active] 1294143005111 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1294143005112 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1294143005113 putative acyl-acceptor binding pocket; other site 1294143005114 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1294143005115 Strictosidine synthase; Region: Str_synth; pfam03088 1294143005116 ribonuclease D; Region: rnd; TIGR01388 1294143005117 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1294143005118 catalytic site [active] 1294143005119 putative active site [active] 1294143005120 putative substrate binding site [chemical binding]; other site 1294143005121 HRDC domain; Region: HRDC; pfam00570 1294143005122 YcgL domain; Region: YcgL; pfam05166 1294143005123 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1294143005124 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1294143005125 NAD binding site [chemical binding]; other site 1294143005126 ligand binding site [chemical binding]; other site 1294143005127 catalytic site [active] 1294143005128 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1294143005129 putative FMN binding site [chemical binding]; other site 1294143005130 hypothetical protein; Provisional; Region: PRK05170 1294143005131 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1294143005132 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1294143005133 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1294143005134 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1294143005135 nucleotide binding site/active site [active] 1294143005136 HIT family signature motif; other site 1294143005137 catalytic residue [active] 1294143005138 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1294143005139 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1294143005140 putative active site [active] 1294143005141 putative dimer interface [polypeptide binding]; other site 1294143005142 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1294143005143 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1294143005144 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 1294143005145 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1294143005146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143005147 Coenzyme A binding pocket [chemical binding]; other site 1294143005148 EamA-like transporter family; Region: EamA; pfam00892 1294143005149 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1294143005150 EamA-like transporter family; Region: EamA; pfam00892 1294143005151 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1294143005152 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143005153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143005154 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1294143005155 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1294143005156 dimer interface [polypeptide binding]; other site 1294143005157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143005158 catalytic residue [active] 1294143005159 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1294143005160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143005161 Walker A motif; other site 1294143005162 ATP binding site [chemical binding]; other site 1294143005163 Walker B motif; other site 1294143005164 arginine finger; other site 1294143005165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1294143005166 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143005167 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143005168 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1294143005169 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1294143005170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143005171 S-adenosylmethionine binding site [chemical binding]; other site 1294143005172 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1294143005173 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1294143005174 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1294143005175 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1294143005176 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1294143005177 active site 1294143005178 Zn binding site [ion binding]; other site 1294143005179 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143005180 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143005181 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1294143005182 EamA-like transporter family; Region: EamA; pfam00892 1294143005183 EamA-like transporter family; Region: EamA; pfam00892 1294143005184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143005185 hypothetical protein; Provisional; Region: PRK07524 1294143005186 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1294143005187 PYR/PP interface [polypeptide binding]; other site 1294143005188 dimer interface [polypeptide binding]; other site 1294143005189 TPP binding site [chemical binding]; other site 1294143005190 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1294143005191 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1294143005192 TPP-binding site [chemical binding]; other site 1294143005193 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1294143005194 Na binding site [ion binding]; other site 1294143005195 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1294143005196 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1294143005197 Na binding site [ion binding]; other site 1294143005198 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1294143005199 SnoaL-like domain; Region: SnoaL_3; pfam13474 1294143005200 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1294143005201 agmatinase; Region: agmatinase; TIGR01230 1294143005202 oligomer interface [polypeptide binding]; other site 1294143005203 putative active site [active] 1294143005204 Mn binding site [ion binding]; other site 1294143005205 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143005206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143005207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143005208 dimerization interface [polypeptide binding]; other site 1294143005209 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1294143005210 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1294143005211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143005212 Walker A/P-loop; other site 1294143005213 ATP binding site [chemical binding]; other site 1294143005214 ABC transporter signature motif; other site 1294143005215 Walker B; other site 1294143005216 D-loop; other site 1294143005217 H-loop/switch region; other site 1294143005218 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143005219 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1294143005220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143005221 Coenzyme A binding pocket [chemical binding]; other site 1294143005222 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1294143005223 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1294143005224 DNA binding residues [nucleotide binding] 1294143005225 dimer interface [polypeptide binding]; other site 1294143005226 [2Fe-2S] cluster binding site [ion binding]; other site 1294143005227 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1294143005228 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143005229 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143005230 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1294143005231 putative active site [active] 1294143005232 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1294143005233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143005234 Walker A/P-loop; other site 1294143005235 ATP binding site [chemical binding]; other site 1294143005236 Q-loop/lid; other site 1294143005237 ABC transporter signature motif; other site 1294143005238 Walker B; other site 1294143005239 D-loop; other site 1294143005240 H-loop/switch region; other site 1294143005241 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1294143005242 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1294143005243 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1294143005244 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1294143005245 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1294143005246 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1294143005247 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1294143005248 metal ion-dependent adhesion site (MIDAS); other site 1294143005249 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1294143005250 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1294143005251 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143005252 dimer interface [polypeptide binding]; other site 1294143005253 active site 1294143005254 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1294143005255 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1294143005256 dimer interface [polypeptide binding]; other site 1294143005257 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1294143005258 catalytic triad [active] 1294143005259 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1294143005260 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143005261 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1294143005262 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143005263 substrate binding pocket [chemical binding]; other site 1294143005264 membrane-bound complex binding site; other site 1294143005265 hinge residues; other site 1294143005266 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1294143005267 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1294143005268 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1294143005269 active site 1294143005270 dimer interface [polypeptide binding]; other site 1294143005271 non-prolyl cis peptide bond; other site 1294143005272 insertion regions; other site 1294143005273 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1294143005274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143005275 dimer interface [polypeptide binding]; other site 1294143005276 conserved gate region; other site 1294143005277 putative PBP binding loops; other site 1294143005278 ABC-ATPase subunit interface; other site 1294143005279 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1294143005280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1294143005281 Walker A/P-loop; other site 1294143005282 ATP binding site [chemical binding]; other site 1294143005283 Q-loop/lid; other site 1294143005284 ABC transporter signature motif; other site 1294143005285 Walker B; other site 1294143005286 D-loop; other site 1294143005287 H-loop/switch region; other site 1294143005288 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1294143005289 MAPEG family; Region: MAPEG; pfam01124 1294143005290 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1294143005291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143005292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143005293 DNA binding residues [nucleotide binding] 1294143005294 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1294143005295 FecR protein; Region: FecR; pfam04773 1294143005296 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1294143005297 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143005298 N-terminal plug; other site 1294143005299 ligand-binding site [chemical binding]; other site 1294143005300 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1294143005301 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143005302 fumarate hydratase; Provisional; Region: PRK12425 1294143005303 Class II fumarases; Region: Fumarase_classII; cd01362 1294143005304 active site 1294143005305 tetramer interface [polypeptide binding]; other site 1294143005306 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 1294143005307 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1294143005308 BolA-like protein; Region: BolA; pfam01722 1294143005309 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1294143005310 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1294143005311 active site residue [active] 1294143005312 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1294143005313 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1294143005314 catalytic residues [active] 1294143005315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143005316 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1294143005317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143005318 Walker A/P-loop; other site 1294143005319 ATP binding site [chemical binding]; other site 1294143005320 Q-loop/lid; other site 1294143005321 ABC transporter signature motif; other site 1294143005322 Walker B; other site 1294143005323 D-loop; other site 1294143005324 H-loop/switch region; other site 1294143005325 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1294143005326 PAS fold; Region: PAS; pfam00989 1294143005327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143005328 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143005329 DNA binding residues [nucleotide binding] 1294143005330 dimerization interface [polypeptide binding]; other site 1294143005331 PAS fold; Region: PAS; pfam00989 1294143005332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143005333 putative active site [active] 1294143005334 heme pocket [chemical binding]; other site 1294143005335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143005336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143005337 metal binding site [ion binding]; metal-binding site 1294143005338 active site 1294143005339 I-site; other site 1294143005340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143005341 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 1294143005342 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1294143005343 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1294143005344 NAD(P) binding site [chemical binding]; other site 1294143005345 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1294143005346 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143005347 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143005348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143005349 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1294143005350 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1294143005351 dimer interface [polypeptide binding]; other site 1294143005352 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1294143005353 active site 1294143005354 Fe binding site [ion binding]; other site 1294143005355 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1294143005356 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1294143005357 C-terminal domain interface [polypeptide binding]; other site 1294143005358 GSH binding site (G-site) [chemical binding]; other site 1294143005359 putative dimer interface [polypeptide binding]; other site 1294143005360 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1294143005361 dimer interface [polypeptide binding]; other site 1294143005362 N-terminal domain interface [polypeptide binding]; other site 1294143005363 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1294143005364 aromatic amino acid transporter; Provisional; Region: PRK10238 1294143005365 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 1294143005366 Predicted periplasmic protein [General function prediction only]; Region: COG3895 1294143005367 hypothetical protein; Provisional; Region: PRK09256 1294143005368 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1294143005369 glycolate transporter; Provisional; Region: PRK09695 1294143005370 L-lactate permease; Provisional; Region: PRK10420 1294143005371 Domain of unknown function (DUF336); Region: DUF336; cl01249 1294143005372 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1294143005373 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1294143005374 Cysteine-rich domain; Region: CCG; pfam02754 1294143005375 Cysteine-rich domain; Region: CCG; pfam02754 1294143005376 FAD binding domain; Region: FAD_binding_4; pfam01565 1294143005377 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1294143005378 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1294143005379 FAD binding domain; Region: FAD_binding_4; pfam01565 1294143005380 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1294143005381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143005382 DNA-binding site [nucleotide binding]; DNA binding site 1294143005383 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1294143005384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1294143005385 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1294143005386 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1294143005387 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1294143005388 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1294143005389 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1294143005390 DNA binding residues [nucleotide binding] 1294143005391 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1294143005392 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1294143005393 putative active site [active] 1294143005394 putative FMN binding site [chemical binding]; other site 1294143005395 putative substrate binding site [chemical binding]; other site 1294143005396 putative catalytic residue [active] 1294143005397 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1294143005398 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1294143005399 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1294143005400 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143005401 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143005402 potential frameshift: common BLAST hit: gi|386058719|ref|YP_005975241.1| protein PvdQ 1294143005403 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1294143005404 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1294143005405 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1294143005406 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1294143005407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143005408 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1294143005409 putative ADP-binding pocket [chemical binding]; other site 1294143005410 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1294143005411 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1294143005412 Walker A/P-loop; other site 1294143005413 ATP binding site [chemical binding]; other site 1294143005414 Q-loop/lid; other site 1294143005415 ABC transporter signature motif; other site 1294143005416 Walker B; other site 1294143005417 D-loop; other site 1294143005418 H-loop/switch region; other site 1294143005419 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1294143005420 putative carbohydrate binding site [chemical binding]; other site 1294143005421 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1294143005422 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1294143005423 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1294143005424 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1294143005425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143005426 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1294143005427 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1294143005428 active site 1294143005429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1294143005430 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1294143005431 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1294143005432 RNA binding site [nucleotide binding]; other site 1294143005433 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1294143005434 RNA binding site [nucleotide binding]; other site 1294143005435 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1294143005436 RNA binding site [nucleotide binding]; other site 1294143005437 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1294143005438 RNA binding site [nucleotide binding]; other site 1294143005439 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1294143005440 RNA binding site [nucleotide binding]; other site 1294143005441 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1294143005442 RNA binding site [nucleotide binding]; other site 1294143005443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1294143005444 Homeodomain-like domain; Region: HTH_23; cl17451 1294143005445 Integrase core domain; Region: rve; pfam00665 1294143005446 Integrase core domain; Region: rve_3; pfam13683 1294143005447 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1294143005448 EamA-like transporter family; Region: EamA; pfam00892 1294143005449 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1294143005450 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1294143005451 NlpC/P60 family; Region: NLPC_P60; pfam00877 1294143005452 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1294143005453 nudix motif; other site 1294143005454 RibD C-terminal domain; Region: RibD_C; cl17279 1294143005455 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1294143005456 benzoate transport; Region: 2A0115; TIGR00895 1294143005457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143005458 putative substrate translocation pore; other site 1294143005459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143005460 helicase 45; Provisional; Region: PTZ00424 1294143005461 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1294143005462 ATP binding site [chemical binding]; other site 1294143005463 Mg++ binding site [ion binding]; other site 1294143005464 motif III; other site 1294143005465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143005466 nucleotide binding region [chemical binding]; other site 1294143005467 ATP-binding site [chemical binding]; other site 1294143005468 Transmembrane secretion effector; Region: MFS_3; pfam05977 1294143005469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143005470 putative substrate translocation pore; other site 1294143005471 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1294143005472 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1294143005473 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1294143005474 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1294143005475 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143005476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143005477 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143005478 putative effector binding pocket; other site 1294143005479 dimerization interface [polypeptide binding]; other site 1294143005480 acetyl-CoA synthetase; Provisional; Region: PRK00174 1294143005481 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1294143005482 active site 1294143005483 CoA binding site [chemical binding]; other site 1294143005484 acyl-activating enzyme (AAE) consensus motif; other site 1294143005485 AMP binding site [chemical binding]; other site 1294143005486 acetate binding site [chemical binding]; other site 1294143005487 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1294143005488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143005489 substrate binding pocket [chemical binding]; other site 1294143005490 membrane-bound complex binding site; other site 1294143005491 hinge residues; other site 1294143005492 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143005493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143005494 dimer interface [polypeptide binding]; other site 1294143005495 conserved gate region; other site 1294143005496 putative PBP binding loops; other site 1294143005497 ABC-ATPase subunit interface; other site 1294143005498 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143005499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143005500 dimer interface [polypeptide binding]; other site 1294143005501 conserved gate region; other site 1294143005502 putative PBP binding loops; other site 1294143005503 ABC-ATPase subunit interface; other site 1294143005504 Predicted deacylase [General function prediction only]; Region: COG3608 1294143005505 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1294143005506 active site 1294143005507 Zn binding site [ion binding]; other site 1294143005508 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1294143005509 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143005510 Walker A/P-loop; other site 1294143005511 ATP binding site [chemical binding]; other site 1294143005512 Q-loop/lid; other site 1294143005513 ABC transporter signature motif; other site 1294143005514 Walker B; other site 1294143005515 D-loop; other site 1294143005516 H-loop/switch region; other site 1294143005517 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143005518 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1294143005519 conserved cys residue [active] 1294143005520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143005521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143005522 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1294143005523 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143005524 inhibitor-cofactor binding pocket; inhibition site 1294143005525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143005526 catalytic residue [active] 1294143005527 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1294143005528 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1294143005529 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1294143005530 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1294143005531 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1294143005532 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1294143005533 NAD(P) binding site [chemical binding]; other site 1294143005534 catalytic residues [active] 1294143005535 succinylarginine dihydrolase; Provisional; Region: PRK13281 1294143005536 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1294143005537 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1294143005538 putative active site [active] 1294143005539 Zn binding site [ion binding]; other site 1294143005540 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1294143005541 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1294143005542 tetramer interface [polypeptide binding]; other site 1294143005543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143005544 catalytic residue [active] 1294143005545 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1294143005546 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1294143005547 motif 1; other site 1294143005548 active site 1294143005549 motif 2; other site 1294143005550 motif 3; other site 1294143005551 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1294143005552 DHHA1 domain; Region: DHHA1; pfam02272 1294143005553 aspartate kinase; Reviewed; Region: PRK06635 1294143005554 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1294143005555 putative nucleotide binding site [chemical binding]; other site 1294143005556 putative catalytic residues [active] 1294143005557 putative Mg ion binding site [ion binding]; other site 1294143005558 putative aspartate binding site [chemical binding]; other site 1294143005559 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1294143005560 putative allosteric regulatory site; other site 1294143005561 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1294143005562 putative allosteric regulatory residue; other site 1294143005563 carbon storage regulator; Provisional; Region: PRK01712 1294143005564 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1294143005565 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1294143005566 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1294143005567 MgtE intracellular N domain; Region: MgtE_N; smart00924 1294143005568 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1294143005569 Divalent cation transporter; Region: MgtE; cl00786 1294143005570 Arc-like DNA binding domain; Region: Arc; pfam03869 1294143005571 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1294143005572 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1294143005573 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1294143005574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143005575 Coenzyme A binding pocket [chemical binding]; other site 1294143005576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1294143005577 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1294143005578 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1294143005579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143005580 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143005581 dimerization interface [polypeptide binding]; other site 1294143005582 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1294143005583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143005584 Walker A/P-loop; other site 1294143005585 ATP binding site [chemical binding]; other site 1294143005586 Q-loop/lid; other site 1294143005587 ABC transporter signature motif; other site 1294143005588 Walker B; other site 1294143005589 D-loop; other site 1294143005590 H-loop/switch region; other site 1294143005591 TOBE domain; Region: TOBE_2; pfam08402 1294143005592 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1294143005593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143005594 dimer interface [polypeptide binding]; other site 1294143005595 conserved gate region; other site 1294143005596 putative PBP binding loops; other site 1294143005597 ABC-ATPase subunit interface; other site 1294143005598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143005599 dimer interface [polypeptide binding]; other site 1294143005600 conserved gate region; other site 1294143005601 putative PBP binding loops; other site 1294143005602 ABC-ATPase subunit interface; other site 1294143005603 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 1294143005604 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1294143005605 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1294143005606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143005607 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1294143005608 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1294143005609 Cl binding site [ion binding]; other site 1294143005610 oligomer interface [polypeptide binding]; other site 1294143005611 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1294143005612 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1294143005613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143005614 putative substrate translocation pore; other site 1294143005615 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1294143005616 PilZ domain; Region: PilZ; pfam07238 1294143005617 FlgN protein; Region: FlgN; cl09176 1294143005618 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1294143005619 SAF-like; Region: SAF_2; pfam13144 1294143005620 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1294143005621 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1294143005622 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1294143005623 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1294143005624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143005625 active site 1294143005626 phosphorylation site [posttranslational modification] 1294143005627 intermolecular recognition site; other site 1294143005628 dimerization interface [polypeptide binding]; other site 1294143005629 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1294143005630 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1294143005631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143005632 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1294143005633 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1294143005634 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1294143005635 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1294143005636 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1294143005637 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1294143005638 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1294143005639 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1294143005640 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1294143005641 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1294143005642 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1294143005643 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1294143005644 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1294143005645 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1294143005646 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1294143005647 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1294143005648 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1294143005649 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1294143005650 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1294143005651 Flagellar L-ring protein; Region: FlgH; pfam02107 1294143005652 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1294143005653 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1294143005654 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1294143005655 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 1294143005656 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1294143005657 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 1294143005658 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1294143005659 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1294143005660 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1294143005661 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1294143005662 flagellin; Provisional; Region: PRK12806 1294143005663 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1294143005664 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1294143005665 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1294143005666 FlaG protein; Region: FlaG; pfam03646 1294143005667 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1294143005668 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1294143005669 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1294143005670 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1294143005671 flagellar protein FliS; Validated; Region: fliS; PRK05685 1294143005672 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1294143005673 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1294143005674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143005675 Walker A motif; other site 1294143005676 ATP binding site [chemical binding]; other site 1294143005677 Walker B motif; other site 1294143005678 arginine finger; other site 1294143005679 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143005680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143005681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143005682 dimer interface [polypeptide binding]; other site 1294143005683 phosphorylation site [posttranslational modification] 1294143005684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143005685 ATP binding site [chemical binding]; other site 1294143005686 Mg2+ binding site [ion binding]; other site 1294143005687 G-X-G motif; other site 1294143005688 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1294143005689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143005690 active site 1294143005691 phosphorylation site [posttranslational modification] 1294143005692 intermolecular recognition site; other site 1294143005693 dimerization interface [polypeptide binding]; other site 1294143005694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143005695 Walker A motif; other site 1294143005696 ATP binding site [chemical binding]; other site 1294143005697 Walker B motif; other site 1294143005698 arginine finger; other site 1294143005699 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143005700 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1294143005701 putative active site [active] 1294143005702 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1294143005703 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1294143005704 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1294143005705 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1294143005706 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1294143005707 MgtE intracellular N domain; Region: MgtE_N; cl15244 1294143005708 FliG C-terminal domain; Region: FliG_C; pfam01706 1294143005709 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1294143005710 Flagellar assembly protein FliH; Region: FliH; pfam02108 1294143005711 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 1294143005712 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1294143005713 Walker A motif/ATP binding site; other site 1294143005714 Walker B motif; other site 1294143005715 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1294143005716 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1294143005717 TPR repeat; Region: TPR_11; pfam13414 1294143005718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1294143005719 binding surface 1294143005720 TPR motif; other site 1294143005721 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1294143005722 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1294143005723 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1294143005724 anti sigma factor interaction site; other site 1294143005725 regulatory phosphorylation site [posttranslational modification]; other site 1294143005726 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143005727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143005728 active site 1294143005729 phosphorylation site [posttranslational modification] 1294143005730 intermolecular recognition site; other site 1294143005731 dimerization interface [polypeptide binding]; other site 1294143005732 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1294143005733 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1294143005734 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1294143005735 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143005736 putative binding surface; other site 1294143005737 active site 1294143005738 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1294143005739 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1294143005740 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 1294143005741 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1294143005742 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1294143005743 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1294143005744 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1294143005745 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1294143005746 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1294143005747 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1294143005748 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1294143005749 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1294143005750 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1294143005751 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143005752 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 1294143005753 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1294143005754 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1294143005755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143005756 putative substrate translocation pore; other site 1294143005757 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1294143005758 putative substrate binding pocket [chemical binding]; other site 1294143005759 trimer interface [polypeptide binding]; other site 1294143005760 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1294143005761 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1294143005762 putative active site [active] 1294143005763 putative metal binding site [ion binding]; other site 1294143005764 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1294143005765 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1294143005766 NAD binding site [chemical binding]; other site 1294143005767 catalytic residues [active] 1294143005768 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1294143005769 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1294143005770 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1294143005771 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1294143005772 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1294143005773 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1294143005774 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1294143005775 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143005776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143005777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143005778 putative substrate translocation pore; other site 1294143005779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143005780 H+ Antiporter protein; Region: 2A0121; TIGR00900 1294143005781 putative substrate translocation pore; other site 1294143005782 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143005783 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1294143005784 Flavin binding site [chemical binding]; other site 1294143005785 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1294143005786 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1294143005787 FHIPEP family; Region: FHIPEP; pfam00771 1294143005788 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1294143005789 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1294143005790 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1294143005791 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1294143005792 P-loop; other site 1294143005793 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1294143005794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143005795 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1294143005796 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143005797 DNA binding residues [nucleotide binding] 1294143005798 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1294143005799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143005800 active site 1294143005801 phosphorylation site [posttranslational modification] 1294143005802 intermolecular recognition site; other site 1294143005803 dimerization interface [polypeptide binding]; other site 1294143005804 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 1294143005805 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143005806 putative binding surface; other site 1294143005807 active site 1294143005808 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1294143005809 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1294143005810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143005811 ATP binding site [chemical binding]; other site 1294143005812 Mg2+ binding site [ion binding]; other site 1294143005813 G-X-G motif; other site 1294143005814 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1294143005815 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1294143005816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143005817 active site 1294143005818 phosphorylation site [posttranslational modification] 1294143005819 intermolecular recognition site; other site 1294143005820 dimerization interface [polypeptide binding]; other site 1294143005821 CheB methylesterase; Region: CheB_methylest; pfam01339 1294143005822 flagellar motor protein; Reviewed; Region: motC; PRK09109 1294143005823 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1294143005824 flagellar motor protein MotD; Reviewed; Region: PRK09038 1294143005825 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1294143005826 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143005827 ligand binding site [chemical binding]; other site 1294143005828 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1294143005829 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1294143005830 P-loop; other site 1294143005831 Magnesium ion binding site [ion binding]; other site 1294143005832 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1294143005833 Magnesium ion binding site [ion binding]; other site 1294143005834 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1294143005835 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1294143005836 putative CheA interaction surface; other site 1294143005837 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1294143005838 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1294143005839 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1294143005840 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1294143005841 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1294143005842 Walker A/P-loop; other site 1294143005843 ATP binding site [chemical binding]; other site 1294143005844 Q-loop/lid; other site 1294143005845 ABC transporter signature motif; other site 1294143005846 Walker B; other site 1294143005847 D-loop; other site 1294143005848 H-loop/switch region; other site 1294143005849 CcmB protein; Region: CcmB; cl17444 1294143005850 heme exporter protein CcmC; Region: ccmC; TIGR01191 1294143005851 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1294143005852 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1294143005853 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1294143005854 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1294143005855 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1294143005856 catalytic residues [active] 1294143005857 central insert; other site 1294143005858 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1294143005859 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1294143005860 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1294143005861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143005862 binding surface 1294143005863 TPR motif; other site 1294143005864 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143005865 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143005866 metal binding site [ion binding]; metal-binding site 1294143005867 active site 1294143005868 I-site; other site 1294143005869 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1294143005870 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1294143005871 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1294143005872 TrkA-N domain; Region: TrkA_N; pfam02254 1294143005873 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1294143005874 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1294143005875 RNA binding surface [nucleotide binding]; other site 1294143005876 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1294143005877 active site 1294143005878 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1294143005879 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1294143005880 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143005881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143005882 Walker A/P-loop; other site 1294143005883 ATP binding site [chemical binding]; other site 1294143005884 Q-loop/lid; other site 1294143005885 ABC transporter signature motif; other site 1294143005886 Walker B; other site 1294143005887 D-loop; other site 1294143005888 H-loop/switch region; other site 1294143005889 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1294143005890 S1 domain; Region: S1_2; pfam13509 1294143005891 S1 domain; Region: S1_2; pfam13509 1294143005892 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1294143005893 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1294143005894 active site 1294143005895 catalytic residues [active] 1294143005896 metal binding site [ion binding]; metal-binding site 1294143005897 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1294143005898 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1294143005899 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1294143005900 Walker A motif; other site 1294143005901 ATP binding site [chemical binding]; other site 1294143005902 Walker B motif; other site 1294143005903 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1294143005904 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1294143005905 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1294143005906 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1294143005907 Cache domain; Region: Cache_1; pfam02743 1294143005908 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143005909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143005910 metal binding site [ion binding]; metal-binding site 1294143005911 active site 1294143005912 I-site; other site 1294143005913 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1294143005914 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1294143005915 hypothetical protein; Provisional; Region: PRK11171 1294143005916 Cupin domain; Region: Cupin_2; pfam07883 1294143005917 Cupin domain; Region: Cupin_2; pfam07883 1294143005918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143005919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143005920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143005921 dimerization interface [polypeptide binding]; other site 1294143005922 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1294143005923 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1294143005924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143005925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143005926 Walker A/P-loop; other site 1294143005927 ATP binding site [chemical binding]; other site 1294143005928 Q-loop/lid; other site 1294143005929 ABC transporter signature motif; other site 1294143005930 Walker B; other site 1294143005931 D-loop; other site 1294143005932 H-loop/switch region; other site 1294143005933 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1294143005934 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143005935 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143005936 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143005937 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 1294143005938 putative ADP-binding pocket [chemical binding]; other site 1294143005939 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1294143005940 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1294143005941 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1294143005942 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1294143005943 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1294143005944 BRO family, N-terminal domain; Region: Bro-N; cl10591 1294143005945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1294143005946 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1294143005947 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1294143005948 dimer interface [polypeptide binding]; other site 1294143005949 putative radical transfer pathway; other site 1294143005950 diiron center [ion binding]; other site 1294143005951 tyrosyl radical; other site 1294143005952 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1294143005953 ATP cone domain; Region: ATP-cone; pfam03477 1294143005954 ATP cone domain; Region: ATP-cone; pfam03477 1294143005955 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1294143005956 active site 1294143005957 dimer interface [polypeptide binding]; other site 1294143005958 catalytic residues [active] 1294143005959 effector binding site; other site 1294143005960 R2 peptide binding site; other site 1294143005961 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1294143005962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143005963 active site 1294143005964 phosphorylation site [posttranslational modification] 1294143005965 intermolecular recognition site; other site 1294143005966 dimerization interface [polypeptide binding]; other site 1294143005967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143005968 DNA binding site [nucleotide binding] 1294143005969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143005970 dimerization interface [polypeptide binding]; other site 1294143005971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143005972 dimer interface [polypeptide binding]; other site 1294143005973 phosphorylation site [posttranslational modification] 1294143005974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143005975 ATP binding site [chemical binding]; other site 1294143005976 Mg2+ binding site [ion binding]; other site 1294143005977 G-X-G motif; other site 1294143005978 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1294143005979 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 1294143005980 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1294143005981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143005982 dimer interface [polypeptide binding]; other site 1294143005983 conserved gate region; other site 1294143005984 putative PBP binding loops; other site 1294143005985 ABC-ATPase subunit interface; other site 1294143005986 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1294143005987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143005988 Walker A/P-loop; other site 1294143005989 ATP binding site [chemical binding]; other site 1294143005990 Q-loop/lid; other site 1294143005991 ABC transporter signature motif; other site 1294143005992 Walker B; other site 1294143005993 D-loop; other site 1294143005994 H-loop/switch region; other site 1294143005995 TOBE domain; Region: TOBE; pfam03459 1294143005996 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143005997 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1294143005998 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1294143005999 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1294143006000 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1294143006001 Alginate lyase; Region: Alginate_lyase2; pfam08787 1294143006002 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1294143006003 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143006004 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143006005 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1294143006006 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1294143006007 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1294143006008 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1294143006009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143006010 active site 1294143006011 phosphorylation site [posttranslational modification] 1294143006012 intermolecular recognition site; other site 1294143006013 dimerization interface [polypeptide binding]; other site 1294143006014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143006015 DNA binding site [nucleotide binding] 1294143006016 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1294143006017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143006018 dimer interface [polypeptide binding]; other site 1294143006019 phosphorylation site [posttranslational modification] 1294143006020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143006021 ATP binding site [chemical binding]; other site 1294143006022 Mg2+ binding site [ion binding]; other site 1294143006023 G-X-G motif; other site 1294143006024 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143006025 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143006026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143006027 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1294143006028 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1294143006029 MASE2 domain; Region: MASE2; pfam05230 1294143006030 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1294143006031 cyclase homology domain; Region: CHD; cd07302 1294143006032 nucleotidyl binding site; other site 1294143006033 metal binding site [ion binding]; metal-binding site 1294143006034 dimer interface [polypeptide binding]; other site 1294143006035 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 1294143006036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143006037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143006038 DNA binding residues [nucleotide binding] 1294143006039 dimerization interface [polypeptide binding]; other site 1294143006040 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1294143006041 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1294143006042 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1294143006043 serine/threonine transporter SstT; Provisional; Region: PRK13628 1294143006044 Urea transporter; Region: UT; cl01829 1294143006045 pyruvate kinase; Provisional; Region: PRK06247 1294143006046 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1294143006047 domain interfaces; other site 1294143006048 active site 1294143006049 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1294143006050 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1294143006051 MOFRL family; Region: MOFRL; pfam05161 1294143006052 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1294143006053 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1294143006054 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1294143006055 glyoxylate carboligase; Provisional; Region: PRK11269 1294143006056 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1294143006057 PYR/PP interface [polypeptide binding]; other site 1294143006058 dimer interface [polypeptide binding]; other site 1294143006059 TPP binding site [chemical binding]; other site 1294143006060 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1294143006061 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1294143006062 TPP-binding site [chemical binding]; other site 1294143006063 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1294143006064 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1294143006065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143006066 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1294143006067 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1294143006068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143006069 FeS/SAM binding site; other site 1294143006070 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1294143006071 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143006072 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 1294143006073 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1294143006074 active site 1294143006075 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1294143006076 putative active site [active] 1294143006077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143006078 binding surface 1294143006079 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1294143006080 TPR motif; other site 1294143006081 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1294143006082 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143006083 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143006084 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 1294143006085 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1294143006086 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1294143006087 catalytic site [active] 1294143006088 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1294143006089 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1294143006090 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1294143006091 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1294143006092 active site 1294143006093 dimer interface [polypeptide binding]; other site 1294143006094 motif 1; other site 1294143006095 motif 2; other site 1294143006096 motif 3; other site 1294143006097 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1294143006098 anticodon binding site; other site 1294143006099 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1294143006100 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1294143006101 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1294143006102 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1294143006103 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1294143006104 23S rRNA binding site [nucleotide binding]; other site 1294143006105 L21 binding site [polypeptide binding]; other site 1294143006106 L13 binding site [polypeptide binding]; other site 1294143006107 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1294143006108 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1294143006109 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1294143006110 dimer interface [polypeptide binding]; other site 1294143006111 motif 1; other site 1294143006112 active site 1294143006113 motif 2; other site 1294143006114 motif 3; other site 1294143006115 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1294143006116 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1294143006117 putative tRNA-binding site [nucleotide binding]; other site 1294143006118 B3/4 domain; Region: B3_4; pfam03483 1294143006119 tRNA synthetase B5 domain; Region: B5; smart00874 1294143006120 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1294143006121 dimer interface [polypeptide binding]; other site 1294143006122 motif 1; other site 1294143006123 motif 3; other site 1294143006124 motif 2; other site 1294143006125 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1294143006126 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1294143006127 IHF dimer interface [polypeptide binding]; other site 1294143006128 IHF - DNA interface [nucleotide binding]; other site 1294143006129 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1294143006130 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1294143006131 DNA binding residues [nucleotide binding] 1294143006132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143006133 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143006134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143006135 DNA-binding site [nucleotide binding]; DNA binding site 1294143006136 FCD domain; Region: FCD; pfam07729 1294143006137 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1294143006138 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1294143006139 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1294143006140 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1294143006141 active site 1294143006142 metal binding site [ion binding]; metal-binding site 1294143006143 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1294143006144 putative active site [active] 1294143006145 putative metal binding site [ion binding]; other site 1294143006146 FAD binding domain; Region: FAD_binding_3; pfam01494 1294143006147 hypothetical protein; Provisional; Region: PRK07236 1294143006148 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1294143006149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143006150 D-galactonate transporter; Region: 2A0114; TIGR00893 1294143006151 putative substrate translocation pore; other site 1294143006152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1294143006153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143006154 Coenzyme A binding pocket [chemical binding]; other site 1294143006155 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 1294143006156 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1294143006157 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 1294143006158 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1294143006159 VirB7 interaction site; other site 1294143006160 conjugal transfer protein TrbF; Provisional; Region: PRK13872 1294143006161 conjugal transfer protein TrbL; Provisional; Region: PRK13875 1294143006162 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1294143006163 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 1294143006164 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 1294143006165 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 1294143006166 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1294143006167 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1294143006168 Walker A motif; other site 1294143006169 ATP binding site [chemical binding]; other site 1294143006170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143006171 Walker B; other site 1294143006172 D-loop; other site 1294143006173 H-loop/switch region; other site 1294143006174 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 1294143006175 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1294143006176 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1294143006177 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1294143006178 ATP binding site [chemical binding]; other site 1294143006179 Walker A motif; other site 1294143006180 hexamer interface [polypeptide binding]; other site 1294143006181 Walker B motif; other site 1294143006182 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 1294143006183 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 1294143006184 Walker A motif; other site 1294143006185 ATP binding site [chemical binding]; other site 1294143006186 Walker B motif; other site 1294143006187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143006188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143006189 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1294143006190 dimerization interface [polypeptide binding]; other site 1294143006191 substrate binding pocket [chemical binding]; other site 1294143006192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143006193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143006194 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1294143006195 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1294143006196 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143006197 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143006198 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1294143006199 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1294143006200 Walker A/P-loop; other site 1294143006201 ATP binding site [chemical binding]; other site 1294143006202 Q-loop/lid; other site 1294143006203 ABC transporter signature motif; other site 1294143006204 Walker B; other site 1294143006205 D-loop; other site 1294143006206 H-loop/switch region; other site 1294143006207 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1294143006208 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1294143006209 Walker A/P-loop; other site 1294143006210 ATP binding site [chemical binding]; other site 1294143006211 Q-loop/lid; other site 1294143006212 ABC transporter signature motif; other site 1294143006213 Walker B; other site 1294143006214 D-loop; other site 1294143006215 H-loop/switch region; other site 1294143006216 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143006217 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1294143006218 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143006219 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1294143006220 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1294143006221 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1294143006222 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1294143006223 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1294143006224 Beta-Casp domain; Region: Beta-Casp; smart01027 1294143006225 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1294143006226 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1294143006227 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 1294143006228 Cytochrome C' Region: Cytochrom_C_2; cl01610 1294143006229 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1294143006230 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 1294143006231 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1294143006232 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1294143006233 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 1294143006234 ParA-like protein; Provisional; Region: PHA02518 1294143006235 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1294143006236 P-loop; other site 1294143006237 Magnesium ion binding site [ion binding]; other site 1294143006238 Replication initiator protein A; Region: RPA; pfam10134 1294143006239 Helix-turn-helix domain; Region: HTH_17; cl17695 1294143006240 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 1294143006241 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 1294143006242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143006243 non-specific DNA binding site [nucleotide binding]; other site 1294143006244 salt bridge; other site 1294143006245 sequence-specific DNA binding site [nucleotide binding]; other site 1294143006246 Uncharacterized conserved protein [Function unknown]; Region: COG5489 1294143006247 ParB-like nuclease domain; Region: ParBc; pfam02195 1294143006248 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1294143006249 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 1294143006250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1294143006251 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1294143006252 SIR2-like domain; Region: SIR2_2; pfam13289 1294143006253 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1294143006254 Domain of unknown function DUF87; Region: DUF87; pfam01935 1294143006255 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1294143006256 KTSC domain; Region: KTSC; pfam13619 1294143006257 Predicted transcriptional regulator [Transcription]; Region: COG2944 1294143006258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143006259 non-specific DNA binding site [nucleotide binding]; other site 1294143006260 salt bridge; other site 1294143006261 sequence-specific DNA binding site [nucleotide binding]; other site 1294143006262 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 1294143006263 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143006264 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1294143006265 active site 1294143006266 Int/Topo IB signature motif; other site 1294143006267 DNA binding site [nucleotide binding] 1294143006268 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1294143006269 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1294143006270 dimer interface [polypeptide binding]; other site 1294143006271 active site 1294143006272 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1294143006273 active site 1 [active] 1294143006274 dimer interface [polypeptide binding]; other site 1294143006275 active site 2 [active] 1294143006276 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1294143006277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143006278 dimerization interface [polypeptide binding]; other site 1294143006279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143006280 dimer interface [polypeptide binding]; other site 1294143006281 phosphorylation site [posttranslational modification] 1294143006282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143006283 ATP binding site [chemical binding]; other site 1294143006284 Mg2+ binding site [ion binding]; other site 1294143006285 G-X-G motif; other site 1294143006286 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143006287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143006288 active site 1294143006289 phosphorylation site [posttranslational modification] 1294143006290 intermolecular recognition site; other site 1294143006291 dimerization interface [polypeptide binding]; other site 1294143006292 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1294143006293 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1294143006294 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1294143006295 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1294143006296 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1294143006297 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1294143006298 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1294143006299 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1294143006300 catalytic core [active] 1294143006301 MgtC family; Region: MgtC; pfam02308 1294143006302 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1294143006303 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 1294143006304 acyl-activating enzyme (AAE) consensus motif; other site 1294143006305 putative AMP binding site [chemical binding]; other site 1294143006306 putative active site [active] 1294143006307 putative CoA binding site [chemical binding]; other site 1294143006308 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143006309 CoenzymeA binding site [chemical binding]; other site 1294143006310 subunit interaction site [polypeptide binding]; other site 1294143006311 PHB binding site; other site 1294143006312 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143006313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143006314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143006315 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1294143006316 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143006317 DEAD/H associated; Region: DEAD_assoc; pfam08494 1294143006318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143006319 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1294143006320 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1294143006321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143006322 putative substrate translocation pore; other site 1294143006323 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1294143006324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143006325 DNA-binding site [nucleotide binding]; DNA binding site 1294143006326 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1294143006327 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1294143006328 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1294143006329 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1294143006330 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1294143006331 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1294143006332 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1294143006333 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1294143006334 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1294143006335 Ligand Binding Site [chemical binding]; other site 1294143006336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143006337 dimer interface [polypeptide binding]; other site 1294143006338 phosphorylation site [posttranslational modification] 1294143006339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143006340 ATP binding site [chemical binding]; other site 1294143006341 Mg2+ binding site [ion binding]; other site 1294143006342 G-X-G motif; other site 1294143006343 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1294143006344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143006345 active site 1294143006346 phosphorylation site [posttranslational modification] 1294143006347 intermolecular recognition site; other site 1294143006348 dimerization interface [polypeptide binding]; other site 1294143006349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143006350 DNA binding site [nucleotide binding] 1294143006351 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1294143006352 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1294143006353 active site 1294143006354 nucleophile elbow; other site 1294143006355 selenophosphate synthetase; Provisional; Region: PRK00943 1294143006356 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1294143006357 dimerization interface [polypeptide binding]; other site 1294143006358 putative ATP binding site [chemical binding]; other site 1294143006359 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1294143006360 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1294143006361 active site residue [active] 1294143006362 Staphylococcal nuclease homologues; Region: SNc; smart00318 1294143006363 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1294143006364 Catalytic site; other site 1294143006365 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1294143006366 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1294143006367 active site 1294143006368 catalytic tetrad [active] 1294143006369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143006370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143006371 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1294143006372 putative effector binding pocket; other site 1294143006373 putative dimerization interface [polypeptide binding]; other site 1294143006374 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1294143006375 dimer interface [polypeptide binding]; other site 1294143006376 catalytic triad [active] 1294143006377 peroxidatic and resolving cysteines [active] 1294143006378 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143006379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143006380 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143006381 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1294143006382 Protein export membrane protein; Region: SecD_SecF; cl14618 1294143006383 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 1294143006384 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1294143006385 Protein export membrane protein; Region: SecD_SecF; cl14618 1294143006386 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1294143006387 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1294143006388 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1294143006389 conserved cys residue [active] 1294143006390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143006391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143006392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143006393 dimerization interface [polypeptide binding]; other site 1294143006394 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1294143006395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143006396 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143006397 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143006398 putative effector binding pocket; other site 1294143006399 dimerization interface [polypeptide binding]; other site 1294143006400 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1294143006401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143006402 NAD(P) binding site [chemical binding]; other site 1294143006403 active site 1294143006404 Predicted membrane protein [Function unknown]; Region: COG1289 1294143006405 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1294143006406 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1294143006407 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1294143006408 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143006409 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143006410 metal binding site [ion binding]; metal-binding site 1294143006411 active site 1294143006412 I-site; other site 1294143006413 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143006414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143006415 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1294143006416 dimerization interface [polypeptide binding]; other site 1294143006417 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1294143006418 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1294143006419 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1294143006420 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1294143006421 nucleoside/Zn binding site; other site 1294143006422 dimer interface [polypeptide binding]; other site 1294143006423 catalytic motif [active] 1294143006424 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1294143006425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143006426 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1294143006427 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1294143006428 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143006429 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143006430 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143006431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143006432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143006433 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1294143006434 putative substrate binding pocket [chemical binding]; other site 1294143006435 putative dimerization interface [polypeptide binding]; other site 1294143006436 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1294143006437 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1294143006438 putative NAD(P) binding site [chemical binding]; other site 1294143006439 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1294143006440 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1294143006441 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1294143006442 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1294143006443 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1294143006444 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1294143006445 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1294143006446 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1294143006447 NAD(P) binding site [chemical binding]; other site 1294143006448 substrate binding site [chemical binding]; other site 1294143006449 dimer interface [polypeptide binding]; other site 1294143006450 short chain dehydrogenase; Provisional; Region: PRK06172 1294143006451 classical (c) SDRs; Region: SDR_c; cd05233 1294143006452 NAD(P) binding site [chemical binding]; other site 1294143006453 active site 1294143006454 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1294143006455 Sodium Bile acid symporter family; Region: SBF; cl17470 1294143006456 Predicted ATPase [General function prediction only]; Region: COG4637 1294143006457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143006458 Walker A/P-loop; other site 1294143006459 ATP binding site [chemical binding]; other site 1294143006460 benzoate transporter; Region: benE; TIGR00843 1294143006461 Benzoate membrane transport protein; Region: BenE; pfam03594 1294143006462 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1294143006463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1294143006464 MarR family; Region: MarR_2; pfam12802 1294143006465 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1294143006466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143006467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143006468 homodimer interface [polypeptide binding]; other site 1294143006469 catalytic residue [active] 1294143006470 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143006471 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1294143006472 putative C-terminal domain interface [polypeptide binding]; other site 1294143006473 putative GSH binding site (G-site) [chemical binding]; other site 1294143006474 putative dimer interface [polypeptide binding]; other site 1294143006475 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1294143006476 N-terminal domain interface [polypeptide binding]; other site 1294143006477 dimer interface [polypeptide binding]; other site 1294143006478 substrate binding pocket (H-site) [chemical binding]; other site 1294143006479 Hemerythrin; Region: Hemerythrin; cd12107 1294143006480 Fe binding site [ion binding]; other site 1294143006481 Cache domain; Region: Cache_2; cl07034 1294143006482 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1294143006483 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1294143006484 homodecamer interface [polypeptide binding]; other site 1294143006485 GTP cyclohydrolase I; Provisional; Region: PLN03044 1294143006486 active site 1294143006487 putative catalytic site residues [active] 1294143006488 zinc binding site [ion binding]; other site 1294143006489 GTP-CH-I/GFRP interaction surface; other site 1294143006490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1294143006491 Smr domain; Region: Smr; pfam01713 1294143006492 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1294143006493 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143006494 catalytic triad [active] 1294143006495 conserved cis-peptide bond; other site 1294143006496 HemK family putative methylases; Region: hemK_fam; TIGR00536 1294143006497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143006498 S-adenosylmethionine binding site [chemical binding]; other site 1294143006499 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1294143006500 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1294143006501 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1294143006502 Tetramer interface [polypeptide binding]; other site 1294143006503 active site 1294143006504 FMN-binding site [chemical binding]; other site 1294143006505 potential frameshift: common BLAST hit: gi|392984853|ref|YP_006483440.1| MFS metabolite transporter 1294143006506 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1294143006507 intersubunit interface [polypeptide binding]; other site 1294143006508 active site 1294143006509 Zn2+ binding site [ion binding]; other site 1294143006510 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1294143006511 Cupin domain; Region: Cupin_2; cl17218 1294143006512 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1294143006513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143006514 motif II; other site 1294143006515 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1294143006516 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1294143006517 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1294143006518 DNA binding site [nucleotide binding] 1294143006519 active site 1294143006520 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1294143006521 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1294143006522 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1294143006523 DNA binding site [nucleotide binding] 1294143006524 active site 1294143006525 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1294143006526 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1294143006527 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1294143006528 minor groove reading motif; other site 1294143006529 helix-hairpin-helix signature motif; other site 1294143006530 substrate binding pocket [chemical binding]; other site 1294143006531 active site 1294143006532 spermidine synthase; Provisional; Region: PRK00811 1294143006533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143006534 S-adenosylmethionine binding site [chemical binding]; other site 1294143006535 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1294143006536 Sulfatase; Region: Sulfatase; pfam00884 1294143006537 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1294143006538 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143006539 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143006540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143006541 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1294143006542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1294143006543 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1294143006544 short chain dehydrogenase; Provisional; Region: PRK08267 1294143006545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143006546 NAD(P) binding site [chemical binding]; other site 1294143006547 active site 1294143006548 EamA-like transporter family; Region: EamA; pfam00892 1294143006549 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1294143006550 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1294143006551 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1294143006552 catalytic triad [active] 1294143006553 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1294143006554 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1294143006555 tetrameric interface [polypeptide binding]; other site 1294143006556 NAD binding site [chemical binding]; other site 1294143006557 catalytic residues [active] 1294143006558 substrate binding site [chemical binding]; other site 1294143006559 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1294143006560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143006561 dimer interface [polypeptide binding]; other site 1294143006562 conserved gate region; other site 1294143006563 putative PBP binding loops; other site 1294143006564 ABC-ATPase subunit interface; other site 1294143006565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143006566 dimer interface [polypeptide binding]; other site 1294143006567 conserved gate region; other site 1294143006568 putative PBP binding loops; other site 1294143006569 ABC-ATPase subunit interface; other site 1294143006570 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1294143006571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143006572 Walker A/P-loop; other site 1294143006573 ATP binding site [chemical binding]; other site 1294143006574 Q-loop/lid; other site 1294143006575 ABC transporter signature motif; other site 1294143006576 Walker B; other site 1294143006577 D-loop; other site 1294143006578 H-loop/switch region; other site 1294143006579 TOBE domain; Region: TOBE_2; pfam08402 1294143006580 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1294143006581 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143006582 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143006583 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1294143006584 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143006585 dimer interface [polypeptide binding]; other site 1294143006586 active site 1294143006587 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1294143006588 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143006589 substrate binding site [chemical binding]; other site 1294143006590 oxyanion hole (OAH) forming residues; other site 1294143006591 trimer interface [polypeptide binding]; other site 1294143006592 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143006593 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143006594 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1294143006595 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1294143006596 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1294143006597 catalytic triad [active] 1294143006598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1294143006599 Homeodomain-like domain; Region: HTH_23; cl17451 1294143006600 Integrase core domain; Region: rve; pfam00665 1294143006601 Integrase core domain; Region: rve_3; pfam13683 1294143006602 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1294143006603 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1294143006604 oligomer interface [polypeptide binding]; other site 1294143006605 metal binding site [ion binding]; metal-binding site 1294143006606 metal binding site [ion binding]; metal-binding site 1294143006607 putative Cl binding site [ion binding]; other site 1294143006608 basic sphincter; other site 1294143006609 hydrophobic gate; other site 1294143006610 periplasmic entrance; other site 1294143006611 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1294143006612 ADP-ribose binding site [chemical binding]; other site 1294143006613 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1294143006614 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143006615 substrate binding site [chemical binding]; other site 1294143006616 oxyanion hole (OAH) forming residues; other site 1294143006617 trimer interface [polypeptide binding]; other site 1294143006618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143006619 Coenzyme A binding pocket [chemical binding]; other site 1294143006620 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1294143006621 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1294143006622 PilZ domain; Region: PilZ; pfam07238 1294143006623 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1294143006624 catalytic residues [active] 1294143006625 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1294143006626 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1294143006627 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1294143006628 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1294143006629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143006630 Ligand Binding Site [chemical binding]; other site 1294143006631 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1294143006632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143006633 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1294143006634 substrate binding site [chemical binding]; other site 1294143006635 dimerization interface [polypeptide binding]; other site 1294143006636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143006637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143006638 putative substrate translocation pore; other site 1294143006639 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1294143006640 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1294143006641 Active Sites [active] 1294143006642 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 1294143006643 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1294143006644 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1294143006645 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1294143006646 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1294143006647 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1294143006648 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143006649 DNA binding residues [nucleotide binding] 1294143006650 dimerization interface [polypeptide binding]; other site 1294143006651 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1294143006652 AAA ATPase domain; Region: AAA_16; pfam13191 1294143006653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143006654 DNA binding residues [nucleotide binding] 1294143006655 dimerization interface [polypeptide binding]; other site 1294143006656 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1294143006657 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1294143006658 putative active site [active] 1294143006659 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1294143006660 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1294143006661 Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148 1294143006662 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1294143006663 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1294143006664 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1294143006665 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1294143006666 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1294143006667 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1294143006668 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1294143006669 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1294143006670 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1294143006671 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1294143006672 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1294143006673 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143006674 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143006675 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1294143006676 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1294143006677 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1294143006678 Cl binding site [ion binding]; other site 1294143006679 oligomer interface [polypeptide binding]; other site 1294143006680 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 1294143006681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143006682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143006683 DNA binding residues [nucleotide binding] 1294143006684 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1294143006685 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143006686 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143006687 ligand binding site [chemical binding]; other site 1294143006688 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1294143006689 active site 1294143006690 SAM binding site [chemical binding]; other site 1294143006691 homodimer interface [polypeptide binding]; other site 1294143006692 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1294143006693 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1294143006694 [4Fe-4S] binding site [ion binding]; other site 1294143006695 molybdopterin cofactor binding site; other site 1294143006696 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1294143006697 molybdopterin cofactor binding site; other site 1294143006698 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1294143006699 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1294143006700 [2Fe-2S] cluster binding site [ion binding]; other site 1294143006701 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1294143006702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143006703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143006704 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1294143006705 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1294143006706 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1294143006707 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1294143006708 active site 1294143006709 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1294143006710 active site 1294143006711 ATP binding site [chemical binding]; other site 1294143006712 substrate binding site [chemical binding]; other site 1294143006713 activation loop (A-loop); other site 1294143006714 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1294143006715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143006716 putative substrate translocation pore; other site 1294143006717 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1294143006718 active site 1294143006719 Alginate lyase; Region: Alginate_lyase2; pfam08787 1294143006720 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1294143006721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143006722 active site 1294143006723 phosphorylation site [posttranslational modification] 1294143006724 intermolecular recognition site; other site 1294143006725 dimerization interface [polypeptide binding]; other site 1294143006726 ANTAR domain; Region: ANTAR; pfam03861 1294143006727 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1294143006728 NMT1-like family; Region: NMT1_2; pfam13379 1294143006729 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1294143006730 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1294143006731 substrate binding site [chemical binding]; other site 1294143006732 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1294143006733 substrate binding site [chemical binding]; other site 1294143006734 ligand binding site [chemical binding]; other site 1294143006735 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1294143006736 universal stress protein UspE; Provisional; Region: PRK11175 1294143006737 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143006738 Ligand Binding Site [chemical binding]; other site 1294143006739 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143006740 Ligand Binding Site [chemical binding]; other site 1294143006741 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1294143006742 active site 1294143006743 dinuclear metal binding site [ion binding]; other site 1294143006744 dimerization interface [polypeptide binding]; other site 1294143006745 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1294143006746 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1294143006747 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1294143006748 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1294143006749 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1294143006750 putative active site [active] 1294143006751 putative metal binding site [ion binding]; other site 1294143006752 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1294143006753 substrate binding site [chemical binding]; other site 1294143006754 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1294143006755 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1294143006756 active site 1294143006757 HIGH motif; other site 1294143006758 nucleotide binding site [chemical binding]; other site 1294143006759 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1294143006760 KMSKS motif; other site 1294143006761 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1294143006762 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1294143006763 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1294143006764 active site 1294143006765 HIGH motif; other site 1294143006766 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1294143006767 KMSKS motif; other site 1294143006768 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1294143006769 tRNA binding surface [nucleotide binding]; other site 1294143006770 anticodon binding site; other site 1294143006771 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1294143006772 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1294143006773 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1294143006774 homodimer interface [polypeptide binding]; other site 1294143006775 NADP binding site [chemical binding]; other site 1294143006776 substrate binding site [chemical binding]; other site 1294143006777 trigger factor; Provisional; Region: tig; PRK01490 1294143006778 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1294143006779 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1294143006780 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1294143006781 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1294143006782 oligomer interface [polypeptide binding]; other site 1294143006783 active site residues [active] 1294143006784 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1294143006785 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1294143006786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143006787 Walker A motif; other site 1294143006788 ATP binding site [chemical binding]; other site 1294143006789 Walker B motif; other site 1294143006790 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1294143006791 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1294143006792 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1294143006793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143006794 Walker A motif; other site 1294143006795 ATP binding site [chemical binding]; other site 1294143006796 Walker B motif; other site 1294143006797 arginine finger; other site 1294143006798 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1294143006799 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1294143006800 IHF dimer interface [polypeptide binding]; other site 1294143006801 IHF - DNA interface [nucleotide binding]; other site 1294143006802 periplasmic folding chaperone; Provisional; Region: PRK10788 1294143006803 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1294143006804 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1294143006805 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1294143006806 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1294143006807 NAD binding site [chemical binding]; other site 1294143006808 homotetramer interface [polypeptide binding]; other site 1294143006809 homodimer interface [polypeptide binding]; other site 1294143006810 substrate binding site [chemical binding]; other site 1294143006811 active site 1294143006812 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1294143006813 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1294143006814 Walker A/P-loop; other site 1294143006815 ATP binding site [chemical binding]; other site 1294143006816 Q-loop/lid; other site 1294143006817 ABC transporter signature motif; other site 1294143006818 Walker B; other site 1294143006819 D-loop; other site 1294143006820 H-loop/switch region; other site 1294143006821 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1294143006822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1294143006823 Walker A/P-loop; other site 1294143006824 ATP binding site [chemical binding]; other site 1294143006825 Q-loop/lid; other site 1294143006826 ABC transporter signature motif; other site 1294143006827 Walker B; other site 1294143006828 D-loop; other site 1294143006829 H-loop/switch region; other site 1294143006830 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1294143006831 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1294143006832 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1294143006833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143006834 dimer interface [polypeptide binding]; other site 1294143006835 conserved gate region; other site 1294143006836 putative PBP binding loops; other site 1294143006837 ABC-ATPase subunit interface; other site 1294143006838 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1294143006839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143006840 dimer interface [polypeptide binding]; other site 1294143006841 conserved gate region; other site 1294143006842 putative PBP binding loops; other site 1294143006843 ABC-ATPase subunit interface; other site 1294143006844 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1294143006845 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1294143006846 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1294143006847 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1294143006848 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1294143006849 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143006850 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143006851 catalytic residue [active] 1294143006852 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143006853 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143006854 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1294143006855 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143006856 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1294143006857 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1294143006858 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1294143006859 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1294143006860 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1294143006861 RNA/DNA hybrid binding site [nucleotide binding]; other site 1294143006862 active site 1294143006863 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1294143006864 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1294143006865 active site 1294143006866 catalytic site [active] 1294143006867 substrate binding site [chemical binding]; other site 1294143006868 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1294143006869 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1294143006870 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1294143006871 homodimer interface [polypeptide binding]; other site 1294143006872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143006873 catalytic residue [active] 1294143006874 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1294143006875 potential frameshift: common BLAST hit: gi|253996336|ref|YP_003048400.1| PAS/PAC and GAF sensor-containing diguanylate 1294143006876 arginine:agmatin antiporter; Provisional; Region: PRK10644 1294143006877 enoyl-CoA hydratase; Provisional; Region: PRK06142 1294143006878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143006879 substrate binding site [chemical binding]; other site 1294143006880 oxyanion hole (OAH) forming residues; other site 1294143006881 trimer interface [polypeptide binding]; other site 1294143006882 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1294143006883 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1294143006884 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1294143006885 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1294143006886 putative NADH binding site [chemical binding]; other site 1294143006887 putative active site [active] 1294143006888 nudix motif; other site 1294143006889 putative metal binding site [ion binding]; other site 1294143006890 hypothetical protein; Provisional; Region: PRK10621 1294143006891 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1294143006892 short chain dehydrogenase; Provisional; Region: PRK07035 1294143006893 classical (c) SDRs; Region: SDR_c; cd05233 1294143006894 NAD(P) binding site [chemical binding]; other site 1294143006895 active site 1294143006896 Phosphotransferase enzyme family; Region: APH; pfam01636 1294143006897 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1294143006898 putative active site [active] 1294143006899 putative substrate binding site [chemical binding]; other site 1294143006900 ATP binding site [chemical binding]; other site 1294143006901 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1294143006902 phosphoglycerate mutase; Provisional; Region: PTZ00122 1294143006903 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1294143006904 catalytic core [active] 1294143006905 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1294143006906 putative inner membrane peptidase; Provisional; Region: PRK11778 1294143006907 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1294143006908 tandem repeat interface [polypeptide binding]; other site 1294143006909 oligomer interface [polypeptide binding]; other site 1294143006910 active site residues [active] 1294143006911 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1294143006912 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1294143006913 NADP binding site [chemical binding]; other site 1294143006914 dimer interface [polypeptide binding]; other site 1294143006915 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1294143006916 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143006917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143006918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143006919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 1294143006920 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1294143006921 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1294143006922 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1294143006923 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143006924 CoenzymeA binding site [chemical binding]; other site 1294143006925 subunit interaction site [polypeptide binding]; other site 1294143006926 PHB binding site; other site 1294143006927 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1294143006928 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 1294143006929 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1294143006930 Protein with unknown function (DUF469); Region: DUF469; cl01237 1294143006931 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1294143006932 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1294143006933 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1294143006934 substrate binding pocket [chemical binding]; other site 1294143006935 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1294143006936 B12 binding site [chemical binding]; other site 1294143006937 cobalt ligand [ion binding]; other site 1294143006938 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1294143006939 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1294143006940 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1294143006941 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1294143006942 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1294143006943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1294143006944 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1294143006945 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143006946 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1294143006947 conserved cys residue [active] 1294143006948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143006949 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 1294143006950 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1294143006951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143006952 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1294143006953 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1294143006954 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1294143006955 active site 1294143006956 Zn binding site [ion binding]; other site 1294143006957 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143006958 CoenzymeA binding site [chemical binding]; other site 1294143006959 subunit interaction site [polypeptide binding]; other site 1294143006960 PHB binding site; other site 1294143006961 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1294143006962 hypothetical protein; Validated; Region: PRK07586 1294143006963 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1294143006964 PYR/PP interface [polypeptide binding]; other site 1294143006965 dimer interface [polypeptide binding]; other site 1294143006966 TPP binding site [chemical binding]; other site 1294143006967 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1294143006968 TPP-binding site [chemical binding]; other site 1294143006969 dimer interface [polypeptide binding]; other site 1294143006970 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1294143006971 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1294143006972 phosphate binding site [ion binding]; other site 1294143006973 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1294143006974 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143006975 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143006976 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1294143006977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143006978 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1294143006979 putative heme binding pocket [chemical binding]; other site 1294143006980 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1294143006981 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1294143006982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143006983 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1294143006984 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1294143006985 Cupin domain; Region: Cupin_2; cl17218 1294143006986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143006987 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1294143006988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143006989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143006990 dimerization interface [polypeptide binding]; other site 1294143006991 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1294143006992 heterodimer interface [polypeptide binding]; other site 1294143006993 multimer interface [polypeptide binding]; other site 1294143006994 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1294143006995 active site 1294143006996 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1294143006997 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1294143006998 heterodimer interface [polypeptide binding]; other site 1294143006999 active site 1294143007000 Predicted ATPase [General function prediction only]; Region: COG1485 1294143007001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1294143007002 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1294143007003 NIPSNAP; Region: NIPSNAP; pfam07978 1294143007004 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1294143007005 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1294143007006 active site 1294143007007 dimer interface [polypeptide binding]; other site 1294143007008 metal binding site [ion binding]; metal-binding site 1294143007009 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1294143007010 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1294143007011 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1294143007012 Zn binding site [ion binding]; other site 1294143007013 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1294143007014 Zn binding site [ion binding]; other site 1294143007015 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1294143007016 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1294143007017 active site 1294143007018 oxalacetate binding site [chemical binding]; other site 1294143007019 citrylCoA binding site [chemical binding]; other site 1294143007020 coenzyme A binding site [chemical binding]; other site 1294143007021 catalytic triad [active] 1294143007022 acyl-CoA synthetase; Validated; Region: PRK06188 1294143007023 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1294143007024 putative active site [active] 1294143007025 putative CoA binding site [chemical binding]; other site 1294143007026 putative AMP binding site [chemical binding]; other site 1294143007027 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1294143007028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143007029 DNA-binding site [nucleotide binding]; DNA binding site 1294143007030 UTRA domain; Region: UTRA; pfam07702 1294143007031 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1294143007032 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1294143007033 Bacterial transcriptional regulator; Region: IclR; pfam01614 1294143007034 hypothetical protein; Provisional; Region: PRK09126 1294143007035 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1294143007036 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 1294143007037 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1294143007038 Predicted transcriptional regulator [Transcription]; Region: COG3905 1294143007039 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1294143007040 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1294143007041 Glutamate binding site [chemical binding]; other site 1294143007042 NAD binding site [chemical binding]; other site 1294143007043 catalytic residues [active] 1294143007044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143007045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143007046 putative substrate translocation pore; other site 1294143007047 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1294143007048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1294143007049 active site 1294143007050 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1294143007051 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1294143007052 bile acid transporter; Region: bass; TIGR00841 1294143007053 Sodium Bile acid symporter family; Region: SBF; cl17470 1294143007054 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143007055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143007056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143007057 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1294143007058 MltA specific insert domain; Region: MltA; smart00925 1294143007059 3D domain; Region: 3D; pfam06725 1294143007060 DNA polymerase II; Reviewed; Region: PRK05762 1294143007061 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1294143007062 active site 1294143007063 catalytic site [active] 1294143007064 substrate binding site [chemical binding]; other site 1294143007065 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1294143007066 active site 1294143007067 metal-binding site 1294143007068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143007069 dimerization interface [polypeptide binding]; other site 1294143007070 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1294143007071 putative DNA binding site [nucleotide binding]; other site 1294143007072 putative Zn2+ binding site [ion binding]; other site 1294143007073 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143007074 EamA-like transporter family; Region: EamA; pfam00892 1294143007075 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1294143007076 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1294143007077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143007078 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1294143007079 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1294143007080 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1294143007081 active site 1294143007082 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1294143007083 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1294143007084 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1294143007085 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1294143007086 active site 1294143007087 Protein of unknown function (DUF454); Region: DUF454; cl01063 1294143007088 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1294143007089 heme binding pocket [chemical binding]; other site 1294143007090 heme ligand [chemical binding]; other site 1294143007091 Secretin and TonB N terminus short domain; Region: STN; smart00965 1294143007092 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1294143007093 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143007094 N-terminal plug; other site 1294143007095 ligand-binding site [chemical binding]; other site 1294143007096 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1294143007097 FecR protein; Region: FecR; pfam04773 1294143007098 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1294143007099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143007100 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1294143007101 DNA binding residues [nucleotide binding] 1294143007102 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143007103 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143007104 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1294143007105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143007106 putative substrate translocation pore; other site 1294143007107 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1294143007108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143007109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143007110 dimerization interface [polypeptide binding]; other site 1294143007111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143007112 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1294143007113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143007114 dimerization interface [polypeptide binding]; other site 1294143007115 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1294143007116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1294143007117 catalytic residue [active] 1294143007118 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1294143007119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143007120 motif II; other site 1294143007121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143007122 non-specific DNA binding site [nucleotide binding]; other site 1294143007123 salt bridge; other site 1294143007124 sequence-specific DNA binding site [nucleotide binding]; other site 1294143007125 Cupin domain; Region: Cupin_2; pfam07883 1294143007126 threonine and homoserine efflux system; Provisional; Region: PRK10532 1294143007127 EamA-like transporter family; Region: EamA; pfam00892 1294143007128 multidrug efflux protein; Reviewed; Region: PRK01766 1294143007129 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1294143007130 cation binding site [ion binding]; other site 1294143007131 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1294143007132 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1294143007133 ligand binding site [chemical binding]; other site 1294143007134 NAD binding site [chemical binding]; other site 1294143007135 catalytic site [active] 1294143007136 homodimer interface [polypeptide binding]; other site 1294143007137 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1294143007138 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1294143007139 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1294143007140 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1294143007141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143007142 NAD(P) binding site [chemical binding]; other site 1294143007143 benzoate transport; Region: 2A0115; TIGR00895 1294143007144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143007145 putative substrate translocation pore; other site 1294143007146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143007147 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143007148 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143007149 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1294143007150 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1294143007151 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1294143007152 putative alpha subunit interface [polypeptide binding]; other site 1294143007153 putative active site [active] 1294143007154 putative substrate binding site [chemical binding]; other site 1294143007155 Fe binding site [ion binding]; other site 1294143007156 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1294143007157 inter-subunit interface; other site 1294143007158 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1294143007159 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143007160 catalytic loop [active] 1294143007161 iron binding site [ion binding]; other site 1294143007162 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1294143007163 FAD binding pocket [chemical binding]; other site 1294143007164 FAD binding motif [chemical binding]; other site 1294143007165 phosphate binding motif [ion binding]; other site 1294143007166 beta-alpha-beta structure motif; other site 1294143007167 NAD binding pocket [chemical binding]; other site 1294143007168 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1294143007169 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1294143007170 putative NAD(P) binding site [chemical binding]; other site 1294143007171 active site 1294143007172 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1294143007173 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1294143007174 octamer interface [polypeptide binding]; other site 1294143007175 active site 1294143007176 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1294143007177 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1294143007178 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1294143007179 dimer interface [polypeptide binding]; other site 1294143007180 active site 1294143007181 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1294143007182 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1294143007183 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1294143007184 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143007185 dimer interface [polypeptide binding]; other site 1294143007186 active site 1294143007187 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1294143007188 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1294143007189 tetramer interface [polypeptide binding]; other site 1294143007190 active site 1294143007191 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1294143007192 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1294143007193 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1294143007194 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1294143007195 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1294143007196 acyl-activating enzyme (AAE) consensus motif; other site 1294143007197 putative AMP binding site [chemical binding]; other site 1294143007198 putative active site [active] 1294143007199 putative CoA binding site [chemical binding]; other site 1294143007200 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1294143007201 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1294143007202 active site 1294143007203 catalytic residues [active] 1294143007204 metal binding site [ion binding]; metal-binding site 1294143007205 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1294143007206 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1294143007207 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143007208 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1294143007209 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1294143007210 carboxyltransferase (CT) interaction site; other site 1294143007211 biotinylation site [posttranslational modification]; other site 1294143007212 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1294143007213 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143007214 substrate binding site [chemical binding]; other site 1294143007215 oxyanion hole (OAH) forming residues; other site 1294143007216 trimer interface [polypeptide binding]; other site 1294143007217 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1294143007218 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1294143007219 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1294143007220 isovaleryl-CoA dehydrogenase; Region: PLN02519 1294143007221 substrate binding site [chemical binding]; other site 1294143007222 FAD binding site [chemical binding]; other site 1294143007223 catalytic base [active] 1294143007224 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1294143007225 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1294143007226 DNA binding residues [nucleotide binding] 1294143007227 putative dimer interface [polypeptide binding]; other site 1294143007228 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1294143007229 GAF domain; Region: GAF; pfam01590 1294143007230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143007231 Walker A motif; other site 1294143007232 ATP binding site [chemical binding]; other site 1294143007233 Walker B motif; other site 1294143007234 arginine finger; other site 1294143007235 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143007236 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1294143007237 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143007238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143007239 Walker A/P-loop; other site 1294143007240 ATP binding site [chemical binding]; other site 1294143007241 Q-loop/lid; other site 1294143007242 ABC transporter signature motif; other site 1294143007243 Walker B; other site 1294143007244 D-loop; other site 1294143007245 H-loop/switch region; other site 1294143007246 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1294143007247 active site 1294143007248 catalytic residues [active] 1294143007249 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1294143007250 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1294143007251 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1294143007252 C-terminal domain interface [polypeptide binding]; other site 1294143007253 GSH binding site (G-site) [chemical binding]; other site 1294143007254 dimer interface [polypeptide binding]; other site 1294143007255 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1294143007256 N-terminal domain interface [polypeptide binding]; other site 1294143007257 putative dimer interface [polypeptide binding]; other site 1294143007258 active site 1294143007259 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1294143007260 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1294143007261 NAD(P) binding site [chemical binding]; other site 1294143007262 catalytic residues [active] 1294143007263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143007264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143007265 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1294143007266 putative dimerization interface [polypeptide binding]; other site 1294143007267 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1294143007268 ApbE family; Region: ApbE; pfam02424 1294143007269 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1294143007270 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1294143007271 FAD binding pocket [chemical binding]; other site 1294143007272 conserved FAD binding motif [chemical binding]; other site 1294143007273 phosphate binding motif [ion binding]; other site 1294143007274 beta-alpha-beta structure motif; other site 1294143007275 NAD binding pocket [chemical binding]; other site 1294143007276 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 1294143007277 xanthine permease; Region: pbuX; TIGR03173 1294143007278 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143007279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143007280 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1294143007281 dimerization interface [polypeptide binding]; other site 1294143007282 substrate binding pocket [chemical binding]; other site 1294143007283 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143007284 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1294143007285 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1294143007286 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1294143007287 putative active site [active] 1294143007288 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1294143007289 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143007290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143007291 Walker A/P-loop; other site 1294143007292 ATP binding site [chemical binding]; other site 1294143007293 Q-loop/lid; other site 1294143007294 ABC transporter signature motif; other site 1294143007295 Walker B; other site 1294143007296 D-loop; other site 1294143007297 H-loop/switch region; other site 1294143007298 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1294143007299 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1294143007300 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143007301 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1294143007302 amidase; Validated; Region: PRK06565 1294143007303 Amidase; Region: Amidase; cl11426 1294143007304 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143007305 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1294143007306 conserved cys residue [active] 1294143007307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143007308 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1294143007309 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1294143007310 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1294143007311 NAD(P) binding site [chemical binding]; other site 1294143007312 catalytic residues [active] 1294143007313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143007314 putative substrate translocation pore; other site 1294143007315 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1294143007316 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1294143007317 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 1294143007318 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1294143007319 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098 1294143007320 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 1294143007321 Domain of unknown function (DUF1928); Region: DUF1928; pfam09100 1294143007322 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 1294143007323 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 1294143007324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143007325 FeS/SAM binding site; other site 1294143007326 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1294143007327 Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992 1294143007328 quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907 1294143007329 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1294143007330 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1294143007331 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1294143007332 DXD motif; other site 1294143007333 Outer membrane efflux protein; Region: OEP; pfam02321 1294143007334 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143007335 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1294143007336 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143007337 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1294143007338 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1294143007339 AMP-binding domain protein; Validated; Region: PRK08315 1294143007340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143007341 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1294143007342 acyl-activating enzyme (AAE) consensus motif; other site 1294143007343 putative AMP binding site [chemical binding]; other site 1294143007344 putative active site [active] 1294143007345 putative CoA binding site [chemical binding]; other site 1294143007346 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143007347 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143007348 SurA N-terminal domain; Region: SurA_N; pfam09312 1294143007349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143007350 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1294143007351 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1294143007352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143007353 acyl-activating enzyme (AAE) consensus motif; other site 1294143007354 AMP binding site [chemical binding]; other site 1294143007355 active site 1294143007356 CoA binding site [chemical binding]; other site 1294143007357 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1294143007358 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1294143007359 NAD binding site [chemical binding]; other site 1294143007360 homodimer interface [polypeptide binding]; other site 1294143007361 homotetramer interface [polypeptide binding]; other site 1294143007362 active site 1294143007363 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1294143007364 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143007365 dimer interface [polypeptide binding]; other site 1294143007366 active site 1294143007367 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143007368 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1294143007369 FAD binding site [chemical binding]; other site 1294143007370 homotetramer interface [polypeptide binding]; other site 1294143007371 substrate binding pocket [chemical binding]; other site 1294143007372 catalytic base [active] 1294143007373 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1294143007374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143007375 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1294143007376 substrate binding pocket [chemical binding]; other site 1294143007377 dimerization interface [polypeptide binding]; other site 1294143007378 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143007379 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1294143007380 FAD binding site [chemical binding]; other site 1294143007381 substrate binding site [chemical binding]; other site 1294143007382 catalytic base [active] 1294143007383 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1294143007384 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1294143007385 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143007386 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143007387 ligand binding site [chemical binding]; other site 1294143007388 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143007389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143007390 active site 1294143007391 phosphorylation site [posttranslational modification] 1294143007392 intermolecular recognition site; other site 1294143007393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1294143007394 DNA binding residues [nucleotide binding] 1294143007395 dimerization interface [polypeptide binding]; other site 1294143007396 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1294143007397 putative catalytic site [active] 1294143007398 putative phosphate binding site [ion binding]; other site 1294143007399 active site 1294143007400 metal binding site A [ion binding]; metal-binding site 1294143007401 DNA binding site [nucleotide binding] 1294143007402 putative AP binding site [nucleotide binding]; other site 1294143007403 putative metal binding site B [ion binding]; other site 1294143007404 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1294143007405 Coenzyme A binding pocket [chemical binding]; other site 1294143007406 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1294143007407 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1294143007408 Surface antigen; Region: Bac_surface_Ag; pfam01103 1294143007409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1294143007410 Family of unknown function (DUF490); Region: DUF490; pfam04357 1294143007411 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1294143007412 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1294143007413 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1294143007414 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1294143007415 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1294143007416 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1294143007417 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1294143007418 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143007419 catalytic loop [active] 1294143007420 iron binding site [ion binding]; other site 1294143007421 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1294143007422 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1294143007423 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1294143007424 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1294143007425 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1294143007426 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1294143007427 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1294143007428 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1294143007429 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1294143007430 catalytic residues [active] 1294143007431 elongation factor G; Reviewed; Region: PRK00007 1294143007432 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1294143007433 G1 box; other site 1294143007434 putative GEF interaction site [polypeptide binding]; other site 1294143007435 GTP/Mg2+ binding site [chemical binding]; other site 1294143007436 Switch I region; other site 1294143007437 G2 box; other site 1294143007438 G3 box; other site 1294143007439 Switch II region; other site 1294143007440 G4 box; other site 1294143007441 G5 box; other site 1294143007442 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1294143007443 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1294143007444 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1294143007445 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1294143007446 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1294143007447 putative active site [active] 1294143007448 catalytic triad [active] 1294143007449 putative dimer interface [polypeptide binding]; other site 1294143007450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143007451 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1294143007452 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143007453 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1294143007454 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143007455 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1294143007456 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1294143007457 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1294143007458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143007459 Coenzyme A binding pocket [chemical binding]; other site 1294143007460 Peptidase_C39 like family; Region: DUF3335; pfam11814 1294143007461 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1294143007462 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1294143007463 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143007464 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1294143007465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143007466 Walker A motif; other site 1294143007467 ATP binding site [chemical binding]; other site 1294143007468 Walker B motif; other site 1294143007469 arginine finger; other site 1294143007470 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143007471 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1294143007472 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1294143007473 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1294143007474 putative active site [active] 1294143007475 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1294143007476 Putative esterase; Region: Esterase; pfam00756 1294143007477 outer membrane receptor FepA; Provisional; Region: PRK13524 1294143007478 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143007479 N-terminal plug; other site 1294143007480 ligand-binding site [chemical binding]; other site 1294143007481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143007482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1294143007483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143007484 dimer interface [polypeptide binding]; other site 1294143007485 phosphorylation site [posttranslational modification] 1294143007486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143007487 ATP binding site [chemical binding]; other site 1294143007488 Mg2+ binding site [ion binding]; other site 1294143007489 G-X-G motif; other site 1294143007490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1294143007491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143007492 active site 1294143007493 phosphorylation site [posttranslational modification] 1294143007494 intermolecular recognition site; other site 1294143007495 dimerization interface [polypeptide binding]; other site 1294143007496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143007497 DNA binding site [nucleotide binding] 1294143007498 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1294143007499 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1294143007500 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1294143007501 HAMP domain; Region: HAMP; pfam00672 1294143007502 dimerization interface [polypeptide binding]; other site 1294143007503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143007504 dimer interface [polypeptide binding]; other site 1294143007505 phosphorylation site [posttranslational modification] 1294143007506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143007507 ATP binding site [chemical binding]; other site 1294143007508 Mg2+ binding site [ion binding]; other site 1294143007509 G-X-G motif; other site 1294143007510 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1294143007511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143007512 active site 1294143007513 phosphorylation site [posttranslational modification] 1294143007514 intermolecular recognition site; other site 1294143007515 dimerization interface [polypeptide binding]; other site 1294143007516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143007517 DNA binding site [nucleotide binding] 1294143007518 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1294143007519 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143007520 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1294143007521 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143007522 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1294143007523 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143007524 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143007525 Cupin domain; Region: Cupin_2; cl17218 1294143007526 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1294143007527 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1294143007528 Predicted transcriptional regulator [Transcription]; Region: COG2345 1294143007529 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143007530 putative DNA binding site [nucleotide binding]; other site 1294143007531 putative Zn2+ binding site [ion binding]; other site 1294143007532 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143007533 dimerization interface [polypeptide binding]; other site 1294143007534 putative DNA binding site [nucleotide binding]; other site 1294143007535 putative Zn2+ binding site [ion binding]; other site 1294143007536 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1294143007537 putative hydrophobic ligand binding site [chemical binding]; other site 1294143007538 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1294143007539 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1294143007540 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1294143007541 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1294143007542 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1294143007543 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1294143007544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143007545 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1294143007546 putative hydrophobic ligand binding site [chemical binding]; other site 1294143007547 protein interface [polypeptide binding]; other site 1294143007548 gate; other site 1294143007549 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143007550 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143007551 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143007552 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143007553 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143007554 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1294143007555 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1294143007556 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 1294143007557 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1294143007558 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1294143007559 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1294143007560 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1294143007561 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1294143007562 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1294143007563 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143007564 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143007565 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1294143007566 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1294143007567 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1294143007568 TrkA-N domain; Region: TrkA_N; pfam02254 1294143007569 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1294143007570 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1294143007571 active site 1294143007572 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1294143007573 arsenical pump membrane protein; Provisional; Region: PRK15445 1294143007574 transmembrane helices; other site 1294143007575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143007576 dimerization interface [polypeptide binding]; other site 1294143007577 putative DNA binding site [nucleotide binding]; other site 1294143007578 putative Zn2+ binding site [ion binding]; other site 1294143007579 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1294143007580 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1294143007581 FMN binding site [chemical binding]; other site 1294143007582 substrate binding site [chemical binding]; other site 1294143007583 putative catalytic residue [active] 1294143007584 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1294143007585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143007586 S-adenosylmethionine binding site [chemical binding]; other site 1294143007587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143007588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143007589 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1294143007590 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143007591 substrate binding site [chemical binding]; other site 1294143007592 oxyanion hole (OAH) forming residues; other site 1294143007593 trimer interface [polypeptide binding]; other site 1294143007594 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1294143007595 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143007596 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143007597 acyl-activating enzyme (AAE) consensus motif; other site 1294143007598 AMP binding site [chemical binding]; other site 1294143007599 active site 1294143007600 CoA binding site [chemical binding]; other site 1294143007601 AMP-binding enzyme; Region: AMP-binding; pfam00501 1294143007602 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1294143007603 acyl-activating enzyme (AAE) consensus motif; other site 1294143007604 putative AMP binding site [chemical binding]; other site 1294143007605 putative active site [active] 1294143007606 putative CoA binding site [chemical binding]; other site 1294143007607 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1294143007608 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143007609 active site 1294143007610 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1294143007611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143007612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143007613 DNA binding residues [nucleotide binding] 1294143007614 dimerization interface [polypeptide binding]; other site 1294143007615 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1294143007616 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1294143007617 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1294143007618 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1294143007619 Surface antigen; Region: Bac_surface_Ag; pfam01103 1294143007620 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1294143007621 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143007622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143007623 active site 1294143007624 phosphorylation site [posttranslational modification] 1294143007625 intermolecular recognition site; other site 1294143007626 dimerization interface [polypeptide binding]; other site 1294143007627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143007628 DNA binding residues [nucleotide binding] 1294143007629 dimerization interface [polypeptide binding]; other site 1294143007630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143007631 PAS domain; Region: PAS_9; pfam13426 1294143007632 putative active site [active] 1294143007633 heme pocket [chemical binding]; other site 1294143007634 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143007635 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143007636 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1294143007637 MoxR-like ATPases [General function prediction only]; Region: COG0714 1294143007638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143007639 ATP binding site [chemical binding]; other site 1294143007640 Walker A motif; other site 1294143007641 Walker B motif; other site 1294143007642 arginine finger; other site 1294143007643 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1294143007644 Protein of unknown function DUF58; Region: DUF58; pfam01882 1294143007645 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1294143007646 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1294143007647 metal ion-dependent adhesion site (MIDAS); other site 1294143007648 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1294143007649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143007650 TPR motif; other site 1294143007651 binding surface 1294143007652 Oxygen tolerance; Region: BatD; pfam13584 1294143007653 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1294143007654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143007655 motif II; other site 1294143007656 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1294143007657 Sulfatase; Region: Sulfatase; pfam00884 1294143007658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1294143007659 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1294143007660 Paraquat-inducible protein A; Region: PqiA; pfam04403 1294143007661 Paraquat-inducible protein A; Region: PqiA; pfam04403 1294143007662 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1294143007663 mce related protein; Region: MCE; pfam02470 1294143007664 mce related protein; Region: MCE; pfam02470 1294143007665 mce related protein; Region: MCE; pfam02470 1294143007666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1294143007667 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1294143007668 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143007669 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143007670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143007671 choline dehydrogenase; Validated; Region: PRK02106 1294143007672 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1294143007673 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1294143007674 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143007675 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1294143007676 acyl-activating enzyme (AAE) consensus motif; other site 1294143007677 acyl-activating enzyme (AAE) consensus motif; other site 1294143007678 putative AMP binding site [chemical binding]; other site 1294143007679 putative active site [active] 1294143007680 putative CoA binding site [chemical binding]; other site 1294143007681 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1294143007682 Sulfatase; Region: Sulfatase; pfam00884 1294143007683 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143007684 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143007685 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1294143007686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143007687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143007688 DNA binding residues [nucleotide binding] 1294143007689 dimerization interface [polypeptide binding]; other site 1294143007690 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143007691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143007692 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1294143007693 putative dimerization interface [polypeptide binding]; other site 1294143007694 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1294143007695 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1294143007696 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1294143007697 active site 2 [active] 1294143007698 active site 1 [active] 1294143007699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143007700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143007701 active site 1294143007702 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1294143007703 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1294143007704 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1294143007705 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1294143007706 lipid-transfer protein; Provisional; Region: PRK08256 1294143007707 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1294143007708 active site 1294143007709 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1294143007710 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143007711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143007712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143007713 active site 1294143007714 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1294143007715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143007716 substrate binding site [chemical binding]; other site 1294143007717 oxyanion hole (OAH) forming residues; other site 1294143007718 trimer interface [polypeptide binding]; other site 1294143007719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143007720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143007721 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1294143007722 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1294143007723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143007724 DNA binding residues [nucleotide binding] 1294143007725 dimerization interface [polypeptide binding]; other site 1294143007726 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1294143007727 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1294143007728 choline dehydrogenase; Validated; Region: PRK02106 1294143007729 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1294143007730 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1294143007731 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143007732 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1294143007733 acyl-activating enzyme (AAE) consensus motif; other site 1294143007734 putative AMP binding site [chemical binding]; other site 1294143007735 putative active site [active] 1294143007736 putative CoA binding site [chemical binding]; other site 1294143007737 lipid-transfer protein; Provisional; Region: PRK08256 1294143007738 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1294143007739 active site 1294143007740 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1294143007741 active site 1294143007742 catalytic site [active] 1294143007743 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1294143007744 active site 1294143007745 catalytic site [active] 1294143007746 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1294143007747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143007748 NAD(P) binding site [chemical binding]; other site 1294143007749 active site 1294143007750 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143007751 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143007752 active site 1294143007753 enoyl-CoA hydratase; Provisional; Region: PRK06688 1294143007754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143007755 substrate binding site [chemical binding]; other site 1294143007756 oxyanion hole (OAH) forming residues; other site 1294143007757 trimer interface [polypeptide binding]; other site 1294143007758 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1294143007759 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1294143007760 NAD(P) binding site [chemical binding]; other site 1294143007761 catalytic residues [active] 1294143007762 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1294143007763 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1294143007764 NAD binding site [chemical binding]; other site 1294143007765 catalytic Zn binding site [ion binding]; other site 1294143007766 substrate binding site [chemical binding]; other site 1294143007767 structural Zn binding site [ion binding]; other site 1294143007768 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1294143007769 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1294143007770 FMN binding site [chemical binding]; other site 1294143007771 substrate binding site [chemical binding]; other site 1294143007772 putative catalytic residue [active] 1294143007773 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143007774 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1294143007775 CoenzymeA binding site [chemical binding]; other site 1294143007776 subunit interaction site [polypeptide binding]; other site 1294143007777 PHB binding site; other site 1294143007778 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1294143007779 DUF35 OB-fold domain; Region: DUF35; pfam01796 1294143007780 thiolase; Provisional; Region: PRK06158 1294143007781 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1294143007782 active site 1294143007783 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1294143007784 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143007785 active site 1294143007786 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1294143007787 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1294143007788 active site 1294143007789 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1294143007790 Ligand binding site [chemical binding]; other site 1294143007791 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1294143007792 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1294143007793 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1294143007794 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1294143007795 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 1294143007796 Int/Topo IB signature motif; other site 1294143007797 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1294143007798 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143007799 ATP binding site [chemical binding]; other site 1294143007800 putative Mg++ binding site [ion binding]; other site 1294143007801 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 1294143007802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143007803 AAA domain; Region: AAA_23; pfam13476 1294143007804 Walker A/P-loop; other site 1294143007805 ATP binding site [chemical binding]; other site 1294143007806 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 1294143007807 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 1294143007808 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143007809 TIR domain; Region: TIR_2; pfam13676 1294143007810 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1294143007811 Restriction endonuclease; Region: Mrr_cat; pfam04471 1294143007812 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1294143007813 oxyanion hole [active] 1294143007814 Domain of unknown function (DUF955); Region: DUF955; cl01076 1294143007815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143007816 non-specific DNA binding site [nucleotide binding]; other site 1294143007817 salt bridge; other site 1294143007818 sequence-specific DNA binding site [nucleotide binding]; other site 1294143007819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143007820 non-specific DNA binding site [nucleotide binding]; other site 1294143007821 salt bridge; other site 1294143007822 sequence-specific DNA binding site [nucleotide binding]; other site 1294143007823 Bacterial TniB protein; Region: TniB; pfam05621 1294143007824 Integrase core domain; Region: rve; pfam00665 1294143007825 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1294143007826 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1294143007827 DNA binding site [nucleotide binding] 1294143007828 dimer interface [polypeptide binding]; other site 1294143007829 active site 1294143007830 Int/Topo IB signature motif; other site 1294143007831 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1294143007832 LysR family transcriptional regulator; Provisional; Region: PRK14997 1294143007833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143007834 dimerization interface [polypeptide binding]; other site 1294143007835 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143007836 Pirin-related protein [General function prediction only]; Region: COG1741 1294143007837 Pirin; Region: Pirin; pfam02678 1294143007838 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1294143007839 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1294143007840 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143007841 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1294143007842 catalytic triad [active] 1294143007843 dimer interface [polypeptide binding]; other site 1294143007844 conserved cis-peptide bond; other site 1294143007845 Pirin-related protein [General function prediction only]; Region: COG1741 1294143007846 Pirin; Region: Pirin; pfam02678 1294143007847 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1294143007848 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1294143007849 LysR family transcriptional regulator; Provisional; Region: PRK14997 1294143007850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143007851 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1294143007852 putative effector binding pocket; other site 1294143007853 putative dimerization interface [polypeptide binding]; other site 1294143007854 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143007855 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1294143007856 catalytic triad [active] 1294143007857 dimer interface [polypeptide binding]; other site 1294143007858 conserved cis-peptide bond; other site 1294143007859 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1294143007860 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1294143007861 dimer interface [polypeptide binding]; other site 1294143007862 active site 1294143007863 heme binding site [chemical binding]; other site 1294143007864 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1294143007865 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1294143007866 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1294143007867 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1294143007868 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1294143007869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143007870 active site 1294143007871 motif I; other site 1294143007872 motif II; other site 1294143007873 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1294143007874 malate:quinone oxidoreductase; Validated; Region: PRK05257 1294143007875 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1294143007876 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143007877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143007878 DNA-binding site [nucleotide binding]; DNA binding site 1294143007879 FCD domain; Region: FCD; pfam07729 1294143007880 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143007881 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143007882 substrate binding pocket [chemical binding]; other site 1294143007883 membrane-bound complex binding site; other site 1294143007884 hinge residues; other site 1294143007885 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143007886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143007887 dimer interface [polypeptide binding]; other site 1294143007888 conserved gate region; other site 1294143007889 putative PBP binding loops; other site 1294143007890 ABC-ATPase subunit interface; other site 1294143007891 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1294143007892 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143007893 Walker A/P-loop; other site 1294143007894 ATP binding site [chemical binding]; other site 1294143007895 Q-loop/lid; other site 1294143007896 ABC transporter signature motif; other site 1294143007897 Walker B; other site 1294143007898 D-loop; other site 1294143007899 H-loop/switch region; other site 1294143007900 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1294143007901 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143007902 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143007903 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1294143007904 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1294143007905 RNA polymerase sigma factor; Provisional; Region: PRK12528 1294143007906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143007907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143007908 DNA binding residues [nucleotide binding] 1294143007909 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1294143007910 FecR protein; Region: FecR; pfam04773 1294143007911 Secretin and TonB N terminus short domain; Region: STN; smart00965 1294143007912 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1294143007913 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143007914 N-terminal plug; other site 1294143007915 ligand-binding site [chemical binding]; other site 1294143007916 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1294143007917 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1294143007918 RNA polymerase Rpb5, C-terminal domain; Region: RNA_pol_Rpb5_C; cl00883 1294143007919 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1294143007920 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1294143007921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143007922 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143007923 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1294143007924 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1294143007925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143007926 Walker A/P-loop; other site 1294143007927 ATP binding site [chemical binding]; other site 1294143007928 Q-loop/lid; other site 1294143007929 ABC transporter signature motif; other site 1294143007930 Walker B; other site 1294143007931 D-loop; other site 1294143007932 H-loop/switch region; other site 1294143007933 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143007934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143007935 active site 1294143007936 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143007937 Alginate lyase; Region: Alginate_lyase2; pfam08787 1294143007938 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1294143007939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1294143007940 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1294143007941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143007942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143007943 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1294143007944 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1294143007945 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1294143007946 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143007947 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143007948 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1294143007949 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143007950 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143007951 SurA N-terminal domain; Region: SurA_N; pfam09312 1294143007952 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143007953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143007954 Predicted membrane protein [Function unknown]; Region: COG2855 1294143007955 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1294143007956 iron-sulfur cluster [ion binding]; other site 1294143007957 [2Fe-2S] cluster binding site [ion binding]; other site 1294143007958 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1294143007959 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1294143007960 catalytic residues [active] 1294143007961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143007962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143007963 putative substrate translocation pore; other site 1294143007964 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1294143007965 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1294143007966 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1294143007967 substrate binding pocket [chemical binding]; other site 1294143007968 active site 1294143007969 iron coordination sites [ion binding]; other site 1294143007970 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1294143007971 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1294143007972 NADP binding site [chemical binding]; other site 1294143007973 dimer interface [polypeptide binding]; other site 1294143007974 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1294143007975 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143007976 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143007977 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1294143007978 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1294143007979 Walker A/P-loop; other site 1294143007980 ATP binding site [chemical binding]; other site 1294143007981 Q-loop/lid; other site 1294143007982 ABC transporter signature motif; other site 1294143007983 Walker B; other site 1294143007984 D-loop; other site 1294143007985 H-loop/switch region; other site 1294143007986 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1294143007987 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1294143007988 Walker A/P-loop; other site 1294143007989 ATP binding site [chemical binding]; other site 1294143007990 Q-loop/lid; other site 1294143007991 ABC transporter signature motif; other site 1294143007992 Walker B; other site 1294143007993 D-loop; other site 1294143007994 H-loop/switch region; other site 1294143007995 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143007996 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1294143007997 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143007998 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1294143007999 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1294143008000 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1294143008001 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1294143008002 SnoaL-like domain; Region: SnoaL_3; pfam13474 1294143008003 AAA domain; Region: AAA_33; pfam13671 1294143008004 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1294143008005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143008006 S-adenosylmethionine binding site [chemical binding]; other site 1294143008007 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1294143008008 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1294143008009 DEAD_2; Region: DEAD_2; pfam06733 1294143008010 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1294143008011 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1294143008012 DNA Polymerase Y-family; Region: PolY_like; cd03468 1294143008013 active site 1294143008014 DNA binding site [nucleotide binding] 1294143008015 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1294143008016 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1294143008017 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1294143008018 putative active site [active] 1294143008019 putative PHP Thumb interface [polypeptide binding]; other site 1294143008020 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1294143008021 generic binding surface I; other site 1294143008022 generic binding surface II; other site 1294143008023 hypothetical protein; Provisional; Region: PRK10040 1294143008024 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1294143008025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008026 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1294143008027 putative dimerization interface [polypeptide binding]; other site 1294143008028 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1294143008029 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1294143008030 active site 1294143008031 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1294143008032 substrate binding site [chemical binding]; other site 1294143008033 catalytic residues [active] 1294143008034 dimer interface [polypeptide binding]; other site 1294143008035 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1294143008036 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1294143008037 substrate binding pocket [chemical binding]; other site 1294143008038 Condensation domain; Region: Condensation; pfam00668 1294143008039 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1294143008040 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1294143008041 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1294143008042 acyl-activating enzyme (AAE) consensus motif; other site 1294143008043 AMP binding site [chemical binding]; other site 1294143008044 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1294143008045 Condensation domain; Region: Condensation; pfam00668 1294143008046 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1294143008047 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1294143008048 acyl-activating enzyme (AAE) consensus motif; other site 1294143008049 AMP binding site [chemical binding]; other site 1294143008050 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1294143008051 Condensation domain; Region: Condensation; pfam00668 1294143008052 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1294143008053 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1294143008054 peptide synthase; Validated; Region: PRK05691 1294143008055 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1294143008056 acyl-activating enzyme (AAE) consensus motif; other site 1294143008057 active site 1294143008058 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1294143008059 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1294143008060 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1294143008061 acyl-activating enzyme (AAE) consensus motif; other site 1294143008062 AMP binding site [chemical binding]; other site 1294143008063 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1294143008064 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1294143008065 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1294143008066 acyl-activating enzyme (AAE) consensus motif; other site 1294143008067 AMP binding site [chemical binding]; other site 1294143008068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1294143008069 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1294143008070 V-ATPase subunit C; Region: V-ATPase_C; cl15414 1294143008071 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1294143008072 acyl-activating enzyme (AAE) consensus motif; other site 1294143008073 AMP binding site [chemical binding]; other site 1294143008074 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1294143008075 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1294143008076 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1294143008077 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1294143008078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1294143008079 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1294143008080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143008081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143008082 DNA binding residues [nucleotide binding] 1294143008083 Cupin domain; Region: Cupin_2; pfam07883 1294143008084 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143008085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143008086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143008087 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1294143008088 EamA-like transporter family; Region: EamA; pfam00892 1294143008089 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1294143008090 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1294143008091 FMN binding site [chemical binding]; other site 1294143008092 substrate binding site [chemical binding]; other site 1294143008093 putative catalytic residue [active] 1294143008094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143008095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143008097 dimerization interface [polypeptide binding]; other site 1294143008098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143008099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143008100 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1294143008101 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1294143008102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143008103 DNA-binding site [nucleotide binding]; DNA binding site 1294143008104 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143008105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143008106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143008107 homodimer interface [polypeptide binding]; other site 1294143008108 catalytic residue [active] 1294143008109 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1294143008110 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1294143008111 classical (c) SDRs; Region: SDR_c; cd05233 1294143008112 NAD(P) binding site [chemical binding]; other site 1294143008113 active site 1294143008114 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1294143008115 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1294143008116 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1294143008117 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1294143008118 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1294143008119 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008120 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008121 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008122 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008123 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008124 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008125 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008126 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008127 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008128 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008129 VCBS repeat; Region: VCBS_repeat; TIGR01965 1294143008130 Outer membrane efflux protein; Region: OEP; pfam02321 1294143008131 Outer membrane efflux protein; Region: OEP; pfam02321 1294143008132 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143008133 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143008134 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143008135 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143008136 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 1294143008137 Peptidase family M50; Region: Peptidase_M50; pfam02163 1294143008138 active site 1294143008139 HlyD family secretion protein; Region: HlyD_2; pfam12700 1294143008140 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143008141 cytosine deaminase; Provisional; Region: PRK09230 1294143008142 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1294143008143 active site 1294143008144 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1294143008145 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1294143008146 cytosine permease; Provisional; Region: codB; PRK11017 1294143008147 Na binding site [ion binding]; other site 1294143008148 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1294143008149 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143008150 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1294143008151 conserved cys residue [active] 1294143008152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143008153 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143008154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143008155 putative DNA binding site [nucleotide binding]; other site 1294143008156 putative Zn2+ binding site [ion binding]; other site 1294143008157 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143008158 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1294143008159 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1294143008160 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1294143008161 tetramer interface [polypeptide binding]; other site 1294143008162 TPP-binding site [chemical binding]; other site 1294143008163 heterodimer interface [polypeptide binding]; other site 1294143008164 phosphorylation loop region [posttranslational modification] 1294143008165 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1294143008166 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1294143008167 alpha subunit interface [polypeptide binding]; other site 1294143008168 TPP binding site [chemical binding]; other site 1294143008169 heterodimer interface [polypeptide binding]; other site 1294143008170 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1294143008171 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1294143008172 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1294143008173 E3 interaction surface; other site 1294143008174 lipoyl attachment site [posttranslational modification]; other site 1294143008175 e3 binding domain; Region: E3_binding; pfam02817 1294143008176 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1294143008177 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1294143008178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143008179 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1294143008180 Cupin domain; Region: Cupin_2; pfam07883 1294143008181 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 1294143008182 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 1294143008183 Na binding site [ion binding]; other site 1294143008184 putative glycosylation site [posttranslational modification]; other site 1294143008185 putative glycosylation site [posttranslational modification]; other site 1294143008186 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1294143008187 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1294143008188 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1294143008189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1294143008190 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1294143008191 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1294143008192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143008193 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1294143008194 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143008195 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1294143008196 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1294143008197 FecR protein; Region: FecR; pfam04773 1294143008198 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1294143008199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143008200 Walker A/P-loop; other site 1294143008201 ATP binding site [chemical binding]; other site 1294143008202 ABC transporter signature motif; other site 1294143008203 Walker B; other site 1294143008204 D-loop; other site 1294143008205 H-loop/switch region; other site 1294143008206 Secretin and TonB N terminus short domain; Region: STN; smart00965 1294143008207 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1294143008208 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143008209 N-terminal plug; other site 1294143008210 ligand-binding site [chemical binding]; other site 1294143008211 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1294143008212 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1294143008213 intersubunit interface [polypeptide binding]; other site 1294143008214 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1294143008215 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1294143008216 ABC-ATPase subunit interface; other site 1294143008217 dimer interface [polypeptide binding]; other site 1294143008218 putative PBP binding regions; other site 1294143008219 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1294143008220 putative PBP binding regions; other site 1294143008221 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1294143008222 putative acyltransferase; Provisional; Region: PRK05790 1294143008223 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143008224 dimer interface [polypeptide binding]; other site 1294143008225 active site 1294143008226 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1294143008227 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1294143008228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143008229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008230 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1294143008231 putative dimerization interface [polypeptide binding]; other site 1294143008232 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1294143008233 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1294143008234 Bacterial transcriptional regulator; Region: IclR; pfam01614 1294143008235 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1294143008236 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1294143008237 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1294143008238 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1294143008239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1294143008240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1294143008241 DNA binding site [nucleotide binding] 1294143008242 domain linker motif; other site 1294143008243 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1294143008244 putative ligand binding site [chemical binding]; other site 1294143008245 putative dimerization interface [polypeptide binding]; other site 1294143008246 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1294143008247 AAA domain; Region: AAA_33; pfam13671 1294143008248 ATP-binding site [chemical binding]; other site 1294143008249 Gluconate-6-phosphate binding site [chemical binding]; other site 1294143008250 GntP family permease; Region: GntP_permease; pfam02447 1294143008251 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1294143008252 betaine aldehyde dehydrogenase; Region: PLN02467 1294143008253 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1294143008254 tetrameric interface [polypeptide binding]; other site 1294143008255 activator binding site; other site 1294143008256 NADP binding site [chemical binding]; other site 1294143008257 substrate binding site [chemical binding]; other site 1294143008258 catalytic residues [active] 1294143008259 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1294143008260 Predicted acyl esterases [General function prediction only]; Region: COG2936 1294143008261 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1294143008262 Predicted membrane protein [Function unknown]; Region: COG1288 1294143008263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143008264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008265 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1294143008266 putative dimerization interface [polypeptide binding]; other site 1294143008267 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143008268 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1294143008269 Predicted membrane protein [Function unknown]; Region: COG4392 1294143008270 EamA-like transporter family; Region: EamA; pfam00892 1294143008271 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1294143008272 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1294143008273 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1294143008274 putative heme binding pocket [chemical binding]; other site 1294143008275 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1294143008276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143008277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143008278 DNA binding residues [nucleotide binding] 1294143008279 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1294143008280 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1294143008281 active site 1294143008282 homodimer interface [polypeptide binding]; other site 1294143008283 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1294143008284 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1294143008285 salt bridge; other site 1294143008286 non-specific DNA binding site [nucleotide binding]; other site 1294143008287 Helix-turn-helix domain; Region: HTH_19; pfam12844 1294143008288 sequence-specific DNA binding site [nucleotide binding]; other site 1294143008289 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1294143008290 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1294143008291 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1294143008292 Walker A motif; other site 1294143008293 ATP binding site [chemical binding]; other site 1294143008294 Walker B motif; other site 1294143008295 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1294143008296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1294143008297 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 1294143008298 major facilitator superfamily transporter; Provisional; Region: PRK05122 1294143008299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143008300 putative substrate translocation pore; other site 1294143008301 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1294143008302 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1294143008303 Sulfatase; Region: Sulfatase; pfam00884 1294143008304 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143008305 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1294143008306 PLD-like domain; Region: PLDc_2; pfam13091 1294143008307 homodimer interface [polypeptide binding]; other site 1294143008308 putative active site [active] 1294143008309 catalytic site [active] 1294143008310 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1294143008311 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1294143008312 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1294143008313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143008314 Walker A/P-loop; other site 1294143008315 ATP binding site [chemical binding]; other site 1294143008316 Q-loop/lid; other site 1294143008317 ABC transporter signature motif; other site 1294143008318 Walker B; other site 1294143008319 D-loop; other site 1294143008320 H-loop/switch region; other site 1294143008321 ABC transporter; Region: ABC_tran_2; pfam12848 1294143008322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143008323 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1294143008324 azoreductase; Reviewed; Region: PRK00170 1294143008325 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143008326 LysR family transcriptional regulator; Provisional; Region: PRK14997 1294143008327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143008329 dimerization interface [polypeptide binding]; other site 1294143008330 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1294143008331 DNA-binding site [nucleotide binding]; DNA binding site 1294143008332 RNA-binding motif; other site 1294143008333 Predicted membrane protein [Function unknown]; Region: COG3326 1294143008334 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1294143008335 hypothetical protein; Provisional; Region: PRK09266 1294143008336 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1294143008337 substrate-cofactor binding pocket; other site 1294143008338 homodimer interface [polypeptide binding]; other site 1294143008339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143008340 catalytic residue [active] 1294143008341 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143008342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008343 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1294143008344 dimerization interface [polypeptide binding]; other site 1294143008345 substrate binding pocket [chemical binding]; other site 1294143008346 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1294143008347 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1294143008348 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1294143008349 Part of AAA domain; Region: AAA_19; pfam13245 1294143008350 Family description; Region: UvrD_C_2; pfam13538 1294143008351 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1294143008352 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1294143008353 Walker A/P-loop; other site 1294143008354 ATP binding site [chemical binding]; other site 1294143008355 Q-loop/lid; other site 1294143008356 ABC transporter signature motif; other site 1294143008357 Walker B; other site 1294143008358 D-loop; other site 1294143008359 H-loop/switch region; other site 1294143008360 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1294143008361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143008362 putative substrate translocation pore; other site 1294143008363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1294143008364 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1294143008365 active site 1294143008366 catalytic tetrad [active] 1294143008367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143008368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008369 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143008370 dimerization interface [polypeptide binding]; other site 1294143008371 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1294143008372 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1294143008373 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1294143008374 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1294143008375 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143008376 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143008377 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1294143008378 catalytic core [active] 1294143008379 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1294143008380 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1294143008381 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1294143008382 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143008383 ligand binding site [chemical binding]; other site 1294143008384 flexible hinge region; other site 1294143008385 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1294143008386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143008387 active site 1294143008388 phosphorylation site [posttranslational modification] 1294143008389 intermolecular recognition site; other site 1294143008390 dimerization interface [polypeptide binding]; other site 1294143008391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143008392 DNA binding residues [nucleotide binding] 1294143008393 dimerization interface [polypeptide binding]; other site 1294143008394 PAS fold; Region: PAS_4; pfam08448 1294143008395 PAS domain S-box; Region: sensory_box; TIGR00229 1294143008396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143008397 putative active site [active] 1294143008398 heme pocket [chemical binding]; other site 1294143008399 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1294143008400 PAS domain; Region: PAS; smart00091 1294143008401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143008402 dimer interface [polypeptide binding]; other site 1294143008403 phosphorylation site [posttranslational modification] 1294143008404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143008405 ATP binding site [chemical binding]; other site 1294143008406 Mg2+ binding site [ion binding]; other site 1294143008407 G-X-G motif; other site 1294143008408 acyl-CoA synthetase; Validated; Region: PRK08162 1294143008409 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1294143008410 acyl-activating enzyme (AAE) consensus motif; other site 1294143008411 putative active site [active] 1294143008412 AMP binding site [chemical binding]; other site 1294143008413 putative CoA binding site [chemical binding]; other site 1294143008414 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1294143008415 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143008416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143008417 active site 1294143008418 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143008419 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1294143008420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143008421 S-adenosylmethionine binding site [chemical binding]; other site 1294143008422 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143008423 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143008424 aldolase II superfamily protein; Provisional; Region: PRK07044 1294143008425 intersubunit interface [polypeptide binding]; other site 1294143008426 active site 1294143008427 Zn2+ binding site [ion binding]; other site 1294143008428 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143008429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143008430 DNA-binding site [nucleotide binding]; DNA binding site 1294143008431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143008432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143008433 homodimer interface [polypeptide binding]; other site 1294143008434 catalytic residue [active] 1294143008435 hypothetical protein; Provisional; Region: PRK12378 1294143008436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143008437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008438 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1294143008439 dimerization interface [polypeptide binding]; other site 1294143008440 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1294143008441 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1294143008442 tetrameric interface [polypeptide binding]; other site 1294143008443 NAD binding site [chemical binding]; other site 1294143008444 catalytic residues [active] 1294143008445 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1294143008446 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1294143008447 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1294143008448 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1294143008449 DNA-specific endonuclease I; Provisional; Region: PRK15137 1294143008450 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1294143008451 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1294143008452 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143008453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143008454 putative DNA binding site [nucleotide binding]; other site 1294143008455 putative Zn2+ binding site [ion binding]; other site 1294143008456 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143008457 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1294143008458 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1294143008459 glutathione reductase; Validated; Region: PRK06116 1294143008460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143008461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143008462 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1294143008463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143008464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1294143008465 active site 1294143008466 metal binding site [ion binding]; metal-binding site 1294143008467 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1294143008468 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1294143008469 active site 1294143008470 tetramer interface; other site 1294143008471 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1294143008472 Catalytic site [active] 1294143008473 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1294143008474 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143008475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143008476 active site 1294143008477 phosphorylation site [posttranslational modification] 1294143008478 intermolecular recognition site; other site 1294143008479 dimerization interface [polypeptide binding]; other site 1294143008480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143008481 DNA binding residues [nucleotide binding] 1294143008482 dimerization interface [polypeptide binding]; other site 1294143008483 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1294143008484 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1294143008485 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143008486 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143008487 ligand binding site [chemical binding]; other site 1294143008488 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1294143008489 trimer interface [polypeptide binding]; other site 1294143008490 Xylella fastidiosa surface protein related; Region: X_fast-SP_rel; pfam06669 1294143008491 Xylella fastidiosa surface protein related; Region: X_fast-SP_rel; pfam06669 1294143008492 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1294143008493 Haemagglutinin; Region: HIM; pfam05662 1294143008494 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1294143008495 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1294143008496 YadA-like C-terminal region; Region: YadA; pfam03895 1294143008497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143008498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143008499 active site 1294143008500 phosphorylation site [posttranslational modification] 1294143008501 intermolecular recognition site; other site 1294143008502 dimerization interface [polypeptide binding]; other site 1294143008503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143008504 DNA binding residues [nucleotide binding] 1294143008505 dimerization interface [polypeptide binding]; other site 1294143008506 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1294143008507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143008508 putative active site [active] 1294143008509 heme pocket [chemical binding]; other site 1294143008510 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1294143008511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143008512 ATP binding site [chemical binding]; other site 1294143008513 Mg2+ binding site [ion binding]; other site 1294143008514 G-X-G motif; other site 1294143008515 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1294143008516 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143008517 substrate binding pocket [chemical binding]; other site 1294143008518 membrane-bound complex binding site; other site 1294143008519 hinge residues; other site 1294143008520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143008521 substrate binding pocket [chemical binding]; other site 1294143008522 membrane-bound complex binding site; other site 1294143008523 hinge residues; other site 1294143008524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143008525 putative active site [active] 1294143008526 heme pocket [chemical binding]; other site 1294143008527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143008528 dimer interface [polypeptide binding]; other site 1294143008529 phosphorylation site [posttranslational modification] 1294143008530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143008531 ATP binding site [chemical binding]; other site 1294143008532 Mg2+ binding site [ion binding]; other site 1294143008533 G-X-G motif; other site 1294143008534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143008535 active site 1294143008536 phosphorylation site [posttranslational modification] 1294143008537 intermolecular recognition site; other site 1294143008538 dimerization interface [polypeptide binding]; other site 1294143008539 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143008540 putative binding surface; other site 1294143008541 active site 1294143008542 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143008543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143008544 active site 1294143008545 phosphorylation site [posttranslational modification] 1294143008546 intermolecular recognition site; other site 1294143008547 dimerization interface [polypeptide binding]; other site 1294143008548 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143008549 DNA binding residues [nucleotide binding] 1294143008550 dimerization interface [polypeptide binding]; other site 1294143008551 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1294143008552 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1294143008553 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1294143008554 GIY-YIG motif/motif A; other site 1294143008555 active site 1294143008556 catalytic site [active] 1294143008557 putative DNA binding site [nucleotide binding]; other site 1294143008558 metal binding site [ion binding]; metal-binding site 1294143008559 UvrB/uvrC motif; Region: UVR; pfam02151 1294143008560 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1294143008561 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1294143008562 DNA binding site [nucleotide binding] 1294143008563 response regulator; Provisional; Region: PRK09483 1294143008564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143008565 active site 1294143008566 phosphorylation site [posttranslational modification] 1294143008567 intermolecular recognition site; other site 1294143008568 dimerization interface [polypeptide binding]; other site 1294143008569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143008570 DNA binding residues [nucleotide binding] 1294143008571 dimerization interface [polypeptide binding]; other site 1294143008572 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1294143008573 YccA-like proteins; Region: YccA_like; cd10433 1294143008574 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1294143008575 sulfur relay protein TusC; Validated; Region: PRK00211 1294143008576 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 1294143008577 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1294143008578 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 1294143008579 hypothetical protein; Validated; Region: PRK09071 1294143008580 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1294143008581 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1294143008582 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1294143008583 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1294143008584 putative dimer interface [polypeptide binding]; other site 1294143008585 N-terminal domain interface [polypeptide binding]; other site 1294143008586 putative substrate binding pocket (H-site) [chemical binding]; other site 1294143008587 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1294143008588 siroheme synthase; Provisional; Region: cysG; PRK10637 1294143008589 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1294143008590 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1294143008591 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1294143008592 active site 1294143008593 SAM binding site [chemical binding]; other site 1294143008594 homodimer interface [polypeptide binding]; other site 1294143008595 seryl-tRNA synthetase; Provisional; Region: PRK05431 1294143008596 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1294143008597 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1294143008598 dimer interface [polypeptide binding]; other site 1294143008599 active site 1294143008600 motif 1; other site 1294143008601 motif 2; other site 1294143008602 motif 3; other site 1294143008603 recombination factor protein RarA; Reviewed; Region: PRK13342 1294143008604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143008605 Walker A motif; other site 1294143008606 ATP binding site [chemical binding]; other site 1294143008607 Walker B motif; other site 1294143008608 arginine finger; other site 1294143008609 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1294143008610 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1294143008611 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1294143008612 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1294143008613 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1294143008614 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1294143008615 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1294143008616 thioredoxin reductase; Provisional; Region: PRK10262 1294143008617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143008618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143008619 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1294143008620 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1294143008621 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1294143008622 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1294143008623 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1294143008624 rRNA binding site [nucleotide binding]; other site 1294143008625 predicted 30S ribosome binding site; other site 1294143008626 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1294143008627 Clp amino terminal domain; Region: Clp_N; pfam02861 1294143008628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143008629 Walker A motif; other site 1294143008630 ATP binding site [chemical binding]; other site 1294143008631 Walker B motif; other site 1294143008632 arginine finger; other site 1294143008633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143008634 Walker A motif; other site 1294143008635 ATP binding site [chemical binding]; other site 1294143008636 Walker B motif; other site 1294143008637 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1294143008638 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1294143008639 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1294143008640 DNA-binding site [nucleotide binding]; DNA binding site 1294143008641 RNA-binding motif; other site 1294143008642 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1294143008643 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1294143008644 isocitrate dehydrogenase; Validated; Region: PRK07362 1294143008645 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1294143008646 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1294143008647 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1294143008648 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1294143008649 nudix motif; other site 1294143008650 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1294143008651 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1294143008652 Ligand Binding Site [chemical binding]; other site 1294143008653 putative lysogenization regulator; Reviewed; Region: PRK00218 1294143008654 adenylosuccinate lyase; Provisional; Region: PRK09285 1294143008655 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1294143008656 tetramer interface [polypeptide binding]; other site 1294143008657 active site 1294143008658 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1294143008659 Cupin-like domain; Region: Cupin_8; pfam13621 1294143008660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1294143008661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143008662 Coenzyme A binding pocket [chemical binding]; other site 1294143008663 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1294143008664 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1294143008665 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1294143008666 tetramer interface [polypeptide binding]; other site 1294143008667 active site 1294143008668 Mg2+/Mn2+ binding site [ion binding]; other site 1294143008669 isocitrate lyase; Region: PLN02892 1294143008670 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143008671 CoenzymeA binding site [chemical binding]; other site 1294143008672 subunit interaction site [polypeptide binding]; other site 1294143008673 PHB binding site; other site 1294143008674 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1294143008675 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1294143008676 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1294143008677 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1294143008678 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1294143008679 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1294143008680 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1294143008681 putative dimer interface [polypeptide binding]; other site 1294143008682 [2Fe-2S] cluster binding site [ion binding]; other site 1294143008683 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1294143008684 SLBB domain; Region: SLBB; pfam10531 1294143008685 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1294143008686 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1294143008687 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143008688 catalytic loop [active] 1294143008689 iron binding site [ion binding]; other site 1294143008690 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1294143008691 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1294143008692 [4Fe-4S] binding site [ion binding]; other site 1294143008693 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1294143008694 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1294143008695 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1294143008696 4Fe-4S binding domain; Region: Fer4; pfam00037 1294143008697 4Fe-4S binding domain; Region: Fer4; pfam00037 1294143008698 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1294143008699 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1294143008700 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1294143008701 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1294143008702 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1294143008703 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1294143008704 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1294143008705 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1294143008706 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1294143008707 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1294143008708 Herpesvirus egress protein UL20; Region: Herpes_UL20; pfam04544 1294143008709 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1294143008710 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1294143008711 Predicted permease [General function prediction only]; Region: COG2056 1294143008712 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1294143008713 Cache domain; Region: Cache_1; pfam02743 1294143008714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143008715 dimerization interface [polypeptide binding]; other site 1294143008716 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143008717 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143008718 dimer interface [polypeptide binding]; other site 1294143008719 putative CheW interface [polypeptide binding]; other site 1294143008720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143008721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143008722 ATP binding site [chemical binding]; other site 1294143008723 Mg2+ binding site [ion binding]; other site 1294143008724 G-X-G motif; other site 1294143008725 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1294143008726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143008727 active site 1294143008728 phosphorylation site [posttranslational modification] 1294143008729 intermolecular recognition site; other site 1294143008730 dimerization interface [polypeptide binding]; other site 1294143008731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143008732 DNA binding site [nucleotide binding] 1294143008733 Predicted membrane protein [Function unknown]; Region: COG3212 1294143008734 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1294143008735 Predicted membrane protein [Function unknown]; Region: COG3212 1294143008736 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1294143008737 NnrS protein; Region: NnrS; pfam05940 1294143008738 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1294143008739 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1294143008740 heme-binding site [chemical binding]; other site 1294143008741 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1294143008742 FAD binding pocket [chemical binding]; other site 1294143008743 FAD binding motif [chemical binding]; other site 1294143008744 phosphate binding motif [ion binding]; other site 1294143008745 beta-alpha-beta structure motif; other site 1294143008746 NAD binding pocket [chemical binding]; other site 1294143008747 Heme binding pocket [chemical binding]; other site 1294143008748 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1294143008749 GAF domain; Region: GAF; pfam01590 1294143008750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143008751 Walker A motif; other site 1294143008752 ATP binding site [chemical binding]; other site 1294143008753 Walker B motif; other site 1294143008754 arginine finger; other site 1294143008755 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1294143008756 active site 1294143008757 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143008758 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143008759 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 1294143008760 Pirin; Region: Pirin; pfam02678 1294143008761 Pirin-related protein [General function prediction only]; Region: COG1741 1294143008762 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1294143008763 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1294143008764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143008765 putative substrate translocation pore; other site 1294143008766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143008767 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1294143008768 heat shock protein 90; Provisional; Region: PRK05218 1294143008769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143008770 ATP binding site [chemical binding]; other site 1294143008771 Mg2+ binding site [ion binding]; other site 1294143008772 G-X-G motif; other site 1294143008773 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143008774 CoenzymeA binding site [chemical binding]; other site 1294143008775 subunit interaction site [polypeptide binding]; other site 1294143008776 PHB binding site; other site 1294143008777 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143008778 CoenzymeA binding site [chemical binding]; other site 1294143008779 subunit interaction site [polypeptide binding]; other site 1294143008780 PHB binding site; other site 1294143008781 Predicted membrane protein [Function unknown]; Region: COG3821 1294143008782 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1294143008783 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1294143008784 CoA binding domain; Region: CoA_binding; pfam02629 1294143008785 CoA-ligase; Region: Ligase_CoA; pfam00549 1294143008786 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1294143008787 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1294143008788 CoA-ligase; Region: Ligase_CoA; pfam00549 1294143008789 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1294143008790 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1294143008791 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143008792 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1294143008793 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1294143008794 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1294143008795 E3 interaction surface; other site 1294143008796 lipoyl attachment site [posttranslational modification]; other site 1294143008797 e3 binding domain; Region: E3_binding; pfam02817 1294143008798 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1294143008799 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1294143008800 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1294143008801 TPP-binding site [chemical binding]; other site 1294143008802 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1294143008803 PYR/PP interface [polypeptide binding]; other site 1294143008804 dimer interface [polypeptide binding]; other site 1294143008805 TPP binding site [chemical binding]; other site 1294143008806 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1294143008807 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1294143008808 L-aspartate oxidase; Provisional; Region: PRK06175 1294143008809 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 1294143008810 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1294143008811 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1294143008812 SdhC subunit interface [polypeptide binding]; other site 1294143008813 proximal heme binding site [chemical binding]; other site 1294143008814 cardiolipin binding site; other site 1294143008815 Iron-sulfur protein interface; other site 1294143008816 proximal quinone binding site [chemical binding]; other site 1294143008817 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1294143008818 Iron-sulfur protein interface; other site 1294143008819 proximal quinone binding site [chemical binding]; other site 1294143008820 SdhD (CybS) interface [polypeptide binding]; other site 1294143008821 proximal heme binding site [chemical binding]; other site 1294143008822 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1294143008823 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1294143008824 dimer interface [polypeptide binding]; other site 1294143008825 active site 1294143008826 citrylCoA binding site [chemical binding]; other site 1294143008827 NADH binding [chemical binding]; other site 1294143008828 cationic pore residues; other site 1294143008829 oxalacetate/citrate binding site [chemical binding]; other site 1294143008830 coenzyme A binding site [chemical binding]; other site 1294143008831 catalytic triad [active] 1294143008832 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1294143008833 putative lipid binding site [chemical binding]; other site 1294143008834 Flagellin N-methylase; Region: FliB; cl00497 1294143008835 Protein of unknown function, DUF486; Region: DUF486; pfam04342 1294143008836 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1294143008837 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1294143008838 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1294143008839 active site 1294143008840 catalytic site [active] 1294143008841 substrate binding site [chemical binding]; other site 1294143008842 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1294143008843 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1294143008844 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1294143008845 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1294143008846 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1294143008847 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1294143008848 active site 1294143008849 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143008850 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143008851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143008852 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1294143008853 dimer interface [polypeptide binding]; other site 1294143008854 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143008855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1294143008856 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1294143008857 putative deacylase active site [active] 1294143008858 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1294143008859 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1294143008860 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1294143008861 V4R domain; Region: V4R; pfam02830 1294143008862 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1294143008863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143008864 Walker A motif; other site 1294143008865 ATP binding site [chemical binding]; other site 1294143008866 Walker B motif; other site 1294143008867 arginine finger; other site 1294143008868 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143008869 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1294143008870 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1294143008871 NAD(P) binding site [chemical binding]; other site 1294143008872 catalytic residues [active] 1294143008873 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1294143008874 FAD binding domain; Region: FAD_binding_4; pfam01565 1294143008875 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1294143008876 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 1294143008877 dimer interface [polypeptide binding]; other site 1294143008878 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143008879 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143008880 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1294143008881 C-terminal domain interface [polypeptide binding]; other site 1294143008882 GSH binding site (G-site) [chemical binding]; other site 1294143008883 dimer interface [polypeptide binding]; other site 1294143008884 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1294143008885 N-terminal domain interface [polypeptide binding]; other site 1294143008886 dimer interface [polypeptide binding]; other site 1294143008887 substrate binding pocket (H-site) [chemical binding]; other site 1294143008888 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1294143008889 Bacterial SH3 domain; Region: SH3_3; pfam08239 1294143008890 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1294143008891 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143008892 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1294143008893 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1294143008894 active site 1294143008895 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143008896 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1294143008897 dimer interface [polypeptide binding]; other site 1294143008898 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1294143008899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143008900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008901 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1294143008902 putative effector binding pocket; other site 1294143008903 putative dimerization interface [polypeptide binding]; other site 1294143008904 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1294143008905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143008906 NAD(P) binding site [chemical binding]; other site 1294143008907 active site 1294143008908 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1294143008909 Peptidase family U32; Region: Peptidase_U32; pfam01136 1294143008910 Collagenase; Region: DUF3656; pfam12392 1294143008911 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1294143008912 Cache domain; Region: Cache_1; pfam02743 1294143008913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143008914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143008915 metal binding site [ion binding]; metal-binding site 1294143008916 active site 1294143008917 I-site; other site 1294143008918 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1294143008919 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1294143008920 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143008921 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143008922 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1294143008923 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1294143008924 putative active site; other site 1294143008925 catalytic triad [active] 1294143008926 putative dimer interface [polypeptide binding]; other site 1294143008927 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1294143008928 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1294143008929 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143008930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008931 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143008932 dimerization interface [polypeptide binding]; other site 1294143008933 Cupin domain; Region: Cupin_2; cl17218 1294143008934 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1294143008935 DNA-binding site [nucleotide binding]; DNA binding site 1294143008936 RNA-binding motif; other site 1294143008937 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1294143008938 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1294143008939 active site 1294143008940 homotetramer interface [polypeptide binding]; other site 1294143008941 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1294143008942 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1294143008943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143008944 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1294143008945 active site 1294143008946 motif I; other site 1294143008947 motif II; other site 1294143008948 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1294143008949 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1294143008950 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1294143008951 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143008952 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143008953 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143008954 ligand binding site [chemical binding]; other site 1294143008955 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143008956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008957 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1294143008958 putative effector binding pocket; other site 1294143008959 putative dimerization interface [polypeptide binding]; other site 1294143008960 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1294143008961 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1294143008962 putative NAD(P) binding site [chemical binding]; other site 1294143008963 putative substrate binding site [chemical binding]; other site 1294143008964 catalytic Zn binding site [ion binding]; other site 1294143008965 structural Zn binding site [ion binding]; other site 1294143008966 dimer interface [polypeptide binding]; other site 1294143008967 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1294143008968 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1294143008969 active site 1294143008970 catalytic tetrad [active] 1294143008971 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1294143008972 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1294143008973 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1294143008974 active site 1294143008975 catalytic tetrad [active] 1294143008976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1294143008977 MOSC domain; Region: MOSC; pfam03473 1294143008978 3-alpha domain; Region: 3-alpha; pfam03475 1294143008979 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1294143008980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143008981 putative substrate translocation pore; other site 1294143008982 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1294143008983 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1294143008984 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1294143008985 [4Fe-4S] binding site [ion binding]; other site 1294143008986 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143008987 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143008988 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143008989 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1294143008990 molybdopterin cofactor binding site; other site 1294143008991 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1294143008992 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1294143008993 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1294143008994 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1294143008995 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1294143008996 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1294143008997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143008998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143008999 dimerization interface [polypeptide binding]; other site 1294143009000 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1294143009001 GIY-YIG motif/motif A; other site 1294143009002 active site 1294143009003 catalytic site [active] 1294143009004 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1294143009005 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1294143009006 Low-spin heme binding site [chemical binding]; other site 1294143009007 Putative water exit pathway; other site 1294143009008 Binuclear center (active site) [active] 1294143009009 Putative proton exit pathway; other site 1294143009010 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 1294143009011 HPP family; Region: HPP; pfam04982 1294143009012 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1294143009013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009015 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1294143009016 dimerization interface [polypeptide binding]; other site 1294143009017 Predicted acetyltransferase [General function prediction only]; Region: COG5628 1294143009018 SnoaL-like domain; Region: SnoaL_2; pfam12680 1294143009019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009021 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143009022 putative effector binding pocket; other site 1294143009023 dimerization interface [polypeptide binding]; other site 1294143009024 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1294143009025 classical (c) SDRs; Region: SDR_c; cd05233 1294143009026 NAD(P) binding site [chemical binding]; other site 1294143009027 active site 1294143009028 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1294143009029 active site 1 [active] 1294143009030 dimer interface [polypeptide binding]; other site 1294143009031 hexamer interface [polypeptide binding]; other site 1294143009032 active site 2 [active] 1294143009033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143009034 putative substrate translocation pore; other site 1294143009035 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1294143009036 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1294143009037 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1294143009038 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1294143009039 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143009040 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143009041 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143009042 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1294143009043 Protein export membrane protein; Region: SecD_SecF; cl14618 1294143009044 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1294143009045 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1294143009046 MgtC family; Region: MgtC; pfam02308 1294143009047 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1294143009048 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 1294143009049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1294143009050 FeS/SAM binding site; other site 1294143009051 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1294143009052 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1294143009053 magnesium transport protein MgtC; Provisional; Region: PRK15385 1294143009054 MgtC family; Region: MgtC; pfam02308 1294143009055 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143009056 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1294143009057 conserved cys residue [active] 1294143009058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143009059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143009060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143009061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009063 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1294143009064 putative substrate binding pocket [chemical binding]; other site 1294143009065 putative dimerization interface [polypeptide binding]; other site 1294143009066 DinB family; Region: DinB; cl17821 1294143009067 DinB superfamily; Region: DinB_2; pfam12867 1294143009068 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1294143009069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143009070 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1294143009071 Amidase; Region: Amidase; pfam01425 1294143009072 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1294143009073 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1294143009074 [2Fe-2S] cluster binding site [ion binding]; other site 1294143009075 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143009076 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1294143009077 dimer interface [polypeptide binding]; other site 1294143009078 active site 1294143009079 metal binding site [ion binding]; metal-binding site 1294143009080 glutathione binding site [chemical binding]; other site 1294143009081 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1294143009082 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1294143009083 [2Fe-2S] cluster binding site [ion binding]; other site 1294143009084 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1294143009085 alpha subunit interface [polypeptide binding]; other site 1294143009086 active site 1294143009087 substrate binding site [chemical binding]; other site 1294143009088 Fe binding site [ion binding]; other site 1294143009089 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143009090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009091 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1294143009092 dimerization interface [polypeptide binding]; other site 1294143009093 substrate binding pocket [chemical binding]; other site 1294143009094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143009095 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1294143009096 active site 1294143009097 benzoate transport; Region: 2A0115; TIGR00895 1294143009098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143009099 putative substrate translocation pore; other site 1294143009100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143009101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1294143009102 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1294143009103 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1294143009104 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1294143009105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143009107 dimerization interface [polypeptide binding]; other site 1294143009108 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1294143009109 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143009110 substrate binding pocket [chemical binding]; other site 1294143009111 membrane-bound complex binding site; other site 1294143009112 hinge residues; other site 1294143009113 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1294143009114 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1294143009115 Walker A/P-loop; other site 1294143009116 ATP binding site [chemical binding]; other site 1294143009117 Q-loop/lid; other site 1294143009118 ABC transporter signature motif; other site 1294143009119 Walker B; other site 1294143009120 D-loop; other site 1294143009121 H-loop/switch region; other site 1294143009122 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1294143009123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143009124 dimer interface [polypeptide binding]; other site 1294143009125 conserved gate region; other site 1294143009126 putative PBP binding loops; other site 1294143009127 ABC-ATPase subunit interface; other site 1294143009128 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 1294143009129 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1294143009130 putative active site [active] 1294143009131 metal binding site [ion binding]; metal-binding site 1294143009132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143009133 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1294143009134 putative substrate translocation pore; other site 1294143009135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009136 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1294143009137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143009138 dimerization interface [polypeptide binding]; other site 1294143009139 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1294143009140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143009141 motif II; other site 1294143009142 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1294143009143 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1294143009144 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1294143009145 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1294143009146 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1294143009147 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1294143009148 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143009149 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143009150 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143009151 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143009152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143009153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009155 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1294143009156 dimerization interface [polypeptide binding]; other site 1294143009157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009159 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1294143009160 substrate binding pocket [chemical binding]; other site 1294143009161 dimerization interface [polypeptide binding]; other site 1294143009162 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143009163 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143009164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143009165 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1294143009166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143009167 dimerization interface [polypeptide binding]; other site 1294143009168 putative Zn2+ binding site [ion binding]; other site 1294143009169 putative DNA binding site [nucleotide binding]; other site 1294143009170 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1294143009171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143009172 S-adenosylmethionine binding site [chemical binding]; other site 1294143009173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143009174 Coenzyme A binding pocket [chemical binding]; other site 1294143009175 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1294143009176 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1294143009177 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1294143009178 DctM-like transporters; Region: DctM; pfam06808 1294143009179 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 1294143009180 DctM-like transporters; Region: DctM; pfam06808 1294143009181 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1294143009182 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1294143009183 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1294143009184 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1294143009185 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1294143009186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1294143009187 DNA binding site [nucleotide binding] 1294143009188 Predicted integral membrane protein [Function unknown]; Region: COG5616 1294143009189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009191 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1294143009192 putative effector binding pocket; other site 1294143009193 putative dimerization interface [polypeptide binding]; other site 1294143009194 short chain dehydrogenase; Provisional; Region: PRK06180 1294143009195 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1294143009196 NADP binding site [chemical binding]; other site 1294143009197 active site 1294143009198 steroid binding site; other site 1294143009199 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1294143009200 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1294143009201 heme-binding site [chemical binding]; other site 1294143009202 Transposase domain (DUF772); Region: DUF772; pfam05598 1294143009203 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1294143009204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009206 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1294143009207 putative effector binding pocket; other site 1294143009208 putative dimerization interface [polypeptide binding]; other site 1294143009209 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1294143009210 dimer interface [polypeptide binding]; other site 1294143009211 FMN binding site [chemical binding]; other site 1294143009212 NADPH bind site [chemical binding]; other site 1294143009213 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1294143009214 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1294143009215 Sulfatase; Region: Sulfatase; pfam00884 1294143009216 classical (c) SDRs; Region: SDR_c; cd05233 1294143009217 NAD(P) binding site [chemical binding]; other site 1294143009218 active site 1294143009219 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1294143009220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143009221 FeS/SAM binding site; other site 1294143009222 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1294143009223 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1294143009224 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1294143009225 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143009226 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143009227 lipid-transfer protein; Provisional; Region: PRK08256 1294143009228 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1294143009229 active site 1294143009230 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1294143009231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143009232 DNA binding residues [nucleotide binding] 1294143009233 dimerization interface [polypeptide binding]; other site 1294143009234 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1294143009235 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1294143009236 mce related protein; Region: MCE; pfam02470 1294143009237 mce related protein; Region: MCE; pfam02470 1294143009238 mce related protein; Region: MCE; pfam02470 1294143009239 Paraquat-inducible protein A; Region: PqiA; pfam04403 1294143009240 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1294143009241 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1294143009242 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1294143009243 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1294143009244 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1294143009245 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143009246 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143009247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143009248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009250 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143009251 putative effector binding pocket; other site 1294143009252 dimerization interface [polypeptide binding]; other site 1294143009253 enoyl-CoA hydratase; Provisional; Region: PRK08252 1294143009254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143009255 substrate binding site [chemical binding]; other site 1294143009256 oxyanion hole (OAH) forming residues; other site 1294143009257 trimer interface [polypeptide binding]; other site 1294143009258 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1294143009259 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1294143009260 dimer interface [polypeptide binding]; other site 1294143009261 Transposase domain (DUF772); Region: DUF772; pfam05598 1294143009262 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1294143009263 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1294143009264 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1294143009265 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1294143009266 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143009267 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1294143009268 Outer membrane efflux protein; Region: OEP; pfam02321 1294143009269 potential frameshift: common BLAST hit: gi|392420669|ref|YP_006457273.1| putative transposase 1294143009270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143009271 Coenzyme A binding pocket [chemical binding]; other site 1294143009272 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1294143009273 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1294143009274 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1294143009275 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1294143009276 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1294143009277 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1294143009278 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1294143009279 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1294143009280 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1294143009281 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1294143009282 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1294143009283 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1294143009284 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1294143009285 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1294143009286 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1294143009287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143009288 Walker A motif; other site 1294143009289 ATP binding site [chemical binding]; other site 1294143009290 Walker B motif; other site 1294143009291 arginine finger; other site 1294143009292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143009293 Walker A motif; other site 1294143009294 ATP binding site [chemical binding]; other site 1294143009295 Walker B motif; other site 1294143009296 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1294143009297 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1294143009298 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1294143009299 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1294143009300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1294143009301 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1294143009302 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1294143009303 Cache domain; Region: Cache_1; pfam02743 1294143009304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143009305 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143009306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143009307 metal binding site [ion binding]; metal-binding site 1294143009308 active site 1294143009309 I-site; other site 1294143009310 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143009311 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1294143009312 catalytic triad [active] 1294143009313 dimer interface [polypeptide binding]; other site 1294143009314 conserved cis-peptide bond; other site 1294143009315 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143009316 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1294143009317 catalytic triad [active] 1294143009318 dimer interface [polypeptide binding]; other site 1294143009319 conserved cis-peptide bond; other site 1294143009320 Pirin-related protein [General function prediction only]; Region: COG1741 1294143009321 Pirin; Region: Pirin; pfam02678 1294143009322 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1294143009323 LysR family transcriptional regulator; Provisional; Region: PRK14997 1294143009324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009325 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1294143009326 putative effector binding pocket; other site 1294143009327 putative dimerization interface [polypeptide binding]; other site 1294143009328 Thermostable hemolysin; Region: T_hemolysin; pfam12261 1294143009329 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1294143009330 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143009331 acyl-activating enzyme (AAE) consensus motif; other site 1294143009332 AMP binding site [chemical binding]; other site 1294143009333 active site 1294143009334 CoA binding site [chemical binding]; other site 1294143009335 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1294143009336 heme binding pocket [chemical binding]; other site 1294143009337 heme ligand [chemical binding]; other site 1294143009338 short chain dehydrogenase; Provisional; Region: PRK09072 1294143009339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143009340 NAD(P) binding site [chemical binding]; other site 1294143009341 active site 1294143009342 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1294143009343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143009344 active site 1294143009345 phosphorylation site [posttranslational modification] 1294143009346 intermolecular recognition site; other site 1294143009347 dimerization interface [polypeptide binding]; other site 1294143009348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143009349 DNA binding site [nucleotide binding] 1294143009350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143009351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1294143009352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143009353 dimer interface [polypeptide binding]; other site 1294143009354 phosphorylation site [posttranslational modification] 1294143009355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143009356 ATP binding site [chemical binding]; other site 1294143009357 Mg2+ binding site [ion binding]; other site 1294143009358 G-X-G motif; other site 1294143009359 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 1294143009360 nudix motif; other site 1294143009361 Predicted periplasmic protein [Function unknown]; Region: COG3904 1294143009362 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1294143009363 active site 1294143009364 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1294143009365 catalytic core [active] 1294143009366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143009367 PAS fold; Region: PAS_3; pfam08447 1294143009368 putative active site [active] 1294143009369 heme pocket [chemical binding]; other site 1294143009370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143009371 metal binding site [ion binding]; metal-binding site 1294143009372 active site 1294143009373 I-site; other site 1294143009374 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1294143009375 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1294143009376 dimer interface [polypeptide binding]; other site 1294143009377 TPP-binding site [chemical binding]; other site 1294143009378 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1294143009379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1294143009380 E3 interaction surface; other site 1294143009381 lipoyl attachment site [posttranslational modification]; other site 1294143009382 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1294143009383 E3 interaction surface; other site 1294143009384 lipoyl attachment site [posttranslational modification]; other site 1294143009385 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1294143009386 E3 interaction surface; other site 1294143009387 lipoyl attachment site [posttranslational modification]; other site 1294143009388 e3 binding domain; Region: E3_binding; pfam02817 1294143009389 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1294143009390 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1294143009391 Predicted transporter component [General function prediction only]; Region: COG2391 1294143009392 Sulphur transport; Region: Sulf_transp; pfam04143 1294143009393 Predicted transporter component [General function prediction only]; Region: COG2391 1294143009394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143009395 dimerization interface [polypeptide binding]; other site 1294143009396 putative DNA binding site [nucleotide binding]; other site 1294143009397 putative Zn2+ binding site [ion binding]; other site 1294143009398 BNR repeat-like domain; Region: BNR_2; pfam13088 1294143009399 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1294143009400 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1294143009401 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143009402 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143009403 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143009404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009405 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1294143009406 dimerization interface [polypeptide binding]; other site 1294143009407 substrate binding pocket [chemical binding]; other site 1294143009408 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1294143009409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143009410 Walker A/P-loop; other site 1294143009411 ATP binding site [chemical binding]; other site 1294143009412 Q-loop/lid; other site 1294143009413 ABC transporter signature motif; other site 1294143009414 Walker B; other site 1294143009415 D-loop; other site 1294143009416 H-loop/switch region; other site 1294143009417 TOBE domain; Region: TOBE_2; pfam08402 1294143009418 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143009419 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1294143009420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143009421 dimer interface [polypeptide binding]; other site 1294143009422 conserved gate region; other site 1294143009423 putative PBP binding loops; other site 1294143009424 ABC-ATPase subunit interface; other site 1294143009425 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1294143009426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143009427 dimer interface [polypeptide binding]; other site 1294143009428 conserved gate region; other site 1294143009429 putative PBP binding loops; other site 1294143009430 ABC-ATPase subunit interface; other site 1294143009431 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1294143009432 CPxP motif; other site 1294143009433 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1294143009434 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143009435 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1294143009436 active site 1294143009437 catalytic site [active] 1294143009438 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1294143009439 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1294143009440 aconitate hydratase; Validated; Region: PRK09277 1294143009441 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1294143009442 substrate binding site [chemical binding]; other site 1294143009443 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1294143009444 ligand binding site [chemical binding]; other site 1294143009445 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1294143009446 substrate binding site [chemical binding]; other site 1294143009447 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1294143009448 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1294143009449 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1294143009450 Low-spin heme binding site [chemical binding]; other site 1294143009451 Putative water exit pathway; other site 1294143009452 Binuclear center (active site) [active] 1294143009453 Putative proton exit pathway; other site 1294143009454 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1294143009455 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1294143009456 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1294143009457 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1294143009458 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1294143009459 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143009460 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1294143009461 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1294143009462 Low-spin heme binding site [chemical binding]; other site 1294143009463 Putative water exit pathway; other site 1294143009464 Binuclear center (active site) [active] 1294143009465 Putative proton exit pathway; other site 1294143009466 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1294143009467 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1294143009468 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1294143009469 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1294143009470 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1294143009471 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143009472 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1294143009473 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1294143009474 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1294143009475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1294143009476 FixH; Region: FixH; pfam05751 1294143009477 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1294143009478 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1294143009479 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1294143009480 metal-binding site [ion binding] 1294143009481 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1294143009482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143009483 motif II; other site 1294143009484 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1294143009485 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1294143009486 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1294143009487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143009488 FeS/SAM binding site; other site 1294143009489 HemN C-terminal domain; Region: HemN_C; pfam06969 1294143009490 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1294143009491 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143009492 ligand binding site [chemical binding]; other site 1294143009493 flexible hinge region; other site 1294143009494 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1294143009495 putative switch regulator; other site 1294143009496 non-specific DNA interactions [nucleotide binding]; other site 1294143009497 DNA binding site [nucleotide binding] 1294143009498 sequence specific DNA binding site [nucleotide binding]; other site 1294143009499 putative cAMP binding site [chemical binding]; other site 1294143009500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143009501 active site 1294143009502 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1294143009503 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1294143009504 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1294143009505 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1294143009506 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1294143009507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1294143009508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143009509 short chain dehydrogenase; Provisional; Region: PRK05650 1294143009510 NAD(P) binding site [chemical binding]; other site 1294143009511 active site 1294143009512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143009513 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1294143009514 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143009515 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143009516 active site 1294143009517 recombination protein RecR; Reviewed; Region: recR; PRK00076 1294143009518 RecR protein; Region: RecR; pfam02132 1294143009519 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1294143009520 putative active site [active] 1294143009521 putative metal-binding site [ion binding]; other site 1294143009522 tetramer interface [polypeptide binding]; other site 1294143009523 hypothetical protein; Validated; Region: PRK00153 1294143009524 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1294143009525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143009526 Walker A motif; other site 1294143009527 ATP binding site [chemical binding]; other site 1294143009528 Walker B motif; other site 1294143009529 arginine finger; other site 1294143009530 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1294143009531 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143009532 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143009533 membrane-bound complex binding site; other site 1294143009534 hinge residues; other site 1294143009535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1294143009536 Transposase; Region: HTH_Tnp_1; pfam01527 1294143009537 putative transposase OrfB; Reviewed; Region: PHA02517 1294143009538 HTH-like domain; Region: HTH_21; pfam13276 1294143009539 Integrase core domain; Region: rve; pfam00665 1294143009540 Integrase core domain; Region: rve_2; pfam13333 1294143009541 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1294143009542 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1294143009543 IHF dimer interface [polypeptide binding]; other site 1294143009544 IHF - DNA interface [nucleotide binding]; other site 1294143009545 Ligase N family; Region: LIGANc; smart00532 1294143009546 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1294143009547 nucleotide binding pocket [chemical binding]; other site 1294143009548 K-X-D-G motif; other site 1294143009549 catalytic site [active] 1294143009550 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1294143009551 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1294143009552 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1294143009553 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1294143009554 Dimer interface [polypeptide binding]; other site 1294143009555 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 1294143009556 FtsZ protein binding site [polypeptide binding]; other site 1294143009557 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1294143009558 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1294143009559 Walker A/P-loop; other site 1294143009560 ATP binding site [chemical binding]; other site 1294143009561 Q-loop/lid; other site 1294143009562 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1294143009563 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1294143009564 ABC transporter signature motif; other site 1294143009565 Walker B; other site 1294143009566 D-loop; other site 1294143009567 H-loop/switch region; other site 1294143009568 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143009569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143009570 DNA-binding site [nucleotide binding]; DNA binding site 1294143009571 FCD domain; Region: FCD; cl11656 1294143009572 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1294143009573 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1294143009574 Di-iron ligands [ion binding]; other site 1294143009575 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1294143009576 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143009577 catalytic loop [active] 1294143009578 iron binding site [ion binding]; other site 1294143009579 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1294143009580 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1294143009581 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1294143009582 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1294143009583 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1294143009584 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1294143009585 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1294143009586 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1294143009587 guanine deaminase; Provisional; Region: PRK09228 1294143009588 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1294143009589 active site 1294143009590 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143009591 Ligand Binding Site [chemical binding]; other site 1294143009592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009594 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1294143009595 putative substrate binding pocket [chemical binding]; other site 1294143009596 putative dimerization interface [polypeptide binding]; other site 1294143009597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143009598 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1294143009599 putative substrate translocation pore; other site 1294143009600 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1294143009601 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143009602 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143009603 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1294143009604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143009605 DNA-binding site [nucleotide binding]; DNA binding site 1294143009606 FCD domain; Region: FCD; pfam07729 1294143009607 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1294143009608 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1294143009609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143009610 metabolite-proton symporter; Region: 2A0106; TIGR00883 1294143009611 putative substrate translocation pore; other site 1294143009612 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143009613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143009614 DNA-binding site [nucleotide binding]; DNA binding site 1294143009615 FCD domain; Region: FCD; pfam07729 1294143009616 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1294143009617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143009618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143009619 active site 1294143009620 phosphorylation site [posttranslational modification] 1294143009621 intermolecular recognition site; other site 1294143009622 dimerization interface [polypeptide binding]; other site 1294143009623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143009624 DNA binding residues [nucleotide binding] 1294143009625 dimerization interface [polypeptide binding]; other site 1294143009626 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1294143009627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143009628 putative active site [active] 1294143009629 heme pocket [chemical binding]; other site 1294143009630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143009631 ATP binding site [chemical binding]; other site 1294143009632 Mg2+ binding site [ion binding]; other site 1294143009633 G-X-G motif; other site 1294143009634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143009635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143009636 active site 1294143009637 phosphorylation site [posttranslational modification] 1294143009638 intermolecular recognition site; other site 1294143009639 dimerization interface [polypeptide binding]; other site 1294143009640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143009641 DNA binding residues [nucleotide binding] 1294143009642 dimerization interface [polypeptide binding]; other site 1294143009643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143009644 PAS domain; Region: PAS_9; pfam13426 1294143009645 putative active site [active] 1294143009646 heme pocket [chemical binding]; other site 1294143009647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143009648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143009649 ATP binding site [chemical binding]; other site 1294143009650 Mg2+ binding site [ion binding]; other site 1294143009651 G-X-G motif; other site 1294143009652 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1294143009653 active site 1294143009654 homotetramer interface [polypeptide binding]; other site 1294143009655 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1294143009656 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1294143009657 active site 1294143009658 catalytic site [active] 1294143009659 tetramer interface [polypeptide binding]; other site 1294143009660 OHCU decarboxylase; Region: UHCUDC; TIGR03164 1294143009661 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1294143009662 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1294143009663 Predicted membrane protein [Function unknown]; Region: COG3748 1294143009664 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1294143009665 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143009666 xanthine permease; Region: pbuX; TIGR03173 1294143009667 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143009668 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143009669 dimer interface [polypeptide binding]; other site 1294143009670 putative CheW interface [polypeptide binding]; other site 1294143009671 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1294143009672 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1294143009673 FMN binding site [chemical binding]; other site 1294143009674 active site 1294143009675 catalytic residues [active] 1294143009676 substrate binding site [chemical binding]; other site 1294143009677 transaldolase-like protein; Provisional; Region: PTZ00411 1294143009678 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1294143009679 active site 1294143009680 dimer interface [polypeptide binding]; other site 1294143009681 catalytic residue [active] 1294143009682 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1294143009683 anti sigma factor interaction site; other site 1294143009684 regulatory phosphorylation site [posttranslational modification]; other site 1294143009685 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143009686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143009687 active site 1294143009688 phosphorylation site [posttranslational modification] 1294143009689 intermolecular recognition site; other site 1294143009690 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1294143009691 dimerization interface [polypeptide binding]; other site 1294143009692 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1294143009693 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 1294143009694 transcriptional regulator protein; Region: phnR; TIGR03337 1294143009695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143009696 DNA-binding site [nucleotide binding]; DNA binding site 1294143009697 UTRA domain; Region: UTRA; pfam07702 1294143009698 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1294143009699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1294143009700 Zn2+ binding site [ion binding]; other site 1294143009701 Mg2+ binding site [ion binding]; other site 1294143009702 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1294143009703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1294143009704 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1294143009705 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1294143009706 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1294143009707 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1294143009708 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1294143009709 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1294143009710 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 1294143009711 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1294143009712 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1294143009713 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1294143009714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143009715 active site 1294143009716 phosphorylation site [posttranslational modification] 1294143009717 intermolecular recognition site; other site 1294143009718 dimerization interface [polypeptide binding]; other site 1294143009719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143009720 DNA binding site [nucleotide binding] 1294143009721 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1294143009722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143009723 dimerization interface [polypeptide binding]; other site 1294143009724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143009725 dimer interface [polypeptide binding]; other site 1294143009726 phosphorylation site [posttranslational modification] 1294143009727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143009728 ATP binding site [chemical binding]; other site 1294143009729 Mg2+ binding site [ion binding]; other site 1294143009730 G-X-G motif; other site 1294143009731 inner membrane transport permease; Provisional; Region: PRK15066 1294143009732 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143009733 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1294143009734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143009735 Walker A/P-loop; other site 1294143009736 ATP binding site [chemical binding]; other site 1294143009737 Q-loop/lid; other site 1294143009738 ABC transporter signature motif; other site 1294143009739 Walker B; other site 1294143009740 D-loop; other site 1294143009741 H-loop/switch region; other site 1294143009742 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143009743 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1294143009744 putative C-terminal domain interface [polypeptide binding]; other site 1294143009745 putative GSH binding site (G-site) [chemical binding]; other site 1294143009746 putative dimer interface [polypeptide binding]; other site 1294143009747 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1294143009748 putative N-terminal domain interface [polypeptide binding]; other site 1294143009749 putative dimer interface [polypeptide binding]; other site 1294143009750 putative substrate binding pocket (H-site) [chemical binding]; other site 1294143009751 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1294143009752 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1294143009753 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1294143009754 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1294143009755 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1294143009756 active site 1294143009757 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1294143009758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143009759 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143009760 DNA binding residues [nucleotide binding] 1294143009761 dimerization interface [polypeptide binding]; other site 1294143009762 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1294143009763 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1294143009764 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143009765 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143009766 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143009767 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1294143009768 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1294143009769 Walker A/P-loop; other site 1294143009770 ATP binding site [chemical binding]; other site 1294143009771 Q-loop/lid; other site 1294143009772 ABC transporter signature motif; other site 1294143009773 Walker B; other site 1294143009774 D-loop; other site 1294143009775 H-loop/switch region; other site 1294143009776 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143009777 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1294143009778 C-terminal domain interface [polypeptide binding]; other site 1294143009779 GSH binding site (G-site) [chemical binding]; other site 1294143009780 dimer interface [polypeptide binding]; other site 1294143009781 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1294143009782 N-terminal domain interface [polypeptide binding]; other site 1294143009783 dimer interface [polypeptide binding]; other site 1294143009784 substrate binding pocket (H-site) [chemical binding]; other site 1294143009785 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1294143009786 GAF domain; Region: GAF_2; pfam13185 1294143009787 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1294143009788 Protein of unknown function (DUF815); Region: DUF815; pfam05673 1294143009789 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1294143009790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143009791 ATP binding site [chemical binding]; other site 1294143009792 Mg2+ binding site [ion binding]; other site 1294143009793 G-X-G motif; other site 1294143009794 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143009795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143009796 active site 1294143009797 phosphorylation site [posttranslational modification] 1294143009798 intermolecular recognition site; other site 1294143009799 dimerization interface [polypeptide binding]; other site 1294143009800 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1294143009801 MarR family; Region: MarR; pfam01047 1294143009802 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1294143009803 catalytic residues [active] 1294143009804 dimer interface [polypeptide binding]; other site 1294143009805 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1294143009806 SelR domain; Region: SelR; pfam01641 1294143009807 aminotransferase AlaT; Validated; Region: PRK09265 1294143009808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143009809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143009810 homodimer interface [polypeptide binding]; other site 1294143009811 catalytic residue [active] 1294143009812 heat shock protein HtpX; Provisional; Region: PRK05457 1294143009813 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 1294143009814 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1294143009815 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1294143009816 putative active site [active] 1294143009817 metal binding site [ion binding]; metal-binding site 1294143009818 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1294143009819 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1294143009820 Autotransporter beta-domain; Region: Autotransporter; smart00869 1294143009821 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1294143009822 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1294143009823 ATP binding site [chemical binding]; other site 1294143009824 Mg++ binding site [ion binding]; other site 1294143009825 motif III; other site 1294143009826 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143009827 nucleotide binding region [chemical binding]; other site 1294143009828 ATP-binding site [chemical binding]; other site 1294143009829 DbpA RNA binding domain; Region: DbpA; pfam03880 1294143009830 enoyl-CoA hydratase; Provisional; Region: PRK06563 1294143009831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143009832 substrate binding site [chemical binding]; other site 1294143009833 oxyanion hole (OAH) forming residues; other site 1294143009834 trimer interface [polypeptide binding]; other site 1294143009835 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1294143009836 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1294143009837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143009838 S-adenosylmethionine binding site [chemical binding]; other site 1294143009839 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1294143009840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143009841 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1294143009842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1294143009843 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1294143009844 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 1294143009845 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1294143009846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143009849 dimerization interface [polypeptide binding]; other site 1294143009850 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1294143009851 MarR family; Region: MarR; pfam01047 1294143009852 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1294143009853 elongation factor P; Validated; Region: PRK00529 1294143009854 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1294143009855 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1294143009856 RNA binding site [nucleotide binding]; other site 1294143009857 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1294143009858 RNA binding site [nucleotide binding]; other site 1294143009859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1294143009860 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1294143009861 L,D-transpeptidase; Provisional; Region: PRK10260 1294143009862 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1294143009863 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1294143009864 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1294143009865 active site 1294143009866 catalytic triad [active] 1294143009867 oxyanion hole [active] 1294143009868 switch loop; other site 1294143009869 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1294143009870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1294143009871 Walker A/P-loop; other site 1294143009872 ATP binding site [chemical binding]; other site 1294143009873 Q-loop/lid; other site 1294143009874 ABC transporter signature motif; other site 1294143009875 Walker B; other site 1294143009876 D-loop; other site 1294143009877 H-loop/switch region; other site 1294143009878 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1294143009879 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1294143009880 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1294143009881 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1294143009882 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1294143009883 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1294143009884 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1294143009885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009886 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1294143009887 putative dimerization interface [polypeptide binding]; other site 1294143009888 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1294143009889 Predicted membrane protein [Function unknown]; Region: COG2259 1294143009890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143009891 substrate binding pocket [chemical binding]; other site 1294143009892 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1294143009893 membrane-bound complex binding site; other site 1294143009894 hinge residues; other site 1294143009895 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1294143009896 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143009897 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143009898 catalytic residue [active] 1294143009899 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1294143009900 active site 1294143009901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143009902 dimerization interface [polypeptide binding]; other site 1294143009903 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143009904 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143009905 dimer interface [polypeptide binding]; other site 1294143009906 putative CheW interface [polypeptide binding]; other site 1294143009907 Protein of unknown function (DUF962); Region: DUF962; cl01879 1294143009908 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1294143009909 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143009910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143009911 metal binding site [ion binding]; metal-binding site 1294143009912 active site 1294143009913 I-site; other site 1294143009914 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1294143009915 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1294143009916 active site 1294143009917 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 1294143009918 active site 1294143009919 dimer interface [polypeptide binding]; other site 1294143009920 CHAD domain; Region: CHAD; cl10506 1294143009921 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1294143009922 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1294143009923 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1294143009924 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1294143009925 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1294143009926 Protein of unknown function DUF58; Region: DUF58; pfam01882 1294143009927 MoxR-like ATPases [General function prediction only]; Region: COG0714 1294143009928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143009929 Walker A motif; other site 1294143009930 ATP binding site [chemical binding]; other site 1294143009931 Walker B motif; other site 1294143009932 arginine finger; other site 1294143009933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143009934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143009935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143009936 dimerization interface [polypeptide binding]; other site 1294143009937 Predicted membrane protein [Function unknown]; Region: COG4125 1294143009938 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1294143009939 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1294143009940 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1294143009941 active site 1294143009942 dimer interface [polypeptide binding]; other site 1294143009943 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1294143009944 CAAX protease self-immunity; Region: Abi; pfam02517 1294143009945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143009946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143009947 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1294143009948 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1294143009949 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1294143009950 NAD(P) binding site [chemical binding]; other site 1294143009951 substrate binding site [chemical binding]; other site 1294143009952 homotetramer interface [polypeptide binding]; other site 1294143009953 active site 1294143009954 homodimer interface [polypeptide binding]; other site 1294143009955 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1294143009956 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1294143009957 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1294143009958 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143009959 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143009960 active site 1294143009961 enoyl-CoA hydratase; Provisional; Region: PRK05995 1294143009962 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143009963 substrate binding site [chemical binding]; other site 1294143009964 oxyanion hole (OAH) forming residues; other site 1294143009965 trimer interface [polypeptide binding]; other site 1294143009966 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1294143009967 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1294143009968 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143009969 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1294143009970 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1294143009971 carboxyltransferase (CT) interaction site; other site 1294143009972 biotinylation site [posttranslational modification]; other site 1294143009973 short chain dehydrogenase; Provisional; Region: PRK08278 1294143009974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143009975 NAD(P) binding site [chemical binding]; other site 1294143009976 active site 1294143009977 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1294143009978 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143009979 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1294143009980 acyl-activating enzyme (AAE) consensus motif; other site 1294143009981 putative AMP binding site [chemical binding]; other site 1294143009982 putative active site [active] 1294143009983 putative CoA binding site [chemical binding]; other site 1294143009984 RNA polymerase sigma factor; Provisional; Region: PRK12513 1294143009985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143009986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143009987 DNA binding residues [nucleotide binding] 1294143009988 von Willebrand factor; Region: vWF_A; pfam12450 1294143009989 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1294143009990 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1294143009991 metal ion-dependent adhesion site (MIDAS); other site 1294143009992 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1294143009993 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143009994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143009995 DNA-binding site [nucleotide binding]; DNA binding site 1294143009996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143009997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143009998 homodimer interface [polypeptide binding]; other site 1294143009999 catalytic residue [active] 1294143010000 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143010001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143010002 active site 1294143010003 phosphorylation site [posttranslational modification] 1294143010004 intermolecular recognition site; other site 1294143010005 dimerization interface [polypeptide binding]; other site 1294143010006 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143010007 DNA binding residues [nucleotide binding] 1294143010008 dimerization interface [polypeptide binding]; other site 1294143010009 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143010010 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143010011 ligand binding site [chemical binding]; other site 1294143010012 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1294143010013 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1294143010014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143010015 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1294143010016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143010017 nucleophilic elbow; other site 1294143010018 catalytic triad; other site 1294143010019 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1294143010020 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1294143010021 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1294143010022 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1294143010023 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1294143010024 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1294143010025 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1294143010026 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1294143010027 Ligand binding site [chemical binding]; other site 1294143010028 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1294143010029 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1294143010030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143010031 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1294143010032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1294143010033 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1294143010034 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1294143010035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143010036 FeS/SAM binding site; other site 1294143010037 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1294143010038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143010039 FeS/SAM binding site; other site 1294143010040 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1294143010041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143010042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143010043 WHG domain; Region: WHG; pfam13305 1294143010044 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1294143010045 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1294143010046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1294143010047 catalytic residue [active] 1294143010048 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1294143010049 active site 1294143010050 PilZ domain; Region: PilZ; cl01260 1294143010051 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1294143010052 thymidylate kinase; Validated; Region: tmk; PRK00698 1294143010053 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1294143010054 TMP-binding site; other site 1294143010055 ATP-binding site [chemical binding]; other site 1294143010056 YceG-like family; Region: YceG; pfam02618 1294143010057 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1294143010058 dimerization interface [polypeptide binding]; other site 1294143010059 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1294143010060 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1294143010061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143010062 catalytic residue [active] 1294143010063 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1294143010064 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1294143010065 dimer interface [polypeptide binding]; other site 1294143010066 active site 1294143010067 acyl carrier protein; Provisional; Region: acpP; PRK00982 1294143010068 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1294143010069 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1294143010070 NAD(P) binding site [chemical binding]; other site 1294143010071 homotetramer interface [polypeptide binding]; other site 1294143010072 homodimer interface [polypeptide binding]; other site 1294143010073 active site 1294143010074 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1294143010075 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1294143010076 putative phosphate acyltransferase; Provisional; Region: PRK05331 1294143010077 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1294143010078 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1294143010079 Maf-like protein; Region: Maf; pfam02545 1294143010080 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1294143010081 active site 1294143010082 dimer interface [polypeptide binding]; other site 1294143010083 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1294143010084 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1294143010085 tandem repeat interface [polypeptide binding]; other site 1294143010086 oligomer interface [polypeptide binding]; other site 1294143010087 active site residues [active] 1294143010088 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1294143010089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143010090 motif II; other site 1294143010091 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1294143010092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1294143010093 RNA binding surface [nucleotide binding]; other site 1294143010094 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1294143010095 active site 1294143010096 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1294143010097 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1294143010098 homodimer interface [polypeptide binding]; other site 1294143010099 oligonucleotide binding site [chemical binding]; other site 1294143010100 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1294143010101 FAD binding domain; Region: FAD_binding_4; pfam01565 1294143010102 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1294143010103 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1294143010104 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1294143010105 active site 1294143010106 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1294143010107 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1294143010108 Ligand binding site; other site 1294143010109 oligomer interface; other site 1294143010110 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1294143010111 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1294143010112 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1294143010113 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1294143010114 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1294143010115 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1294143010116 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1294143010117 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1294143010118 Competence protein; Region: Competence; pfam03772 1294143010119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143010120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 1294143010121 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1294143010122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1294143010123 FtsX-like permease family; Region: FtsX; pfam02687 1294143010124 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1294143010125 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1294143010126 Walker A/P-loop; other site 1294143010127 ATP binding site [chemical binding]; other site 1294143010128 Q-loop/lid; other site 1294143010129 ABC transporter signature motif; other site 1294143010130 Walker B; other site 1294143010131 D-loop; other site 1294143010132 H-loop/switch region; other site 1294143010133 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1294143010134 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1294143010135 FtsX-like permease family; Region: FtsX; pfam02687 1294143010136 PilZ domain; Region: PilZ; pfam07238 1294143010137 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1294143010138 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1294143010139 active site 1294143010140 catalytic site [active] 1294143010141 metal binding site [ion binding]; metal-binding site 1294143010142 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1294143010143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143010144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143010145 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1294143010146 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1294143010147 ApbE family; Region: ApbE; pfam02424 1294143010148 aromatic amino acid transporter; Provisional; Region: PRK10238 1294143010149 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1294143010150 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1294143010151 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1294143010152 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1294143010153 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1294143010154 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143010155 ATP binding site [chemical binding]; other site 1294143010156 putative Mg++ binding site [ion binding]; other site 1294143010157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143010158 nucleotide binding region [chemical binding]; other site 1294143010159 ATP-binding site [chemical binding]; other site 1294143010160 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1294143010161 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1294143010162 SWIM zinc finger; Region: SWIM; pfam04434 1294143010163 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1294143010164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143010165 putative Mg++ binding site [ion binding]; other site 1294143010166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143010167 nucleotide binding region [chemical binding]; other site 1294143010168 ATP-binding site [chemical binding]; other site 1294143010169 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 1294143010170 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1294143010171 beta-hexosaminidase; Provisional; Region: PRK05337 1294143010172 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1294143010173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143010174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143010175 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1294143010176 LexA repressor; Validated; Region: PRK00215 1294143010177 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1294143010178 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1294143010179 Catalytic site [active] 1294143010180 Cell division inhibitor SulA; Region: SulA; cl01880 1294143010181 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1294143010182 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1294143010183 active site 1294143010184 interdomain interaction site; other site 1294143010185 putative metal-binding site [ion binding]; other site 1294143010186 nucleotide binding site [chemical binding]; other site 1294143010187 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1294143010188 domain I; other site 1294143010189 DNA binding groove [nucleotide binding] 1294143010190 phosphate binding site [ion binding]; other site 1294143010191 domain II; other site 1294143010192 domain III; other site 1294143010193 nucleotide binding site [chemical binding]; other site 1294143010194 catalytic site [active] 1294143010195 domain IV; other site 1294143010196 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1294143010197 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1294143010198 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1294143010199 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1294143010200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4728 1294143010201 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1294143010202 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143010203 dimer interface [polypeptide binding]; other site 1294143010204 active site 1294143010205 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1294143010206 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143010207 substrate binding site [chemical binding]; other site 1294143010208 oxyanion hole (OAH) forming residues; other site 1294143010209 trimer interface [polypeptide binding]; other site 1294143010210 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143010211 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143010212 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1294143010213 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143010214 Ligand Binding Site [chemical binding]; other site 1294143010215 ABC transporter ATPase component; Reviewed; Region: PRK11147 1294143010216 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143010217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143010218 ABC transporter; Region: ABC_tran_2; pfam12848 1294143010219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1294143010220 lytic murein transglycosylase; Provisional; Region: PRK11619 1294143010221 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143010222 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143010223 catalytic residue [active] 1294143010224 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1294143010225 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1294143010226 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1294143010227 MOSC domain; Region: MOSC; pfam03473 1294143010228 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1294143010229 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1294143010230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143010231 active site 1294143010232 phosphorylation site [posttranslational modification] 1294143010233 intermolecular recognition site; other site 1294143010234 dimerization interface [polypeptide binding]; other site 1294143010235 lipid kinase; Reviewed; Region: PRK13054 1294143010236 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1294143010237 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1294143010238 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 1294143010239 putative N- and C-terminal domain interface [polypeptide binding]; other site 1294143010240 putative active site [active] 1294143010241 MgATP binding site [chemical binding]; other site 1294143010242 catalytic site [active] 1294143010243 metal binding site [ion binding]; metal-binding site 1294143010244 putative carbohydrate binding site [chemical binding]; other site 1294143010245 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1294143010246 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1294143010247 FAD binding domain; Region: FAD_binding_4; pfam01565 1294143010248 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143010249 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143010250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143010251 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1294143010252 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1294143010253 dimer interface [polypeptide binding]; other site 1294143010254 putative functional site; other site 1294143010255 putative MPT binding site; other site 1294143010256 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1294143010257 MPT binding site; other site 1294143010258 trimer interface [polypeptide binding]; other site 1294143010259 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1294143010260 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1294143010261 GTP binding site; other site 1294143010262 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1294143010263 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1294143010264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143010265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143010266 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143010267 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1294143010268 putative C-terminal domain interface [polypeptide binding]; other site 1294143010269 putative GSH binding site (G-site) [chemical binding]; other site 1294143010270 putative dimer interface [polypeptide binding]; other site 1294143010271 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1294143010272 putative N-terminal domain interface [polypeptide binding]; other site 1294143010273 putative dimer interface [polypeptide binding]; other site 1294143010274 putative substrate binding pocket (H-site) [chemical binding]; other site 1294143010275 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1294143010276 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143010277 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143010278 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1294143010279 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1294143010280 Predicted membrane protein [Function unknown]; Region: COG5393 1294143010281 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143010282 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1294143010283 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1294143010284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1294143010285 Zn2+ binding site [ion binding]; other site 1294143010286 Mg2+ binding site [ion binding]; other site 1294143010287 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1294143010288 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1294143010289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143010290 substrate binding pocket [chemical binding]; other site 1294143010291 membrane-bound complex binding site; other site 1294143010292 hinge residues; other site 1294143010293 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143010294 substrate binding pocket [chemical binding]; other site 1294143010295 membrane-bound complex binding site; other site 1294143010296 hinge residues; other site 1294143010297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143010298 putative active site [active] 1294143010299 heme pocket [chemical binding]; other site 1294143010300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143010301 dimer interface [polypeptide binding]; other site 1294143010302 phosphorylation site [posttranslational modification] 1294143010303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143010304 ATP binding site [chemical binding]; other site 1294143010305 Mg2+ binding site [ion binding]; other site 1294143010306 G-X-G motif; other site 1294143010307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143010308 active site 1294143010309 phosphorylation site [posttranslational modification] 1294143010310 intermolecular recognition site; other site 1294143010311 dimerization interface [polypeptide binding]; other site 1294143010312 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143010313 putative binding surface; other site 1294143010314 active site 1294143010315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143010316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143010317 active site 1294143010318 phosphorylation site [posttranslational modification] 1294143010319 intermolecular recognition site; other site 1294143010320 dimerization interface [polypeptide binding]; other site 1294143010321 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143010322 DNA binding residues [nucleotide binding] 1294143010323 dimerization interface [polypeptide binding]; other site 1294143010324 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1294143010325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1294143010326 active site 1294143010327 phosphorylation site [posttranslational modification] 1294143010328 intermolecular recognition site; other site 1294143010329 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1294143010330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143010331 active site 1294143010332 phosphorylation site [posttranslational modification] 1294143010333 intermolecular recognition site; other site 1294143010334 dimerization interface [polypeptide binding]; other site 1294143010335 Protein with unknown function (DUF469); Region: DUF469; cl01237 1294143010336 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1294143010337 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1294143010338 CHASE domain; Region: CHASE; pfam03924 1294143010339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143010340 PAS fold; Region: PAS_3; pfam08447 1294143010341 putative active site [active] 1294143010342 heme pocket [chemical binding]; other site 1294143010343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143010344 PAS domain; Region: PAS_9; pfam13426 1294143010345 putative active site [active] 1294143010346 heme pocket [chemical binding]; other site 1294143010347 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143010348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143010349 metal binding site [ion binding]; metal-binding site 1294143010350 active site 1294143010351 I-site; other site 1294143010352 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1294143010353 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1294143010354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1294143010355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143010356 S-adenosylmethionine binding site [chemical binding]; other site 1294143010357 Ribosome modulation factor [Translation, ribosomal structure and biogenesis]; Region: Rmf; COG3130 1294143010358 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1294143010359 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1294143010360 quinone interaction residues [chemical binding]; other site 1294143010361 active site 1294143010362 catalytic residues [active] 1294143010363 FMN binding site [chemical binding]; other site 1294143010364 substrate binding site [chemical binding]; other site 1294143010365 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1294143010366 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143010367 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143010368 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1294143010369 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1294143010370 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1294143010371 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143010372 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143010373 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1294143010374 MoxR-like ATPases [General function prediction only]; Region: COG0714 1294143010375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143010376 Walker A motif; other site 1294143010377 ATP binding site [chemical binding]; other site 1294143010378 Walker B motif; other site 1294143010379 arginine finger; other site 1294143010380 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1294143010381 Protein of unknown function DUF58; Region: DUF58; pfam01882 1294143010382 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1294143010383 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1294143010384 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1294143010385 metal ion-dependent adhesion site (MIDAS); other site 1294143010386 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1294143010387 metal ion-dependent adhesion site (MIDAS); other site 1294143010388 TPR repeat; Region: TPR_11; pfam13414 1294143010389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143010390 binding surface 1294143010391 Oxygen tolerance; Region: BatD; pfam13584 1294143010392 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1294143010393 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1294143010394 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143010395 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143010396 aminopeptidase N; Provisional; Region: pepN; PRK14015 1294143010397 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1294143010398 active site 1294143010399 Zn binding site [ion binding]; other site 1294143010400 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1294143010401 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 1294143010402 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 1294143010403 Rhomboid family; Region: Rhomboid; pfam01694 1294143010404 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 1294143010405 active site 1294143010406 metal binding site [ion binding]; metal-binding site 1294143010407 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 1294143010408 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1294143010409 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 1294143010410 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1294143010411 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1294143010412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1294143010413 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1294143010414 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1294143010415 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1294143010416 active site 1294143010417 FMN binding site [chemical binding]; other site 1294143010418 2,4-decadienoyl-CoA binding site; other site 1294143010419 catalytic residue [active] 1294143010420 4Fe-4S cluster binding site [ion binding]; other site 1294143010421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1294143010422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143010423 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1294143010424 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1294143010425 active site 1294143010426 catalytic triad [active] 1294143010427 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143010428 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143010429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143010430 oxidoreductase; Validated; Region: PRK05717 1294143010431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143010432 NAD(P) binding site [chemical binding]; other site 1294143010433 active site 1294143010434 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1294143010435 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1294143010436 homodimer interface [polypeptide binding]; other site 1294143010437 substrate-cofactor binding pocket; other site 1294143010438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143010439 catalytic residue [active] 1294143010440 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1294143010441 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1294143010442 active site 1294143010443 tetramer interface [polypeptide binding]; other site 1294143010444 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143010445 active site 1294143010446 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1294143010447 Colicin V production protein; Region: Colicin_V; cl00567 1294143010448 Sporulation related domain; Region: SPOR; pfam05036 1294143010449 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1294143010450 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1294143010451 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1294143010452 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1294143010453 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1294143010454 active site 1294143010455 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1294143010456 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1294143010457 dimerization interface 3.5A [polypeptide binding]; other site 1294143010458 active site 1294143010459 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1294143010460 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143010461 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1294143010462 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1294143010463 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1294143010464 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143010465 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1294143010466 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1294143010467 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1294143010468 tartrate dehydrogenase; Region: TTC; TIGR02089 1294143010469 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1294143010470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143010471 S-adenosylmethionine binding site [chemical binding]; other site 1294143010472 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1294143010473 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1294143010474 substrate binding site [chemical binding]; other site 1294143010475 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1294143010476 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1294143010477 substrate binding site [chemical binding]; other site 1294143010478 ligand binding site [chemical binding]; other site 1294143010479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143010480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143010481 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143010482 dimerization interface [polypeptide binding]; other site 1294143010483 PAS domain S-box; Region: sensory_box; TIGR00229 1294143010484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143010485 putative active site [active] 1294143010486 heme pocket [chemical binding]; other site 1294143010487 PAS fold; Region: PAS_3; pfam08447 1294143010488 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1294143010489 PAS domain S-box; Region: sensory_box; TIGR00229 1294143010490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143010491 putative active site [active] 1294143010492 heme pocket [chemical binding]; other site 1294143010493 PAS domain S-box; Region: sensory_box; TIGR00229 1294143010494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143010495 putative active site [active] 1294143010496 heme pocket [chemical binding]; other site 1294143010497 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143010498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143010499 metal binding site [ion binding]; metal-binding site 1294143010500 active site 1294143010501 I-site; other site 1294143010502 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143010503 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1294143010504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143010505 non-specific DNA binding site [nucleotide binding]; other site 1294143010506 salt bridge; other site 1294143010507 sequence-specific DNA binding site [nucleotide binding]; other site 1294143010508 Cupin domain; Region: Cupin_2; pfam07883 1294143010509 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143010510 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1294143010511 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1294143010512 homotrimer interaction site [polypeptide binding]; other site 1294143010513 putative active site [active] 1294143010514 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1294143010515 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1294143010516 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1294143010517 putative dimer interface [polypeptide binding]; other site 1294143010518 short chain dehydrogenase; Provisional; Region: PRK06123 1294143010519 classical (c) SDRs; Region: SDR_c; cd05233 1294143010520 NAD(P) binding site [chemical binding]; other site 1294143010521 active site 1294143010522 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1294143010523 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1294143010524 FMN binding site [chemical binding]; other site 1294143010525 active site 1294143010526 catalytic residues [active] 1294143010527 substrate binding site [chemical binding]; other site 1294143010528 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1294143010529 active site 1294143010530 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1294143010531 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1294143010532 active site 1294143010533 intersubunit interface [polypeptide binding]; other site 1294143010534 catalytic residue [active] 1294143010535 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143010536 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143010537 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1294143010538 nucleophilic elbow; other site 1294143010539 catalytic triad; other site 1294143010540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143010541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143010542 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1294143010543 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1294143010544 HIGH motif; other site 1294143010545 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1294143010546 active site 1294143010547 KMSKS motif; other site 1294143010548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143010549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143010550 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143010551 putative effector binding pocket; other site 1294143010552 dimerization interface [polypeptide binding]; other site 1294143010553 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1294143010554 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143010555 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143010556 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1294143010557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143010558 putative substrate translocation pore; other site 1294143010559 excinuclease ABC subunit B; Provisional; Region: PRK05298 1294143010560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143010561 ATP binding site [chemical binding]; other site 1294143010562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143010563 nucleotide binding region [chemical binding]; other site 1294143010564 ATP-binding site [chemical binding]; other site 1294143010565 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1294143010566 UvrB/uvrC motif; Region: UVR; pfam02151 1294143010567 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1294143010568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143010569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143010570 homodimer interface [polypeptide binding]; other site 1294143010571 catalytic residue [active] 1294143010572 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1294143010573 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1294143010574 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1294143010575 CoA binding domain; Region: CoA_binding; cl17356 1294143010576 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1294143010577 NAD(P) binding site [chemical binding]; other site 1294143010578 homodimer interface [polypeptide binding]; other site 1294143010579 substrate binding site [chemical binding]; other site 1294143010580 active site 1294143010581 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1294143010582 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1294143010583 Mg++ binding site [ion binding]; other site 1294143010584 putative catalytic motif [active] 1294143010585 putative substrate binding site [chemical binding]; other site 1294143010586 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1294143010587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143010588 NAD(P) binding site [chemical binding]; other site 1294143010589 active site 1294143010590 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1294143010591 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1294143010592 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1294143010593 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1294143010594 IHF dimer interface [polypeptide binding]; other site 1294143010595 IHF - DNA interface [nucleotide binding]; other site 1294143010596 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1294143010597 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143010598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143010599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143010600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143010601 dimerization interface [polypeptide binding]; other site 1294143010602 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143010603 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1294143010604 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1294143010605 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1294143010606 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1294143010607 substrate binding site [chemical binding]; other site 1294143010608 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1294143010609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143010610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143010611 Walker A/P-loop; other site 1294143010612 ATP binding site [chemical binding]; other site 1294143010613 Q-loop/lid; other site 1294143010614 ABC transporter signature motif; other site 1294143010615 Walker B; other site 1294143010616 D-loop; other site 1294143010617 H-loop/switch region; other site 1294143010618 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1294143010619 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1294143010620 active site 1294143010621 intersubunit interface [polypeptide binding]; other site 1294143010622 catalytic residue [active] 1294143010623 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1294143010624 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1294143010625 putative active site [active] 1294143010626 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1294143010627 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1294143010628 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1294143010629 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1294143010630 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1294143010631 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1294143010632 putative active site [active] 1294143010633 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1294143010634 active site 1294143010635 phosphate binding residues; other site 1294143010636 catalytic residues [active] 1294143010637 glucokinase, proteobacterial type; Region: glk; TIGR00749 1294143010638 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1294143010639 nucleotide binding site [chemical binding]; other site 1294143010640 phosphogluconate dehydratase; Validated; Region: PRK09054 1294143010641 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1294143010642 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1294143010643 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1294143010644 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1294143010645 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1294143010646 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1294143010647 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1294143010648 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1294143010649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143010650 Coenzyme A binding pocket [chemical binding]; other site 1294143010651 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1294143010652 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1294143010653 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1294143010654 active site 1294143010655 HIGH motif; other site 1294143010656 dimer interface [polypeptide binding]; other site 1294143010657 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1294143010658 active site 1294143010659 KMSKS motif; other site 1294143010660 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1294143010661 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1294143010662 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1294143010663 active site 1294143010664 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1294143010665 intracellular septation protein A; Reviewed; Region: PRK00259 1294143010666 YciI-like protein; Reviewed; Region: PRK11370 1294143010667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1294143010668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143010669 active site 1294143010670 phosphorylation site [posttranslational modification] 1294143010671 intermolecular recognition site; other site 1294143010672 dimerization interface [polypeptide binding]; other site 1294143010673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143010674 DNA binding site [nucleotide binding] 1294143010675 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1294143010676 dimer interface [polypeptide binding]; other site 1294143010677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143010678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1294143010679 dimerization interface [polypeptide binding]; other site 1294143010680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143010681 ATP binding site [chemical binding]; other site 1294143010682 G-X-G motif; other site 1294143010683 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1294143010684 putative FMN binding site [chemical binding]; other site 1294143010685 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1294143010686 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1294143010687 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143010688 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143010689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143010690 Predicted membrane protein [Function unknown]; Region: COG4323 1294143010691 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1294143010692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143010693 ATP binding site [chemical binding]; other site 1294143010694 putative Mg++ binding site [ion binding]; other site 1294143010695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143010696 nucleotide binding region [chemical binding]; other site 1294143010697 ATP-binding site [chemical binding]; other site 1294143010698 DEAD/H associated; Region: DEAD_assoc; pfam08494 1294143010699 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1294143010700 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1294143010701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143010702 putative active site [active] 1294143010703 heme pocket [chemical binding]; other site 1294143010704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143010705 Walker A motif; other site 1294143010706 ATP binding site [chemical binding]; other site 1294143010707 Walker B motif; other site 1294143010708 arginine finger; other site 1294143010709 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1294143010710 cofactor binding site; other site 1294143010711 metal binding site [ion binding]; metal-binding site 1294143010712 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1294143010713 aromatic arch; other site 1294143010714 DCoH dimer interaction site [polypeptide binding]; other site 1294143010715 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1294143010716 DCoH tetramer interaction site [polypeptide binding]; other site 1294143010717 substrate binding site [chemical binding]; other site 1294143010718 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1294143010719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143010720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143010721 homodimer interface [polypeptide binding]; other site 1294143010722 catalytic residue [active] 1294143010723 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1294143010724 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1294143010725 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1294143010726 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1294143010727 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1294143010728 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1294143010729 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1294143010730 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1294143010731 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1294143010732 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1294143010733 Walker A motif; other site 1294143010734 ATP binding site [chemical binding]; other site 1294143010735 Walker B motif; other site 1294143010736 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1294143010737 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1294143010738 cytidylate kinase; Provisional; Region: cmk; PRK00023 1294143010739 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1294143010740 CMP-binding site; other site 1294143010741 The sites determining sugar specificity; other site 1294143010742 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1294143010743 prephenate dehydrogenase; Validated; Region: PRK08507 1294143010744 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1294143010745 hinge; other site 1294143010746 active site 1294143010747 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1294143010748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143010749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143010750 homodimer interface [polypeptide binding]; other site 1294143010751 catalytic residue [active] 1294143010752 Chorismate mutase type II; Region: CM_2; cl00693 1294143010753 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1294143010754 Prephenate dehydratase; Region: PDT; pfam00800 1294143010755 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1294143010756 putative L-Phe binding site [chemical binding]; other site 1294143010757 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1294143010758 homodimer interface [polypeptide binding]; other site 1294143010759 substrate-cofactor binding pocket; other site 1294143010760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143010761 catalytic residue [active] 1294143010762 DNA gyrase subunit A; Validated; Region: PRK05560 1294143010763 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1294143010764 CAP-like domain; other site 1294143010765 active site 1294143010766 primary dimer interface [polypeptide binding]; other site 1294143010767 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1294143010768 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1294143010769 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1294143010770 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1294143010771 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1294143010772 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1294143010773 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1294143010774 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1294143010775 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1294143010776 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1294143010777 active site 1294143010778 putative substrate binding pocket [chemical binding]; other site 1294143010779 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1294143010780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143010781 S-adenosylmethionine binding site [chemical binding]; other site 1294143010782 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1294143010783 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1294143010784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143010785 motif II; other site 1294143010786 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1294143010787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143010788 NAD(P) binding site [chemical binding]; other site 1294143010789 active site 1294143010790 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143010791 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143010792 metal binding site [ion binding]; metal-binding site 1294143010793 active site 1294143010794 I-site; other site 1294143010795 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1294143010796 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1294143010797 RNA binding surface [nucleotide binding]; other site 1294143010798 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1294143010799 probable active site [active] 1294143010800 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1294143010801 nudix motif; other site 1294143010802 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1294143010803 Low-spin heme binding site [chemical binding]; other site 1294143010804 Putative water exit pathway; other site 1294143010805 Binuclear center (active site) [active] 1294143010806 Putative proton exit pathway; other site 1294143010807 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 1294143010808 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1294143010809 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1294143010810 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1294143010811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143010812 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1294143010813 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1294143010814 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1294143010815 putative active site [active] 1294143010816 putative metal binding site [ion binding]; other site 1294143010817 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143010818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143010819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143010820 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1294143010821 dimer interface [polypeptide binding]; other site 1294143010822 putative tRNA-binding site [nucleotide binding]; other site 1294143010823 EamA-like transporter family; Region: EamA; pfam00892 1294143010824 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1294143010825 EamA-like transporter family; Region: EamA; pfam00892 1294143010826 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1294143010827 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1294143010828 NADP binding site [chemical binding]; other site 1294143010829 homopentamer interface [polypeptide binding]; other site 1294143010830 substrate binding site [chemical binding]; other site 1294143010831 active site 1294143010832 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1294143010833 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1294143010834 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1294143010835 active site 1294143010836 nucleophile elbow; other site 1294143010837 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1294143010838 Surface antigen; Region: Bac_surface_Ag; pfam01103 1294143010839 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1294143010840 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143010841 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1294143010842 transcriptional regulator SlyA; Provisional; Region: PRK03573 1294143010843 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1294143010844 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 1294143010845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143010846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143010847 metal binding site [ion binding]; metal-binding site 1294143010848 active site 1294143010849 I-site; other site 1294143010850 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1294143010851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143010852 ATP binding site [chemical binding]; other site 1294143010853 putative Mg++ binding site [ion binding]; other site 1294143010854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143010855 nucleotide binding region [chemical binding]; other site 1294143010856 ATP-binding site [chemical binding]; other site 1294143010857 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1294143010858 HRDC domain; Region: HRDC; pfam00570 1294143010859 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1294143010860 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1294143010861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1294143010862 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1294143010863 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143010864 dimerization interface [polypeptide binding]; other site 1294143010865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143010866 dimer interface [polypeptide binding]; other site 1294143010867 phosphorylation site [posttranslational modification] 1294143010868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143010869 ATP binding site [chemical binding]; other site 1294143010870 Mg2+ binding site [ion binding]; other site 1294143010871 G-X-G motif; other site 1294143010872 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1294143010873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143010874 active site 1294143010875 phosphorylation site [posttranslational modification] 1294143010876 intermolecular recognition site; other site 1294143010877 dimerization interface [polypeptide binding]; other site 1294143010878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143010879 DNA binding site [nucleotide binding] 1294143010880 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1294143010881 Protein export membrane protein; Region: SecD_SecF; cl14618 1294143010882 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143010883 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143010884 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143010885 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1294143010886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143010887 dimerization interface [polypeptide binding]; other site 1294143010888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143010889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143010890 metal binding site [ion binding]; metal-binding site 1294143010891 active site 1294143010892 I-site; other site 1294143010893 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143010894 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1294143010895 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1294143010896 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1294143010897 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1294143010898 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1294143010899 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1294143010900 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1294143010901 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1294143010902 active site 1294143010903 dimer interface [polypeptide binding]; other site 1294143010904 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1294143010905 Ligand Binding Site [chemical binding]; other site 1294143010906 Molecular Tunnel; other site 1294143010907 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1294143010908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143010909 Coenzyme A binding pocket [chemical binding]; other site 1294143010910 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143010911 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1294143010912 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1294143010913 putative oligomer interface [polypeptide binding]; other site 1294143010914 putative active site [active] 1294143010915 metal binding site [ion binding]; metal-binding site 1294143010916 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 1294143010917 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1294143010918 short chain dehydrogenase; Provisional; Region: PRK05650 1294143010919 classical (c) SDRs; Region: SDR_c; cd05233 1294143010920 NAD(P) binding site [chemical binding]; other site 1294143010921 active site 1294143010922 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1294143010923 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1294143010924 active site 1294143010925 catalytic site [active] 1294143010926 substrate binding site [chemical binding]; other site 1294143010927 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1294143010928 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143010929 ligand binding site [chemical binding]; other site 1294143010930 flexible hinge region; other site 1294143010931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 1294143010932 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1294143010933 metal binding triad; other site 1294143010934 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1294143010935 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1294143010936 Na binding site [ion binding]; other site 1294143010937 Predicted membrane protein [Function unknown]; Region: COG3162 1294143010938 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1294143010939 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1294143010940 Predicted membrane protein [Function unknown]; Region: COG3205 1294143010941 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1294143010942 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1294143010943 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143010944 VacJ like lipoprotein; Region: VacJ; cl01073 1294143010945 Pirin-related protein [General function prediction only]; Region: COG1741 1294143010946 Pirin; Region: Pirin; pfam02678 1294143010947 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1294143010948 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1294143010949 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1294143010950 active site 1294143010951 nucleophile elbow; other site 1294143010952 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1294143010953 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1294143010954 putative acyl-acceptor binding pocket; other site 1294143010955 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1294143010956 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1294143010957 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1294143010958 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1294143010959 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1294143010960 Switch I; other site 1294143010961 Switch II; other site 1294143010962 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1294143010963 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1294143010964 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1294143010965 active site 1294143010966 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1294143010967 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1294143010968 active site 1294143010969 metal binding site [ion binding]; metal-binding site 1294143010970 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1294143010971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143010972 DNA-binding site [nucleotide binding]; DNA binding site 1294143010973 transcriptional regulator protein; Region: phnR; TIGR03337 1294143010974 UTRA domain; Region: UTRA; pfam07702 1294143010975 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143010976 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143010977 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1294143010978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143010979 dimer interface [polypeptide binding]; other site 1294143010980 conserved gate region; other site 1294143010981 putative PBP binding loops; other site 1294143010982 ABC-ATPase subunit interface; other site 1294143010983 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1294143010984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143010985 dimer interface [polypeptide binding]; other site 1294143010986 conserved gate region; other site 1294143010987 putative PBP binding loops; other site 1294143010988 ABC-ATPase subunit interface; other site 1294143010989 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1294143010990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143010991 Walker A/P-loop; other site 1294143010992 ATP binding site [chemical binding]; other site 1294143010993 Q-loop/lid; other site 1294143010994 ABC transporter signature motif; other site 1294143010995 Walker B; other site 1294143010996 D-loop; other site 1294143010997 H-loop/switch region; other site 1294143010998 TOBE domain; Region: TOBE_2; pfam08402 1294143010999 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1294143011000 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1294143011001 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1294143011002 Peptidase family M50; Region: Peptidase_M50; pfam02163 1294143011003 active site 1294143011004 putative substrate binding region [chemical binding]; other site 1294143011005 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1294143011006 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1294143011007 NAD(P) binding site [chemical binding]; other site 1294143011008 carboxy-terminal protease; Provisional; Region: PRK11186 1294143011009 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1294143011010 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1294143011011 protein binding site [polypeptide binding]; other site 1294143011012 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1294143011013 Catalytic dyad [active] 1294143011014 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1294143011015 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143011016 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1294143011017 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143011018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143011019 metal binding site [ion binding]; metal-binding site 1294143011020 active site 1294143011021 I-site; other site 1294143011022 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1294143011023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143011024 non-specific DNA binding site [nucleotide binding]; other site 1294143011025 salt bridge; other site 1294143011026 sequence-specific DNA binding site [nucleotide binding]; other site 1294143011027 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1294143011028 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1294143011029 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1294143011030 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1294143011031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1294143011032 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1294143011033 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1294143011034 Sodium Bile acid symporter family; Region: SBF; pfam01758 1294143011035 multidrug efflux system protein; Provisional; Region: PRK11431 1294143011036 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1294143011037 DNA-binding site [nucleotide binding]; DNA binding site 1294143011038 RNA-binding motif; other site 1294143011039 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1294143011040 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1294143011041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1294143011042 putative acyl-acceptor binding pocket; other site 1294143011043 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1294143011044 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143011045 N-terminal plug; other site 1294143011046 ligand-binding site [chemical binding]; other site 1294143011047 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143011048 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143011049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143011050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143011051 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1294143011052 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1294143011053 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1294143011054 Na binding site [ion binding]; other site 1294143011055 PAS domain; Region: PAS; smart00091 1294143011056 PAS fold; Region: PAS_7; pfam12860 1294143011057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1294143011058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143011059 dimer interface [polypeptide binding]; other site 1294143011060 phosphorylation site [posttranslational modification] 1294143011061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143011062 ATP binding site [chemical binding]; other site 1294143011063 Mg2+ binding site [ion binding]; other site 1294143011064 G-X-G motif; other site 1294143011065 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143011066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143011067 active site 1294143011068 phosphorylation site [posttranslational modification] 1294143011069 intermolecular recognition site; other site 1294143011070 dimerization interface [polypeptide binding]; other site 1294143011071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1294143011072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143011073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143011074 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 1294143011075 putative substrate binding pocket [chemical binding]; other site 1294143011076 putative dimerization interface [polypeptide binding]; other site 1294143011077 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1294143011078 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1294143011079 DNA binding residues [nucleotide binding] 1294143011080 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1294143011081 active site 1294143011082 short chain dehydrogenase; Validated; Region: PRK05855 1294143011083 classical (c) SDRs; Region: SDR_c; cd05233 1294143011084 NAD(P) binding site [chemical binding]; other site 1294143011085 active site 1294143011086 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1294143011087 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1294143011088 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143011089 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1294143011090 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1294143011091 RmuC family; Region: RmuC; pfam02646 1294143011092 RES domain; Region: RES; smart00953 1294143011093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143011094 salt bridge; other site 1294143011095 non-specific DNA binding site [nucleotide binding]; other site 1294143011096 sequence-specific DNA binding site [nucleotide binding]; other site 1294143011097 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1294143011098 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1294143011099 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1294143011100 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1294143011101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143011102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143011103 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1294143011104 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1294143011105 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1294143011106 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 1294143011107 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 1294143011108 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143011109 putative active site [active] 1294143011110 putative metal binding site [ion binding]; other site 1294143011111 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1294143011112 putative FMN binding site [chemical binding]; other site 1294143011113 benzoate transport; Region: 2A0115; TIGR00895 1294143011114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143011115 putative substrate translocation pore; other site 1294143011116 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1294143011117 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1294143011118 tetrameric interface [polypeptide binding]; other site 1294143011119 NAD binding site [chemical binding]; other site 1294143011120 catalytic residues [active] 1294143011121 potential protein location (hypothetical protein H681_17700 [Pseudomonas denitrificans ATCC 13867]) that overlaps RNA (tRNA-S) 1294143011122 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1294143011123 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1294143011124 ATP binding site [chemical binding]; other site 1294143011125 active site 1294143011126 substrate binding site [chemical binding]; other site 1294143011127 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1294143011128 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1294143011129 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1294143011130 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1294143011131 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1294143011132 dimer interface [polypeptide binding]; other site 1294143011133 active site 1294143011134 catalytic residue [active] 1294143011135 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1294143011136 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1294143011137 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1294143011138 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1294143011139 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1294143011140 catalytic triad [active] 1294143011141 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1294143011142 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1294143011143 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1294143011144 CPxP motif; other site 1294143011145 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1294143011146 Peptidase family M48; Region: Peptidase_M48; cl12018 1294143011147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1294143011148 TPR motif; other site 1294143011149 binding surface 1294143011150 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1294143011151 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1294143011152 quinolinate synthetase; Provisional; Region: PRK09375 1294143011153 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1294143011154 Ligand Binding Site [chemical binding]; other site 1294143011155 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1294143011156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143011157 FeS/SAM binding site; other site 1294143011158 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1294143011159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143011160 binding surface 1294143011161 TPR motif; other site 1294143011162 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1294143011163 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143011164 ligand binding site [chemical binding]; other site 1294143011165 translocation protein TolB; Provisional; Region: tolB; PRK00178 1294143011166 TolB amino-terminal domain; Region: TolB_N; pfam04052 1294143011167 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1294143011168 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1294143011169 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1294143011170 TolA protein; Region: tolA_full; TIGR02794 1294143011171 TolA protein; Region: tolA_full; TIGR02794 1294143011172 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1294143011173 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1294143011174 TolR protein; Region: tolR; TIGR02801 1294143011175 TolQ protein; Region: tolQ; TIGR02796 1294143011176 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1294143011177 active site 1294143011178 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1294143011179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143011180 Walker A motif; other site 1294143011181 ATP binding site [chemical binding]; other site 1294143011182 Walker B motif; other site 1294143011183 arginine finger; other site 1294143011184 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1294143011185 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1294143011186 RuvA N terminal domain; Region: RuvA_N; pfam01330 1294143011187 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1294143011188 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1294143011189 active site 1294143011190 putative DNA-binding cleft [nucleotide binding]; other site 1294143011191 dimer interface [polypeptide binding]; other site 1294143011192 hypothetical protein; Validated; Region: PRK00110 1294143011193 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1294143011194 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1294143011195 dimer interface [polypeptide binding]; other site 1294143011196 anticodon binding site; other site 1294143011197 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1294143011198 homodimer interface [polypeptide binding]; other site 1294143011199 motif 1; other site 1294143011200 active site 1294143011201 motif 2; other site 1294143011202 GAD domain; Region: GAD; pfam02938 1294143011203 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1294143011204 active site 1294143011205 motif 3; other site 1294143011206 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1294143011207 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1294143011208 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1294143011209 dimerization interface [polypeptide binding]; other site 1294143011210 DPS ferroxidase diiron center [ion binding]; other site 1294143011211 ion pore; other site 1294143011212 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1294143011213 DNA-binding site [nucleotide binding]; DNA binding site 1294143011214 RNA-binding motif; other site 1294143011215 hypothetical protein; Provisional; Region: PRK00295 1294143011216 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1294143011217 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143011218 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143011219 CoenzymeA binding site [chemical binding]; other site 1294143011220 subunit interaction site [polypeptide binding]; other site 1294143011221 PHB binding site; other site 1294143011222 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1294143011223 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1294143011224 dimer interface [polypeptide binding]; other site 1294143011225 motif 1; other site 1294143011226 active site 1294143011227 motif 2; other site 1294143011228 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1294143011229 putative deacylase active site [active] 1294143011230 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1294143011231 active site 1294143011232 motif 3; other site 1294143011233 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1294143011234 anticodon binding site; other site 1294143011235 acylphosphatase; Provisional; Region: PRK14442 1294143011236 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1294143011237 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1294143011238 catalytic residues [active] 1294143011239 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1294143011240 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 1294143011241 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1294143011242 ArsC family; Region: ArsC; pfam03960 1294143011243 catalytic residues [active] 1294143011244 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1294143011245 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143011246 Predicted membrane protein [Function unknown]; Region: COG3308 1294143011247 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1294143011248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143011249 Walker A motif; other site 1294143011250 ATP binding site [chemical binding]; other site 1294143011251 Walker B motif; other site 1294143011252 arginine finger; other site 1294143011253 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1294143011254 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1294143011255 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1294143011256 dimerization interface [polypeptide binding]; other site 1294143011257 putative ATP binding site [chemical binding]; other site 1294143011258 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1294143011259 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1294143011260 active site 1294143011261 substrate binding site [chemical binding]; other site 1294143011262 cosubstrate binding site; other site 1294143011263 catalytic site [active] 1294143011264 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1294143011265 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 1294143011266 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1294143011267 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1294143011268 catalytic residues [active] 1294143011269 dimer interface [polypeptide binding]; other site 1294143011270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143011271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143011272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1294143011273 MarR family; Region: MarR; pfam01047 1294143011274 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1294143011275 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143011276 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143011277 active site 1294143011278 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143011279 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1294143011280 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1294143011281 catalytic core [active] 1294143011282 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1294143011283 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1294143011284 putative dimer interface [polypeptide binding]; other site 1294143011285 active site pocket [active] 1294143011286 putative cataytic base [active] 1294143011287 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1294143011288 homotrimer interface [polypeptide binding]; other site 1294143011289 Walker A motif; other site 1294143011290 GTP binding site [chemical binding]; other site 1294143011291 Walker B motif; other site 1294143011292 cobyric acid synthase; Provisional; Region: PRK00784 1294143011293 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1294143011294 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1294143011295 catalytic triad [active] 1294143011296 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1294143011297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143011298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143011299 homodimer interface [polypeptide binding]; other site 1294143011300 catalytic residue [active] 1294143011301 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1294143011302 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1294143011303 FMN binding site [chemical binding]; other site 1294143011304 dimer interface [polypeptide binding]; other site 1294143011305 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1294143011306 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1294143011307 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1294143011308 catalytic triad [active] 1294143011309 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1294143011310 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1294143011311 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1294143011312 homodimer interface [polypeptide binding]; other site 1294143011313 Walker A motif; other site 1294143011314 ATP binding site [chemical binding]; other site 1294143011315 hydroxycobalamin binding site [chemical binding]; other site 1294143011316 Walker B motif; other site 1294143011317 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 1294143011318 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143011319 N-terminal plug; other site 1294143011320 ligand-binding site [chemical binding]; other site 1294143011321 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1294143011322 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1294143011323 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1294143011324 Permease; Region: Permease; pfam02405 1294143011325 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1294143011326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143011327 Walker A/P-loop; other site 1294143011328 ATP binding site [chemical binding]; other site 1294143011329 Q-loop/lid; other site 1294143011330 ABC transporter signature motif; other site 1294143011331 Walker B; other site 1294143011332 D-loop; other site 1294143011333 H-loop/switch region; other site 1294143011334 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1294143011335 mce related protein; Region: MCE; pfam02470 1294143011336 Protein of unknown function (DUF330); Region: DUF330; cl01135 1294143011337 D-cysteine desulfhydrase; Validated; Region: PRK03910 1294143011338 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1294143011339 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1294143011340 catalytic residue [active] 1294143011341 cystine transporter subunit; Provisional; Region: PRK11260 1294143011342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143011343 substrate binding pocket [chemical binding]; other site 1294143011344 membrane-bound complex binding site; other site 1294143011345 hinge residues; other site 1294143011346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143011347 dimer interface [polypeptide binding]; other site 1294143011348 conserved gate region; other site 1294143011349 putative PBP binding loops; other site 1294143011350 ABC-ATPase subunit interface; other site 1294143011351 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1294143011352 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143011353 Walker A/P-loop; other site 1294143011354 ATP binding site [chemical binding]; other site 1294143011355 Q-loop/lid; other site 1294143011356 ABC transporter signature motif; other site 1294143011357 Walker B; other site 1294143011358 D-loop; other site 1294143011359 H-loop/switch region; other site 1294143011360 Pirin-related protein [General function prediction only]; Region: COG1741 1294143011361 Pirin; Region: Pirin; pfam02678 1294143011362 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1294143011363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143011364 S-adenosylmethionine binding site [chemical binding]; other site 1294143011365 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1294143011366 NlpC/P60 family; Region: NLPC_P60; pfam00877 1294143011367 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1294143011368 NlpC/P60 family; Region: NLPC_P60; pfam00877 1294143011369 NAD-dependent deacetylase; Provisional; Region: PRK00481 1294143011370 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1294143011371 NAD+ binding site [chemical binding]; other site 1294143011372 substrate binding site [chemical binding]; other site 1294143011373 Zn binding site [ion binding]; other site 1294143011374 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 1294143011375 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1294143011376 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1294143011377 Ligand Binding Site [chemical binding]; other site 1294143011378 DNA-J related protein; Region: DNAJ_related; pfam12339 1294143011379 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1294143011380 HSP70 interaction site [polypeptide binding]; other site 1294143011381 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1294143011382 hypothetical protein; Provisional; Region: PRK04860 1294143011383 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1294143011384 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1294143011385 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1294143011386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143011387 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143011388 active site 1294143011389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1294143011390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143011391 Coenzyme A binding pocket [chemical binding]; other site 1294143011392 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1294143011393 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1294143011394 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1294143011395 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1294143011396 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1294143011397 active site residue [active] 1294143011398 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1294143011399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1294143011400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1294143011401 DNA binding residues [nucleotide binding] 1294143011402 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1294143011403 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1294143011404 dimer interface [polypeptide binding]; other site 1294143011405 active site 1294143011406 CoA binding pocket [chemical binding]; other site 1294143011407 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1294143011408 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1294143011409 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1294143011410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143011411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143011412 metal binding site [ion binding]; metal-binding site 1294143011413 active site 1294143011414 I-site; other site 1294143011415 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1294143011416 HIT family signature motif; other site 1294143011417 catalytic residue [active] 1294143011418 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143011419 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1294143011420 C-terminal domain interface [polypeptide binding]; other site 1294143011421 GSH binding site (G-site) [chemical binding]; other site 1294143011422 dimer interface [polypeptide binding]; other site 1294143011423 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1294143011424 dimer interface [polypeptide binding]; other site 1294143011425 N-terminal domain interface [polypeptide binding]; other site 1294143011426 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1294143011427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143011428 ATP binding site [chemical binding]; other site 1294143011429 putative Mg++ binding site [ion binding]; other site 1294143011430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143011431 nucleotide binding region [chemical binding]; other site 1294143011432 ATP-binding site [chemical binding]; other site 1294143011433 Helicase associated domain (HA2); Region: HA2; pfam04408 1294143011434 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1294143011435 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1294143011436 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1294143011437 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143011438 dimerization interface [polypeptide binding]; other site 1294143011439 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143011440 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143011441 dimer interface [polypeptide binding]; other site 1294143011442 putative CheW interface [polypeptide binding]; other site 1294143011443 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1294143011444 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1294143011445 acyl-activating enzyme (AAE) consensus motif; other site 1294143011446 putative AMP binding site [chemical binding]; other site 1294143011447 putative active site [active] 1294143011448 putative CoA binding site [chemical binding]; other site 1294143011449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 1294143011450 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 1294143011451 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1294143011452 acyl-activating enzyme (AAE) consensus motif; other site 1294143011453 putative AMP binding site [chemical binding]; other site 1294143011454 putative active site [active] 1294143011455 putative CoA binding site [chemical binding]; other site 1294143011456 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1294143011457 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143011458 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1294143011459 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1294143011460 dimer interaction site [polypeptide binding]; other site 1294143011461 substrate-binding tunnel; other site 1294143011462 active site 1294143011463 catalytic site [active] 1294143011464 substrate binding site [chemical binding]; other site 1294143011465 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1294143011466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143011467 putative substrate translocation pore; other site 1294143011468 HlyD family secretion protein; Region: HlyD; pfam00529 1294143011469 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143011470 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143011471 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1294143011472 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1294143011473 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1294143011474 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1294143011475 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1294143011476 ATP-dependent helicase HepA; Validated; Region: PRK04914 1294143011477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143011478 ATP binding site [chemical binding]; other site 1294143011479 putative Mg++ binding site [ion binding]; other site 1294143011480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143011481 nucleotide binding region [chemical binding]; other site 1294143011482 ATP-binding site [chemical binding]; other site 1294143011483 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143011484 Ligand Binding Site [chemical binding]; other site 1294143011485 putative metal dependent hydrolase; Provisional; Region: PRK11598 1294143011486 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1294143011487 Sulfatase; Region: Sulfatase; pfam00884 1294143011488 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1294143011489 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1294143011490 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1294143011491 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143011492 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143011493 metal binding site [ion binding]; metal-binding site 1294143011494 active site 1294143011495 I-site; other site 1294143011496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143011497 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1294143011498 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1294143011499 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1294143011500 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1294143011501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143011502 substrate binding pocket [chemical binding]; other site 1294143011503 membrane-bound complex binding site; other site 1294143011504 hinge residues; other site 1294143011505 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1294143011506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143011507 Walker A/P-loop; other site 1294143011508 ATP binding site [chemical binding]; other site 1294143011509 Q-loop/lid; other site 1294143011510 ABC transporter signature motif; other site 1294143011511 Walker B; other site 1294143011512 D-loop; other site 1294143011513 H-loop/switch region; other site 1294143011514 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1294143011515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143011516 dimer interface [polypeptide binding]; other site 1294143011517 conserved gate region; other site 1294143011518 putative PBP binding loops; other site 1294143011519 ABC-ATPase subunit interface; other site 1294143011520 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1294143011521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143011522 dimer interface [polypeptide binding]; other site 1294143011523 conserved gate region; other site 1294143011524 putative PBP binding loops; other site 1294143011525 ABC-ATPase subunit interface; other site 1294143011526 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1294143011527 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1294143011528 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1294143011529 dimerization interface [polypeptide binding]; other site 1294143011530 ligand binding site [chemical binding]; other site 1294143011531 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1294143011532 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1294143011533 TM-ABC transporter signature motif; other site 1294143011534 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1294143011535 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1294143011536 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1294143011537 TM-ABC transporter signature motif; other site 1294143011538 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1294143011539 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1294143011540 Walker A/P-loop; other site 1294143011541 ATP binding site [chemical binding]; other site 1294143011542 Q-loop/lid; other site 1294143011543 ABC transporter signature motif; other site 1294143011544 Walker B; other site 1294143011545 D-loop; other site 1294143011546 H-loop/switch region; other site 1294143011547 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1294143011548 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1294143011549 Walker A/P-loop; other site 1294143011550 ATP binding site [chemical binding]; other site 1294143011551 Q-loop/lid; other site 1294143011552 ABC transporter signature motif; other site 1294143011553 Walker B; other site 1294143011554 D-loop; other site 1294143011555 H-loop/switch region; other site 1294143011556 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1294143011557 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143011558 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143011559 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143011560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143011561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143011562 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1294143011563 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1294143011564 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1294143011565 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1294143011566 tetramer interface [polypeptide binding]; other site 1294143011567 active site 1294143011568 Mg2+/Mn2+ binding site [ion binding]; other site 1294143011569 Protein of unknown function DUF72; Region: DUF72; cl00777 1294143011570 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1294143011571 Glycoprotease family; Region: Peptidase_M22; pfam00814 1294143011572 adenylate kinase; Reviewed; Region: adk; PRK00279 1294143011573 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1294143011574 AMP-binding site [chemical binding]; other site 1294143011575 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1294143011576 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1294143011577 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1294143011578 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1294143011579 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1294143011580 DNA binding residues [nucleotide binding] 1294143011581 dimer interface [polypeptide binding]; other site 1294143011582 putative metal binding site [ion binding]; other site 1294143011583 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1294143011584 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1294143011585 metal-binding site [ion binding] 1294143011586 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1294143011587 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1294143011588 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1294143011589 putative ADP-ribose binding site [chemical binding]; other site 1294143011590 putative active site [active] 1294143011591 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143011592 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1294143011593 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1294143011594 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1294143011595 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1294143011596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1294143011597 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1294143011598 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1294143011599 dimer interface [polypeptide binding]; other site 1294143011600 putative anticodon binding site; other site 1294143011601 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1294143011602 motif 1; other site 1294143011603 active site 1294143011604 motif 2; other site 1294143011605 motif 3; other site 1294143011606 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1294143011607 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1294143011608 RF-1 domain; Region: RF-1; pfam00472 1294143011609 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143011610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143011611 active site 1294143011612 phosphorylation site [posttranslational modification] 1294143011613 intermolecular recognition site; other site 1294143011614 dimerization interface [polypeptide binding]; other site 1294143011615 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143011616 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143011617 metal binding site [ion binding]; metal-binding site 1294143011618 active site 1294143011619 I-site; other site 1294143011620 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1294143011621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143011622 active site 1294143011623 phosphorylation site [posttranslational modification] 1294143011624 intermolecular recognition site; other site 1294143011625 CheB methylesterase; Region: CheB_methylest; pfam01339 1294143011626 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1294143011627 putative binding surface; other site 1294143011628 active site 1294143011629 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1294143011630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143011631 ATP binding site [chemical binding]; other site 1294143011632 Mg2+ binding site [ion binding]; other site 1294143011633 G-X-G motif; other site 1294143011634 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1294143011635 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143011636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143011637 active site 1294143011638 phosphorylation site [posttranslational modification] 1294143011639 intermolecular recognition site; other site 1294143011640 dimerization interface [polypeptide binding]; other site 1294143011641 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1294143011642 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1294143011643 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1294143011644 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1294143011645 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1294143011646 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1294143011647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143011648 dimerization interface [polypeptide binding]; other site 1294143011649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143011650 dimer interface [polypeptide binding]; other site 1294143011651 putative CheW interface [polypeptide binding]; other site 1294143011652 Predicted membrane protein [Function unknown]; Region: COG1238 1294143011653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143011654 putative substrate translocation pore; other site 1294143011655 choline dehydrogenase; Validated; Region: PRK02106 1294143011656 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1294143011657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143011658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143011659 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143011660 dimerization interface [polypeptide binding]; other site 1294143011661 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 1294143011662 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1294143011663 secondary substrate binding site; other site 1294143011664 primary substrate binding site; other site 1294143011665 inhibition loop; other site 1294143011666 dimerization interface [polypeptide binding]; other site 1294143011667 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1294143011668 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1294143011669 putative metal binding site [ion binding]; other site 1294143011670 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1294143011671 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1294143011672 putative metal binding site [ion binding]; other site 1294143011673 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1294143011674 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1294143011675 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1294143011676 catalytic Zn binding site [ion binding]; other site 1294143011677 structural Zn binding site [ion binding]; other site 1294143011678 NAD(P) binding site [chemical binding]; other site 1294143011679 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1294143011680 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1294143011681 active site 1294143011682 FMN binding site [chemical binding]; other site 1294143011683 substrate binding site [chemical binding]; other site 1294143011684 homotetramer interface [polypeptide binding]; other site 1294143011685 catalytic residue [active] 1294143011686 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1294143011687 putative DNA binding helix; other site 1294143011688 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1294143011689 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1294143011690 Na binding site [ion binding]; other site 1294143011691 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143011692 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143011693 active site 1294143011694 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1294143011695 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1294143011696 urocanate hydratase; Provisional; Region: PRK05414 1294143011697 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1294143011698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143011699 DNA-binding site [nucleotide binding]; DNA binding site 1294143011700 UTRA domain; Region: UTRA; pfam07702 1294143011701 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1294143011702 DHH family; Region: DHH; pfam01368 1294143011703 DHHA1 domain; Region: DHHA1; pfam02272 1294143011704 YaeQ protein; Region: YaeQ; pfam07152 1294143011705 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143011706 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143011707 metal binding site [ion binding]; metal-binding site 1294143011708 active site 1294143011709 I-site; other site 1294143011710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1294143011711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1294143011712 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1294143011713 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1294143011714 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1294143011715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143011716 catalytic residue [active] 1294143011717 homoserine dehydrogenase; Provisional; Region: PRK06349 1294143011718 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1294143011719 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1294143011720 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1294143011721 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1294143011722 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1294143011723 dimerization domain [polypeptide binding]; other site 1294143011724 dimer interface [polypeptide binding]; other site 1294143011725 catalytic residues [active] 1294143011726 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1294143011727 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1294143011728 active site 1294143011729 Int/Topo IB signature motif; other site 1294143011730 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1294143011731 TrkA-N domain; Region: TrkA_N; pfam02254 1294143011732 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1294143011733 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1294143011734 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1294143011735 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1294143011736 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1294143011737 RimM N-terminal domain; Region: RimM; pfam01782 1294143011738 PRC-barrel domain; Region: PRC; pfam05239 1294143011739 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1294143011740 signal recognition particle protein; Provisional; Region: PRK10867 1294143011741 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1294143011742 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1294143011743 P loop; other site 1294143011744 GTP binding site [chemical binding]; other site 1294143011745 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1294143011746 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1294143011747 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1294143011748 Domain of unknown function DUF21; Region: DUF21; pfam01595 1294143011749 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1294143011750 Transporter associated domain; Region: CorC_HlyC; smart01091 1294143011751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143011752 metabolite-proton symporter; Region: 2A0106; TIGR00883 1294143011753 putative substrate translocation pore; other site 1294143011754 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1294143011755 active site 1294143011756 catalytic triad [active] 1294143011757 oxyanion hole [active] 1294143011758 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1294143011759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143011760 ATP-grasp domain; Region: ATP-grasp; pfam02222 1294143011761 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1294143011762 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1294143011763 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1294143011764 trimer interface [polypeptide binding]; other site 1294143011765 putative metal binding site [ion binding]; other site 1294143011766 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1294143011767 putative active site [active] 1294143011768 putative CoA binding site [chemical binding]; other site 1294143011769 nudix motif; other site 1294143011770 metal binding site [ion binding]; metal-binding site 1294143011771 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1294143011772 nudix motif; other site 1294143011773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1294143011774 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1294143011775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1294143011776 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1294143011777 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1294143011778 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1294143011779 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1294143011780 dimerization interface [polypeptide binding]; other site 1294143011781 ATP binding site [chemical binding]; other site 1294143011782 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1294143011783 dimerization interface [polypeptide binding]; other site 1294143011784 ATP binding site [chemical binding]; other site 1294143011785 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1294143011786 putative active site [active] 1294143011787 catalytic triad [active] 1294143011788 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1294143011789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143011790 substrate binding pocket [chemical binding]; other site 1294143011791 membrane-bound complex binding site; other site 1294143011792 hinge residues; other site 1294143011793 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1294143011794 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1294143011795 catalytic residue [active] 1294143011796 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1294143011797 nucleoside/Zn binding site; other site 1294143011798 dimer interface [polypeptide binding]; other site 1294143011799 catalytic motif [active] 1294143011800 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1294143011801 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1294143011802 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1294143011803 GMP synthase; Reviewed; Region: guaA; PRK00074 1294143011804 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1294143011805 AMP/PPi binding site [chemical binding]; other site 1294143011806 candidate oxyanion hole; other site 1294143011807 catalytic triad [active] 1294143011808 potential glutamine specificity residues [chemical binding]; other site 1294143011809 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1294143011810 ATP Binding subdomain [chemical binding]; other site 1294143011811 Dimerization subdomain; other site 1294143011812 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1294143011813 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1294143011814 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1294143011815 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1294143011816 active site 1294143011817 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1294143011818 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1294143011819 generic binding surface II; other site 1294143011820 generic binding surface I; other site 1294143011821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143011822 dimerization interface [polypeptide binding]; other site 1294143011823 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1294143011824 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1294143011825 Peptidase family M23; Region: Peptidase_M23; pfam01551 1294143011826 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1294143011827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143011828 Coenzyme A binding pocket [chemical binding]; other site 1294143011829 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1294143011830 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1294143011831 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1294143011832 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1294143011833 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1294143011834 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1294143011835 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1294143011836 N-terminal plug; other site 1294143011837 ligand-binding site [chemical binding]; other site 1294143011838 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1294143011839 2-isopropylmalate synthase; Validated; Region: PRK03739 1294143011840 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1294143011841 active site 1294143011842 catalytic residues [active] 1294143011843 metal binding site [ion binding]; metal-binding site 1294143011844 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1294143011845 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 1294143011846 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1294143011847 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1294143011848 dimer interface [polypeptide binding]; other site 1294143011849 active site 1294143011850 catalytic residue [active] 1294143011851 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1294143011852 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1294143011853 active site 1294143011854 catalytic tetrad [active] 1294143011855 C-N hydrolase family amidase; Provisional; Region: PRK10438 1294143011856 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1294143011857 putative active site [active] 1294143011858 catalytic triad [active] 1294143011859 dimer interface [polypeptide binding]; other site 1294143011860 multimer interface [polypeptide binding]; other site 1294143011861 methionine aminotransferase; Validated; Region: PRK09082 1294143011862 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143011863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143011864 homodimer interface [polypeptide binding]; other site 1294143011865 catalytic residue [active] 1294143011866 GTP-binding protein Der; Reviewed; Region: PRK00093 1294143011867 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1294143011868 G1 box; other site 1294143011869 GTP/Mg2+ binding site [chemical binding]; other site 1294143011870 Switch I region; other site 1294143011871 G2 box; other site 1294143011872 Switch II region; other site 1294143011873 G3 box; other site 1294143011874 G4 box; other site 1294143011875 G5 box; other site 1294143011876 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1294143011877 G1 box; other site 1294143011878 GTP/Mg2+ binding site [chemical binding]; other site 1294143011879 Switch I region; other site 1294143011880 G2 box; other site 1294143011881 G3 box; other site 1294143011882 Switch II region; other site 1294143011883 G4 box; other site 1294143011884 G5 box; other site 1294143011885 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1294143011886 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1294143011887 Trp docking motif [polypeptide binding]; other site 1294143011888 active site 1294143011889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1294143011890 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1294143011891 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1294143011892 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1294143011893 dimer interface [polypeptide binding]; other site 1294143011894 motif 1; other site 1294143011895 active site 1294143011896 motif 2; other site 1294143011897 motif 3; other site 1294143011898 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1294143011899 anticodon binding site; other site 1294143011900 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1294143011901 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1294143011902 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1294143011903 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1294143011904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143011905 non-specific DNA binding site [nucleotide binding]; other site 1294143011906 salt bridge; other site 1294143011907 sequence-specific DNA binding site [nucleotide binding]; other site 1294143011908 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1294143011909 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1294143011910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143011911 binding surface 1294143011912 TPR motif; other site 1294143011913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143011914 binding surface 1294143011915 TPR motif; other site 1294143011916 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1294143011917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143011918 FeS/SAM binding site; other site 1294143011919 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1294143011920 active site 1294143011921 multimer interface [polypeptide binding]; other site 1294143011922 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 1294143011923 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1294143011924 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143011925 catalytic loop [active] 1294143011926 iron binding site [ion binding]; other site 1294143011927 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1294143011928 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1294143011929 nucleotide binding site [chemical binding]; other site 1294143011930 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1294143011931 SBD interface [polypeptide binding]; other site 1294143011932 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1294143011933 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1294143011934 HSP70 interaction site [polypeptide binding]; other site 1294143011935 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1294143011936 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 1294143011937 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1294143011938 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1294143011939 trimerization site [polypeptide binding]; other site 1294143011940 active site 1294143011941 cysteine desulfurase; Provisional; Region: PRK14012 1294143011942 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1294143011943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1294143011944 catalytic residue [active] 1294143011945 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1294143011946 Rrf2 family protein; Region: rrf2_super; TIGR00738 1294143011947 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1294143011948 serine O-acetyltransferase; Region: cysE; TIGR01172 1294143011949 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1294143011950 trimer interface [polypeptide binding]; other site 1294143011951 active site 1294143011952 substrate binding site [chemical binding]; other site 1294143011953 CoA binding site [chemical binding]; other site 1294143011954 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1294143011955 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1294143011956 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1294143011957 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1294143011958 active site 1294143011959 dimerization interface [polypeptide binding]; other site 1294143011960 hypothetical protein; Provisional; Region: PRK11280 1294143011961 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1294143011962 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1294143011963 Protein export membrane protein; Region: SecD_SecF; pfam02355 1294143011964 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1294143011965 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1294143011966 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1294143011967 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1294143011968 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1294143011969 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1294143011970 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1294143011971 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1294143011972 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1294143011973 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1294143011974 Type II transport protein GspH; Region: GspH; pfam12019 1294143011975 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1294143011976 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1294143011977 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1294143011978 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1294143011979 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1294143011980 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1294143011981 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1294143011982 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143011983 RDD family; Region: RDD; pfam06271 1294143011984 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1294143011985 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1294143011986 Predicted permeases [General function prediction only]; Region: COG0795 1294143011987 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1294143011988 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1294143011989 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1294143011990 interface (dimer of trimers) [polypeptide binding]; other site 1294143011991 Substrate-binding/catalytic site; other site 1294143011992 Zn-binding sites [ion binding]; other site 1294143011993 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1294143011994 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1294143011995 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1294143011996 HIGH motif; other site 1294143011997 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1294143011998 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1294143011999 active site 1294143012000 KMSKS motif; other site 1294143012001 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1294143012002 tRNA binding surface [nucleotide binding]; other site 1294143012003 anticodon binding site; other site 1294143012004 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1294143012005 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 1294143012006 putative active site [active] 1294143012007 Zn binding site [ion binding]; other site 1294143012008 thiamine pyrophosphate protein; Validated; Region: PRK08199 1294143012009 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1294143012010 PYR/PP interface [polypeptide binding]; other site 1294143012011 dimer interface [polypeptide binding]; other site 1294143012012 TPP binding site [chemical binding]; other site 1294143012013 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853 1294143012014 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1294143012015 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1294143012016 TPP-binding site [chemical binding]; other site 1294143012017 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1294143012018 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1294143012019 TrkA-C domain; Region: TrkA_C; pfam02080 1294143012020 TrkA-C domain; Region: TrkA_C; pfam02080 1294143012021 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1294143012022 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 1294143012023 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1294143012024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143012025 S-adenosylmethionine binding site [chemical binding]; other site 1294143012026 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1294143012027 Isochorismatase family; Region: Isochorismatase; pfam00857 1294143012028 catalytic triad [active] 1294143012029 dimer interface [polypeptide binding]; other site 1294143012030 conserved cis-peptide bond; other site 1294143012031 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1294143012032 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1294143012033 trimer interface [polypeptide binding]; other site 1294143012034 putative metal binding site [ion binding]; other site 1294143012035 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1294143012036 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1294143012037 active site 1294143012038 Zn binding site [ion binding]; other site 1294143012039 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1294143012040 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1294143012041 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1294143012042 dimerization interface [polypeptide binding]; other site 1294143012043 DPS ferroxidase diiron center [ion binding]; other site 1294143012044 ion pore; other site 1294143012045 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1294143012046 Coenzyme A binding pocket [chemical binding]; other site 1294143012047 AAA domain; Region: AAA_23; pfam13476 1294143012048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143012049 Walker A/P-loop; other site 1294143012050 ATP binding site [chemical binding]; other site 1294143012051 Q-loop/lid; other site 1294143012052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143012053 ABC transporter signature motif; other site 1294143012054 Walker B; other site 1294143012055 D-loop; other site 1294143012056 H-loop/switch region; other site 1294143012057 exonuclease subunit SbcD; Provisional; Region: PRK10966 1294143012058 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1294143012059 active site 1294143012060 metal binding site [ion binding]; metal-binding site 1294143012061 DNA binding site [nucleotide binding] 1294143012062 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1294143012063 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1294143012064 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1294143012065 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1294143012066 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1294143012067 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 1294143012068 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143012069 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1294143012070 C-terminal domain interface [polypeptide binding]; other site 1294143012071 GSH binding site (G-site) [chemical binding]; other site 1294143012072 dimer interface [polypeptide binding]; other site 1294143012073 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1294143012074 N-terminal domain interface [polypeptide binding]; other site 1294143012075 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1294143012076 GIY-YIG motif/motif A; other site 1294143012077 putative active site [active] 1294143012078 putative metal binding site [ion binding]; other site 1294143012079 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 1294143012080 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1294143012081 putative C-terminal domain interface [polypeptide binding]; other site 1294143012082 putative GSH binding site [chemical binding]; other site 1294143012083 putative dimer interface [polypeptide binding]; other site 1294143012084 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1294143012085 putative N-terminal domain interface [polypeptide binding]; other site 1294143012086 SnoaL-like domain; Region: SnoaL_2; pfam12680 1294143012087 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143012088 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1294143012089 conserved cys residue [active] 1294143012090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012092 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1294143012093 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1294143012094 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143012095 Walker A/P-loop; other site 1294143012096 ATP binding site [chemical binding]; other site 1294143012097 Q-loop/lid; other site 1294143012098 ABC transporter signature motif; other site 1294143012099 Walker B; other site 1294143012100 D-loop; other site 1294143012101 H-loop/switch region; other site 1294143012102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143012103 dimer interface [polypeptide binding]; other site 1294143012104 conserved gate region; other site 1294143012105 putative PBP binding loops; other site 1294143012106 ABC-ATPase subunit interface; other site 1294143012107 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1294143012108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143012109 conserved gate region; other site 1294143012110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143012111 putative PBP binding loops; other site 1294143012112 dimer interface [polypeptide binding]; other site 1294143012113 ABC-ATPase subunit interface; other site 1294143012114 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1294143012115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143012116 substrate binding pocket [chemical binding]; other site 1294143012117 membrane-bound complex binding site; other site 1294143012118 hinge residues; other site 1294143012119 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1294143012120 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1294143012121 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 1294143012122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143012123 FeS/SAM binding site; other site 1294143012124 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1294143012125 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1294143012126 active site 1294143012127 SAM binding site [chemical binding]; other site 1294143012128 homodimer interface [polypeptide binding]; other site 1294143012129 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143012130 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143012131 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143012132 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143012133 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1294143012134 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1294143012135 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1294143012136 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1294143012137 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1294143012138 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1294143012139 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143012140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143012141 DNA-binding site [nucleotide binding]; DNA binding site 1294143012142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143012143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143012144 homodimer interface [polypeptide binding]; other site 1294143012145 catalytic residue [active] 1294143012146 AMP-binding domain protein; Validated; Region: PRK07529 1294143012147 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143012148 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1294143012149 acyl-activating enzyme (AAE) consensus motif; other site 1294143012150 putative AMP binding site [chemical binding]; other site 1294143012151 putative active site [active] 1294143012152 putative CoA binding site [chemical binding]; other site 1294143012153 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1294143012154 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143012155 ligand binding site [chemical binding]; other site 1294143012156 flexible hinge region; other site 1294143012157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143012158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143012159 metal binding site [ion binding]; metal-binding site 1294143012160 active site 1294143012161 I-site; other site 1294143012162 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1294143012163 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1294143012164 active site 1294143012165 dimer interface [polypeptide binding]; other site 1294143012166 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1294143012167 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1294143012168 ATP binding site [chemical binding]; other site 1294143012169 Mg++ binding site [ion binding]; other site 1294143012170 motif III; other site 1294143012171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143012172 nucleotide binding region [chemical binding]; other site 1294143012173 ATP-binding site [chemical binding]; other site 1294143012174 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1294143012175 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143012176 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1294143012177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1294143012178 YheO-like PAS domain; Region: PAS_6; pfam08348 1294143012179 HTH domain; Region: HTH_22; pfam13309 1294143012180 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1294143012181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143012182 substrate binding pocket [chemical binding]; other site 1294143012183 membrane-bound complex binding site; other site 1294143012184 hinge residues; other site 1294143012185 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1294143012186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143012187 FeS/SAM binding site; other site 1294143012188 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1294143012189 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1294143012190 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1294143012191 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1294143012192 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1294143012193 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1294143012194 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1294143012195 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1294143012196 [4Fe-4S] binding site [ion binding]; other site 1294143012197 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143012198 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143012199 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143012200 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1294143012201 molybdopterin cofactor binding site; other site 1294143012202 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1294143012203 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1294143012204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143012205 putative substrate translocation pore; other site 1294143012206 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1294143012207 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1294143012208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143012209 dimerization interface [polypeptide binding]; other site 1294143012210 Histidine kinase; Region: HisKA_3; pfam07730 1294143012211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143012212 ATP binding site [chemical binding]; other site 1294143012213 Mg2+ binding site [ion binding]; other site 1294143012214 G-X-G motif; other site 1294143012215 transcriptional regulator NarL; Provisional; Region: PRK10651 1294143012216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143012217 active site 1294143012218 phosphorylation site [posttranslational modification] 1294143012219 intermolecular recognition site; other site 1294143012220 dimerization interface [polypeptide binding]; other site 1294143012221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143012222 DNA binding residues [nucleotide binding] 1294143012223 dimerization interface [polypeptide binding]; other site 1294143012224 DGC domain; Region: DGC; pfam08859 1294143012225 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1294143012226 putative protease; Provisional; Region: PRK15447 1294143012227 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1294143012228 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1294143012229 Peptidase family U32; Region: Peptidase_U32; pfam01136 1294143012230 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1294143012231 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1294143012232 dimer interface [polypeptide binding]; other site 1294143012233 putative functional site; other site 1294143012234 putative MPT binding site; other site 1294143012235 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1294143012236 MPT binding site; other site 1294143012237 trimer interface [polypeptide binding]; other site 1294143012238 Peptidase family C69; Region: Peptidase_C69; cl17793 1294143012239 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1294143012240 MoaE homodimer interface [polypeptide binding]; other site 1294143012241 MoaD interaction [polypeptide binding]; other site 1294143012242 active site residues [active] 1294143012243 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1294143012244 MoaE interaction surface [polypeptide binding]; other site 1294143012245 MoeB interaction surface [polypeptide binding]; other site 1294143012246 thiocarboxylated glycine; other site 1294143012247 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1294143012248 trimer interface [polypeptide binding]; other site 1294143012249 dimer interface [polypeptide binding]; other site 1294143012250 putative active site [active] 1294143012251 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1294143012252 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1294143012253 putative active site [active] 1294143012254 PhoH-like protein; Region: PhoH; pfam02562 1294143012255 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1294143012256 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1294143012257 active site 1294143012258 Zn binding site [ion binding]; other site 1294143012259 allantoate amidohydrolase; Reviewed; Region: PRK12893 1294143012260 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1294143012261 active site 1294143012262 metal binding site [ion binding]; metal-binding site 1294143012263 dimer interface [polypeptide binding]; other site 1294143012264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143012265 metabolite-proton symporter; Region: 2A0106; TIGR00883 1294143012266 putative substrate translocation pore; other site 1294143012267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143012268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143012269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143012270 dimerization interface [polypeptide binding]; other site 1294143012271 hypothetical protein; Validated; Region: PRK02101 1294143012272 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1294143012273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143012274 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1294143012275 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1294143012276 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1294143012277 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1294143012278 PilZ domain; Region: PilZ; pfam07238 1294143012279 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1294143012280 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1294143012281 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143012282 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1294143012283 Right handed beta helix region; Region: Beta_helix; pfam13229 1294143012284 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1294143012285 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1294143012286 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1294143012287 active site 1294143012288 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1294143012289 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1294143012290 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1294143012291 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1294143012292 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1294143012293 Substrate binding site; other site 1294143012294 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1294143012295 short chain dehydrogenase; Provisional; Region: PRK05693 1294143012296 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1294143012297 NADP binding site [chemical binding]; other site 1294143012298 active site 1294143012299 steroid binding site; other site 1294143012300 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1294143012301 active site 1294143012302 catalytic residues [active] 1294143012303 HlyD family secretion protein; Region: HlyD; pfam00529 1294143012304 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143012305 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143012306 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1294143012307 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1294143012308 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1294143012309 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1294143012310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143012311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143012312 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143012313 putative effector binding pocket; other site 1294143012314 dimerization interface [polypeptide binding]; other site 1294143012315 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1294143012316 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1294143012317 dimerization interface [polypeptide binding]; other site 1294143012318 ligand binding site [chemical binding]; other site 1294143012319 NADP binding site [chemical binding]; other site 1294143012320 catalytic site [active] 1294143012321 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1294143012322 Chain length determinant protein; Region: Wzz; pfam02706 1294143012323 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1294143012324 EamA-like transporter family; Region: EamA; pfam00892 1294143012325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012326 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143012327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012328 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1294143012329 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1294143012330 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1294143012331 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1294143012332 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143012333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143012334 DNA-binding site [nucleotide binding]; DNA binding site 1294143012335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143012336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143012337 homodimer interface [polypeptide binding]; other site 1294143012338 catalytic residue [active] 1294143012339 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1294143012340 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1294143012341 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143012342 ATP binding site [chemical binding]; other site 1294143012343 putative Mg++ binding site [ion binding]; other site 1294143012344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143012345 nucleotide binding region [chemical binding]; other site 1294143012346 ATP-binding site [chemical binding]; other site 1294143012347 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 1294143012348 classical (c) SDRs; Region: SDR_c; cd05233 1294143012349 NAD(P) binding site [chemical binding]; other site 1294143012350 active site 1294143012351 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1294143012352 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143012353 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1294143012354 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1294143012355 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1294143012356 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1294143012357 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143012358 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143012359 Predicted membrane protein [Function unknown]; Region: COG3223 1294143012360 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1294143012361 YebG protein; Region: YebG; pfam07130 1294143012362 Seed dormancy control; Region: DOG1; pfam14144 1294143012363 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1294143012364 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143012365 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1294143012366 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1294143012367 homotrimer interaction site [polypeptide binding]; other site 1294143012368 putative active site [active] 1294143012369 EthD domain; Region: EthD; cl17553 1294143012370 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1294143012371 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1294143012372 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1294143012373 Cytochrome c; Region: Cytochrom_C; cl11414 1294143012374 Cytochrome c; Region: Cytochrom_C; cl11414 1294143012375 Cytochrome c; Region: Cytochrom_C; cl11414 1294143012376 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1294143012377 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143012378 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143012379 lipid-transfer protein; Provisional; Region: PRK08256 1294143012380 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1294143012381 active site 1294143012382 acyl-CoA synthetase; Validated; Region: PRK06188 1294143012383 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1294143012384 putative active site [active] 1294143012385 putative CoA binding site [chemical binding]; other site 1294143012386 putative AMP binding site [chemical binding]; other site 1294143012387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143012388 NAD(P) binding site [chemical binding]; other site 1294143012389 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143012390 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1294143012391 active site 1294143012392 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1294143012393 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143012394 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143012395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012396 beta-ketothiolase; Provisional; Region: PRK09051 1294143012397 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143012398 dimer interface [polypeptide binding]; other site 1294143012399 active site 1294143012400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143012401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143012402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143012403 PAS fold; Region: PAS_3; pfam08447 1294143012404 putative active site [active] 1294143012405 heme pocket [chemical binding]; other site 1294143012406 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143012407 putative CheW interface [polypeptide binding]; other site 1294143012408 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1294143012409 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1294143012410 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1294143012411 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143012412 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143012413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143012414 Phosphotransferase enzyme family; Region: APH; pfam01636 1294143012415 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1294143012416 putative active site [active] 1294143012417 putative substrate binding site [chemical binding]; other site 1294143012418 ATP binding site [chemical binding]; other site 1294143012419 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1294143012420 classical (c) SDRs; Region: SDR_c; cd05233 1294143012421 NAD(P) binding site [chemical binding]; other site 1294143012422 active site 1294143012423 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143012424 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1294143012425 substrate binding site [chemical binding]; other site 1294143012426 oxyanion hole (OAH) forming residues; other site 1294143012427 trimer interface [polypeptide binding]; other site 1294143012428 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143012429 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143012430 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143012431 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143012432 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143012433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012434 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143012435 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143012436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143012438 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1294143012439 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1294143012440 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143012441 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143012442 active site 1294143012443 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143012444 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1294143012445 active site 1294143012446 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1294143012447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143012448 motif II; other site 1294143012449 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1294143012450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143012451 sequence-specific DNA binding site [nucleotide binding]; other site 1294143012452 salt bridge; other site 1294143012453 YebG protein; Region: YebG; cl01217 1294143012454 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1294143012455 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1294143012456 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1294143012457 NAD binding site [chemical binding]; other site 1294143012458 Phe binding site; other site 1294143012459 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1294143012460 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1294143012461 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1294143012462 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1294143012463 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143012464 dimerization interface [polypeptide binding]; other site 1294143012465 DNA binding residues [nucleotide binding] 1294143012466 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143012467 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143012468 SnoaL-like domain; Region: SnoaL_2; pfam12680 1294143012469 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143012470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012471 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143012472 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143012473 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1294143012474 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1294143012475 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143012476 substrate binding site [chemical binding]; other site 1294143012477 oxyanion hole (OAH) forming residues; other site 1294143012478 trimer interface [polypeptide binding]; other site 1294143012479 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1294143012480 homodimer interface [polypeptide binding]; other site 1294143012481 NAD binding site [chemical binding]; other site 1294143012482 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1294143012483 active site 1294143012484 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143012485 aldolase II superfamily protein; Provisional; Region: PRK07044 1294143012486 intersubunit interface [polypeptide binding]; other site 1294143012487 active site 1294143012488 Zn2+ binding site [ion binding]; other site 1294143012489 WbqC-like protein family; Region: WbqC; pfam08889 1294143012490 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1294143012491 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1294143012492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143012493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143012494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143012495 dimerization interface [polypeptide binding]; other site 1294143012496 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1294143012497 flavodoxin; Provisional; Region: PRK05723 1294143012498 dihydromonapterin reductase; Provisional; Region: PRK06483 1294143012499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143012500 NAD(P) binding site [chemical binding]; other site 1294143012501 active site 1294143012502 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1294143012503 GTP cyclohydrolase I; Provisional; Region: PLN03044 1294143012504 homodecamer interface [polypeptide binding]; other site 1294143012505 active site 1294143012506 putative catalytic site residues [active] 1294143012507 zinc binding site [ion binding]; other site 1294143012508 GTP-CH-I/GFRP interaction surface; other site 1294143012509 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 1294143012510 active site 1294143012511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1294143012512 HopJ type III effector protein; Region: HopJ; pfam08888 1294143012513 thioredoxin reductase; Provisional; Region: PRK10262 1294143012514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143012515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143012516 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 1294143012517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143012518 dimerization interface [polypeptide binding]; other site 1294143012519 PAS domain S-box; Region: sensory_box; TIGR00229 1294143012520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143012521 putative active site [active] 1294143012522 heme pocket [chemical binding]; other site 1294143012523 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143012524 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143012525 metal binding site [ion binding]; metal-binding site 1294143012526 active site 1294143012527 I-site; other site 1294143012528 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1294143012529 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143012530 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1294143012531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1294143012532 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1294143012533 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1294143012534 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1294143012535 putative active site [active] 1294143012536 putative FMN binding site [chemical binding]; other site 1294143012537 putative substrate binding site [chemical binding]; other site 1294143012538 putative catalytic residue [active] 1294143012539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143012540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143012541 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1294143012542 dimer interface [polypeptide binding]; other site 1294143012543 FMN binding site [chemical binding]; other site 1294143012544 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1294143012545 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1294143012546 catalytic residues [active] 1294143012547 dimer interface [polypeptide binding]; other site 1294143012548 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1294143012549 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1294143012550 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 1294143012551 propionate/acetate kinase; Provisional; Region: PRK12379 1294143012552 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1294143012553 nucleotide binding site [chemical binding]; other site 1294143012554 Butyrate kinase [Energy production and conversion]; Region: COG3426 1294143012555 phosphate acetyltransferase; Reviewed; Region: PRK05632 1294143012556 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1294143012557 DRTGG domain; Region: DRTGG; pfam07085 1294143012558 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1294143012559 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1294143012560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1294143012561 putative acyl-acceptor binding pocket; other site 1294143012562 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143012563 ligand binding site [chemical binding]; other site 1294143012564 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1294143012565 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143012566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143012567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012568 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1294143012569 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1294143012570 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1294143012571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143012572 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1294143012573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143012574 DNA binding residues [nucleotide binding] 1294143012575 dimerization interface [polypeptide binding]; other site 1294143012576 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1294143012577 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1294143012578 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1294143012579 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1294143012580 dimer interface [polypeptide binding]; other site 1294143012581 acyl-activating enzyme (AAE) consensus motif; other site 1294143012582 putative active site [active] 1294143012583 AMP binding site [chemical binding]; other site 1294143012584 putative CoA binding site [chemical binding]; other site 1294143012585 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1294143012586 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143012587 dimer interface [polypeptide binding]; other site 1294143012588 active site 1294143012589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143012590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143012591 putative substrate translocation pore; other site 1294143012592 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143012593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143012595 LysE type translocator; Region: LysE; cl00565 1294143012596 glycerate dehydrogenase; Provisional; Region: PRK06487 1294143012597 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1294143012598 putative ligand binding site [chemical binding]; other site 1294143012599 putative NAD binding site [chemical binding]; other site 1294143012600 catalytic site [active] 1294143012601 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1294143012602 Protein of unknown function; Region: DUF3658; pfam12395 1294143012603 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1294143012604 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1294143012605 Methyltransferase small domain; Region: MTS; pfam05175 1294143012606 lysine transporter; Provisional; Region: PRK10836 1294143012607 Predicted membrane protein [Function unknown]; Region: COG2119 1294143012608 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1294143012609 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1294143012610 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1294143012611 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1294143012612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143012613 NAD(P) binding site [chemical binding]; other site 1294143012614 active site 1294143012615 Peptidase family M48; Region: Peptidase_M48; pfam01435 1294143012616 Cache domain; Region: Cache_1; pfam02743 1294143012617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143012618 dimerization interface [polypeptide binding]; other site 1294143012619 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143012620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143012621 dimer interface [polypeptide binding]; other site 1294143012622 putative CheW interface [polypeptide binding]; other site 1294143012623 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1294143012624 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1294143012625 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1294143012626 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1294143012627 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1294143012628 putative acyl-acceptor binding pocket; other site 1294143012629 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1294143012630 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1294143012631 malate:quinone oxidoreductase; Validated; Region: PRK05257 1294143012632 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1294143012633 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1294143012634 dimer interface [polypeptide binding]; other site 1294143012635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1294143012636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143012637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143012638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143012639 dimerization interface [polypeptide binding]; other site 1294143012640 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1294143012641 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1294143012642 NAD(P) binding site [chemical binding]; other site 1294143012643 catalytic residues [active] 1294143012644 catalytic residues [active] 1294143012645 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1294143012646 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143012647 active site 1294143012648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143012649 active site 1294143012650 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1294143012651 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1294143012652 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1294143012653 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1294143012654 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1294143012655 putative active site [active] 1294143012656 putative substrate binding site [chemical binding]; other site 1294143012657 putative cosubstrate binding site; other site 1294143012658 catalytic site [active] 1294143012659 exonuclease I; Provisional; Region: sbcB; PRK11779 1294143012660 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1294143012661 active site 1294143012662 catalytic site [active] 1294143012663 substrate binding site [chemical binding]; other site 1294143012664 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1294143012665 RDD family; Region: RDD; pfam06271 1294143012666 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1294143012667 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1294143012668 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1294143012669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143012670 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1294143012671 Walker A motif; other site 1294143012672 ATP binding site [chemical binding]; other site 1294143012673 Walker B motif; other site 1294143012674 arginine finger; other site 1294143012675 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1294143012676 Protein of unknown function DUF58; Region: DUF58; pfam01882 1294143012677 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1294143012678 metal ion-dependent adhesion site (MIDAS); other site 1294143012679 PilZ domain; Region: PilZ; pfam07238 1294143012680 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1294143012681 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1294143012682 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1294143012683 universal stress protein UspE; Provisional; Region: PRK11175 1294143012684 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143012685 Ligand Binding Site [chemical binding]; other site 1294143012686 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143012687 Ligand Binding Site [chemical binding]; other site 1294143012688 pyruvate kinase; Provisional; Region: PRK05826 1294143012689 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1294143012690 domain interfaces; other site 1294143012691 active site 1294143012692 enoyl-CoA hydratase; Provisional; Region: PRK06688 1294143012693 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143012694 substrate binding site [chemical binding]; other site 1294143012695 oxyanion hole (OAH) forming residues; other site 1294143012696 trimer interface [polypeptide binding]; other site 1294143012697 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1294143012698 hypothetical protein; Provisional; Region: PRK05713 1294143012699 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143012700 catalytic loop [active] 1294143012701 iron binding site [ion binding]; other site 1294143012702 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1294143012703 FAD binding pocket [chemical binding]; other site 1294143012704 FAD binding motif [chemical binding]; other site 1294143012705 phosphate binding motif [ion binding]; other site 1294143012706 beta-alpha-beta structure motif; other site 1294143012707 NAD binding pocket [chemical binding]; other site 1294143012708 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143012709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143012710 metal binding site [ion binding]; metal-binding site 1294143012711 active site 1294143012712 I-site; other site 1294143012713 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1294143012714 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1294143012715 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1294143012716 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1294143012717 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1294143012718 conserved cys residue [active] 1294143012719 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1294143012720 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1294143012721 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1294143012722 PLD-like domain; Region: PLDc_2; pfam13091 1294143012723 putative active site [active] 1294143012724 catalytic site [active] 1294143012725 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1294143012726 PLD-like domain; Region: PLDc_2; pfam13091 1294143012727 putative active site [active] 1294143012728 catalytic site [active] 1294143012729 YceI-like domain; Region: YceI; pfam04264 1294143012730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143012731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143012732 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1294143012733 putative effector binding pocket; other site 1294143012734 putative dimerization interface [polypeptide binding]; other site 1294143012735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143012736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143012737 putative substrate translocation pore; other site 1294143012738 YceI-like domain; Region: YceI; pfam04264 1294143012739 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1294143012740 Beta-lactamase; Region: Beta-lactamase; pfam00144 1294143012741 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1294143012742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1294143012743 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1294143012744 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1294143012745 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1294143012746 putative acyl-acceptor binding pocket; other site 1294143012747 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143012748 Ligand Binding Site [chemical binding]; other site 1294143012749 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143012750 Ligand Binding Site [chemical binding]; other site 1294143012751 Protein of unknown function, DUF479; Region: DUF479; cl01203 1294143012752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143012753 dimerization interface [polypeptide binding]; other site 1294143012754 putative DNA binding site [nucleotide binding]; other site 1294143012755 putative Zn2+ binding site [ion binding]; other site 1294143012756 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1294143012757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143012758 putative substrate translocation pore; other site 1294143012759 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1294143012760 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1294143012761 FMN binding site [chemical binding]; other site 1294143012762 active site 1294143012763 substrate binding site [chemical binding]; other site 1294143012764 catalytic residue [active] 1294143012765 FeoC like transcriptional regulator; Region: FeoC; cl17677 1294143012766 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1294143012767 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1294143012768 G1 box; other site 1294143012769 GTP/Mg2+ binding site [chemical binding]; other site 1294143012770 Switch I region; other site 1294143012771 G2 box; other site 1294143012772 G3 box; other site 1294143012773 Switch II region; other site 1294143012774 G4 box; other site 1294143012775 G5 box; other site 1294143012776 Nucleoside recognition; Region: Gate; pfam07670 1294143012777 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1294143012778 Nucleoside recognition; Region: Gate; pfam07670 1294143012779 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1294143012780 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1294143012781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1294143012782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143012783 NAD(P) binding site [chemical binding]; other site 1294143012784 active site 1294143012785 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1294143012786 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1294143012787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143012788 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143012789 dimerization interface [polypeptide binding]; other site 1294143012790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1294143012791 ACT domain; Region: ACT_3; pfam10000 1294143012792 LysE type translocator; Region: LysE; cl00565 1294143012793 superoxide dismutase; Provisional; Region: PRK10543 1294143012794 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1294143012795 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1294143012796 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1294143012797 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143012798 metal binding site [ion binding]; metal-binding site 1294143012799 active site 1294143012800 I-site; other site 1294143012801 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143012802 Imelysin; Region: Peptidase_M75; cl09159 1294143012803 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1294143012804 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1294143012805 Imelysin; Region: Peptidase_M75; cl09159 1294143012806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 1294143012807 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1294143012808 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143012809 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143012810 multidrug efflux protein; Reviewed; Region: PRK09579 1294143012811 Protein export membrane protein; Region: SecD_SecF; cl14618 1294143012812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143012813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143012814 putative substrate translocation pore; other site 1294143012815 ferrochelatase; Reviewed; Region: hemH; PRK00035 1294143012816 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1294143012817 C-terminal domain interface [polypeptide binding]; other site 1294143012818 active site 1294143012819 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1294143012820 active site 1294143012821 N-terminal domain interface [polypeptide binding]; other site 1294143012822 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1294143012823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143012824 NAD(P) binding site [chemical binding]; other site 1294143012825 active site 1294143012826 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1294143012827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143012828 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1294143012829 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1294143012830 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1294143012831 DNA binding residues [nucleotide binding] 1294143012832 transcriptional regulator MirA; Provisional; Region: PRK15043 1294143012833 B12 binding domain; Region: B12-binding_2; pfam02607 1294143012834 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1294143012835 DNA photolyase; Region: DNA_photolyase; pfam00875 1294143012836 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cl07841 1294143012837 active site 1294143012838 Transposase domain (DUF772); Region: DUF772; pfam05598 1294143012839 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1294143012840 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1294143012841 glutamate racemase; Provisional; Region: PRK00865 1294143012842 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1294143012843 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1294143012844 ATP binding site [chemical binding]; other site 1294143012845 substrate interface [chemical binding]; other site 1294143012846 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1294143012847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143012848 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1294143012849 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1294143012850 RF-1 domain; Region: RF-1; pfam00472 1294143012851 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1294143012852 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1294143012853 tRNA; other site 1294143012854 putative tRNA binding site [nucleotide binding]; other site 1294143012855 putative NADP binding site [chemical binding]; other site 1294143012856 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1294143012857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143012858 binding surface 1294143012859 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1294143012860 TPR motif; other site 1294143012861 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1294143012862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1294143012863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143012864 binding surface 1294143012865 TPR motif; other site 1294143012866 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1294143012867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1294143012868 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1294143012869 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1294143012870 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1294143012871 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1294143012872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143012873 active site 1294143012874 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1294143012875 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1294143012876 5S rRNA interface [nucleotide binding]; other site 1294143012877 CTC domain interface [polypeptide binding]; other site 1294143012878 L16 interface [polypeptide binding]; other site 1294143012879 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1294143012880 putative active site [active] 1294143012881 GTP-binding protein YchF; Reviewed; Region: PRK09601 1294143012882 YchF GTPase; Region: YchF; cd01900 1294143012883 G1 box; other site 1294143012884 GTP/Mg2+ binding site [chemical binding]; other site 1294143012885 Switch I region; other site 1294143012886 G2 box; other site 1294143012887 Switch II region; other site 1294143012888 G3 box; other site 1294143012889 G4 box; other site 1294143012890 G5 box; other site 1294143012891 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1294143012892 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1294143012893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143012894 non-specific DNA binding site [nucleotide binding]; other site 1294143012895 salt bridge; other site 1294143012896 sequence-specific DNA binding site [nucleotide binding]; other site 1294143012897 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1294143012898 integrase; Provisional; Region: int; PHA02601 1294143012899 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143012900 active site 1294143012901 DNA binding site [nucleotide binding] 1294143012902 Int/Topo IB signature motif; other site 1294143012903 Replication initiation factor; Region: Rep_trans; pfam02486 1294143012904 Zonular occludens toxin (Zot); Region: Zot; cl17485 1294143012905 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 1294143012906 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 1294143012907 Restriction endonuclease; Region: Mrr_cat; pfam04471 1294143012908 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1294143012909 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1294143012910 oligomeric interface; other site 1294143012911 putative active site [active] 1294143012912 homodimer interface [polypeptide binding]; other site 1294143012913 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1294143012914 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1294143012915 tartrate dehydrogenase; Region: TTC; TIGR02089 1294143012916 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1294143012917 active site clefts [active] 1294143012918 zinc binding site [ion binding]; other site 1294143012919 dimer interface [polypeptide binding]; other site 1294143012920 Peptidase family C69; Region: Peptidase_C69; cl17793 1294143012921 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1294143012922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143012923 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1294143012924 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1294143012925 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1294143012926 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1294143012927 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1294143012928 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1294143012929 mce related protein; Region: MCE; pfam02470 1294143012930 mce related protein; Region: MCE; pfam02470 1294143012931 mce related protein; Region: MCE; pfam02470 1294143012932 mce related protein; Region: MCE; pfam02470 1294143012933 mce related protein; Region: MCE; pfam02470 1294143012934 mce related protein; Region: MCE; pfam02470 1294143012935 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1294143012936 Paraquat-inducible protein A; Region: PqiA; pfam04403 1294143012937 Paraquat-inducible protein A; Region: PqiA; pfam04403 1294143012938 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1294143012939 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1294143012940 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1294143012941 Moco binding site; other site 1294143012942 metal coordination site [ion binding]; other site 1294143012943 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1294143012944 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1294143012945 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1294143012946 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1294143012947 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1294143012948 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1294143012949 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1294143012950 putative valine binding site [chemical binding]; other site 1294143012951 dimer interface [polypeptide binding]; other site 1294143012952 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1294143012953 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1294143012954 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1294143012955 PYR/PP interface [polypeptide binding]; other site 1294143012956 dimer interface [polypeptide binding]; other site 1294143012957 TPP binding site [chemical binding]; other site 1294143012958 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1294143012959 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1294143012960 TPP-binding site [chemical binding]; other site 1294143012961 dimer interface [polypeptide binding]; other site 1294143012962 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1294143012963 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1294143012964 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1294143012965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1294143012966 TPR motif; other site 1294143012967 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1294143012968 Transglycosylase; Region: Transgly; pfam00912 1294143012969 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1294143012970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1294143012971 Predicted kinase [General function prediction only]; Region: COG0645 1294143012972 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1294143012973 active site 1294143012974 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1294143012975 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143012976 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1294143012977 ligand binding site [chemical binding]; other site 1294143012978 flexible hinge region; other site 1294143012979 Protein of unknown function, DUF399; Region: DUF399; cl01139 1294143012980 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1294143012981 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1294143012982 Walker A/P-loop; other site 1294143012983 ATP binding site [chemical binding]; other site 1294143012984 Q-loop/lid; other site 1294143012985 ABC transporter signature motif; other site 1294143012986 Walker B; other site 1294143012987 D-loop; other site 1294143012988 H-loop/switch region; other site 1294143012989 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1294143012990 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1294143012991 ABC-ATPase subunit interface; other site 1294143012992 dimer interface [polypeptide binding]; other site 1294143012993 putative PBP binding regions; other site 1294143012994 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1294143012995 iron-sulfur cluster [ion binding]; other site 1294143012996 [2Fe-2S] cluster binding site [ion binding]; other site 1294143012997 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1294143012998 hypothetical protein; Provisional; Region: PRK08960 1294143012999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143013000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143013001 homodimer interface [polypeptide binding]; other site 1294143013002 catalytic residue [active] 1294143013003 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1294143013004 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1294143013005 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1294143013006 active site 1294143013007 HIGH motif; other site 1294143013008 nucleotide binding site [chemical binding]; other site 1294143013009 KMSKS motif; other site 1294143013010 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1294143013011 Na binding site [ion binding]; other site 1294143013012 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1294143013013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143013014 putative active site [active] 1294143013015 heme pocket [chemical binding]; other site 1294143013016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143013017 dimer interface [polypeptide binding]; other site 1294143013018 phosphorylation site [posttranslational modification] 1294143013019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143013020 ATP binding site [chemical binding]; other site 1294143013021 Mg2+ binding site [ion binding]; other site 1294143013022 G-X-G motif; other site 1294143013023 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1294143013024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143013025 active site 1294143013026 phosphorylation site [posttranslational modification] 1294143013027 intermolecular recognition site; other site 1294143013028 dimerization interface [polypeptide binding]; other site 1294143013029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143013030 Walker A motif; other site 1294143013031 ATP binding site [chemical binding]; other site 1294143013032 Walker B motif; other site 1294143013033 arginine finger; other site 1294143013034 poly(A) polymerase; Region: pcnB; TIGR01942 1294143013035 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1294143013036 active site 1294143013037 NTP binding site [chemical binding]; other site 1294143013038 metal binding triad [ion binding]; metal-binding site 1294143013039 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1294143013040 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1294143013041 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1294143013042 catalytic center binding site [active] 1294143013043 ATP binding site [chemical binding]; other site 1294143013044 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1294143013045 oligomerization interface [polypeptide binding]; other site 1294143013046 active site 1294143013047 metal binding site [ion binding]; metal-binding site 1294143013048 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1294143013049 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1294143013050 active site 1294143013051 ATP-binding site [chemical binding]; other site 1294143013052 pantoate-binding site; other site 1294143013053 HXXH motif; other site 1294143013054 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1294143013055 tetramerization interface [polypeptide binding]; other site 1294143013056 active site 1294143013057 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1294143013058 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1294143013059 active site 1294143013060 dimer interface [polypeptide binding]; other site 1294143013061 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1294143013062 dimer interface [polypeptide binding]; other site 1294143013063 active site 1294143013064 acetyl-CoA synthetase; Provisional; Region: PRK00174 1294143013065 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1294143013066 active site 1294143013067 CoA binding site [chemical binding]; other site 1294143013068 acyl-activating enzyme (AAE) consensus motif; other site 1294143013069 AMP binding site [chemical binding]; other site 1294143013070 acetate binding site [chemical binding]; other site 1294143013071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1294143013072 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143013073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143013074 active site 1294143013075 phosphorylation site [posttranslational modification] 1294143013076 intermolecular recognition site; other site 1294143013077 dimerization interface [polypeptide binding]; other site 1294143013078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143013079 DNA binding residues [nucleotide binding] 1294143013080 dimerization interface [polypeptide binding]; other site 1294143013081 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1294143013082 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1294143013083 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1294143013084 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1294143013085 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1294143013086 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1294143013087 Rhomboid family; Region: Rhomboid; pfam01694 1294143013088 BON domain; Region: BON; pfam04972 1294143013089 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 1294143013090 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1294143013091 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1294143013092 RNase E interface [polypeptide binding]; other site 1294143013093 trimer interface [polypeptide binding]; other site 1294143013094 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1294143013095 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1294143013096 RNase E interface [polypeptide binding]; other site 1294143013097 trimer interface [polypeptide binding]; other site 1294143013098 active site 1294143013099 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1294143013100 putative nucleic acid binding region [nucleotide binding]; other site 1294143013101 G-X-X-G motif; other site 1294143013102 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1294143013103 RNA binding site [nucleotide binding]; other site 1294143013104 domain interface; other site 1294143013105 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1294143013106 16S/18S rRNA binding site [nucleotide binding]; other site 1294143013107 S13e-L30e interaction site [polypeptide binding]; other site 1294143013108 25S rRNA binding site [nucleotide binding]; other site 1294143013109 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1294143013110 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1294143013111 RNA binding site [nucleotide binding]; other site 1294143013112 active site 1294143013113 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1294143013114 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1294143013115 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1294143013116 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1294143013117 translation initiation factor IF-2; Region: IF-2; TIGR00487 1294143013118 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1294143013119 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1294143013120 G1 box; other site 1294143013121 putative GEF interaction site [polypeptide binding]; other site 1294143013122 GTP/Mg2+ binding site [chemical binding]; other site 1294143013123 Switch I region; other site 1294143013124 G2 box; other site 1294143013125 G3 box; other site 1294143013126 Switch II region; other site 1294143013127 G4 box; other site 1294143013128 G5 box; other site 1294143013129 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1294143013130 Translation-initiation factor 2; Region: IF-2; pfam11987 1294143013131 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1294143013132 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1294143013133 NusA N-terminal domain; Region: NusA_N; pfam08529 1294143013134 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1294143013135 RNA binding site [nucleotide binding]; other site 1294143013136 homodimer interface [polypeptide binding]; other site 1294143013137 NusA-like KH domain; Region: KH_5; pfam13184 1294143013138 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1294143013139 G-X-X-G motif; other site 1294143013140 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1294143013141 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1294143013142 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1294143013143 Sm and related proteins; Region: Sm_like; cl00259 1294143013144 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1294143013145 putative oligomer interface [polypeptide binding]; other site 1294143013146 putative RNA binding site [nucleotide binding]; other site 1294143013147 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1294143013148 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1294143013149 triosephosphate isomerase; Provisional; Region: PRK14567 1294143013150 substrate binding site [chemical binding]; other site 1294143013151 dimer interface [polypeptide binding]; other site 1294143013152 catalytic triad [active] 1294143013153 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1294143013154 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1294143013155 active site 1294143013156 substrate binding site [chemical binding]; other site 1294143013157 metal binding site [ion binding]; metal-binding site 1294143013158 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1294143013159 dihydropteroate synthase; Region: DHPS; TIGR01496 1294143013160 substrate binding pocket [chemical binding]; other site 1294143013161 dimer interface [polypeptide binding]; other site 1294143013162 inhibitor binding site; inhibition site 1294143013163 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1294143013164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143013165 Walker A motif; other site 1294143013166 ATP binding site [chemical binding]; other site 1294143013167 Walker B motif; other site 1294143013168 arginine finger; other site 1294143013169 Peptidase family M41; Region: Peptidase_M41; pfam01434 1294143013170 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1294143013171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143013172 S-adenosylmethionine binding site [chemical binding]; other site 1294143013173 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1294143013174 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 1294143013175 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1294143013176 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1294143013177 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1294143013178 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1294143013179 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1294143013180 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1294143013181 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1294143013182 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1294143013183 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143013184 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1294143013185 IMP binding site; other site 1294143013186 dimer interface [polypeptide binding]; other site 1294143013187 interdomain contacts; other site 1294143013188 partial ornithine binding site; other site 1294143013189 leucine export protein LeuE; Provisional; Region: PRK10958 1294143013190 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1294143013191 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1294143013192 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1294143013193 catalytic site [active] 1294143013194 subunit interface [polypeptide binding]; other site 1294143013195 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1294143013196 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1294143013197 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1294143013198 chaperone protein DnaJ; Provisional; Region: PRK10767 1294143013199 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1294143013200 HSP70 interaction site [polypeptide binding]; other site 1294143013201 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1294143013202 substrate binding site [polypeptide binding]; other site 1294143013203 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1294143013204 Zn binding sites [ion binding]; other site 1294143013205 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1294143013206 dimer interface [polypeptide binding]; other site 1294143013207 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1294143013208 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1294143013209 nucleotide binding site [chemical binding]; other site 1294143013210 NEF interaction site [polypeptide binding]; other site 1294143013211 SBD interface [polypeptide binding]; other site 1294143013212 GrpE; Region: GrpE; pfam01025 1294143013213 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1294143013214 dimer interface [polypeptide binding]; other site 1294143013215 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1294143013216 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1294143013217 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1294143013218 Walker A/P-loop; other site 1294143013219 ATP binding site [chemical binding]; other site 1294143013220 Q-loop/lid; other site 1294143013221 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1294143013222 ABC transporter signature motif; other site 1294143013223 Walker B; other site 1294143013224 D-loop; other site 1294143013225 H-loop/switch region; other site 1294143013226 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1294143013227 metal binding site 2 [ion binding]; metal-binding site 1294143013228 putative DNA binding helix; other site 1294143013229 metal binding site 1 [ion binding]; metal-binding site 1294143013230 dimer interface [polypeptide binding]; other site 1294143013231 structural Zn2+ binding site [ion binding]; other site 1294143013232 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1294143013233 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 1294143013234 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1294143013235 putative coenzyme Q binding site [chemical binding]; other site 1294143013236 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1294143013237 SmpB-tmRNA interface; other site 1294143013238 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1294143013239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143013240 DNA-binding site [nucleotide binding]; DNA binding site 1294143013241 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1294143013242 glycolate transporter; Provisional; Region: PRK09695 1294143013243 L-lactate permease; Region: Lactate_perm; cl00701 1294143013244 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1294143013245 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1294143013246 phosphate binding site [ion binding]; other site 1294143013247 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1294143013248 FAD binding domain; Region: FAD_binding_4; pfam01565 1294143013249 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1294143013250 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1294143013251 Cysteine-rich domain; Region: CCG; pfam02754 1294143013252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143013253 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1294143013254 active site 1294143013255 phosphorylation site [posttranslational modification] 1294143013256 intermolecular recognition site; other site 1294143013257 dimerization interface [polypeptide binding]; other site 1294143013258 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143013259 DNA binding site [nucleotide binding] 1294143013260 sensor protein QseC; Provisional; Region: PRK10337 1294143013261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143013262 dimer interface [polypeptide binding]; other site 1294143013263 phosphorylation site [posttranslational modification] 1294143013264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143013265 ATP binding site [chemical binding]; other site 1294143013266 Mg2+ binding site [ion binding]; other site 1294143013267 G-X-G motif; other site 1294143013268 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1294143013269 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1294143013270 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1294143013271 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1294143013272 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1294143013273 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1294143013274 carboxyltransferase (CT) interaction site; other site 1294143013275 biotinylation site [posttranslational modification]; other site 1294143013276 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1294143013277 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1294143013278 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1294143013279 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1294143013280 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1294143013281 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1294143013282 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1294143013283 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1294143013284 potential catalytic triad [active] 1294143013285 conserved cys residue [active] 1294143013286 Protein of unknown function, DUF480; Region: DUF480; cl01209 1294143013287 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1294143013288 ligand-binding site [chemical binding]; other site 1294143013289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143013290 Walker A/P-loop; other site 1294143013291 ATP binding site [chemical binding]; other site 1294143013292 Q-loop/lid; other site 1294143013293 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143013294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143013295 DNA-binding site [nucleotide binding]; DNA binding site 1294143013296 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1294143013297 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1294143013298 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1294143013299 P-loop, Walker A motif; other site 1294143013300 Base recognition motif; other site 1294143013301 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1294143013302 Uncharacterized small protein [Function unknown]; Region: COG2879 1294143013303 carbon starvation protein A; Provisional; Region: PRK15015 1294143013304 Carbon starvation protein CstA; Region: CstA; pfam02554 1294143013305 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1294143013306 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1294143013307 PilZ domain; Region: PilZ; pfam07238 1294143013308 DNA repair protein RadA; Provisional; Region: PRK11823 1294143013309 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1294143013310 Walker A motif/ATP binding site; other site 1294143013311 ATP binding site [chemical binding]; other site 1294143013312 Walker B motif; other site 1294143013313 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1294143013314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 1294143013315 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1294143013316 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1294143013317 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1294143013318 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1294143013319 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1294143013320 Transporter associated domain; Region: CorC_HlyC; smart01091 1294143013321 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1294143013322 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1294143013323 FAD binding pocket [chemical binding]; other site 1294143013324 FAD binding motif [chemical binding]; other site 1294143013325 phosphate binding motif [ion binding]; other site 1294143013326 beta-alpha-beta structure motif; other site 1294143013327 NAD binding pocket [chemical binding]; other site 1294143013328 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1294143013329 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1294143013330 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1294143013331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143013332 S-adenosylmethionine binding site [chemical binding]; other site 1294143013333 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143013334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143013335 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1294143013336 Ligand binding site; other site 1294143013337 metal-binding site 1294143013338 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1294143013339 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1294143013340 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1294143013341 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1294143013342 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1294143013343 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143013344 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1294143013345 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1294143013346 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1294143013347 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1294143013348 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1294143013349 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1294143013350 H+ Antiporter protein; Region: 2A0121; TIGR00900 1294143013351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143013352 putative substrate translocation pore; other site 1294143013353 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1294143013354 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1294143013355 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1294143013356 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1294143013357 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1294143013358 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1294143013359 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1294143013360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143013361 Walker A motif; other site 1294143013362 ATP binding site [chemical binding]; other site 1294143013363 Walker B motif; other site 1294143013364 BCCT family transporter; Region: BCCT; cl00569 1294143013365 Predicted membrane protein [Function unknown]; Region: COG1297 1294143013366 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1294143013367 EamA-like transporter family; Region: EamA; pfam00892 1294143013368 EamA-like transporter family; Region: EamA; pfam00892 1294143013369 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1294143013370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143013371 putative DNA binding site [nucleotide binding]; other site 1294143013372 putative Zn2+ binding site [ion binding]; other site 1294143013373 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143013374 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1294143013375 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1294143013376 dimer interface [polypeptide binding]; other site 1294143013377 active site 1294143013378 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1294143013379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143013380 NAD(P) binding site [chemical binding]; other site 1294143013381 active site 1294143013382 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1294143013383 Ca2+ binding site [ion binding]; other site 1294143013384 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1294143013385 EF-hand domain pair; Region: EF_hand_5; pfam13499 1294143013386 Ca2+ binding site [ion binding]; other site 1294143013387 EF-hand domain pair; Region: EF_hand_5; pfam13499 1294143013388 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143013389 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143013390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143013391 enoyl-CoA hydratase; Region: PLN02864 1294143013392 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1294143013393 active site 2 [active] 1294143013394 active site 1 [active] 1294143013395 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1294143013396 homodimer interface [polypeptide binding]; other site 1294143013397 chemical substrate binding site [chemical binding]; other site 1294143013398 oligomer interface [polypeptide binding]; other site 1294143013399 metal binding site [ion binding]; metal-binding site 1294143013400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143013401 S-adenosylmethionine binding site [chemical binding]; other site 1294143013402 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1294143013403 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1294143013404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143013405 Coenzyme A binding pocket [chemical binding]; other site 1294143013406 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 1294143013407 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1294143013408 lipoyl attachment site [posttranslational modification]; other site 1294143013409 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1294143013410 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1294143013411 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1294143013412 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143013413 DNA binding site [nucleotide binding] 1294143013414 active site 1294143013415 Int/Topo IB signature motif; other site 1294143013416 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1294143013417 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1294143013418 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1294143013419 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1294143013420 G1 box; other site 1294143013421 putative GEF interaction site [polypeptide binding]; other site 1294143013422 GTP/Mg2+ binding site [chemical binding]; other site 1294143013423 Switch I region; other site 1294143013424 G2 box; other site 1294143013425 G3 box; other site 1294143013426 Switch II region; other site 1294143013427 G4 box; other site 1294143013428 G5 box; other site 1294143013429 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1294143013430 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1294143013431 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1294143013432 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1294143013433 selenocysteine synthase; Provisional; Region: PRK04311 1294143013434 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1294143013435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1294143013436 catalytic residue [active] 1294143013437 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 1294143013438 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1294143013439 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 1294143013440 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1294143013441 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1294143013442 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1294143013443 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143013444 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143013445 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1294143013446 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1294143013447 molybdopterin cofactor binding site; other site 1294143013448 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1294143013449 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1294143013450 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1294143013451 active site 1294143013452 FMN binding site [chemical binding]; other site 1294143013453 2,4-decadienoyl-CoA binding site; other site 1294143013454 catalytic residue [active] 1294143013455 4Fe-4S cluster binding site [ion binding]; other site 1294143013456 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1294143013457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143013458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1294143013459 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1294143013460 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1294143013461 active site 1294143013462 metal binding site [ion binding]; metal-binding site 1294143013463 nudix motif; other site 1294143013464 Flagellin N-methylase; Region: FliB; pfam03692 1294143013465 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1294143013466 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1294143013467 Predicted membrane protein [Function unknown]; Region: COG3556 1294143013468 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1294143013469 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1294143013470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143013471 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1294143013472 Predicted flavoprotein [General function prediction only]; Region: COG0431 1294143013473 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143013474 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1294143013475 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1294143013476 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1294143013477 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1294143013478 HSP70 interaction site [polypeptide binding]; other site 1294143013479 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1294143013480 substrate binding site [polypeptide binding]; other site 1294143013481 dimer interface [polypeptide binding]; other site 1294143013482 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143013483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143013484 DNA-binding site [nucleotide binding]; DNA binding site 1294143013485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143013486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143013487 homodimer interface [polypeptide binding]; other site 1294143013488 catalytic residue [active] 1294143013489 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1294143013490 ATP cone domain; Region: ATP-cone; pfam03477 1294143013491 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1294143013492 effector binding site; other site 1294143013493 active site 1294143013494 Zn binding site [ion binding]; other site 1294143013495 glycine loop; other site 1294143013496 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1294143013497 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1294143013498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1294143013499 FeS/SAM binding site; other site 1294143013500 arginine decarboxylase; Provisional; Region: PRK05354 1294143013501 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1294143013502 dimer interface [polypeptide binding]; other site 1294143013503 active site 1294143013504 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1294143013505 catalytic residues [active] 1294143013506 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1294143013507 translation initiation factor Sui1; Validated; Region: PRK06824 1294143013508 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1294143013509 putative rRNA binding site [nucleotide binding]; other site 1294143013510 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1294143013511 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1294143013512 nudix motif; other site 1294143013513 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1294143013514 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1294143013515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1294143013516 active site 1294143013517 phosphorylation site [posttranslational modification] 1294143013518 intermolecular recognition site; other site 1294143013519 dimerization interface [polypeptide binding]; other site 1294143013520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143013521 active site 1294143013522 phosphorylation site [posttranslational modification] 1294143013523 intermolecular recognition site; other site 1294143013524 dimerization interface [polypeptide binding]; other site 1294143013525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143013526 metal binding site [ion binding]; metal-binding site 1294143013527 active site 1294143013528 I-site; other site 1294143013529 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1294143013530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1294143013531 dimer interface [polypeptide binding]; other site 1294143013532 putative CheW interface [polypeptide binding]; other site 1294143013533 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1294143013534 agmatinase; Region: agmatinase; TIGR01230 1294143013535 oligomer interface [polypeptide binding]; other site 1294143013536 putative active site [active] 1294143013537 Mn binding site [ion binding]; other site 1294143013538 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143013539 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1294143013540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143013541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143013542 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143013543 dimerization interface [polypeptide binding]; other site 1294143013544 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1294143013545 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1294143013546 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1294143013547 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1294143013548 DsbD alpha interface [polypeptide binding]; other site 1294143013549 catalytic residues [active] 1294143013550 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1294143013551 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1294143013552 active site 1294143013553 trimer interface [polypeptide binding]; other site 1294143013554 dimer interface [polypeptide binding]; other site 1294143013555 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1294143013556 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1294143013557 carboxyltransferase (CT) interaction site; other site 1294143013558 biotinylation site [posttranslational modification]; other site 1294143013559 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1294143013560 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1294143013561 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1294143013562 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1294143013563 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1294143013564 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1294143013565 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1294143013566 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1294143013567 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1294143013568 FMN binding site [chemical binding]; other site 1294143013569 active site 1294143013570 catalytic residues [active] 1294143013571 substrate binding site [chemical binding]; other site 1294143013572 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1294143013573 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1294143013574 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1294143013575 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1294143013576 purine monophosphate binding site [chemical binding]; other site 1294143013577 dimer interface [polypeptide binding]; other site 1294143013578 putative catalytic residues [active] 1294143013579 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1294143013580 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1294143013581 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1294143013582 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1294143013583 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1294143013584 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1294143013585 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1294143013586 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1294143013587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143013588 dimer interface [polypeptide binding]; other site 1294143013589 phosphorylation site [posttranslational modification] 1294143013590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143013591 ATP binding site [chemical binding]; other site 1294143013592 Mg2+ binding site [ion binding]; other site 1294143013593 G-X-G motif; other site 1294143013594 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143013595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143013596 active site 1294143013597 phosphorylation site [posttranslational modification] 1294143013598 intermolecular recognition site; other site 1294143013599 dimerization interface [polypeptide binding]; other site 1294143013600 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143013601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143013602 active site 1294143013603 phosphorylation site [posttranslational modification] 1294143013604 intermolecular recognition site; other site 1294143013605 dimerization interface [polypeptide binding]; other site 1294143013606 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1294143013607 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1294143013608 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1294143013609 putative ligand binding site [chemical binding]; other site 1294143013610 HEAT repeats; Region: HEAT_2; pfam13646 1294143013611 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1294143013612 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1294143013613 TM-ABC transporter signature motif; other site 1294143013614 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1294143013615 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1294143013616 TM-ABC transporter signature motif; other site 1294143013617 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1294143013618 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1294143013619 Walker A/P-loop; other site 1294143013620 ATP binding site [chemical binding]; other site 1294143013621 Q-loop/lid; other site 1294143013622 ABC transporter signature motif; other site 1294143013623 Walker B; other site 1294143013624 D-loop; other site 1294143013625 H-loop/switch region; other site 1294143013626 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1294143013627 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1294143013628 Walker A/P-loop; other site 1294143013629 ATP binding site [chemical binding]; other site 1294143013630 Q-loop/lid; other site 1294143013631 ABC transporter signature motif; other site 1294143013632 Walker B; other site 1294143013633 D-loop; other site 1294143013634 H-loop/switch region; other site 1294143013635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143013636 Coenzyme A binding pocket [chemical binding]; other site 1294143013637 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1294143013638 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1294143013639 alpha-gamma subunit interface [polypeptide binding]; other site 1294143013640 beta-gamma subunit interface [polypeptide binding]; other site 1294143013641 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1294143013642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143013643 Coenzyme A binding pocket [chemical binding]; other site 1294143013644 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1294143013645 gamma-beta subunit interface [polypeptide binding]; other site 1294143013646 alpha-beta subunit interface [polypeptide binding]; other site 1294143013647 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1294143013648 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1294143013649 subunit interactions [polypeptide binding]; other site 1294143013650 active site 1294143013651 flap region; other site 1294143013652 hypothetical protein; Provisional; Region: PRK11019 1294143013653 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1294143013654 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1294143013655 tetramer interface [polypeptide binding]; other site 1294143013656 active site 1294143013657 Mg2+/Mn2+ binding site [ion binding]; other site 1294143013658 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1294143013659 putative chaperone; Provisional; Region: PRK11678 1294143013660 nucleotide binding site [chemical binding]; other site 1294143013661 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1294143013662 SBD interface [polypeptide binding]; other site 1294143013663 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1294143013664 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1294143013665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1294143013666 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1294143013667 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1294143013668 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 1294143013669 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1294143013670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143013671 Coenzyme A binding pocket [chemical binding]; other site 1294143013672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143013673 putative MFS family transporter protein; Provisional; Region: PRK03633 1294143013674 putative substrate translocation pore; other site 1294143013675 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1294143013676 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1294143013677 putative di-iron ligands [ion binding]; other site 1294143013678 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1294143013679 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1294143013680 FAD binding pocket [chemical binding]; other site 1294143013681 FAD binding motif [chemical binding]; other site 1294143013682 phosphate binding motif [ion binding]; other site 1294143013683 beta-alpha-beta structure motif; other site 1294143013684 NAD binding pocket [chemical binding]; other site 1294143013685 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143013686 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1294143013687 catalytic loop [active] 1294143013688 iron binding site [ion binding]; other site 1294143013689 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1294143013690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143013691 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1294143013692 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1294143013693 dimer interface [polypeptide binding]; other site 1294143013694 catalytic residues [active] 1294143013695 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1294143013696 UreF; Region: UreF; pfam01730 1294143013697 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1294143013698 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1294143013699 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143013700 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1294143013701 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1294143013702 NAD(P) binding site [chemical binding]; other site 1294143013703 catalytic residues [active] 1294143013704 benzoate transport; Region: 2A0115; TIGR00895 1294143013705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143013706 putative substrate translocation pore; other site 1294143013707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143013708 putative substrate translocation pore; other site 1294143013709 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1294143013710 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1294143013711 PYR/PP interface [polypeptide binding]; other site 1294143013712 dimer interface [polypeptide binding]; other site 1294143013713 TPP binding site [chemical binding]; other site 1294143013714 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1294143013715 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1294143013716 TPP-binding site [chemical binding]; other site 1294143013717 dimer interface [polypeptide binding]; other site 1294143013718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143013719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143013720 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1294143013721 substrate binding pocket [chemical binding]; other site 1294143013722 dimerization interface [polypeptide binding]; other site 1294143013723 benzoate transport; Region: 2A0115; TIGR00895 1294143013724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143013725 putative substrate translocation pore; other site 1294143013726 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1294143013727 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1294143013728 iron-sulfur cluster [ion binding]; other site 1294143013729 [2Fe-2S] cluster binding site [ion binding]; other site 1294143013730 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1294143013731 alpha subunit interface [polypeptide binding]; other site 1294143013732 active site 1294143013733 substrate binding site [chemical binding]; other site 1294143013734 Fe binding site [ion binding]; other site 1294143013735 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1294143013736 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1294143013737 FMN-binding pocket [chemical binding]; other site 1294143013738 flavin binding motif; other site 1294143013739 phosphate binding motif [ion binding]; other site 1294143013740 beta-alpha-beta structure motif; other site 1294143013741 NAD binding pocket [chemical binding]; other site 1294143013742 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143013743 catalytic loop [active] 1294143013744 iron binding site [ion binding]; other site 1294143013745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143013746 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1294143013747 DNA-binding site [nucleotide binding]; DNA binding site 1294143013748 FCD domain; Region: FCD; pfam07729 1294143013749 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1294143013750 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1294143013751 putative NAD(P) binding site [chemical binding]; other site 1294143013752 homodimer interface [polypeptide binding]; other site 1294143013753 homotetramer interface [polypeptide binding]; other site 1294143013754 active site 1294143013755 ornithine cyclodeaminase; Validated; Region: PRK06141 1294143013756 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1294143013757 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1294143013758 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1294143013759 Walker A/P-loop; other site 1294143013760 ATP binding site [chemical binding]; other site 1294143013761 Q-loop/lid; other site 1294143013762 ABC transporter signature motif; other site 1294143013763 Walker B; other site 1294143013764 D-loop; other site 1294143013765 H-loop/switch region; other site 1294143013766 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1294143013767 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1294143013768 Walker A/P-loop; other site 1294143013769 ATP binding site [chemical binding]; other site 1294143013770 Q-loop/lid; other site 1294143013771 ABC transporter signature motif; other site 1294143013772 Walker B; other site 1294143013773 D-loop; other site 1294143013774 H-loop/switch region; other site 1294143013775 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1294143013776 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1294143013777 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1294143013778 TM-ABC transporter signature motif; other site 1294143013779 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1294143013780 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1294143013781 TM-ABC transporter signature motif; other site 1294143013782 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1294143013783 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1294143013784 dimerization interface [polypeptide binding]; other site 1294143013785 ligand binding site [chemical binding]; other site 1294143013786 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143013787 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143013788 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1294143013789 aldehyde dehydrogenase family 7 member; Region: PLN02315 1294143013790 tetrameric interface [polypeptide binding]; other site 1294143013791 NAD binding site [chemical binding]; other site 1294143013792 catalytic residues [active] 1294143013793 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143013794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143013795 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1294143013796 dimerization interface [polypeptide binding]; other site 1294143013797 substrate binding pocket [chemical binding]; other site 1294143013798 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1294143013799 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1294143013800 homodimer interface [polypeptide binding]; other site 1294143013801 NAD binding pocket [chemical binding]; other site 1294143013802 ATP binding pocket [chemical binding]; other site 1294143013803 Mg binding site [ion binding]; other site 1294143013804 active-site loop [active] 1294143013805 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1294143013806 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1294143013807 Azurin [Energy production and conversion]; Region: COG3241 1294143013808 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1294143013809 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1294143013810 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1294143013811 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1294143013812 PilX N-terminal; Region: PilX_N; pfam14341 1294143013813 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1294143013814 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1294143013815 mechanosensitive channel MscS; Provisional; Region: PRK10334 1294143013816 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1294143013817 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 1294143013818 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 1294143013819 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 1294143013820 hypothetical protein; Provisional; Region: PRK01254 1294143013821 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1294143013822 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1294143013823 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1294143013824 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1294143013825 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1294143013826 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143013827 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143013828 metal binding site [ion binding]; metal-binding site 1294143013829 active site 1294143013830 I-site; other site 1294143013831 alanine racemase; Reviewed; Region: alr; PRK00053 1294143013832 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1294143013833 active site 1294143013834 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1294143013835 substrate binding site [chemical binding]; other site 1294143013836 catalytic residues [active] 1294143013837 dimer interface [polypeptide binding]; other site 1294143013838 replicative DNA helicase; Provisional; Region: PRK05748 1294143013839 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1294143013840 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1294143013841 Walker A motif; other site 1294143013842 ATP binding site [chemical binding]; other site 1294143013843 Walker B motif; other site 1294143013844 DNA binding loops [nucleotide binding] 1294143013845 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1294143013846 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1294143013847 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1294143013848 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1294143013849 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1294143013850 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1294143013851 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1294143013852 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1294143013853 ribonuclease R; Region: RNase_R; TIGR02063 1294143013854 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1294143013855 RNB domain; Region: RNB; pfam00773 1294143013856 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1294143013857 RNA binding site [nucleotide binding]; other site 1294143013858 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1294143013859 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1294143013860 GDP-binding site [chemical binding]; other site 1294143013861 ACT binding site; other site 1294143013862 IMP binding site; other site 1294143013863 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1294143013864 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1294143013865 dimer interface [polypeptide binding]; other site 1294143013866 motif 1; other site 1294143013867 active site 1294143013868 motif 2; other site 1294143013869 motif 3; other site 1294143013870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1294143013871 FtsH protease regulator HflC; Provisional; Region: PRK11029 1294143013872 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1294143013873 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1294143013874 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1294143013875 HflK protein; Region: hflK; TIGR01933 1294143013876 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1294143013877 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1294143013878 HflX GTPase family; Region: HflX; cd01878 1294143013879 G1 box; other site 1294143013880 GTP/Mg2+ binding site [chemical binding]; other site 1294143013881 Switch I region; other site 1294143013882 G2 box; other site 1294143013883 G3 box; other site 1294143013884 Switch II region; other site 1294143013885 G4 box; other site 1294143013886 G5 box; other site 1294143013887 bacterial Hfq-like; Region: Hfq; cd01716 1294143013888 hexamer interface [polypeptide binding]; other site 1294143013889 Sm1 motif; other site 1294143013890 RNA binding site [nucleotide binding]; other site 1294143013891 Sm2 motif; other site 1294143013892 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1294143013893 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1294143013894 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1294143013895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143013896 ATP binding site [chemical binding]; other site 1294143013897 Mg2+ binding site [ion binding]; other site 1294143013898 G-X-G motif; other site 1294143013899 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1294143013900 ATP binding site [chemical binding]; other site 1294143013901 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1294143013902 AMIN domain; Region: AMIN; pfam11741 1294143013903 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1294143013904 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1294143013905 active site 1294143013906 metal binding site [ion binding]; metal-binding site 1294143013907 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1294143013908 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1294143013909 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1294143013910 putative carbohydrate kinase; Provisional; Region: PRK10565 1294143013911 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1294143013912 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1294143013913 putative substrate binding site [chemical binding]; other site 1294143013914 putative ATP binding site [chemical binding]; other site 1294143013915 epoxyqueuosine reductase; Region: TIGR00276 1294143013916 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1294143013917 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1294143013918 catalytic site [active] 1294143013919 putative active site [active] 1294143013920 putative substrate binding site [chemical binding]; other site 1294143013921 dimer interface [polypeptide binding]; other site 1294143013922 GTPase RsgA; Reviewed; Region: PRK12288 1294143013923 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1294143013924 RNA binding site [nucleotide binding]; other site 1294143013925 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1294143013926 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1294143013927 GTP/Mg2+ binding site [chemical binding]; other site 1294143013928 G4 box; other site 1294143013929 G5 box; other site 1294143013930 G1 box; other site 1294143013931 Switch I region; other site 1294143013932 G2 box; other site 1294143013933 G3 box; other site 1294143013934 Switch II region; other site 1294143013935 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1294143013936 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1294143013937 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1294143013938 ligand binding site [chemical binding]; other site 1294143013939 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1294143013940 flagellar motor protein MotA; Validated; Region: PRK09110 1294143013941 HDOD domain; Region: HDOD; pfam08668 1294143013942 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1294143013943 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1294143013944 active site residue [active] 1294143013945 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1294143013946 active site residue [active] 1294143013947 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1294143013948 HPP family; Region: HPP; pfam04982 1294143013949 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 1294143013950 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143013951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143013952 active site 1294143013953 phosphorylation site [posttranslational modification] 1294143013954 intermolecular recognition site; other site 1294143013955 dimerization interface [polypeptide binding]; other site 1294143013956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143013957 putative active site [active] 1294143013958 heme pocket [chemical binding]; other site 1294143013959 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143013960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143013961 metal binding site [ion binding]; metal-binding site 1294143013962 active site 1294143013963 I-site; other site 1294143013964 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143013965 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1294143013966 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1294143013967 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1294143013968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143013969 motif II; other site 1294143013970 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 1294143013971 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1294143013972 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1294143013973 putative active site [active] 1294143013974 putative metal binding site [ion binding]; other site 1294143013975 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1294143013976 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1294143013977 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1294143013978 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1294143013979 CAP-like domain; other site 1294143013980 active site 1294143013981 primary dimer interface [polypeptide binding]; other site 1294143013982 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1294143013983 catalytic motif [active] 1294143013984 Catalytic residue [active] 1294143013985 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1294143013986 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1294143013987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143013988 ATP binding site [chemical binding]; other site 1294143013989 Mg2+ binding site [ion binding]; other site 1294143013990 G-X-G motif; other site 1294143013991 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1294143013992 anchoring element; other site 1294143013993 dimer interface [polypeptide binding]; other site 1294143013994 ATP binding site [chemical binding]; other site 1294143013995 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1294143013996 active site 1294143013997 metal binding site [ion binding]; metal-binding site 1294143013998 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1294143013999 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143014000 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1294143014001 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1294143014002 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1294143014003 active site 1294143014004 metal binding site [ion binding]; metal-binding site 1294143014005 hexamer interface [polypeptide binding]; other site 1294143014006 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 1294143014007 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1294143014008 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1294143014009 dimer interface [polypeptide binding]; other site 1294143014010 ADP-ribose binding site [chemical binding]; other site 1294143014011 active site 1294143014012 nudix motif; other site 1294143014013 metal binding site [ion binding]; metal-binding site 1294143014014 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1294143014015 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1294143014016 Na binding site [ion binding]; other site 1294143014017 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1294143014018 ThiC-associated domain; Region: ThiC-associated; pfam13667 1294143014019 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1294143014020 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1294143014021 aldolase II superfamily protein; Provisional; Region: PRK07044 1294143014022 intersubunit interface [polypeptide binding]; other site 1294143014023 active site 1294143014024 Zn2+ binding site [ion binding]; other site 1294143014025 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143014026 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143014027 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1294143014028 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1294143014029 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1294143014030 putative active site [active] 1294143014031 putative FMN binding site [chemical binding]; other site 1294143014032 putative substrate binding site [chemical binding]; other site 1294143014033 putative catalytic residue [active] 1294143014034 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1294143014035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143014036 non-specific DNA binding site [nucleotide binding]; other site 1294143014037 salt bridge; other site 1294143014038 sequence-specific DNA binding site [nucleotide binding]; other site 1294143014039 Cupin domain; Region: Cupin_2; pfam07883 1294143014040 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1294143014041 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1294143014042 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1294143014043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143014044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143014045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143014046 dimerization interface [polypeptide binding]; other site 1294143014047 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1294143014048 FAD dependent oxidoreductase; Region: DAO; pfam01266 1294143014049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143014050 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1294143014051 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1294143014052 active site 1294143014053 catalytic tetrad [active] 1294143014054 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143014055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143014056 active site 1294143014057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143014058 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143014059 active site 1294143014060 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1294143014061 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1294143014062 putative ribose interaction site [chemical binding]; other site 1294143014063 putative ADP binding site [chemical binding]; other site 1294143014064 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1294143014065 active site 1294143014066 nucleotide binding site [chemical binding]; other site 1294143014067 HIGH motif; other site 1294143014068 KMSKS motif; other site 1294143014069 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1294143014070 Mig-14; Region: Mig-14; pfam07395 1294143014071 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1294143014072 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1294143014073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1294143014074 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1294143014075 Walker A/P-loop; other site 1294143014076 ATP binding site [chemical binding]; other site 1294143014077 Q-loop/lid; other site 1294143014078 ABC transporter signature motif; other site 1294143014079 Walker B; other site 1294143014080 D-loop; other site 1294143014081 H-loop/switch region; other site 1294143014082 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1294143014083 active site 1294143014084 ATP binding site [chemical binding]; other site 1294143014085 O-Antigen ligase; Region: Wzy_C; pfam04932 1294143014086 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1294143014087 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1294143014088 active site 1294143014089 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143014090 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1294143014091 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1294143014092 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1294143014093 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1294143014094 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1294143014095 Ligand binding site; other site 1294143014096 oligomer interface; other site 1294143014097 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 1294143014098 active site 1294143014099 catalytic residues [active] 1294143014100 metal binding site [ion binding]; metal-binding site 1294143014101 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1294143014102 putative ADP-binding pocket [chemical binding]; other site 1294143014103 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143014104 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1294143014105 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1294143014106 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1294143014107 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 1294143014108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1294143014109 active site 1294143014110 ATP binding site [chemical binding]; other site 1294143014111 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1294143014112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143014113 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1294143014114 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1294143014115 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1294143014116 putative active site [active] 1294143014117 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1294143014118 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1294143014119 putative active site [active] 1294143014120 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1294143014121 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1294143014122 metal binding triad; other site 1294143014123 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1294143014124 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1294143014125 metal binding triad; other site 1294143014126 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1294143014127 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1294143014128 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1294143014129 dimer interface [polypeptide binding]; other site 1294143014130 TPP-binding site [chemical binding]; other site 1294143014131 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1294143014132 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348 1294143014133 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1294143014134 E3 interaction surface; other site 1294143014135 lipoyl attachment site [posttranslational modification]; other site 1294143014136 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1294143014137 E3 interaction surface; other site 1294143014138 lipoyl attachment site [posttranslational modification]; other site 1294143014139 e3 binding domain; Region: E3_binding; pfam02817 1294143014140 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1294143014141 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1294143014142 GAF domain; Region: GAF; pfam01590 1294143014143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143014144 PAS domain; Region: PAS_9; pfam13426 1294143014145 putative active site [active] 1294143014146 heme pocket [chemical binding]; other site 1294143014147 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143014148 metal binding site [ion binding]; metal-binding site 1294143014149 active site 1294143014150 I-site; other site 1294143014151 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143014152 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1294143014153 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1294143014154 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1294143014155 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143014156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143014157 active site 1294143014158 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143014159 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1294143014160 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1294143014161 TrkA-C domain; Region: TrkA_C; pfam02080 1294143014162 Transporter associated domain; Region: CorC_HlyC; smart01091 1294143014163 hypothetical protein; Provisional; Region: PRK11281 1294143014164 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1294143014165 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1294143014166 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1294143014167 hypothetical protein; Validated; Region: PRK00029 1294143014168 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1294143014169 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1294143014170 homodimer interface [polypeptide binding]; other site 1294143014171 substrate-cofactor binding pocket; other site 1294143014172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143014173 catalytic residue [active] 1294143014174 thioredoxin 2; Provisional; Region: PRK10996 1294143014175 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1294143014176 catalytic residues [active] 1294143014177 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143014178 CoenzymeA binding site [chemical binding]; other site 1294143014179 subunit interaction site [polypeptide binding]; other site 1294143014180 PHB binding site; other site 1294143014181 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143014182 Ligand Binding Site [chemical binding]; other site 1294143014183 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1294143014184 Ligand Binding Site [chemical binding]; other site 1294143014185 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1294143014186 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1294143014187 P-loop; other site 1294143014188 Magnesium ion binding site [ion binding]; other site 1294143014189 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1294143014190 Magnesium ion binding site [ion binding]; other site 1294143014191 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1294143014192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143014193 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1294143014194 dimerization interface [polypeptide binding]; other site 1294143014195 substrate binding pocket [chemical binding]; other site 1294143014196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143014197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143014198 putative substrate translocation pore; other site 1294143014199 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1294143014200 Spore germination protein; Region: Spore_permease; cl17796 1294143014201 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1294143014202 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1294143014203 substrate binding site [chemical binding]; other site 1294143014204 active site 1294143014205 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1294143014206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143014207 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1294143014208 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1294143014209 active site 1294143014210 dimer interface [polypeptide binding]; other site 1294143014211 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1294143014212 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1294143014213 active site 1294143014214 FMN binding site [chemical binding]; other site 1294143014215 substrate binding site [chemical binding]; other site 1294143014216 3Fe-4S cluster binding site [ion binding]; other site 1294143014217 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1294143014218 domain interface; other site 1294143014219 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1294143014220 Sporulation related domain; Region: SPOR; pfam05036 1294143014221 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1294143014222 active site 1294143014223 dimer interface [polypeptide binding]; other site 1294143014224 metal binding site [ion binding]; metal-binding site 1294143014225 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1294143014226 Shikimate kinase; Region: SKI; pfam01202 1294143014227 ADP binding site [chemical binding]; other site 1294143014228 magnesium binding site [ion binding]; other site 1294143014229 putative shikimate binding site; other site 1294143014230 AMIN domain; Region: AMIN; pfam11741 1294143014231 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1294143014232 Secretin and TonB N terminus short domain; Region: STN; smart00965 1294143014233 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1294143014234 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1294143014235 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 1294143014236 Pilus assembly protein, PilP; Region: PilP; pfam04351 1294143014237 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 1294143014238 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1294143014239 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1294143014240 Competence protein A; Region: Competence_A; pfam11104 1294143014241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1294143014242 nucleotide binding site [chemical binding]; other site 1294143014243 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1294143014244 Transglycosylase; Region: Transgly; pfam00912 1294143014245 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1294143014246 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1294143014247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143014248 S-adenosylmethionine binding site [chemical binding]; other site 1294143014249 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1294143014250 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1294143014251 intersubunit interface [polypeptide binding]; other site 1294143014252 active site 1294143014253 zinc binding site [ion binding]; other site 1294143014254 Na+ binding site [ion binding]; other site 1294143014255 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1294143014256 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1294143014257 Phosphoglycerate kinase; Region: PGK; pfam00162 1294143014258 substrate binding site [chemical binding]; other site 1294143014259 hinge regions; other site 1294143014260 ADP binding site [chemical binding]; other site 1294143014261 catalytic site [active] 1294143014262 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1294143014263 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1294143014264 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1294143014265 transketolase; Reviewed; Region: PRK12753 1294143014266 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1294143014267 TPP-binding site [chemical binding]; other site 1294143014268 dimer interface [polypeptide binding]; other site 1294143014269 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1294143014270 PYR/PP interface [polypeptide binding]; other site 1294143014271 dimer interface [polypeptide binding]; other site 1294143014272 TPP binding site [chemical binding]; other site 1294143014273 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1294143014274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143014275 putative DNA binding site [nucleotide binding]; other site 1294143014276 putative Zn2+ binding site [ion binding]; other site 1294143014277 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1294143014278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143014279 S-adenosylmethionine binding site [chemical binding]; other site 1294143014280 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1294143014281 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1294143014282 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1294143014283 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1294143014284 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1294143014285 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1294143014286 nucleotide binding pocket [chemical binding]; other site 1294143014287 K-X-D-G motif; other site 1294143014288 catalytic site [active] 1294143014289 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1294143014290 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1294143014291 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1294143014292 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1294143014293 FAD binding pocket [chemical binding]; other site 1294143014294 FAD binding motif [chemical binding]; other site 1294143014295 phosphate binding motif [ion binding]; other site 1294143014296 beta-alpha-beta structure motif; other site 1294143014297 NAD binding pocket [chemical binding]; other site 1294143014298 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1294143014299 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1294143014300 putative active site [active] 1294143014301 putative metal binding site [ion binding]; other site 1294143014302 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1294143014303 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1294143014304 nucleophilic elbow; other site 1294143014305 catalytic triad; other site 1294143014306 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1294143014307 Cytochrome c556 [Energy production and conversion]; Region: COG3909 1294143014308 Predicted membrane protein [Function unknown]; Region: COG3686 1294143014309 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1294143014310 EamA-like transporter family; Region: EamA; pfam00892 1294143014311 LemA family; Region: LemA; pfam04011 1294143014312 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1294143014313 Repair protein; Region: Repair_PSII; pfam04536 1294143014314 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1294143014315 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1294143014316 Walker A/P-loop; other site 1294143014317 ATP binding site [chemical binding]; other site 1294143014318 Q-loop/lid; other site 1294143014319 ABC transporter signature motif; other site 1294143014320 Walker B; other site 1294143014321 D-loop; other site 1294143014322 H-loop/switch region; other site 1294143014323 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1294143014324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014325 dimer interface [polypeptide binding]; other site 1294143014326 conserved gate region; other site 1294143014327 putative PBP binding loops; other site 1294143014328 ABC-ATPase subunit interface; other site 1294143014329 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1294143014330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143014331 substrate binding pocket [chemical binding]; other site 1294143014332 membrane-bound complex binding site; other site 1294143014333 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1294143014334 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143014335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143014336 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1294143014337 dimerization interface [polypeptide binding]; other site 1294143014338 substrate binding pocket [chemical binding]; other site 1294143014339 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1294143014340 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143014341 FAD binding site [chemical binding]; other site 1294143014342 substrate binding pocket [chemical binding]; other site 1294143014343 catalytic base [active] 1294143014344 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1294143014345 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1294143014346 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1294143014347 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1294143014348 homotetramer interface [polypeptide binding]; other site 1294143014349 ligand binding site [chemical binding]; other site 1294143014350 catalytic site [active] 1294143014351 NAD binding site [chemical binding]; other site 1294143014352 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1294143014353 FAD binding site [chemical binding]; other site 1294143014354 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1294143014355 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1294143014356 ATP binding site [chemical binding]; other site 1294143014357 Mg++ binding site [ion binding]; other site 1294143014358 motif III; other site 1294143014359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143014360 nucleotide binding region [chemical binding]; other site 1294143014361 ATP-binding site [chemical binding]; other site 1294143014362 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1294143014363 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143014364 Walker A/P-loop; other site 1294143014365 ATP binding site [chemical binding]; other site 1294143014366 Q-loop/lid; other site 1294143014367 ABC transporter signature motif; other site 1294143014368 Walker B; other site 1294143014369 D-loop; other site 1294143014370 H-loop/switch region; other site 1294143014371 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143014372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014373 dimer interface [polypeptide binding]; other site 1294143014374 conserved gate region; other site 1294143014375 putative PBP binding loops; other site 1294143014376 ABC-ATPase subunit interface; other site 1294143014377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143014378 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143014379 substrate binding pocket [chemical binding]; other site 1294143014380 membrane-bound complex binding site; other site 1294143014381 hinge residues; other site 1294143014382 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1294143014383 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1294143014384 Ligand binding site; other site 1294143014385 DXD motif; other site 1294143014386 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1294143014387 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1294143014388 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1294143014389 putative active site [active] 1294143014390 dimerization interface [polypeptide binding]; other site 1294143014391 putative tRNAtyr binding site [nucleotide binding]; other site 1294143014392 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1294143014393 TAP-like protein; Region: Abhydrolase_4; pfam08386 1294143014394 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1294143014395 nudix motif; other site 1294143014396 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1294143014397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143014398 substrate binding pocket [chemical binding]; other site 1294143014399 membrane-bound complex binding site; other site 1294143014400 hinge residues; other site 1294143014401 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1294143014402 homotrimer interaction site [polypeptide binding]; other site 1294143014403 putative active site [active] 1294143014404 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1294143014405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143014406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143014407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143014408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143014409 dimerization interface [polypeptide binding]; other site 1294143014410 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1294143014411 imidazolonepropionase; Validated; Region: PRK09356 1294143014412 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1294143014413 active site 1294143014414 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1294143014415 active sites [active] 1294143014416 tetramer interface [polypeptide binding]; other site 1294143014417 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1294143014418 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1294143014419 Walker A/P-loop; other site 1294143014420 ATP binding site [chemical binding]; other site 1294143014421 Q-loop/lid; other site 1294143014422 ABC transporter signature motif; other site 1294143014423 Walker B; other site 1294143014424 D-loop; other site 1294143014425 H-loop/switch region; other site 1294143014426 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1294143014427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014428 dimer interface [polypeptide binding]; other site 1294143014429 conserved gate region; other site 1294143014430 putative PBP binding loops; other site 1294143014431 ABC-ATPase subunit interface; other site 1294143014432 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1294143014433 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1294143014434 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1294143014435 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1294143014436 Na binding site [ion binding]; other site 1294143014437 urocanate hydratase; Provisional; Region: PRK05414 1294143014438 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1294143014439 active sites [active] 1294143014440 tetramer interface [polypeptide binding]; other site 1294143014441 HutD; Region: HutD; pfam05962 1294143014442 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1294143014443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143014444 DNA-binding site [nucleotide binding]; DNA binding site 1294143014445 UTRA domain; Region: UTRA; pfam07702 1294143014446 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1294143014447 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1294143014448 active site 1294143014449 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1294143014450 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1294143014451 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1294143014452 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1294143014453 AMP binding site [chemical binding]; other site 1294143014454 metal binding site [ion binding]; metal-binding site 1294143014455 active site 1294143014456 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1294143014457 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1294143014458 active site 1294143014459 catalytic triad [active] 1294143014460 oxyanion hole [active] 1294143014461 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1294143014462 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1294143014463 Predicted membrane protein [Function unknown]; Region: COG5373 1294143014464 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1294143014465 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1294143014466 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1294143014467 G1 box; other site 1294143014468 putative GEF interaction site [polypeptide binding]; other site 1294143014469 GTP/Mg2+ binding site [chemical binding]; other site 1294143014470 Switch I region; other site 1294143014471 G2 box; other site 1294143014472 G3 box; other site 1294143014473 Switch II region; other site 1294143014474 G4 box; other site 1294143014475 G5 box; other site 1294143014476 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1294143014477 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1294143014478 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1294143014479 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1294143014480 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1294143014481 Ligand Binding Site [chemical binding]; other site 1294143014482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1294143014483 active site residue [active] 1294143014484 glutamine synthetase; Provisional; Region: glnA; PRK09469 1294143014485 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1294143014486 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1294143014487 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1294143014488 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1294143014489 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1294143014490 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1294143014491 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1294143014492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143014493 putative active site [active] 1294143014494 heme pocket [chemical binding]; other site 1294143014495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143014496 dimer interface [polypeptide binding]; other site 1294143014497 phosphorylation site [posttranslational modification] 1294143014498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143014499 ATP binding site [chemical binding]; other site 1294143014500 Mg2+ binding site [ion binding]; other site 1294143014501 G-X-G motif; other site 1294143014502 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1294143014503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143014504 active site 1294143014505 phosphorylation site [posttranslational modification] 1294143014506 intermolecular recognition site; other site 1294143014507 dimerization interface [polypeptide binding]; other site 1294143014508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143014509 Walker A motif; other site 1294143014510 ATP binding site [chemical binding]; other site 1294143014511 Walker B motif; other site 1294143014512 arginine finger; other site 1294143014513 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143014514 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1294143014515 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1294143014516 SecA binding site; other site 1294143014517 Preprotein binding site; other site 1294143014518 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1294143014519 GSH binding site [chemical binding]; other site 1294143014520 catalytic residues [active] 1294143014521 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1294143014522 active site residue [active] 1294143014523 phosphoglyceromutase; Provisional; Region: PRK05434 1294143014524 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1294143014525 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1294143014526 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 1294143014527 Peptidase family M23; Region: Peptidase_M23; pfam01551 1294143014528 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1294143014529 C-terminal peptidase (prc); Region: prc; TIGR00225 1294143014530 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1294143014531 protein binding site [polypeptide binding]; other site 1294143014532 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1294143014533 Catalytic dyad [active] 1294143014534 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1294143014535 NodB motif; other site 1294143014536 putative active site [active] 1294143014537 putative catalytic site [active] 1294143014538 Zn binding site [ion binding]; other site 1294143014539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143014540 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143014541 substrate binding pocket [chemical binding]; other site 1294143014542 membrane-bound complex binding site; other site 1294143014543 hinge residues; other site 1294143014544 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1294143014545 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143014546 substrate binding pocket [chemical binding]; other site 1294143014547 membrane-bound complex binding site; other site 1294143014548 hinge residues; other site 1294143014549 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1294143014550 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1294143014551 substrate binding site [chemical binding]; other site 1294143014552 glutamase interaction surface [polypeptide binding]; other site 1294143014553 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1294143014554 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1294143014555 catalytic residues [active] 1294143014556 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1294143014557 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1294143014558 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1294143014559 putative active site [active] 1294143014560 oxyanion strand; other site 1294143014561 catalytic triad [active] 1294143014562 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1294143014563 putative active site pocket [active] 1294143014564 4-fold oligomerization interface [polypeptide binding]; other site 1294143014565 metal binding residues [ion binding]; metal-binding site 1294143014566 3-fold/trimer interface [polypeptide binding]; other site 1294143014567 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1294143014568 AsmA family; Region: AsmA; pfam05170 1294143014569 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1294143014570 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1294143014571 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1294143014572 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1294143014573 minor groove reading motif; other site 1294143014574 helix-hairpin-helix signature motif; other site 1294143014575 substrate binding pocket [chemical binding]; other site 1294143014576 active site 1294143014577 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1294143014578 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1294143014579 DNA binding and oxoG recognition site [nucleotide binding] 1294143014580 oxidative damage protection protein; Provisional; Region: PRK05408 1294143014581 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1294143014582 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1294143014583 active site 1294143014584 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 1294143014585 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1294143014586 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1294143014587 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1294143014588 putative transposase OrfB; Reviewed; Region: PHA02517 1294143014589 HTH-like domain; Region: HTH_21; pfam13276 1294143014590 Integrase core domain; Region: rve; pfam00665 1294143014591 Integrase core domain; Region: rve_2; pfam13333 1294143014592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1294143014593 Transposase; Region: HTH_Tnp_1; pfam01527 1294143014594 Sulfatase; Region: Sulfatase; pfam00884 1294143014595 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1294143014596 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1294143014597 Walker A/P-loop; other site 1294143014598 ATP binding site [chemical binding]; other site 1294143014599 Q-loop/lid; other site 1294143014600 ABC transporter signature motif; other site 1294143014601 Walker B; other site 1294143014602 D-loop; other site 1294143014603 H-loop/switch region; other site 1294143014604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1294143014605 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1294143014606 substrate binding pocket [chemical binding]; other site 1294143014607 membrane-bound complex binding site; other site 1294143014608 hinge residues; other site 1294143014609 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1294143014610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014611 dimer interface [polypeptide binding]; other site 1294143014612 conserved gate region; other site 1294143014613 putative PBP binding loops; other site 1294143014614 ABC-ATPase subunit interface; other site 1294143014615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014616 dimer interface [polypeptide binding]; other site 1294143014617 conserved gate region; other site 1294143014618 putative PBP binding loops; other site 1294143014619 ABC-ATPase subunit interface; other site 1294143014620 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1294143014621 MarR family; Region: MarR_2; cl17246 1294143014622 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1294143014623 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1294143014624 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1294143014625 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1294143014626 HlyD family secretion protein; Region: HlyD_3; pfam13437 1294143014627 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1294143014628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143014629 putative substrate translocation pore; other site 1294143014630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143014631 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1294143014632 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1294143014633 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1294143014634 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1294143014635 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1294143014636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1294143014637 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1294143014638 putative trimer interface [polypeptide binding]; other site 1294143014639 putative CoA binding site [chemical binding]; other site 1294143014640 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1294143014641 putative trimer interface [polypeptide binding]; other site 1294143014642 putative active site [active] 1294143014643 putative substrate binding site [chemical binding]; other site 1294143014644 putative CoA binding site [chemical binding]; other site 1294143014645 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1294143014646 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1294143014647 inhibitor-cofactor binding pocket; inhibition site 1294143014648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143014649 catalytic residue [active] 1294143014650 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1294143014651 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1294143014652 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1294143014653 active site 1294143014654 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1294143014655 homodimer interface [polypeptide binding]; other site 1294143014656 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1294143014657 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143014658 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1294143014659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1294143014660 active site 1294143014661 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1294143014662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143014663 active site 1294143014664 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1294143014665 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1294143014666 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1294143014667 NAD(P) binding site [chemical binding]; other site 1294143014668 homodimer interface [polypeptide binding]; other site 1294143014669 substrate binding site [chemical binding]; other site 1294143014670 active site 1294143014671 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1294143014672 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1294143014673 NAD binding site [chemical binding]; other site 1294143014674 substrate binding site [chemical binding]; other site 1294143014675 homodimer interface [polypeptide binding]; other site 1294143014676 active site 1294143014677 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1294143014678 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1294143014679 NADP binding site [chemical binding]; other site 1294143014680 active site 1294143014681 putative substrate binding site [chemical binding]; other site 1294143014682 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1294143014683 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1294143014684 substrate binding site; other site 1294143014685 tetramer interface; other site 1294143014686 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1294143014687 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1294143014688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143014689 dimer interface [polypeptide binding]; other site 1294143014690 phosphorylation site [posttranslational modification] 1294143014691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143014692 ATP binding site [chemical binding]; other site 1294143014693 G-X-G motif; other site 1294143014694 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1294143014695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143014696 active site 1294143014697 phosphorylation site [posttranslational modification] 1294143014698 intermolecular recognition site; other site 1294143014699 dimerization interface [polypeptide binding]; other site 1294143014700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143014701 Walker A motif; other site 1294143014702 ATP binding site [chemical binding]; other site 1294143014703 Walker B motif; other site 1294143014704 arginine finger; other site 1294143014705 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1294143014706 arginine deiminase; Provisional; Region: PRK01388 1294143014707 ornithine carbamoyltransferase; Validated; Region: PRK02102 1294143014708 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1294143014709 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1294143014710 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1294143014711 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1294143014712 putative substrate binding site [chemical binding]; other site 1294143014713 nucleotide binding site [chemical binding]; other site 1294143014714 nucleotide binding site [chemical binding]; other site 1294143014715 homodimer interface [polypeptide binding]; other site 1294143014716 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1294143014717 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1294143014718 active site 1294143014719 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1294143014720 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1294143014721 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1294143014722 proposed catalytic triad [active] 1294143014723 conserved cys residue [active] 1294143014724 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1294143014725 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1294143014726 putative RNA binding site [nucleotide binding]; other site 1294143014727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143014728 S-adenosylmethionine binding site [chemical binding]; other site 1294143014729 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1294143014730 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1294143014731 Pilin (bacterial filament); Region: Pilin; pfam00114 1294143014732 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1294143014733 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1294143014734 active site 1294143014735 metal binding site [ion binding]; metal-binding site 1294143014736 homotetramer interface [polypeptide binding]; other site 1294143014737 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1294143014738 G1 box; other site 1294143014739 GTP/Mg2+ binding site [chemical binding]; other site 1294143014740 G2 box; other site 1294143014741 Switch I region; other site 1294143014742 G3 box; other site 1294143014743 Switch II region; other site 1294143014744 G4 box; other site 1294143014745 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1294143014746 G5 box; other site 1294143014747 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1294143014748 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1294143014749 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1294143014750 folate binding site [chemical binding]; other site 1294143014751 NADP+ binding site [chemical binding]; other site 1294143014752 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1294143014753 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1294143014754 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143014755 active site 1294143014756 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1294143014757 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1294143014758 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143014759 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143014760 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143014761 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143014762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143014763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143014764 dimerization interface [polypeptide binding]; other site 1294143014765 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1294143014766 dimer interface [polypeptide binding]; other site 1294143014767 FMN binding site [chemical binding]; other site 1294143014768 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1294143014769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1294143014770 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1294143014771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143014772 ATP binding site [chemical binding]; other site 1294143014773 putative Mg++ binding site [ion binding]; other site 1294143014774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143014775 nucleotide binding region [chemical binding]; other site 1294143014776 ATP-binding site [chemical binding]; other site 1294143014777 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1294143014778 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1294143014779 active site 1294143014780 substrate-binding site [chemical binding]; other site 1294143014781 metal-binding site [ion binding] 1294143014782 ATP binding site [chemical binding]; other site 1294143014783 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1294143014784 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1294143014785 dimerization interface [polypeptide binding]; other site 1294143014786 domain crossover interface; other site 1294143014787 redox-dependent activation switch; other site 1294143014788 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1294143014789 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1294143014790 active site 1294143014791 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1294143014792 RNA binding surface [nucleotide binding]; other site 1294143014793 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1294143014794 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1294143014795 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1294143014796 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1294143014797 dimer interface [polypeptide binding]; other site 1294143014798 catalytic triad [active] 1294143014799 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1294143014800 HAMP domain; Region: HAMP; pfam00672 1294143014801 dimerization interface [polypeptide binding]; other site 1294143014802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143014803 ATP binding site [chemical binding]; other site 1294143014804 Mg2+ binding site [ion binding]; other site 1294143014805 G-X-G motif; other site 1294143014806 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1294143014807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143014808 active site 1294143014809 phosphorylation site [posttranslational modification] 1294143014810 intermolecular recognition site; other site 1294143014811 dimerization interface [polypeptide binding]; other site 1294143014812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143014813 DNA binding site [nucleotide binding] 1294143014814 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1294143014815 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1294143014816 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1294143014817 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1294143014818 RNA binding site [nucleotide binding]; other site 1294143014819 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1294143014820 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1294143014821 CoenzymeA binding site [chemical binding]; other site 1294143014822 subunit interaction site [polypeptide binding]; other site 1294143014823 PHB binding site; other site 1294143014824 glutamate--cysteine ligase; Provisional; Region: PRK02107 1294143014825 N-acetylglutamate synthase; Validated; Region: PRK05279 1294143014826 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1294143014827 putative feedback inhibition sensing region; other site 1294143014828 putative nucleotide binding site [chemical binding]; other site 1294143014829 putative substrate binding site [chemical binding]; other site 1294143014830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143014831 Coenzyme A binding pocket [chemical binding]; other site 1294143014832 acetylornithine deacetylase; Provisional; Region: PRK05111 1294143014833 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1294143014834 metal binding site [ion binding]; metal-binding site 1294143014835 putative dimer interface [polypeptide binding]; other site 1294143014836 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1294143014837 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1294143014838 putative active site; other site 1294143014839 putative metal binding residues [ion binding]; other site 1294143014840 signature motif; other site 1294143014841 putative triphosphate binding site [ion binding]; other site 1294143014842 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1294143014843 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1294143014844 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1294143014845 Walker A motif; other site 1294143014846 ATP binding site [chemical binding]; other site 1294143014847 Walker B motif; other site 1294143014848 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1294143014849 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1294143014850 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1294143014851 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1294143014852 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1294143014853 NRDE protein; Region: NRDE; cl01315 1294143014854 PAS fold; Region: PAS_3; pfam08447 1294143014855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143014856 putative active site [active] 1294143014857 heme pocket [chemical binding]; other site 1294143014858 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143014859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143014860 metal binding site [ion binding]; metal-binding site 1294143014861 active site 1294143014862 I-site; other site 1294143014863 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1294143014864 GAF domain; Region: GAF; pfam01590 1294143014865 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1294143014866 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1294143014867 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1294143014868 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1294143014869 putative active site [active] 1294143014870 Ap4A binding site [chemical binding]; other site 1294143014871 nudix motif; other site 1294143014872 putative metal binding site [ion binding]; other site 1294143014873 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1294143014874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143014875 motif II; other site 1294143014876 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1294143014877 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1294143014878 threonine dehydratase; Reviewed; Region: PRK09224 1294143014879 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1294143014880 tetramer interface [polypeptide binding]; other site 1294143014881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143014882 catalytic residue [active] 1294143014883 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1294143014884 putative Ile/Val binding site [chemical binding]; other site 1294143014885 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1294143014886 putative Ile/Val binding site [chemical binding]; other site 1294143014887 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1294143014888 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1294143014889 active site 1294143014890 dimer interface [polypeptide binding]; other site 1294143014891 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1294143014892 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1294143014893 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1294143014894 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1294143014895 metal binding site [ion binding]; metal-binding site 1294143014896 Autotransporter beta-domain; Region: Autotransporter; cl17461 1294143014897 SdiA-regulated; Region: SdiA-regulated; pfam06977 1294143014898 SdiA-regulated; Region: SdiA-regulated; cd09971 1294143014899 putative active site [active] 1294143014900 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143014901 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1294143014902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143014903 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1294143014904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143014905 Walker A/P-loop; other site 1294143014906 ATP binding site [chemical binding]; other site 1294143014907 Q-loop/lid; other site 1294143014908 ABC transporter signature motif; other site 1294143014909 Walker B; other site 1294143014910 D-loop; other site 1294143014911 H-loop/switch region; other site 1294143014912 TOBE domain; Region: TOBE_2; pfam08402 1294143014913 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1294143014914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014915 dimer interface [polypeptide binding]; other site 1294143014916 conserved gate region; other site 1294143014917 putative PBP binding loops; other site 1294143014918 ABC-ATPase subunit interface; other site 1294143014919 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1294143014920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014921 dimer interface [polypeptide binding]; other site 1294143014922 conserved gate region; other site 1294143014923 putative PBP binding loops; other site 1294143014924 ABC-ATPase subunit interface; other site 1294143014925 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143014926 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143014927 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1294143014928 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1294143014929 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1294143014930 active site 1294143014931 Zn binding site [ion binding]; other site 1294143014932 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1294143014933 SdiA-regulated; Region: SdiA-regulated; pfam06977 1294143014934 SdiA-regulated; Region: SdiA-regulated; cd09971 1294143014935 putative active site [active] 1294143014936 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1294143014937 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1294143014938 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1294143014939 FAD binding domain; Region: FAD_binding_4; pfam01565 1294143014940 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1294143014941 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1294143014942 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1294143014943 ligand binding site [chemical binding]; other site 1294143014944 NAD binding site [chemical binding]; other site 1294143014945 tetramer interface [polypeptide binding]; other site 1294143014946 catalytic site [active] 1294143014947 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1294143014948 L-serine binding site [chemical binding]; other site 1294143014949 ACT domain interface; other site 1294143014950 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1294143014951 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1294143014952 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1294143014953 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1294143014954 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1294143014955 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143014956 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143014957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143014958 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1294143014959 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1294143014960 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1294143014961 active site 1294143014962 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1294143014963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014964 dimer interface [polypeptide binding]; other site 1294143014965 conserved gate region; other site 1294143014966 putative PBP binding loops; other site 1294143014967 ABC-ATPase subunit interface; other site 1294143014968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143014969 dimer interface [polypeptide binding]; other site 1294143014970 conserved gate region; other site 1294143014971 putative PBP binding loops; other site 1294143014972 ABC-ATPase subunit interface; other site 1294143014973 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1294143014974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143014975 Walker A/P-loop; other site 1294143014976 ATP binding site [chemical binding]; other site 1294143014977 Q-loop/lid; other site 1294143014978 ABC transporter signature motif; other site 1294143014979 Walker B; other site 1294143014980 D-loop; other site 1294143014981 H-loop/switch region; other site 1294143014982 TOBE domain; Region: TOBE_2; pfam08402 1294143014983 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143014984 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143014985 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143014986 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143014987 putative aminotransferase; Validated; Region: PRK07480 1294143014988 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143014989 inhibitor-cofactor binding pocket; inhibition site 1294143014990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143014991 catalytic residue [active] 1294143014992 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1294143014993 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1294143014994 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1294143014995 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1294143014996 catalytic triad [active] 1294143014997 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1294143014998 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1294143014999 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1294143015000 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143015001 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143015002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143015003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143015004 agmatine deiminase; Provisional; Region: PRK13551 1294143015005 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1294143015006 outer membrane porin, OprD family; Region: OprD; pfam03573 1294143015007 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1294143015008 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1294143015009 SLBB domain; Region: SLBB; pfam10531 1294143015010 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1294143015011 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1294143015012 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1294143015013 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1294143015014 substrate binding site; other site 1294143015015 tetramer interface; other site 1294143015016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143015017 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1294143015018 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1294143015019 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1294143015020 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1294143015021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1294143015022 active site 1294143015023 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1294143015024 transcriptional activator RfaH; Region: RfaH; TIGR01955 1294143015025 WbqC-like protein family; Region: WbqC; pfam08889 1294143015026 tyrosine kinase; Provisional; Region: PRK11519 1294143015027 Chain length determinant protein; Region: Wzz; pfam02706 1294143015028 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1294143015029 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1294143015030 Nucleotide binding site [chemical binding]; other site 1294143015031 P loop; other site 1294143015032 DTAP/Switch II; other site 1294143015033 Switch I; other site 1294143015034 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1294143015035 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1294143015036 active site 1294143015037 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1294143015038 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1294143015039 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1294143015040 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1294143015041 inhibitor-cofactor binding pocket; inhibition site 1294143015042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143015043 catalytic residue [active] 1294143015044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1294143015045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143015046 PAS fold; Region: PAS_3; pfam08447 1294143015047 putative active site [active] 1294143015048 heme pocket [chemical binding]; other site 1294143015049 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143015050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143015051 metal binding site [ion binding]; metal-binding site 1294143015052 active site 1294143015053 I-site; other site 1294143015054 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1294143015055 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1294143015056 Di-iron ligands [ion binding]; other site 1294143015057 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1294143015058 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1294143015059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143015060 PAS fold; Region: PAS_3; pfam08447 1294143015061 putative active site [active] 1294143015062 heme pocket [chemical binding]; other site 1294143015063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143015064 PAS domain; Region: PAS_9; pfam13426 1294143015065 putative active site [active] 1294143015066 heme pocket [chemical binding]; other site 1294143015067 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143015068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143015069 metal binding site [ion binding]; metal-binding site 1294143015070 active site 1294143015071 I-site; other site 1294143015072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143015073 Uncharacterized small protein [Function unknown]; Region: COG5583 1294143015074 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1294143015075 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1294143015076 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1294143015077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143015078 dimer interface [polypeptide binding]; other site 1294143015079 conserved gate region; other site 1294143015080 putative PBP binding loops; other site 1294143015081 ABC-ATPase subunit interface; other site 1294143015082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143015083 dimer interface [polypeptide binding]; other site 1294143015084 conserved gate region; other site 1294143015085 putative PBP binding loops; other site 1294143015086 ABC-ATPase subunit interface; other site 1294143015087 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1294143015088 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1294143015089 Walker A/P-loop; other site 1294143015090 ATP binding site [chemical binding]; other site 1294143015091 Q-loop/lid; other site 1294143015092 ABC transporter signature motif; other site 1294143015093 Walker B; other site 1294143015094 D-loop; other site 1294143015095 H-loop/switch region; other site 1294143015096 TOBE-like domain; Region: TOBE_3; pfam12857 1294143015097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1294143015098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143015099 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1294143015100 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1294143015101 putative NAD(P) binding site [chemical binding]; other site 1294143015102 active site 1294143015103 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1294143015104 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1294143015105 putative catalytic residue [active] 1294143015106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1294143015107 sequence-specific DNA binding site [nucleotide binding]; other site 1294143015108 salt bridge; other site 1294143015109 Predicted membrane protein [Function unknown]; Region: COG4539 1294143015110 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1294143015111 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143015112 ligand binding site [chemical binding]; other site 1294143015113 flexible hinge region; other site 1294143015114 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1294143015115 non-specific DNA interactions [nucleotide binding]; other site 1294143015116 DNA binding site [nucleotide binding] 1294143015117 sequence specific DNA binding site [nucleotide binding]; other site 1294143015118 putative cAMP binding site [chemical binding]; other site 1294143015119 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1294143015120 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1294143015121 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1294143015122 Cl binding site [ion binding]; other site 1294143015123 oligomer interface [polypeptide binding]; other site 1294143015124 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1294143015125 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1294143015126 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1294143015127 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1294143015128 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1294143015129 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1294143015130 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1294143015131 frataxin-like protein; Provisional; Region: cyaY; PRK00446 1294143015132 putative iron binding site [ion binding]; other site 1294143015133 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143015134 Helix-turn-helix domain; Region: HTH_18; pfam12833 1294143015135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143015136 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1294143015137 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1294143015138 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1294143015139 active site 1294143015140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1294143015141 substrate binding site [chemical binding]; other site 1294143015142 catalytic residues [active] 1294143015143 dimer interface [polypeptide binding]; other site 1294143015144 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1294143015145 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1294143015146 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1294143015147 Protein of unknown function, DUF484; Region: DUF484; pfam04340 1294143015148 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1294143015149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1294143015150 active site 1294143015151 DNA binding site [nucleotide binding] 1294143015152 Int/Topo IB signature motif; other site 1294143015153 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1294143015154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1294143015155 motif II; other site 1294143015156 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1294143015157 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1294143015158 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1294143015159 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1294143015160 Membrane fusogenic activity; Region: BMFP; pfam04380 1294143015161 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1294143015162 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1294143015163 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1294143015164 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1294143015165 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1294143015166 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143015167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143015168 DNA-binding site [nucleotide binding]; DNA binding site 1294143015169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143015170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143015171 homodimer interface [polypeptide binding]; other site 1294143015172 catalytic residue [active] 1294143015173 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1294143015174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1294143015175 catalytic residues [active] 1294143015176 BCCT family transporter; Region: BCCT; cl00569 1294143015177 RHS protein; Region: RHS; pfam03527 1294143015178 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1294143015179 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1294143015180 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1294143015181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143015182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1294143015183 dimerization interface [polypeptide binding]; other site 1294143015184 multidrug efflux protein NorA; Provisional; Region: PRK00187 1294143015185 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1294143015186 cation binding site [ion binding]; other site 1294143015187 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143015188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143015189 metal binding site [ion binding]; metal-binding site 1294143015190 active site 1294143015191 I-site; other site 1294143015192 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143015193 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1294143015194 Part of AAA domain; Region: AAA_19; pfam13245 1294143015195 Family description; Region: UvrD_C_2; pfam13538 1294143015196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143015197 active site 1294143015198 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1294143015199 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1294143015200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143015201 non-specific DNA binding site [nucleotide binding]; other site 1294143015202 salt bridge; other site 1294143015203 sequence-specific DNA binding site [nucleotide binding]; other site 1294143015204 Cupin domain; Region: Cupin_2; pfam07883 1294143015205 alanine racemase; Reviewed; Region: dadX; PRK03646 1294143015206 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1294143015207 active site 1294143015208 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1294143015209 substrate binding site [chemical binding]; other site 1294143015210 catalytic residues [active] 1294143015211 dimer interface [polypeptide binding]; other site 1294143015212 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1294143015213 homotrimer interaction site [polypeptide binding]; other site 1294143015214 putative active site [active] 1294143015215 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1294143015216 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143015217 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1294143015218 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 1294143015219 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1294143015220 Dicarboxylate transport; Region: DctA-YdbH; cl14674 1294143015221 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 1294143015222 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1294143015223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1294143015224 putative DNA binding site [nucleotide binding]; other site 1294143015225 putative Zn2+ binding site [ion binding]; other site 1294143015226 AsnC family; Region: AsnC_trans_reg; pfam01037 1294143015227 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143015228 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1294143015229 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1294143015230 PLD-like domain; Region: PLDc_2; pfam13091 1294143015231 putative active site [active] 1294143015232 catalytic site [active] 1294143015233 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1294143015234 PLD-like domain; Region: PLDc_2; pfam13091 1294143015235 putative active site [active] 1294143015236 catalytic site [active] 1294143015237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143015238 putative substrate translocation pore; other site 1294143015239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1294143015240 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1294143015241 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1294143015242 NAD(P) binding site [chemical binding]; other site 1294143015243 catalytic residues [active] 1294143015244 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1294143015245 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1294143015246 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1294143015247 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1294143015248 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1294143015249 peptide binding site [polypeptide binding]; other site 1294143015250 hypothetical protein; Reviewed; Region: PRK00024 1294143015251 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1294143015252 MPN+ (JAMM) motif; other site 1294143015253 Zinc-binding site [ion binding]; other site 1294143015254 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1294143015255 Flavoprotein; Region: Flavoprotein; pfam02441 1294143015256 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1294143015257 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1294143015258 trimer interface [polypeptide binding]; other site 1294143015259 active site 1294143015260 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1294143015261 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1294143015262 active site 1294143015263 substrate binding site [chemical binding]; other site 1294143015264 metal binding site [ion binding]; metal-binding site 1294143015265 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1294143015266 feedback inhibition sensing region; other site 1294143015267 homohexameric interface [polypeptide binding]; other site 1294143015268 nucleotide binding site [chemical binding]; other site 1294143015269 N-acetyl-L-glutamate binding site [chemical binding]; other site 1294143015270 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1294143015271 active site 1294143015272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1294143015273 active site 1294143015274 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1294143015275 putative active site [active] 1294143015276 putative catalytic site [active] 1294143015277 putative DNA binding site [nucleotide binding]; other site 1294143015278 putative phosphate binding site [ion binding]; other site 1294143015279 metal binding site A [ion binding]; metal-binding site 1294143015280 putative AP binding site [nucleotide binding]; other site 1294143015281 putative metal binding site B [ion binding]; other site 1294143015282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1294143015283 ribonuclease PH; Reviewed; Region: rph; PRK00173 1294143015284 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1294143015285 hexamer interface [polypeptide binding]; other site 1294143015286 active site 1294143015287 hypothetical protein; Provisional; Region: PRK11820 1294143015288 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1294143015289 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1294143015290 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1294143015291 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1294143015292 catalytic site [active] 1294143015293 G-X2-G-X-G-K; other site 1294143015294 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1294143015295 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1294143015296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1294143015297 Zn2+ binding site [ion binding]; other site 1294143015298 Mg2+ binding site [ion binding]; other site 1294143015299 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1294143015300 synthetase active site [active] 1294143015301 NTP binding site [chemical binding]; other site 1294143015302 metal binding site [ion binding]; metal-binding site 1294143015303 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1294143015304 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1294143015305 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1294143015306 homotrimer interaction site [polypeptide binding]; other site 1294143015307 putative active site [active] 1294143015308 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1294143015309 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1294143015310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143015311 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1294143015312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143015313 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1294143015314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1294143015315 putative NAD(P) binding site [chemical binding]; other site 1294143015316 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1294143015317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143015318 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1294143015319 dimerization interface [polypeptide binding]; other site 1294143015320 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1294143015321 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1294143015322 ssDNA binding site; other site 1294143015323 generic binding surface II; other site 1294143015324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1294143015325 ATP binding site [chemical binding]; other site 1294143015326 putative Mg++ binding site [ion binding]; other site 1294143015327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1294143015328 nucleotide binding region [chemical binding]; other site 1294143015329 ATP-binding site [chemical binding]; other site 1294143015330 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1294143015331 putative deacylase active site [active] 1294143015332 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1294143015333 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1294143015334 IHF dimer interface [polypeptide binding]; other site 1294143015335 IHF - DNA interface [nucleotide binding]; other site 1294143015336 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1294143015337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1294143015338 Rubredoxin [Energy production and conversion]; Region: COG1773 1294143015339 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1294143015340 iron binding site [ion binding]; other site 1294143015341 Rubredoxin [Energy production and conversion]; Region: COG1773 1294143015342 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1294143015343 iron binding site [ion binding]; other site 1294143015344 Chorismate lyase; Region: Chor_lyase; cl01230 1294143015345 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1294143015346 UbiA prenyltransferase family; Region: UbiA; pfam01040 1294143015347 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1294143015348 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1294143015349 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1294143015350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143015351 active site 1294143015352 phosphorylation site [posttranslational modification] 1294143015353 intermolecular recognition site; other site 1294143015354 dimerization interface [polypeptide binding]; other site 1294143015355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143015356 DNA binding site [nucleotide binding] 1294143015357 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1294143015358 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1294143015359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143015360 putative active site [active] 1294143015361 heme pocket [chemical binding]; other site 1294143015362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143015363 dimer interface [polypeptide binding]; other site 1294143015364 phosphorylation site [posttranslational modification] 1294143015365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143015366 ATP binding site [chemical binding]; other site 1294143015367 Mg2+ binding site [ion binding]; other site 1294143015368 G-X-G motif; other site 1294143015369 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1294143015370 Domain of unknown function DUF21; Region: DUF21; pfam01595 1294143015371 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1294143015372 Transporter associated domain; Region: CorC_HlyC; smart01091 1294143015373 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1294143015374 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1294143015375 Peptidase family M23; Region: Peptidase_M23; pfam01551 1294143015376 Response regulator receiver domain; Region: Response_reg; pfam00072 1294143015377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143015378 active site 1294143015379 phosphorylation site [posttranslational modification] 1294143015380 intermolecular recognition site; other site 1294143015381 dimerization interface [polypeptide binding]; other site 1294143015382 transcriptional regulator PhoU; Provisional; Region: PRK11115 1294143015383 PhoU domain; Region: PhoU; pfam01895 1294143015384 PhoU domain; Region: PhoU; pfam01895 1294143015385 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1294143015386 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1294143015387 Walker A/P-loop; other site 1294143015388 ATP binding site [chemical binding]; other site 1294143015389 Q-loop/lid; other site 1294143015390 ABC transporter signature motif; other site 1294143015391 Walker B; other site 1294143015392 D-loop; other site 1294143015393 H-loop/switch region; other site 1294143015394 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1294143015395 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1294143015396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143015397 dimer interface [polypeptide binding]; other site 1294143015398 conserved gate region; other site 1294143015399 putative PBP binding loops; other site 1294143015400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1294143015401 ABC-ATPase subunit interface; other site 1294143015402 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1294143015403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143015404 ABC-ATPase subunit interface; other site 1294143015405 PBP superfamily domain; Region: PBP_like_2; cl17296 1294143015406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1294143015407 metabolite-proton symporter; Region: 2A0106; TIGR00883 1294143015408 putative substrate translocation pore; other site 1294143015409 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1294143015410 choline dehydrogenase; Validated; Region: PRK02106 1294143015411 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1294143015412 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1294143015413 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1294143015414 tetrameric interface [polypeptide binding]; other site 1294143015415 NAD binding site [chemical binding]; other site 1294143015416 catalytic residues [active] 1294143015417 transcriptional regulator BetI; Validated; Region: PRK00767 1294143015418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143015419 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1294143015420 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1294143015421 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1294143015422 Sulphur transport; Region: Sulf_transp; pfam04143 1294143015423 Predicted transporter component [General function prediction only]; Region: COG2391 1294143015424 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1294143015425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143015426 DNA-binding site [nucleotide binding]; DNA binding site 1294143015427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143015428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143015429 homodimer interface [polypeptide binding]; other site 1294143015430 catalytic residue [active] 1294143015431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1294143015432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1294143015433 Coenzyme A binding pocket [chemical binding]; other site 1294143015434 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1294143015435 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1294143015436 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1294143015437 active site 1294143015438 phosphate binding residues; other site 1294143015439 catalytic residues [active] 1294143015440 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1294143015441 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1294143015442 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1294143015443 ATP-grasp domain; Region: ATP-grasp; pfam02222 1294143015444 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1294143015445 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1294143015446 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1294143015447 NAD binding site [chemical binding]; other site 1294143015448 substrate binding site [chemical binding]; other site 1294143015449 catalytic Zn binding site [ion binding]; other site 1294143015450 tetramer interface [polypeptide binding]; other site 1294143015451 structural Zn binding site [ion binding]; other site 1294143015452 cell density-dependent motility repressor; Provisional; Region: PRK10082 1294143015453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143015454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1294143015455 dimerization interface [polypeptide binding]; other site 1294143015456 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1294143015457 Aspartase; Region: Aspartase; cd01357 1294143015458 active sites [active] 1294143015459 tetramer interface [polypeptide binding]; other site 1294143015460 Cell division protein ZapA; Region: ZapA; pfam05164 1294143015461 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1294143015462 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1294143015463 Ligand Binding Site [chemical binding]; other site 1294143015464 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1294143015465 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1294143015466 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1294143015467 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1294143015468 Cysteine-rich domain; Region: CCG; pfam02754 1294143015469 Cysteine-rich domain; Region: CCG; pfam02754 1294143015470 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1294143015471 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1294143015472 putative active site [active] 1294143015473 putative FMN binding site [chemical binding]; other site 1294143015474 putative substrate binding site [chemical binding]; other site 1294143015475 putative catalytic residue [active] 1294143015476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1294143015477 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1294143015478 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1294143015479 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1294143015480 active site 1294143015481 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1294143015482 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1294143015483 [2Fe-2S] cluster binding site [ion binding]; other site 1294143015484 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1294143015485 putative alpha subunit interface [polypeptide binding]; other site 1294143015486 putative active site [active] 1294143015487 putative substrate binding site [chemical binding]; other site 1294143015488 Fe binding site [ion binding]; other site 1294143015489 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1294143015490 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1294143015491 FAD binding pocket [chemical binding]; other site 1294143015492 FAD binding motif [chemical binding]; other site 1294143015493 phosphate binding motif [ion binding]; other site 1294143015494 beta-alpha-beta structure motif; other site 1294143015495 NAD binding pocket [chemical binding]; other site 1294143015496 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1294143015497 catalytic loop [active] 1294143015498 iron binding site [ion binding]; other site 1294143015499 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1294143015500 elongation factor G; Reviewed; Region: PRK12740 1294143015501 G1 box; other site 1294143015502 putative GEF interaction site [polypeptide binding]; other site 1294143015503 GTP/Mg2+ binding site [chemical binding]; other site 1294143015504 Switch I region; other site 1294143015505 G2 box; other site 1294143015506 G3 box; other site 1294143015507 Switch II region; other site 1294143015508 G4 box; other site 1294143015509 G5 box; other site 1294143015510 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1294143015511 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1294143015512 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1294143015513 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1294143015514 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1294143015515 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1294143015516 tetramer interface [polypeptide binding]; other site 1294143015517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143015518 catalytic residue [active] 1294143015519 Uncharacterized conserved protein [Function unknown]; Region: COG4104 1294143015520 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1294143015521 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1294143015522 dimer interface [polypeptide binding]; other site 1294143015523 active site 1294143015524 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1294143015525 folate binding site [chemical binding]; other site 1294143015526 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1294143015527 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1294143015528 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1294143015529 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1294143015530 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1294143015531 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1294143015532 sarcosine oxidase, gamma subunit family, heterotetrameric form; Region: soxG; TIGR01375 1294143015533 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1294143015534 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1294143015535 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1294143015536 putative active site [active] 1294143015537 putative substrate binding site [chemical binding]; other site 1294143015538 putative cosubstrate binding site; other site 1294143015539 catalytic site [active] 1294143015540 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1294143015541 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1294143015542 NAD binding site [chemical binding]; other site 1294143015543 catalytic Zn binding site [ion binding]; other site 1294143015544 structural Zn binding site [ion binding]; other site 1294143015545 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1294143015546 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1294143015547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1294143015548 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1294143015549 acyl-activating enzyme (AAE) consensus motif; other site 1294143015550 putative AMP binding site [chemical binding]; other site 1294143015551 putative active site [active] 1294143015552 putative CoA binding site [chemical binding]; other site 1294143015553 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1294143015554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143015555 active site 1294143015556 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1294143015557 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1294143015558 active site 1294143015559 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1294143015560 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1294143015561 active site 1294143015562 Zn binding site [ion binding]; other site 1294143015563 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1294143015564 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1294143015565 Na binding site [ion binding]; other site 1294143015566 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1294143015567 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1294143015568 putative aminotransferase; Provisional; Region: PRK12403 1294143015569 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143015570 inhibitor-cofactor binding pocket; inhibition site 1294143015571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143015572 catalytic residue [active] 1294143015573 amino acid transporter; Region: 2A0306; TIGR00909 1294143015574 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1294143015575 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1294143015576 NAD(P) binding site [chemical binding]; other site 1294143015577 catalytic residues [active] 1294143015578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143015579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143015580 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1294143015581 putative substrate binding pocket [chemical binding]; other site 1294143015582 dimerization interface [polypeptide binding]; other site 1294143015583 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1294143015584 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1294143015585 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1294143015586 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1294143015587 PhnA protein; Region: PhnA; pfam03831 1294143015588 Cytochrome c; Region: Cytochrom_C; cl11414 1294143015589 Cytochrome c; Region: Cytochrom_C; cl11414 1294143015590 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1294143015591 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1294143015592 active site 1294143015593 catalytic residues [active] 1294143015594 metal binding site [ion binding]; metal-binding site 1294143015595 homodimer binding site [polypeptide binding]; other site 1294143015596 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1294143015597 carboxyltransferase (CT) interaction site; other site 1294143015598 biotinylation site [posttranslational modification]; other site 1294143015599 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1294143015600 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1294143015601 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1294143015602 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1294143015603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143015604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143015605 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1294143015606 putative dimerization interface [polypeptide binding]; other site 1294143015607 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1294143015608 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1294143015609 putative active site [active] 1294143015610 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1294143015611 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1294143015612 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1294143015613 putative protease; Provisional; Region: PRK15452 1294143015614 Peptidase family U32; Region: Peptidase_U32; pfam01136 1294143015615 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1294143015616 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1294143015617 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1294143015618 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1294143015619 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1294143015620 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1294143015621 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1294143015622 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143015623 ligand binding site [chemical binding]; other site 1294143015624 flexible hinge region; other site 1294143015625 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1294143015626 putative switch regulator; other site 1294143015627 non-specific DNA interactions [nucleotide binding]; other site 1294143015628 DNA binding site [nucleotide binding] 1294143015629 sequence specific DNA binding site [nucleotide binding]; other site 1294143015630 putative cAMP binding site [chemical binding]; other site 1294143015631 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1294143015632 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1294143015633 Hemerythrin-like domain; Region: Hr-like; cd12108 1294143015634 Fe binding site [ion binding]; other site 1294143015635 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1294143015636 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1294143015637 ligand binding site [chemical binding]; other site 1294143015638 flexible hinge region; other site 1294143015639 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1294143015640 putative switch regulator; other site 1294143015641 non-specific DNA interactions [nucleotide binding]; other site 1294143015642 DNA binding site [nucleotide binding] 1294143015643 sequence specific DNA binding site [nucleotide binding]; other site 1294143015644 putative cAMP binding site [chemical binding]; other site 1294143015645 Bacitracin resistance protein BacA; Region: BacA; cl00858 1294143015646 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1294143015647 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1294143015648 metal ion-dependent adhesion site (MIDAS); other site 1294143015649 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1294143015650 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1294143015651 Low-spin heme binding site [chemical binding]; other site 1294143015652 D-pathway; other site 1294143015653 Binuclear center (active site) [active] 1294143015654 K-pathway; other site 1294143015655 Putative proton exit pathway; other site 1294143015656 Putative water exit pathway; other site 1294143015657 Cytochrome c; Region: Cytochrom_C; pfam00034 1294143015658 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1294143015659 Subunit I/III interface [polypeptide binding]; other site 1294143015660 MoxR-like ATPases [General function prediction only]; Region: COG0714 1294143015661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143015662 Walker A motif; other site 1294143015663 ATP binding site [chemical binding]; other site 1294143015664 Walker B motif; other site 1294143015665 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1294143015666 Cytochrome c; Region: Cytochrom_C; cl11414 1294143015667 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1294143015668 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1294143015669 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1294143015670 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1294143015671 nitrous-oxide reductase; Validated; Region: PRK02888 1294143015672 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1294143015673 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 1294143015674 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1294143015675 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1294143015676 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1294143015677 Walker A/P-loop; other site 1294143015678 ATP binding site [chemical binding]; other site 1294143015679 Q-loop/lid; other site 1294143015680 ABC transporter signature motif; other site 1294143015681 Walker B; other site 1294143015682 D-loop; other site 1294143015683 H-loop/switch region; other site 1294143015684 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1294143015685 NosL; Region: NosL; pfam05573 1294143015686 PAS fold; Region: PAS_3; pfam08447 1294143015687 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1294143015688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143015689 PAS domain; Region: PAS_9; pfam13426 1294143015690 putative active site [active] 1294143015691 heme pocket [chemical binding]; other site 1294143015692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1294143015693 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1294143015694 metal binding site [ion binding]; metal-binding site 1294143015695 active site 1294143015696 I-site; other site 1294143015697 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1294143015698 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1294143015699 Part of AAA domain; Region: AAA_19; pfam13245 1294143015700 Family description; Region: UvrD_C_2; pfam13538 1294143015701 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1294143015702 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1294143015703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1294143015704 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1294143015705 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1294143015706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1294143015707 DNA-binding site [nucleotide binding]; DNA binding site 1294143015708 FCD domain; Region: FCD; pfam07729 1294143015709 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1294143015710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1294143015711 NAD(P) binding site [chemical binding]; other site 1294143015712 active site 1294143015713 aminotransferase; Validated; Region: PRK07046 1294143015714 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143015715 inhibitor-cofactor binding pocket; inhibition site 1294143015716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143015717 catalytic residue [active] 1294143015718 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1294143015719 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1294143015720 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1294143015721 classical (c) SDRs; Region: SDR_c; cd05233 1294143015722 NAD(P) binding site [chemical binding]; other site 1294143015723 active site 1294143015724 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1294143015725 putative cation:proton antiport protein; Provisional; Region: PRK10669 1294143015726 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1294143015727 TrkA-N domain; Region: TrkA_N; pfam02254 1294143015728 pyridoxamine kinase; Validated; Region: PRK05756 1294143015729 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1294143015730 pyridoxal binding site [chemical binding]; other site 1294143015731 dimer interface [polypeptide binding]; other site 1294143015732 ATP binding site [chemical binding]; other site 1294143015733 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1294143015734 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1294143015735 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1294143015736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143015737 dimer interface [polypeptide binding]; other site 1294143015738 phosphorylation site [posttranslational modification] 1294143015739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143015740 ATP binding site [chemical binding]; other site 1294143015741 G-X-G motif; other site 1294143015742 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1294143015743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143015744 active site 1294143015745 phosphorylation site [posttranslational modification] 1294143015746 intermolecular recognition site; other site 1294143015747 dimerization interface [polypeptide binding]; other site 1294143015748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143015749 Walker A motif; other site 1294143015750 ATP binding site [chemical binding]; other site 1294143015751 Walker B motif; other site 1294143015752 arginine finger; other site 1294143015753 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143015754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1294143015755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1294143015756 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1294143015757 putative effector binding pocket; other site 1294143015758 dimerization interface [polypeptide binding]; other site 1294143015759 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1294143015760 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1294143015761 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1294143015762 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1294143015763 NAD binding site [chemical binding]; other site 1294143015764 catalytic residues [active] 1294143015765 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1294143015766 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1294143015767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143015768 homodimer interface [polypeptide binding]; other site 1294143015769 catalytic residue [active] 1294143015770 hypothetical protein; Provisional; Region: PRK07524 1294143015771 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1294143015772 PYR/PP interface [polypeptide binding]; other site 1294143015773 dimer interface [polypeptide binding]; other site 1294143015774 TPP binding site [chemical binding]; other site 1294143015775 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1294143015776 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1294143015777 TPP-binding site [chemical binding]; other site 1294143015778 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1294143015779 CoA binding domain; Region: CoA_binding_2; pfam13380 1294143015780 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1294143015781 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1294143015782 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1294143015783 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1294143015784 active site 1294143015785 enoyl-CoA hydratase; Provisional; Region: PRK06688 1294143015786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1294143015787 substrate binding site [chemical binding]; other site 1294143015788 oxyanion hole (OAH) forming residues; other site 1294143015789 trimer interface [polypeptide binding]; other site 1294143015790 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1294143015791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143015792 sequence-specific DNA binding site [nucleotide binding]; other site 1294143015793 salt bridge; other site 1294143015794 Cupin domain; Region: Cupin_2; pfam07883 1294143015795 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1294143015796 intersubunit interface [polypeptide binding]; other site 1294143015797 active site 1294143015798 Zn2+ binding site [ion binding]; other site 1294143015799 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1294143015800 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1294143015801 inhibitor site; inhibition site 1294143015802 active site 1294143015803 dimer interface [polypeptide binding]; other site 1294143015804 catalytic residue [active] 1294143015805 S-methylmethionine transporter; Provisional; Region: PRK11387 1294143015806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143015807 dimer interface [polypeptide binding]; other site 1294143015808 phosphorylation site [posttranslational modification] 1294143015809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143015810 ATP binding site [chemical binding]; other site 1294143015811 Mg2+ binding site [ion binding]; other site 1294143015812 G-X-G motif; other site 1294143015813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143015814 active site 1294143015815 phosphorylation site [posttranslational modification] 1294143015816 intermolecular recognition site; other site 1294143015817 dimerization interface [polypeptide binding]; other site 1294143015818 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1294143015819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1294143015820 substrate binding pocket [chemical binding]; other site 1294143015821 membrane-bound complex binding site; other site 1294143015822 hinge residues; other site 1294143015823 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1294143015824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143015825 active site 1294143015826 phosphorylation site [posttranslational modification] 1294143015827 intermolecular recognition site; other site 1294143015828 dimerization interface [polypeptide binding]; other site 1294143015829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1294143015830 DNA binding site [nucleotide binding] 1294143015831 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1294143015832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1294143015833 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1294143015834 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1294143015835 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1294143015836 hypothetical protein; Provisional; Region: PRK07036 1294143015837 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1294143015838 inhibitor-cofactor binding pocket; inhibition site 1294143015839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1294143015840 catalytic residue [active] 1294143015841 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1294143015842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1294143015843 DNA binding residues [nucleotide binding] 1294143015844 dimerization interface [polypeptide binding]; other site 1294143015845 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1294143015846 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1294143015847 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1294143015848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1294143015849 Walker A/P-loop; other site 1294143015850 ATP binding site [chemical binding]; other site 1294143015851 Q-loop/lid; other site 1294143015852 ABC transporter signature motif; other site 1294143015853 Walker B; other site 1294143015854 D-loop; other site 1294143015855 H-loop/switch region; other site 1294143015856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1294143015857 dimer interface [polypeptide binding]; other site 1294143015858 conserved gate region; other site 1294143015859 putative PBP binding loops; other site 1294143015860 ABC-ATPase subunit interface; other site 1294143015861 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1294143015862 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1294143015863 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1294143015864 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1294143015865 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1294143015866 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143015867 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1294143015868 conserved cys residue [active] 1294143015869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143015870 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1294143015871 dimer interface [polypeptide binding]; other site 1294143015872 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1294143015873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1294143015874 non-specific DNA binding site [nucleotide binding]; other site 1294143015875 sequence-specific DNA binding site [nucleotide binding]; other site 1294143015876 salt bridge; other site 1294143015877 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1294143015878 Transposase domain (DUF772); Region: DUF772; pfam05598 1294143015879 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1294143015880 DDE superfamily endonuclease; Region: DDE_4; cl17710 1294143015881 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1294143015882 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1294143015883 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1294143015884 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1294143015885 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1294143015886 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1294143015887 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1294143015888 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1294143015889 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1294143015890 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1294143015891 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1294143015892 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1294143015893 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1294143015894 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1294143015895 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1294143015896 active site 1294143015897 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1294143015898 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1294143015899 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1294143015900 Uncharacterized conserved protein [Function unknown]; Region: COG3246 1294143015901 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1294143015902 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1294143015903 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1294143015904 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1294143015905 conserved cys residue [active] 1294143015906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143015907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1294143015908 SnoaL-like domain; Region: SnoaL_2; pfam12680 1294143015909 Predicted permeases [General function prediction only]; Region: COG0679 1294143015910 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1294143015911 Citrate transporter; Region: CitMHS; pfam03600 1294143015912 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1294143015913 Water Stress and Hypersensitive response; Region: WHy; smart00769 1294143015914 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1294143015915 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1294143015916 PhoU domain; Region: PhoU; pfam01895 1294143015917 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1294143015918 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1294143015919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1294143015920 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1294143015921 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1294143015922 putative NAD(P) binding site [chemical binding]; other site 1294143015923 active site 1294143015924 putative substrate binding site [chemical binding]; other site 1294143015925 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1294143015926 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1294143015927 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1294143015928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 1294143015929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1294143015930 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 1294143015931 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1294143015932 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1294143015933 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1294143015934 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1294143015935 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1294143015936 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 1294143015937 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1294143015938 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1294143015939 BON domain; Region: BON; pfam04972 1294143015940 BON domain; Region: BON; pfam04972 1294143015941 BON domain; Region: BON; pfam04972 1294143015942 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1294143015943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1294143015944 active site 1294143015945 phosphorylation site [posttranslational modification] 1294143015946 intermolecular recognition site; other site 1294143015947 dimerization interface [polypeptide binding]; other site 1294143015948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1294143015949 Walker A motif; other site 1294143015950 ATP binding site [chemical binding]; other site 1294143015951 Walker B motif; other site 1294143015952 arginine finger; other site 1294143015953 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1294143015954 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1294143015955 dimerization interface [polypeptide binding]; other site 1294143015956 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1294143015957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1294143015958 putative active site [active] 1294143015959 heme pocket [chemical binding]; other site 1294143015960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1294143015961 dimer interface [polypeptide binding]; other site 1294143015962 phosphorylation site [posttranslational modification] 1294143015963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1294143015964 ATP binding site [chemical binding]; other site 1294143015965 Mg2+ binding site [ion binding]; other site 1294143015966 G-X-G motif; other site 1294143015967 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1294143015968 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1294143015969 amidase catalytic site [active] 1294143015970 Zn binding residues [ion binding]; other site 1294143015971 substrate binding site [chemical binding]; other site 1294143015972 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1294143015973 MarC family integral membrane protein; Region: MarC; cl00919 1294143015974 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1294143015975 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1294143015976 Substrate binding site; other site 1294143015977 Mg++ binding site; other site 1294143015978 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1294143015979 active site 1294143015980 substrate binding site [chemical binding]; other site 1294143015981 CoA binding site [chemical binding]; other site 1294143015982 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1294143015983 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1294143015984 gamma subunit interface [polypeptide binding]; other site 1294143015985 epsilon subunit interface [polypeptide binding]; other site 1294143015986 LBP interface [polypeptide binding]; other site 1294143015987 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1294143015988 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1294143015989 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1294143015990 alpha subunit interaction interface [polypeptide binding]; other site 1294143015991 Walker A motif; other site 1294143015992 ATP binding site [chemical binding]; other site 1294143015993 Walker B motif; other site 1294143015994 inhibitor binding site; inhibition site 1294143015995 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1294143015996 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1294143015997 core domain interface [polypeptide binding]; other site 1294143015998 delta subunit interface [polypeptide binding]; other site 1294143015999 epsilon subunit interface [polypeptide binding]; other site 1294143016000 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1294143016001 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1294143016002 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1294143016003 beta subunit interaction interface [polypeptide binding]; other site 1294143016004 Walker A motif; other site 1294143016005 ATP binding site [chemical binding]; other site 1294143016006 Walker B motif; other site 1294143016007 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1294143016008 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1294143016009 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1294143016010 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1294143016011 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1294143016012 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1294143016013 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1294143016014 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1294143016015 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1294143016016 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1294143016017 ParB-like nuclease domain; Region: ParBc; pfam02195 1294143016018 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1294143016019 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1294143016020 P-loop; other site 1294143016021 Magnesium ion binding site [ion binding]; other site 1294143016022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1294143016023 Magnesium ion binding site [ion binding]; other site 1294143016024 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1294143016025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1294143016026 S-adenosylmethionine binding site [chemical binding]; other site 1294143016027 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1294143016028 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1294143016029 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1294143016030 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1294143016031 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1294143016032 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1294143016033 G1 box; other site 1294143016034 GTP/Mg2+ binding site [chemical binding]; other site 1294143016035 Switch I region; other site 1294143016036 G2 box; other site 1294143016037 Switch II region; other site 1294143016038 G3 box; other site 1294143016039 G4 box; other site 1294143016040 G5 box; other site 1294143016041 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1294143016042 membrane protein insertase; Provisional; Region: PRK01318 1294143016043 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1294143016044 Haemolytic domain; Region: Haemolytic; pfam01809 1294143016045 ribonuclease P; Reviewed; Region: rnpA; PRK00396 1294143016046 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399