-- dump date 20140620_005011 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1037911000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1037911000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1037911000004 Walker A motif; other site 1037911000005 ATP binding site [chemical binding]; other site 1037911000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1037911000007 Walker B motif; other site 1037911000008 arginine finger; other site 1037911000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1037911000010 DnaA box-binding interface [nucleotide binding]; other site 1037911000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1037911000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1037911000013 putative DNA binding surface [nucleotide binding]; other site 1037911000014 dimer interface [polypeptide binding]; other site 1037911000015 beta-clamp/clamp loader binding surface; other site 1037911000016 beta-clamp/translesion DNA polymerase binding surface; other site 1037911000017 recombination protein F; Reviewed; Region: recF; PRK00064 1037911000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911000019 Walker A/P-loop; other site 1037911000020 ATP binding site [chemical binding]; other site 1037911000021 Q-loop/lid; other site 1037911000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911000023 ABC transporter signature motif; other site 1037911000024 Walker B; other site 1037911000025 D-loop; other site 1037911000026 H-loop/switch region; other site 1037911000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1037911000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911000029 Mg2+ binding site [ion binding]; other site 1037911000030 G-X-G motif; other site 1037911000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1037911000032 anchoring element; other site 1037911000033 dimer interface [polypeptide binding]; other site 1037911000034 ATP binding site [chemical binding]; other site 1037911000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1037911000036 active site 1037911000037 putative metal-binding site [ion binding]; other site 1037911000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1037911000039 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911000040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911000041 active site 1037911000042 phosphorylation site [posttranslational modification] 1037911000043 intermolecular recognition site; other site 1037911000044 dimerization interface [polypeptide binding]; other site 1037911000045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911000046 DNA binding site [nucleotide binding] 1037911000047 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1037911000048 CHASE2 domain; Region: CHASE2; pfam05226 1037911000049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911000050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911000051 dimer interface [polypeptide binding]; other site 1037911000052 phosphorylation site [posttranslational modification] 1037911000053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911000054 ATP binding site [chemical binding]; other site 1037911000055 Mg2+ binding site [ion binding]; other site 1037911000056 G-X-G motif; other site 1037911000057 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1037911000058 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1037911000059 putative acyl-acceptor binding pocket; other site 1037911000060 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1037911000061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911000062 active site 1037911000063 motif I; other site 1037911000064 motif II; other site 1037911000065 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1037911000066 HD domain; Region: HD; pfam01966 1037911000067 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1037911000068 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1037911000069 dimer interface [polypeptide binding]; other site 1037911000070 motif 1; other site 1037911000071 active site 1037911000072 motif 2; other site 1037911000073 motif 3; other site 1037911000074 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1037911000075 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1037911000076 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1037911000077 putative acyl-acceptor binding pocket; other site 1037911000078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1037911000079 TPR motif; other site 1037911000080 binding surface 1037911000081 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1037911000082 TrkA-N domain; Region: TrkA_N; pfam02254 1037911000083 TrkA-C domain; Region: TrkA_C; pfam02080 1037911000084 TrkA-N domain; Region: TrkA_N; pfam02254 1037911000085 TrkA-C domain; Region: TrkA_C; pfam02080 1037911000086 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1037911000087 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1037911000088 putative RNA binding site [nucleotide binding]; other site 1037911000089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911000090 S-adenosylmethionine binding site [chemical binding]; other site 1037911000091 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1037911000092 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1037911000093 putative active site [active] 1037911000094 substrate binding site [chemical binding]; other site 1037911000095 putative cosubstrate binding site; other site 1037911000096 catalytic site [active] 1037911000097 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1037911000098 substrate binding site [chemical binding]; other site 1037911000099 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1037911000100 active site 1037911000101 catalytic residues [active] 1037911000102 metal binding site [ion binding]; metal-binding site 1037911000103 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1037911000104 DNA protecting protein DprA; Region: dprA; TIGR00732 1037911000105 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1037911000106 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1037911000107 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1037911000108 NADP binding site [chemical binding]; other site 1037911000109 dimer interface [polypeptide binding]; other site 1037911000110 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1037911000111 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1037911000112 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1037911000113 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1037911000114 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1037911000115 shikimate binding site; other site 1037911000116 NAD(P) binding site [chemical binding]; other site 1037911000117 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1037911000118 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1037911000119 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1037911000120 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1037911000121 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1037911000122 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1037911000123 Sulfatase; Region: Sulfatase; cl17466 1037911000124 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1037911000125 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1037911000126 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1037911000127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911000128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911000129 dimerization interface [polypeptide binding]; other site 1037911000130 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1037911000131 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1037911000132 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1037911000133 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1037911000134 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1037911000135 active site 1037911000136 intersubunit interface [polypeptide binding]; other site 1037911000137 catalytic residue [active] 1037911000138 galactonate dehydratase; Provisional; Region: PRK14017 1037911000139 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1037911000140 putative active site pocket [active] 1037911000141 putative metal binding site [ion binding]; other site 1037911000142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911000143 D-galactonate transporter; Region: 2A0114; TIGR00893 1037911000144 putative substrate translocation pore; other site 1037911000145 Berberine and berberine like; Region: BBE; pfam08031 1037911000146 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1037911000147 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1037911000148 substrate binding site [chemical binding]; other site 1037911000149 active site 1037911000150 catalytic residues [active] 1037911000151 heterodimer interface [polypeptide binding]; other site 1037911000152 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1037911000153 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1037911000154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911000155 catalytic residue [active] 1037911000156 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1037911000157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911000158 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 1037911000159 putative dimerization interface [polypeptide binding]; other site 1037911000160 putative substrate binding pocket [chemical binding]; other site 1037911000161 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1037911000162 Dodecin; Region: Dodecin; pfam07311 1037911000163 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1037911000164 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1037911000165 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1037911000166 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1037911000167 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1037911000168 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 1037911000169 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1037911000170 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1037911000171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911000172 motif II; other site 1037911000173 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1037911000174 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1037911000175 trimer interface [polypeptide binding]; other site 1037911000176 putative metal binding site [ion binding]; other site 1037911000177 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1037911000178 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1037911000179 active site 1037911000180 Zn binding site [ion binding]; other site 1037911000181 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1037911000182 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 1037911000183 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1037911000184 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1037911000185 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1037911000186 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911000187 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911000188 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1037911000189 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1037911000190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911000191 FeS/SAM binding site; other site 1037911000192 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1037911000193 active site clefts [active] 1037911000194 zinc binding site [ion binding]; other site 1037911000195 dimer interface [polypeptide binding]; other site 1037911000196 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1037911000197 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1037911000198 STAS domain; Region: STAS_2; pfam13466 1037911000199 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1037911000200 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1037911000201 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1037911000202 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911000203 Cytochrome c; Region: Cytochrom_C; pfam00034 1037911000204 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1037911000205 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1037911000206 Subunit I/III interface [polypeptide binding]; other site 1037911000207 D-pathway; other site 1037911000208 Subunit I/VIIc interface [polypeptide binding]; other site 1037911000209 Subunit I/IV interface [polypeptide binding]; other site 1037911000210 Subunit I/II interface [polypeptide binding]; other site 1037911000211 Low-spin heme (heme a) binding site [chemical binding]; other site 1037911000212 Subunit I/VIIa interface [polypeptide binding]; other site 1037911000213 Subunit I/VIa interface [polypeptide binding]; other site 1037911000214 Dimer interface; other site 1037911000215 Putative water exit pathway; other site 1037911000216 Binuclear center (heme a3/CuB) [ion binding]; other site 1037911000217 K-pathway; other site 1037911000218 Subunit I/Vb interface [polypeptide binding]; other site 1037911000219 Putative proton exit pathway; other site 1037911000220 Subunit I/VIb interface; other site 1037911000221 Subunit I/VIc interface [polypeptide binding]; other site 1037911000222 Electron transfer pathway; other site 1037911000223 Subunit I/VIIIb interface [polypeptide binding]; other site 1037911000224 Subunit I/VIIb interface [polypeptide binding]; other site 1037911000225 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1037911000226 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1037911000227 Subunit III/VIIa interface [polypeptide binding]; other site 1037911000228 Phospholipid binding site [chemical binding]; other site 1037911000229 Subunit I/III interface [polypeptide binding]; other site 1037911000230 Subunit III/VIb interface [polypeptide binding]; other site 1037911000231 Subunit III/VIa interface; other site 1037911000232 Subunit III/Vb interface [polypeptide binding]; other site 1037911000233 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1037911000234 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1037911000235 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1037911000236 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1037911000237 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1037911000238 UbiA prenyltransferase family; Region: UbiA; pfam01040 1037911000239 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1037911000240 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1037911000241 Cu(I) binding site [ion binding]; other site 1037911000242 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1037911000243 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1037911000244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000245 dimer interface [polypeptide binding]; other site 1037911000246 conserved gate region; other site 1037911000247 ABC-ATPase subunit interface; other site 1037911000248 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1037911000249 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1037911000250 Walker A/P-loop; other site 1037911000251 ATP binding site [chemical binding]; other site 1037911000252 Q-loop/lid; other site 1037911000253 ABC transporter signature motif; other site 1037911000254 Walker B; other site 1037911000255 D-loop; other site 1037911000256 H-loop/switch region; other site 1037911000257 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1037911000258 hydroperoxidase II; Provisional; Region: katE; PRK11249 1037911000259 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1037911000260 tetramer interface [polypeptide binding]; other site 1037911000261 heme binding pocket [chemical binding]; other site 1037911000262 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1037911000263 domain interactions; other site 1037911000264 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1037911000265 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1037911000266 ABC-ATPase subunit interface; other site 1037911000267 dimer interface [polypeptide binding]; other site 1037911000268 putative PBP binding regions; other site 1037911000269 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1037911000270 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1037911000271 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1037911000272 metal binding site 2 [ion binding]; metal-binding site 1037911000273 putative DNA binding helix; other site 1037911000274 metal binding site 1 [ion binding]; metal-binding site 1037911000275 dimer interface [polypeptide binding]; other site 1037911000276 structural Zn2+ binding site [ion binding]; other site 1037911000277 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1037911000278 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1037911000279 metal binding site [ion binding]; metal-binding site 1037911000280 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1037911000281 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1037911000282 putative active site [active] 1037911000283 putative substrate binding site [chemical binding]; other site 1037911000284 ATP binding site [chemical binding]; other site 1037911000285 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1037911000286 DNA polymerase I; Provisional; Region: PRK05755 1037911000287 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1037911000288 active site 1037911000289 metal binding site 1 [ion binding]; metal-binding site 1037911000290 putative 5' ssDNA interaction site; other site 1037911000291 metal binding site 3; metal-binding site 1037911000292 metal binding site 2 [ion binding]; metal-binding site 1037911000293 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1037911000294 putative DNA binding site [nucleotide binding]; other site 1037911000295 putative metal binding site [ion binding]; other site 1037911000296 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1037911000297 active site 1037911000298 catalytic site [active] 1037911000299 substrate binding site [chemical binding]; other site 1037911000300 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1037911000301 active site 1037911000302 DNA binding site [nucleotide binding] 1037911000303 catalytic site [active] 1037911000304 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1037911000305 G1 box; other site 1037911000306 GTP/Mg2+ binding site [chemical binding]; other site 1037911000307 Switch I region; other site 1037911000308 G2 box; other site 1037911000309 G3 box; other site 1037911000310 Switch II region; other site 1037911000311 G4 box; other site 1037911000312 G5 box; other site 1037911000313 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1037911000314 Cytochrome c; Region: Cytochrom_C; cl11414 1037911000315 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1037911000316 catalytic residues [active] 1037911000317 hinge region; other site 1037911000318 alpha helical domain; other site 1037911000319 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1037911000320 putative catalytic site [active] 1037911000321 putative metal binding site [ion binding]; other site 1037911000322 putative phosphate binding site [ion binding]; other site 1037911000323 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911000324 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911000325 metal binding site [ion binding]; metal-binding site 1037911000326 active site 1037911000327 I-site; other site 1037911000328 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1037911000329 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1037911000330 amidase catalytic site [active] 1037911000331 Zn binding residues [ion binding]; other site 1037911000332 substrate binding site [chemical binding]; other site 1037911000333 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1037911000334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911000335 dimerization interface [polypeptide binding]; other site 1037911000336 PAS domain; Region: PAS; smart00091 1037911000337 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1037911000338 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911000339 dimer interface [polypeptide binding]; other site 1037911000340 phosphorylation site [posttranslational modification] 1037911000341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911000342 ATP binding site [chemical binding]; other site 1037911000343 Mg2+ binding site [ion binding]; other site 1037911000344 G-X-G motif; other site 1037911000345 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911000346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911000347 active site 1037911000348 phosphorylation site [posttranslational modification] 1037911000349 intermolecular recognition site; other site 1037911000350 dimerization interface [polypeptide binding]; other site 1037911000351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911000352 Walker A motif; other site 1037911000353 ATP binding site [chemical binding]; other site 1037911000354 Walker B motif; other site 1037911000355 arginine finger; other site 1037911000356 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911000357 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 1037911000358 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1037911000359 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1037911000360 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1037911000361 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1037911000362 Protein of unknown function (DUF330); Region: DUF330; cl01135 1037911000363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1037911000364 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1037911000365 mce related protein; Region: MCE; pfam02470 1037911000366 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1037911000367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911000368 Walker A/P-loop; other site 1037911000369 ATP binding site [chemical binding]; other site 1037911000370 Q-loop/lid; other site 1037911000371 ABC transporter signature motif; other site 1037911000372 Walker B; other site 1037911000373 D-loop; other site 1037911000374 H-loop/switch region; other site 1037911000375 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1037911000376 Permease; Region: Permease; pfam02405 1037911000377 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1037911000378 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1037911000379 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1037911000380 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1037911000381 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1037911000382 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1037911000383 PhoU domain; Region: PhoU; pfam01895 1037911000384 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1037911000385 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1037911000386 Citrate transporter; Region: CitMHS; pfam03600 1037911000387 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1037911000388 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1037911000389 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1037911000390 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1037911000391 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1037911000392 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1037911000393 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1037911000394 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1037911000395 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1037911000396 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1037911000397 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1037911000398 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1037911000399 ligand binding site [chemical binding]; other site 1037911000400 homodimer interface [polypeptide binding]; other site 1037911000401 NAD(P) binding site [chemical binding]; other site 1037911000402 trimer interface B [polypeptide binding]; other site 1037911000403 trimer interface A [polypeptide binding]; other site 1037911000404 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1037911000405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911000406 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1037911000407 dimerization interface [polypeptide binding]; other site 1037911000408 substrate binding pocket [chemical binding]; other site 1037911000409 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1037911000410 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911000411 FAD binding site [chemical binding]; other site 1037911000412 substrate binding pocket [chemical binding]; other site 1037911000413 catalytic base [active] 1037911000414 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1037911000415 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1037911000416 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1037911000417 Cache domain; Region: Cache_1; pfam02743 1037911000418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911000419 dimerization interface [polypeptide binding]; other site 1037911000420 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911000421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911000422 dimer interface [polypeptide binding]; other site 1037911000423 putative CheW interface [polypeptide binding]; other site 1037911000424 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911000425 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1037911000426 acyl-activating enzyme (AAE) consensus motif; other site 1037911000427 AMP binding site [chemical binding]; other site 1037911000428 thioester reductase domain; Region: Thioester-redct; TIGR01746 1037911000429 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1037911000430 putative NAD(P) binding site [chemical binding]; other site 1037911000431 active site 1037911000432 putative substrate binding site [chemical binding]; other site 1037911000433 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1037911000434 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 1037911000435 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1037911000436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911000437 DNA-binding site [nucleotide binding]; DNA binding site 1037911000438 FCD domain; Region: FCD; pfam07729 1037911000439 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1037911000440 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1037911000441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911000442 dimerization interface [polypeptide binding]; other site 1037911000443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911000444 metal binding site [ion binding]; metal-binding site 1037911000445 active site 1037911000446 I-site; other site 1037911000447 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911000448 Calx-beta domain; Region: Calx-beta; cl02522 1037911000449 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1037911000450 metal ion-dependent adhesion site (MIDAS); other site 1037911000451 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1037911000452 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1037911000453 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1037911000454 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911000455 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911000456 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1037911000457 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1037911000458 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1037911000459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911000460 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1037911000461 putative substrate binding pocket [chemical binding]; other site 1037911000462 putative dimerization interface [polypeptide binding]; other site 1037911000463 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1037911000464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911000465 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1037911000466 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911000467 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911000468 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1037911000469 RNA polymerase sigma factor; Provisional; Region: PRK12528 1037911000470 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911000471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911000472 DNA binding residues [nucleotide binding] 1037911000473 fec operon regulator FecR; Reviewed; Region: PRK09774 1037911000474 FecR protein; Region: FecR; pfam04773 1037911000475 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911000476 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1037911000477 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911000478 N-terminal plug; other site 1037911000479 ligand-binding site [chemical binding]; other site 1037911000480 HipA N-terminal domain; Region: Couple_hipA; cl11853 1037911000481 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1037911000482 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1037911000483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1037911000484 non-specific DNA binding site [nucleotide binding]; other site 1037911000485 salt bridge; other site 1037911000486 sequence-specific DNA binding site [nucleotide binding]; other site 1037911000487 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1037911000488 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1037911000489 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1037911000490 Fic/DOC family; Region: Fic; pfam02661 1037911000491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1037911000492 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1037911000493 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1037911000494 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1037911000495 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1037911000496 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1037911000497 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911000498 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911000499 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1037911000500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1037911000501 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1037911000502 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1037911000503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911000504 TPR motif; other site 1037911000505 binding surface 1037911000506 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1037911000507 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1037911000508 putative active site [active] 1037911000509 putative metal binding site [ion binding]; other site 1037911000510 N-glycosyltransferase; Provisional; Region: PRK11204 1037911000511 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1037911000512 DXD motif; other site 1037911000513 PgaD-like protein; Region: PgaD; pfam13994 1037911000514 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1037911000515 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1037911000516 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1037911000517 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1037911000518 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1037911000519 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1037911000520 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911000521 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911000522 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911000523 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1037911000524 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1037911000525 protein-splicing catalytic site; other site 1037911000526 thioester formation/cholesterol transfer; other site 1037911000527 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1037911000528 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1037911000529 Competence protein J (ComJ); Region: ComJ; pfam11033 1037911000530 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1037911000531 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 1037911000532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1037911000533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 1037911000534 von Willebrand factor; Region: vWF_A; pfam12450 1037911000535 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1037911000536 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1037911000537 metal ion-dependent adhesion site (MIDAS); other site 1037911000538 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1037911000539 RNA polymerase sigma factor; Provisional; Region: PRK12513 1037911000540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911000541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911000542 DNA binding residues [nucleotide binding] 1037911000543 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1037911000544 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1037911000545 putative NADP binding site [chemical binding]; other site 1037911000546 putative substrate binding site [chemical binding]; other site 1037911000547 active site 1037911000548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911000549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911000550 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911000551 dimerization interface [polypeptide binding]; other site 1037911000552 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1037911000553 MltA-interacting protein MipA; Region: MipA; cl01504 1037911000554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911000555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911000556 active site 1037911000557 phosphorylation site [posttranslational modification] 1037911000558 intermolecular recognition site; other site 1037911000559 dimerization interface [polypeptide binding]; other site 1037911000560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911000561 DNA binding site [nucleotide binding] 1037911000562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911000563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911000564 dimerization interface [polypeptide binding]; other site 1037911000565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911000566 dimer interface [polypeptide binding]; other site 1037911000567 phosphorylation site [posttranslational modification] 1037911000568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911000569 ATP binding site [chemical binding]; other site 1037911000570 Mg2+ binding site [ion binding]; other site 1037911000571 G-X-G motif; other site 1037911000572 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1037911000573 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1037911000574 ligand binding site [chemical binding]; other site 1037911000575 flexible hinge region; other site 1037911000576 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1037911000577 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1037911000578 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1037911000579 Killing trait; Region: RebB; pfam11747 1037911000580 Killing trait; Region: RebB; pfam11747 1037911000581 Killing trait; Region: RebB; pfam11747 1037911000582 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1037911000583 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1037911000584 tetramerization interface [polypeptide binding]; other site 1037911000585 NAD(P) binding site [chemical binding]; other site 1037911000586 catalytic residues [active] 1037911000587 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1037911000588 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911000589 inhibitor-cofactor binding pocket; inhibition site 1037911000590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911000591 catalytic residue [active] 1037911000592 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911000593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911000594 active site 1037911000595 phosphorylation site [posttranslational modification] 1037911000596 intermolecular recognition site; other site 1037911000597 dimerization interface [polypeptide binding]; other site 1037911000598 HDOD domain; Region: HDOD; pfam08668 1037911000599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911000600 PAS domain; Region: PAS_9; pfam13426 1037911000601 putative active site [active] 1037911000602 heme pocket [chemical binding]; other site 1037911000603 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1037911000604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911000605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911000606 metal binding site [ion binding]; metal-binding site 1037911000607 active site 1037911000608 I-site; other site 1037911000609 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1037911000610 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1037911000611 Di-iron ligands [ion binding]; other site 1037911000612 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1037911000613 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1037911000614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911000615 PAS domain; Region: PAS_9; pfam13426 1037911000616 putative active site [active] 1037911000617 heme pocket [chemical binding]; other site 1037911000618 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911000619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911000620 metal binding site [ion binding]; metal-binding site 1037911000621 active site 1037911000622 I-site; other site 1037911000623 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911000624 Uncharacterized small protein [Function unknown]; Region: COG5583 1037911000625 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1037911000626 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1037911000627 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1037911000628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000629 dimer interface [polypeptide binding]; other site 1037911000630 conserved gate region; other site 1037911000631 putative PBP binding loops; other site 1037911000632 ABC-ATPase subunit interface; other site 1037911000633 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1037911000634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000635 dimer interface [polypeptide binding]; other site 1037911000636 conserved gate region; other site 1037911000637 putative PBP binding loops; other site 1037911000638 ABC-ATPase subunit interface; other site 1037911000639 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1037911000640 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1037911000641 Walker A/P-loop; other site 1037911000642 ATP binding site [chemical binding]; other site 1037911000643 Q-loop/lid; other site 1037911000644 ABC transporter signature motif; other site 1037911000645 Walker B; other site 1037911000646 D-loop; other site 1037911000647 H-loop/switch region; other site 1037911000648 TOBE-like domain; Region: TOBE_3; pfam12857 1037911000649 Predicted membrane protein [Function unknown]; Region: COG4539 1037911000650 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1037911000651 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1037911000652 ligand binding site [chemical binding]; other site 1037911000653 flexible hinge region; other site 1037911000654 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1037911000655 putative switch regulator; other site 1037911000656 non-specific DNA interactions [nucleotide binding]; other site 1037911000657 DNA binding site [nucleotide binding] 1037911000658 sequence specific DNA binding site [nucleotide binding]; other site 1037911000659 putative cAMP binding site [chemical binding]; other site 1037911000660 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1037911000661 active site 1037911000662 homotetramer interface [polypeptide binding]; other site 1037911000663 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1037911000664 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911000665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911000666 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1037911000667 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1037911000668 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1037911000669 Walker A/P-loop; other site 1037911000670 ATP binding site [chemical binding]; other site 1037911000671 Q-loop/lid; other site 1037911000672 ABC transporter signature motif; other site 1037911000673 Walker B; other site 1037911000674 D-loop; other site 1037911000675 H-loop/switch region; other site 1037911000676 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1037911000677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1037911000678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1037911000679 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1037911000680 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1037911000681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911000682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911000683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911000684 dimerization interface [polypeptide binding]; other site 1037911000685 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1037911000686 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1037911000687 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1037911000688 Sulfatase; Region: Sulfatase; cl17466 1037911000689 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1037911000690 nucleotide binding site/active site [active] 1037911000691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911000692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911000693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911000694 dimerization interface [polypeptide binding]; other site 1037911000695 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911000696 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911000697 N-terminal plug; other site 1037911000698 ligand-binding site [chemical binding]; other site 1037911000699 cyanate transporter; Region: CynX; TIGR00896 1037911000700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911000701 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1037911000702 nucleoside/Zn binding site; other site 1037911000703 dimer interface [polypeptide binding]; other site 1037911000704 catalytic motif [active] 1037911000705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911000706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911000707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911000708 dimerization interface [polypeptide binding]; other site 1037911000709 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1037911000710 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1037911000711 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1037911000712 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1037911000713 TolR protein; Region: tolR; TIGR02801 1037911000714 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1037911000715 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1037911000716 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911000717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911000718 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1037911000719 Walker A motif; other site 1037911000720 ATP binding site [chemical binding]; other site 1037911000721 Walker B motif; other site 1037911000722 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1037911000723 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1037911000724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000725 dimer interface [polypeptide binding]; other site 1037911000726 conserved gate region; other site 1037911000727 putative PBP binding loops; other site 1037911000728 ABC-ATPase subunit interface; other site 1037911000729 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911000730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000731 dimer interface [polypeptide binding]; other site 1037911000732 conserved gate region; other site 1037911000733 putative PBP binding loops; other site 1037911000734 ABC-ATPase subunit interface; other site 1037911000735 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1037911000736 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911000737 Walker A/P-loop; other site 1037911000738 ATP binding site [chemical binding]; other site 1037911000739 Q-loop/lid; other site 1037911000740 ABC transporter signature motif; other site 1037911000741 Walker B; other site 1037911000742 D-loop; other site 1037911000743 H-loop/switch region; other site 1037911000744 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1037911000745 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911000746 substrate binding pocket [chemical binding]; other site 1037911000747 membrane-bound complex binding site; other site 1037911000748 hinge residues; other site 1037911000749 Predicted ATPase [General function prediction only]; Region: COG4637 1037911000750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911000751 Walker A/P-loop; other site 1037911000752 ATP binding site [chemical binding]; other site 1037911000753 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911000754 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911000755 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911000756 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911000757 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1037911000758 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 1037911000759 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1037911000760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911000761 S-adenosylmethionine binding site [chemical binding]; other site 1037911000762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000763 dimer interface [polypeptide binding]; other site 1037911000764 conserved gate region; other site 1037911000765 ABC-ATPase subunit interface; other site 1037911000766 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1037911000767 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1037911000768 Walker A/P-loop; other site 1037911000769 ATP binding site [chemical binding]; other site 1037911000770 Q-loop/lid; other site 1037911000771 ABC transporter signature motif; other site 1037911000772 Walker B; other site 1037911000773 D-loop; other site 1037911000774 H-loop/switch region; other site 1037911000775 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1037911000776 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1037911000777 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1037911000778 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1037911000779 non-prolyl cis peptide bond; other site 1037911000780 active site 1037911000781 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1037911000782 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1037911000783 Flavin binding site [chemical binding]; other site 1037911000784 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1037911000785 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1037911000786 Flavin binding site [chemical binding]; other site 1037911000787 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1037911000788 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911000789 Walker A/P-loop; other site 1037911000790 ATP binding site [chemical binding]; other site 1037911000791 Q-loop/lid; other site 1037911000792 ABC transporter signature motif; other site 1037911000793 Walker B; other site 1037911000794 D-loop; other site 1037911000795 H-loop/switch region; other site 1037911000796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000797 dimer interface [polypeptide binding]; other site 1037911000798 conserved gate region; other site 1037911000799 putative PBP binding loops; other site 1037911000800 ABC-ATPase subunit interface; other site 1037911000801 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911000802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911000803 substrate binding pocket [chemical binding]; other site 1037911000804 membrane-bound complex binding site; other site 1037911000805 hinge residues; other site 1037911000806 D-cysteine desulfhydrase; Validated; Region: PRK03910 1037911000807 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1037911000808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911000809 catalytic residue [active] 1037911000810 serine O-acetyltransferase; Region: cysE; TIGR01172 1037911000811 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1037911000812 trimer interface [polypeptide binding]; other site 1037911000813 active site 1037911000814 substrate binding site [chemical binding]; other site 1037911000815 CoA binding site [chemical binding]; other site 1037911000816 BCCT family transporter; Region: BCCT; cl00569 1037911000817 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1037911000818 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1037911000819 active site 1037911000820 catalytic tetrad [active] 1037911000821 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1037911000822 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1037911000823 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1037911000824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000825 dimer interface [polypeptide binding]; other site 1037911000826 conserved gate region; other site 1037911000827 putative PBP binding loops; other site 1037911000828 ABC-ATPase subunit interface; other site 1037911000829 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1037911000830 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1037911000831 Walker A/P-loop; other site 1037911000832 ATP binding site [chemical binding]; other site 1037911000833 Q-loop/lid; other site 1037911000834 ABC transporter signature motif; other site 1037911000835 Walker B; other site 1037911000836 D-loop; other site 1037911000837 H-loop/switch region; other site 1037911000838 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1037911000839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911000840 substrate binding pocket [chemical binding]; other site 1037911000841 membrane-bound complex binding site; other site 1037911000842 hinge residues; other site 1037911000843 glutamate--cysteine ligase; Provisional; Region: PRK02107 1037911000844 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1037911000845 CoenzymeA binding site [chemical binding]; other site 1037911000846 subunit interaction site [polypeptide binding]; other site 1037911000847 PHB binding site; other site 1037911000848 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1037911000849 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1037911000850 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1037911000851 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1037911000852 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1037911000853 RNA binding site [nucleotide binding]; other site 1037911000854 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1037911000855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911000856 active site 1037911000857 phosphorylation site [posttranslational modification] 1037911000858 intermolecular recognition site; other site 1037911000859 dimerization interface [polypeptide binding]; other site 1037911000860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911000861 DNA binding site [nucleotide binding] 1037911000862 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1037911000863 HAMP domain; Region: HAMP; pfam00672 1037911000864 dimerization interface [polypeptide binding]; other site 1037911000865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911000866 ATP binding site [chemical binding]; other site 1037911000867 Mg2+ binding site [ion binding]; other site 1037911000868 G-X-G motif; other site 1037911000869 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1037911000870 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1037911000871 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1037911000872 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911000873 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1037911000874 RNA binding surface [nucleotide binding]; other site 1037911000875 PAP2 superfamily; Region: PAP2; pfam01569 1037911000876 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1037911000877 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1037911000878 dimerization interface [polypeptide binding]; other site 1037911000879 domain crossover interface; other site 1037911000880 redox-dependent activation switch; other site 1037911000881 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1037911000882 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1037911000883 active site 1037911000884 substrate-binding site [chemical binding]; other site 1037911000885 metal-binding site [ion binding] 1037911000886 ATP binding site [chemical binding]; other site 1037911000887 EamA-like transporter family; Region: EamA; cl17759 1037911000888 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1037911000889 Fic/DOC family; Region: Fic; cl00960 1037911000890 TPR repeat; Region: TPR_11; pfam13414 1037911000891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911000892 binding surface 1037911000893 TPR motif; other site 1037911000894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1037911000895 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1037911000896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911000897 ATP binding site [chemical binding]; other site 1037911000898 putative Mg++ binding site [ion binding]; other site 1037911000899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911000900 nucleotide binding region [chemical binding]; other site 1037911000901 ATP-binding site [chemical binding]; other site 1037911000902 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1037911000903 active site 1037911000904 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1037911000905 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1037911000906 putative molybdopterin cofactor binding site [chemical binding]; other site 1037911000907 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1037911000908 putative molybdopterin cofactor binding site; other site 1037911000909 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 1037911000910 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1037911000911 BON domain; Region: BON; pfam04972 1037911000912 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1037911000913 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1037911000914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911000915 motif II; other site 1037911000916 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1037911000917 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1037911000918 dimer interface [polypeptide binding]; other site 1037911000919 ADP-ribose binding site [chemical binding]; other site 1037911000920 active site 1037911000921 nudix motif; other site 1037911000922 metal binding site [ion binding]; metal-binding site 1037911000923 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1037911000924 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1037911000925 active site 1037911000926 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1037911000927 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911000928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911000929 active site 1037911000930 phosphorylation site [posttranslational modification] 1037911000931 intermolecular recognition site; other site 1037911000932 dimerization interface [polypeptide binding]; other site 1037911000933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911000934 Walker A motif; other site 1037911000935 ATP binding site [chemical binding]; other site 1037911000936 Walker B motif; other site 1037911000937 arginine finger; other site 1037911000938 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1037911000939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911000940 dimer interface [polypeptide binding]; other site 1037911000941 phosphorylation site [posttranslational modification] 1037911000942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911000943 ATP binding site [chemical binding]; other site 1037911000944 G-X-G motif; other site 1037911000945 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1037911000946 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1037911000947 NADP binding site [chemical binding]; other site 1037911000948 active site 1037911000949 putative substrate binding site [chemical binding]; other site 1037911000950 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1037911000951 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1037911000952 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1037911000953 substrate binding site; other site 1037911000954 tetramer interface; other site 1037911000955 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1037911000956 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1037911000957 NAD binding site [chemical binding]; other site 1037911000958 substrate binding site [chemical binding]; other site 1037911000959 homodimer interface [polypeptide binding]; other site 1037911000960 active site 1037911000961 hypothetical protein; Provisional; Region: PRK06149 1037911000962 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1037911000963 active site 1037911000964 substrate binding site [chemical binding]; other site 1037911000965 ATP binding site [chemical binding]; other site 1037911000966 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911000967 inhibitor-cofactor binding pocket; inhibition site 1037911000968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911000969 catalytic residue [active] 1037911000970 agmatine deiminase; Provisional; Region: PRK13551 1037911000971 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1037911000972 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1037911000973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911000974 N-terminal plug; other site 1037911000975 ligand-binding site [chemical binding]; other site 1037911000976 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911000977 Peptidase family M48; Region: Peptidase_M48; cl12018 1037911000978 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 1037911000979 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1037911000980 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911000981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000982 dimer interface [polypeptide binding]; other site 1037911000983 conserved gate region; other site 1037911000984 putative PBP binding loops; other site 1037911000985 ABC-ATPase subunit interface; other site 1037911000986 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911000987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911000988 dimer interface [polypeptide binding]; other site 1037911000989 conserved gate region; other site 1037911000990 putative PBP binding loops; other site 1037911000991 ABC-ATPase subunit interface; other site 1037911000992 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911000993 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911000994 substrate binding pocket [chemical binding]; other site 1037911000995 membrane-bound complex binding site; other site 1037911000996 hinge residues; other site 1037911000997 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1037911000998 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911000999 Walker A/P-loop; other site 1037911001000 ATP binding site [chemical binding]; other site 1037911001001 Q-loop/lid; other site 1037911001002 ABC transporter signature motif; other site 1037911001003 Walker B; other site 1037911001004 D-loop; other site 1037911001005 H-loop/switch region; other site 1037911001006 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1037911001007 Spore germination protein; Region: Spore_permease; cl17796 1037911001008 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1037911001009 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1037911001010 oxidative damage protection protein; Provisional; Region: PRK05408 1037911001011 adenine DNA glycosylase; Provisional; Region: PRK10880 1037911001012 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1037911001013 minor groove reading motif; other site 1037911001014 helix-hairpin-helix signature motif; other site 1037911001015 substrate binding pocket [chemical binding]; other site 1037911001016 active site 1037911001017 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1037911001018 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1037911001019 DNA binding and oxoG recognition site [nucleotide binding] 1037911001020 AsmA family; Region: AsmA; pfam05170 1037911001021 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1037911001022 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1037911001023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911001024 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1037911001025 putative active site pocket [active] 1037911001026 4-fold oligomerization interface [polypeptide binding]; other site 1037911001027 metal binding residues [ion binding]; metal-binding site 1037911001028 3-fold/trimer interface [polypeptide binding]; other site 1037911001029 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1037911001030 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1037911001031 putative active site [active] 1037911001032 oxyanion strand; other site 1037911001033 catalytic triad [active] 1037911001034 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1037911001035 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1037911001036 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1037911001037 catalytic residues [active] 1037911001038 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1037911001039 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1037911001040 substrate binding site [chemical binding]; other site 1037911001041 glutamase interaction surface [polypeptide binding]; other site 1037911001042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911001043 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911001044 substrate binding pocket [chemical binding]; other site 1037911001045 membrane-bound complex binding site; other site 1037911001046 hinge residues; other site 1037911001047 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1037911001048 NodB motif; other site 1037911001049 putative active site [active] 1037911001050 putative catalytic site [active] 1037911001051 Zn binding site [ion binding]; other site 1037911001052 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1037911001053 C-terminal peptidase (prc); Region: prc; TIGR00225 1037911001054 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1037911001055 protein binding site [polypeptide binding]; other site 1037911001056 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1037911001057 Catalytic dyad [active] 1037911001058 phosphoglyceromutase; Provisional; Region: PRK05434 1037911001059 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1037911001060 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1037911001061 active site residue [active] 1037911001062 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1037911001063 GSH binding site [chemical binding]; other site 1037911001064 catalytic residues [active] 1037911001065 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1037911001066 SecA binding site; other site 1037911001067 Preprotein binding site; other site 1037911001068 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1037911001069 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1037911001070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911001071 active site 1037911001072 phosphorylation site [posttranslational modification] 1037911001073 intermolecular recognition site; other site 1037911001074 dimerization interface [polypeptide binding]; other site 1037911001075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911001076 Walker A motif; other site 1037911001077 ATP binding site [chemical binding]; other site 1037911001078 Walker B motif; other site 1037911001079 arginine finger; other site 1037911001080 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911001081 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1037911001082 PAS domain; Region: PAS; smart00091 1037911001083 putative active site [active] 1037911001084 heme pocket [chemical binding]; other site 1037911001085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911001086 dimer interface [polypeptide binding]; other site 1037911001087 phosphorylation site [posttranslational modification] 1037911001088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911001089 ATP binding site [chemical binding]; other site 1037911001090 Mg2+ binding site [ion binding]; other site 1037911001091 G-X-G motif; other site 1037911001092 chorismate mutase; Provisional; Region: PRK09269 1037911001093 Chorismate mutase type II; Region: CM_2; cl00693 1037911001094 glutamine synthetase; Provisional; Region: glnA; PRK09469 1037911001095 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1037911001096 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1037911001097 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1037911001098 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1037911001099 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1037911001100 Ligand Binding Site [chemical binding]; other site 1037911001101 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1037911001102 active site residue [active] 1037911001103 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1037911001104 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1037911001105 G1 box; other site 1037911001106 putative GEF interaction site [polypeptide binding]; other site 1037911001107 GTP/Mg2+ binding site [chemical binding]; other site 1037911001108 Switch I region; other site 1037911001109 G2 box; other site 1037911001110 G3 box; other site 1037911001111 Switch II region; other site 1037911001112 G4 box; other site 1037911001113 G5 box; other site 1037911001114 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1037911001115 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1037911001116 Flagellin N-methylase; Region: FliB; pfam03692 1037911001117 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1037911001118 homodimer interface [polypeptide binding]; other site 1037911001119 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1037911001120 active site pocket [active] 1037911001121 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1037911001122 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1037911001123 AMP binding site [chemical binding]; other site 1037911001124 metal binding site [ion binding]; metal-binding site 1037911001125 active site 1037911001126 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1037911001127 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1037911001128 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1037911001129 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1037911001130 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1037911001131 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1037911001132 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1037911001133 active site 1037911001134 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1037911001135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911001136 DNA-binding site [nucleotide binding]; DNA binding site 1037911001137 UTRA domain; Region: UTRA; pfam07702 1037911001138 HutD; Region: HutD; pfam05962 1037911001139 urocanate hydratase; Provisional; Region: PRK05414 1037911001140 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1037911001141 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1037911001142 Na binding site [ion binding]; other site 1037911001143 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1037911001144 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1037911001145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911001146 dimer interface [polypeptide binding]; other site 1037911001147 conserved gate region; other site 1037911001148 putative PBP binding loops; other site 1037911001149 ABC-ATPase subunit interface; other site 1037911001150 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1037911001151 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1037911001152 Walker A/P-loop; other site 1037911001153 ATP binding site [chemical binding]; other site 1037911001154 Q-loop/lid; other site 1037911001155 ABC transporter signature motif; other site 1037911001156 Walker B; other site 1037911001157 D-loop; other site 1037911001158 H-loop/switch region; other site 1037911001159 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1037911001160 active sites [active] 1037911001161 tetramer interface [polypeptide binding]; other site 1037911001162 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1037911001163 active sites [active] 1037911001164 tetramer interface [polypeptide binding]; other site 1037911001165 putative proline-specific permease; Provisional; Region: proY; PRK10580 1037911001166 imidazolonepropionase; Validated; Region: PRK09356 1037911001167 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1037911001168 active site 1037911001169 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1037911001170 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1037911001171 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1037911001172 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1037911001173 putative active site [active] 1037911001174 dimerization interface [polypeptide binding]; other site 1037911001175 putative tRNAtyr binding site [nucleotide binding]; other site 1037911001176 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1037911001177 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1037911001178 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1037911001179 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1037911001180 Ligand binding site; other site 1037911001181 DXD motif; other site 1037911001182 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911001183 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911001184 substrate binding pocket [chemical binding]; other site 1037911001185 membrane-bound complex binding site; other site 1037911001186 hinge residues; other site 1037911001187 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911001188 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911001189 substrate binding pocket [chemical binding]; other site 1037911001190 membrane-bound complex binding site; other site 1037911001191 hinge residues; other site 1037911001192 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911001194 dimer interface [polypeptide binding]; other site 1037911001195 conserved gate region; other site 1037911001196 putative PBP binding loops; other site 1037911001197 ABC-ATPase subunit interface; other site 1037911001198 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1037911001199 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911001200 Walker A/P-loop; other site 1037911001201 ATP binding site [chemical binding]; other site 1037911001202 Q-loop/lid; other site 1037911001203 ABC transporter signature motif; other site 1037911001204 Walker B; other site 1037911001205 D-loop; other site 1037911001206 H-loop/switch region; other site 1037911001207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911001208 dimerization interface [polypeptide binding]; other site 1037911001209 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911001210 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911001211 dimer interface [polypeptide binding]; other site 1037911001212 putative CheW interface [polypeptide binding]; other site 1037911001213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911001214 dimerization interface [polypeptide binding]; other site 1037911001215 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911001216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911001217 dimer interface [polypeptide binding]; other site 1037911001218 putative CheW interface [polypeptide binding]; other site 1037911001219 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1037911001220 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1037911001221 sec-independent translocase; Provisional; Region: tatB; PRK00404 1037911001222 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1037911001223 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 1037911001224 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1037911001225 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1037911001226 metal binding site [ion binding]; metal-binding site 1037911001227 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1037911001228 ABC1 family; Region: ABC1; cl17513 1037911001229 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1037911001230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1037911001231 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1037911001232 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1037911001233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911001234 S-adenosylmethionine binding site [chemical binding]; other site 1037911001235 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 1037911001236 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1037911001237 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1037911001238 Fimbrial protein; Region: Fimbrial; pfam00419 1037911001239 Fimbrial protein; Region: Fimbrial; pfam00419 1037911001240 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1037911001241 PapC N-terminal domain; Region: PapC_N; pfam13954 1037911001242 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1037911001243 PapC C-terminal domain; Region: PapC_C; pfam13953 1037911001244 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1037911001245 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1037911001246 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1037911001247 putative chaperone protein EcpD; Provisional; Region: PRK09926 1037911001248 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1037911001249 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1037911001250 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1037911001251 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911001252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911001253 active site 1037911001254 phosphorylation site [posttranslational modification] 1037911001255 intermolecular recognition site; other site 1037911001256 dimerization interface [polypeptide binding]; other site 1037911001257 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911001258 DNA binding residues [nucleotide binding] 1037911001259 dimerization interface [polypeptide binding]; other site 1037911001260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911001261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911001262 Bacterial transcriptional repressor; Region: TetR; pfam13972 1037911001263 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1037911001264 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1037911001265 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1037911001266 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1037911001267 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1037911001268 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1037911001269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1037911001270 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1037911001271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911001272 Walker A motif; other site 1037911001273 ATP binding site [chemical binding]; other site 1037911001274 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1037911001275 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1037911001276 active site 1037911001277 HslU subunit interaction site [polypeptide binding]; other site 1037911001278 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 1037911001279 Sporulation related domain; Region: SPOR; pfam05036 1037911001280 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1037911001281 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1037911001282 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1037911001283 active site 1037911001284 HIGH motif; other site 1037911001285 KMSK motif region; other site 1037911001286 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1037911001287 tRNA binding surface [nucleotide binding]; other site 1037911001288 anticodon binding site; other site 1037911001289 primosome assembly protein PriA; Validated; Region: PRK05580 1037911001290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911001291 ATP binding site [chemical binding]; other site 1037911001292 putative Mg++ binding site [ion binding]; other site 1037911001293 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1037911001294 ATP-binding site [chemical binding]; other site 1037911001295 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1037911001296 Staphylococcal nuclease homologues; Region: SNc; smart00318 1037911001297 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1037911001298 Catalytic site; other site 1037911001299 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1037911001300 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1037911001301 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1037911001302 putative NAD(P) binding site [chemical binding]; other site 1037911001303 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1037911001304 Transglycosylase; Region: Transgly; pfam00912 1037911001305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1037911001306 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1037911001307 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1037911001308 Pilus assembly protein, PilO; Region: PilO; cl01234 1037911001309 Pilus assembly protein, PilP; Region: PilP; pfam04351 1037911001310 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1037911001311 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911001312 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1037911001313 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1037911001314 shikimate kinase; Reviewed; Region: aroK; PRK00131 1037911001315 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1037911001316 ADP binding site [chemical binding]; other site 1037911001317 magnesium binding site [ion binding]; other site 1037911001318 putative shikimate binding site; other site 1037911001319 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1037911001320 active site 1037911001321 dimer interface [polypeptide binding]; other site 1037911001322 metal binding site [ion binding]; metal-binding site 1037911001323 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1037911001324 Part of AAA domain; Region: AAA_19; pfam13245 1037911001325 Sporulation related domain; Region: SPOR; pfam05036 1037911001326 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1037911001327 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1037911001328 active site 1037911001329 dimer interface [polypeptide binding]; other site 1037911001330 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1037911001331 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1037911001332 active site 1037911001333 FMN binding site [chemical binding]; other site 1037911001334 substrate binding site [chemical binding]; other site 1037911001335 3Fe-4S cluster binding site [ion binding]; other site 1037911001336 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1037911001337 domain interface; other site 1037911001338 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1037911001339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911001340 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1037911001341 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1037911001342 substrate binding site [chemical binding]; other site 1037911001343 active site 1037911001344 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1037911001345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911001346 putative substrate translocation pore; other site 1037911001347 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1037911001348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911001349 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1037911001350 dimerization interface [polypeptide binding]; other site 1037911001351 substrate binding pocket [chemical binding]; other site 1037911001352 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1037911001353 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1037911001354 dimer interface [polypeptide binding]; other site 1037911001355 active site 1037911001356 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1037911001357 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1037911001358 NAD(P) binding site [chemical binding]; other site 1037911001359 homotetramer interface [polypeptide binding]; other site 1037911001360 homodimer interface [polypeptide binding]; other site 1037911001361 active site 1037911001362 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1037911001363 putative active site 1 [active] 1037911001364 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1037911001365 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1037911001366 dimer interface [polypeptide binding]; other site 1037911001367 active site 1037911001368 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1037911001369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911001370 S-adenosylmethionine binding site [chemical binding]; other site 1037911001371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1037911001372 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1037911001373 Predicted exporter [General function prediction only]; Region: COG4258 1037911001374 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1037911001375 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1037911001376 active site 1037911001377 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1037911001378 active sites [active] 1037911001379 tetramer interface [polypeptide binding]; other site 1037911001380 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1037911001381 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1037911001382 putative acyl-acceptor binding pocket; other site 1037911001383 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1037911001384 Ligand binding site; other site 1037911001385 Putative Catalytic site; other site 1037911001386 DXD motif; other site 1037911001387 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1037911001388 AMP-binding enzyme; Region: AMP-binding; pfam00501 1037911001389 active site 1037911001390 AMP binding site [chemical binding]; other site 1037911001391 acyl-activating enzyme (AAE) consensus motif; other site 1037911001392 CoA binding site [chemical binding]; other site 1037911001393 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1037911001394 active site 2 [active] 1037911001395 dimer interface [polypeptide binding]; other site 1037911001396 active site 1 [active] 1037911001397 Predicted membrane protein [Function unknown]; Region: COG4648 1037911001398 acyl carrier protein; Provisional; Region: PRK05350 1037911001399 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1037911001400 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1037911001401 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1037911001402 putative acyl-acceptor binding pocket; other site 1037911001403 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1037911001404 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1037911001405 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1037911001406 P-loop; other site 1037911001407 Magnesium ion binding site [ion binding]; other site 1037911001408 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1037911001409 Magnesium ion binding site [ion binding]; other site 1037911001410 thioredoxin 2; Provisional; Region: PRK10996 1037911001411 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1037911001412 catalytic residues [active] 1037911001413 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1037911001414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911001415 non-specific DNA binding site [nucleotide binding]; other site 1037911001416 salt bridge; other site 1037911001417 sequence-specific DNA binding site [nucleotide binding]; other site 1037911001418 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1037911001419 hypothetical protein; Validated; Region: PRK00029 1037911001420 hypothetical protein; Provisional; Region: PRK11281 1037911001421 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1037911001422 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1037911001423 potassium/proton antiporter; Reviewed; Region: PRK05326 1037911001424 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1037911001425 TrkA-C domain; Region: TrkA_C; pfam02080 1037911001426 Transporter associated domain; Region: CorC_HlyC; smart01091 1037911001427 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1037911001428 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911001429 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911001430 dimer interface [polypeptide binding]; other site 1037911001431 putative CheW interface [polypeptide binding]; other site 1037911001432 Cell division protein ZapA; Region: ZapA; pfam05164 1037911001433 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1037911001434 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1037911001435 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911001436 active site 1037911001437 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1037911001438 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1037911001439 Predicted transcriptional regulator [Transcription]; Region: COG3905 1037911001440 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1037911001441 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1037911001442 Glutamate binding site [chemical binding]; other site 1037911001443 NAD binding site [chemical binding]; other site 1037911001444 catalytic residues [active] 1037911001445 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1037911001446 Na binding site [ion binding]; other site 1037911001447 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1037911001448 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1037911001449 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1037911001450 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1037911001451 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1037911001452 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1037911001453 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1037911001454 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1037911001455 GAF domain; Region: GAF; pfam01590 1037911001456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911001457 PAS domain; Region: PAS_9; pfam13426 1037911001458 putative active site [active] 1037911001459 heme pocket [chemical binding]; other site 1037911001460 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911001461 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911001462 metal binding site [ion binding]; metal-binding site 1037911001463 active site 1037911001464 I-site; other site 1037911001465 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911001466 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1037911001467 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1037911001468 E3 interaction surface; other site 1037911001469 lipoyl attachment site [posttranslational modification]; other site 1037911001470 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1037911001471 E3 interaction surface; other site 1037911001472 lipoyl attachment site [posttranslational modification]; other site 1037911001473 e3 binding domain; Region: E3_binding; pfam02817 1037911001474 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1037911001475 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1037911001476 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1037911001477 dimer interface [polypeptide binding]; other site 1037911001478 TPP-binding site [chemical binding]; other site 1037911001479 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1037911001480 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1037911001481 metal binding triad; other site 1037911001482 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1037911001483 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1037911001484 metal binding triad; other site 1037911001485 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1037911001486 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1037911001487 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1037911001488 putative active site [active] 1037911001489 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1037911001490 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1037911001491 putative active site [active] 1037911001492 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911001493 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1037911001494 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1037911001495 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1037911001496 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1037911001497 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1037911001498 active site 1037911001499 ATP binding site [chemical binding]; other site 1037911001500 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1037911001501 active site 1037911001502 ATP binding site [chemical binding]; other site 1037911001503 substrate binding site [chemical binding]; other site 1037911001504 activation loop (A-loop); other site 1037911001505 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1037911001506 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911001507 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911001508 N-terminal plug; other site 1037911001509 ligand-binding site [chemical binding]; other site 1037911001510 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1037911001511 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1037911001512 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1037911001513 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1037911001514 Mig-14; Region: Mig-14; pfam07395 1037911001515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1037911001516 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1037911001517 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1037911001518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911001519 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1037911001520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1037911001521 active site 1037911001522 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1037911001523 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1037911001524 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1037911001525 active site 1037911001526 substrate binding site [chemical binding]; other site 1037911001527 ATP binding site [chemical binding]; other site 1037911001528 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1037911001529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1037911001530 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1037911001531 Walker A/P-loop; other site 1037911001532 ATP binding site [chemical binding]; other site 1037911001533 Q-loop/lid; other site 1037911001534 ABC transporter signature motif; other site 1037911001535 Walker B; other site 1037911001536 D-loop; other site 1037911001537 H-loop/switch region; other site 1037911001538 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1037911001539 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1037911001540 putative ribose interaction site [chemical binding]; other site 1037911001541 putative ADP binding site [chemical binding]; other site 1037911001542 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1037911001543 active site 1037911001544 nucleotide binding site [chemical binding]; other site 1037911001545 HIGH motif; other site 1037911001546 KMSKS motif; other site 1037911001547 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1037911001548 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1037911001549 active site 1037911001550 catalytic tetrad [active] 1037911001551 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1037911001552 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1037911001553 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911001554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911001555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911001556 dimerization interface [polypeptide binding]; other site 1037911001557 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1037911001558 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1037911001559 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1037911001560 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1037911001561 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1037911001562 ThiC-associated domain; Region: ThiC-associated; pfam13667 1037911001563 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1037911001564 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1037911001565 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1037911001566 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1037911001567 dimer interface [polypeptide binding]; other site 1037911001568 ADP-ribose binding site [chemical binding]; other site 1037911001569 active site 1037911001570 nudix motif; other site 1037911001571 metal binding site [ion binding]; metal-binding site 1037911001572 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 1037911001573 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1037911001574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1037911001575 active site 1037911001576 metal binding site [ion binding]; metal-binding site 1037911001577 hexamer interface [polypeptide binding]; other site 1037911001578 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1037911001579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911001580 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1037911001581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911001582 ATP binding site [chemical binding]; other site 1037911001583 Mg2+ binding site [ion binding]; other site 1037911001584 G-X-G motif; other site 1037911001585 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1037911001586 anchoring element; other site 1037911001587 dimer interface [polypeptide binding]; other site 1037911001588 ATP binding site [chemical binding]; other site 1037911001589 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1037911001590 active site 1037911001591 metal binding site [ion binding]; metal-binding site 1037911001592 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1037911001593 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1037911001594 SdiA-regulated; Region: SdiA-regulated; cd09971 1037911001595 putative active site [active] 1037911001596 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1037911001597 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1037911001598 CAP-like domain; other site 1037911001599 active site 1037911001600 primary dimer interface [polypeptide binding]; other site 1037911001601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1037911001602 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1037911001603 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 1037911001604 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1037911001605 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1037911001606 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1037911001607 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1037911001608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911001609 motif II; other site 1037911001610 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1037911001611 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1037911001612 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1037911001613 active site residue [active] 1037911001614 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1037911001615 active site residue [active] 1037911001616 HDOD domain; Region: HDOD; pfam08668 1037911001617 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1037911001618 flagellar motor protein MotA; Validated; Region: PRK09110 1037911001619 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1037911001620 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1037911001621 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911001622 ligand binding site [chemical binding]; other site 1037911001623 PemK-like protein; Region: PemK; cl00995 1037911001624 GTPase RsgA; Reviewed; Region: PRK12288 1037911001625 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1037911001626 RNA binding site [nucleotide binding]; other site 1037911001627 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1037911001628 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1037911001629 GTP/Mg2+ binding site [chemical binding]; other site 1037911001630 G4 box; other site 1037911001631 G5 box; other site 1037911001632 G1 box; other site 1037911001633 Switch I region; other site 1037911001634 G2 box; other site 1037911001635 G3 box; other site 1037911001636 Switch II region; other site 1037911001637 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1037911001638 catalytic site [active] 1037911001639 putative active site [active] 1037911001640 putative substrate binding site [chemical binding]; other site 1037911001641 dimer interface [polypeptide binding]; other site 1037911001642 Predicted membrane protein [Function unknown]; Region: COG2860 1037911001643 UPF0126 domain; Region: UPF0126; pfam03458 1037911001644 UPF0126 domain; Region: UPF0126; pfam03458 1037911001645 epoxyqueuosine reductase; Region: TIGR00276 1037911001646 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1037911001647 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1037911001648 putative substrate binding site [chemical binding]; other site 1037911001649 putative ATP binding site [chemical binding]; other site 1037911001650 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1037911001651 AMIN domain; Region: AMIN; pfam11741 1037911001652 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1037911001653 active site 1037911001654 metal binding site [ion binding]; metal-binding site 1037911001655 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1037911001656 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1037911001657 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1037911001658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911001659 ATP binding site [chemical binding]; other site 1037911001660 Mg2+ binding site [ion binding]; other site 1037911001661 G-X-G motif; other site 1037911001662 Mitochondrial ribosomal subunit protein; Region: MRP-S28; pfam10213 1037911001663 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1037911001664 ATP binding site [chemical binding]; other site 1037911001665 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1037911001666 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1037911001667 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 1037911001668 bacterial Hfq-like; Region: Hfq; cd01716 1037911001669 hexamer interface [polypeptide binding]; other site 1037911001670 Sm1 motif; other site 1037911001671 RNA binding site [nucleotide binding]; other site 1037911001672 Sm2 motif; other site 1037911001673 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1037911001674 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1037911001675 HflX GTPase family; Region: HflX; cd01878 1037911001676 G1 box; other site 1037911001677 GTP/Mg2+ binding site [chemical binding]; other site 1037911001678 Switch I region; other site 1037911001679 G2 box; other site 1037911001680 G3 box; other site 1037911001681 Switch II region; other site 1037911001682 G4 box; other site 1037911001683 G5 box; other site 1037911001684 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1037911001685 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1037911001686 HflK protein; Region: hflK; TIGR01933 1037911001687 FtsH protease regulator HflC; Provisional; Region: PRK11029 1037911001688 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1037911001689 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1037911001690 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1037911001691 dimer interface [polypeptide binding]; other site 1037911001692 motif 1; other site 1037911001693 active site 1037911001694 motif 2; other site 1037911001695 motif 3; other site 1037911001696 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1037911001697 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1037911001698 GDP-binding site [chemical binding]; other site 1037911001699 ACT binding site; other site 1037911001700 IMP binding site; other site 1037911001701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911001702 dimerization interface [polypeptide binding]; other site 1037911001703 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911001704 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911001705 dimer interface [polypeptide binding]; other site 1037911001706 putative CheW interface [polypeptide binding]; other site 1037911001707 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1037911001708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911001709 dimer interface [polypeptide binding]; other site 1037911001710 conserved gate region; other site 1037911001711 putative PBP binding loops; other site 1037911001712 ABC-ATPase subunit interface; other site 1037911001713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911001714 dimer interface [polypeptide binding]; other site 1037911001715 conserved gate region; other site 1037911001716 putative PBP binding loops; other site 1037911001717 ABC-ATPase subunit interface; other site 1037911001718 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1037911001719 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1037911001720 ribonuclease R; Region: RNase_R; TIGR02063 1037911001721 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1037911001722 RNB domain; Region: RNB; pfam00773 1037911001723 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1037911001724 RNA binding site [nucleotide binding]; other site 1037911001725 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1037911001726 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1037911001727 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1037911001728 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1037911001729 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1037911001730 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1037911001731 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1037911001732 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1037911001733 replicative DNA helicase; Provisional; Region: PRK05748 1037911001734 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1037911001735 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1037911001736 Walker A motif; other site 1037911001737 ATP binding site [chemical binding]; other site 1037911001738 Walker B motif; other site 1037911001739 DNA binding loops [nucleotide binding] 1037911001740 hypothetical protein; Provisional; Region: PRK01254 1037911001741 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1037911001742 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1037911001743 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1037911001744 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1037911001745 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1037911001746 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1037911001747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1037911001748 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1037911001749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1037911001750 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1037911001751 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1037911001752 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1037911001753 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1037911001754 azurin; Region: azurin; TIGR02695 1037911001755 NAD synthase; Region: NAD_synthase; pfam02540 1037911001756 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1037911001757 homodimer interface [polypeptide binding]; other site 1037911001758 NAD binding pocket [chemical binding]; other site 1037911001759 ATP binding pocket [chemical binding]; other site 1037911001760 Mg binding site [ion binding]; other site 1037911001761 active-site loop [active] 1037911001762 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1037911001763 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1037911001764 active site 1037911001765 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1037911001766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911001767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911001768 dimerization interface [polypeptide binding]; other site 1037911001769 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1037911001770 aldehyde dehydrogenase family 7 member; Region: PLN02315 1037911001771 tetrameric interface [polypeptide binding]; other site 1037911001772 NAD binding site [chemical binding]; other site 1037911001773 catalytic residues [active] 1037911001774 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1037911001775 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911001776 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1037911001777 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1037911001778 dimerization interface [polypeptide binding]; other site 1037911001779 ligand binding site [chemical binding]; other site 1037911001780 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911001781 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1037911001782 TM-ABC transporter signature motif; other site 1037911001783 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1037911001784 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1037911001785 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1037911001786 TM-ABC transporter signature motif; other site 1037911001787 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1037911001788 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1037911001789 Walker A/P-loop; other site 1037911001790 ATP binding site [chemical binding]; other site 1037911001791 Q-loop/lid; other site 1037911001792 ABC transporter signature motif; other site 1037911001793 Walker B; other site 1037911001794 D-loop; other site 1037911001795 H-loop/switch region; other site 1037911001796 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1037911001797 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1037911001798 Walker A/P-loop; other site 1037911001799 ATP binding site [chemical binding]; other site 1037911001800 Q-loop/lid; other site 1037911001801 ABC transporter signature motif; other site 1037911001802 Walker B; other site 1037911001803 D-loop; other site 1037911001804 H-loop/switch region; other site 1037911001805 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1037911001806 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1037911001807 putative NAD(P) binding site [chemical binding]; other site 1037911001808 homotetramer interface [polypeptide binding]; other site 1037911001809 homodimer interface [polypeptide binding]; other site 1037911001810 active site 1037911001811 Cation efflux family; Region: Cation_efflux; cl00316 1037911001812 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1037911001813 putative active cleft [active] 1037911001814 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1037911001815 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1037911001816 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1037911001817 UreF; Region: UreF; pfam01730 1037911001818 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1037911001819 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1037911001820 dimer interface [polypeptide binding]; other site 1037911001821 catalytic residues [active] 1037911001822 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1037911001823 NlpC/P60 family; Region: NLPC_P60; pfam00877 1037911001824 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1037911001825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911001826 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1037911001827 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1037911001828 Ferritin-like domain; Region: Ferritin; pfam00210 1037911001829 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1037911001830 dinuclear metal binding motif [ion binding]; other site 1037911001831 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1037911001832 EamA-like transporter family; Region: EamA; pfam00892 1037911001833 EamA-like transporter family; Region: EamA; pfam00892 1037911001834 Helix-turn-helix domain; Region: HTH_18; pfam12833 1037911001835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911001836 hypothetical protein; Provisional; Region: PRK11505 1037911001837 psiF repeat; Region: PsiF_repeat; pfam07769 1037911001838 psiF repeat; Region: PsiF_repeat; pfam07769 1037911001839 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1037911001840 putative chaperone; Provisional; Region: PRK11678 1037911001841 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1037911001842 nucleotide binding site [chemical binding]; other site 1037911001843 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1037911001844 SBD interface [polypeptide binding]; other site 1037911001845 Leucine rich repeat; Region: LRR_8; pfam13855 1037911001846 Leucine rich repeat; Region: LRR_8; pfam13855 1037911001847 SET domain; Region: SET; pfam00856 1037911001848 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1037911001849 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1037911001850 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1037911001851 substrate binding site [polypeptide binding]; other site 1037911001852 dimer interface [polypeptide binding]; other site 1037911001853 Leucine rich repeat; Region: LRR_8; pfam13855 1037911001854 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1037911001855 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1037911001856 subunit interactions [polypeptide binding]; other site 1037911001857 active site 1037911001858 flap region; other site 1037911001859 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1037911001860 gamma-beta subunit interface [polypeptide binding]; other site 1037911001861 alpha-beta subunit interface [polypeptide binding]; other site 1037911001862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911001863 Coenzyme A binding pocket [chemical binding]; other site 1037911001864 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1037911001865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911001866 Coenzyme A binding pocket [chemical binding]; other site 1037911001867 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1037911001868 alpha-gamma subunit interface [polypeptide binding]; other site 1037911001869 beta-gamma subunit interface [polypeptide binding]; other site 1037911001870 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1037911001871 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1037911001872 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1037911001873 Walker A/P-loop; other site 1037911001874 ATP binding site [chemical binding]; other site 1037911001875 Q-loop/lid; other site 1037911001876 ABC transporter signature motif; other site 1037911001877 Walker B; other site 1037911001878 D-loop; other site 1037911001879 H-loop/switch region; other site 1037911001880 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1037911001881 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1037911001882 Walker A/P-loop; other site 1037911001883 ATP binding site [chemical binding]; other site 1037911001884 Q-loop/lid; other site 1037911001885 ABC transporter signature motif; other site 1037911001886 Walker B; other site 1037911001887 D-loop; other site 1037911001888 H-loop/switch region; other site 1037911001889 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1037911001890 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1037911001891 TM-ABC transporter signature motif; other site 1037911001892 HEAT repeats; Region: HEAT_2; pfam13646 1037911001893 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1037911001894 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911001895 TM-ABC transporter signature motif; other site 1037911001896 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1037911001897 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1037911001898 putative ligand binding site [chemical binding]; other site 1037911001899 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1037911001900 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1037911001901 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1037911001902 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1037911001903 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911001904 N-terminal plug; other site 1037911001905 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1037911001906 ligand-binding site [chemical binding]; other site 1037911001907 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1037911001908 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1037911001909 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1037911001910 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1037911001911 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1037911001912 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1037911001913 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1037911001914 active site 1037911001915 putative homodimer interface [polypeptide binding]; other site 1037911001916 SAM binding site [chemical binding]; other site 1037911001917 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1037911001918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911001919 S-adenosylmethionine binding site [chemical binding]; other site 1037911001920 precorrin-3B synthase; Region: CobG; TIGR02435 1037911001921 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1037911001922 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1037911001923 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1037911001924 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1037911001925 active site 1037911001926 SAM binding site [chemical binding]; other site 1037911001927 homodimer interface [polypeptide binding]; other site 1037911001928 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1037911001929 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1037911001930 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1037911001931 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1037911001932 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1037911001933 active site 1037911001934 SAM binding site [chemical binding]; other site 1037911001935 homodimer interface [polypeptide binding]; other site 1037911001936 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1037911001937 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1037911001938 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1037911001939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911001940 dimer interface [polypeptide binding]; other site 1037911001941 phosphorylation site [posttranslational modification] 1037911001942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911001943 ATP binding site [chemical binding]; other site 1037911001944 Mg2+ binding site [ion binding]; other site 1037911001945 G-X-G motif; other site 1037911001946 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911001947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911001948 active site 1037911001949 phosphorylation site [posttranslational modification] 1037911001950 intermolecular recognition site; other site 1037911001951 dimerization interface [polypeptide binding]; other site 1037911001952 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911001953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911001954 active site 1037911001955 phosphorylation site [posttranslational modification] 1037911001956 intermolecular recognition site; other site 1037911001957 dimerization interface [polypeptide binding]; other site 1037911001958 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1037911001959 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1037911001960 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1037911001961 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1037911001962 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1037911001963 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1037911001964 purine monophosphate binding site [chemical binding]; other site 1037911001965 dimer interface [polypeptide binding]; other site 1037911001966 putative catalytic residues [active] 1037911001967 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1037911001968 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1037911001969 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1037911001970 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1037911001971 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1037911001972 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1037911001973 FMN binding site [chemical binding]; other site 1037911001974 active site 1037911001975 catalytic residues [active] 1037911001976 substrate binding site [chemical binding]; other site 1037911001977 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1037911001978 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1037911001979 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1037911001980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911001981 S-adenosylmethionine binding site [chemical binding]; other site 1037911001982 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1037911001983 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1037911001984 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1037911001985 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1037911001986 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1037911001987 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1037911001988 carboxyltransferase (CT) interaction site; other site 1037911001989 biotinylation site [posttranslational modification]; other site 1037911001990 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1037911001991 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1037911001992 active site 1037911001993 trimer interface [polypeptide binding]; other site 1037911001994 dimer interface [polypeptide binding]; other site 1037911001995 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911001996 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911001997 dimer interface [polypeptide binding]; other site 1037911001998 putative CheW interface [polypeptide binding]; other site 1037911001999 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1037911002000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911002001 active site 1037911002002 phosphorylation site [posttranslational modification] 1037911002003 intermolecular recognition site; other site 1037911002004 dimerization interface [polypeptide binding]; other site 1037911002005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911002006 metal binding site [ion binding]; metal-binding site 1037911002007 active site 1037911002008 I-site; other site 1037911002009 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1037911002010 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1037911002011 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1037911002012 nudix motif; other site 1037911002013 translation initiation factor Sui1; Validated; Region: PRK06824 1037911002014 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1037911002015 putative rRNA binding site [nucleotide binding]; other site 1037911002016 arginine decarboxylase; Provisional; Region: PRK05354 1037911002017 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1037911002018 dimer interface [polypeptide binding]; other site 1037911002019 active site 1037911002020 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1037911002021 catalytic residues [active] 1037911002022 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1037911002023 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1037911002024 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1037911002025 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1037911002026 MG2 domain; Region: A2M_N; pfam01835 1037911002027 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1037911002028 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1037911002029 surface patch; other site 1037911002030 thioester region; other site 1037911002031 specificity defining residues; other site 1037911002032 penicillin-binding protein 1C; Provisional; Region: PRK11240 1037911002033 Transglycosylase; Region: Transgly; pfam00912 1037911002034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1037911002035 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1037911002036 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1037911002037 homodimer interface [polypeptide binding]; other site 1037911002038 chemical substrate binding site [chemical binding]; other site 1037911002039 oligomer interface [polypeptide binding]; other site 1037911002040 metal binding site [ion binding]; metal-binding site 1037911002041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911002042 S-adenosylmethionine binding site [chemical binding]; other site 1037911002043 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1037911002044 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1037911002045 Predicted membrane protein [Function unknown]; Region: COG4655 1037911002046 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911002047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911002048 putative active site [active] 1037911002049 heme pocket [chemical binding]; other site 1037911002050 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1037911002051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911002052 putative active site [active] 1037911002053 heme pocket [chemical binding]; other site 1037911002054 PAS domain; Region: PAS; smart00091 1037911002055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911002056 dimer interface [polypeptide binding]; other site 1037911002057 phosphorylation site [posttranslational modification] 1037911002058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911002059 ATP binding site [chemical binding]; other site 1037911002060 Mg2+ binding site [ion binding]; other site 1037911002061 G-X-G motif; other site 1037911002062 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1037911002063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911002064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911002065 active site 1037911002066 phosphorylation site [posttranslational modification] 1037911002067 intermolecular recognition site; other site 1037911002068 dimerization interface [polypeptide binding]; other site 1037911002069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911002070 DNA binding residues [nucleotide binding] 1037911002071 dimerization interface [polypeptide binding]; other site 1037911002072 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1037911002073 TPR repeat; Region: TPR_11; pfam13414 1037911002074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911002075 binding surface 1037911002076 TPR motif; other site 1037911002077 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1037911002078 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1037911002079 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1037911002080 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1037911002081 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1037911002082 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1037911002083 ATP binding site [chemical binding]; other site 1037911002084 Walker A motif; other site 1037911002085 hexamer interface [polypeptide binding]; other site 1037911002086 Walker B motif; other site 1037911002087 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1037911002088 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1037911002089 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1037911002090 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1037911002091 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1037911002092 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1037911002093 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1037911002094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911002095 active site 1037911002096 phosphorylation site [posttranslational modification] 1037911002097 intermolecular recognition site; other site 1037911002098 dimerization interface [polypeptide binding]; other site 1037911002099 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1037911002100 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1037911002101 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1037911002102 active site 2 [active] 1037911002103 active site 1 [active] 1037911002104 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1037911002105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911002106 NAD(P) binding site [chemical binding]; other site 1037911002107 active site 1037911002108 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1037911002109 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1037911002110 dimer interface [polypeptide binding]; other site 1037911002111 active site 1037911002112 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 1037911002113 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1037911002114 ATP binding site [chemical binding]; other site 1037911002115 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1037911002116 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1037911002117 DNA binding residues [nucleotide binding] 1037911002118 dimer interface [polypeptide binding]; other site 1037911002119 copper binding site [ion binding]; other site 1037911002120 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1037911002121 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1037911002122 metal-binding site [ion binding] 1037911002123 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1037911002124 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1037911002125 metal-binding site [ion binding] 1037911002126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911002127 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1037911002128 putative substrate translocation pore; other site 1037911002129 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1037911002130 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1037911002131 putative NAD(P) binding site [chemical binding]; other site 1037911002132 dimer interface [polypeptide binding]; other site 1037911002133 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1037911002134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911002135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911002136 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911002137 putative effector binding pocket; other site 1037911002138 dimerization interface [polypeptide binding]; other site 1037911002139 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 1037911002140 benzoate transport; Region: 2A0115; TIGR00895 1037911002141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911002142 putative substrate translocation pore; other site 1037911002143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911002144 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1037911002145 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1037911002146 active site 1037911002147 purine riboside binding site [chemical binding]; other site 1037911002148 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1037911002149 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1037911002150 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1037911002151 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1037911002152 active site 1037911002153 putative substrate binding pocket [chemical binding]; other site 1037911002154 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1037911002155 short chain dehydrogenase; Provisional; Region: PRK08177 1037911002156 NAD(P) binding site [chemical binding]; other site 1037911002157 active site 1037911002158 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1037911002159 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1037911002160 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1037911002161 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1037911002162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911002163 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1037911002164 xanthine permease; Region: pbuX; TIGR03173 1037911002165 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1037911002166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911002167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911002168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911002169 dimerization interface [polypeptide binding]; other site 1037911002170 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1037911002171 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911002172 inhibitor-cofactor binding pocket; inhibition site 1037911002173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911002174 catalytic residue [active] 1037911002175 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1037911002176 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1037911002177 tetrameric interface [polypeptide binding]; other site 1037911002178 NAD binding site [chemical binding]; other site 1037911002179 catalytic residues [active] 1037911002180 Paraquat-inducible protein A; Region: PqiA; pfam04403 1037911002181 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1037911002182 Paraquat-inducible protein A; Region: PqiA; pfam04403 1037911002183 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1037911002184 mce related protein; Region: MCE; pfam02470 1037911002185 mce related protein; Region: MCE; pfam02470 1037911002186 mce related protein; Region: MCE; pfam02470 1037911002187 mce related protein; Region: MCE; pfam02470 1037911002188 mce related protein; Region: MCE; pfam02470 1037911002189 mce related protein; Region: MCE; pfam02470 1037911002190 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1037911002191 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1037911002192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911002193 Coenzyme A binding pocket [chemical binding]; other site 1037911002194 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1037911002195 active site clefts [active] 1037911002196 zinc binding site [ion binding]; other site 1037911002197 dimer interface [polypeptide binding]; other site 1037911002198 Proteins containing SET domain [General function prediction only]; Region: COG2940 1037911002199 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1037911002200 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 1037911002201 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1037911002202 metabolite-proton symporter; Region: 2A0106; TIGR00883 1037911002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911002204 GntP family permease; Region: GntP_permease; pfam02447 1037911002205 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1037911002206 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1037911002207 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1037911002208 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1037911002209 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911002210 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1037911002211 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911002212 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1037911002213 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1037911002214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911002215 dimerization interface [polypeptide binding]; other site 1037911002216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911002217 dimer interface [polypeptide binding]; other site 1037911002218 phosphorylation site [posttranslational modification] 1037911002219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911002220 ATP binding site [chemical binding]; other site 1037911002221 Mg2+ binding site [ion binding]; other site 1037911002222 G-X-G motif; other site 1037911002223 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1037911002224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911002225 active site 1037911002226 phosphorylation site [posttranslational modification] 1037911002227 intermolecular recognition site; other site 1037911002228 dimerization interface [polypeptide binding]; other site 1037911002229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911002230 DNA binding site [nucleotide binding] 1037911002231 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911002232 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1037911002233 PAS domain; Region: PAS_9; pfam13426 1037911002234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911002235 putative active site [active] 1037911002236 heme pocket [chemical binding]; other site 1037911002237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911002238 PAS domain; Region: PAS_9; pfam13426 1037911002239 putative active site [active] 1037911002240 heme pocket [chemical binding]; other site 1037911002241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911002242 dimer interface [polypeptide binding]; other site 1037911002243 putative CheW interface [polypeptide binding]; other site 1037911002244 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1037911002245 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911002246 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911002247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911002248 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1037911002249 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1037911002250 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1037911002251 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1037911002252 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1037911002253 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1037911002254 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1037911002255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911002256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911002257 DNA binding residues [nucleotide binding] 1037911002258 HrpJ-like domain; Region: HrpJ; cl15454 1037911002259 TyeA; Region: TyeA; cl07611 1037911002260 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1037911002261 FHIPEP family; Region: FHIPEP; pfam00771 1037911002262 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1037911002263 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1037911002264 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1037911002265 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1037911002266 Walker A motif; other site 1037911002267 ATP binding site [chemical binding]; other site 1037911002268 Walker B motif; other site 1037911002269 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1037911002270 type III secretion system protein; Validated; Region: PRK06933 1037911002271 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1037911002272 type III secretion system protein YscR; Provisional; Region: PRK12797 1037911002273 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 1037911002274 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1037911002275 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 1037911002276 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1037911002277 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1037911002278 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1037911002279 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1037911002280 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 1037911002281 Flagellar assembly protein FliH; Region: FliH; pfam02108 1037911002282 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1037911002283 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1037911002284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911002285 Walker A motif; other site 1037911002286 ATP binding site [chemical binding]; other site 1037911002287 Walker B motif; other site 1037911002288 arginine finger; other site 1037911002289 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911002290 GTP-binding protein YchF; Reviewed; Region: PRK09601 1037911002291 YchF GTPase; Region: YchF; cd01900 1037911002292 G1 box; other site 1037911002293 GTP/Mg2+ binding site [chemical binding]; other site 1037911002294 Switch I region; other site 1037911002295 G2 box; other site 1037911002296 Switch II region; other site 1037911002297 G3 box; other site 1037911002298 G4 box; other site 1037911002299 G5 box; other site 1037911002300 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1037911002301 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1037911002302 putative active site [active] 1037911002303 catalytic residue [active] 1037911002304 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1037911002305 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1037911002306 5S rRNA interface [nucleotide binding]; other site 1037911002307 CTC domain interface [polypeptide binding]; other site 1037911002308 L16 interface [polypeptide binding]; other site 1037911002309 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1037911002310 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1037911002311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911002312 active site 1037911002313 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1037911002314 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1037911002315 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1037911002316 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1037911002317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911002318 binding surface 1037911002319 TPR motif; other site 1037911002320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911002321 binding surface 1037911002322 TPR motif; other site 1037911002323 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1037911002324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911002325 binding surface 1037911002326 TPR motif; other site 1037911002327 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1037911002328 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1037911002329 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1037911002330 tRNA; other site 1037911002331 putative tRNA binding site [nucleotide binding]; other site 1037911002332 putative NADP binding site [chemical binding]; other site 1037911002333 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1037911002334 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1037911002335 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1037911002336 RF-1 domain; Region: RF-1; pfam00472 1037911002337 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1037911002338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911002339 S-adenosylmethionine binding site [chemical binding]; other site 1037911002340 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1037911002341 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1037911002342 ATP binding site [chemical binding]; other site 1037911002343 substrate interface [chemical binding]; other site 1037911002344 glutamate racemase; Provisional; Region: PRK00865 1037911002345 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1037911002346 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1037911002347 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1037911002348 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1037911002349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911002350 S-adenosylmethionine binding site [chemical binding]; other site 1037911002351 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1037911002352 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1037911002353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911002354 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1037911002355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911002356 short chain dehydrogenase; Provisional; Region: PRK06101 1037911002357 NAD(P) binding site [chemical binding]; other site 1037911002358 active site 1037911002359 SnoaL-like domain; Region: SnoaL_2; pfam12680 1037911002360 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1037911002361 DNA photolyase; Region: DNA_photolyase; pfam00875 1037911002362 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1037911002363 DNA binding residues [nucleotide binding] 1037911002364 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1037911002365 B12 binding domain; Region: B12-binding_2; pfam02607 1037911002366 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1037911002367 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1037911002368 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1037911002369 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 1037911002370 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1037911002371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911002372 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1037911002373 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1037911002374 putative NAD(P) binding site [chemical binding]; other site 1037911002375 putative active site [active] 1037911002376 ferrochelatase; Reviewed; Region: hemH; PRK00035 1037911002377 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1037911002378 C-terminal domain interface [polypeptide binding]; other site 1037911002379 active site 1037911002380 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1037911002381 active site 1037911002382 N-terminal domain interface [polypeptide binding]; other site 1037911002383 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1037911002384 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911002385 N-terminal plug; other site 1037911002386 ligand-binding site [chemical binding]; other site 1037911002387 serine endoprotease; Provisional; Region: PRK10898 1037911002388 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1037911002389 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1037911002390 protein binding site [polypeptide binding]; other site 1037911002391 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1037911002392 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1037911002393 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1037911002394 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1037911002395 Active Sites [active] 1037911002396 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1037911002397 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1037911002398 CysD dimerization site [polypeptide binding]; other site 1037911002399 G1 box; other site 1037911002400 putative GEF interaction site [polypeptide binding]; other site 1037911002401 GTP/Mg2+ binding site [chemical binding]; other site 1037911002402 Switch I region; other site 1037911002403 G2 box; other site 1037911002404 G3 box; other site 1037911002405 Switch II region; other site 1037911002406 G4 box; other site 1037911002407 G5 box; other site 1037911002408 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1037911002409 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1037911002410 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1037911002411 ligand-binding site [chemical binding]; other site 1037911002412 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1037911002413 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1037911002414 putative acyl-acceptor binding pocket; other site 1037911002415 phosphate acetyltransferase; Reviewed; Region: PRK05632 1037911002416 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1037911002417 DRTGG domain; Region: DRTGG; pfam07085 1037911002418 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1037911002419 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1037911002420 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1037911002421 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1037911002422 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1037911002423 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1037911002424 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1037911002425 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1037911002426 active site 1037911002427 Riboflavin kinase; Region: Flavokinase; pfam01687 1037911002428 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1037911002429 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1037911002430 active site 1037911002431 HIGH motif; other site 1037911002432 nucleotide binding site [chemical binding]; other site 1037911002433 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1037911002434 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1037911002435 active site 1037911002436 KMSKS motif; other site 1037911002437 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1037911002438 tRNA binding surface [nucleotide binding]; other site 1037911002439 anticodon binding site; other site 1037911002440 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1037911002441 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1037911002442 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1037911002443 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1037911002444 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1037911002445 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1037911002446 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1037911002447 Type II transport protein GspH; Region: GspH; pfam12019 1037911002448 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1037911002449 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1037911002450 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1037911002451 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1037911002452 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1037911002453 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1037911002454 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1037911002455 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1037911002456 RNA binding surface [nucleotide binding]; other site 1037911002457 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1037911002458 active site 1037911002459 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1037911002460 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1037911002461 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1037911002462 Clp amino terminal domain; Region: Clp_N; pfam02861 1037911002463 Clp amino terminal domain; Region: Clp_N; pfam02861 1037911002464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911002465 Walker A motif; other site 1037911002466 ATP binding site [chemical binding]; other site 1037911002467 Walker B motif; other site 1037911002468 arginine finger; other site 1037911002469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911002470 Walker A motif; other site 1037911002471 ATP binding site [chemical binding]; other site 1037911002472 Walker B motif; other site 1037911002473 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1037911002474 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1037911002475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911002476 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1037911002477 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 1037911002478 Predicted membrane protein [Function unknown]; Region: COG3235 1037911002479 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1037911002480 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1037911002481 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1037911002482 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1037911002483 CoA-binding site [chemical binding]; other site 1037911002484 ATP-binding [chemical binding]; other site 1037911002485 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1037911002486 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1037911002487 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1037911002488 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1037911002489 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1037911002490 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1037911002491 Pilin (bacterial filament); Region: Pilin; pfam00114 1037911002492 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1037911002493 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1037911002494 dimerization interface [polypeptide binding]; other site 1037911002495 active site 1037911002496 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1037911002497 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1037911002498 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1037911002499 amidase catalytic site [active] 1037911002500 Zn binding residues [ion binding]; other site 1037911002501 substrate binding site [chemical binding]; other site 1037911002502 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1037911002503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911002504 dimerization interface [polypeptide binding]; other site 1037911002505 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911002506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911002507 dimer interface [polypeptide binding]; other site 1037911002508 putative CheW interface [polypeptide binding]; other site 1037911002509 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1037911002510 active site 1037911002511 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1037911002512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1037911002513 DNA binding site [nucleotide binding] 1037911002514 domain linker motif; other site 1037911002515 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1037911002516 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1037911002517 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1037911002518 active site 1037911002519 phosphorylation site [posttranslational modification] 1037911002520 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1037911002521 active site 1037911002522 phosphorylation site [posttranslational modification] 1037911002523 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1037911002524 dimerization domain swap beta strand [polypeptide binding]; other site 1037911002525 regulatory protein interface [polypeptide binding]; other site 1037911002526 active site 1037911002527 regulatory phosphorylation site [posttranslational modification]; other site 1037911002528 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1037911002529 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1037911002530 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1037911002531 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1037911002532 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1037911002533 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1037911002534 putative substrate binding site [chemical binding]; other site 1037911002535 putative ATP binding site [chemical binding]; other site 1037911002536 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1037911002537 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1037911002538 active site 1037911002539 P-loop; other site 1037911002540 phosphorylation site [posttranslational modification] 1037911002541 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1037911002542 active site 1037911002543 P-loop; other site 1037911002544 phosphorylation site [posttranslational modification] 1037911002545 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1037911002546 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1037911002547 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1037911002548 putative active site [active] 1037911002549 putative metal binding site [ion binding]; other site 1037911002550 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1037911002551 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1037911002552 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1037911002553 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1037911002554 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1037911002555 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1037911002556 Flavodoxin; Region: Flavodoxin_1; pfam00258 1037911002557 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1037911002558 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1037911002559 FAD binding pocket [chemical binding]; other site 1037911002560 FAD binding motif [chemical binding]; other site 1037911002561 catalytic residues [active] 1037911002562 NAD binding pocket [chemical binding]; other site 1037911002563 phosphate binding motif [ion binding]; other site 1037911002564 beta-alpha-beta structure motif; other site 1037911002565 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1037911002566 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911002567 N-terminal plug; other site 1037911002568 ligand-binding site [chemical binding]; other site 1037911002569 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1037911002570 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1037911002571 Sel1-like repeats; Region: SEL1; smart00671 1037911002572 Sel1-like repeats; Region: SEL1; smart00671 1037911002573 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1037911002574 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1037911002575 dimer interface [polypeptide binding]; other site 1037911002576 active site 1037911002577 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1037911002578 catalytic residues [active] 1037911002579 substrate binding site [chemical binding]; other site 1037911002580 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1037911002581 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1037911002582 Walker A/P-loop; other site 1037911002583 ATP binding site [chemical binding]; other site 1037911002584 Q-loop/lid; other site 1037911002585 ABC transporter signature motif; other site 1037911002586 Walker B; other site 1037911002587 D-loop; other site 1037911002588 H-loop/switch region; other site 1037911002589 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1037911002590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911002591 dimer interface [polypeptide binding]; other site 1037911002592 conserved gate region; other site 1037911002593 ABC-ATPase subunit interface; other site 1037911002594 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1037911002595 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1037911002596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911002597 dimer interface [polypeptide binding]; other site 1037911002598 conserved gate region; other site 1037911002599 putative PBP binding loops; other site 1037911002600 ABC-ATPase subunit interface; other site 1037911002601 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1037911002602 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1037911002603 G1 box; other site 1037911002604 putative GEF interaction site [polypeptide binding]; other site 1037911002605 GTP/Mg2+ binding site [chemical binding]; other site 1037911002606 Switch I region; other site 1037911002607 G2 box; other site 1037911002608 G3 box; other site 1037911002609 Switch II region; other site 1037911002610 G4 box; other site 1037911002611 G5 box; other site 1037911002612 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1037911002613 outer membrane receptor FepA; Provisional; Region: PRK13524 1037911002614 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911002615 N-terminal plug; other site 1037911002616 ligand-binding site [chemical binding]; other site 1037911002617 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1037911002618 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1037911002619 Walker A/P-loop; other site 1037911002620 ATP binding site [chemical binding]; other site 1037911002621 Q-loop/lid; other site 1037911002622 ABC transporter signature motif; other site 1037911002623 Walker B; other site 1037911002624 D-loop; other site 1037911002625 H-loop/switch region; other site 1037911002626 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1037911002627 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1037911002628 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1037911002629 Walker A/P-loop; other site 1037911002630 ATP binding site [chemical binding]; other site 1037911002631 Q-loop/lid; other site 1037911002632 ABC transporter signature motif; other site 1037911002633 Walker B; other site 1037911002634 D-loop; other site 1037911002635 H-loop/switch region; other site 1037911002636 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1037911002637 dipeptide transporter; Provisional; Region: PRK10913 1037911002638 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1037911002639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911002640 dimer interface [polypeptide binding]; other site 1037911002641 conserved gate region; other site 1037911002642 putative PBP binding loops; other site 1037911002643 ABC-ATPase subunit interface; other site 1037911002644 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1037911002645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911002646 dimer interface [polypeptide binding]; other site 1037911002647 conserved gate region; other site 1037911002648 putative PBP binding loops; other site 1037911002649 ABC-ATPase subunit interface; other site 1037911002650 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1037911002651 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1037911002652 peptide binding site [polypeptide binding]; other site 1037911002653 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911002654 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1037911002655 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1037911002656 peptide binding site [polypeptide binding]; other site 1037911002657 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1037911002658 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1037911002659 peptide binding site [polypeptide binding]; other site 1037911002660 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1037911002661 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1037911002662 peptide binding site [polypeptide binding]; other site 1037911002663 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1037911002664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911002665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911002666 ATP binding site [chemical binding]; other site 1037911002667 G-X-G motif; other site 1037911002668 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1037911002669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911002670 active site 1037911002671 phosphorylation site [posttranslational modification] 1037911002672 intermolecular recognition site; other site 1037911002673 dimerization interface [polypeptide binding]; other site 1037911002674 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911002675 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1037911002676 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1037911002677 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1037911002678 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1037911002679 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1037911002680 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1037911002681 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1037911002682 active site 1037911002683 HIGH motif; other site 1037911002684 dimer interface [polypeptide binding]; other site 1037911002685 KMSKS motif; other site 1037911002686 Predicted ATPase [General function prediction only]; Region: COG1485 1037911002687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1037911002688 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911002689 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1037911002690 conserved cys residue [active] 1037911002691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911002692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911002693 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911002694 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911002695 active site 1037911002696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1037911002697 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1037911002698 active site 1037911002699 catalytic tetrad [active] 1037911002700 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1037911002701 23S rRNA interface [nucleotide binding]; other site 1037911002702 L3 interface [polypeptide binding]; other site 1037911002703 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1037911002704 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1037911002705 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1037911002706 [2Fe-2S] cluster binding site [ion binding]; other site 1037911002707 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1037911002708 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1037911002709 Qi binding site; other site 1037911002710 intrachain domain interface; other site 1037911002711 interchain domain interface [polypeptide binding]; other site 1037911002712 heme bH binding site [chemical binding]; other site 1037911002713 heme bL binding site [chemical binding]; other site 1037911002714 Qo binding site; other site 1037911002715 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1037911002716 interchain domain interface [polypeptide binding]; other site 1037911002717 intrachain domain interface; other site 1037911002718 Qi binding site; other site 1037911002719 Qo binding site; other site 1037911002720 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1037911002721 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1037911002722 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1037911002723 C-terminal domain interface [polypeptide binding]; other site 1037911002724 putative GSH binding site (G-site) [chemical binding]; other site 1037911002725 dimer interface [polypeptide binding]; other site 1037911002726 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1037911002727 dimer interface [polypeptide binding]; other site 1037911002728 N-terminal domain interface [polypeptide binding]; other site 1037911002729 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1037911002730 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911002731 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911002732 DNA-binding site [nucleotide binding]; DNA binding site 1037911002733 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1037911002734 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1037911002735 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1037911002736 putative active site [active] 1037911002737 catalytic residue [active] 1037911002738 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1037911002739 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1037911002740 NAD(P) binding site [chemical binding]; other site 1037911002741 catalytic residues [active] 1037911002742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911002743 D-galactonate transporter; Region: 2A0114; TIGR00893 1037911002744 putative substrate translocation pore; other site 1037911002745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911002746 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1037911002747 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1037911002748 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1037911002749 Predicted permeases [General function prediction only]; Region: COG0679 1037911002750 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1037911002751 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1037911002752 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1037911002753 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1037911002754 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1037911002755 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1037911002756 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1037911002757 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1037911002758 GatB domain; Region: GatB_Yqey; smart00845 1037911002759 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1037911002760 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1037911002761 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1037911002762 rod shape-determining protein MreB; Provisional; Region: PRK13927 1037911002763 MreB and similar proteins; Region: MreB_like; cd10225 1037911002764 nucleotide binding site [chemical binding]; other site 1037911002765 Mg binding site [ion binding]; other site 1037911002766 putative protofilament interaction site [polypeptide binding]; other site 1037911002767 RodZ interaction site [polypeptide binding]; other site 1037911002768 rod shape-determining protein MreC; Provisional; Region: PRK13922 1037911002769 rod shape-determining protein MreC; Region: MreC; pfam04085 1037911002770 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1037911002771 Maf-like protein; Region: Maf; pfam02545 1037911002772 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1037911002773 active site 1037911002774 dimer interface [polypeptide binding]; other site 1037911002775 ribonuclease G; Provisional; Region: PRK11712 1037911002776 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1037911002777 homodimer interface [polypeptide binding]; other site 1037911002778 oligonucleotide binding site [chemical binding]; other site 1037911002779 TIGR02099 family protein; Region: TIGR02099 1037911002780 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1037911002781 nitrilase; Region: PLN02798 1037911002782 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1037911002783 putative active site [active] 1037911002784 catalytic triad [active] 1037911002785 dimer interface [polypeptide binding]; other site 1037911002786 protease TldD; Provisional; Region: tldD; PRK10735 1037911002787 hypothetical protein; Provisional; Region: PRK05255 1037911002788 peptidase PmbA; Provisional; Region: PRK11040 1037911002789 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1037911002790 Class II fumarases; Region: Fumarase_classII; cd01362 1037911002791 active site 1037911002792 tetramer interface [polypeptide binding]; other site 1037911002793 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1037911002794 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1037911002795 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1037911002796 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1037911002797 ZIP Zinc transporter; Region: Zip; pfam02535 1037911002798 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1037911002799 dimerization domain swap beta strand [polypeptide binding]; other site 1037911002800 regulatory protein interface [polypeptide binding]; other site 1037911002801 active site 1037911002802 regulatory phosphorylation site [posttranslational modification]; other site 1037911002803 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1037911002804 AAA domain; Region: AAA_18; pfam13238 1037911002805 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1037911002806 active site 1037911002807 phosphorylation site [posttranslational modification] 1037911002808 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1037911002809 30S subunit binding site; other site 1037911002810 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1037911002811 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1037911002812 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1037911002813 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1037911002814 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1037911002815 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1037911002816 Walker A/P-loop; other site 1037911002817 ATP binding site [chemical binding]; other site 1037911002818 Q-loop/lid; other site 1037911002819 ABC transporter signature motif; other site 1037911002820 Walker B; other site 1037911002821 D-loop; other site 1037911002822 H-loop/switch region; other site 1037911002823 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1037911002824 OstA-like protein; Region: OstA; pfam03968 1037911002825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1037911002826 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1037911002827 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1037911002828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911002829 active site 1037911002830 motif I; other site 1037911002831 motif II; other site 1037911002832 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1037911002833 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1037911002834 putative active site [active] 1037911002835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1037911002836 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1037911002837 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1037911002838 Walker A/P-loop; other site 1037911002839 ATP binding site [chemical binding]; other site 1037911002840 Q-loop/lid; other site 1037911002841 ABC transporter signature motif; other site 1037911002842 Walker B; other site 1037911002843 D-loop; other site 1037911002844 H-loop/switch region; other site 1037911002845 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1037911002846 Permease; Region: Permease; cl00510 1037911002847 mce related protein; Region: MCE; pfam02470 1037911002848 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1037911002849 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1037911002850 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1037911002851 anti sigma factor interaction site; other site 1037911002852 regulatory phosphorylation site [posttranslational modification]; other site 1037911002853 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1037911002854 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1037911002855 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1037911002856 hinge; other site 1037911002857 active site 1037911002858 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1037911002859 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1037911002860 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1037911002861 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1037911002862 NAD binding site [chemical binding]; other site 1037911002863 dimerization interface [polypeptide binding]; other site 1037911002864 product binding site; other site 1037911002865 substrate binding site [chemical binding]; other site 1037911002866 zinc binding site [ion binding]; other site 1037911002867 catalytic residues [active] 1037911002868 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1037911002869 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911002870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911002871 homodimer interface [polypeptide binding]; other site 1037911002872 catalytic residue [active] 1037911002873 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1037911002874 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911002875 active site 1037911002876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911002877 active site 1037911002878 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1037911002879 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1037911002880 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1037911002881 hypothetical protein; Provisional; Region: PRK11627 1037911002882 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1037911002883 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1037911002884 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1037911002885 putative acyl-acceptor binding pocket; other site 1037911002886 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1037911002887 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1037911002888 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1037911002889 Peptidase family M48; Region: Peptidase_M48; pfam01435 1037911002890 Predicted membrane protein [Function unknown]; Region: COG2119 1037911002891 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1037911002892 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1037911002893 yybP-ykoY leader 1037911002894 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1037911002895 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1037911002896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911002897 S-adenosylmethionine binding site [chemical binding]; other site 1037911002898 glycerate dehydrogenase; Provisional; Region: PRK06487 1037911002899 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1037911002900 putative ligand binding site [chemical binding]; other site 1037911002901 putative NAD binding site [chemical binding]; other site 1037911002902 catalytic site [active] 1037911002903 LysE type translocator; Region: LysE; cl00565 1037911002904 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1037911002905 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1037911002906 acyl-activating enzyme (AAE) consensus motif; other site 1037911002907 AMP binding site [chemical binding]; other site 1037911002908 active site 1037911002909 CoA binding site [chemical binding]; other site 1037911002910 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1037911002911 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1037911002912 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1037911002913 AAA ATPase domain; Region: AAA_16; pfam13191 1037911002914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911002915 DNA binding residues [nucleotide binding] 1037911002916 dimerization interface [polypeptide binding]; other site 1037911002917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1037911002918 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1037911002919 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1037911002920 mce related protein; Region: MCE; pfam02470 1037911002921 mce related protein; Region: MCE; pfam02470 1037911002922 mce related protein; Region: MCE; pfam02470 1037911002923 Paraquat-inducible protein A; Region: PqiA; pfam04403 1037911002924 Paraquat-inducible protein A; Region: PqiA; pfam04403 1037911002925 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1037911002926 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1037911002927 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911002928 ligand binding site [chemical binding]; other site 1037911002929 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1037911002930 BON domain; Region: BON; pfam04972 1037911002931 BON domain; Region: BON; pfam04972 1037911002932 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1037911002933 dimer interface [polypeptide binding]; other site 1037911002934 active site 1037911002935 hypothetical protein; Reviewed; Region: PRK12497 1037911002936 LppC putative lipoprotein; Region: LppC; pfam04348 1037911002937 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1037911002938 putative ligand binding site [chemical binding]; other site 1037911002939 Predicted methyltransferases [General function prediction only]; Region: COG0313 1037911002940 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1037911002941 putative SAM binding site [chemical binding]; other site 1037911002942 putative homodimer interface [polypeptide binding]; other site 1037911002943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1037911002944 MraZ protein; Region: MraZ; pfam02381 1037911002945 MraZ protein; Region: MraZ; pfam02381 1037911002946 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1037911002947 MraW methylase family; Region: Methyltransf_5; cl17771 1037911002948 Cell division protein FtsL; Region: FtsL; pfam04999 1037911002949 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1037911002950 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1037911002951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1037911002952 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1037911002953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1037911002954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1037911002955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1037911002956 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1037911002957 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1037911002958 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1037911002959 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1037911002960 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1037911002961 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1037911002962 Mg++ binding site [ion binding]; other site 1037911002963 putative catalytic motif [active] 1037911002964 putative substrate binding site [chemical binding]; other site 1037911002965 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1037911002966 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1037911002967 cell division protein FtsW; Region: ftsW; TIGR02614 1037911002968 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1037911002969 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1037911002970 active site 1037911002971 homodimer interface [polypeptide binding]; other site 1037911002972 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1037911002973 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1037911002974 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1037911002975 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1037911002976 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1037911002977 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1037911002978 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1037911002979 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1037911002980 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1037911002981 Cell division protein FtsQ; Region: FtsQ; pfam03799 1037911002982 cell division protein FtsA; Region: ftsA; TIGR01174 1037911002983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1037911002984 nucleotide binding site [chemical binding]; other site 1037911002985 Cell division protein FtsA; Region: FtsA; pfam14450 1037911002986 cell division protein FtsZ; Validated; Region: PRK09330 1037911002987 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1037911002988 nucleotide binding site [chemical binding]; other site 1037911002989 SulA interaction site; other site 1037911002990 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1037911002991 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1037911002992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911002993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911002994 metal binding site [ion binding]; metal-binding site 1037911002995 active site 1037911002996 I-site; other site 1037911002997 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911002998 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1037911002999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911003000 dimer interface [polypeptide binding]; other site 1037911003001 phosphorylation site [posttranslational modification] 1037911003002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911003003 ATP binding site [chemical binding]; other site 1037911003004 Mg2+ binding site [ion binding]; other site 1037911003005 G-X-G motif; other site 1037911003006 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1037911003007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003008 active site 1037911003009 phosphorylation site [posttranslational modification] 1037911003010 intermolecular recognition site; other site 1037911003011 dimerization interface [polypeptide binding]; other site 1037911003012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911003013 DNA binding site [nucleotide binding] 1037911003014 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1037911003015 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911003016 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911003017 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911003018 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911003019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911003020 substrate binding pocket [chemical binding]; other site 1037911003021 membrane-bound complex binding site; other site 1037911003022 hinge residues; other site 1037911003023 Flagellin N-methylase; Region: FliB; pfam03692 1037911003024 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1037911003025 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1037911003026 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911003027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003028 active site 1037911003029 phosphorylation site [posttranslational modification] 1037911003030 intermolecular recognition site; other site 1037911003031 dimerization interface [polypeptide binding]; other site 1037911003032 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1037911003033 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1037911003034 dimerization interface [polypeptide binding]; other site 1037911003035 ligand binding site [chemical binding]; other site 1037911003036 NADP binding site [chemical binding]; other site 1037911003037 catalytic site [active] 1037911003038 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911003039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911003040 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911003041 putative effector binding pocket; other site 1037911003042 dimerization interface [polypeptide binding]; other site 1037911003043 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1037911003044 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1037911003045 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1037911003046 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1037911003047 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1037911003048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911003049 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911003050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1037911003051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911003052 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911003053 putative substrate translocation pore; other site 1037911003054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911003055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911003056 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911003057 putative effector binding pocket; other site 1037911003058 dimerization interface [polypeptide binding]; other site 1037911003059 short chain dehydrogenase; Provisional; Region: PRK05693 1037911003060 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1037911003061 NADP binding site [chemical binding]; other site 1037911003062 active site 1037911003063 steroid binding site; other site 1037911003064 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1037911003065 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1037911003066 Substrate binding site; other site 1037911003067 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1037911003068 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1037911003069 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1037911003070 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1037911003071 active site 1037911003072 Right handed beta helix region; Region: Beta_helix; pfam13229 1037911003073 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1037911003074 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1037911003075 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1037911003076 PilZ domain; Region: PilZ; pfam07238 1037911003077 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1037911003078 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911003079 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1037911003080 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1037911003081 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1037911003082 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1037911003083 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1037911003084 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1037911003085 hypothetical protein; Validated; Region: PRK02101 1037911003086 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1037911003087 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1037911003088 NodB motif; other site 1037911003089 active site 1037911003090 catalytic site [active] 1037911003091 metal binding site [ion binding]; metal-binding site 1037911003092 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1037911003093 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1037911003094 putative active site [active] 1037911003095 PhoH-like protein; Region: PhoH; pfam02562 1037911003096 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1037911003097 catalytic triad [active] 1037911003098 putative active site [active] 1037911003099 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1037911003100 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1037911003101 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1037911003102 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1037911003103 trimer interface [polypeptide binding]; other site 1037911003104 dimer interface [polypeptide binding]; other site 1037911003105 putative active site [active] 1037911003106 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1037911003107 MoaE interaction surface [polypeptide binding]; other site 1037911003108 MoeB interaction surface [polypeptide binding]; other site 1037911003109 thiocarboxylated glycine; other site 1037911003110 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1037911003111 MoaE homodimer interface [polypeptide binding]; other site 1037911003112 MoaD interaction [polypeptide binding]; other site 1037911003113 active site residues [active] 1037911003114 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1037911003115 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1037911003116 ATP binding site [chemical binding]; other site 1037911003117 Mg++ binding site [ion binding]; other site 1037911003118 motif III; other site 1037911003119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911003120 nucleotide binding region [chemical binding]; other site 1037911003121 ATP-binding site [chemical binding]; other site 1037911003122 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1037911003123 putative hydrolase; Provisional; Region: PRK11460 1037911003124 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1037911003125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911003126 substrate binding pocket [chemical binding]; other site 1037911003127 membrane-bound complex binding site; other site 1037911003128 hinge residues; other site 1037911003129 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1037911003130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911003131 conserved gate region; other site 1037911003132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911003133 dimer interface [polypeptide binding]; other site 1037911003134 ABC-ATPase subunit interface; other site 1037911003135 putative PBP binding loops; other site 1037911003136 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911003137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911003138 dimer interface [polypeptide binding]; other site 1037911003139 conserved gate region; other site 1037911003140 putative PBP binding loops; other site 1037911003141 ABC-ATPase subunit interface; other site 1037911003142 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1037911003143 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911003144 Walker A/P-loop; other site 1037911003145 ATP binding site [chemical binding]; other site 1037911003146 Q-loop/lid; other site 1037911003147 ABC transporter signature motif; other site 1037911003148 Walker B; other site 1037911003149 D-loop; other site 1037911003150 H-loop/switch region; other site 1037911003151 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1037911003152 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 1037911003153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911003154 non-specific DNA binding site [nucleotide binding]; other site 1037911003155 salt bridge; other site 1037911003156 sequence-specific DNA binding site [nucleotide binding]; other site 1037911003157 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 1037911003158 peptide binding site [polypeptide binding]; other site 1037911003159 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911003160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911003161 DNA-binding site [nucleotide binding]; DNA binding site 1037911003162 FCD domain; Region: FCD; pfam07729 1037911003163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911003164 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1037911003165 hypothetical protein; Provisional; Region: PRK15301 1037911003166 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1037911003167 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1037911003168 PapC N-terminal domain; Region: PapC_N; pfam13954 1037911003169 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1037911003170 PapC C-terminal domain; Region: PapC_C; pfam13953 1037911003171 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1037911003172 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1037911003173 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1037911003174 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1037911003175 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1037911003176 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1037911003177 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1037911003178 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911003179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003180 active site 1037911003181 phosphorylation site [posttranslational modification] 1037911003182 intermolecular recognition site; other site 1037911003183 dimerization interface [polypeptide binding]; other site 1037911003184 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911003185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003186 active site 1037911003187 phosphorylation site [posttranslational modification] 1037911003188 intermolecular recognition site; other site 1037911003189 dimerization interface [polypeptide binding]; other site 1037911003190 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911003191 DNA binding residues [nucleotide binding] 1037911003192 dimerization interface [polypeptide binding]; other site 1037911003193 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1037911003194 SnoaL-like domain; Region: SnoaL_3; pfam13474 1037911003195 SnoaL-like domain; Region: SnoaL_2; pfam12680 1037911003196 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1037911003197 GIY-YIG motif/motif A; other site 1037911003198 putative active site [active] 1037911003199 putative metal binding site [ion binding]; other site 1037911003200 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911003201 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1037911003202 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911003203 N-terminal plug; other site 1037911003204 ligand-binding site [chemical binding]; other site 1037911003205 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1037911003206 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1037911003207 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1037911003208 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1037911003209 Bacterial transcriptional regulator; Region: IclR; pfam01614 1037911003210 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1037911003211 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1037911003212 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1037911003213 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1037911003214 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1037911003215 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1037911003216 C-terminal domain interface [polypeptide binding]; other site 1037911003217 GSH binding site (G-site) [chemical binding]; other site 1037911003218 putative dimer interface [polypeptide binding]; other site 1037911003219 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1037911003220 dimer interface [polypeptide binding]; other site 1037911003221 N-terminal domain interface [polypeptide binding]; other site 1037911003222 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1037911003223 benzoate transport; Region: 2A0115; TIGR00895 1037911003224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911003225 putative substrate translocation pore; other site 1037911003226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911003227 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1037911003228 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1037911003229 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1037911003230 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1037911003231 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1037911003232 NAD binding site [chemical binding]; other site 1037911003233 Phe binding site; other site 1037911003234 YebG protein; Region: YebG; pfam07130 1037911003235 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1037911003236 Predicted membrane protein [Function unknown]; Region: COG3223 1037911003237 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1037911003238 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1037911003239 serine transporter; Region: stp; TIGR00814 1037911003240 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1037911003241 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1037911003242 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1037911003243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911003244 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1037911003245 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1037911003246 dimerization interface [polypeptide binding]; other site 1037911003247 substrate binding pocket [chemical binding]; other site 1037911003248 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1037911003249 30S subunit binding site; other site 1037911003250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911003251 putative substrate translocation pore; other site 1037911003252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911003253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911003254 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1037911003255 putative effector binding pocket; other site 1037911003256 putative dimerization interface [polypeptide binding]; other site 1037911003257 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1037911003258 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911003259 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911003260 N-terminal plug; other site 1037911003261 ligand-binding site [chemical binding]; other site 1037911003262 fec operon regulator FecR; Reviewed; Region: PRK09774 1037911003263 FecR protein; Region: FecR; pfam04773 1037911003264 RNA polymerase sigma factor; Provisional; Region: PRK12528 1037911003265 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911003266 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911003267 DNA binding residues [nucleotide binding] 1037911003268 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1037911003269 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1037911003270 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1037911003271 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1037911003272 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1037911003273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911003274 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911003275 DNA binding residues [nucleotide binding] 1037911003276 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1037911003277 FecR protein; Region: FecR; pfam04773 1037911003278 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911003279 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911003280 N-terminal plug; other site 1037911003281 ligand-binding site [chemical binding]; other site 1037911003282 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1037911003283 catalytic residues [active] 1037911003284 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1037911003285 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1037911003286 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1037911003287 IHF - DNA interface [nucleotide binding]; other site 1037911003288 IHF dimer interface [polypeptide binding]; other site 1037911003289 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1037911003290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911003291 S-adenosylmethionine binding site [chemical binding]; other site 1037911003292 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1037911003293 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1037911003294 HIGH motif; other site 1037911003295 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1037911003296 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1037911003297 active site 1037911003298 KMSKS motif; other site 1037911003299 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1037911003300 tRNA binding surface [nucleotide binding]; other site 1037911003301 anticodon binding site; other site 1037911003302 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1037911003303 DNA polymerase III subunit chi; Validated; Region: PRK05728 1037911003304 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1037911003305 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1037911003306 interface (dimer of trimers) [polypeptide binding]; other site 1037911003307 Substrate-binding/catalytic site; other site 1037911003308 Zn-binding sites [ion binding]; other site 1037911003309 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1037911003310 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1037911003311 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1037911003312 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1037911003313 GTP-binding protein LepA; Provisional; Region: PRK05433 1037911003314 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1037911003315 G1 box; other site 1037911003316 putative GEF interaction site [polypeptide binding]; other site 1037911003317 GTP/Mg2+ binding site [chemical binding]; other site 1037911003318 Switch I region; other site 1037911003319 G2 box; other site 1037911003320 G3 box; other site 1037911003321 Switch II region; other site 1037911003322 G4 box; other site 1037911003323 G5 box; other site 1037911003324 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1037911003325 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1037911003326 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1037911003327 signal peptidase I; Provisional; Region: PRK10861 1037911003328 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1037911003329 Catalytic site [active] 1037911003330 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1037911003331 ribonuclease III; Reviewed; Region: rnc; PRK00102 1037911003332 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1037911003333 dimerization interface [polypeptide binding]; other site 1037911003334 active site 1037911003335 metal binding site [ion binding]; metal-binding site 1037911003336 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1037911003337 dsRNA binding site [nucleotide binding]; other site 1037911003338 GTPase Era; Reviewed; Region: era; PRK00089 1037911003339 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1037911003340 G1 box; other site 1037911003341 GTP/Mg2+ binding site [chemical binding]; other site 1037911003342 Switch I region; other site 1037911003343 G2 box; other site 1037911003344 Switch II region; other site 1037911003345 G3 box; other site 1037911003346 G4 box; other site 1037911003347 G5 box; other site 1037911003348 KH domain; Region: KH_2; pfam07650 1037911003349 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1037911003350 Recombination protein O N terminal; Region: RecO_N; pfam11967 1037911003351 Recombination protein O C terminal; Region: RecO_C; pfam02565 1037911003352 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1037911003353 active site 1037911003354 hydrophilic channel; other site 1037911003355 dimerization interface [polypeptide binding]; other site 1037911003356 catalytic residues [active] 1037911003357 active site lid [active] 1037911003358 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1037911003359 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1037911003360 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1037911003361 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1037911003362 nucleoside/Zn binding site; other site 1037911003363 dimer interface [polypeptide binding]; other site 1037911003364 catalytic motif [active] 1037911003365 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1037911003366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911003367 S-adenosylmethionine binding site [chemical binding]; other site 1037911003368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911003369 S-adenosylmethionine binding site [chemical binding]; other site 1037911003370 YhhN-like protein; Region: YhhN; pfam07947 1037911003371 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1037911003372 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1037911003373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911003374 Walker A motif; other site 1037911003375 ATP binding site [chemical binding]; other site 1037911003376 Walker B motif; other site 1037911003377 arginine finger; other site 1037911003378 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1037911003379 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1037911003380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911003381 dimerization interface [polypeptide binding]; other site 1037911003382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911003383 metal binding site [ion binding]; metal-binding site 1037911003384 active site 1037911003385 I-site; other site 1037911003386 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911003387 tyrosine decarboxylase; Region: PLN02880 1037911003388 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1037911003389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911003390 catalytic residue [active] 1037911003391 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1037911003392 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1037911003393 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1037911003394 Trp docking motif [polypeptide binding]; other site 1037911003395 putative active site [active] 1037911003396 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1037911003397 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911003398 N-terminal plug; other site 1037911003399 ligand-binding site [chemical binding]; other site 1037911003400 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1037911003401 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1037911003402 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1037911003403 FAD binding pocket [chemical binding]; other site 1037911003404 FAD binding motif [chemical binding]; other site 1037911003405 phosphate binding motif [ion binding]; other site 1037911003406 NAD binding pocket [chemical binding]; other site 1037911003407 Predicted transcriptional regulators [Transcription]; Region: COG1695 1037911003408 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1037911003409 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 1037911003410 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1037911003411 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1037911003412 Leucine-rich repeats; other site 1037911003413 Substrate binding site [chemical binding]; other site 1037911003414 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1037911003415 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1037911003416 Transglycosylase; Region: Transgly; cl17702 1037911003417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1037911003418 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1037911003419 Spore germination protein; Region: Spore_permease; cl17796 1037911003420 Leucine rich repeat; Region: LRR_8; pfam13855 1037911003421 OpgC protein; Region: OpgC_C; pfam10129 1037911003422 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1037911003423 Cupin domain; Region: Cupin_2; pfam07883 1037911003424 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1037911003425 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1037911003426 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1037911003427 active site 1037911003428 FMN binding site [chemical binding]; other site 1037911003429 substrate binding site [chemical binding]; other site 1037911003430 3Fe-4S cluster binding site [ion binding]; other site 1037911003431 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1037911003432 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911003433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003434 active site 1037911003435 phosphorylation site [posttranslational modification] 1037911003436 intermolecular recognition site; other site 1037911003437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911003438 dimerization interface [polypeptide binding]; other site 1037911003439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911003440 dimer interface [polypeptide binding]; other site 1037911003441 phosphorylation site [posttranslational modification] 1037911003442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911003443 ATP binding site [chemical binding]; other site 1037911003444 Mg2+ binding site [ion binding]; other site 1037911003445 G-X-G motif; other site 1037911003446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911003447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911003448 ATP binding site [chemical binding]; other site 1037911003449 Mg2+ binding site [ion binding]; other site 1037911003450 G-X-G motif; other site 1037911003451 cytochrome c-550; Provisional; Region: psbV; cl17239 1037911003452 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1037911003453 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911003454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003455 active site 1037911003456 phosphorylation site [posttranslational modification] 1037911003457 intermolecular recognition site; other site 1037911003458 dimerization interface [polypeptide binding]; other site 1037911003459 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911003460 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911003461 metal binding site [ion binding]; metal-binding site 1037911003462 active site 1037911003463 I-site; other site 1037911003464 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911003465 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1037911003466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003467 active site 1037911003468 phosphorylation site [posttranslational modification] 1037911003469 intermolecular recognition site; other site 1037911003470 dimerization interface [polypeptide binding]; other site 1037911003471 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1037911003472 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1037911003473 nudix motif; other site 1037911003474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911003475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911003476 Coenzyme A binding pocket [chemical binding]; other site 1037911003477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1037911003478 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1037911003479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911003480 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1037911003481 putative dimerization interface [polypeptide binding]; other site 1037911003482 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911003483 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1037911003484 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1037911003485 catalytic residues [active] 1037911003486 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1037911003487 active site 1037911003488 metal binding site [ion binding]; metal-binding site 1037911003489 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1037911003490 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1037911003491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911003492 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1037911003493 inhibitor-cofactor binding pocket; inhibition site 1037911003494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911003495 catalytic residue [active] 1037911003496 Esterase/lipase [General function prediction only]; Region: COG1647 1037911003497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1037911003498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911003499 dimerization interface [polypeptide binding]; other site 1037911003500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911003501 dimer interface [polypeptide binding]; other site 1037911003502 phosphorylation site [posttranslational modification] 1037911003503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911003504 ATP binding site [chemical binding]; other site 1037911003505 Mg2+ binding site [ion binding]; other site 1037911003506 G-X-G motif; other site 1037911003507 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911003508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003509 active site 1037911003510 phosphorylation site [posttranslational modification] 1037911003511 intermolecular recognition site; other site 1037911003512 dimerization interface [polypeptide binding]; other site 1037911003513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911003514 Walker A motif; other site 1037911003515 ATP binding site [chemical binding]; other site 1037911003516 Walker B motif; other site 1037911003517 arginine finger; other site 1037911003518 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911003519 GlpM protein; Region: GlpM; cl01212 1037911003520 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911003521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003522 active site 1037911003523 phosphorylation site [posttranslational modification] 1037911003524 intermolecular recognition site; other site 1037911003525 dimerization interface [polypeptide binding]; other site 1037911003526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911003527 Walker A motif; other site 1037911003528 ATP binding site [chemical binding]; other site 1037911003529 Walker B motif; other site 1037911003530 arginine finger; other site 1037911003531 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911003532 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1037911003533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911003534 dimer interface [polypeptide binding]; other site 1037911003535 phosphorylation site [posttranslational modification] 1037911003536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911003537 ATP binding site [chemical binding]; other site 1037911003538 Mg2+ binding site [ion binding]; other site 1037911003539 G-X-G motif; other site 1037911003540 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1037911003541 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911003542 Walker A/P-loop; other site 1037911003543 ATP binding site [chemical binding]; other site 1037911003544 Q-loop/lid; other site 1037911003545 ABC transporter signature motif; other site 1037911003546 Walker B; other site 1037911003547 D-loop; other site 1037911003548 H-loop/switch region; other site 1037911003549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911003550 dimer interface [polypeptide binding]; other site 1037911003551 conserved gate region; other site 1037911003552 putative PBP binding loops; other site 1037911003553 ABC-ATPase subunit interface; other site 1037911003554 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911003555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911003556 dimer interface [polypeptide binding]; other site 1037911003557 conserved gate region; other site 1037911003558 putative PBP binding loops; other site 1037911003559 ABC-ATPase subunit interface; other site 1037911003560 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1037911003561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911003562 substrate binding pocket [chemical binding]; other site 1037911003563 membrane-bound complex binding site; other site 1037911003564 hinge residues; other site 1037911003565 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1037911003566 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1037911003567 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1037911003568 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1037911003569 glycerol kinase; Provisional; Region: glpK; PRK00047 1037911003570 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1037911003571 N- and C-terminal domain interface [polypeptide binding]; other site 1037911003572 active site 1037911003573 MgATP binding site [chemical binding]; other site 1037911003574 catalytic site [active] 1037911003575 metal binding site [ion binding]; metal-binding site 1037911003576 glycerol binding site [chemical binding]; other site 1037911003577 homotetramer interface [polypeptide binding]; other site 1037911003578 homodimer interface [polypeptide binding]; other site 1037911003579 protein IIAGlc interface [polypeptide binding]; other site 1037911003580 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1037911003581 amphipathic channel; other site 1037911003582 Asn-Pro-Ala signature motifs; other site 1037911003583 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1037911003584 putative deacylase active site [active] 1037911003585 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1037911003586 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1037911003587 Walker A/P-loop; other site 1037911003588 ATP binding site [chemical binding]; other site 1037911003589 Q-loop/lid; other site 1037911003590 ABC transporter signature motif; other site 1037911003591 Walker B; other site 1037911003592 D-loop; other site 1037911003593 H-loop/switch region; other site 1037911003594 TOBE domain; Region: TOBE_2; pfam08402 1037911003595 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1037911003596 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1037911003597 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1037911003598 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1037911003599 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1037911003600 putative [Fe4-S4] binding site [ion binding]; other site 1037911003601 putative molybdopterin cofactor binding site [chemical binding]; other site 1037911003602 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1037911003603 putative molybdopterin cofactor binding site; other site 1037911003604 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1037911003605 putative GSH binding site [chemical binding]; other site 1037911003606 catalytic residues [active] 1037911003607 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1037911003608 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1037911003609 heme binding site [chemical binding]; other site 1037911003610 ferroxidase pore; other site 1037911003611 ferroxidase diiron center [ion binding]; other site 1037911003612 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1037911003613 peroxidase; Provisional; Region: PRK15000 1037911003614 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1037911003615 dimer interface [polypeptide binding]; other site 1037911003616 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1037911003617 catalytic triad [active] 1037911003618 peroxidatic and resolving cysteines [active] 1037911003619 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1037911003620 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1037911003621 dimer interface [polypeptide binding]; other site 1037911003622 catalytic site [active] 1037911003623 putative active site [active] 1037911003624 putative substrate binding site [chemical binding]; other site 1037911003625 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1037911003626 active site 1037911003627 substrate binding pocket [chemical binding]; other site 1037911003628 dimer interface [polypeptide binding]; other site 1037911003629 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1037911003630 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911003631 ligand binding site [chemical binding]; other site 1037911003632 argininosuccinate synthase; Provisional; Region: PRK13820 1037911003633 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1037911003634 ANP binding site [chemical binding]; other site 1037911003635 Substrate Binding Site II [chemical binding]; other site 1037911003636 Substrate Binding Site I [chemical binding]; other site 1037911003637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911003638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003639 active site 1037911003640 phosphorylation site [posttranslational modification] 1037911003641 intermolecular recognition site; other site 1037911003642 dimerization interface [polypeptide binding]; other site 1037911003643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911003644 DNA binding residues [nucleotide binding] 1037911003645 dimerization interface [polypeptide binding]; other site 1037911003646 endonuclease III; Provisional; Region: PRK10702 1037911003647 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1037911003648 minor groove reading motif; other site 1037911003649 helix-hairpin-helix signature motif; other site 1037911003650 substrate binding pocket [chemical binding]; other site 1037911003651 active site 1037911003652 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1037911003653 ferredoxin; Provisional; Region: PRK08764 1037911003654 Putative Fe-S cluster; Region: FeS; pfam04060 1037911003655 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1037911003656 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1037911003657 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1037911003658 active site 1037911003659 HIGH motif; other site 1037911003660 KMSKS motif; other site 1037911003661 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1037911003662 tRNA binding surface [nucleotide binding]; other site 1037911003663 anticodon binding site; other site 1037911003664 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1037911003665 dimer interface [polypeptide binding]; other site 1037911003666 putative tRNA-binding site [nucleotide binding]; other site 1037911003667 antiporter inner membrane protein; Provisional; Region: PRK11670 1037911003668 Domain of unknown function DUF59; Region: DUF59; pfam01883 1037911003669 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1037911003670 Ferredoxin [Energy production and conversion]; Region: COG1146 1037911003671 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1037911003672 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1037911003673 MutS domain I; Region: MutS_I; pfam01624 1037911003674 MutS domain II; Region: MutS_II; pfam05188 1037911003675 MutS domain III; Region: MutS_III; pfam05192 1037911003676 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1037911003677 Walker A/P-loop; other site 1037911003678 ATP binding site [chemical binding]; other site 1037911003679 Q-loop/lid; other site 1037911003680 ABC transporter signature motif; other site 1037911003681 Walker B; other site 1037911003682 D-loop; other site 1037911003683 H-loop/switch region; other site 1037911003684 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1037911003685 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1037911003686 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1037911003687 Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxy acid dehydrogenase family; Region: formate_dh_like; cd05198 1037911003688 ligand binding site [chemical binding]; other site 1037911003689 NAD binding site [chemical binding]; other site 1037911003690 dimerization interface [polypeptide binding]; other site 1037911003691 catalytic site [active] 1037911003692 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1037911003693 Y-family of DNA polymerases; Region: PolY; cl12025 1037911003694 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1037911003695 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1037911003696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911003697 non-specific DNA binding site [nucleotide binding]; other site 1037911003698 salt bridge; other site 1037911003699 sequence-specific DNA binding site [nucleotide binding]; other site 1037911003700 Predicted transcriptional regulator [Transcription]; Region: COG2932 1037911003701 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1037911003702 Catalytic site [active] 1037911003703 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1037911003704 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1037911003705 Baseplate J-like protein; Region: Baseplate_J; cl01294 1037911003706 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1037911003707 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1037911003708 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1037911003709 Phage tail tube protein FII; Region: Phage_tube; cl01390 1037911003710 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1037911003711 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1037911003712 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1037911003713 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 1037911003714 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1037911003715 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1037911003716 Predicted chitinase [General function prediction only]; Region: COG3179 1037911003717 catalytic residue [active] 1037911003718 Competence-damaged protein; Region: CinA; cl00666 1037911003719 recombinase A; Provisional; Region: recA; PRK09354 1037911003720 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1037911003721 hexamer interface [polypeptide binding]; other site 1037911003722 Walker A motif; other site 1037911003723 ATP binding site [chemical binding]; other site 1037911003724 Walker B motif; other site 1037911003725 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1037911003726 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1037911003727 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1037911003728 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1037911003729 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911003730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003731 active site 1037911003732 phosphorylation site [posttranslational modification] 1037911003733 intermolecular recognition site; other site 1037911003734 dimerization interface [polypeptide binding]; other site 1037911003735 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911003736 DNA binding residues [nucleotide binding] 1037911003737 dimerization interface [polypeptide binding]; other site 1037911003738 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1037911003739 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1037911003740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911003741 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1037911003742 putative dimerization interface [polypeptide binding]; other site 1037911003743 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1037911003744 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1037911003745 FAD binding pocket [chemical binding]; other site 1037911003746 FAD binding motif [chemical binding]; other site 1037911003747 phosphate binding motif [ion binding]; other site 1037911003748 beta-alpha-beta structure motif; other site 1037911003749 NAD binding pocket [chemical binding]; other site 1037911003750 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1037911003751 homodimer interaction site [polypeptide binding]; other site 1037911003752 cofactor binding site; other site 1037911003753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1037911003754 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1037911003755 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1037911003756 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1037911003757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1037911003758 RNA binding surface [nucleotide binding]; other site 1037911003759 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 1037911003760 active site 1037911003761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1037911003762 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1037911003763 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1037911003764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911003765 FeS/SAM binding site; other site 1037911003766 TRAM domain; Region: TRAM; cl01282 1037911003767 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1037911003768 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1037911003769 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1037911003770 potassium uptake protein; Region: kup; TIGR00794 1037911003771 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911003772 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1037911003773 active site 1037911003774 FMN binding site [chemical binding]; other site 1037911003775 substrate binding site [chemical binding]; other site 1037911003776 homotetramer interface [polypeptide binding]; other site 1037911003777 catalytic residue [active] 1037911003778 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1037911003779 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1037911003780 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1037911003781 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1037911003782 putative metal binding site [ion binding]; other site 1037911003783 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1037911003784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911003785 dimerization interface [polypeptide binding]; other site 1037911003786 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911003787 dimer interface [polypeptide binding]; other site 1037911003788 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1037911003789 putative CheW interface [polypeptide binding]; other site 1037911003790 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1037911003791 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1037911003792 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1037911003793 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1037911003794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911003795 binding surface 1037911003796 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1037911003797 TPR motif; other site 1037911003798 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1037911003799 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911003800 putative binding surface; other site 1037911003801 active site 1037911003802 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1037911003803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911003804 ATP binding site [chemical binding]; other site 1037911003805 Mg2+ binding site [ion binding]; other site 1037911003806 G-X-G motif; other site 1037911003807 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1037911003808 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911003809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003810 active site 1037911003811 phosphorylation site [posttranslational modification] 1037911003812 intermolecular recognition site; other site 1037911003813 dimerization interface [polypeptide binding]; other site 1037911003814 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1037911003815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003816 active site 1037911003817 phosphorylation site [posttranslational modification] 1037911003818 intermolecular recognition site; other site 1037911003819 CheB methylesterase; Region: CheB_methylest; pfam01339 1037911003820 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911003821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911003822 active site 1037911003823 phosphorylation site [posttranslational modification] 1037911003824 intermolecular recognition site; other site 1037911003825 dimerization interface [polypeptide binding]; other site 1037911003826 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911003827 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911003828 metal binding site [ion binding]; metal-binding site 1037911003829 active site 1037911003830 I-site; other site 1037911003831 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1037911003832 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1037911003833 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1037911003834 RF-1 domain; Region: RF-1; pfam00472 1037911003835 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1037911003836 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1037911003837 dimer interface [polypeptide binding]; other site 1037911003838 putative anticodon binding site; other site 1037911003839 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1037911003840 motif 1; other site 1037911003841 active site 1037911003842 motif 2; other site 1037911003843 motif 3; other site 1037911003844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1037911003845 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1037911003846 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911003847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911003848 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1037911003849 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1037911003850 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911003851 ligand binding site [chemical binding]; other site 1037911003852 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1037911003853 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1037911003854 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1037911003855 adenylate kinase; Reviewed; Region: adk; PRK00279 1037911003856 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1037911003857 AMP-binding site [chemical binding]; other site 1037911003858 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1037911003859 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1037911003860 Glycoprotease family; Region: Peptidase_M22; pfam00814 1037911003861 Protein of unknown function DUF72; Region: DUF72; cl00777 1037911003862 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1037911003863 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1037911003864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911003865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911003866 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1037911003867 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911003868 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911003869 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911003870 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1037911003871 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1037911003872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1037911003873 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1037911003874 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1037911003875 putative acyl-acceptor binding pocket; other site 1037911003876 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1037911003877 DNA-binding site [nucleotide binding]; DNA binding site 1037911003878 RNA-binding motif; other site 1037911003879 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1037911003880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911003881 S-adenosylmethionine binding site [chemical binding]; other site 1037911003882 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1037911003883 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1037911003884 metal binding site [ion binding]; metal-binding site 1037911003885 dimer interface [polypeptide binding]; other site 1037911003886 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1037911003887 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1037911003888 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 1037911003889 Ligand binding site; other site 1037911003890 DXD motif; other site 1037911003891 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1037911003892 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1037911003893 putative ATP binding site [chemical binding]; other site 1037911003894 putative substrate interface [chemical binding]; other site 1037911003895 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1037911003896 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1037911003897 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1037911003898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911003899 catalytic residue [active] 1037911003900 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1037911003901 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1037911003902 putative trimer interface [polypeptide binding]; other site 1037911003903 putative CoA binding site [chemical binding]; other site 1037911003904 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1037911003905 ArsC family; Region: ArsC; pfam03960 1037911003906 putative catalytic residues [active] 1037911003907 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1037911003908 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1037911003909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911003910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911003911 homodimer interface [polypeptide binding]; other site 1037911003912 catalytic residue [active] 1037911003913 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1037911003914 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1037911003915 metal binding triad; other site 1037911003916 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1037911003917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1037911003918 Zn2+ binding site [ion binding]; other site 1037911003919 Mg2+ binding site [ion binding]; other site 1037911003920 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1037911003921 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1037911003922 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1037911003923 active site 1037911003924 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1037911003925 rRNA interaction site [nucleotide binding]; other site 1037911003926 S8 interaction site; other site 1037911003927 putative laminin-1 binding site; other site 1037911003928 elongation factor Ts; Provisional; Region: tsf; PRK09377 1037911003929 UBA/TS-N domain; Region: UBA; pfam00627 1037911003930 Elongation factor TS; Region: EF_TS; pfam00889 1037911003931 Elongation factor TS; Region: EF_TS; pfam00889 1037911003932 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1037911003933 putative nucleotide binding site [chemical binding]; other site 1037911003934 uridine monophosphate binding site [chemical binding]; other site 1037911003935 homohexameric interface [polypeptide binding]; other site 1037911003936 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1037911003937 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1037911003938 hinge region; other site 1037911003939 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1037911003940 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1037911003941 catalytic residue [active] 1037911003942 putative FPP diphosphate binding site; other site 1037911003943 putative FPP binding hydrophobic cleft; other site 1037911003944 dimer interface [polypeptide binding]; other site 1037911003945 putative IPP diphosphate binding site; other site 1037911003946 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1037911003947 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1037911003948 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1037911003949 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1037911003950 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1037911003951 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1037911003952 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1037911003953 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1037911003954 active site 1037911003955 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1037911003956 protein binding site [polypeptide binding]; other site 1037911003957 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1037911003958 protein binding site [polypeptide binding]; other site 1037911003959 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1037911003960 putative substrate binding region [chemical binding]; other site 1037911003961 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1037911003962 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1037911003963 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1037911003964 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1037911003965 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1037911003966 Surface antigen; Region: Bac_surface_Ag; pfam01103 1037911003967 periplasmic chaperone; Provisional; Region: PRK10780 1037911003968 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1037911003969 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1037911003970 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1037911003971 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1037911003972 trimer interface [polypeptide binding]; other site 1037911003973 active site 1037911003974 UDP-GlcNAc binding site [chemical binding]; other site 1037911003975 lipid binding site [chemical binding]; lipid-binding site 1037911003976 Heat shock factor binding protein 1; Region: HSBP1; pfam06825 1037911003977 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1037911003978 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1037911003979 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1037911003980 active site 1037911003981 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1037911003982 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1037911003983 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1037911003984 RNA/DNA hybrid binding site [nucleotide binding]; other site 1037911003985 active site 1037911003986 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1037911003987 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1037911003988 putative active site [active] 1037911003989 putative PHP Thumb interface [polypeptide binding]; other site 1037911003990 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1037911003991 generic binding surface II; other site 1037911003992 generic binding surface I; other site 1037911003993 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1037911003994 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1037911003995 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1037911003996 Ligand Binding Site [chemical binding]; other site 1037911003997 TilS substrate binding domain; Region: TilS; pfam09179 1037911003998 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1037911003999 CTP synthetase; Validated; Region: pyrG; PRK05380 1037911004000 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1037911004001 Catalytic site [active] 1037911004002 active site 1037911004003 UTP binding site [chemical binding]; other site 1037911004004 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1037911004005 active site 1037911004006 putative oxyanion hole; other site 1037911004007 catalytic triad [active] 1037911004008 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1037911004009 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1037911004010 enolase; Provisional; Region: eno; PRK00077 1037911004011 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1037911004012 dimer interface [polypeptide binding]; other site 1037911004013 metal binding site [ion binding]; metal-binding site 1037911004014 substrate binding pocket [chemical binding]; other site 1037911004015 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1037911004016 Septum formation initiator; Region: DivIC; cl17659 1037911004017 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1037911004018 substrate binding site; other site 1037911004019 dimer interface; other site 1037911004020 LysR family transcriptional regulator; Provisional; Region: PRK14997 1037911004021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004022 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 1037911004023 putative effector binding pocket; other site 1037911004024 putative dimerization interface [polypeptide binding]; other site 1037911004025 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1037911004026 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1037911004027 substrate binding site [chemical binding]; other site 1037911004028 catalytic Zn binding site [ion binding]; other site 1037911004029 NAD binding site [chemical binding]; other site 1037911004030 structural Zn binding site [ion binding]; other site 1037911004031 dimer interface [polypeptide binding]; other site 1037911004032 S-formylglutathione hydrolase; Region: PLN02442 1037911004033 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1037911004034 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1037911004035 homotrimer interaction site [polypeptide binding]; other site 1037911004036 zinc binding site [ion binding]; other site 1037911004037 CDP-binding sites; other site 1037911004038 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1037911004039 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1037911004040 Permutation of conserved domain; other site 1037911004041 active site 1037911004042 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1037911004043 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1037911004044 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1037911004045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911004046 S-adenosylmethionine binding site [chemical binding]; other site 1037911004047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1037911004048 Peptidase family M23; Region: Peptidase_M23; pfam01551 1037911004049 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1037911004050 DNA-binding site [nucleotide binding]; DNA binding site 1037911004051 RNA-binding motif; other site 1037911004052 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1037911004053 trimer interface [polypeptide binding]; other site 1037911004054 active site 1037911004055 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1037911004056 putative active site [active] 1037911004057 putative metal binding site [ion binding]; other site 1037911004058 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1037911004059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911004060 ATP binding site [chemical binding]; other site 1037911004061 putative Mg++ binding site [ion binding]; other site 1037911004062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911004063 nucleotide binding region [chemical binding]; other site 1037911004064 ATP-binding site [chemical binding]; other site 1037911004065 DEAD/H associated; Region: DEAD_assoc; pfam08494 1037911004066 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1037911004067 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911004068 Walker A/P-loop; other site 1037911004069 ATP binding site [chemical binding]; other site 1037911004070 Q-loop/lid; other site 1037911004071 ABC transporter signature motif; other site 1037911004072 Walker B; other site 1037911004073 D-loop; other site 1037911004074 H-loop/switch region; other site 1037911004075 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1037911004076 active site 1037911004077 Zn binding site [ion binding]; other site 1037911004078 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911004079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911004080 dimer interface [polypeptide binding]; other site 1037911004081 conserved gate region; other site 1037911004082 putative PBP binding loops; other site 1037911004083 ABC-ATPase subunit interface; other site 1037911004084 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911004085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911004086 dimer interface [polypeptide binding]; other site 1037911004087 conserved gate region; other site 1037911004088 putative PBP binding loops; other site 1037911004089 ABC-ATPase subunit interface; other site 1037911004090 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1037911004091 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911004092 substrate binding pocket [chemical binding]; other site 1037911004093 membrane-bound complex binding site; other site 1037911004094 hinge residues; other site 1037911004095 ATP-dependent DNA ligase; Validated; Region: PRK09247 1037911004096 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1037911004097 active site 1037911004098 DNA binding site [nucleotide binding] 1037911004099 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1037911004100 DNA binding site [nucleotide binding] 1037911004101 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1037911004102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1037911004103 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1037911004104 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1037911004105 active site 1037911004106 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 1037911004107 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1037911004108 hypothetical protein; Provisional; Region: PRK00183 1037911004109 SEC-C motif; Region: SEC-C; pfam02810 1037911004110 Predicted integral membrane protein [Function unknown]; Region: COG5615 1037911004111 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1037911004112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1037911004113 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1037911004114 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1037911004115 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1037911004116 Beta-lactamase; Region: Beta-lactamase; pfam00144 1037911004117 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1037911004118 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911004119 ligand binding site [chemical binding]; other site 1037911004120 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1037911004121 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1037911004122 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1037911004123 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1037911004124 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1037911004125 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1037911004126 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1037911004127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911004128 catalytic residue [active] 1037911004129 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1037911004130 Predicted membrane protein [Function unknown]; Region: COG3650 1037911004131 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1037911004132 putative NAD(P) binding site [chemical binding]; other site 1037911004133 homodimer interface [polypeptide binding]; other site 1037911004134 transcriptional regulator; Provisional; Region: PRK10632 1037911004135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004136 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911004137 putative effector binding pocket; other site 1037911004138 dimerization interface [polypeptide binding]; other site 1037911004139 DoxX; Region: DoxX; pfam07681 1037911004140 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1037911004141 hypothetical protein; Provisional; Region: PRK05409 1037911004142 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1037911004143 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1037911004144 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1037911004145 Walker A/P-loop; other site 1037911004146 ATP binding site [chemical binding]; other site 1037911004147 Q-loop/lid; other site 1037911004148 ABC transporter signature motif; other site 1037911004149 Walker B; other site 1037911004150 D-loop; other site 1037911004151 H-loop/switch region; other site 1037911004152 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1037911004153 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1037911004154 Walker A/P-loop; other site 1037911004155 ATP binding site [chemical binding]; other site 1037911004156 Q-loop/lid; other site 1037911004157 ABC transporter signature motif; other site 1037911004158 Walker B; other site 1037911004159 D-loop; other site 1037911004160 H-loop/switch region; other site 1037911004161 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1037911004162 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1037911004163 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1037911004164 TM-ABC transporter signature motif; other site 1037911004165 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911004166 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1037911004167 TM-ABC transporter signature motif; other site 1037911004168 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1037911004169 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1037911004170 dimerization interface [polypeptide binding]; other site 1037911004171 ligand binding site [chemical binding]; other site 1037911004172 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1037911004173 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1037911004174 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1037911004175 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1037911004176 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1037911004177 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911004178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911004179 metal binding site [ion binding]; metal-binding site 1037911004180 active site 1037911004181 I-site; other site 1037911004182 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911004183 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1037911004184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004185 putative substrate translocation pore; other site 1037911004186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911004187 ATP-dependent helicase HepA; Validated; Region: PRK04914 1037911004188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911004189 ATP binding site [chemical binding]; other site 1037911004190 putative Mg++ binding site [ion binding]; other site 1037911004191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911004192 nucleotide binding region [chemical binding]; other site 1037911004193 ATP-binding site [chemical binding]; other site 1037911004194 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1037911004195 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1037911004196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911004197 catalytic residue [active] 1037911004198 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1037911004199 homotrimer interaction site [polypeptide binding]; other site 1037911004200 putative active site [active] 1037911004201 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1037911004202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004203 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1037911004204 dimerization interface [polypeptide binding]; other site 1037911004205 substrate binding pocket [chemical binding]; other site 1037911004206 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1037911004207 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1037911004208 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1037911004209 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1037911004210 Bacterial transcriptional regulator; Region: IclR; pfam01614 1037911004211 benzoate transport; Region: 2A0115; TIGR00895 1037911004212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004213 putative substrate translocation pore; other site 1037911004214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004215 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1037911004216 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1037911004217 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1037911004218 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1037911004219 dimer interface [polypeptide binding]; other site 1037911004220 active site 1037911004221 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1037911004222 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1037911004223 heterodimer interface [polypeptide binding]; other site 1037911004224 multimer interface [polypeptide binding]; other site 1037911004225 active site 1037911004226 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1037911004227 heterodimer interface [polypeptide binding]; other site 1037911004228 active site 1037911004229 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1037911004230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004231 putative substrate translocation pore; other site 1037911004232 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1037911004233 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1037911004234 tetramer interface [polypeptide binding]; other site 1037911004235 active site 1037911004236 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1037911004237 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1037911004238 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1037911004239 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1037911004240 NodB motif; other site 1037911004241 active site 1037911004242 catalytic site [active] 1037911004243 metal binding site [ion binding]; metal-binding site 1037911004244 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911004245 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1037911004246 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1037911004247 Protein export membrane protein; Region: SecD_SecF; cl14618 1037911004248 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1037911004249 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911004250 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911004251 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1037911004252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911004253 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1037911004254 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1037911004255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1037911004256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1037911004257 active site 1037911004258 CoA binding site [chemical binding]; other site 1037911004259 AMP binding site [chemical binding]; other site 1037911004260 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1037911004261 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1037911004262 EamA-like transporter family; Region: EamA; pfam00892 1037911004263 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911004264 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1037911004265 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1037911004266 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1037911004267 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1037911004268 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1037911004269 glutamine binding [chemical binding]; other site 1037911004270 catalytic triad [active] 1037911004271 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1037911004272 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 1037911004273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911004274 DNA binding residues [nucleotide binding] 1037911004275 dimerization interface [polypeptide binding]; other site 1037911004276 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911004277 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1037911004278 FMN binding site [chemical binding]; other site 1037911004279 active site 1037911004280 substrate binding site [chemical binding]; other site 1037911004281 catalytic residue [active] 1037911004282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004283 putative substrate translocation pore; other site 1037911004284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911004285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911004286 dimerization interface [polypeptide binding]; other site 1037911004287 putative DNA binding site [nucleotide binding]; other site 1037911004288 putative Zn2+ binding site [ion binding]; other site 1037911004289 Protein of unknown function, DUF479; Region: DUF479; cl01203 1037911004290 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1037911004291 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1037911004292 putative acyl-acceptor binding pocket; other site 1037911004293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1037911004294 Beta-lactamase; Region: Beta-lactamase; pfam00144 1037911004295 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1037911004296 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1037911004297 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1037911004298 metal binding site [ion binding]; metal-binding site 1037911004299 putative dimer interface [polypeptide binding]; other site 1037911004300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004301 metabolite-proton symporter; Region: 2A0106; TIGR00883 1037911004302 putative substrate translocation pore; other site 1037911004303 amidase; Provisional; Region: PRK07486 1037911004304 Amidase; Region: Amidase; pfam01425 1037911004305 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1037911004306 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1037911004307 YceI-like domain; Region: YceI; pfam04264 1037911004308 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1037911004309 PLD-like domain; Region: PLDc_2; pfam13091 1037911004310 putative active site [active] 1037911004311 catalytic site [active] 1037911004312 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1037911004313 PLD-like domain; Region: PLDc_2; pfam13091 1037911004314 putative active site [active] 1037911004315 catalytic site [active] 1037911004316 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1037911004317 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1037911004318 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1037911004319 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1037911004320 Repair protein; Region: Repair_PSII; pfam04536 1037911004321 Repair protein; Region: Repair_PSII; cl01535 1037911004322 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1037911004323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911004324 S-adenosylmethionine binding site [chemical binding]; other site 1037911004325 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911004326 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1037911004327 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911004328 N-terminal plug; other site 1037911004329 ligand-binding site [chemical binding]; other site 1037911004330 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1037911004331 FecR protein; Region: FecR; pfam04773 1037911004332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911004333 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1037911004334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911004335 DNA binding residues [nucleotide binding] 1037911004336 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1037911004337 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1037911004338 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1037911004339 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1037911004340 inhibitor site; inhibition site 1037911004341 active site 1037911004342 dimer interface [polypeptide binding]; other site 1037911004343 catalytic residue [active] 1037911004344 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1037911004345 intersubunit interface [polypeptide binding]; other site 1037911004346 active site 1037911004347 Zn2+ binding site [ion binding]; other site 1037911004348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911004349 non-specific DNA binding site [nucleotide binding]; other site 1037911004350 salt bridge; other site 1037911004351 sequence-specific DNA binding site [nucleotide binding]; other site 1037911004352 Cupin domain; Region: Cupin_2; pfam07883 1037911004353 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1037911004354 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1037911004355 dimer interface [polypeptide binding]; other site 1037911004356 active site 1037911004357 metal binding site [ion binding]; metal-binding site 1037911004358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004359 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1037911004360 putative substrate translocation pore; other site 1037911004361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911004362 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1037911004363 NAD(P) binding site [chemical binding]; other site 1037911004364 active site 1037911004365 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1037911004366 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004368 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 1037911004369 putative substrate binding pocket [chemical binding]; other site 1037911004370 putative dimerization interface [polypeptide binding]; other site 1037911004371 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1037911004372 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1037911004373 active site 1037911004374 metal binding site [ion binding]; metal-binding site 1037911004375 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1037911004376 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1037911004377 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1037911004378 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1037911004379 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1037911004380 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1037911004381 DNA binding site [nucleotide binding] 1037911004382 active site 1037911004383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911004384 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1037911004385 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1037911004386 active site 1037911004387 uracil binding [chemical binding]; other site 1037911004388 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1037911004389 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1037911004390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911004391 substrate binding site [chemical binding]; other site 1037911004392 oxyanion hole (OAH) forming residues; other site 1037911004393 trimer interface [polypeptide binding]; other site 1037911004394 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1037911004395 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1037911004396 ligand binding site [chemical binding]; other site 1037911004397 active site 1037911004398 UGI interface [polypeptide binding]; other site 1037911004399 catalytic site [active] 1037911004400 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1037911004401 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1037911004402 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1037911004403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1037911004404 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1037911004405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1037911004406 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911004407 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1037911004408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911004409 active site 1037911004410 phosphorylation site [posttranslational modification] 1037911004411 intermolecular recognition site; other site 1037911004412 dimerization interface [polypeptide binding]; other site 1037911004413 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911004414 DNA binding site [nucleotide binding] 1037911004415 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1037911004416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911004417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911004418 dimerization interface [polypeptide binding]; other site 1037911004419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911004420 dimer interface [polypeptide binding]; other site 1037911004421 phosphorylation site [posttranslational modification] 1037911004422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911004423 ATP binding site [chemical binding]; other site 1037911004424 Mg2+ binding site [ion binding]; other site 1037911004425 G-X-G motif; other site 1037911004426 HDOD domain; Region: HDOD; pfam08668 1037911004427 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1037911004428 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1037911004429 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1037911004430 L-aspartate oxidase; Provisional; Region: PRK09077 1037911004431 L-aspartate oxidase; Provisional; Region: PRK06175 1037911004432 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1037911004433 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1037911004434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911004435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911004436 DNA binding residues [nucleotide binding] 1037911004437 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1037911004438 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1037911004439 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1037911004440 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1037911004441 MucB/RseB family; Region: MucB_RseB; pfam03888 1037911004442 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1037911004443 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1037911004444 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1037911004445 protein binding site [polypeptide binding]; other site 1037911004446 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1037911004447 protein binding site [polypeptide binding]; other site 1037911004448 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1037911004449 Peptidase family M48; Region: Peptidase_M48; cl12018 1037911004450 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1037911004451 CPxP motif; other site 1037911004452 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1037911004453 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1037911004454 catalytic triad [active] 1037911004455 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1037911004456 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1037911004457 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1037911004458 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1037911004459 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1037911004460 dimer interface [polypeptide binding]; other site 1037911004461 active site 1037911004462 catalytic residue [active] 1037911004463 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1037911004464 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1037911004465 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1037911004466 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1037911004467 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1037911004468 ATP binding site [chemical binding]; other site 1037911004469 active site 1037911004470 substrate binding site [chemical binding]; other site 1037911004471 Colicin pore forming domain; Region: Colicin; pfam01024 1037911004472 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 1037911004473 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1037911004474 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 1037911004475 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1037911004476 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1037911004477 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1037911004478 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1037911004479 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1037911004480 active site 1037911004481 DNA binding site [nucleotide binding] 1037911004482 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1037911004483 DNA binding site [nucleotide binding] 1037911004484 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1037911004485 nucleotide binding site [chemical binding]; other site 1037911004486 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1037911004487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911004488 non-specific DNA binding site [nucleotide binding]; other site 1037911004489 salt bridge; other site 1037911004490 sequence-specific DNA binding site [nucleotide binding]; other site 1037911004491 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1037911004492 HEPN domain; Region: HEPN; cl00824 1037911004493 potential frameshift: common BLAST hit: gi|189218339|ref|YP_001938981.1| PHP family phosphoesterase fused to chromosome segregation ATPase 1037911004494 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1037911004495 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1037911004496 active site 1037911004497 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1037911004498 PHP-associated; Region: PHP_C; pfam13263 1037911004499 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1037911004500 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1037911004501 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1037911004502 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1037911004503 AAA domain; Region: AAA_31; pfam13614 1037911004504 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1037911004505 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1037911004506 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1037911004507 Protein of unknown function DUF91; Region: DUF91; cl00709 1037911004508 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1037911004509 GIY-YIG motif/motif A; other site 1037911004510 putative active site [active] 1037911004511 putative metal binding site [ion binding]; other site 1037911004512 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1037911004513 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1037911004514 active site 1037911004515 DNA binding site [nucleotide binding] 1037911004516 Int/Topo IB signature motif; other site 1037911004517 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1037911004518 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1037911004519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004520 putative substrate translocation pore; other site 1037911004521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911004522 non-specific DNA binding site [nucleotide binding]; other site 1037911004523 salt bridge; other site 1037911004524 sequence-specific DNA binding site [nucleotide binding]; other site 1037911004525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911004528 dimerization interface [polypeptide binding]; other site 1037911004529 metabolite-proton symporter; Region: 2A0106; TIGR00883 1037911004530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004531 putative substrate translocation pore; other site 1037911004532 allantoate amidohydrolase; Reviewed; Region: PRK12893 1037911004533 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1037911004534 active site 1037911004535 metal binding site [ion binding]; metal-binding site 1037911004536 dimer interface [polypeptide binding]; other site 1037911004537 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1037911004538 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1037911004539 active site 1037911004540 Zn binding site [ion binding]; other site 1037911004541 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1037911004542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004544 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1037911004545 putative dimerization interface [polypeptide binding]; other site 1037911004546 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1037911004547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911004548 citrate-proton symporter; Provisional; Region: PRK15075 1037911004549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004550 putative substrate translocation pore; other site 1037911004551 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1037911004552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911004553 DNA-binding site [nucleotide binding]; DNA binding site 1037911004554 FCD domain; Region: FCD; pfam07729 1037911004555 short chain dehydrogenase; Provisional; Region: PRK12829 1037911004556 classical (c) SDRs; Region: SDR_c; cd05233 1037911004557 NAD(P) binding site [chemical binding]; other site 1037911004558 active site 1037911004559 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1037911004560 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1037911004561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004562 putative substrate translocation pore; other site 1037911004563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004565 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1037911004566 putative substrate binding pocket [chemical binding]; other site 1037911004567 putative dimerization interface [polypeptide binding]; other site 1037911004568 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1037911004569 putative substrate binding pocket [chemical binding]; other site 1037911004570 trimer interface [polypeptide binding]; other site 1037911004571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911004573 putative Zn2+ binding site [ion binding]; other site 1037911004574 putative DNA binding site [nucleotide binding]; other site 1037911004575 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1037911004576 substrate binding pocket [chemical binding]; other site 1037911004577 dimerization interface [polypeptide binding]; other site 1037911004578 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1037911004579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004580 hypothetical protein; Provisional; Region: PRK07524 1037911004581 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1037911004582 PYR/PP interface [polypeptide binding]; other site 1037911004583 dimer interface [polypeptide binding]; other site 1037911004584 TPP binding site [chemical binding]; other site 1037911004585 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1037911004586 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1037911004587 TPP-binding site [chemical binding]; other site 1037911004588 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1037911004589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004590 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1037911004591 substrate binding pocket [chemical binding]; other site 1037911004592 dimerization interface [polypeptide binding]; other site 1037911004593 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1037911004594 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1037911004595 NAD binding site [chemical binding]; other site 1037911004596 putative active site [active] 1037911004597 substrate binding site [chemical binding]; other site 1037911004598 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1037911004599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004601 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911004602 putative effector binding pocket; other site 1037911004603 dimerization interface [polypeptide binding]; other site 1037911004604 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1037911004605 Cupin domain; Region: Cupin_2; cl17218 1037911004606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911004607 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1037911004608 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1037911004609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911004611 putative substrate translocation pore; other site 1037911004612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004613 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1037911004614 cyanate hydratase; Validated; Region: PRK02866 1037911004615 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1037911004616 oligomer interface [polypeptide binding]; other site 1037911004617 active site 1037911004618 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1037911004619 active site clefts [active] 1037911004620 zinc binding site [ion binding]; other site 1037911004621 dimer interface [polypeptide binding]; other site 1037911004622 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1037911004623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004624 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1037911004625 dimerization interface [polypeptide binding]; other site 1037911004626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911004627 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911004628 substrate binding pocket [chemical binding]; other site 1037911004629 membrane-bound complex binding site; other site 1037911004630 hinge residues; other site 1037911004631 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1037911004632 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1037911004633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911004634 S-adenosylmethionine binding site [chemical binding]; other site 1037911004635 ribonuclease D; Region: rnd; TIGR01388 1037911004636 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1037911004637 catalytic site [active] 1037911004638 putative active site [active] 1037911004639 putative substrate binding site [chemical binding]; other site 1037911004640 HRDC domain; Region: HRDC; pfam00570 1037911004641 YcgL domain; Region: YcgL; cl01189 1037911004642 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1037911004643 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1037911004644 NAD binding site [chemical binding]; other site 1037911004645 ligand binding site [chemical binding]; other site 1037911004646 catalytic site [active] 1037911004647 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1037911004648 putative FMN binding site [chemical binding]; other site 1037911004649 hypothetical protein; Provisional; Region: PRK05170 1037911004650 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1037911004651 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1037911004652 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1037911004653 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1037911004654 active site 1037911004655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1037911004656 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1037911004657 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1037911004658 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1037911004659 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1037911004660 putative active site [active] 1037911004661 putative dimer interface [polypeptide binding]; other site 1037911004662 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1037911004663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004665 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911004666 dimerization interface [polypeptide binding]; other site 1037911004667 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1037911004668 putative active site [active] 1037911004669 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1037911004670 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1037911004671 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1037911004672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1037911004673 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1037911004674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911004675 Walker A motif; other site 1037911004676 ATP binding site [chemical binding]; other site 1037911004677 Walker B motif; other site 1037911004678 arginine finger; other site 1037911004679 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1037911004680 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1037911004681 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1037911004682 dimer interface [polypeptide binding]; other site 1037911004683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911004684 catalytic residue [active] 1037911004685 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1037911004686 aconitate hydratase; Validated; Region: PRK09277 1037911004687 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1037911004688 substrate binding site [chemical binding]; other site 1037911004689 ligand binding site [chemical binding]; other site 1037911004690 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1037911004691 substrate binding site [chemical binding]; other site 1037911004692 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1037911004693 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1037911004694 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1037911004695 CPxP motif; other site 1037911004696 multidrug efflux protein; Reviewed; Region: PRK01766 1037911004697 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1037911004698 cation binding site [ion binding]; other site 1037911004699 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1037911004700 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1037911004701 ligand binding site [chemical binding]; other site 1037911004702 NAD binding site [chemical binding]; other site 1037911004703 catalytic site [active] 1037911004704 homodimer interface [polypeptide binding]; other site 1037911004705 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1037911004706 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1037911004707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911004708 Walker A/P-loop; other site 1037911004709 ATP binding site [chemical binding]; other site 1037911004710 Q-loop/lid; other site 1037911004711 ABC transporter signature motif; other site 1037911004712 Walker B; other site 1037911004713 D-loop; other site 1037911004714 H-loop/switch region; other site 1037911004715 lytic murein transglycosylase; Provisional; Region: PRK11619 1037911004716 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1037911004717 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1037911004718 catalytic residue [active] 1037911004719 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1037911004720 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911004721 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911004722 ABC transporter; Region: ABC_tran_2; pfam12848 1037911004723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911004724 Walker A/P-loop; other site 1037911004725 ATP binding site [chemical binding]; other site 1037911004726 ABC transporter; Region: ABC_tran; pfam00005 1037911004727 Q-loop/lid; other site 1037911004728 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1037911004729 Ligand Binding Site [chemical binding]; other site 1037911004730 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1037911004731 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911004732 substrate binding site [chemical binding]; other site 1037911004733 oxyanion hole (OAH) forming residues; other site 1037911004734 trimer interface [polypeptide binding]; other site 1037911004735 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1037911004736 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1037911004737 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1037911004738 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1037911004739 dimer interface [polypeptide binding]; other site 1037911004740 active site 1037911004741 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1037911004742 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1037911004743 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1037911004744 active site 1037911004745 interdomain interaction site; other site 1037911004746 putative metal-binding site [ion binding]; other site 1037911004747 nucleotide binding site [chemical binding]; other site 1037911004748 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1037911004749 domain I; other site 1037911004750 DNA binding groove [nucleotide binding] 1037911004751 phosphate binding site [ion binding]; other site 1037911004752 domain II; other site 1037911004753 domain III; other site 1037911004754 nucleotide binding site [chemical binding]; other site 1037911004755 catalytic site [active] 1037911004756 domain IV; other site 1037911004757 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1037911004758 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1037911004759 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1037911004760 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1037911004761 Cell division inhibitor SulA; Region: SulA; cl01880 1037911004762 LexA repressor; Validated; Region: PRK00215 1037911004763 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1037911004764 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1037911004765 Catalytic site [active] 1037911004766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911004767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911004768 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1037911004769 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1037911004770 beta-hexosaminidase; Provisional; Region: PRK05337 1037911004771 SWIM zinc finger; Region: SWIM; pfam04434 1037911004772 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1037911004773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911004774 ATP binding site [chemical binding]; other site 1037911004775 putative Mg++ binding site [ion binding]; other site 1037911004776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911004777 nucleotide binding region [chemical binding]; other site 1037911004778 ATP-binding site [chemical binding]; other site 1037911004779 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1037911004780 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1037911004781 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1037911004782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911004783 ATP binding site [chemical binding]; other site 1037911004784 putative Mg++ binding site [ion binding]; other site 1037911004785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911004786 nucleotide binding region [chemical binding]; other site 1037911004787 ATP-binding site [chemical binding]; other site 1037911004788 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1037911004789 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1037911004790 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1037911004791 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1037911004792 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1037911004793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911004794 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1037911004795 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1037911004796 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1037911004797 active site 1037911004798 catalytic site [active] 1037911004799 PilZ domain; Region: PilZ; pfam07238 1037911004800 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1037911004801 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1037911004802 FtsX-like permease family; Region: FtsX; pfam02687 1037911004803 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1037911004804 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1037911004805 Walker A/P-loop; other site 1037911004806 ATP binding site [chemical binding]; other site 1037911004807 Q-loop/lid; other site 1037911004808 ABC transporter signature motif; other site 1037911004809 Walker B; other site 1037911004810 D-loop; other site 1037911004811 H-loop/switch region; other site 1037911004812 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1037911004813 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1037911004814 FtsX-like permease family; Region: FtsX; pfam02687 1037911004815 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1037911004816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911004817 dimerization interface [polypeptide binding]; other site 1037911004818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911004819 dimer interface [polypeptide binding]; other site 1037911004820 phosphorylation site [posttranslational modification] 1037911004821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911004822 ATP binding site [chemical binding]; other site 1037911004823 Mg2+ binding site [ion binding]; other site 1037911004824 G-X-G motif; other site 1037911004825 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1037911004826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911004827 active site 1037911004828 phosphorylation site [posttranslational modification] 1037911004829 intermolecular recognition site; other site 1037911004830 dimerization interface [polypeptide binding]; other site 1037911004831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911004832 DNA binding site [nucleotide binding] 1037911004833 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1037911004834 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1037911004835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1037911004836 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1037911004837 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1037911004838 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1037911004839 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1037911004840 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 1037911004841 PilZ domain; Region: PilZ; pfam07238 1037911004842 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911004843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911004844 active site 1037911004845 phosphorylation site [posttranslational modification] 1037911004846 intermolecular recognition site; other site 1037911004847 dimerization interface [polypeptide binding]; other site 1037911004848 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1037911004849 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1037911004850 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1037911004851 anti sigma factor interaction site; other site 1037911004852 regulatory phosphorylation site [posttranslational modification]; other site 1037911004853 transaldolase-like protein; Provisional; Region: PTZ00411 1037911004854 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1037911004855 active site 1037911004856 dimer interface [polypeptide binding]; other site 1037911004857 catalytic residue [active] 1037911004858 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1037911004859 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1037911004860 FMN binding site [chemical binding]; other site 1037911004861 active site 1037911004862 catalytic residues [active] 1037911004863 substrate binding site [chemical binding]; other site 1037911004864 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1037911004865 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1037911004866 active site 1037911004867 DNA binding site [nucleotide binding] 1037911004868 Int/Topo IB signature motif; other site 1037911004869 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 1037911004870 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1037911004871 active site 1037911004872 metal binding site [ion binding]; metal-binding site 1037911004873 interdomain interaction site; other site 1037911004874 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1037911004875 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1037911004876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911004877 non-specific DNA binding site [nucleotide binding]; other site 1037911004878 salt bridge; other site 1037911004879 sequence-specific DNA binding site [nucleotide binding]; other site 1037911004880 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1037911004881 tail protein; Provisional; Region: D; PHA02561 1037911004882 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1037911004883 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1037911004884 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1037911004885 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1037911004886 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1037911004887 major tail tube protein; Provisional; Region: FII; PHA02600 1037911004888 major tail sheath protein; Provisional; Region: FI; PHA02560 1037911004889 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1037911004890 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1037911004891 baseplate assembly protein; Provisional; Region: J; PHA02568 1037911004892 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1037911004893 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1037911004894 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1037911004895 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1037911004896 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1037911004897 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1037911004898 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1037911004899 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1037911004900 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 1037911004901 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1037911004902 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1037911004903 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1037911004904 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1037911004905 capsid protein; Provisional; Region: N; PHA02538 1037911004906 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1037911004907 terminase ATPase subunit; Provisional; Region: P; PHA02535 1037911004908 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1037911004909 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1037911004910 portal vertex protein; Provisional; Region: Q; PHA02536 1037911004911 Phage portal protein; Region: Phage_portal; pfam04860 1037911004912 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1037911004913 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1037911004914 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911004915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911004916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1037911004917 Coenzyme A binding pocket [chemical binding]; other site 1037911004918 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1037911004919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1037911004920 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1037911004921 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1037911004922 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1037911004923 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1037911004924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1037911004925 Transposase; Region: HTH_Tnp_1; pfam01527 1037911004926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1037911004927 Helix-turn-helix; Region: HTH_3; pfam01381 1037911004928 sequence-specific DNA binding site [nucleotide binding]; other site 1037911004929 salt bridge; other site 1037911004930 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1037911004931 Predicted transcriptional regulator [Transcription]; Region: COG3905 1037911004932 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1037911004933 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1037911004934 cofactor binding site; other site 1037911004935 DNA binding site [nucleotide binding] 1037911004936 substrate interaction site [chemical binding]; other site 1037911004937 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1037911004938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004939 putative substrate translocation pore; other site 1037911004940 malate:quinone oxidoreductase; Validated; Region: PRK05257 1037911004941 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1037911004942 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1037911004943 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1037911004944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004946 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1037911004947 putative effector binding pocket; other site 1037911004948 putative dimerization interface [polypeptide binding]; other site 1037911004949 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1037911004950 putative active site [active] 1037911004951 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1037911004952 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1037911004953 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1037911004954 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1037911004955 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1037911004956 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1037911004957 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1037911004958 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1037911004959 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1037911004960 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1037911004961 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1037911004962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911004963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004964 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1037911004965 putative effector binding pocket; other site 1037911004966 putative dimerization interface [polypeptide binding]; other site 1037911004967 acetylornithine aminotransferase; Provisional; Region: PRK02627 1037911004968 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911004969 inhibitor-cofactor binding pocket; inhibition site 1037911004970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911004971 catalytic residue [active] 1037911004972 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1037911004973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911004974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911004975 dimerization interface [polypeptide binding]; other site 1037911004976 putative transporter; Provisional; Region: PRK11043 1037911004977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911004978 putative substrate translocation pore; other site 1037911004979 xanthine permease; Region: pbuX; TIGR03173 1037911004980 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1037911004981 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911004982 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1037911004983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911004984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911004985 DNA binding residues [nucleotide binding] 1037911004986 dimerization interface [polypeptide binding]; other site 1037911004987 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911004988 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1037911004989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911004990 dimer interface [polypeptide binding]; other site 1037911004991 conserved gate region; other site 1037911004992 putative PBP binding loops; other site 1037911004993 ABC-ATPase subunit interface; other site 1037911004994 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1037911004995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911004996 dimer interface [polypeptide binding]; other site 1037911004997 conserved gate region; other site 1037911004998 putative PBP binding loops; other site 1037911004999 ABC-ATPase subunit interface; other site 1037911005000 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1037911005001 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1037911005002 Walker A/P-loop; other site 1037911005003 ATP binding site [chemical binding]; other site 1037911005004 Q-loop/lid; other site 1037911005005 ABC transporter signature motif; other site 1037911005006 Walker B; other site 1037911005007 D-loop; other site 1037911005008 H-loop/switch region; other site 1037911005009 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1037911005010 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1037911005011 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1037911005012 Walker A/P-loop; other site 1037911005013 ATP binding site [chemical binding]; other site 1037911005014 Q-loop/lid; other site 1037911005015 ABC transporter signature motif; other site 1037911005016 Walker B; other site 1037911005017 D-loop; other site 1037911005018 H-loop/switch region; other site 1037911005019 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1037911005020 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1037911005021 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1037911005022 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1037911005023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911005024 NAD(P) binding site [chemical binding]; other site 1037911005025 active site 1037911005026 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1037911005027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911005028 motif II; other site 1037911005029 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1037911005030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911005031 S-adenosylmethionine binding site [chemical binding]; other site 1037911005032 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1037911005033 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1037911005034 active site 1037911005035 putative substrate binding pocket [chemical binding]; other site 1037911005036 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1037911005037 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1037911005038 DNA gyrase subunit A; Validated; Region: PRK05560 1037911005039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1037911005040 CAP-like domain; other site 1037911005041 active site 1037911005042 primary dimer interface [polypeptide binding]; other site 1037911005043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1037911005044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1037911005045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1037911005046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1037911005047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1037911005048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1037911005049 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1037911005050 homodimer interface [polypeptide binding]; other site 1037911005051 substrate-cofactor binding pocket; other site 1037911005052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911005053 catalytic residue [active] 1037911005054 Chorismate mutase type II; Region: CM_2; cl00693 1037911005055 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1037911005056 Prephenate dehydratase; Region: PDT; pfam00800 1037911005057 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1037911005058 putative L-Phe binding site [chemical binding]; other site 1037911005059 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1037911005060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911005061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911005062 homodimer interface [polypeptide binding]; other site 1037911005063 catalytic residue [active] 1037911005064 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1037911005065 prephenate dehydrogenase; Validated; Region: PRK08507 1037911005066 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1037911005067 hinge; other site 1037911005068 active site 1037911005069 cytidylate kinase; Provisional; Region: cmk; PRK00023 1037911005070 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1037911005071 CMP-binding site; other site 1037911005072 The sites determining sugar specificity; other site 1037911005073 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1037911005074 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1037911005075 RNA binding site [nucleotide binding]; other site 1037911005076 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1037911005077 RNA binding site [nucleotide binding]; other site 1037911005078 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1037911005079 RNA binding site [nucleotide binding]; other site 1037911005080 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1037911005081 RNA binding site [nucleotide binding]; other site 1037911005082 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1037911005083 RNA binding site [nucleotide binding]; other site 1037911005084 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1037911005085 RNA binding site [nucleotide binding]; other site 1037911005086 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1037911005087 IHF dimer interface [polypeptide binding]; other site 1037911005088 IHF - DNA interface [nucleotide binding]; other site 1037911005089 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1037911005090 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1037911005091 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1037911005092 substrate binding site; other site 1037911005093 tetramer interface; other site 1037911005094 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1037911005095 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1037911005096 inhibitor-cofactor binding pocket; inhibition site 1037911005097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911005098 catalytic residue [active] 1037911005099 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1037911005100 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911005101 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1037911005102 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1037911005103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911005104 NAD(P) binding site [chemical binding]; other site 1037911005105 active site 1037911005106 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911005107 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1037911005108 putative ADP-binding pocket [chemical binding]; other site 1037911005109 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1037911005110 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1037911005111 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1037911005112 putative trimer interface [polypeptide binding]; other site 1037911005113 putative CoA binding site [chemical binding]; other site 1037911005114 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1037911005115 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1037911005116 inhibitor-cofactor binding pocket; inhibition site 1037911005117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911005118 catalytic residue [active] 1037911005119 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1037911005120 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1037911005121 NAD(P) binding site [chemical binding]; other site 1037911005122 homodimer interface [polypeptide binding]; other site 1037911005123 substrate binding site [chemical binding]; other site 1037911005124 active site 1037911005125 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1037911005126 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1037911005127 trimer interface [polypeptide binding]; other site 1037911005128 active site 1037911005129 substrate binding site [chemical binding]; other site 1037911005130 CoA binding site [chemical binding]; other site 1037911005131 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1037911005132 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1037911005133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911005134 DNA-binding site [nucleotide binding]; DNA binding site 1037911005135 FCD domain; Region: FCD; pfam07729 1037911005136 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1037911005137 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1037911005138 ethanolamine permease; Region: 2A0305; TIGR00908 1037911005139 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1037911005140 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1037911005141 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1037911005142 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1037911005143 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1037911005144 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1037911005145 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1037911005146 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1037911005147 Ligand Binding Site [chemical binding]; other site 1037911005148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911005149 dimer interface [polypeptide binding]; other site 1037911005150 phosphorylation site [posttranslational modification] 1037911005151 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1037911005152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911005153 active site 1037911005154 phosphorylation site [posttranslational modification] 1037911005155 intermolecular recognition site; other site 1037911005156 dimerization interface [polypeptide binding]; other site 1037911005157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911005158 DNA binding site [nucleotide binding] 1037911005159 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1037911005160 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1037911005161 active site 1037911005162 nucleophile elbow; other site 1037911005163 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1037911005164 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1037911005165 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1037911005166 active site 1037911005167 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1037911005168 active site 2 [active] 1037911005169 active site 1 [active] 1037911005170 Protein of unknown function (DUF962); Region: DUF962; cl01879 1037911005171 Terminase small subunit; Region: Terminase_2; cl01513 1037911005172 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1037911005173 RHS Repeat; Region: RHS_repeat; pfam05593 1037911005174 RHS Repeat; Region: RHS_repeat; pfam05593 1037911005175 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1037911005176 RHS Repeat; Region: RHS_repeat; pfam05593 1037911005177 RHS Repeat; Region: RHS_repeat; pfam05593 1037911005178 RHS Repeat; Region: RHS_repeat; pfam05593 1037911005179 RHS protein; Region: RHS; pfam03527 1037911005180 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1037911005181 ParB-like nuclease domain; Region: ParBc; pfam02195 1037911005182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911005183 dimerization interface [polypeptide binding]; other site 1037911005184 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911005185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911005186 dimer interface [polypeptide binding]; other site 1037911005187 putative CheW interface [polypeptide binding]; other site 1037911005188 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1037911005189 active site 1037911005190 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1037911005191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911005192 substrate binding pocket [chemical binding]; other site 1037911005193 membrane-bound complex binding site; other site 1037911005194 hinge residues; other site 1037911005195 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1037911005196 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1037911005197 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1037911005198 catalytic residue [active] 1037911005199 Predicted membrane protein [Function unknown]; Region: COG2259 1037911005200 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1037911005201 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1037911005202 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1037911005203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911005204 Walker A/P-loop; other site 1037911005205 ATP binding site [chemical binding]; other site 1037911005206 Q-loop/lid; other site 1037911005207 ABC transporter signature motif; other site 1037911005208 Walker B; other site 1037911005209 D-loop; other site 1037911005210 H-loop/switch region; other site 1037911005211 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1037911005212 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1037911005213 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1037911005214 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1037911005215 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1037911005216 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1037911005217 Walker A/P-loop; other site 1037911005218 ATP binding site [chemical binding]; other site 1037911005219 Q-loop/lid; other site 1037911005220 ABC transporter signature motif; other site 1037911005221 Walker B; other site 1037911005222 D-loop; other site 1037911005223 H-loop/switch region; other site 1037911005224 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1037911005225 active site 1037911005226 catalytic triad [active] 1037911005227 oxyanion hole [active] 1037911005228 switch loop; other site 1037911005229 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1037911005230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911005231 Coenzyme A binding pocket [chemical binding]; other site 1037911005232 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1037911005233 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1037911005234 PilZ domain; Region: PilZ; pfam07238 1037911005235 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1037911005236 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1037911005237 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1037911005238 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1037911005239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1037911005240 Ligand Binding Site [chemical binding]; other site 1037911005241 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1037911005242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911005243 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1037911005244 substrate binding site [chemical binding]; other site 1037911005245 dimerization interface [polypeptide binding]; other site 1037911005246 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1037911005247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1037911005248 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1037911005249 elongation factor P; Validated; Region: PRK00529 1037911005250 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1037911005251 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1037911005252 RNA binding site [nucleotide binding]; other site 1037911005253 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1037911005254 RNA binding site [nucleotide binding]; other site 1037911005255 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1037911005256 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1037911005257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911005258 putative Zn2+ binding site [ion binding]; other site 1037911005259 putative DNA binding site [nucleotide binding]; other site 1037911005260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911005261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911005262 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911005263 putative effector binding pocket; other site 1037911005264 dimerization interface [polypeptide binding]; other site 1037911005265 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1037911005266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911005267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911005268 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911005269 dimerization interface [polypeptide binding]; other site 1037911005270 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1037911005271 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1037911005272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911005273 enoyl-CoA hydratase; Provisional; Region: PRK06563 1037911005274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911005275 substrate binding site [chemical binding]; other site 1037911005276 oxyanion hole (OAH) forming residues; other site 1037911005277 trimer interface [polypeptide binding]; other site 1037911005278 helicase 45; Provisional; Region: PTZ00424 1037911005279 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1037911005280 ATP binding site [chemical binding]; other site 1037911005281 Mg++ binding site [ion binding]; other site 1037911005282 motif III; other site 1037911005283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911005284 nucleotide binding region [chemical binding]; other site 1037911005285 ATP-binding site [chemical binding]; other site 1037911005286 DbpA RNA binding domain; Region: DbpA; pfam03880 1037911005287 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1037911005288 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1037911005289 putative active site [active] 1037911005290 metal binding site [ion binding]; metal-binding site 1037911005291 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 1037911005292 heat shock protein HtpX; Provisional; Region: PRK05457 1037911005293 aminotransferase AlaT; Validated; Region: PRK09265 1037911005294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911005295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911005296 homodimer interface [polypeptide binding]; other site 1037911005297 catalytic residue [active] 1037911005298 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1037911005299 SelR domain; Region: SelR; pfam01641 1037911005300 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1037911005301 catalytic residues [active] 1037911005302 dimer interface [polypeptide binding]; other site 1037911005303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911005304 dimer interface [polypeptide binding]; other site 1037911005305 phosphorylation site [posttranslational modification] 1037911005306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911005307 ATP binding site [chemical binding]; other site 1037911005308 Mg2+ binding site [ion binding]; other site 1037911005309 G-X-G motif; other site 1037911005310 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911005311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911005312 active site 1037911005313 phosphorylation site [posttranslational modification] 1037911005314 intermolecular recognition site; other site 1037911005315 dimerization interface [polypeptide binding]; other site 1037911005316 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1037911005317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911005318 Walker A motif; other site 1037911005319 ATP binding site [chemical binding]; other site 1037911005320 Walker B motif; other site 1037911005321 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1037911005322 GAF domain; Region: GAF_2; pfam13185 1037911005323 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1037911005324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911005325 substrate binding pocket [chemical binding]; other site 1037911005326 membrane-bound complex binding site; other site 1037911005327 hinge residues; other site 1037911005328 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911005329 substrate binding pocket [chemical binding]; other site 1037911005330 membrane-bound complex binding site; other site 1037911005331 hinge residues; other site 1037911005332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911005333 putative active site [active] 1037911005334 heme pocket [chemical binding]; other site 1037911005335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911005336 dimer interface [polypeptide binding]; other site 1037911005337 phosphorylation site [posttranslational modification] 1037911005338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911005339 ATP binding site [chemical binding]; other site 1037911005340 Mg2+ binding site [ion binding]; other site 1037911005341 G-X-G motif; other site 1037911005342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911005343 active site 1037911005344 phosphorylation site [posttranslational modification] 1037911005345 intermolecular recognition site; other site 1037911005346 dimerization interface [polypeptide binding]; other site 1037911005347 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911005348 putative binding surface; other site 1037911005349 active site 1037911005350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911005351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911005352 active site 1037911005353 phosphorylation site [posttranslational modification] 1037911005354 intermolecular recognition site; other site 1037911005355 dimerization interface [polypeptide binding]; other site 1037911005356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911005357 DNA binding residues [nucleotide binding] 1037911005358 dimerization interface [polypeptide binding]; other site 1037911005359 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911005360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911005361 active site 1037911005362 phosphorylation site [posttranslational modification] 1037911005363 intermolecular recognition site; other site 1037911005364 dimerization interface [polypeptide binding]; other site 1037911005365 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1037911005366 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1037911005367 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1037911005368 Predicted membrane protein [Function unknown]; Region: COG5393 1037911005369 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1037911005370 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1037911005371 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1037911005372 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1037911005373 TrkA-N domain; Region: TrkA_N; pfam02254 1037911005374 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1037911005375 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1037911005376 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1037911005377 active site 1037911005378 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1037911005379 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1037911005380 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1037911005381 GTP binding site; other site 1037911005382 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1037911005383 MPT binding site; other site 1037911005384 trimer interface [polypeptide binding]; other site 1037911005385 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1037911005386 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1037911005387 dimer interface [polypeptide binding]; other site 1037911005388 putative functional site; other site 1037911005389 putative MPT binding site; other site 1037911005390 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1037911005391 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1037911005392 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1037911005393 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1037911005394 Walker A/P-loop; other site 1037911005395 ATP binding site [chemical binding]; other site 1037911005396 Q-loop/lid; other site 1037911005397 ABC transporter signature motif; other site 1037911005398 Walker B; other site 1037911005399 D-loop; other site 1037911005400 H-loop/switch region; other site 1037911005401 CcmB protein; Region: CcmB; cl17444 1037911005402 CcmB protein; Region: CcmB; cl17444 1037911005403 heme exporter protein CcmC; Region: ccmC; TIGR01191 1037911005404 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1037911005405 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1037911005406 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1037911005407 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1037911005408 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1037911005409 catalytic residues [active] 1037911005410 central insert; other site 1037911005411 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1037911005412 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1037911005413 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1037911005414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911005415 binding surface 1037911005416 TPR motif; other site 1037911005417 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1037911005418 Guanylate kinase; Region: Guanylate_kin; pfam00625 1037911005419 active site 1037911005420 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1037911005421 active site 1037911005422 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1037911005423 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1037911005424 active site 1037911005425 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1037911005426 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1037911005427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911005428 putative substrate translocation pore; other site 1037911005429 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1037911005430 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1037911005431 Ion transport protein; Region: Ion_trans; pfam00520 1037911005432 Ion channel; Region: Ion_trans_2; pfam07885 1037911005433 Urea transporter; Region: UT; pfam03253 1037911005434 pyruvate kinase; Provisional; Region: PRK06247 1037911005435 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1037911005436 domain interfaces; other site 1037911005437 active site 1037911005438 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1037911005439 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1037911005440 MOFRL family; Region: MOFRL; pfam05161 1037911005441 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1037911005442 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1037911005443 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1037911005444 glyoxylate carboligase; Provisional; Region: PRK11269 1037911005445 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1037911005446 PYR/PP interface [polypeptide binding]; other site 1037911005447 dimer interface [polypeptide binding]; other site 1037911005448 TPP binding site [chemical binding]; other site 1037911005449 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1037911005450 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1037911005451 TPP-binding site [chemical binding]; other site 1037911005452 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1037911005453 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1037911005454 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1037911005455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911005456 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1037911005457 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1037911005458 VacJ like lipoprotein; Region: VacJ; cl01073 1037911005459 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1037911005460 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1037911005461 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1037911005462 Predicted membrane protein [Function unknown]; Region: COG3162 1037911005463 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1037911005464 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1037911005465 Na binding site [ion binding]; other site 1037911005466 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1037911005467 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1037911005468 dimer interface [polypeptide binding]; other site 1037911005469 active site 1037911005470 citrylCoA binding site [chemical binding]; other site 1037911005471 NADH binding [chemical binding]; other site 1037911005472 cationic pore residues; other site 1037911005473 oxalacetate/citrate binding site [chemical binding]; other site 1037911005474 coenzyme A binding site [chemical binding]; other site 1037911005475 catalytic triad [active] 1037911005476 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1037911005477 Iron-sulfur protein interface; other site 1037911005478 proximal quinone binding site [chemical binding]; other site 1037911005479 SdhD (CybS) interface [polypeptide binding]; other site 1037911005480 proximal heme binding site [chemical binding]; other site 1037911005481 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1037911005482 SdhC subunit interface [polypeptide binding]; other site 1037911005483 proximal heme binding site [chemical binding]; other site 1037911005484 cardiolipin binding site; other site 1037911005485 Iron-sulfur protein interface; other site 1037911005486 proximal quinone binding site [chemical binding]; other site 1037911005487 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 1037911005488 L-aspartate oxidase; Provisional; Region: PRK06175 1037911005489 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1037911005490 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1037911005491 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1037911005492 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1037911005493 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1037911005494 TPP-binding site [chemical binding]; other site 1037911005495 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1037911005496 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1037911005497 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1037911005498 E3 interaction surface; other site 1037911005499 lipoyl attachment site [posttranslational modification]; other site 1037911005500 e3 binding domain; Region: E3_binding; pfam02817 1037911005501 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1037911005502 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1037911005503 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1037911005504 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911005505 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1037911005506 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1037911005507 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1037911005508 CoA-ligase; Region: Ligase_CoA; pfam00549 1037911005509 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1037911005510 CoA binding domain; Region: CoA_binding; pfam02629 1037911005511 CoA-ligase; Region: Ligase_CoA; pfam00549 1037911005512 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1037911005513 Predicted membrane protein [Function unknown]; Region: COG3821 1037911005514 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1037911005515 CoenzymeA binding site [chemical binding]; other site 1037911005516 subunit interaction site [polypeptide binding]; other site 1037911005517 PHB binding site; other site 1037911005518 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1037911005519 CoenzymeA binding site [chemical binding]; other site 1037911005520 subunit interaction site [polypeptide binding]; other site 1037911005521 PHB binding site; other site 1037911005522 heat shock protein 90; Provisional; Region: PRK05218 1037911005523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911005524 ATP binding site [chemical binding]; other site 1037911005525 Mg2+ binding site [ion binding]; other site 1037911005526 G-X-G motif; other site 1037911005527 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1037911005528 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1037911005529 Pirin-related protein [General function prediction only]; Region: COG1741 1037911005530 Pirin; Region: Pirin; pfam02678 1037911005531 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1037911005532 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1037911005533 Amidohydrolase; Region: Amidohydro_2; pfam04909 1037911005534 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1037911005535 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1037911005536 HAMP domain; Region: HAMP; pfam00672 1037911005537 dimerization interface [polypeptide binding]; other site 1037911005538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911005539 dimer interface [polypeptide binding]; other site 1037911005540 putative CheW interface [polypeptide binding]; other site 1037911005541 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1037911005542 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1037911005543 dimer interface [polypeptide binding]; other site 1037911005544 active site 1037911005545 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1037911005546 active site 1 [active] 1037911005547 dimer interface [polypeptide binding]; other site 1037911005548 active site 2 [active] 1037911005549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911005550 dimerization interface [polypeptide binding]; other site 1037911005551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911005552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911005553 dimer interface [polypeptide binding]; other site 1037911005554 phosphorylation site [posttranslational modification] 1037911005555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911005556 ATP binding site [chemical binding]; other site 1037911005557 Mg2+ binding site [ion binding]; other site 1037911005558 G-X-G motif; other site 1037911005559 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911005560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911005561 active site 1037911005562 phosphorylation site [posttranslational modification] 1037911005563 intermolecular recognition site; other site 1037911005564 dimerization interface [polypeptide binding]; other site 1037911005565 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1037911005566 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1037911005567 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1037911005568 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1037911005569 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1037911005570 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1037911005571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1037911005572 catalytic core [active] 1037911005573 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1037911005574 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 1037911005575 acyl-activating enzyme (AAE) consensus motif; other site 1037911005576 putative AMP binding site [chemical binding]; other site 1037911005577 putative active site [active] 1037911005578 putative CoA binding site [chemical binding]; other site 1037911005579 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1037911005580 CoenzymeA binding site [chemical binding]; other site 1037911005581 subunit interaction site [polypeptide binding]; other site 1037911005582 PHB binding site; other site 1037911005583 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911005584 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911005585 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1037911005586 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1037911005587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911005588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911005589 dimerization interface [polypeptide binding]; other site 1037911005590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911005591 dimer interface [polypeptide binding]; other site 1037911005592 phosphorylation site [posttranslational modification] 1037911005593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911005594 ATP binding site [chemical binding]; other site 1037911005595 Mg2+ binding site [ion binding]; other site 1037911005596 G-X-G motif; other site 1037911005597 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911005598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911005599 active site 1037911005600 phosphorylation site [posttranslational modification] 1037911005601 intermolecular recognition site; other site 1037911005602 dimerization interface [polypeptide binding]; other site 1037911005603 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911005604 DNA binding site [nucleotide binding] 1037911005605 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1037911005606 active site 1037911005607 dimer interface [polypeptide binding]; other site 1037911005608 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1037911005609 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1037911005610 NAD(P) binding site [chemical binding]; other site 1037911005611 substrate binding site [chemical binding]; other site 1037911005612 dimer interface [polypeptide binding]; other site 1037911005613 short chain dehydrogenase; Provisional; Region: PRK06172 1037911005614 classical (c) SDRs; Region: SDR_c; cd05233 1037911005615 NAD(P) binding site [chemical binding]; other site 1037911005616 active site 1037911005617 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911005618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911005619 DNA-binding site [nucleotide binding]; DNA binding site 1037911005620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911005621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911005622 homodimer interface [polypeptide binding]; other site 1037911005623 catalytic residue [active] 1037911005624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911005625 dimerization interface [polypeptide binding]; other site 1037911005626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911005627 dimer interface [polypeptide binding]; other site 1037911005628 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911005629 putative CheW interface [polypeptide binding]; other site 1037911005630 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911005631 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911005632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911005633 DNA binding residues [nucleotide binding] 1037911005634 dimerization interface [polypeptide binding]; other site 1037911005635 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1037911005636 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911005637 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1037911005638 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911005639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911005640 DNA-binding site [nucleotide binding]; DNA binding site 1037911005641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911005642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911005643 homodimer interface [polypeptide binding]; other site 1037911005644 catalytic residue [active] 1037911005645 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1037911005646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911005647 catalytic loop [active] 1037911005648 iron binding site [ion binding]; other site 1037911005649 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1037911005650 FAD binding pocket [chemical binding]; other site 1037911005651 conserved FAD binding motif [chemical binding]; other site 1037911005652 phosphate binding motif [ion binding]; other site 1037911005653 beta-alpha-beta structure motif; other site 1037911005654 NAD binding pocket [chemical binding]; other site 1037911005655 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1037911005656 active site 1037911005657 hypothetical protein; Provisional; Region: PRK06156 1037911005658 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1037911005659 metal binding site [ion binding]; metal-binding site 1037911005660 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 1037911005661 PLD-like domain; Region: PLDc_2; pfam13091 1037911005662 putative active site [active] 1037911005663 putative catalytic site [active] 1037911005664 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 1037911005665 PLD-like domain; Region: PLDc_2; pfam13091 1037911005666 putative active site [active] 1037911005667 putative catalytic site [active] 1037911005668 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1037911005669 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911005670 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911005671 N-terminal plug; other site 1037911005672 ligand-binding site [chemical binding]; other site 1037911005673 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1037911005674 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1037911005675 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1037911005676 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1037911005677 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1037911005678 PhoD-like phosphatase; Region: PhoD; pfam09423 1037911005679 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1037911005680 putative active site [active] 1037911005681 putative metal binding site [ion binding]; other site 1037911005682 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1037911005683 alanine-tRNA ligase; Region: PLN02961 1037911005684 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1037911005685 transcriptional activator TtdR; Provisional; Region: PRK09801 1037911005686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911005687 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911005688 putative effector binding pocket; other site 1037911005689 dimerization interface [polypeptide binding]; other site 1037911005690 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1037911005691 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1037911005692 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1037911005693 active site 1037911005694 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1037911005695 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1037911005696 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1037911005697 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911005698 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1037911005699 putative C-terminal domain interface [polypeptide binding]; other site 1037911005700 putative GSH binding site (G-site) [chemical binding]; other site 1037911005701 putative dimer interface [polypeptide binding]; other site 1037911005702 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1037911005703 putative N-terminal domain interface [polypeptide binding]; other site 1037911005704 putative dimer interface [polypeptide binding]; other site 1037911005705 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911005706 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1037911005707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911005708 Walker A/P-loop; other site 1037911005709 ATP binding site [chemical binding]; other site 1037911005710 Q-loop/lid; other site 1037911005711 ABC transporter signature motif; other site 1037911005712 Walker B; other site 1037911005713 D-loop; other site 1037911005714 H-loop/switch region; other site 1037911005715 inner membrane transport permease; Provisional; Region: PRK15066 1037911005716 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1037911005717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911005718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911005719 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 1037911005720 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1037911005721 gating phenylalanine in ion channel; other site 1037911005722 H+ Antiporter protein; Region: 2A0121; TIGR00900 1037911005723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911005724 putative substrate translocation pore; other site 1037911005725 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1037911005726 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1037911005727 putative acyl-acceptor binding pocket; other site 1037911005728 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1037911005729 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1037911005730 RTX N-terminal domain; Region: RTX; pfam02382 1037911005731 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1037911005732 Sodium Bile acid symporter family; Region: SBF; cl17470 1037911005733 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1037911005734 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1037911005735 putative heme binding pocket [chemical binding]; other site 1037911005736 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1037911005737 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1037911005738 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1037911005739 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1037911005740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911005741 non-specific DNA binding site [nucleotide binding]; other site 1037911005742 salt bridge; other site 1037911005743 sequence-specific DNA binding site [nucleotide binding]; other site 1037911005744 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911005745 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1037911005746 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911005747 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911005748 metal binding site [ion binding]; metal-binding site 1037911005749 active site 1037911005750 I-site; other site 1037911005751 carboxy-terminal protease; Provisional; Region: PRK11186 1037911005752 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1037911005753 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1037911005754 protein binding site [polypeptide binding]; other site 1037911005755 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1037911005756 Catalytic dyad [active] 1037911005757 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1037911005758 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1037911005759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911005760 motif II; other site 1037911005761 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1037911005762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911005763 Walker A/P-loop; other site 1037911005764 ATP binding site [chemical binding]; other site 1037911005765 Q-loop/lid; other site 1037911005766 ABC transporter signature motif; other site 1037911005767 Walker B; other site 1037911005768 D-loop; other site 1037911005769 H-loop/switch region; other site 1037911005770 TOBE domain; Region: TOBE_2; pfam08402 1037911005771 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1037911005772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911005773 dimer interface [polypeptide binding]; other site 1037911005774 conserved gate region; other site 1037911005775 ABC-ATPase subunit interface; other site 1037911005776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911005777 dimer interface [polypeptide binding]; other site 1037911005778 conserved gate region; other site 1037911005779 putative PBP binding loops; other site 1037911005780 ABC-ATPase subunit interface; other site 1037911005781 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1037911005782 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 1037911005783 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1037911005784 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1037911005785 transcriptional regulator protein; Region: phnR; TIGR03337 1037911005786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911005787 DNA-binding site [nucleotide binding]; DNA binding site 1037911005788 UTRA domain; Region: UTRA; pfam07702 1037911005789 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1037911005790 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1037911005791 intersubunit interface [polypeptide binding]; other site 1037911005792 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1037911005793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1037911005794 ABC-ATPase subunit interface; other site 1037911005795 dimer interface [polypeptide binding]; other site 1037911005796 putative PBP binding regions; other site 1037911005797 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1037911005798 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1037911005799 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1037911005800 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1037911005801 metal binding site [ion binding]; metal-binding site 1037911005802 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1037911005803 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1037911005804 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1037911005805 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1037911005806 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1037911005807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911005808 FeS/SAM binding site; other site 1037911005809 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1037911005810 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1037911005811 H+ Antiporter protein; Region: 2A0121; TIGR00900 1037911005812 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1037911005813 putative dimer interface [polypeptide binding]; other site 1037911005814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911005815 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1037911005816 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1037911005817 DNA binding residues [nucleotide binding] 1037911005818 dimer interface [polypeptide binding]; other site 1037911005819 [2Fe-2S] cluster binding site [ion binding]; other site 1037911005820 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1037911005821 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1037911005822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911005823 Walker A motif; other site 1037911005824 ATP binding site [chemical binding]; other site 1037911005825 Walker B motif; other site 1037911005826 arginine finger; other site 1037911005827 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1037911005828 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1037911005829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911005830 catalytic residue [active] 1037911005831 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1037911005832 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1037911005833 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1037911005834 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1037911005835 active site 1037911005836 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1037911005837 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1037911005838 putative catalytic residue [active] 1037911005839 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1037911005840 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1037911005841 putative NAD(P) binding site [chemical binding]; other site 1037911005842 active site 1037911005843 threonine and homoserine efflux system; Provisional; Region: PRK10532 1037911005844 EamA-like transporter family; Region: EamA; pfam00892 1037911005845 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1037911005846 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1037911005847 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1037911005848 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 1037911005849 Autotransporter beta-domain; Region: Autotransporter; smart00869 1037911005850 DNA polymerase II; Reviewed; Region: PRK05762 1037911005851 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1037911005852 active site 1037911005853 catalytic site [active] 1037911005854 substrate binding site [chemical binding]; other site 1037911005855 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1037911005856 active site 1037911005857 metal-binding site 1037911005858 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911005859 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1037911005860 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1037911005861 N-terminal domain interface [polypeptide binding]; other site 1037911005862 dimer interface [polypeptide binding]; other site 1037911005863 substrate binding pocket (H-site) [chemical binding]; other site 1037911005864 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1037911005865 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1037911005866 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1037911005867 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1037911005868 trimer interface [polypeptide binding]; other site 1037911005869 active site 1037911005870 substrate binding site [chemical binding]; other site 1037911005871 CoA binding site [chemical binding]; other site 1037911005872 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1037911005873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911005874 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1037911005875 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1037911005876 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1037911005877 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1037911005878 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911005879 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1037911005880 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1037911005881 Chain length determinant protein; Region: Wzz; cl15801 1037911005882 Chain length determinant protein; Region: Wzz; cl15801 1037911005883 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1037911005884 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1037911005885 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1037911005886 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1037911005887 active site 1037911005888 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1037911005889 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1037911005890 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1037911005891 Substrate binding site; other site 1037911005892 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1037911005893 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1037911005894 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1037911005895 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1037911005896 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911005897 N-terminal plug; other site 1037911005898 ligand-binding site [chemical binding]; other site 1037911005899 fec operon regulator FecR; Reviewed; Region: PRK09774 1037911005900 FecR protein; Region: FecR; pfam04773 1037911005901 RNA polymerase sigma factor; Provisional; Region: PRK12528 1037911005902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911005903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911005904 DNA binding residues [nucleotide binding] 1037911005905 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1037911005906 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1037911005907 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1037911005908 conserved cys residue [active] 1037911005909 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911005910 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1037911005911 conserved cys residue [active] 1037911005912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911005913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911005914 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911005915 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1037911005916 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1037911005917 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1037911005918 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1037911005919 NAD binding site [chemical binding]; other site 1037911005920 homodimer interface [polypeptide binding]; other site 1037911005921 active site 1037911005922 Cytochrome c; Region: Cytochrom_C; pfam00034 1037911005923 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1037911005924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911005925 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911005926 DNA binding residues [nucleotide binding] 1037911005927 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1037911005928 FecR protein; Region: FecR; pfam04773 1037911005929 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911005930 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1037911005931 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911005932 N-terminal plug; other site 1037911005933 ligand-binding site [chemical binding]; other site 1037911005934 diaminopimelate epimerase; Provisional; Region: PRK13577 1037911005935 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1037911005936 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1037911005937 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1037911005938 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1037911005939 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1037911005940 active site flap/lid [active] 1037911005941 nucleophilic elbow; other site 1037911005942 catalytic triad [active] 1037911005943 cytosine deaminase; Provisional; Region: PRK09230 1037911005944 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1037911005945 active site 1037911005946 cytosine permease; Provisional; Region: codB; PRK11017 1037911005947 Na binding site [ion binding]; other site 1037911005948 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1037911005949 active site 1037911005950 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1037911005951 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1037911005952 putative active site [active] 1037911005953 putative NTP binding site [chemical binding]; other site 1037911005954 putative nucleic acid binding site [nucleotide binding]; other site 1037911005955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911005956 S-adenosylmethionine binding site [chemical binding]; other site 1037911005957 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1037911005958 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 1037911005959 Sporulation related domain; Region: SPOR; pfam05036 1037911005960 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1037911005961 Predicted transcriptional regulator [Transcription]; Region: COG2932 1037911005962 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1037911005963 Catalytic site [active] 1037911005964 Prophage antirepressor [Transcription]; Region: COG3617 1037911005965 BRO family, N-terminal domain; Region: Bro-N; smart01040 1037911005966 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1037911005967 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1037911005968 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1037911005969 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1037911005970 active site 1037911005971 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1037911005972 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 1037911005973 Phage terminase large subunit; Region: Terminase_3; cl12054 1037911005974 Terminase-like family; Region: Terminase_6; pfam03237 1037911005975 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 1037911005976 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1037911005977 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1037911005978 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 1037911005979 Phage tail protein; Region: Phage_tail_3; pfam08813 1037911005980 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 1037911005981 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 1037911005982 Phage-related minor tail protein [Function unknown]; Region: COG5281 1037911005983 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1037911005984 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1037911005985 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1037911005986 Phage-related protein [Function unknown]; Region: gp18; COG4672 1037911005987 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1037911005988 MPN+ (JAMM) motif; other site 1037911005989 Zinc-binding site [ion binding]; other site 1037911005990 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1037911005991 NlpC/P60 family; Region: NLPC_P60; cl17555 1037911005992 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 1037911005993 Phage-related protein, tail component [Function unknown]; Region: COG4723 1037911005994 Phage-related protein, tail component [Function unknown]; Region: COG4733 1037911005995 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1037911005996 Tissue factor; Region: Tissue_fac; pfam01108 1037911005997 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1037911005998 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1037911005999 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1037911006000 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1037911006001 RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306 1037911006002 integrase; Provisional; Region: PRK09692 1037911006003 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1037911006004 active site 1037911006005 Int/Topo IB signature motif; other site 1037911006006 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1037911006007 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1037911006008 Predicted membrane protein [Function unknown]; Region: COG3212 1037911006009 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1037911006010 Predicted membrane protein [Function unknown]; Region: COG3212 1037911006011 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1037911006012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911006013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911006014 active site 1037911006015 phosphorylation site [posttranslational modification] 1037911006016 intermolecular recognition site; other site 1037911006017 dimerization interface [polypeptide binding]; other site 1037911006018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911006019 DNA binding site [nucleotide binding] 1037911006020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911006021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911006022 ATP binding site [chemical binding]; other site 1037911006023 G-X-G motif; other site 1037911006024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911006025 dimerization interface [polypeptide binding]; other site 1037911006026 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911006027 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911006028 dimer interface [polypeptide binding]; other site 1037911006029 putative CheW interface [polypeptide binding]; other site 1037911006030 Predicted permease [General function prediction only]; Region: COG2056 1037911006031 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1037911006032 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1037911006033 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1037911006034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911006035 dimerization interface [polypeptide binding]; other site 1037911006036 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911006037 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911006038 dimer interface [polypeptide binding]; other site 1037911006039 putative CheW interface [polypeptide binding]; other site 1037911006040 putative protease; Provisional; Region: PRK15452 1037911006041 Peptidase family U32; Region: Peptidase_U32; pfam01136 1037911006042 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1037911006043 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1037911006044 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1037911006045 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1037911006046 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1037911006047 shikimate binding site; other site 1037911006048 NAD(P) binding site [chemical binding]; other site 1037911006049 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911006050 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1037911006051 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1037911006052 serine/threonine transporter SstT; Provisional; Region: PRK13628 1037911006053 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1037911006054 putative arabinose transporter; Provisional; Region: PRK03545 1037911006055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006056 putative substrate translocation pore; other site 1037911006057 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1037911006058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006059 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1037911006060 putative dimerization interface [polypeptide binding]; other site 1037911006061 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1037911006062 selenophosphate synthetase; Provisional; Region: PRK00943 1037911006063 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1037911006064 dimerization interface [polypeptide binding]; other site 1037911006065 putative ATP binding site [chemical binding]; other site 1037911006066 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1037911006067 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1037911006068 active site residue [active] 1037911006069 Predicted permease; Region: DUF318; pfam03773 1037911006070 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911006071 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1037911006072 C-terminal domain interface [polypeptide binding]; other site 1037911006073 GSH binding site (G-site) [chemical binding]; other site 1037911006074 dimer interface [polypeptide binding]; other site 1037911006075 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1037911006076 dimer interface [polypeptide binding]; other site 1037911006077 N-terminal domain interface [polypeptide binding]; other site 1037911006078 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1037911006079 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1037911006080 dimer interface [polypeptide binding]; other site 1037911006081 active site 1037911006082 Schiff base residues; other site 1037911006083 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1037911006084 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006085 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006086 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006087 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1037911006088 RHS Repeat; Region: RHS_repeat; cl11982 1037911006089 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006090 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006091 RHS protein; Region: RHS; pfam03527 1037911006092 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1037911006093 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1037911006094 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1037911006095 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1037911006096 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1037911006097 CoenzymeA binding site [chemical binding]; other site 1037911006098 subunit interaction site [polypeptide binding]; other site 1037911006099 PHB binding site; other site 1037911006100 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1037911006101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1037911006102 dimer interface [polypeptide binding]; other site 1037911006103 active site 1037911006104 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1037911006105 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1037911006106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911006107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006108 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1037911006109 putative dimerization interface [polypeptide binding]; other site 1037911006110 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1037911006111 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1037911006112 NAD+ binding site [chemical binding]; other site 1037911006113 substrate binding site [chemical binding]; other site 1037911006114 Zn binding site [ion binding]; other site 1037911006115 FOG: CBS domain [General function prediction only]; Region: COG0517 1037911006116 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1037911006117 DNA topoisomerase III; Provisional; Region: PRK07726 1037911006118 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1037911006119 active site 1037911006120 putative interdomain interaction site [polypeptide binding]; other site 1037911006121 putative metal-binding site [ion binding]; other site 1037911006122 putative nucleotide binding site [chemical binding]; other site 1037911006123 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1037911006124 domain I; other site 1037911006125 DNA binding groove [nucleotide binding] 1037911006126 phosphate binding site [ion binding]; other site 1037911006127 domain II; other site 1037911006128 domain III; other site 1037911006129 nucleotide binding site [chemical binding]; other site 1037911006130 catalytic site [active] 1037911006131 domain IV; other site 1037911006132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006133 putative substrate translocation pore; other site 1037911006134 choline dehydrogenase; Validated; Region: PRK02106 1037911006135 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1037911006136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911006137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006138 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911006139 dimerization interface [polypeptide binding]; other site 1037911006140 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1037911006141 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1037911006142 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1037911006143 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1037911006144 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1037911006145 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1037911006146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911006147 non-specific DNA binding site [nucleotide binding]; other site 1037911006148 salt bridge; other site 1037911006149 sequence-specific DNA binding site [nucleotide binding]; other site 1037911006150 Cupin domain; Region: Cupin_2; pfam07883 1037911006151 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1037911006152 putative transporter; Provisional; Region: PRK10054 1037911006153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006154 putative substrate translocation pore; other site 1037911006155 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1037911006156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1037911006157 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1037911006158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911006159 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1037911006160 putative active site [active] 1037911006161 heme pocket [chemical binding]; other site 1037911006162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911006163 putative active site [active] 1037911006164 heme pocket [chemical binding]; other site 1037911006165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911006166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911006167 DNA binding residues [nucleotide binding] 1037911006168 dimerization interface [polypeptide binding]; other site 1037911006169 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1037911006170 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1037911006171 catalytic residue [active] 1037911006172 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1037911006173 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1037911006174 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1037911006175 Cytochrome P450; Region: p450; cl12078 1037911006176 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1037911006177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1037911006178 Transposase; Region: HTH_Tnp_1; pfam01527 1037911006179 HTH-like domain; Region: HTH_21; pfam13276 1037911006180 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1037911006181 Integrase core domain; Region: rve; pfam00665 1037911006182 Integrase core domain; Region: rve_3; pfam13683 1037911006183 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1037911006184 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1037911006185 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1037911006186 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1037911006187 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1037911006188 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1037911006189 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1037911006190 MgtC family; Region: MgtC; pfam02308 1037911006191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911006192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911006193 active site 1037911006194 phosphorylation site [posttranslational modification] 1037911006195 intermolecular recognition site; other site 1037911006196 dimerization interface [polypeptide binding]; other site 1037911006197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911006198 DNA binding residues [nucleotide binding] 1037911006199 dimerization interface [polypeptide binding]; other site 1037911006200 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1037911006201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911006202 substrate binding pocket [chemical binding]; other site 1037911006203 membrane-bound complex binding site; other site 1037911006204 hinge residues; other site 1037911006205 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911006206 substrate binding pocket [chemical binding]; other site 1037911006207 membrane-bound complex binding site; other site 1037911006208 hinge residues; other site 1037911006209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911006210 putative active site [active] 1037911006211 heme pocket [chemical binding]; other site 1037911006212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911006213 dimer interface [polypeptide binding]; other site 1037911006214 phosphorylation site [posttranslational modification] 1037911006215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911006216 ATP binding site [chemical binding]; other site 1037911006217 Mg2+ binding site [ion binding]; other site 1037911006218 G-X-G motif; other site 1037911006219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911006220 active site 1037911006221 phosphorylation site [posttranslational modification] 1037911006222 intermolecular recognition site; other site 1037911006223 dimerization interface [polypeptide binding]; other site 1037911006224 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911006225 putative binding surface; other site 1037911006226 active site 1037911006227 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1037911006228 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1037911006229 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1037911006230 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1037911006231 active site 1037911006232 catalytic triad [active] 1037911006233 dimer interface [polypeptide binding]; other site 1037911006234 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1037911006235 Coenzyme A binding pocket [chemical binding]; other site 1037911006236 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1037911006237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911006238 non-specific DNA binding site [nucleotide binding]; other site 1037911006239 salt bridge; other site 1037911006240 sequence-specific DNA binding site [nucleotide binding]; other site 1037911006241 response regulator; Provisional; Region: PRK09483 1037911006242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911006243 active site 1037911006244 phosphorylation site [posttranslational modification] 1037911006245 intermolecular recognition site; other site 1037911006246 dimerization interface [polypeptide binding]; other site 1037911006247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911006248 DNA binding residues [nucleotide binding] 1037911006249 dimerization interface [polypeptide binding]; other site 1037911006250 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1037911006251 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1037911006252 GIY-YIG motif/motif A; other site 1037911006253 active site 1037911006254 catalytic site [active] 1037911006255 putative DNA binding site [nucleotide binding]; other site 1037911006256 metal binding site [ion binding]; metal-binding site 1037911006257 UvrB/uvrC motif; Region: UVR; pfam02151 1037911006258 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1037911006259 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1037911006260 Cupin; Region: Cupin_6; pfam12852 1037911006261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911006262 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911006263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911006264 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1037911006265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006266 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1037911006267 nucleophilic elbow; other site 1037911006268 catalytic triad; other site 1037911006269 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1037911006270 active site 1037911006271 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911006272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006273 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1037911006274 putative dimerization interface [polypeptide binding]; other site 1037911006275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1037911006276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911006277 putative metal binding site [ion binding]; other site 1037911006278 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1037911006279 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1037911006280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911006281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911006282 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911006283 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1037911006284 FMN binding site [chemical binding]; other site 1037911006285 active site 1037911006286 substrate binding site [chemical binding]; other site 1037911006287 catalytic residue [active] 1037911006288 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1037911006289 classical (c) SDRs; Region: SDR_c; cd05233 1037911006290 NAD(P) binding site [chemical binding]; other site 1037911006291 active site 1037911006292 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1037911006293 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1037911006294 CheB methylesterase; Region: CheB_methylest; pfam01339 1037911006295 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1037911006296 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1037911006297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911006298 S-adenosylmethionine binding site [chemical binding]; other site 1037911006299 PAS domain; Region: PAS_9; pfam13426 1037911006300 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 1037911006301 PAS domain; Region: PAS_10; pfam13596 1037911006302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911006303 putative active site [active] 1037911006304 heme pocket [chemical binding]; other site 1037911006305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911006306 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1037911006307 putative active site [active] 1037911006308 heme pocket [chemical binding]; other site 1037911006309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911006310 dimer interface [polypeptide binding]; other site 1037911006311 phosphorylation site [posttranslational modification] 1037911006312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911006313 ATP binding site [chemical binding]; other site 1037911006314 Mg2+ binding site [ion binding]; other site 1037911006315 G-X-G motif; other site 1037911006316 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911006317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911006318 active site 1037911006319 phosphorylation site [posttranslational modification] 1037911006320 intermolecular recognition site; other site 1037911006321 dimerization interface [polypeptide binding]; other site 1037911006322 short chain dehydrogenase; Provisional; Region: PRK06701 1037911006323 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1037911006324 NAD binding site [chemical binding]; other site 1037911006325 metal binding site [ion binding]; metal-binding site 1037911006326 active site 1037911006327 pyrrolysine biosynthesis protein PylC; Region: pyrrolys_PylC; TIGR03909 1037911006328 short chain dehydrogenase; Provisional; Region: PRK06139 1037911006329 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1037911006330 putative NAD(P) binding site [chemical binding]; other site 1037911006331 active site 1037911006332 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1037911006333 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1037911006334 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1037911006335 metal binding site [ion binding]; metal-binding site 1037911006336 Low affinity iron permease; Region: Iron_permease; pfam04120 1037911006337 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1037911006338 General stress protein [General function prediction only]; Region: GsiB; COG3729 1037911006339 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1037911006340 dimanganese center [ion binding]; other site 1037911006341 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1037911006342 dinuclear metal binding motif [ion binding]; other site 1037911006343 histidine kinase; Provisional; Region: PRK13557 1037911006344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911006345 putative active site [active] 1037911006346 heme pocket [chemical binding]; other site 1037911006347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911006348 dimer interface [polypeptide binding]; other site 1037911006349 phosphorylation site [posttranslational modification] 1037911006350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911006351 ATP binding site [chemical binding]; other site 1037911006352 Mg2+ binding site [ion binding]; other site 1037911006353 G-X-G motif; other site 1037911006354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911006355 active site 1037911006356 phosphorylation site [posttranslational modification] 1037911006357 intermolecular recognition site; other site 1037911006358 dimerization interface [polypeptide binding]; other site 1037911006359 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1037911006360 UbiA prenyltransferase family; Region: UbiA; pfam01040 1037911006361 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1037911006362 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1037911006363 Subunit I/III interface [polypeptide binding]; other site 1037911006364 Subunit III/IV interface [polypeptide binding]; other site 1037911006365 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1037911006366 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1037911006367 D-pathway; other site 1037911006368 Putative ubiquinol binding site [chemical binding]; other site 1037911006369 Low-spin heme (heme b) binding site [chemical binding]; other site 1037911006370 Putative water exit pathway; other site 1037911006371 Binuclear center (heme o3/CuB) [ion binding]; other site 1037911006372 K-pathway; other site 1037911006373 Putative proton exit pathway; other site 1037911006374 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1037911006375 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1037911006376 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1037911006377 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1037911006378 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1037911006379 active site 1037911006380 General stress protein [General function prediction only]; Region: GsiB; COG3729 1037911006381 General stress protein [General function prediction only]; Region: GsiB; COG3729 1037911006382 Cache domain; Region: Cache_1; pfam02743 1037911006383 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911006384 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911006385 metal binding site [ion binding]; metal-binding site 1037911006386 active site 1037911006387 I-site; other site 1037911006388 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1037911006389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911006390 Coenzyme A binding pocket [chemical binding]; other site 1037911006391 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1037911006392 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1037911006393 active site 1037911006394 substrate binding site [chemical binding]; other site 1037911006395 Mg2+ binding site [ion binding]; other site 1037911006396 Predicted membrane protein [Function unknown]; Region: COG2323 1037911006397 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 1037911006398 Cytochrome c; Region: Cytochrom_C; cl11414 1037911006399 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911006400 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911006401 Cytochrome c; Region: Cytochrom_C; pfam00034 1037911006402 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1037911006403 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1037911006404 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1037911006405 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1037911006406 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1037911006407 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1037911006408 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911006409 catalytic loop [active] 1037911006410 iron binding site [ion binding]; other site 1037911006411 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1037911006412 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1037911006413 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1037911006414 Walker A/P-loop; other site 1037911006415 ATP binding site [chemical binding]; other site 1037911006416 Q-loop/lid; other site 1037911006417 ABC transporter signature motif; other site 1037911006418 Walker B; other site 1037911006419 D-loop; other site 1037911006420 H-loop/switch region; other site 1037911006421 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1037911006422 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1037911006423 ABC-ATPase subunit interface; other site 1037911006424 dimer interface [polypeptide binding]; other site 1037911006425 putative PBP binding regions; other site 1037911006426 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1037911006427 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1037911006428 putative ligand binding residues [chemical binding]; other site 1037911006429 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911006430 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1037911006431 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911006432 N-terminal plug; other site 1037911006433 ligand-binding site [chemical binding]; other site 1037911006434 fec operon regulator FecR; Reviewed; Region: PRK09774 1037911006435 FecR protein; Region: FecR; pfam04773 1037911006436 RNA polymerase sigma factor; Provisional; Region: PRK12528 1037911006437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911006438 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911006439 DNA binding residues [nucleotide binding] 1037911006440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911006442 putative substrate translocation pore; other site 1037911006443 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1037911006444 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911006445 N-terminal plug; other site 1037911006446 ligand-binding site [chemical binding]; other site 1037911006447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911006448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006449 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911006450 putative effector binding pocket; other site 1037911006451 dimerization interface [polypeptide binding]; other site 1037911006452 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1037911006453 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1037911006454 tetrameric interface [polypeptide binding]; other site 1037911006455 NAD binding site [chemical binding]; other site 1037911006456 catalytic residues [active] 1037911006457 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1037911006458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911006459 substrate binding pocket [chemical binding]; other site 1037911006460 membrane-bound complex binding site; other site 1037911006461 hinge residues; other site 1037911006462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1037911006463 YheO-like PAS domain; Region: PAS_6; pfam08348 1037911006464 HTH domain; Region: HTH_22; pfam13309 1037911006465 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911006466 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1037911006467 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1037911006468 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1037911006469 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 1037911006470 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1037911006471 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911006472 TM-ABC transporter signature motif; other site 1037911006473 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1037911006474 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1037911006475 Walker A/P-loop; other site 1037911006476 ATP binding site [chemical binding]; other site 1037911006477 Q-loop/lid; other site 1037911006478 ABC transporter signature motif; other site 1037911006479 Walker B; other site 1037911006480 D-loop; other site 1037911006481 H-loop/switch region; other site 1037911006482 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1037911006483 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1037911006484 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 1037911006485 putative ligand binding site [chemical binding]; other site 1037911006486 xylose isomerase; Provisional; Region: PRK05474 1037911006487 xylose isomerase; Region: xylose_isom_A; TIGR02630 1037911006488 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1037911006489 putative dimerization interface [polypeptide binding]; other site 1037911006490 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1037911006491 putative ligand binding site [chemical binding]; other site 1037911006492 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911006493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911006494 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1037911006495 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1037911006496 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1037911006497 Trp docking motif [polypeptide binding]; other site 1037911006498 putative active site [active] 1037911006499 Cache domain; Region: Cache_1; pfam02743 1037911006500 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911006501 dimerization interface [polypeptide binding]; other site 1037911006502 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911006503 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911006504 dimer interface [polypeptide binding]; other site 1037911006505 putative CheW interface [polypeptide binding]; other site 1037911006506 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1037911006507 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911006508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911006509 metal binding site [ion binding]; metal-binding site 1037911006510 active site 1037911006511 I-site; other site 1037911006512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911006513 dimerization interface [polypeptide binding]; other site 1037911006514 putative DNA binding site [nucleotide binding]; other site 1037911006515 putative Zn2+ binding site [ion binding]; other site 1037911006516 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911006517 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1037911006518 active site 1037911006519 FMN binding site [chemical binding]; other site 1037911006520 substrate binding site [chemical binding]; other site 1037911006521 homotetramer interface [polypeptide binding]; other site 1037911006522 catalytic residue [active] 1037911006523 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911006524 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911006525 N-terminal plug; other site 1037911006526 ligand-binding site [chemical binding]; other site 1037911006527 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911006528 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911006529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911006530 DNA-binding site [nucleotide binding]; DNA binding site 1037911006531 FCD domain; Region: FCD; pfam07729 1037911006532 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1037911006533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006534 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1037911006535 putative substrate translocation pore; other site 1037911006536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1037911006537 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1037911006538 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1037911006539 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1037911006540 dimer interface [polypeptide binding]; other site 1037911006541 NADP binding site [chemical binding]; other site 1037911006542 catalytic residues [active] 1037911006543 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1037911006544 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1037911006545 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1037911006546 ligand binding site [chemical binding]; other site 1037911006547 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1037911006548 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1037911006549 Walker A/P-loop; other site 1037911006550 ATP binding site [chemical binding]; other site 1037911006551 Q-loop/lid; other site 1037911006552 ABC transporter signature motif; other site 1037911006553 Walker B; other site 1037911006554 D-loop; other site 1037911006555 H-loop/switch region; other site 1037911006556 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1037911006557 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1037911006558 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911006559 TM-ABC transporter signature motif; other site 1037911006560 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1037911006561 active site 1037911006562 catalytic residues [active] 1037911006563 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1037911006564 classical (c) SDRs; Region: SDR_c; cd05233 1037911006565 NAD(P) binding site [chemical binding]; other site 1037911006566 active site 1037911006567 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911006568 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1037911006569 C-terminal domain interface [polypeptide binding]; other site 1037911006570 GSH binding site (G-site) [chemical binding]; other site 1037911006571 dimer interface [polypeptide binding]; other site 1037911006572 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1037911006573 dimer interface [polypeptide binding]; other site 1037911006574 N-terminal domain interface [polypeptide binding]; other site 1037911006575 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911006576 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1037911006577 active site 1037911006578 SUMO-1 interface [polypeptide binding]; other site 1037911006579 putative S-transferase; Provisional; Region: PRK11752 1037911006580 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1037911006581 C-terminal domain interface [polypeptide binding]; other site 1037911006582 GSH binding site (G-site) [chemical binding]; other site 1037911006583 dimer interface [polypeptide binding]; other site 1037911006584 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1037911006585 dimer interface [polypeptide binding]; other site 1037911006586 N-terminal domain interface [polypeptide binding]; other site 1037911006587 active site 1037911006588 HTH-like domain; Region: HTH_21; pfam13276 1037911006589 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1037911006590 Integrase core domain; Region: rve; pfam00665 1037911006591 Integrase core domain; Region: rve_3; pfam13683 1037911006592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1037911006593 Transposase; Region: HTH_Tnp_1; pfam01527 1037911006594 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1037911006595 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1037911006596 putative ligand binding site [chemical binding]; other site 1037911006597 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1037911006598 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1037911006599 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1037911006600 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1037911006601 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1037911006602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911006603 Walker A motif; other site 1037911006604 ATP binding site [chemical binding]; other site 1037911006605 Walker B motif; other site 1037911006606 arginine finger; other site 1037911006607 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911006608 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1037911006609 DNA binding site [nucleotide binding] 1037911006610 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1037911006611 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1037911006612 putative ligand binding site [chemical binding]; other site 1037911006613 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1037911006614 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 1037911006615 putative di-iron ligands [ion binding]; other site 1037911006616 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1037911006617 [2Fe-2S] cluster binding site [ion binding]; other site 1037911006618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1037911006619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911006620 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1037911006621 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1037911006622 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1037911006623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911006624 Coenzyme A binding pocket [chemical binding]; other site 1037911006625 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911006626 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911006627 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1037911006628 conserved cys residue [active] 1037911006629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911006630 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1037911006631 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1037911006632 potential catalytic triad [active] 1037911006633 conserved cys residue [active] 1037911006634 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911006635 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1037911006636 FMN binding site [chemical binding]; other site 1037911006637 active site 1037911006638 substrate binding site [chemical binding]; other site 1037911006639 catalytic residue [active] 1037911006640 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1037911006641 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1037911006642 NAD(P) binding site [chemical binding]; other site 1037911006643 Predicted membrane protein [Function unknown]; Region: COG2259 1037911006644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911006645 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911006646 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1037911006647 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1037911006648 PAS domain; Region: PAS_9; pfam13426 1037911006649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911006650 putative active site [active] 1037911006651 heme pocket [chemical binding]; other site 1037911006652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911006653 DNA binding residues [nucleotide binding] 1037911006654 dimerization interface [polypeptide binding]; other site 1037911006655 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 1037911006656 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1037911006657 active site 1037911006658 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1037911006659 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1037911006660 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1037911006661 acyl-activating enzyme (AAE) consensus motif; other site 1037911006662 acyl-activating enzyme (AAE) consensus motif; other site 1037911006663 putative AMP binding site [chemical binding]; other site 1037911006664 putative active site [active] 1037911006665 putative CoA binding site [chemical binding]; other site 1037911006666 metabolite-proton symporter; Region: 2A0106; TIGR00883 1037911006667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006668 putative substrate translocation pore; other site 1037911006669 Phosphoglycerate mutase family; Region: PGAM; smart00855 1037911006670 catalytic core [active] 1037911006671 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1037911006672 active site 1037911006673 SAM binding site [chemical binding]; other site 1037911006674 homodimer interface [polypeptide binding]; other site 1037911006675 putative hydrolase; Provisional; Region: PRK11460 1037911006676 Predicted esterase [General function prediction only]; Region: COG0400 1037911006677 hypothetical protein; Provisional; Region: PRK11615 1037911006678 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1037911006679 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1037911006680 TrkA-N domain; Region: TrkA_N; pfam02254 1037911006681 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1037911006682 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1037911006683 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1037911006684 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 1037911006685 Autotransporter beta-domain; Region: Autotransporter; smart00869 1037911006686 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1037911006687 DNA binding residues [nucleotide binding] 1037911006688 dimerization interface [polypeptide binding]; other site 1037911006689 methionine gamma-lyase; Provisional; Region: PRK07503 1037911006690 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1037911006691 homodimer interface [polypeptide binding]; other site 1037911006692 substrate-cofactor binding pocket; other site 1037911006693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911006694 catalytic residue [active] 1037911006695 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1037911006696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911006697 putative DNA binding site [nucleotide binding]; other site 1037911006698 putative Zn2+ binding site [ion binding]; other site 1037911006699 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911006700 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911006701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911006702 DNA-binding site [nucleotide binding]; DNA binding site 1037911006703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911006704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911006705 homodimer interface [polypeptide binding]; other site 1037911006706 catalytic residue [active] 1037911006707 Rubredoxin [Energy production and conversion]; Region: COG1773 1037911006708 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1037911006709 iron binding site [ion binding]; other site 1037911006710 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1037911006711 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1037911006712 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1037911006713 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1037911006714 MASE2 domain; Region: MASE2; pfam05230 1037911006715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911006716 metal binding site [ion binding]; metal-binding site 1037911006717 active site 1037911006718 I-site; other site 1037911006719 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1037911006720 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1037911006721 metal binding site [ion binding]; metal-binding site 1037911006722 dimer interface [polypeptide binding]; other site 1037911006723 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1037911006724 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006725 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006726 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006727 RHS Repeat; Region: RHS_repeat; pfam05593 1037911006728 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1037911006729 RHS protein; Region: RHS; pfam03527 1037911006730 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1037911006731 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1037911006732 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911006733 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911006734 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911006735 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1037911006736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006737 putative substrate translocation pore; other site 1037911006738 Pirin-related protein [General function prediction only]; Region: COG1741 1037911006739 Pirin; Region: Pirin; pfam02678 1037911006740 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1037911006741 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1037911006742 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1037911006743 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1037911006744 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1037911006745 ligand binding site [chemical binding]; other site 1037911006746 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1037911006747 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1037911006748 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911006749 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911006750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911006751 putative substrate translocation pore; other site 1037911006752 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1037911006753 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911006754 N-terminal plug; other site 1037911006755 ligand-binding site [chemical binding]; other site 1037911006756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911006757 acetoin reductases; Region: 23BDH; TIGR02415 1037911006758 NAD(P) binding site [chemical binding]; other site 1037911006759 active site 1037911006760 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1037911006761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911006762 Walker A motif; other site 1037911006763 ATP binding site [chemical binding]; other site 1037911006764 Walker B motif; other site 1037911006765 arginine finger; other site 1037911006766 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911006767 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1037911006768 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1037911006769 tetramer interface [polypeptide binding]; other site 1037911006770 TPP-binding site [chemical binding]; other site 1037911006771 heterodimer interface [polypeptide binding]; other site 1037911006772 phosphorylation loop region [posttranslational modification] 1037911006773 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1037911006774 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1037911006775 alpha subunit interface [polypeptide binding]; other site 1037911006776 TPP binding site [chemical binding]; other site 1037911006777 heterodimer interface [polypeptide binding]; other site 1037911006778 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1037911006779 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1037911006780 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1037911006781 E3 interaction surface; other site 1037911006782 lipoyl attachment site [posttranslational modification]; other site 1037911006783 Helix-turn-helix domain; Region: HTH_18; pfam12833 1037911006784 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1037911006785 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1037911006786 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1037911006787 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911006788 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1037911006789 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911006790 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1037911006791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006792 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1037911006793 dimerization interface [polypeptide binding]; other site 1037911006794 substrate binding pocket [chemical binding]; other site 1037911006795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1037911006796 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1037911006797 active site 1037911006798 catalytic tetrad [active] 1037911006799 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1037911006800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911006801 NAD(P) binding site [chemical binding]; other site 1037911006802 active site 1037911006803 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1037911006804 putative hydrophobic ligand binding site [chemical binding]; other site 1037911006805 protein interface [polypeptide binding]; other site 1037911006806 gate; other site 1037911006807 AAA domain; Region: AAA_33; pfam13671 1037911006808 AAA domain; Region: AAA_17; pfam13207 1037911006809 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1037911006810 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1037911006811 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1037911006812 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1037911006813 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1037911006814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911006815 putative active site [active] 1037911006816 heme pocket [chemical binding]; other site 1037911006817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911006818 dimer interface [polypeptide binding]; other site 1037911006819 phosphorylation site [posttranslational modification] 1037911006820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911006821 ATP binding site [chemical binding]; other site 1037911006822 Mg2+ binding site [ion binding]; other site 1037911006823 G-X-G motif; other site 1037911006824 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911006825 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1037911006826 catalytic site [active] 1037911006827 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1037911006828 Repair protein; Region: Repair_PSII; pfam04536 1037911006829 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911006830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911006831 Coenzyme A binding pocket [chemical binding]; other site 1037911006832 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1037911006833 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1037911006834 Na binding site [ion binding]; other site 1037911006835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911006836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006837 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1037911006838 putative substrate binding pocket [chemical binding]; other site 1037911006839 dimerization interface [polypeptide binding]; other site 1037911006840 acetylornithine deacetylase; Provisional; Region: PRK07522 1037911006841 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1037911006842 metal binding site [ion binding]; metal-binding site 1037911006843 putative dimer interface [polypeptide binding]; other site 1037911006844 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1037911006845 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1037911006846 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1037911006847 homotrimer interaction site [polypeptide binding]; other site 1037911006848 putative active site [active] 1037911006849 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1037911006850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1037911006851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1037911006852 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1037911006853 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1037911006854 active site 1037911006855 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911006856 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1037911006857 catalytic triad [active] 1037911006858 dimer interface [polypeptide binding]; other site 1037911006859 conserved cis-peptide bond; other site 1037911006860 LysR family transcriptional regulator; Provisional; Region: PRK14997 1037911006861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006862 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911006863 putative effector binding pocket; other site 1037911006864 dimerization interface [polypeptide binding]; other site 1037911006865 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1037911006866 Helix-turn-helix domain; Region: HTH_18; pfam12833 1037911006867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911006868 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911006869 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911006870 metal binding site [ion binding]; metal-binding site 1037911006871 active site 1037911006872 I-site; other site 1037911006873 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911006874 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1037911006875 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1037911006876 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911006877 Phytase; Region: Phytase; cl17685 1037911006878 Phytase; Region: Phytase; cl17685 1037911006879 TolQ protein; Region: tolQ; TIGR02796 1037911006880 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1037911006881 TolR protein; Region: tolR; TIGR02801 1037911006882 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1037911006883 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1037911006884 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1037911006885 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1037911006886 active site 1037911006887 non-prolyl cis peptide bond; other site 1037911006888 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1037911006889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911006890 membrane-bound complex binding site; other site 1037911006891 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 1037911006892 active site residue [active] 1037911006893 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1037911006894 active site residue [active] 1037911006895 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1037911006896 active site residue [active] 1037911006897 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1037911006898 active site residue [active] 1037911006899 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1037911006900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911006901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911006902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911006903 dimerization interface [polypeptide binding]; other site 1037911006904 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1037911006905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911006906 putative DNA binding site [nucleotide binding]; other site 1037911006907 putative Zn2+ binding site [ion binding]; other site 1037911006908 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1037911006909 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1037911006910 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1037911006911 phosphate binding site [ion binding]; other site 1037911006912 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911006913 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1037911006914 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1037911006915 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1037911006916 dimer interface [polypeptide binding]; other site 1037911006917 ADP-ribose binding site [chemical binding]; other site 1037911006918 active site 1037911006919 nudix motif; other site 1037911006920 metal binding site [ion binding]; metal-binding site 1037911006921 LexA repressor; Provisional; Region: PRK12423 1037911006922 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1037911006923 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1037911006924 Catalytic site [active] 1037911006925 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1037911006926 DNA Polymerase Y-family; Region: PolY_like; cd03468 1037911006927 active site 1037911006928 DNA binding site [nucleotide binding] 1037911006929 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1037911006930 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1037911006931 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1037911006932 putative active site [active] 1037911006933 putative PHP Thumb interface [polypeptide binding]; other site 1037911006934 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1037911006935 generic binding surface I; other site 1037911006936 generic binding surface II; other site 1037911006937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911006938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911006939 dimer interface [polypeptide binding]; other site 1037911006940 phosphorylation site [posttranslational modification] 1037911006941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911006942 ATP binding site [chemical binding]; other site 1037911006943 G-X-G motif; other site 1037911006944 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911006945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911006946 active site 1037911006947 phosphorylation site [posttranslational modification] 1037911006948 intermolecular recognition site; other site 1037911006949 dimerization interface [polypeptide binding]; other site 1037911006950 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1037911006951 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1037911006952 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1037911006953 AAA domain; Region: AAA_21; pfam13304 1037911006954 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1037911006955 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1037911006956 TPP-binding site [chemical binding]; other site 1037911006957 dimer interface [polypeptide binding]; other site 1037911006958 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1037911006959 PYR/PP interface [polypeptide binding]; other site 1037911006960 dimer interface [polypeptide binding]; other site 1037911006961 TPP binding site [chemical binding]; other site 1037911006962 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1037911006963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1037911006964 Transposase; Region: HTH_Tnp_1; pfam01527 1037911006965 HTH-like domain; Region: HTH_21; pfam13276 1037911006966 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1037911006967 Integrase core domain; Region: rve; pfam00665 1037911006968 Integrase core domain; Region: rve_3; pfam13683 1037911006969 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911006970 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1037911006971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1037911006972 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1037911006973 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1037911006974 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1037911006975 catalytic core [active] 1037911006976 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1037911006977 putative inner membrane peptidase; Provisional; Region: PRK11778 1037911006978 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1037911006979 tandem repeat interface [polypeptide binding]; other site 1037911006980 oligomer interface [polypeptide binding]; other site 1037911006981 active site residues [active] 1037911006982 DAK2 domain; Region: Dak2; pfam02734 1037911006983 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1037911006984 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1037911006985 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1037911006986 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 1037911006987 putative NAD(P) binding site [chemical binding]; other site 1037911006988 catalytic Zn binding site [ion binding]; other site 1037911006989 structural Zn binding site [ion binding]; other site 1037911006990 short chain dehydrogenase; Provisional; Region: PRK06841 1037911006991 classical (c) SDRs; Region: SDR_c; cd05233 1037911006992 NAD(P) binding site [chemical binding]; other site 1037911006993 active site 1037911006994 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1037911006995 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1037911006996 putative ligand binding site [chemical binding]; other site 1037911006997 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911006998 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1037911006999 TM-ABC transporter signature motif; other site 1037911007000 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1037911007001 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1037911007002 Walker A/P-loop; other site 1037911007003 ATP binding site [chemical binding]; other site 1037911007004 Q-loop/lid; other site 1037911007005 ABC transporter signature motif; other site 1037911007006 Walker B; other site 1037911007007 D-loop; other site 1037911007008 H-loop/switch region; other site 1037911007009 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1037911007010 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1037911007011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911007012 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1037911007013 DNA binding residues [nucleotide binding] 1037911007014 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1037911007015 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1037911007016 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1037911007017 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1037911007018 Transporter associated domain; Region: CorC_HlyC; smart01091 1037911007019 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911007020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911007021 substrate binding pocket [chemical binding]; other site 1037911007022 membrane-bound complex binding site; other site 1037911007023 hinge residues; other site 1037911007024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911007025 dimer interface [polypeptide binding]; other site 1037911007026 conserved gate region; other site 1037911007027 putative PBP binding loops; other site 1037911007028 ABC-ATPase subunit interface; other site 1037911007029 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911007030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911007031 dimer interface [polypeptide binding]; other site 1037911007032 conserved gate region; other site 1037911007033 putative PBP binding loops; other site 1037911007034 ABC-ATPase subunit interface; other site 1037911007035 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1037911007036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911007037 Walker A/P-loop; other site 1037911007038 ATP binding site [chemical binding]; other site 1037911007039 Q-loop/lid; other site 1037911007040 ABC transporter signature motif; other site 1037911007041 Walker B; other site 1037911007042 D-loop; other site 1037911007043 H-loop/switch region; other site 1037911007044 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1037911007045 homotrimer interaction site [polypeptide binding]; other site 1037911007046 putative active site [active] 1037911007047 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1037911007048 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1037911007049 Bacterial transcriptional regulator; Region: IclR; pfam01614 1037911007050 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1037911007051 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1037911007052 dimer interface [polypeptide binding]; other site 1037911007053 active site 1037911007054 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1037911007055 substrate binding site [chemical binding]; other site 1037911007056 catalytic residue [active] 1037911007057 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1037911007058 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1037911007059 substrate binding site [chemical binding]; other site 1037911007060 ATP binding site [chemical binding]; other site 1037911007061 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1037911007062 PAS fold; Region: PAS_4; pfam08448 1037911007063 PAS fold; Region: PAS_3; pfam08447 1037911007064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911007065 heme pocket [chemical binding]; other site 1037911007066 putative active site [active] 1037911007067 PAS fold; Region: PAS_4; pfam08448 1037911007068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911007069 putative active site [active] 1037911007070 heme pocket [chemical binding]; other site 1037911007071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911007072 dimer interface [polypeptide binding]; other site 1037911007073 phosphorylation site [posttranslational modification] 1037911007074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911007075 ATP binding site [chemical binding]; other site 1037911007076 Mg2+ binding site [ion binding]; other site 1037911007077 G-X-G motif; other site 1037911007078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911007079 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911007080 active site 1037911007081 phosphorylation site [posttranslational modification] 1037911007082 intermolecular recognition site; other site 1037911007083 dimerization interface [polypeptide binding]; other site 1037911007084 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1037911007085 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1037911007086 acyl-activating enzyme (AAE) consensus motif; other site 1037911007087 putative AMP binding site [chemical binding]; other site 1037911007088 putative active site [active] 1037911007089 putative CoA binding site [chemical binding]; other site 1037911007090 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1037911007091 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1037911007092 NAD binding site [chemical binding]; other site 1037911007093 homotetramer interface [polypeptide binding]; other site 1037911007094 homodimer interface [polypeptide binding]; other site 1037911007095 substrate binding site [chemical binding]; other site 1037911007096 active site 1037911007097 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1037911007098 PAS domain; Region: PAS; smart00091 1037911007099 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1037911007100 putative active site [active] 1037911007101 heme pocket [chemical binding]; other site 1037911007102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911007103 Walker B motif; other site 1037911007104 arginine finger; other site 1037911007105 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911007106 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1037911007107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1037911007108 Walker A/P-loop; other site 1037911007109 ATP binding site [chemical binding]; other site 1037911007110 Q-loop/lid; other site 1037911007111 ABC transporter signature motif; other site 1037911007112 Walker B; other site 1037911007113 D-loop; other site 1037911007114 H-loop/switch region; other site 1037911007115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1037911007116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1037911007117 Walker A/P-loop; other site 1037911007118 ATP binding site [chemical binding]; other site 1037911007119 Q-loop/lid; other site 1037911007120 ABC transporter signature motif; other site 1037911007121 Walker B; other site 1037911007122 D-loop; other site 1037911007123 H-loop/switch region; other site 1037911007124 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1037911007125 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1037911007126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911007127 dimer interface [polypeptide binding]; other site 1037911007128 conserved gate region; other site 1037911007129 putative PBP binding loops; other site 1037911007130 ABC-ATPase subunit interface; other site 1037911007131 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1037911007132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911007133 dimer interface [polypeptide binding]; other site 1037911007134 conserved gate region; other site 1037911007135 putative PBP binding loops; other site 1037911007136 ABC-ATPase subunit interface; other site 1037911007137 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1037911007138 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1037911007139 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1037911007140 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1037911007141 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1037911007142 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1037911007143 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1037911007144 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1037911007145 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1037911007146 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1037911007147 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1037911007148 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1037911007149 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 1037911007150 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1037911007151 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1037911007152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911007153 Walker A motif; other site 1037911007154 ATP binding site [chemical binding]; other site 1037911007155 Walker B motif; other site 1037911007156 arginine finger; other site 1037911007157 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1037911007158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1037911007159 phosphopeptide binding site; other site 1037911007160 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 1037911007161 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1037911007162 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1037911007163 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1037911007164 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1037911007165 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1037911007166 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1037911007167 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1037911007168 active site 1037911007169 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1037911007170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1037911007171 active site 1037911007172 ATP binding site [chemical binding]; other site 1037911007173 substrate binding site [chemical binding]; other site 1037911007174 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1037911007175 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1037911007176 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911007177 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1037911007178 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1037911007179 tetramer interface [polypeptide binding]; other site 1037911007180 active site 1037911007181 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1037911007182 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1037911007183 tetramer interface [polypeptide binding]; other site 1037911007184 active site 1037911007185 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1037911007186 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1037911007187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911007188 S-adenosylmethionine binding site [chemical binding]; other site 1037911007189 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1037911007190 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911007191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911007192 Coenzyme A binding pocket [chemical binding]; other site 1037911007193 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1037911007194 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 1037911007195 nudix motif; other site 1037911007196 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1037911007197 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1037911007198 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1037911007199 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1037911007200 B1 nucleotide binding pocket [chemical binding]; other site 1037911007201 B2 nucleotide binding pocket [chemical binding]; other site 1037911007202 CAS motifs; other site 1037911007203 active site 1037911007204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911007205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911007206 active site 1037911007207 phosphorylation site [posttranslational modification] 1037911007208 intermolecular recognition site; other site 1037911007209 dimerization interface [polypeptide binding]; other site 1037911007210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911007211 DNA binding residues [nucleotide binding] 1037911007212 dimerization interface [polypeptide binding]; other site 1037911007213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911007214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911007215 dimer interface [polypeptide binding]; other site 1037911007216 phosphorylation site [posttranslational modification] 1037911007217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911007218 ATP binding site [chemical binding]; other site 1037911007219 Mg2+ binding site [ion binding]; other site 1037911007220 G-X-G motif; other site 1037911007221 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911007222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911007223 active site 1037911007224 phosphorylation site [posttranslational modification] 1037911007225 intermolecular recognition site; other site 1037911007226 dimerization interface [polypeptide binding]; other site 1037911007227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911007228 Coenzyme A binding pocket [chemical binding]; other site 1037911007229 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911007230 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911007231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911007232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911007233 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1037911007234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1037911007235 Walker A/P-loop; other site 1037911007236 ATP binding site [chemical binding]; other site 1037911007237 Q-loop/lid; other site 1037911007238 ABC transporter signature motif; other site 1037911007239 Walker B; other site 1037911007240 D-loop; other site 1037911007241 H-loop/switch region; other site 1037911007242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1037911007243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1037911007244 Walker A/P-loop; other site 1037911007245 ATP binding site [chemical binding]; other site 1037911007246 Q-loop/lid; other site 1037911007247 ABC transporter signature motif; other site 1037911007248 Walker B; other site 1037911007249 D-loop; other site 1037911007250 H-loop/switch region; other site 1037911007251 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1037911007252 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1037911007253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911007254 dimer interface [polypeptide binding]; other site 1037911007255 conserved gate region; other site 1037911007256 putative PBP binding loops; other site 1037911007257 ABC-ATPase subunit interface; other site 1037911007258 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1037911007259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911007260 dimer interface [polypeptide binding]; other site 1037911007261 conserved gate region; other site 1037911007262 putative PBP binding loops; other site 1037911007263 ABC-ATPase subunit interface; other site 1037911007264 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1037911007265 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1037911007266 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1037911007267 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1037911007268 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1037911007269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1037911007270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1037911007271 catalytic residue [active] 1037911007272 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1037911007273 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1037911007274 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1037911007275 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 1037911007276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1037911007277 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1037911007278 RNA/DNA hybrid binding site [nucleotide binding]; other site 1037911007279 active site 1037911007280 conserverd hypothetical protein; Region: TIGR02448 1037911007281 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1037911007282 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1037911007283 active site 1037911007284 catalytic site [active] 1037911007285 substrate binding site [chemical binding]; other site 1037911007286 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1037911007287 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1037911007288 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1037911007289 homodimer interface [polypeptide binding]; other site 1037911007290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911007291 catalytic residue [active] 1037911007292 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1037911007293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911007294 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1037911007295 Coenzyme A binding pocket [chemical binding]; other site 1037911007296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911007297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911007298 dimerization interface [polypeptide binding]; other site 1037911007299 Predicted flavoprotein [General function prediction only]; Region: COG0431 1037911007300 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1037911007301 pyruvate dehydrogenase; Provisional; Region: PRK09124 1037911007302 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1037911007303 PYR/PP interface [polypeptide binding]; other site 1037911007304 dimer interface [polypeptide binding]; other site 1037911007305 tetramer interface [polypeptide binding]; other site 1037911007306 TPP binding site [chemical binding]; other site 1037911007307 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1037911007308 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1037911007309 TPP-binding site [chemical binding]; other site 1037911007310 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911007311 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1037911007312 putative active site [active] 1037911007313 putative FMN binding site [chemical binding]; other site 1037911007314 putative substrate binding site [chemical binding]; other site 1037911007315 putative catalytic residue [active] 1037911007316 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1037911007317 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1037911007318 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1037911007319 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1037911007320 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 1037911007321 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1037911007322 putative ligand binding site [chemical binding]; other site 1037911007323 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1037911007324 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1037911007325 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1037911007326 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1037911007327 substrate binding pocket [chemical binding]; other site 1037911007328 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1037911007329 B12 binding site [chemical binding]; other site 1037911007330 cobalt ligand [ion binding]; other site 1037911007331 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1037911007332 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1037911007333 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1037911007334 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 1037911007335 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1037911007336 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1037911007337 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1037911007338 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1037911007339 active site 1037911007340 SAM binding site [chemical binding]; other site 1037911007341 homodimer interface [polypeptide binding]; other site 1037911007342 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1037911007343 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1037911007344 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 1037911007345 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1037911007346 active site 1037911007347 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1037911007348 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1037911007349 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1037911007350 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1037911007351 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1037911007352 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1037911007353 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1037911007354 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1037911007355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911007356 Walker A motif; other site 1037911007357 ATP binding site [chemical binding]; other site 1037911007358 Walker B motif; other site 1037911007359 arginine finger; other site 1037911007360 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1037911007361 metal ion-dependent adhesion site (MIDAS); other site 1037911007362 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 1037911007363 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 1037911007364 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1037911007365 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 1037911007366 active site 1037911007367 metal binding site [ion binding]; metal-binding site 1037911007368 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1037911007369 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 1037911007370 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1037911007371 aminopeptidase N; Provisional; Region: pepN; PRK14015 1037911007372 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1037911007373 active site 1037911007374 Zn binding site [ion binding]; other site 1037911007375 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1037911007376 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1037911007377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911007378 short chain dehydrogenase; Provisional; Region: PRK05650 1037911007379 NAD(P) binding site [chemical binding]; other site 1037911007380 active site 1037911007381 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1037911007382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1037911007383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911007384 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1037911007385 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1037911007386 Di-iron ligands [ion binding]; other site 1037911007387 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1037911007388 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 1037911007389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911007390 active site 1037911007391 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1037911007392 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1037911007393 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 1037911007394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911007395 NAD(P) binding site [chemical binding]; other site 1037911007396 active site 1037911007397 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1037911007398 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1037911007399 active site 2 [active] 1037911007400 active site 1 [active] 1037911007401 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1037911007402 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1037911007403 dimer interface [polypeptide binding]; other site 1037911007404 active site 1037911007405 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1037911007406 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1037911007407 acyl-activating enzyme (AAE) consensus motif; other site 1037911007408 putative AMP binding site [chemical binding]; other site 1037911007409 putative active site [active] 1037911007410 putative CoA binding site [chemical binding]; other site 1037911007411 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1037911007412 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1037911007413 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1037911007414 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1037911007415 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1037911007416 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1037911007417 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1037911007418 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911007419 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 1037911007420 putative N-terminal domain interface [polypeptide binding]; other site 1037911007421 putative dimer interface [polypeptide binding]; other site 1037911007422 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911007423 exonuclease subunit SbcC; Provisional; Region: PRK10246 1037911007424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911007425 Walker A/P-loop; other site 1037911007426 ATP binding site [chemical binding]; other site 1037911007427 Q-loop/lid; other site 1037911007428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911007429 ABC transporter signature motif; other site 1037911007430 Walker B; other site 1037911007431 D-loop; other site 1037911007432 H-loop/switch region; other site 1037911007433 exonuclease subunit SbcD; Provisional; Region: PRK10966 1037911007434 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1037911007435 active site 1037911007436 metal binding site [ion binding]; metal-binding site 1037911007437 DNA binding site [nucleotide binding] 1037911007438 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1037911007439 Oxygen tolerance; Region: BatD; pfam13584 1037911007440 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1037911007441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911007442 binding surface 1037911007443 TPR motif; other site 1037911007444 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1037911007445 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1037911007446 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1037911007447 metal ion-dependent adhesion site (MIDAS); other site 1037911007448 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1037911007449 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1037911007450 Protein of unknown function DUF58; Region: DUF58; pfam01882 1037911007451 MoxR-like ATPases [General function prediction only]; Region: COG0714 1037911007452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911007453 Walker A motif; other site 1037911007454 ATP binding site [chemical binding]; other site 1037911007455 Walker B motif; other site 1037911007456 arginine finger; other site 1037911007457 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1037911007458 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911007459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911007460 DNA-binding site [nucleotide binding]; DNA binding site 1037911007461 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1037911007462 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911007463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911007464 DNA-binding site [nucleotide binding]; DNA binding site 1037911007465 FCD domain; Region: FCD; pfam07729 1037911007466 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 1037911007467 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1037911007468 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1037911007469 Cupin domain; Region: Cupin_2; pfam07883 1037911007470 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911007471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911007472 DNA-binding site [nucleotide binding]; DNA binding site 1037911007473 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911007474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911007475 homodimer interface [polypeptide binding]; other site 1037911007476 catalytic residue [active] 1037911007477 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1037911007478 short chain dehydrogenase; Provisional; Region: PRK07035 1037911007479 classical (c) SDRs; Region: SDR_c; cd05233 1037911007480 NAD(P) binding site [chemical binding]; other site 1037911007481 active site 1037911007482 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1037911007483 Phosphotransferase enzyme family; Region: APH; pfam01636 1037911007484 putative active site [active] 1037911007485 putative substrate binding site [chemical binding]; other site 1037911007486 ATP binding site [chemical binding]; other site 1037911007487 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1037911007488 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1037911007489 putative ligand binding site [chemical binding]; other site 1037911007490 NAD binding site [chemical binding]; other site 1037911007491 catalytic site [active] 1037911007492 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1037911007493 serine transporter; Region: stp; TIGR00814 1037911007494 Autoinducer synthetase; Region: Autoind_synth; cl17404 1037911007495 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1037911007496 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1037911007497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911007498 DNA binding residues [nucleotide binding] 1037911007499 dimerization interface [polypeptide binding]; other site 1037911007500 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1037911007501 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1037911007502 homodimer interface [polypeptide binding]; other site 1037911007503 active site 1037911007504 TDP-binding site; other site 1037911007505 acceptor substrate-binding pocket; other site 1037911007506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911007507 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1037911007508 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1037911007509 substrate binding site [chemical binding]; other site 1037911007510 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1037911007511 substrate binding site [chemical binding]; other site 1037911007512 ligand binding site [chemical binding]; other site 1037911007513 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1037911007514 universal stress protein UspE; Provisional; Region: PRK11175 1037911007515 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1037911007516 Ligand Binding Site [chemical binding]; other site 1037911007517 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1037911007518 Ligand Binding Site [chemical binding]; other site 1037911007519 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1037911007520 active site 1037911007521 dinuclear metal binding site [ion binding]; other site 1037911007522 dimerization interface [polypeptide binding]; other site 1037911007523 H+ Antiporter protein; Region: 2A0121; TIGR00900 1037911007524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911007525 putative substrate translocation pore; other site 1037911007526 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1037911007527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911007528 active site 1037911007529 phosphorylation site [posttranslational modification] 1037911007530 intermolecular recognition site; other site 1037911007531 dimerization interface [polypeptide binding]; other site 1037911007532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911007533 DNA binding site [nucleotide binding] 1037911007534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911007535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911007536 dimerization interface [polypeptide binding]; other site 1037911007537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911007538 dimer interface [polypeptide binding]; other site 1037911007539 phosphorylation site [posttranslational modification] 1037911007540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911007541 ATP binding site [chemical binding]; other site 1037911007542 Mg2+ binding site [ion binding]; other site 1037911007543 G-X-G motif; other site 1037911007544 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1037911007545 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1037911007546 Beta-lactamase; Region: Beta-lactamase; pfam00144 1037911007547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911007548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911007549 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1037911007550 putative dimerization interface [polypeptide binding]; other site 1037911007551 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1037911007552 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1037911007553 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1037911007554 active site 2 [active] 1037911007555 active site 1 [active] 1037911007556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911007557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911007558 active site 1037911007559 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1037911007560 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1037911007561 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1037911007562 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1037911007563 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1037911007564 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1037911007565 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1037911007566 DctM-like transporters; Region: DctM; pfam06808 1037911007567 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1037911007568 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1037911007569 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1037911007570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1037911007571 LysR family transcriptional regulator; Provisional; Region: PRK14997 1037911007572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911007573 dimerization interface [polypeptide binding]; other site 1037911007574 azoreductase; Reviewed; Region: PRK00170 1037911007575 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1037911007576 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1037911007577 major facilitator superfamily transporter; Provisional; Region: PRK05122 1037911007578 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1037911007579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911007580 Walker A/P-loop; other site 1037911007581 ATP binding site [chemical binding]; other site 1037911007582 Q-loop/lid; other site 1037911007583 ABC transporter signature motif; other site 1037911007584 Walker B; other site 1037911007585 D-loop; other site 1037911007586 H-loop/switch region; other site 1037911007587 ABC transporter; Region: ABC_tran_2; pfam12848 1037911007588 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911007589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911007590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911007591 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1037911007592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911007593 S-adenosylmethionine binding site [chemical binding]; other site 1037911007594 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 1037911007595 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1037911007596 Chain length determinant protein; Region: Wzz; pfam02706 1037911007597 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1037911007598 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1037911007599 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1037911007600 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1037911007601 active site 1037911007602 DNA binding site [nucleotide binding] 1037911007603 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1037911007604 DNA binding site [nucleotide binding] 1037911007605 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1037911007606 nucleotide binding site [chemical binding]; other site 1037911007607 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1037911007608 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1037911007609 putative DNA binding site [nucleotide binding]; other site 1037911007610 putative homodimer interface [polypeptide binding]; other site 1037911007611 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1037911007612 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1037911007613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1037911007614 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1037911007615 putative transcriptional regulator; Provisional; Region: PRK11640 1037911007616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911007617 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1037911007618 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1037911007619 domain interface [polypeptide binding]; other site 1037911007620 putative active site [active] 1037911007621 catalytic site [active] 1037911007622 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1037911007623 domain interface [polypeptide binding]; other site 1037911007624 putative active site [active] 1037911007625 catalytic site [active] 1037911007626 Imelysin; Region: Peptidase_M75; pfam09375 1037911007627 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1037911007628 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1037911007629 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1037911007630 Imelysin; Region: Peptidase_M75; pfam09375 1037911007631 Iron permease FTR1 family; Region: FTR1; cl00475 1037911007632 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1037911007633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911007634 SurA N-terminal domain; Region: SurA_N; pfam09312 1037911007635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911007636 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1037911007637 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1037911007638 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911007639 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911007640 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911007641 LysR family transcriptional regulator; Provisional; Region: PRK14997 1037911007642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911007643 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1037911007644 putative effector binding pocket; other site 1037911007645 putative dimerization interface [polypeptide binding]; other site 1037911007646 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1037911007647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911007648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911007649 putative substrate translocation pore; other site 1037911007650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911007651 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1037911007652 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911007653 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911007654 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 1037911007655 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1037911007656 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1037911007657 putative di-iron ligands [ion binding]; other site 1037911007658 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1037911007659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911007660 NAD(P) binding site [chemical binding]; other site 1037911007661 active site 1037911007662 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911007663 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911007664 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1037911007665 hydrophobic ligand binding site; other site 1037911007666 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911007667 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1037911007668 inhibitor-cofactor binding pocket; inhibition site 1037911007669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911007670 catalytic residue [active] 1037911007671 Male sterility protein; Region: NAD_binding_4; pfam07993 1037911007672 NAD(P) binding site [chemical binding]; other site 1037911007673 active site 1037911007674 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911007675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911007676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911007677 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1037911007678 putative substrate binding pocket [chemical binding]; other site 1037911007679 putative dimerization interface [polypeptide binding]; other site 1037911007680 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1037911007681 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1037911007682 putative NAD(P) binding site [chemical binding]; other site 1037911007683 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911007684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911007685 DNA-binding site [nucleotide binding]; DNA binding site 1037911007686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911007687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911007688 homodimer interface [polypeptide binding]; other site 1037911007689 catalytic residue [active] 1037911007690 phosphoglucomutase; Validated; Region: PRK07564 1037911007691 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1037911007692 active site 1037911007693 substrate binding site [chemical binding]; other site 1037911007694 metal binding site [ion binding]; metal-binding site 1037911007695 Pirin-related protein [General function prediction only]; Region: COG1741 1037911007696 Pirin; Region: Pirin; pfam02678 1037911007697 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1037911007698 Family description; Region: UvrD_C_2; pfam13538 1037911007699 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1037911007700 SnoaL-like domain; Region: SnoaL_2; pfam12680 1037911007701 Helix-turn-helix domain; Region: HTH_18; pfam12833 1037911007702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911007703 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1037911007704 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911007705 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1037911007706 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1037911007707 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911007708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911007709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911007710 DNA binding residues [nucleotide binding] 1037911007711 dimerization interface [polypeptide binding]; other site 1037911007712 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1037911007713 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1037911007714 homodimer interface [polypeptide binding]; other site 1037911007715 homotetramer interface [polypeptide binding]; other site 1037911007716 active site pocket [active] 1037911007717 cleavage site 1037911007718 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1037911007719 active site 1037911007720 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1037911007721 Protease inhibitor Inh; Region: Inh; pfam02974 1037911007722 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1037911007723 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1037911007724 Walker A/P-loop; other site 1037911007725 ATP binding site [chemical binding]; other site 1037911007726 Q-loop/lid; other site 1037911007727 ABC transporter signature motif; other site 1037911007728 Walker B; other site 1037911007729 D-loop; other site 1037911007730 H-loop/switch region; other site 1037911007731 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1037911007732 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911007733 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911007734 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1037911007735 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1037911007736 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1037911007737 catalytic triad [active] 1037911007738 putative active site [active] 1037911007739 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 1037911007740 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1037911007741 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1037911007742 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1037911007743 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1037911007744 catalytic triad [active] 1037911007745 putative active site [active] 1037911007746 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1037911007747 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1037911007748 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1037911007749 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911007750 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1037911007751 nucleophilic elbow; other site 1037911007752 catalytic triad; other site 1037911007753 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1037911007754 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1037911007755 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1037911007756 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1037911007757 DEAD_2; Region: DEAD_2; pfam06733 1037911007758 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1037911007759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1037911007760 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1037911007761 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1037911007762 HTH-like domain; Region: HTH_21; pfam13276 1037911007763 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1037911007764 Integrase core domain; Region: rve; pfam00665 1037911007765 Integrase core domain; Region: rve_3; pfam13683 1037911007766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1037911007767 Transposase; Region: HTH_Tnp_1; pfam01527 1037911007768 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1037911007769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911007770 non-specific DNA binding site [nucleotide binding]; other site 1037911007771 salt bridge; other site 1037911007772 sequence-specific DNA binding site [nucleotide binding]; other site 1037911007773 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1037911007774 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1037911007775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1037911007776 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911007777 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1037911007778 EamA-like transporter family; Region: EamA; pfam00892 1037911007779 EamA-like transporter family; Region: EamA; pfam00892 1037911007780 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1037911007781 Peptidase family U32; Region: Peptidase_U32; pfam01136 1037911007782 Collagenase; Region: DUF3656; pfam12392 1037911007783 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1037911007784 homotrimer interaction site [polypeptide binding]; other site 1037911007785 putative active site [active] 1037911007786 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1037911007787 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1037911007788 dimer interface [polypeptide binding]; other site 1037911007789 active site 1037911007790 Predicted transcriptional regulators [Transcription]; Region: COG1733 1037911007791 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1037911007792 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1037911007793 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1037911007794 tetramer interface [polypeptide binding]; other site 1037911007795 active site 1037911007796 Mg2+/Mn2+ binding site [ion binding]; other site 1037911007797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911007798 G-X-G motif; other site 1037911007799 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1037911007800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911007801 substrate binding pocket [chemical binding]; other site 1037911007802 membrane-bound complex binding site; other site 1037911007803 hinge residues; other site 1037911007804 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1037911007805 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1037911007806 active site 1037911007807 non-prolyl cis peptide bond; other site 1037911007808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911007809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911007810 DNA binding residues [nucleotide binding] 1037911007811 dimerization interface [polypeptide binding]; other site 1037911007812 putative aminotransferase; Provisional; Region: PRK12403 1037911007813 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911007814 inhibitor-cofactor binding pocket; inhibition site 1037911007815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911007816 catalytic residue [active] 1037911007817 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1037911007818 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1037911007819 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1037911007820 NAD(P) binding site [chemical binding]; other site 1037911007821 catalytic residues [active] 1037911007822 Cupin domain; Region: Cupin_2; pfam07883 1037911007823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911007824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911007825 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911007826 putative effector binding pocket; other site 1037911007827 dimerization interface [polypeptide binding]; other site 1037911007828 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 1037911007829 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 1037911007830 putative active site [active] 1037911007831 putative substrate binding site [chemical binding]; other site 1037911007832 putative cosubstrate binding site; other site 1037911007833 catalytic site [active] 1037911007834 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 1037911007835 enoyl-CoA hydratase; Provisional; Region: PRK07659 1037911007836 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911007837 substrate binding site [chemical binding]; other site 1037911007838 oxyanion hole (OAH) forming residues; other site 1037911007839 trimer interface [polypeptide binding]; other site 1037911007840 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1037911007841 TMP-binding site; other site 1037911007842 CsbD-like; Region: CsbD; cl17424 1037911007843 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1037911007844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911007845 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911007846 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911007847 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1037911007848 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1037911007849 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1037911007850 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1037911007851 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1037911007852 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1037911007853 catalytic residues [active] 1037911007854 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1037911007855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911007856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911007857 active site 1037911007858 phosphorylation site [posttranslational modification] 1037911007859 intermolecular recognition site; other site 1037911007860 dimerization interface [polypeptide binding]; other site 1037911007861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911007862 DNA binding site [nucleotide binding] 1037911007863 HAMP domain; Region: HAMP; pfam00672 1037911007864 dimerization interface [polypeptide binding]; other site 1037911007865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1037911007866 dimer interface [polypeptide binding]; other site 1037911007867 phosphorylation site [posttranslational modification] 1037911007868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911007869 Mg2+ binding site [ion binding]; other site 1037911007870 G-X-G motif; other site 1037911007871 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1037911007872 putative active site [active] 1037911007873 putative metal-binding site [ion binding]; other site 1037911007874 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 1037911007875 AAA domain; Region: AAA_23; pfam13476 1037911007876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911007877 Walker A/P-loop; other site 1037911007878 ATP binding site [chemical binding]; other site 1037911007879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1037911007880 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1037911007881 DNA binding site [nucleotide binding] 1037911007882 active site 1037911007883 Int/Topo IB signature motif; other site 1037911007884 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1037911007885 active site 1037911007886 catalytic residues [active] 1037911007887 DNA binding site [nucleotide binding] 1037911007888 Int/Topo IB signature motif; other site 1037911007889 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1037911007890 dimerization interface [polypeptide binding]; other site 1037911007891 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911007892 dimer interface [polypeptide binding]; other site 1037911007893 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1037911007894 putative CheW interface [polypeptide binding]; other site 1037911007895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911007896 putative substrate translocation pore; other site 1037911007897 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1037911007898 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1037911007899 active site 1037911007900 DNA binding site [nucleotide binding] 1037911007901 Int/Topo IB signature motif; other site 1037911007902 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1037911007903 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1037911007904 Ligand binding site; other site 1037911007905 Putative Catalytic site; other site 1037911007906 DXD motif; other site 1037911007907 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1037911007908 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1037911007909 active site 1037911007910 substrate binding site [chemical binding]; other site 1037911007911 cosubstrate binding site; other site 1037911007912 catalytic site [active] 1037911007913 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1037911007914 active site 1037911007915 hexamer interface [polypeptide binding]; other site 1037911007916 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1037911007917 NAD binding site [chemical binding]; other site 1037911007918 substrate binding site [chemical binding]; other site 1037911007919 active site 1037911007920 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1037911007921 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1037911007922 putative active site [active] 1037911007923 putative catalytic site [active] 1037911007924 putative Zn binding site [ion binding]; other site 1037911007925 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1037911007926 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1037911007927 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1037911007928 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1037911007929 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1037911007930 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1037911007931 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1037911007932 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1037911007933 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1037911007934 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1037911007935 Protein of unknown function (DUF770); Region: DUF770; cl01402 1037911007936 HPP family; Region: HPP; pfam04982 1037911007937 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1037911007938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911007939 substrate binding site [chemical binding]; other site 1037911007940 oxyanion hole (OAH) forming residues; other site 1037911007941 trimer interface [polypeptide binding]; other site 1037911007942 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1037911007943 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911007944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911007945 active site 1037911007946 enoyl-CoA hydratase; Provisional; Region: PRK05862 1037911007947 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911007948 substrate binding site [chemical binding]; other site 1037911007949 oxyanion hole (OAH) forming residues; other site 1037911007950 trimer interface [polypeptide binding]; other site 1037911007951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911007952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911007953 active site 1037911007954 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1037911007955 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1037911007956 dimer interface [polypeptide binding]; other site 1037911007957 active site 1037911007958 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1037911007959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911007960 NAD(P) binding site [chemical binding]; other site 1037911007961 active site 1037911007962 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1037911007963 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1037911007964 acyl-activating enzyme (AAE) consensus motif; other site 1037911007965 AMP binding site [chemical binding]; other site 1037911007966 active site 1037911007967 CoA binding site [chemical binding]; other site 1037911007968 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1037911007969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911007970 binding surface 1037911007971 TPR motif; other site 1037911007972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911007973 TPR motif; other site 1037911007974 binding surface 1037911007975 TPR repeat; Region: TPR_11; pfam13414 1037911007976 circadian clock protein KaiC; Reviewed; Region: PRK09302 1037911007977 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1037911007978 Walker A motif; other site 1037911007979 ATP binding site [chemical binding]; other site 1037911007980 Walker B motif; other site 1037911007981 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1037911007982 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1037911007983 Walker A motif; other site 1037911007984 Walker A motif; other site 1037911007985 ATP binding site [chemical binding]; other site 1037911007986 Walker B motif; other site 1037911007987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911007988 dimer interface [polypeptide binding]; other site 1037911007989 phosphorylation site [posttranslational modification] 1037911007990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911007991 ATP binding site [chemical binding]; other site 1037911007992 Mg2+ binding site [ion binding]; other site 1037911007993 G-X-G motif; other site 1037911007994 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911007995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911007996 active site 1037911007997 phosphorylation site [posttranslational modification] 1037911007998 intermolecular recognition site; other site 1037911007999 dimerization interface [polypeptide binding]; other site 1037911008000 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911008001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911008002 active site 1037911008003 phosphorylation site [posttranslational modification] 1037911008004 intermolecular recognition site; other site 1037911008005 dimerization interface [polypeptide binding]; other site 1037911008006 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911008007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911008008 active site 1037911008009 phosphorylation site [posttranslational modification] 1037911008010 intermolecular recognition site; other site 1037911008011 dimerization interface [polypeptide binding]; other site 1037911008012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911008013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911008014 dimer interface [polypeptide binding]; other site 1037911008015 phosphorylation site [posttranslational modification] 1037911008016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911008017 ATP binding site [chemical binding]; other site 1037911008018 Mg2+ binding site [ion binding]; other site 1037911008019 G-X-G motif; other site 1037911008020 CheB methylesterase; Region: CheB_methylest; pfam01339 1037911008021 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1037911008022 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1037911008023 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1037911008024 CHASE3 domain; Region: CHASE3; pfam05227 1037911008025 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1037911008026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911008027 dimer interface [polypeptide binding]; other site 1037911008028 phosphorylation site [posttranslational modification] 1037911008029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911008030 ATP binding site [chemical binding]; other site 1037911008031 Mg2+ binding site [ion binding]; other site 1037911008032 G-X-G motif; other site 1037911008033 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911008034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911008035 active site 1037911008036 phosphorylation site [posttranslational modification] 1037911008037 intermolecular recognition site; other site 1037911008038 dimerization interface [polypeptide binding]; other site 1037911008039 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911008040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911008041 active site 1037911008042 phosphorylation site [posttranslational modification] 1037911008043 intermolecular recognition site; other site 1037911008044 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911008045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911008046 active site 1037911008047 phosphorylation site [posttranslational modification] 1037911008048 intermolecular recognition site; other site 1037911008049 dimerization interface [polypeptide binding]; other site 1037911008050 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911008051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911008052 active site 1037911008053 phosphorylation site [posttranslational modification] 1037911008054 intermolecular recognition site; other site 1037911008055 dimerization interface [polypeptide binding]; other site 1037911008056 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1037911008057 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1037911008058 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1037911008059 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1037911008060 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1037911008061 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1037911008062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911008063 Coenzyme A binding pocket [chemical binding]; other site 1037911008064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911008065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911008066 DNA binding residues [nucleotide binding] 1037911008067 dimerization interface [polypeptide binding]; other site 1037911008068 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1037911008069 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1037911008070 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1037911008071 active site 1037911008072 Zn binding site [ion binding]; other site 1037911008073 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1037911008074 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1037911008075 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1037911008076 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1037911008077 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1037911008078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008079 putative substrate translocation pore; other site 1037911008080 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1037911008081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911008082 NAD(P) binding site [chemical binding]; other site 1037911008083 active site 1037911008084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911008085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008086 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911008087 putative effector binding pocket; other site 1037911008088 dimerization interface [polypeptide binding]; other site 1037911008089 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1037911008090 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1037911008091 active site 1037911008092 catalytic tetrad [active] 1037911008093 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1037911008094 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1037911008095 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1037911008096 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1037911008097 dimer interface [polypeptide binding]; other site 1037911008098 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1037911008099 active site 1037911008100 Fe binding site [ion binding]; other site 1037911008101 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1037911008102 EamA-like transporter family; Region: EamA; pfam00892 1037911008103 EamA-like transporter family; Region: EamA; pfam00892 1037911008104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008105 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1037911008106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911008107 dimerization interface [polypeptide binding]; other site 1037911008108 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1037911008109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911008110 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1037911008111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911008112 dimer interface [polypeptide binding]; other site 1037911008113 active site 1037911008114 metal binding site [ion binding]; metal-binding site 1037911008115 glutathione binding site [chemical binding]; other site 1037911008116 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1037911008117 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1037911008118 catalytic residue [active] 1037911008119 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1037911008120 catalytic residues [active] 1037911008121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1037911008122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911008123 peroxiredoxin; Region: AhpC; TIGR03137 1037911008124 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1037911008125 dimer interface [polypeptide binding]; other site 1037911008126 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1037911008127 catalytic triad [active] 1037911008128 peroxidatic and resolving cysteines [active] 1037911008129 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1037911008130 DNA binding site [nucleotide binding] 1037911008131 dimer interface [polypeptide binding]; other site 1037911008132 active site 1037911008133 Int/Topo IB signature motif; other site 1037911008134 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1037911008135 glutathione reductase; Validated; Region: PRK06116 1037911008136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1037911008137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911008138 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1037911008139 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1037911008140 active site 1037911008141 tetramer interface; other site 1037911008142 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1037911008143 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1037911008144 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1037911008145 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1037911008146 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1037911008147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008148 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1037911008149 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1037911008150 DNA binding site [nucleotide binding] 1037911008151 active site 1037911008152 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1037911008153 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1037911008154 FMN binding site [chemical binding]; other site 1037911008155 substrate binding site [chemical binding]; other site 1037911008156 putative catalytic residue [active] 1037911008157 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1037911008158 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911008159 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1037911008160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911008161 dimer interface [polypeptide binding]; other site 1037911008162 conserved gate region; other site 1037911008163 putative PBP binding loops; other site 1037911008164 ABC-ATPase subunit interface; other site 1037911008165 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1037911008166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911008167 Walker A/P-loop; other site 1037911008168 ATP binding site [chemical binding]; other site 1037911008169 Q-loop/lid; other site 1037911008170 ABC transporter signature motif; other site 1037911008171 Walker B; other site 1037911008172 D-loop; other site 1037911008173 H-loop/switch region; other site 1037911008174 TOBE domain; Region: TOBE; cl01440 1037911008175 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1037911008176 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1037911008177 active site 1037911008178 DNA binding site [nucleotide binding] 1037911008179 Int/Topo IB signature motif; other site 1037911008180 catalytic residues [active] 1037911008181 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1037911008182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911008183 Walker A/P-loop; other site 1037911008184 ATP binding site [chemical binding]; other site 1037911008185 Q-loop/lid; other site 1037911008186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911008187 ABC transporter signature motif; other site 1037911008188 Walker B; other site 1037911008189 D-loop; other site 1037911008190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911008191 Predicted membrane protein [Function unknown]; Region: COG3619 1037911008192 Predicted membrane protein [Function unknown]; Region: COG4392 1037911008193 AzlC protein; Region: AzlC; cl00570 1037911008194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911008195 dimerization interface [polypeptide binding]; other site 1037911008196 putative DNA binding site [nucleotide binding]; other site 1037911008197 putative Zn2+ binding site [ion binding]; other site 1037911008198 arsenical pump membrane protein; Provisional; Region: PRK15445 1037911008199 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1037911008200 transmembrane helices; other site 1037911008201 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1037911008202 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1037911008203 active site 1037911008204 LysE type translocator; Region: LysE; pfam01810 1037911008205 magnesium-transporting ATPase; Provisional; Region: PRK15122 1037911008206 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1037911008207 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1037911008208 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1037911008209 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1037911008210 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1037911008211 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 1037911008212 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1037911008213 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1037911008214 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1037911008215 putative metal binding site [ion binding]; other site 1037911008216 DinB family; Region: DinB; cl17821 1037911008217 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1037911008218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911008219 N-terminal plug; other site 1037911008220 ligand-binding site [chemical binding]; other site 1037911008221 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1037911008222 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1037911008223 putative ligand binding residues [chemical binding]; other site 1037911008224 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1037911008225 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1037911008226 Walker A/P-loop; other site 1037911008227 ATP binding site [chemical binding]; other site 1037911008228 Q-loop/lid; other site 1037911008229 ABC transporter signature motif; other site 1037911008230 Walker B; other site 1037911008231 D-loop; other site 1037911008232 H-loop/switch region; other site 1037911008233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1037911008234 ABC-ATPase subunit interface; other site 1037911008235 dimer interface [polypeptide binding]; other site 1037911008236 putative PBP binding regions; other site 1037911008237 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1037911008238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1037911008239 ABC-ATPase subunit interface; other site 1037911008240 dimer interface [polypeptide binding]; other site 1037911008241 putative PBP binding regions; other site 1037911008242 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1037911008243 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1037911008244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911008245 Walker A/P-loop; other site 1037911008246 ATP binding site [chemical binding]; other site 1037911008247 Q-loop/lid; other site 1037911008248 ABC transporter signature motif; other site 1037911008249 Walker B; other site 1037911008250 D-loop; other site 1037911008251 H-loop/switch region; other site 1037911008252 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1037911008253 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1037911008254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911008255 Walker A/P-loop; other site 1037911008256 ATP binding site [chemical binding]; other site 1037911008257 Q-loop/lid; other site 1037911008258 ABC transporter signature motif; other site 1037911008259 Walker B; other site 1037911008260 D-loop; other site 1037911008261 H-loop/switch region; other site 1037911008262 RNA polymerase sigma factor; Provisional; Region: PRK12528 1037911008263 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911008264 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1037911008265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911008266 Condensation domain; Region: Condensation; pfam00668 1037911008267 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1037911008268 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1037911008269 Condensation domain; Region: Condensation; pfam00668 1037911008270 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1037911008271 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1037911008272 Condensation domain; Region: Condensation; pfam00668 1037911008273 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1037911008274 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1037911008275 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1037911008276 acyl-activating enzyme (AAE) consensus motif; other site 1037911008277 AMP binding site [chemical binding]; other site 1037911008278 isochorismate synthase EntC; Provisional; Region: PRK15016 1037911008279 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1037911008280 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1037911008281 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1037911008282 acyl-activating enzyme (AAE) consensus motif; other site 1037911008283 active site 1037911008284 AMP binding site [chemical binding]; other site 1037911008285 substrate binding site [chemical binding]; other site 1037911008286 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1037911008287 histidine decarboxylase; Provisional; Region: PRK02769 1037911008288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911008289 catalytic residue [active] 1037911008290 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 1037911008291 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911008292 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1037911008293 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 1037911008294 Yeast cell wall synthesis protein KRE9/KNH1; Region: KRE9; pfam05390 1037911008295 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1037911008296 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911008297 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911008298 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911008299 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911008300 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911008301 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911008302 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1037911008303 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1037911008304 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1037911008305 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1037911008306 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1037911008307 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263 1037911008308 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1037911008309 Walker A/P-loop; other site 1037911008310 ATP binding site [chemical binding]; other site 1037911008311 Q-loop/lid; other site 1037911008312 ABC transporter signature motif; other site 1037911008313 Walker B; other site 1037911008314 D-loop; other site 1037911008315 H-loop/switch region; other site 1037911008316 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1037911008317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911008318 dimer interface [polypeptide binding]; other site 1037911008319 conserved gate region; other site 1037911008320 putative PBP binding loops; other site 1037911008321 ABC-ATPase subunit interface; other site 1037911008322 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1037911008323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911008324 dimer interface [polypeptide binding]; other site 1037911008325 conserved gate region; other site 1037911008326 putative PBP binding loops; other site 1037911008327 ABC-ATPase subunit interface; other site 1037911008328 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1037911008329 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1037911008330 benzoate transport; Region: 2A0115; TIGR00895 1037911008331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008332 putative substrate translocation pore; other site 1037911008333 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1037911008334 putative FMN binding site [chemical binding]; other site 1037911008335 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 1037911008336 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 1037911008337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911008338 putative active site [active] 1037911008339 putative metal binding site [ion binding]; other site 1037911008340 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1037911008341 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1037911008342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911008343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911008344 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1037911008345 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911008346 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1037911008347 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911008348 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911008349 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1037911008350 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1037911008351 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1037911008352 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911008353 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1037911008354 catalytic triad [active] 1037911008355 dimer interface [polypeptide binding]; other site 1037911008356 conserved cis-peptide bond; other site 1037911008357 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911008358 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1037911008359 catalytic triad [active] 1037911008360 dimer interface [polypeptide binding]; other site 1037911008361 conserved cis-peptide bond; other site 1037911008362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911008363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911008365 dimerization interface [polypeptide binding]; other site 1037911008366 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1037911008367 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1037911008368 putative dimer interface [polypeptide binding]; other site 1037911008369 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 1037911008370 PAS fold; Region: PAS_4; pfam08448 1037911008371 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911008372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008373 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1037911008374 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1037911008375 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1037911008376 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1037911008377 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1037911008378 inhibitor site; inhibition site 1037911008379 active site 1037911008380 dimer interface [polypeptide binding]; other site 1037911008381 catalytic residue [active] 1037911008382 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1037911008383 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1037911008384 dimer interface [polypeptide binding]; other site 1037911008385 NADP binding site [chemical binding]; other site 1037911008386 catalytic residues [active] 1037911008387 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911008388 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1037911008389 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911008390 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1037911008391 conserved cys residue [active] 1037911008392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008393 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1037911008394 Predicted transcriptional regulators [Transcription]; Region: COG1733 1037911008395 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1037911008396 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1037911008397 NmrA-like family; Region: NmrA; pfam05368 1037911008398 NAD(P) binding site [chemical binding]; other site 1037911008399 active site lysine 1037911008400 META domain; Region: META; pfam03724 1037911008401 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1037911008402 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1037911008403 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1037911008404 conserved cys residue [active] 1037911008405 Penicillin amidase; Region: Penicil_amidase; pfam01804 1037911008406 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1037911008407 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1037911008408 active site 1037911008409 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1037911008410 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1037911008411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911008412 dimer interface [polypeptide binding]; other site 1037911008413 conserved gate region; other site 1037911008414 putative PBP binding loops; other site 1037911008415 ABC-ATPase subunit interface; other site 1037911008416 NMT1-like family; Region: NMT1_2; pfam13379 1037911008417 NMT1/THI5 like; Region: NMT1; pfam09084 1037911008418 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1037911008419 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1037911008420 Walker A/P-loop; other site 1037911008421 ATP binding site [chemical binding]; other site 1037911008422 Q-loop/lid; other site 1037911008423 ABC transporter signature motif; other site 1037911008424 Walker B; other site 1037911008425 D-loop; other site 1037911008426 H-loop/switch region; other site 1037911008427 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911008428 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911008429 active site 1037911008430 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1037911008431 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1037911008432 Cupin; Region: Cupin_6; pfam12852 1037911008433 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911008434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911008436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008437 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1037911008438 putative effector binding pocket; other site 1037911008439 putative dimerization interface [polypeptide binding]; other site 1037911008440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1037911008441 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1037911008442 active site 1037911008443 catalytic tetrad [active] 1037911008444 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1037911008445 hydrophobic ligand binding site; other site 1037911008446 Protein of unknown function, DUF; Region: DUF411; cl01142 1037911008447 Predicted membrane protein [Function unknown]; Region: COG1238 1037911008448 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911008449 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911008450 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1037911008451 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1037911008452 dimerization interface [polypeptide binding]; other site 1037911008453 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1037911008454 NAD binding site [chemical binding]; other site 1037911008455 ligand binding site [chemical binding]; other site 1037911008456 catalytic site [active] 1037911008457 glycogen synthase; Provisional; Region: glgA; PRK00654 1037911008458 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1037911008459 ADP-binding pocket [chemical binding]; other site 1037911008460 homodimer interface [polypeptide binding]; other site 1037911008461 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1037911008462 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1037911008463 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1037911008464 catalytic site [active] 1037911008465 active site 1037911008466 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1037911008467 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1037911008468 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1037911008469 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1037911008470 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1037911008471 active site 1037911008472 catalytic site [active] 1037911008473 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1037911008474 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1037911008475 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1037911008476 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1037911008477 active site 1037911008478 catalytic site [active] 1037911008479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911008480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911008481 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1037911008482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911008483 S-adenosylmethionine binding site [chemical binding]; other site 1037911008484 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1037911008485 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1037911008486 DXD motif; other site 1037911008487 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1037911008488 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1037911008489 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911008490 N-terminal plug; other site 1037911008491 ligand-binding site [chemical binding]; other site 1037911008492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911008493 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911008494 dimer interface [polypeptide binding]; other site 1037911008495 putative CheW interface [polypeptide binding]; other site 1037911008496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911008497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008498 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1037911008499 putative effector binding pocket; other site 1037911008500 putative dimerization interface [polypeptide binding]; other site 1037911008501 short chain dehydrogenase; Provisional; Region: PRK12744 1037911008502 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1037911008503 NADP binding site [chemical binding]; other site 1037911008504 homodimer interface [polypeptide binding]; other site 1037911008505 active site 1037911008506 substrate binding site [chemical binding]; other site 1037911008507 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911008508 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1037911008509 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1037911008510 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1037911008511 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911008512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911008513 Coenzyme A binding pocket [chemical binding]; other site 1037911008514 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1037911008515 active site 1037911008516 catalytic residues [active] 1037911008517 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1037911008518 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1037911008519 putative metal binding site [ion binding]; other site 1037911008520 putative homodimer interface [polypeptide binding]; other site 1037911008521 putative homotetramer interface [polypeptide binding]; other site 1037911008522 putative homodimer-homodimer interface [polypeptide binding]; other site 1037911008523 putative allosteric switch controlling residues; other site 1037911008524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911008525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911008527 dimerization interface [polypeptide binding]; other site 1037911008528 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1037911008529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008530 putative substrate translocation pore; other site 1037911008531 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1037911008532 dimer interface [polypeptide binding]; other site 1037911008533 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1037911008534 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1037911008535 dimer interface [polypeptide binding]; other site 1037911008536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911008537 catalytic residue [active] 1037911008538 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1037911008539 FOG: CBS domain [General function prediction only]; Region: COG0517 1037911008540 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1037911008541 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1037911008542 homodimer interface [polypeptide binding]; other site 1037911008543 substrate-cofactor binding pocket; other site 1037911008544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911008545 catalytic residue [active] 1037911008546 YcaO domain protein; Region: TIGR03549 1037911008547 OsmC-like protein; Region: OsmC; pfam02566 1037911008548 YcaO-like family; Region: YcaO; pfam02624 1037911008549 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911008550 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1037911008551 catalytic triad [active] 1037911008552 conserved cis-peptide bond; other site 1037911008553 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1037911008554 nudix motif; other site 1037911008555 AAA domain; Region: AAA_33; pfam13671 1037911008556 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1037911008557 active site 1037911008558 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1037911008559 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1037911008560 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1037911008561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911008563 dimerization interface [polypeptide binding]; other site 1037911008564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911008565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911008567 putative substrate translocation pore; other site 1037911008568 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1037911008569 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1037911008570 proline/glycine betaine transporter; Provisional; Region: PRK10642 1037911008571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008572 putative substrate translocation pore; other site 1037911008573 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1037911008574 GAF domain; Region: GAF; pfam01590 1037911008575 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1037911008576 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1037911008577 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911008578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008580 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1037911008581 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1037911008582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008583 putative substrate translocation pore; other site 1037911008584 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911008585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008586 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911008587 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008589 putative substrate translocation pore; other site 1037911008590 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1037911008591 amidase; Validated; Region: PRK06565 1037911008592 Amidase; Region: Amidase; cl11426 1037911008593 Amidase; Region: Amidase; cl11426 1037911008594 SnoaL-like domain; Region: SnoaL_2; pfam12680 1037911008595 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911008596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911008597 DNA-binding site [nucleotide binding]; DNA binding site 1037911008598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911008599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911008600 homodimer interface [polypeptide binding]; other site 1037911008601 catalytic residue [active] 1037911008602 EamA-like transporter family; Region: EamA; pfam00892 1037911008603 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1037911008604 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1037911008605 CoenzymeA binding site [chemical binding]; other site 1037911008606 subunit interaction site [polypeptide binding]; other site 1037911008607 PHB binding site; other site 1037911008608 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1037911008609 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1037911008610 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1037911008611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008612 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 1037911008613 putative dimerization interface [polypeptide binding]; other site 1037911008614 putative substrate binding pocket [chemical binding]; other site 1037911008615 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1037911008616 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1037911008617 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1037911008618 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1037911008619 AAA domain; Region: AAA_28; pfam13521 1037911008620 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1037911008621 active site 1037911008622 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1037911008623 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1037911008624 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1037911008625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911008626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911008627 homodimer interface [polypeptide binding]; other site 1037911008628 catalytic residue [active] 1037911008629 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1037911008630 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1037911008631 dimer interface [polypeptide binding]; other site 1037911008632 putative radical transfer pathway; other site 1037911008633 diiron center [ion binding]; other site 1037911008634 tyrosyl radical; other site 1037911008635 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1037911008636 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1037911008637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911008638 S-adenosylmethionine binding site [chemical binding]; other site 1037911008639 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1037911008640 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1037911008641 hypothetical protein; Provisional; Region: PRK10621 1037911008642 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1037911008643 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1037911008644 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1037911008645 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1037911008646 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1037911008647 putative NADH binding site [chemical binding]; other site 1037911008648 putative active site [active] 1037911008649 nudix motif; other site 1037911008650 putative metal binding site [ion binding]; other site 1037911008651 enoyl-CoA hydratase; Provisional; Region: PRK06142 1037911008652 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911008653 substrate binding site [chemical binding]; other site 1037911008654 oxyanion hole (OAH) forming residues; other site 1037911008655 trimer interface [polypeptide binding]; other site 1037911008656 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1037911008657 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 1037911008658 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1037911008659 hinge; other site 1037911008660 active site 1037911008661 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1037911008662 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1037911008663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911008664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911008665 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1037911008666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911008667 Coenzyme A binding pocket [chemical binding]; other site 1037911008668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911008669 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1037911008670 putative substrate binding pocket [chemical binding]; other site 1037911008671 putative dimerization interface [polypeptide binding]; other site 1037911008672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911008674 putative substrate translocation pore; other site 1037911008675 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911008676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911008677 DNA-binding site [nucleotide binding]; DNA binding site 1037911008678 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1037911008679 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1037911008680 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1037911008681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008682 metabolite-proton symporter; Region: 2A0106; TIGR00883 1037911008683 putative substrate translocation pore; other site 1037911008684 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1037911008685 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1037911008686 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1037911008687 PAS fold; Region: PAS_4; pfam08448 1037911008688 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1037911008689 GAF domain; Region: GAF; pfam01590 1037911008690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911008691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911008692 dimer interface [polypeptide binding]; other site 1037911008693 phosphorylation site [posttranslational modification] 1037911008694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911008695 ATP binding site [chemical binding]; other site 1037911008696 Mg2+ binding site [ion binding]; other site 1037911008697 G-X-G motif; other site 1037911008698 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911008699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911008700 active site 1037911008701 phosphorylation site [posttranslational modification] 1037911008702 intermolecular recognition site; other site 1037911008703 dimerization interface [polypeptide binding]; other site 1037911008704 glycogen branching enzyme; Provisional; Region: PRK05402 1037911008705 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1037911008706 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1037911008707 active site 1037911008708 catalytic site [active] 1037911008709 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1037911008710 trehalose synthase; Region: treS_nterm; TIGR02456 1037911008711 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1037911008712 active site 1037911008713 catalytic site [active] 1037911008714 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1037911008715 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1037911008716 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1037911008717 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1037911008718 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1037911008719 active site 1037911008720 homodimer interface [polypeptide binding]; other site 1037911008721 catalytic site [active] 1037911008722 acceptor binding site [chemical binding]; other site 1037911008723 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1037911008724 MgtC family; Region: MgtC; pfam02308 1037911008725 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 1037911008726 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1037911008727 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1037911008728 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1037911008729 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911008730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911008731 DNA-binding site [nucleotide binding]; DNA binding site 1037911008732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911008733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911008734 homodimer interface [polypeptide binding]; other site 1037911008735 catalytic residue [active] 1037911008736 short chain dehydrogenase; Provisional; Region: PRK06123 1037911008737 classical (c) SDRs; Region: SDR_c; cd05233 1037911008738 NAD(P) binding site [chemical binding]; other site 1037911008739 active site 1037911008740 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1037911008741 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1037911008742 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1037911008743 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911008744 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911008745 metal binding site [ion binding]; metal-binding site 1037911008746 active site 1037911008747 I-site; other site 1037911008748 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911008749 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1037911008750 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1037911008751 Protein export membrane protein; Region: SecD_SecF; cl14618 1037911008752 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1037911008753 Protein export membrane protein; Region: SecD_SecF; cl14618 1037911008754 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1037911008755 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911008756 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911008757 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1037911008758 dimer interface [polypeptide binding]; other site 1037911008759 catalytic triad [active] 1037911008760 peroxidatic and resolving cysteines [active] 1037911008761 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911008762 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1037911008763 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911008764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008766 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1037911008767 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1037911008768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1037911008769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911008770 dimer interface [polypeptide binding]; other site 1037911008771 conserved gate region; other site 1037911008772 putative PBP binding loops; other site 1037911008773 ABC-ATPase subunit interface; other site 1037911008774 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1037911008775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911008776 dimer interface [polypeptide binding]; other site 1037911008777 conserved gate region; other site 1037911008778 putative PBP binding loops; other site 1037911008779 ABC-ATPase subunit interface; other site 1037911008780 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1037911008781 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1037911008782 Walker A/P-loop; other site 1037911008783 ATP binding site [chemical binding]; other site 1037911008784 Q-loop/lid; other site 1037911008785 ABC transporter signature motif; other site 1037911008786 Walker B; other site 1037911008787 D-loop; other site 1037911008788 H-loop/switch region; other site 1037911008789 TOBE domain; Region: TOBE_2; pfam08402 1037911008790 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1037911008791 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1037911008792 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1037911008793 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1037911008794 N- and C-terminal domain interface [polypeptide binding]; other site 1037911008795 D-xylulose kinase; Region: XylB; TIGR01312 1037911008796 active site 1037911008797 MgATP binding site [chemical binding]; other site 1037911008798 catalytic site [active] 1037911008799 metal binding site [ion binding]; metal-binding site 1037911008800 xylulose binding site [chemical binding]; other site 1037911008801 putative homodimer interface [polypeptide binding]; other site 1037911008802 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1037911008803 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1037911008804 putative substrate binding site [chemical binding]; other site 1037911008805 putative ATP binding site [chemical binding]; other site 1037911008806 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1037911008807 Autotransporter beta-domain; Region: Autotransporter; smart00869 1037911008808 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1037911008809 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1037911008810 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1037911008811 active site 1037911008812 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1037911008813 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1037911008814 active site 1037911008815 dimer interface [polypeptide binding]; other site 1037911008816 non-prolyl cis peptide bond; other site 1037911008817 insertion regions; other site 1037911008818 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1037911008819 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 1037911008820 RNA polymerase sigma factor; Provisional; Region: PRK12537 1037911008821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911008822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911008823 DNA binding residues [nucleotide binding] 1037911008824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1037911008825 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1037911008826 sensor protein RstB; Provisional; Region: PRK10604 1037911008827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911008828 dimer interface [polypeptide binding]; other site 1037911008829 phosphorylation site [posttranslational modification] 1037911008830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911008831 ATP binding site [chemical binding]; other site 1037911008832 Mg2+ binding site [ion binding]; other site 1037911008833 G-X-G motif; other site 1037911008834 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911008835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911008836 active site 1037911008837 phosphorylation site [posttranslational modification] 1037911008838 intermolecular recognition site; other site 1037911008839 dimerization interface [polypeptide binding]; other site 1037911008840 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911008841 DNA binding site [nucleotide binding] 1037911008842 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1037911008843 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911008844 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911008845 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1037911008846 Protein export membrane protein; Region: SecD_SecF; cl14618 1037911008847 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1037911008848 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911008849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008850 Helix-turn-helix domain; Region: HTH_18; pfam12833 1037911008851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911008852 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1037911008853 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1037911008854 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1037911008855 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1037911008856 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1037911008857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1037911008858 DNA binding site [nucleotide binding] 1037911008859 domain linker motif; other site 1037911008860 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1037911008861 putative dimerization interface [polypeptide binding]; other site 1037911008862 putative ligand binding site [chemical binding]; other site 1037911008863 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1037911008864 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1037911008865 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1037911008866 substrate binding site [chemical binding]; other site 1037911008867 ATP binding site [chemical binding]; other site 1037911008868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911008869 D-galactonate transporter; Region: 2A0114; TIGR00893 1037911008870 putative substrate translocation pore; other site 1037911008871 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1037911008872 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1037911008873 dimerization interface [polypeptide binding]; other site 1037911008874 ligand binding site [chemical binding]; other site 1037911008875 NADP binding site [chemical binding]; other site 1037911008876 catalytic site [active] 1037911008877 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911008878 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1037911008879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911008880 dimerization interface [polypeptide binding]; other site 1037911008881 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911008882 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911008883 dimer interface [polypeptide binding]; other site 1037911008884 putative CheW interface [polypeptide binding]; other site 1037911008885 xanthine permease; Region: pbuX; TIGR03173 1037911008886 Water Stress and Hypersensitive response; Region: WHy; smart00769 1037911008887 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1037911008888 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1037911008889 putative active site [active] 1037911008890 catalytic triad [active] 1037911008891 putative dimer interface [polypeptide binding]; other site 1037911008892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911008893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911008894 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1037911008895 putative substrate binding pocket [chemical binding]; other site 1037911008896 putative dimerization interface [polypeptide binding]; other site 1037911008897 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1037911008898 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1037911008899 Peptidase M35 family; Region: M35_like; cl03449 1037911008900 active site 1037911008901 Zn binding site [ion binding]; other site 1037911008902 hypothetical protein; Provisional; Region: PRK10593 1037911008903 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1037911008904 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1037911008905 FecR protein; Region: FecR; pfam04773 1037911008906 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1037911008907 putative active site [active] 1037911008908 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911008909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911008910 Walker A motif; other site 1037911008911 ATP binding site [chemical binding]; other site 1037911008912 Walker B motif; other site 1037911008913 arginine finger; other site 1037911008914 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911008915 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1037911008916 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1037911008917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911008918 active site 1037911008919 motif I; other site 1037911008920 motif II; other site 1037911008921 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1037911008922 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1037911008923 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1037911008924 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1037911008925 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1037911008926 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1037911008927 hypothetical protein; Provisional; Region: PRK10649 1037911008928 Sulfatase; Region: Sulfatase; pfam00884 1037911008929 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1037911008930 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911008931 N-terminal plug; other site 1037911008932 ligand-binding site [chemical binding]; other site 1037911008933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911008934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911008935 Coenzyme A binding pocket [chemical binding]; other site 1037911008936 Predicted ATPase [General function prediction only]; Region: COG1485 1037911008937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911008938 Walker A/P-loop; other site 1037911008939 ATP binding site [chemical binding]; other site 1037911008940 Q-loop/lid; other site 1037911008941 ABC transporter signature motif; other site 1037911008942 Walker B; other site 1037911008943 D-loop; other site 1037911008944 H-loop/switch region; other site 1037911008945 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1037911008946 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1037911008947 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911008948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911008949 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911008950 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1037911008951 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1037911008952 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1037911008953 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911008954 N-terminal plug; other site 1037911008955 ligand-binding site [chemical binding]; other site 1037911008956 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1037911008957 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1037911008958 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1037911008959 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1037911008960 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1037911008961 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1037911008962 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911008963 TM-ABC transporter signature motif; other site 1037911008964 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1037911008965 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1037911008966 Walker A/P-loop; other site 1037911008967 ATP binding site [chemical binding]; other site 1037911008968 Q-loop/lid; other site 1037911008969 ABC transporter signature motif; other site 1037911008970 Walker B; other site 1037911008971 D-loop; other site 1037911008972 H-loop/switch region; other site 1037911008973 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1037911008974 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1037911008975 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1037911008976 putative ligand binding site [chemical binding]; other site 1037911008977 putative oxidoreductase; Provisional; Region: PRK11579 1037911008978 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1037911008979 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1037911008980 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1037911008981 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1037911008982 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1037911008983 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1037911008984 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1037911008985 PYR/PP interface [polypeptide binding]; other site 1037911008986 dimer interface [polypeptide binding]; other site 1037911008987 TPP binding site [chemical binding]; other site 1037911008988 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1037911008989 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1037911008990 TPP-binding site; other site 1037911008991 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1037911008992 KduI/IolB family; Region: KduI; pfam04962 1037911008993 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1037911008994 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1037911008995 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1037911008996 substrate binding site [chemical binding]; other site 1037911008997 ATP binding site [chemical binding]; other site 1037911008998 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1037911008999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1037911009000 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1037911009001 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1037911009002 putative active site [active] 1037911009003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911009004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911009005 active site 1037911009006 phosphorylation site [posttranslational modification] 1037911009007 intermolecular recognition site; other site 1037911009008 dimerization interface [polypeptide binding]; other site 1037911009009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911009010 DNA binding site [nucleotide binding] 1037911009011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911009012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911009013 dimerization interface [polypeptide binding]; other site 1037911009014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911009015 dimer interface [polypeptide binding]; other site 1037911009016 phosphorylation site [posttranslational modification] 1037911009017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911009018 ATP binding site [chemical binding]; other site 1037911009019 Mg2+ binding site [ion binding]; other site 1037911009020 G-X-G motif; other site 1037911009021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1037911009022 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1037911009023 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1037911009024 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1037911009025 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 1037911009026 glutathione S-transferase; Provisional; Region: PRK15113 1037911009027 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1037911009028 C-terminal domain interface [polypeptide binding]; other site 1037911009029 GSH binding site (G-site) [chemical binding]; other site 1037911009030 dimer interface [polypeptide binding]; other site 1037911009031 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1037911009032 putative dimer interface [polypeptide binding]; other site 1037911009033 N-terminal domain interface [polypeptide binding]; other site 1037911009034 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911009035 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1037911009036 nucleophilic elbow; other site 1037911009037 catalytic triad; other site 1037911009038 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1037911009039 Predicted membrane protein [Function unknown]; Region: COG3503 1037911009040 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1037911009041 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1037911009042 THF binding site; other site 1037911009043 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1037911009044 substrate binding site [chemical binding]; other site 1037911009045 THF binding site; other site 1037911009046 zinc-binding site [ion binding]; other site 1037911009047 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1037911009048 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1037911009049 dimer interface [polypeptide binding]; other site 1037911009050 active site 1037911009051 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1037911009052 catalytic residues [active] 1037911009053 substrate binding site [chemical binding]; other site 1037911009054 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1037911009055 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1037911009056 NAD(P) binding pocket [chemical binding]; other site 1037911009057 HTH-like domain; Region: HTH_21; pfam13276 1037911009058 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1037911009059 Integrase core domain; Region: rve; pfam00665 1037911009060 Integrase core domain; Region: rve_3; pfam13683 1037911009061 glutaminase; Provisional; Region: PRK00971 1037911009062 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1037911009063 Cupin domain; Region: Cupin_2; pfam07883 1037911009064 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911009065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009066 aldolase II superfamily protein; Provisional; Region: PRK07044 1037911009067 active site 1037911009068 intersubunit interface [polypeptide binding]; other site 1037911009069 Zn2+ binding site [ion binding]; other site 1037911009070 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1037911009071 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1037911009072 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1037911009073 proposed catalytic triad [active] 1037911009074 conserved cys residue [active] 1037911009075 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1037911009076 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 1037911009077 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1037911009078 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1037911009079 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1037911009080 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1037911009081 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1037911009082 AZL_007950 family protein; Region: AZL_007950_fam; cl14861 1037911009083 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1037911009084 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1037911009085 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1037911009086 Cu(I) binding site [ion binding]; other site 1037911009087 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1037911009088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911009089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911009090 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1037911009091 putative substrate binding pocket [chemical binding]; other site 1037911009092 putative dimerization interface [polypeptide binding]; other site 1037911009093 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911009094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911009097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911009098 DNA binding site [nucleotide binding] 1037911009099 Predicted ATPase [General function prediction only]; Region: COG3903 1037911009100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911009101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911009102 DNA binding site [nucleotide binding] 1037911009103 Predicted ATPase [General function prediction only]; Region: COG3903 1037911009104 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911009105 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1037911009106 conserved cys residue [active] 1037911009107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009109 Pirin-related protein [General function prediction only]; Region: COG1741 1037911009110 Pirin; Region: Pirin; pfam02678 1037911009111 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911009112 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1037911009113 conserved cys residue [active] 1037911009114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009116 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1037911009117 active site 1037911009118 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1037911009119 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1037911009120 active site 1037911009121 dimer interface [polypeptide binding]; other site 1037911009122 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1037911009123 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1037911009124 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911009125 catalytic residue [active] 1037911009126 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1037911009127 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1037911009128 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1037911009129 active site 1037911009130 cosubstrate binding site; other site 1037911009131 substrate binding site [chemical binding]; other site 1037911009132 catalytic site [active] 1037911009133 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1037911009134 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1037911009135 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1037911009136 Walker A/P-loop; other site 1037911009137 ATP binding site [chemical binding]; other site 1037911009138 Q-loop/lid; other site 1037911009139 ABC transporter signature motif; other site 1037911009140 Walker B; other site 1037911009141 D-loop; other site 1037911009142 H-loop/switch region; other site 1037911009143 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911009144 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1037911009145 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911009146 N-terminal plug; other site 1037911009147 ligand-binding site [chemical binding]; other site 1037911009148 Condensation domain; Region: Condensation; pfam00668 1037911009149 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1037911009150 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911009151 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911009152 acyl-activating enzyme (AAE) consensus motif; other site 1037911009153 AMP binding site [chemical binding]; other site 1037911009154 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911009155 Condensation domain; Region: Condensation; pfam00668 1037911009156 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1037911009157 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911009158 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911009159 acyl-activating enzyme (AAE) consensus motif; other site 1037911009160 AMP binding site [chemical binding]; other site 1037911009161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911009162 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1037911009163 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911009164 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911009165 acyl-activating enzyme (AAE) consensus motif; other site 1037911009166 AMP binding site [chemical binding]; other site 1037911009167 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911009168 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1037911009169 Condensation domain; Region: Condensation; pfam00668 1037911009170 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1037911009171 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911009172 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911009173 acyl-activating enzyme (AAE) consensus motif; other site 1037911009174 AMP binding site [chemical binding]; other site 1037911009175 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911009176 Condensation domain; Region: Condensation; pfam00668 1037911009177 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1037911009178 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1037911009179 Condensation domain; Region: Condensation; pfam00668 1037911009180 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911009181 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1037911009182 acyl-activating enzyme (AAE) consensus motif; other site 1037911009183 AMP binding site [chemical binding]; other site 1037911009184 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911009185 Condensation domain; Region: Condensation; pfam00668 1037911009186 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1037911009187 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911009188 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911009189 acyl-activating enzyme (AAE) consensus motif; other site 1037911009190 AMP binding site [chemical binding]; other site 1037911009191 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911009192 Condensation domain; Region: Condensation; pfam00668 1037911009193 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1037911009194 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911009195 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911009196 acyl-activating enzyme (AAE) consensus motif; other site 1037911009197 AMP binding site [chemical binding]; other site 1037911009198 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911009199 YcfA-like protein; Region: YcfA; cl00752 1037911009200 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1037911009201 HicB family; Region: HicB; pfam05534 1037911009202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911009203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911009204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911009205 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1037911009206 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1037911009207 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1037911009208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911009209 putative DNA binding site [nucleotide binding]; other site 1037911009210 putative Zn2+ binding site [ion binding]; other site 1037911009211 Bacterial transcriptional regulator; Region: IclR; pfam01614 1037911009212 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1037911009213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911009214 Walker A/P-loop; other site 1037911009215 ATP binding site [chemical binding]; other site 1037911009216 Q-loop/lid; other site 1037911009217 ABC transporter signature motif; other site 1037911009218 Walker B; other site 1037911009219 D-loop; other site 1037911009220 H-loop/switch region; other site 1037911009221 TOBE domain; Region: TOBE_2; pfam08402 1037911009222 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1037911009223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911009224 dimer interface [polypeptide binding]; other site 1037911009225 conserved gate region; other site 1037911009226 putative PBP binding loops; other site 1037911009227 ABC-ATPase subunit interface; other site 1037911009228 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1037911009229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911009230 dimer interface [polypeptide binding]; other site 1037911009231 conserved gate region; other site 1037911009232 putative PBP binding loops; other site 1037911009233 ABC-ATPase subunit interface; other site 1037911009234 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1037911009235 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1037911009236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911009237 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1037911009238 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911009239 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1037911009240 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1037911009241 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1037911009242 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1037911009243 catalytic triad [active] 1037911009244 metal binding site [ion binding]; metal-binding site 1037911009245 conserved cis-peptide bond; other site 1037911009246 sorbitol dehydrogenase; Provisional; Region: PRK07067 1037911009247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911009248 NAD(P) binding site [chemical binding]; other site 1037911009249 active site 1037911009250 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911009251 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911009252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009253 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1037911009254 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1037911009255 Purine nucleoside permease (NUP); Region: NUP; pfam06516 1037911009256 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1037911009257 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1037911009258 putative NAD(P) binding site [chemical binding]; other site 1037911009259 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1037911009260 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911009261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911009262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009264 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1037911009265 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1037911009266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911009267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911009268 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911009269 putative effector binding pocket; other site 1037911009270 dimerization interface [polypeptide binding]; other site 1037911009271 manganese transport protein MntH; Reviewed; Region: PRK00701 1037911009272 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1037911009273 Protein of unknown function (DUF726); Region: DUF726; pfam05277 1037911009274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1037911009275 hypothetical protein; Provisional; Region: PRK10236 1037911009276 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911009277 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1037911009278 conserved cys residue [active] 1037911009279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009280 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1037911009281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911009282 putative arabinose transporter; Provisional; Region: PRK03545 1037911009283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911009284 putative substrate translocation pore; other site 1037911009285 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1037911009286 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1037911009287 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1037911009288 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911009289 Helix-turn-helix domain; Region: HTH_18; pfam12833 1037911009290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911009291 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1037911009292 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1037911009293 NAD binding site [chemical binding]; other site 1037911009294 catalytic Zn binding site [ion binding]; other site 1037911009295 structural Zn binding site [ion binding]; other site 1037911009296 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1037911009297 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1037911009298 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1037911009299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911009300 S-adenosylmethionine binding site [chemical binding]; other site 1037911009301 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1037911009302 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1037911009303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1037911009304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911009305 dimer interface [polypeptide binding]; other site 1037911009306 conserved gate region; other site 1037911009307 putative PBP binding loops; other site 1037911009308 ABC-ATPase subunit interface; other site 1037911009309 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1037911009310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911009311 putative PBP binding loops; other site 1037911009312 dimer interface [polypeptide binding]; other site 1037911009313 ABC-ATPase subunit interface; other site 1037911009314 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1037911009315 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1037911009316 Walker A/P-loop; other site 1037911009317 ATP binding site [chemical binding]; other site 1037911009318 Q-loop/lid; other site 1037911009319 ABC transporter signature motif; other site 1037911009320 Walker B; other site 1037911009321 D-loop; other site 1037911009322 H-loop/switch region; other site 1037911009323 TOBE domain; Region: TOBE_2; pfam08402 1037911009324 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1037911009325 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1037911009326 Walker A/P-loop; other site 1037911009327 ATP binding site [chemical binding]; other site 1037911009328 Q-loop/lid; other site 1037911009329 ABC transporter signature motif; other site 1037911009330 Walker B; other site 1037911009331 D-loop; other site 1037911009332 H-loop/switch region; other site 1037911009333 TOBE domain; Region: TOBE_2; pfam08402 1037911009334 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1037911009335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911009336 Walker A motif; other site 1037911009337 ATP binding site [chemical binding]; other site 1037911009338 Walker B motif; other site 1037911009339 arginine finger; other site 1037911009340 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1037911009341 DNA-binding interface [nucleotide binding]; DNA binding site 1037911009342 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911009343 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1037911009344 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1037911009345 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 1037911009346 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1037911009347 YccA-like proteins; Region: YccA_like; cd10433 1037911009348 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1037911009349 FAD binding domain; Region: FAD_binding_4; pfam01565 1037911009350 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1037911009351 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1037911009352 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1037911009353 active site 1037911009354 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1037911009355 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1037911009356 Ligand binding site; other site 1037911009357 oligomer interface; other site 1037911009358 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1037911009359 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1037911009360 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1037911009361 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1037911009362 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1037911009363 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1037911009364 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1037911009365 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1037911009366 Competence protein; Region: Competence; pfam03772 1037911009367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1037911009368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 1037911009369 CopC domain; Region: CopC; cl01012 1037911009370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911009371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911009372 dimerization interface [polypeptide binding]; other site 1037911009373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911009374 dimer interface [polypeptide binding]; other site 1037911009375 phosphorylation site [posttranslational modification] 1037911009376 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 1037911009377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911009378 ATP binding site [chemical binding]; other site 1037911009379 Mg2+ binding site [ion binding]; other site 1037911009380 G-X-G motif; other site 1037911009381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911009382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911009383 active site 1037911009384 phosphorylation site [posttranslational modification] 1037911009385 intermolecular recognition site; other site 1037911009386 dimerization interface [polypeptide binding]; other site 1037911009387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911009388 DNA binding site [nucleotide binding] 1037911009389 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1037911009390 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911009391 dimerization interface [polypeptide binding]; other site 1037911009392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911009393 dimer interface [polypeptide binding]; other site 1037911009394 phosphorylation site [posttranslational modification] 1037911009395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911009396 ATP binding site [chemical binding]; other site 1037911009397 Mg2+ binding site [ion binding]; other site 1037911009398 G-X-G motif; other site 1037911009399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911009400 active site 1037911009401 phosphorylation site [posttranslational modification] 1037911009402 intermolecular recognition site; other site 1037911009403 dimerization interface [polypeptide binding]; other site 1037911009404 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911009405 putative binding surface; other site 1037911009406 active site 1037911009407 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1037911009408 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1037911009409 putative ligand binding site [chemical binding]; other site 1037911009410 putative NAD binding site [chemical binding]; other site 1037911009411 catalytic site [active] 1037911009412 META domain; Region: META; pfam03724 1037911009413 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1037911009414 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1037911009415 catalytic residues [active] 1037911009416 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1037911009417 ArsC family; Region: ArsC; pfam03960 1037911009418 catalytic residues [active] 1037911009419 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1037911009420 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1037911009421 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 1037911009422 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 1037911009423 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1037911009424 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1037911009425 Ligand Binding Site [chemical binding]; other site 1037911009426 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1037911009427 hypothetical protein; Provisional; Region: PRK04860 1037911009428 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1037911009429 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1037911009430 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1037911009431 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1037911009432 sulfur relay protein TusC; Validated; Region: PRK00211 1037911009433 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 1037911009434 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1037911009435 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 1037911009436 hypothetical protein; Validated; Region: PRK09071 1037911009437 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1037911009438 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1037911009439 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1037911009440 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1037911009441 putative dimer interface [polypeptide binding]; other site 1037911009442 N-terminal domain interface [polypeptide binding]; other site 1037911009443 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911009444 siroheme synthase; Provisional; Region: cysG; PRK10637 1037911009445 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1037911009446 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1037911009447 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1037911009448 active site 1037911009449 SAM binding site [chemical binding]; other site 1037911009450 homodimer interface [polypeptide binding]; other site 1037911009451 seryl-tRNA synthetase; Provisional; Region: PRK05431 1037911009452 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1037911009453 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1037911009454 dimer interface [polypeptide binding]; other site 1037911009455 active site 1037911009456 motif 1; other site 1037911009457 motif 2; other site 1037911009458 motif 3; other site 1037911009459 camphor resistance protein CrcB; Provisional; Region: PRK14234 1037911009460 recombination factor protein RarA; Reviewed; Region: PRK13342 1037911009461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911009462 Walker A motif; other site 1037911009463 ATP binding site [chemical binding]; other site 1037911009464 Walker B motif; other site 1037911009465 arginine finger; other site 1037911009466 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1037911009467 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1037911009468 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1037911009469 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1037911009470 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1037911009471 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1037911009472 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1037911009473 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1037911009474 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1037911009475 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1037911009476 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1037911009477 rRNA binding site [nucleotide binding]; other site 1037911009478 predicted 30S ribosome binding site; other site 1037911009479 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1037911009480 Clp amino terminal domain; Region: Clp_N; pfam02861 1037911009481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911009482 Walker A motif; other site 1037911009483 ATP binding site [chemical binding]; other site 1037911009484 Walker B motif; other site 1037911009485 arginine finger; other site 1037911009486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911009487 Walker A motif; other site 1037911009488 ATP binding site [chemical binding]; other site 1037911009489 Walker B motif; other site 1037911009490 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1037911009491 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1037911009492 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1037911009493 DNA-binding site [nucleotide binding]; DNA binding site 1037911009494 RNA-binding motif; other site 1037911009495 isocitrate dehydrogenase; Validated; Region: PRK07362 1037911009496 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1037911009497 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1037911009498 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1037911009499 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1037911009500 nudix motif; other site 1037911009501 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1037911009502 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1037911009503 putative lysogenization regulator; Reviewed; Region: PRK00218 1037911009504 adenylosuccinate lyase; Provisional; Region: PRK09285 1037911009505 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1037911009506 tetramer interface [polypeptide binding]; other site 1037911009507 active site 1037911009508 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1037911009509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911009510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911009511 Coenzyme A binding pocket [chemical binding]; other site 1037911009512 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1037911009513 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1037911009514 isocitrate lyase; Provisional; Region: PRK15063 1037911009515 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1037911009516 tetramer interface [polypeptide binding]; other site 1037911009517 active site 1037911009518 Mg2+/Mn2+ binding site [ion binding]; other site 1037911009519 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1037911009520 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1037911009521 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1037911009522 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1037911009523 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1037911009524 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1037911009525 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1037911009526 putative dimer interface [polypeptide binding]; other site 1037911009527 [2Fe-2S] cluster binding site [ion binding]; other site 1037911009528 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1037911009529 SLBB domain; Region: SLBB; pfam10531 1037911009530 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1037911009531 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911009532 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 1037911009533 catalytic loop [active] 1037911009534 iron binding site [ion binding]; other site 1037911009535 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1037911009536 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1037911009537 [4Fe-4S] binding site [ion binding]; other site 1037911009538 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1037911009539 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1037911009540 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1037911009541 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1037911009542 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1037911009543 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1037911009544 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1037911009545 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1037911009546 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1037911009547 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1037911009548 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1037911009549 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1037911009550 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1037911009551 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1037911009552 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1037911009553 Predicted transcriptional regulator [Transcription]; Region: COG2944 1037911009554 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1037911009555 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1037911009556 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 1037911009557 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 1037911009558 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1037911009559 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1037911009560 tetrameric interface [polypeptide binding]; other site 1037911009561 activator binding site; other site 1037911009562 NADP binding site [chemical binding]; other site 1037911009563 substrate binding site [chemical binding]; other site 1037911009564 catalytic residues [active] 1037911009565 Predicted membrane protein [Function unknown]; Region: COG1289 1037911009566 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1037911009567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911009568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911009569 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1037911009570 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1037911009571 Walker A/P-loop; other site 1037911009572 ATP binding site [chemical binding]; other site 1037911009573 Q-loop/lid; other site 1037911009574 ABC transporter signature motif; other site 1037911009575 Walker B; other site 1037911009576 D-loop; other site 1037911009577 H-loop/switch region; other site 1037911009578 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1037911009579 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1037911009580 FtsX-like permease family; Region: FtsX; pfam02687 1037911009581 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1037911009582 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911009583 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911009584 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911009585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1037911009586 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1037911009587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911009588 non-specific DNA binding site [nucleotide binding]; other site 1037911009589 salt bridge; other site 1037911009590 sequence-specific DNA binding site [nucleotide binding]; other site 1037911009591 Cupin domain; Region: Cupin_2; pfam07883 1037911009592 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1037911009593 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1037911009594 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1037911009595 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1037911009596 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1037911009597 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1037911009598 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1037911009599 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1037911009600 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1037911009601 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1037911009602 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1037911009603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1037911009604 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1037911009605 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1037911009606 active site 1037911009607 HIGH motif; other site 1037911009608 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1037911009609 KMSKS motif; other site 1037911009610 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1037911009611 tRNA binding surface [nucleotide binding]; other site 1037911009612 anticodon binding site; other site 1037911009613 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1037911009614 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1037911009615 active site 1037911009616 HIGH motif; other site 1037911009617 nucleotide binding site [chemical binding]; other site 1037911009618 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1037911009619 KMSKS motif; other site 1037911009620 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1037911009621 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1037911009622 substrate binding site [chemical binding]; other site 1037911009623 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1037911009624 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1037911009625 putative active site [active] 1037911009626 putative metal binding site [ion binding]; other site 1037911009627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911009628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911009629 putative substrate translocation pore; other site 1037911009630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911009631 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1037911009632 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911009633 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911009634 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1037911009635 MarR family; Region: MarR_2; cl17246 1037911009636 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1037911009637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1037911009638 Family of unknown function (DUF490); Region: DUF490; pfam04357 1037911009639 Family of unknown function (DUF490); Region: DUF490; pfam04357 1037911009640 Family of unknown function (DUF490); Region: DUF490; pfam04357 1037911009641 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1037911009642 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1037911009643 Surface antigen; Region: Bac_surface_Ag; pfam01103 1037911009644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1037911009645 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1037911009646 putative catalytic site [active] 1037911009647 putative phosphate binding site [ion binding]; other site 1037911009648 active site 1037911009649 metal binding site A [ion binding]; metal-binding site 1037911009650 DNA binding site [nucleotide binding] 1037911009651 putative AP binding site [nucleotide binding]; other site 1037911009652 putative metal binding site B [ion binding]; other site 1037911009653 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1037911009654 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1037911009655 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911009656 ligand binding site [chemical binding]; other site 1037911009657 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911009658 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1037911009659 FAD binding site [chemical binding]; other site 1037911009660 substrate binding site [chemical binding]; other site 1037911009661 catalytic base [active] 1037911009662 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1037911009663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911009664 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1037911009665 substrate binding pocket [chemical binding]; other site 1037911009666 dimerization interface [polypeptide binding]; other site 1037911009667 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1037911009668 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1037911009669 DNA binding residues [nucleotide binding] 1037911009670 putative dimer interface [polypeptide binding]; other site 1037911009671 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1037911009672 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1037911009673 active site 1037911009674 catalytic residues [active] 1037911009675 metal binding site [ion binding]; metal-binding site 1037911009676 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1037911009677 AMP-binding enzyme; Region: AMP-binding; pfam00501 1037911009678 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1037911009679 acyl-activating enzyme (AAE) consensus motif; other site 1037911009680 acyl-activating enzyme (AAE) consensus motif; other site 1037911009681 putative active site [active] 1037911009682 putative AMP binding site [chemical binding]; other site 1037911009683 putative CoA binding site [chemical binding]; other site 1037911009684 isovaleryl-CoA dehydrogenase; Region: PLN02519 1037911009685 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1037911009686 substrate binding site [chemical binding]; other site 1037911009687 FAD binding site [chemical binding]; other site 1037911009688 catalytic base [active] 1037911009689 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1037911009690 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1037911009691 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1037911009692 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1037911009693 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911009694 substrate binding site [chemical binding]; other site 1037911009695 oxyanion hole (OAH) forming residues; other site 1037911009696 trimer interface [polypeptide binding]; other site 1037911009697 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1037911009698 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1037911009699 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1037911009700 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1037911009701 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1037911009702 E3 interaction surface; other site 1037911009703 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1037911009704 carboxyltransferase (CT) interaction site; other site 1037911009705 biotinylation site [posttranslational modification]; other site 1037911009706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911009707 non-specific DNA binding site [nucleotide binding]; other site 1037911009708 salt bridge; other site 1037911009709 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1037911009710 sequence-specific DNA binding site [nucleotide binding]; other site 1037911009711 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1037911009712 Catalytic site [active] 1037911009713 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1037911009714 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1037911009715 active site 1037911009716 Zn binding site [ion binding]; other site 1037911009717 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1037911009718 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1037911009719 putative heme binding pocket [chemical binding]; other site 1037911009720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911009721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911009722 DNA binding residues [nucleotide binding] 1037911009723 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1037911009724 Spore Coat Protein U domain; Region: SCPU; pfam05229 1037911009725 Spore Coat Protein U domain; Region: SCPU; pfam05229 1037911009726 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1037911009727 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1037911009728 PapC C-terminal domain; Region: PapC_C; pfam13953 1037911009729 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1037911009730 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1037911009731 Spore Coat Protein U domain; Region: SCPU; pfam05229 1037911009732 Spore Coat Protein U domain; Region: SCPU; pfam05229 1037911009733 Spore Coat Protein U domain; Region: SCPU; pfam05229 1037911009734 Spore Coat Protein U domain; Region: SCPU; pfam05229 1037911009735 Predicted ATPase [General function prediction only]; Region: COG1485 1037911009736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1037911009737 Walker A motif; other site 1037911009738 ATP binding site [chemical binding]; other site 1037911009739 Walker B motif; other site 1037911009740 arginine finger; other site 1037911009741 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1037911009742 Leucine rich repeat; Region: LRR_8; pfam13855 1037911009743 Substrate binding site [chemical binding]; other site 1037911009744 Leucine rich repeat; Region: LRR_8; pfam13855 1037911009745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1037911009746 active site 1037911009747 ATP binding site [chemical binding]; other site 1037911009748 substrate binding site [chemical binding]; other site 1037911009749 activation loop (A-loop); other site 1037911009750 hypothetical protein; Provisional; Region: PRK12378 1037911009751 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1037911009752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911009753 putative substrate translocation pore; other site 1037911009754 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1037911009755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911009756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911009757 dimerization interface [polypeptide binding]; other site 1037911009758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911009759 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1037911009760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911009761 dimerization interface [polypeptide binding]; other site 1037911009762 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1037911009763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911009764 catalytic residue [active] 1037911009765 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1037911009766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911009767 motif II; other site 1037911009768 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1037911009769 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1037911009770 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1037911009771 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911009772 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1037911009773 active site 1037911009774 FMN binding site [chemical binding]; other site 1037911009775 2,4-decadienoyl-CoA binding site; other site 1037911009776 catalytic residue [active] 1037911009777 4Fe-4S cluster binding site [ion binding]; other site 1037911009778 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1037911009779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1037911009780 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1037911009781 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1037911009782 active site 1037911009783 catalytic triad [active] 1037911009784 dimer interface [polypeptide binding]; other site 1037911009785 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1037911009786 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911009787 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 1037911009788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911009789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911009790 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1037911009791 putative effector binding pocket; other site 1037911009792 putative dimerization interface [polypeptide binding]; other site 1037911009793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911009794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911009795 putative substrate translocation pore; other site 1037911009796 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1037911009797 periplasmic folding chaperone; Provisional; Region: PRK10788 1037911009798 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1037911009799 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1037911009800 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1037911009801 IHF - DNA interface [nucleotide binding]; other site 1037911009802 IHF dimer interface [polypeptide binding]; other site 1037911009803 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1037911009804 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1037911009805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911009806 Walker A motif; other site 1037911009807 ATP binding site [chemical binding]; other site 1037911009808 Walker B motif; other site 1037911009809 arginine finger; other site 1037911009810 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1037911009811 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1037911009812 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1037911009813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911009814 Walker A motif; other site 1037911009815 ATP binding site [chemical binding]; other site 1037911009816 Walker B motif; other site 1037911009817 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1037911009818 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1037911009819 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1037911009820 oligomer interface [polypeptide binding]; other site 1037911009821 active site residues [active] 1037911009822 trigger factor; Provisional; Region: tig; PRK01490 1037911009823 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1037911009824 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1037911009825 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1037911009826 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1037911009827 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1037911009828 homodimer interface [polypeptide binding]; other site 1037911009829 NADP binding site [chemical binding]; other site 1037911009830 substrate binding site [chemical binding]; other site 1037911009831 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1037911009832 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1037911009833 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1037911009834 putative active site [active] 1037911009835 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1037911009836 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1037911009837 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1037911009838 E3 interaction surface; other site 1037911009839 lipoyl attachment site [posttranslational modification]; other site 1037911009840 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911009841 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1037911009842 allantoate amidohydrolase; Reviewed; Region: PRK12893 1037911009843 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1037911009844 active site 1037911009845 metal binding site [ion binding]; metal-binding site 1037911009846 dimer interface [polypeptide binding]; other site 1037911009847 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1037911009848 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1037911009849 Na binding site [ion binding]; other site 1037911009850 putative substrate binding site [chemical binding]; other site 1037911009851 phenylhydantoinase; Validated; Region: PRK08323 1037911009852 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1037911009853 tetramer interface [polypeptide binding]; other site 1037911009854 active site 1037911009855 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1037911009856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911009857 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1037911009858 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1037911009859 homodimer interface [polypeptide binding]; other site 1037911009860 active site 1037911009861 FMN binding site [chemical binding]; other site 1037911009862 substrate binding site [chemical binding]; other site 1037911009863 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1037911009864 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1037911009865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911009866 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1037911009867 CopC domain; Region: CopC; pfam04234 1037911009868 Copper resistance protein D; Region: CopD; cl00563 1037911009869 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911009870 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1037911009871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911009872 active site 1037911009873 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1037911009874 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1037911009875 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1037911009876 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1037911009877 DctM-like transporters; Region: DctM; pfam06808 1037911009878 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1037911009879 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1037911009880 active site 1037911009881 catalytic residues [active] 1037911009882 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1037911009883 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911009884 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911009885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911009886 putative substrate translocation pore; other site 1037911009887 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1037911009888 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1037911009889 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1037911009890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911009891 putative DNA binding site [nucleotide binding]; other site 1037911009892 dimerization interface [polypeptide binding]; other site 1037911009893 putative Zn2+ binding site [ion binding]; other site 1037911009894 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1037911009895 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1037911009896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911009897 putative DNA binding site [nucleotide binding]; other site 1037911009898 putative Zn2+ binding site [ion binding]; other site 1037911009899 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911009900 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1037911009901 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1037911009902 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1037911009903 tetramer interface [polypeptide binding]; other site 1037911009904 TPP-binding site [chemical binding]; other site 1037911009905 heterodimer interface [polypeptide binding]; other site 1037911009906 phosphorylation loop region [posttranslational modification] 1037911009907 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1037911009908 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1037911009909 alpha subunit interface [polypeptide binding]; other site 1037911009910 TPP binding site [chemical binding]; other site 1037911009911 heterodimer interface [polypeptide binding]; other site 1037911009912 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1037911009913 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1037911009914 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1037911009915 E3 interaction surface; other site 1037911009916 lipoyl attachment site [posttranslational modification]; other site 1037911009917 e3 binding domain; Region: E3_binding; pfam02817 1037911009918 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1037911009919 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1037911009920 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911009921 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1037911009922 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1037911009923 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1037911009924 homodimer interface [polypeptide binding]; other site 1037911009925 substrate-cofactor binding pocket; other site 1037911009926 catalytic residue [active] 1037911009927 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1037911009928 putative acetyltransferase; Provisional; Region: PRK03624 1037911009929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911009930 Coenzyme A binding pocket [chemical binding]; other site 1037911009931 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1037911009932 Amidinotransferase; Region: Amidinotransf; pfam02274 1037911009933 ornithine cyclodeaminase; Validated; Region: PRK07589 1037911009934 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1037911009935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911009936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911009937 substrate binding pocket [chemical binding]; other site 1037911009938 membrane-bound complex binding site; other site 1037911009939 hinge residues; other site 1037911009940 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911009941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911009942 dimer interface [polypeptide binding]; other site 1037911009943 conserved gate region; other site 1037911009944 putative PBP binding loops; other site 1037911009945 ABC-ATPase subunit interface; other site 1037911009946 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911009947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911009948 dimer interface [polypeptide binding]; other site 1037911009949 conserved gate region; other site 1037911009950 putative PBP binding loops; other site 1037911009951 ABC-ATPase subunit interface; other site 1037911009952 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1037911009953 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911009954 Walker A/P-loop; other site 1037911009955 ATP binding site [chemical binding]; other site 1037911009956 Q-loop/lid; other site 1037911009957 ABC transporter signature motif; other site 1037911009958 Walker B; other site 1037911009959 D-loop; other site 1037911009960 H-loop/switch region; other site 1037911009961 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1037911009962 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1037911009963 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911009964 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 1037911009965 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 1037911009966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911009967 FeS/SAM binding site; other site 1037911009968 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1037911009969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1037911009970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911009971 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1037911009972 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1037911009973 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1037911009974 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911009975 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911009976 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1037911009977 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1037911009978 Walker A/P-loop; other site 1037911009979 ATP binding site [chemical binding]; other site 1037911009980 Q-loop/lid; other site 1037911009981 ABC transporter signature motif; other site 1037911009982 Walker B; other site 1037911009983 D-loop; other site 1037911009984 H-loop/switch region; other site 1037911009985 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1037911009986 FtsX-like permease family; Region: FtsX; pfam02687 1037911009987 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1037911009988 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1037911009989 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911009990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911009991 DNA-binding site [nucleotide binding]; DNA binding site 1037911009992 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1037911009993 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1037911009994 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1037911009995 putative ligand binding site [chemical binding]; other site 1037911009996 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911009997 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1037911009998 TM-ABC transporter signature motif; other site 1037911009999 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1037911010000 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1037911010001 TM-ABC transporter signature motif; other site 1037911010002 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1037911010003 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1037911010004 Walker A/P-loop; other site 1037911010005 ATP binding site [chemical binding]; other site 1037911010006 Q-loop/lid; other site 1037911010007 ABC transporter signature motif; other site 1037911010008 Walker B; other site 1037911010009 D-loop; other site 1037911010010 H-loop/switch region; other site 1037911010011 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1037911010012 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1037911010013 Walker A/P-loop; other site 1037911010014 ATP binding site [chemical binding]; other site 1037911010015 Q-loop/lid; other site 1037911010016 ABC transporter signature motif; other site 1037911010017 Walker B; other site 1037911010018 D-loop; other site 1037911010019 H-loop/switch region; other site 1037911010020 allantoate amidohydrolase; Reviewed; Region: PRK12893 1037911010021 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1037911010022 active site 1037911010023 metal binding site [ion binding]; metal-binding site 1037911010024 dimer interface [polypeptide binding]; other site 1037911010025 putative amidase; Provisional; Region: PRK06169 1037911010026 Amidase; Region: Amidase; pfam01425 1037911010027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911010028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010029 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1037911010030 dimerization interface [polypeptide binding]; other site 1037911010031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1037911010032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1037911010033 DNA binding site [nucleotide binding] 1037911010034 domain linker motif; other site 1037911010035 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1037911010036 dimerization interface [polypeptide binding]; other site 1037911010037 ligand binding site [chemical binding]; other site 1037911010038 short chain dehydrogenase; Provisional; Region: PRK07060 1037911010039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911010040 NAD(P) binding site [chemical binding]; other site 1037911010041 active site 1037911010042 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1037911010043 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 1037911010044 N- and C-terminal domain interface [polypeptide binding]; other site 1037911010045 putative active site [active] 1037911010046 MgATP binding site [chemical binding]; other site 1037911010047 catalytic site [active] 1037911010048 metal binding site [ion binding]; metal-binding site 1037911010049 putative xylulose binding site [chemical binding]; other site 1037911010050 putative homodimer interface [polypeptide binding]; other site 1037911010051 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1037911010052 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1037911010053 NAD(P) binding site [chemical binding]; other site 1037911010054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911010055 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1037911010056 TM-ABC transporter signature motif; other site 1037911010057 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1037911010058 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1037911010059 Walker A/P-loop; other site 1037911010060 ATP binding site [chemical binding]; other site 1037911010061 Q-loop/lid; other site 1037911010062 ABC transporter signature motif; other site 1037911010063 Walker B; other site 1037911010064 D-loop; other site 1037911010065 H-loop/switch region; other site 1037911010066 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1037911010067 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1037911010068 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1037911010069 putative ligand binding site [chemical binding]; other site 1037911010070 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1037911010071 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1037911010072 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1037911010073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1037911010074 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1037911010075 Walker A/P-loop; other site 1037911010076 ATP binding site [chemical binding]; other site 1037911010077 Q-loop/lid; other site 1037911010078 ABC transporter signature motif; other site 1037911010079 Walker B; other site 1037911010080 D-loop; other site 1037911010081 H-loop/switch region; other site 1037911010082 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1037911010083 catalytic core [active] 1037911010084 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1037911010085 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1037911010086 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1037911010087 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1037911010088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911010089 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1037911010090 Walker A/P-loop; other site 1037911010091 ATP binding site [chemical binding]; other site 1037911010092 Q-loop/lid; other site 1037911010093 ABC transporter signature motif; other site 1037911010094 Walker B; other site 1037911010095 D-loop; other site 1037911010096 H-loop/switch region; other site 1037911010097 YcaO-like family; Region: YcaO; pfam02624 1037911010098 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1037911010099 putative FMN binding site [chemical binding]; other site 1037911010100 NADPH bind site [chemical binding]; other site 1037911010101 Condensation domain; Region: Condensation; pfam00668 1037911010102 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911010103 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911010104 DNA binding residues [nucleotide binding] 1037911010105 dimerization interface [polypeptide binding]; other site 1037911010106 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1037911010107 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1037911010108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911010109 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1037911010110 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1037911010111 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1037911010112 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1037911010113 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1037911010114 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1037911010115 NAD binding site [chemical binding]; other site 1037911010116 catalytic residues [active] 1037911010117 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1037911010118 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1037911010119 putative active site [active] 1037911010120 putative metal binding site [ion binding]; other site 1037911010121 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1037911010122 putative substrate binding pocket [chemical binding]; other site 1037911010123 trimer interface [polypeptide binding]; other site 1037911010124 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1037911010125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911010126 putative substrate translocation pore; other site 1037911010127 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1037911010128 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1037911010129 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1037911010130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1037911010131 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1037911010132 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911010133 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1037911010134 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1037911010135 classical (c) SDRs; Region: SDR_c; cd05233 1037911010136 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1037911010137 NAD(P) binding site [chemical binding]; other site 1037911010138 active site 1037911010139 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1037911010140 classical (c) SDRs; Region: SDR_c; cd05233 1037911010141 NAD(P) binding site [chemical binding]; other site 1037911010142 active site 1037911010143 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1037911010144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911010145 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1037911010146 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1037911010147 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1037911010148 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1037911010149 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911010150 Flavin binding site [chemical binding]; other site 1037911010151 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1037911010152 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1037911010153 NAD(P) binding site [chemical binding]; other site 1037911010154 catalytic residues [active] 1037911010155 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1037911010156 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1037911010157 transcriptional regulator; Provisional; Region: PRK10632 1037911010158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911010160 dimerization interface [polypeptide binding]; other site 1037911010161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911010162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010163 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1037911010164 putative effector binding pocket; other site 1037911010165 putative dimerization interface [polypeptide binding]; other site 1037911010166 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911010167 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1037911010168 putative C-terminal domain interface [polypeptide binding]; other site 1037911010169 putative GSH binding site (G-site) [chemical binding]; other site 1037911010170 putative dimer interface [polypeptide binding]; other site 1037911010171 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1037911010172 putative N-terminal domain interface [polypeptide binding]; other site 1037911010173 putative dimer interface [polypeptide binding]; other site 1037911010174 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911010175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1037911010176 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1037911010177 active site 1037911010178 catalytic tetrad [active] 1037911010179 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1037911010180 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1037911010181 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1037911010182 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1037911010183 Fimbrial protein; Region: Fimbrial; pfam00419 1037911010184 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1037911010185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911010186 dimer interface [polypeptide binding]; other site 1037911010187 phosphorylation site [posttranslational modification] 1037911010188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911010189 ATP binding site [chemical binding]; other site 1037911010190 Mg2+ binding site [ion binding]; other site 1037911010191 G-X-G motif; other site 1037911010192 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911010193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911010194 active site 1037911010195 phosphorylation site [posttranslational modification] 1037911010196 intermolecular recognition site; other site 1037911010197 dimerization interface [polypeptide binding]; other site 1037911010198 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911010199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911010200 active site 1037911010201 phosphorylation site [posttranslational modification] 1037911010202 intermolecular recognition site; other site 1037911010203 dimerization interface [polypeptide binding]; other site 1037911010204 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911010205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911010206 dimer interface [polypeptide binding]; other site 1037911010207 phosphorylation site [posttranslational modification] 1037911010208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911010209 ATP binding site [chemical binding]; other site 1037911010210 Mg2+ binding site [ion binding]; other site 1037911010211 G-X-G motif; other site 1037911010212 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911010213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911010214 active site 1037911010215 phosphorylation site [posttranslational modification] 1037911010216 intermolecular recognition site; other site 1037911010217 dimerization interface [polypeptide binding]; other site 1037911010218 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911010219 putative binding surface; other site 1037911010220 active site 1037911010221 transcriptional regulator RcsB; Provisional; Region: PRK10840 1037911010222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911010223 active site 1037911010224 phosphorylation site [posttranslational modification] 1037911010225 intermolecular recognition site; other site 1037911010226 dimerization interface [polypeptide binding]; other site 1037911010227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911010228 DNA binding residues [nucleotide binding] 1037911010229 dimerization interface [polypeptide binding]; other site 1037911010230 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1037911010231 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1037911010232 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1037911010233 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1037911010234 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1037911010235 PapC N-terminal domain; Region: PapC_N; pfam13954 1037911010236 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1037911010237 PapC C-terminal domain; Region: PapC_C; pfam13953 1037911010238 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1037911010239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911010240 active site 1037911010241 motif I; other site 1037911010242 motif II; other site 1037911010243 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1037911010244 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1037911010245 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1037911010246 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1037911010247 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1037911010248 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1037911010249 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1037911010250 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1037911010251 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1037911010252 general secretion pathway protein J; Validated; Region: PRK08808 1037911010253 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1037911010254 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1037911010255 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1037911010256 type II secretion system protein F; Region: GspF; TIGR02120 1037911010257 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1037911010258 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1037911010259 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1037911010260 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1037911010261 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1037911010262 Walker A motif; other site 1037911010263 ATP binding site [chemical binding]; other site 1037911010264 Walker B motif; other site 1037911010265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1037911010266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1037911010267 DNA binding site [nucleotide binding] 1037911010268 domain linker motif; other site 1037911010269 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1037911010270 putative ligand binding site [chemical binding]; other site 1037911010271 putative dimerization interface [polypeptide binding]; other site 1037911010272 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911010273 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911010274 N-terminal plug; other site 1037911010275 ligand-binding site [chemical binding]; other site 1037911010276 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1037911010277 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1037911010278 active site 1037911010279 non-prolyl cis peptide bond; other site 1037911010280 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1037911010281 amphipathic channel; other site 1037911010282 Asn-Pro-Ala signature motifs; other site 1037911010283 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1037911010284 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1037911010285 DNA binding residues [nucleotide binding] 1037911010286 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1037911010287 IHF dimer interface [polypeptide binding]; other site 1037911010288 IHF - DNA interface [nucleotide binding]; other site 1037911010289 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1037911010290 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1037911010291 putative tRNA-binding site [nucleotide binding]; other site 1037911010292 B3/4 domain; Region: B3_4; pfam03483 1037911010293 tRNA synthetase B5 domain; Region: B5; smart00874 1037911010294 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1037911010295 dimer interface [polypeptide binding]; other site 1037911010296 motif 1; other site 1037911010297 motif 3; other site 1037911010298 motif 2; other site 1037911010299 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1037911010300 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1037911010301 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1037911010302 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1037911010303 dimer interface [polypeptide binding]; other site 1037911010304 motif 1; other site 1037911010305 active site 1037911010306 motif 2; other site 1037911010307 motif 3; other site 1037911010308 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1037911010309 23S rRNA binding site [nucleotide binding]; other site 1037911010310 L21 binding site [polypeptide binding]; other site 1037911010311 L13 binding site [polypeptide binding]; other site 1037911010312 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1037911010313 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1037911010314 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1037911010315 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1037911010316 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1037911010317 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1037911010318 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1037911010319 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1037911010320 active site 1037911010321 dimer interface [polypeptide binding]; other site 1037911010322 motif 1; other site 1037911010323 motif 2; other site 1037911010324 motif 3; other site 1037911010325 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1037911010326 anticodon binding site; other site 1037911010327 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1037911010328 DNA-binding site [nucleotide binding]; DNA binding site 1037911010329 RNA-binding motif; other site 1037911010330 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1037911010331 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1037911010332 active site 1037911010333 tetramer interface [polypeptide binding]; other site 1037911010334 D-ribose pyranase; Provisional; Region: PRK11797 1037911010335 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1037911010336 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1037911010337 substrate binding site [chemical binding]; other site 1037911010338 dimer interface [polypeptide binding]; other site 1037911010339 ATP binding site [chemical binding]; other site 1037911010340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1037911010341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1037911010342 DNA binding site [nucleotide binding] 1037911010343 domain linker motif; other site 1037911010344 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1037911010345 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911010346 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1037911010347 TM-ABC transporter signature motif; other site 1037911010348 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1037911010349 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1037911010350 Walker A/P-loop; other site 1037911010351 ATP binding site [chemical binding]; other site 1037911010352 Q-loop/lid; other site 1037911010353 ABC transporter signature motif; other site 1037911010354 Walker B; other site 1037911010355 D-loop; other site 1037911010356 H-loop/switch region; other site 1037911010357 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1037911010358 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1037911010359 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1037911010360 ligand binding site [chemical binding]; other site 1037911010361 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1037911010362 homodimer interface [polypeptide binding]; other site 1037911010363 active site 1037911010364 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 1037911010365 DNA-specific endonuclease I; Provisional; Region: PRK15137 1037911010366 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1037911010367 carbon storage regulator; Provisional; Region: PRK01712 1037911010368 putative phosphatase; Provisional; Region: PRK11587 1037911010369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911010370 active site 1037911010371 motif I; other site 1037911010372 motif II; other site 1037911010373 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1037911010374 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1037911010375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911010376 active site 1037911010377 phosphorylation site [posttranslational modification] 1037911010378 intermolecular recognition site; other site 1037911010379 dimerization interface [polypeptide binding]; other site 1037911010380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911010381 DNA binding site [nucleotide binding] 1037911010382 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1037911010383 HAMP domain; Region: HAMP; pfam00672 1037911010384 dimerization interface [polypeptide binding]; other site 1037911010385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911010386 dimer interface [polypeptide binding]; other site 1037911010387 phosphorylation site [posttranslational modification] 1037911010388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911010389 ATP binding site [chemical binding]; other site 1037911010390 G-X-G motif; other site 1037911010391 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1037911010392 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1037911010393 putative substrate binding pocket [chemical binding]; other site 1037911010394 AC domain interface; other site 1037911010395 catalytic triad [active] 1037911010396 AB domain interface; other site 1037911010397 interchain disulfide; other site 1037911010398 Predicted membrane protein [Function unknown]; Region: COG3817 1037911010399 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1037911010400 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1037911010401 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1037911010402 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911010403 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1037911010404 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1037911010405 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1037911010406 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911010407 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911010408 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1037911010409 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1037911010410 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1037911010411 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1037911010412 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1037911010413 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1037911010414 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1037911010415 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1037911010416 oxidoreductase; Validated; Region: PRK05717 1037911010417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911010418 NAD(P) binding site [chemical binding]; other site 1037911010419 active site 1037911010420 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1037911010421 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1037911010422 homodimer interface [polypeptide binding]; other site 1037911010423 substrate-cofactor binding pocket; other site 1037911010424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911010425 catalytic residue [active] 1037911010426 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1037911010427 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1037911010428 active site 1037911010429 tetramer interface [polypeptide binding]; other site 1037911010430 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911010431 active site 1037911010432 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1037911010433 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1037911010434 Colicin V production protein; Region: Colicin_V; cl00567 1037911010435 Sporulation related domain; Region: SPOR; pfam05036 1037911010436 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1037911010437 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1037911010438 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1037911010439 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1037911010440 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1037911010441 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1037911010442 active site 1037911010443 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1037911010444 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1037911010445 dimerization interface 3.5A [polypeptide binding]; other site 1037911010446 active site 1037911010447 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1037911010448 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1037911010449 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1037911010450 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1037911010451 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1037911010452 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1037911010453 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1037911010454 tartrate dehydrogenase; Region: TTC; TIGR02089 1037911010455 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1037911010456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911010457 S-adenosylmethionine binding site [chemical binding]; other site 1037911010458 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1037911010459 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1037911010460 substrate binding site [chemical binding]; other site 1037911010461 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1037911010462 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1037911010463 substrate binding site [chemical binding]; other site 1037911010464 ligand binding site [chemical binding]; other site 1037911010465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911010466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911010468 dimerization interface [polypeptide binding]; other site 1037911010469 PAS fold; Region: PAS_3; pfam08447 1037911010470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911010471 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1037911010472 putative active site [active] 1037911010473 heme pocket [chemical binding]; other site 1037911010474 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1037911010475 PAS domain S-box; Region: sensory_box; TIGR00229 1037911010476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911010477 putative active site [active] 1037911010478 heme pocket [chemical binding]; other site 1037911010479 PAS domain S-box; Region: sensory_box; TIGR00229 1037911010480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911010481 putative active site [active] 1037911010482 heme pocket [chemical binding]; other site 1037911010483 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911010484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911010485 metal binding site [ion binding]; metal-binding site 1037911010486 active site 1037911010487 I-site; other site 1037911010488 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911010489 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1037911010490 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1037911010491 FMN binding site [chemical binding]; other site 1037911010492 active site 1037911010493 catalytic residues [active] 1037911010494 substrate binding site [chemical binding]; other site 1037911010495 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1037911010496 active site 1037911010497 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911010498 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911010499 Serine hydrolase; Region: Ser_hydrolase; cl17834 1037911010500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911010501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911010502 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1037911010503 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1037911010504 active site 1037911010505 HIGH motif; other site 1037911010506 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1037911010507 active site 1037911010508 KMSKS motif; other site 1037911010509 excinuclease ABC subunit B; Provisional; Region: PRK05298 1037911010510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911010511 ATP binding site [chemical binding]; other site 1037911010512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911010513 nucleotide binding region [chemical binding]; other site 1037911010514 ATP-binding site [chemical binding]; other site 1037911010515 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1037911010516 UvrB/uvrC motif; Region: UVR; pfam02151 1037911010517 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1037911010518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911010519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911010520 homodimer interface [polypeptide binding]; other site 1037911010521 catalytic residue [active] 1037911010522 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911010523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010524 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1037911010525 putative dimerization interface [polypeptide binding]; other site 1037911010526 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1037911010527 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1037911010528 NAD(P) binding site [chemical binding]; other site 1037911010529 catalytic residues [active] 1037911010530 Predicted transcriptional regulators [Transcription]; Region: COG1733 1037911010531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911010532 dimerization interface [polypeptide binding]; other site 1037911010533 putative DNA binding site [nucleotide binding]; other site 1037911010534 putative Zn2+ binding site [ion binding]; other site 1037911010535 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911010536 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1037911010537 putative active site [active] 1037911010538 putative FMN binding site [chemical binding]; other site 1037911010539 putative substrate binding site [chemical binding]; other site 1037911010540 putative catalytic residue [active] 1037911010541 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1037911010542 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1037911010543 active site 1037911010544 Zn binding site [ion binding]; other site 1037911010545 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1037911010546 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1037911010547 active site 1037911010548 substrate binding site [chemical binding]; other site 1037911010549 Mg2+ binding site [ion binding]; other site 1037911010550 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1037911010551 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1037911010552 putative ligand binding residues [chemical binding]; other site 1037911010553 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1037911010554 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1037911010555 ABC-ATPase subunit interface; other site 1037911010556 dimer interface [polypeptide binding]; other site 1037911010557 putative PBP binding regions; other site 1037911010558 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1037911010559 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1037911010560 Walker A/P-loop; other site 1037911010561 ATP binding site [chemical binding]; other site 1037911010562 Q-loop/lid; other site 1037911010563 ABC transporter signature motif; other site 1037911010564 Walker B; other site 1037911010565 D-loop; other site 1037911010566 H-loop/switch region; other site 1037911010567 putative acetyltransferase; Provisional; Region: PRK03624 1037911010568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911010569 Coenzyme A binding pocket [chemical binding]; other site 1037911010570 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1037911010571 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1037911010572 TspO/MBR family; Region: TspO_MBR; pfam03073 1037911010573 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1037911010574 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1037911010575 Chromate transporter; Region: Chromate_transp; pfam02417 1037911010576 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 1037911010577 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1037911010578 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1037911010579 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1037911010580 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1037911010581 G1 box; other site 1037911010582 GTP/Mg2+ binding site [chemical binding]; other site 1037911010583 G2 box; other site 1037911010584 Switch I region; other site 1037911010585 Switch II region; other site 1037911010586 G4 box; other site 1037911010587 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1037911010588 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1037911010589 active site 1037911010590 NTP binding site [chemical binding]; other site 1037911010591 nucleic acid binding site [nucleotide binding]; other site 1037911010592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1037911010593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1037911010594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911010595 Coenzyme A binding pocket [chemical binding]; other site 1037911010596 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1037911010597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1037911010598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911010599 S-adenosylmethionine binding site [chemical binding]; other site 1037911010600 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1037911010601 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911010602 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1037911010603 conserved cys residue [active] 1037911010604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911010605 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1037911010606 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 1037911010607 conserved cys residue [active] 1037911010608 OPT oligopeptide transporter protein; Region: OPT; pfam03169 1037911010609 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911010610 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1037911010611 putative C-terminal domain interface [polypeptide binding]; other site 1037911010612 putative GSH binding site (G-site) [chemical binding]; other site 1037911010613 putative dimer interface [polypeptide binding]; other site 1037911010614 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1037911010615 putative N-terminal domain interface [polypeptide binding]; other site 1037911010616 putative dimer interface [polypeptide binding]; other site 1037911010617 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911010618 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1037911010619 Family of unknown function (DUF633); Region: DUF633; pfam04816 1037911010620 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911010621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911010622 DNA-binding site [nucleotide binding]; DNA binding site 1037911010623 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1037911010624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911010625 D-galactonate transporter; Region: 2A0114; TIGR00893 1037911010626 putative substrate translocation pore; other site 1037911010627 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1037911010628 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1037911010629 active site 1037911010630 tetramer interface [polypeptide binding]; other site 1037911010631 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1037911010632 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1037911010633 putative active site [active] 1037911010634 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1037911010635 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1037911010636 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1037911010637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1037911010638 Transposase; Region: HTH_Tnp_1; pfam01527 1037911010639 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1037911010640 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1037911010641 potential catalytic triad [active] 1037911010642 conserved cys residue [active] 1037911010643 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1037911010644 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1037911010645 DNA binding residues [nucleotide binding] 1037911010646 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1037911010647 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911010648 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911010649 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911010650 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1037911010651 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911010652 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1037911010653 conserved cys residue [active] 1037911010654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911010655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911010656 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911010657 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1037911010658 catalytic triad [active] 1037911010659 conserved cis-peptide bond; other site 1037911010660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911010661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911010662 Coenzyme A binding pocket [chemical binding]; other site 1037911010663 Sulphur transport; Region: Sulf_transp; pfam04143 1037911010664 Sulphur transport; Region: Sulf_transp; pfam04143 1037911010665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911010666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911010667 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1037911010668 CoenzymeA binding site [chemical binding]; other site 1037911010669 subunit interaction site [polypeptide binding]; other site 1037911010670 PHB binding site; other site 1037911010671 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1037911010672 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1037911010673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1037911010674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911010675 dimer interface [polypeptide binding]; other site 1037911010676 phosphorylation site [posttranslational modification] 1037911010677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911010678 ATP binding site [chemical binding]; other site 1037911010679 Mg2+ binding site [ion binding]; other site 1037911010680 G-X-G motif; other site 1037911010681 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911010682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911010683 active site 1037911010684 phosphorylation site [posttranslational modification] 1037911010685 intermolecular recognition site; other site 1037911010686 dimerization interface [polypeptide binding]; other site 1037911010687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911010688 DNA binding site [nucleotide binding] 1037911010689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911010690 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911010691 DNA-binding site [nucleotide binding]; DNA binding site 1037911010692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911010693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911010694 homodimer interface [polypeptide binding]; other site 1037911010695 catalytic residue [active] 1037911010696 benzoate transporter; Region: benE; TIGR00843 1037911010697 Benzoate membrane transport protein; Region: BenE; pfam03594 1037911010698 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1037911010699 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1037911010700 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1037911010701 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911010702 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1037911010703 FMN binding site [chemical binding]; other site 1037911010704 active site 1037911010705 substrate binding site [chemical binding]; other site 1037911010706 catalytic residue [active] 1037911010707 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1037911010708 active site 1 [active] 1037911010709 dimer interface [polypeptide binding]; other site 1037911010710 hexamer interface [polypeptide binding]; other site 1037911010711 active site 2 [active] 1037911010712 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1037911010713 catalytic residues [active] 1037911010714 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1037911010715 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1037911010716 catalytic residues [active] 1037911010717 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1037911010718 classical (c) SDRs; Region: SDR_c; cd05233 1037911010719 NAD(P) binding site [chemical binding]; other site 1037911010720 active site 1037911010721 OsmC-like protein; Region: OsmC; pfam02566 1037911010722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911010723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911010724 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1037911010725 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911010726 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911010727 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1037911010728 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1037911010729 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1037911010730 Trp docking motif [polypeptide binding]; other site 1037911010731 putative active site [active] 1037911010732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911010733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010734 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911010735 putative effector binding pocket; other site 1037911010736 dimerization interface [polypeptide binding]; other site 1037911010737 inner membrane protein; Provisional; Region: PRK10995 1037911010738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911010739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010740 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1037911010741 putative effector binding pocket; other site 1037911010742 putative dimerization interface [polypeptide binding]; other site 1037911010743 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1037911010744 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1037911010745 putative NAD(P) binding site [chemical binding]; other site 1037911010746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911010747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010748 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1037911010749 putative dimerization interface [polypeptide binding]; other site 1037911010750 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1037911010751 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1037911010752 active site 1037911010753 substrate binding site [chemical binding]; other site 1037911010754 FMN binding site [chemical binding]; other site 1037911010755 putative catalytic residues [active] 1037911010756 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911010757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911010758 metal binding site [ion binding]; metal-binding site 1037911010759 active site 1037911010760 I-site; other site 1037911010761 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 1037911010762 PAS domain S-box; Region: sensory_box; TIGR00229 1037911010763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911010764 putative active site [active] 1037911010765 heme pocket [chemical binding]; other site 1037911010766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911010767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911010768 metal binding site [ion binding]; metal-binding site 1037911010769 active site 1037911010770 I-site; other site 1037911010771 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911010772 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1037911010773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1037911010774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911010775 Walker A/P-loop; other site 1037911010776 ATP binding site [chemical binding]; other site 1037911010777 Q-loop/lid; other site 1037911010778 ABC transporter signature motif; other site 1037911010779 Walker B; other site 1037911010780 D-loop; other site 1037911010781 H-loop/switch region; other site 1037911010782 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1037911010783 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1037911010784 catalytic residues [active] 1037911010785 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1037911010786 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1037911010787 active site residue [active] 1037911010788 BolA-like protein; Region: BolA; pfam01722 1037911010789 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1037911010790 fumarate hydratase; Provisional; Region: PRK12425 1037911010791 Class II fumarases; Region: Fumarase_classII; cd01362 1037911010792 active site 1037911010793 tetramer interface [polypeptide binding]; other site 1037911010794 EamA-like transporter family; Region: EamA; pfam00892 1037911010795 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1037911010796 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1037911010797 dimer interface [polypeptide binding]; other site 1037911010798 active site 1037911010799 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1037911010800 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1037911010801 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1037911010802 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1037911010803 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1037911010804 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1037911010805 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1037911010806 active site 1037911010807 dimer interface [polypeptide binding]; other site 1037911010808 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1037911010809 Ligand Binding Site [chemical binding]; other site 1037911010810 Molecular Tunnel; other site 1037911010811 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1037911010812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911010813 Coenzyme A binding pocket [chemical binding]; other site 1037911010814 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1037911010815 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1037911010816 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1037911010817 putative oligomer interface [polypeptide binding]; other site 1037911010818 putative active site [active] 1037911010819 metal binding site [ion binding]; metal-binding site 1037911010820 hypothetical protein; Provisional; Region: PRK00304 1037911010821 Global regulator protein family; Region: CsrA; pfam02599 1037911010822 short chain dehydrogenase; Provisional; Region: PRK05650 1037911010823 classical (c) SDRs; Region: SDR_c; cd05233 1037911010824 NAD(P) binding site [chemical binding]; other site 1037911010825 active site 1037911010826 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1037911010827 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1037911010828 Sulfatase; Region: Sulfatase; pfam00884 1037911010829 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1037911010830 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1037911010831 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1037911010832 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1037911010833 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1037911010834 acyl-activating enzyme (AAE) consensus motif; other site 1037911010835 putative AMP binding site [chemical binding]; other site 1037911010836 putative active site [active] 1037911010837 putative CoA binding site [chemical binding]; other site 1037911010838 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1037911010839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911010840 DNA binding residues [nucleotide binding] 1037911010841 dimerization interface [polypeptide binding]; other site 1037911010842 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1037911010843 Cupin domain; Region: Cupin_2; cl17218 1037911010844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911010845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911010846 putative substrate translocation pore; other site 1037911010847 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1037911010848 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1037911010849 Tetramer interface [polypeptide binding]; other site 1037911010850 active site 1037911010851 FMN-binding site [chemical binding]; other site 1037911010852 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1037911010853 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1037911010854 catalytic site [active] 1037911010855 HemK family putative methylases; Region: hemK_fam; TIGR00536 1037911010856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911010857 S-adenosylmethionine binding site [chemical binding]; other site 1037911010858 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1037911010859 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911010860 catalytic triad [active] 1037911010861 conserved cis-peptide bond; other site 1037911010862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1037911010863 Smr domain; Region: Smr; pfam01713 1037911010864 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1037911010865 homodecamer interface [polypeptide binding]; other site 1037911010866 GTP cyclohydrolase I; Provisional; Region: PLN03044 1037911010867 active site 1037911010868 putative catalytic site residues [active] 1037911010869 zinc binding site [ion binding]; other site 1037911010870 GTP-CH-I/GFRP interaction surface; other site 1037911010871 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911010872 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1037911010873 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1037911010874 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1037911010875 Citrate transporter; Region: CitMHS; pfam03600 1037911010876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911010877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911010878 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1037911010879 putative dimerization interface [polypeptide binding]; other site 1037911010880 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911010881 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1037911010882 putative C-terminal domain interface [polypeptide binding]; other site 1037911010883 putative GSH binding site (G-site) [chemical binding]; other site 1037911010884 putative dimer interface [polypeptide binding]; other site 1037911010885 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1037911010886 N-terminal domain interface [polypeptide binding]; other site 1037911010887 dimer interface [polypeptide binding]; other site 1037911010888 substrate binding pocket (H-site) [chemical binding]; other site 1037911010889 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1037911010890 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1037911010891 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1037911010892 active site 1037911010893 homotetramer interface [polypeptide binding]; other site 1037911010894 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1037911010895 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1037911010896 active site 1037911010897 catalytic site [active] 1037911010898 tetramer interface [polypeptide binding]; other site 1037911010899 OHCU decarboxylase; Region: UHCUDC; TIGR03164 1037911010900 allantoicase; Provisional; Region: PRK13257 1037911010901 Allantoicase repeat; Region: Allantoicase; pfam03561 1037911010902 Allantoicase repeat; Region: Allantoicase; pfam03561 1037911010903 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1037911010904 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1037911010905 Predicted membrane protein [Function unknown]; Region: COG3748 1037911010906 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1037911010907 Cytochrome c; Region: Cytochrom_C; pfam00034 1037911010908 xanthine permease; Region: pbuX; TIGR03173 1037911010909 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1037911010910 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1037911010911 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1037911010912 active site 1037911010913 nucleophile elbow; other site 1037911010914 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1037911010915 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1037911010916 putative acyl-acceptor binding pocket; other site 1037911010917 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1037911010918 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1037911010919 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1037911010920 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1037911010921 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1037911010922 Switch I; other site 1037911010923 Switch II; other site 1037911010924 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1037911010925 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1037911010926 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1037911010927 active site 1037911010928 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1037911010929 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1037911010930 active site 1037911010931 metal binding site [ion binding]; metal-binding site 1037911010932 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1037911010933 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1037911010934 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 1037911010935 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1037911010936 metal binding site [ion binding]; metal-binding site 1037911010937 putative dimer interface [polypeptide binding]; other site 1037911010938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1037911010939 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1037911010940 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911010941 inhibitor-cofactor binding pocket; inhibition site 1037911010942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911010943 catalytic residue [active] 1037911010944 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1037911010945 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1037911010946 amidase catalytic site [active] 1037911010947 Zn binding residues [ion binding]; other site 1037911010948 substrate binding site [chemical binding]; other site 1037911010949 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1037911010950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911010951 dimer interface [polypeptide binding]; other site 1037911010952 phosphorylation site [posttranslational modification] 1037911010953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911010954 ATP binding site [chemical binding]; other site 1037911010955 G-X-G motif; other site 1037911010956 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911010957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911010958 active site 1037911010959 phosphorylation site [posttranslational modification] 1037911010960 intermolecular recognition site; other site 1037911010961 dimerization interface [polypeptide binding]; other site 1037911010962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911010963 DNA binding site [nucleotide binding] 1037911010964 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1037911010965 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1037911010966 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1037911010967 DsbD alpha interface [polypeptide binding]; other site 1037911010968 catalytic residues [active] 1037911010969 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1037911010970 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1037911010971 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1037911010972 catalytic residues [active] 1037911010973 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1037911010974 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1037911010975 dimerization domain [polypeptide binding]; other site 1037911010976 dimer interface [polypeptide binding]; other site 1037911010977 catalytic residues [active] 1037911010978 peptide synthase; Validated; Region: PRK05691 1037911010979 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1037911010980 acyl-activating enzyme (AAE) consensus motif; other site 1037911010981 active site 1037911010982 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911010983 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911010984 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1037911010985 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911010986 acyl-activating enzyme (AAE) consensus motif; other site 1037911010987 AMP binding site [chemical binding]; other site 1037911010988 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911010989 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911010990 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911010991 acyl-activating enzyme (AAE) consensus motif; other site 1037911010992 AMP binding site [chemical binding]; other site 1037911010993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911010994 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1037911010995 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1037911010996 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1037911010997 acyl-activating enzyme (AAE) consensus motif; other site 1037911010998 AMP binding site [chemical binding]; other site 1037911010999 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1037911011000 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1037911011001 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1037911011002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911011003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911011004 DNA binding residues [nucleotide binding] 1037911011005 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1037911011006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911011007 substrate binding pocket [chemical binding]; other site 1037911011008 membrane-bound complex binding site; other site 1037911011009 hinge residues; other site 1037911011010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911011011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911011012 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1037911011013 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1037911011014 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1037911011015 NAD(P) binding site [chemical binding]; other site 1037911011016 substrate binding site [chemical binding]; other site 1037911011017 homotetramer interface [polypeptide binding]; other site 1037911011018 active site 1037911011019 homodimer interface [polypeptide binding]; other site 1037911011020 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1037911011021 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1037911011022 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1037911011023 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911011024 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911011025 active site 1037911011026 enoyl-CoA hydratase; Provisional; Region: PRK05995 1037911011027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911011028 substrate binding site [chemical binding]; other site 1037911011029 oxyanion hole (OAH) forming residues; other site 1037911011030 trimer interface [polypeptide binding]; other site 1037911011031 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1037911011032 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1037911011033 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1037911011034 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1037911011035 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1037911011036 carboxyltransferase (CT) interaction site; other site 1037911011037 biotinylation site [posttranslational modification]; other site 1037911011038 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1037911011039 active site 1037911011040 catalytic site [active] 1037911011041 substrate binding site [chemical binding]; other site 1037911011042 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1037911011043 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1037911011044 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1037911011045 MOSC domain; Region: MOSC; pfam03473 1037911011046 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1037911011047 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911011048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911011049 active site 1037911011050 phosphorylation site [posttranslational modification] 1037911011051 intermolecular recognition site; other site 1037911011052 dimerization interface [polypeptide binding]; other site 1037911011053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1037911011054 Histidine kinase; Region: HisKA_3; pfam07730 1037911011055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911011056 ATP binding site [chemical binding]; other site 1037911011057 Mg2+ binding site [ion binding]; other site 1037911011058 G-X-G motif; other site 1037911011059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911011060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911011061 active site 1037911011062 phosphorylation site [posttranslational modification] 1037911011063 intermolecular recognition site; other site 1037911011064 dimerization interface [polypeptide binding]; other site 1037911011065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911011066 DNA binding residues [nucleotide binding] 1037911011067 dimerization interface [polypeptide binding]; other site 1037911011068 lipid kinase; Reviewed; Region: PRK13054 1037911011069 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1037911011070 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1037911011071 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1037911011072 putative CheA interaction surface; other site 1037911011073 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1037911011074 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1037911011075 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1037911011076 P-loop; other site 1037911011077 Magnesium ion binding site [ion binding]; other site 1037911011078 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1037911011079 Magnesium ion binding site [ion binding]; other site 1037911011080 flagellar motor protein MotD; Reviewed; Region: PRK09038 1037911011081 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1037911011082 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911011083 ligand binding site [chemical binding]; other site 1037911011084 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1037911011085 flagellar motor protein; Reviewed; Region: motC; PRK09109 1037911011086 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1037911011087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911011088 active site 1037911011089 phosphorylation site [posttranslational modification] 1037911011090 intermolecular recognition site; other site 1037911011091 dimerization interface [polypeptide binding]; other site 1037911011092 CheB methylesterase; Region: CheB_methylest; pfam01339 1037911011093 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911011094 putative binding surface; other site 1037911011095 active site 1037911011096 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1037911011097 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1037911011098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911011099 ATP binding site [chemical binding]; other site 1037911011100 Mg2+ binding site [ion binding]; other site 1037911011101 G-X-G motif; other site 1037911011102 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1037911011103 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 1037911011104 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1037911011105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911011106 active site 1037911011107 phosphorylation site [posttranslational modification] 1037911011108 intermolecular recognition site; other site 1037911011109 dimerization interface [polypeptide binding]; other site 1037911011110 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1037911011111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911011112 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1037911011113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911011114 DNA binding residues [nucleotide binding] 1037911011115 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1037911011116 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1037911011117 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1037911011118 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1037911011119 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1037911011120 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1037911011121 FHIPEP family; Region: FHIPEP; pfam00771 1037911011122 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1037911011123 DNA-binding site [nucleotide binding]; DNA binding site 1037911011124 RNA-binding motif; other site 1037911011125 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1037911011126 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1037911011127 RNA binding site [nucleotide binding]; other site 1037911011128 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1037911011129 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1037911011130 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1037911011131 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1037911011132 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1037911011133 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1037911011134 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1037911011135 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1037911011136 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1037911011137 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1037911011138 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 1037911011139 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1037911011140 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911011141 putative binding surface; other site 1037911011142 active site 1037911011143 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911011144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911011145 active site 1037911011146 phosphorylation site [posttranslational modification] 1037911011147 intermolecular recognition site; other site 1037911011148 dimerization interface [polypeptide binding]; other site 1037911011149 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1037911011150 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1037911011151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1037911011152 ATP binding site [chemical binding]; other site 1037911011153 Mg2+ binding site [ion binding]; other site 1037911011154 G-X-G motif; other site 1037911011155 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1037911011156 anti sigma factor interaction site; other site 1037911011157 regulatory phosphorylation site [posttranslational modification]; other site 1037911011158 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1037911011159 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1037911011160 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 1037911011161 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1037911011162 Walker A motif/ATP binding site; other site 1037911011163 Walker B motif; other site 1037911011164 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1037911011165 Flagellar assembly protein FliH; Region: FliH; pfam02108 1037911011166 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1037911011167 MgtE intracellular N domain; Region: MgtE_N; smart00924 1037911011168 FliG C-terminal domain; Region: FliG_C; pfam01706 1037911011169 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1037911011170 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1037911011171 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1037911011172 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1037911011173 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911011174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911011175 active site 1037911011176 phosphorylation site [posttranslational modification] 1037911011177 intermolecular recognition site; other site 1037911011178 dimerization interface [polypeptide binding]; other site 1037911011179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911011180 Walker A motif; other site 1037911011181 ATP binding site [chemical binding]; other site 1037911011182 Walker B motif; other site 1037911011183 arginine finger; other site 1037911011184 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1037911011185 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1037911011186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911011187 putative active site [active] 1037911011188 heme pocket [chemical binding]; other site 1037911011189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911011190 dimer interface [polypeptide binding]; other site 1037911011191 phosphorylation site [posttranslational modification] 1037911011192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911011193 ATP binding site [chemical binding]; other site 1037911011194 Mg2+ binding site [ion binding]; other site 1037911011195 G-X-G motif; other site 1037911011196 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911011197 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1037911011198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911011199 Walker A motif; other site 1037911011200 ATP binding site [chemical binding]; other site 1037911011201 Walker B motif; other site 1037911011202 arginine finger; other site 1037911011203 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911011204 flagellar protein FliS; Validated; Region: fliS; PRK05685 1037911011205 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1037911011206 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1037911011207 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1037911011208 FlaG protein; Region: FlaG; pfam03646 1037911011209 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1037911011210 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1037911011211 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1037911011212 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1037911011213 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1037911011214 dimer interface [polypeptide binding]; other site 1037911011215 active site 1037911011216 CoA binding pocket [chemical binding]; other site 1037911011217 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 1037911011218 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1037911011219 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1037911011220 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 1037911011221 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1037911011222 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1037911011223 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1037911011224 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12713 1037911011225 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1037911011226 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1037911011227 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1037911011228 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1037911011229 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1037911011230 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1037911011231 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1037911011232 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1037911011233 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1037911011234 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1037911011235 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1037911011236 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1037911011237 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1037911011238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911011239 putative active site [active] 1037911011240 heme pocket [chemical binding]; other site 1037911011241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911011242 Walker A motif; other site 1037911011243 ATP binding site [chemical binding]; other site 1037911011244 Walker B motif; other site 1037911011245 arginine finger; other site 1037911011246 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1037911011247 cofactor binding site; other site 1037911011248 metal binding site [ion binding]; metal-binding site 1037911011249 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 1037911011250 aromatic arch; other site 1037911011251 DCoH dimer interaction site [polypeptide binding]; other site 1037911011252 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1037911011253 DCoH tetramer interaction site [polypeptide binding]; other site 1037911011254 substrate binding site [chemical binding]; other site 1037911011255 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1037911011256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911011257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911011258 homodimer interface [polypeptide binding]; other site 1037911011259 catalytic residue [active] 1037911011260 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1037911011261 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1037911011262 putative active site [active] 1037911011263 putative metal binding site [ion binding]; other site 1037911011264 Cupin domain; Region: Cupin_2; cl17218 1037911011265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911011266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911011267 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1037911011268 EamA-like transporter family; Region: EamA; pfam00892 1037911011269 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1037911011270 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1037911011271 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1037911011272 active site 1037911011273 nucleophile elbow; other site 1037911011274 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1037911011275 Surface antigen; Region: Bac_surface_Ag; pfam01103 1037911011276 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1037911011277 MarR family; Region: MarR_2; pfam12802 1037911011278 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1037911011279 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911011280 ATP binding site [chemical binding]; other site 1037911011281 putative Mg++ binding site [ion binding]; other site 1037911011282 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911011283 nucleotide binding region [chemical binding]; other site 1037911011284 ATP-binding site [chemical binding]; other site 1037911011285 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1037911011286 HRDC domain; Region: HRDC; pfam00570 1037911011287 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1037911011288 yecA family protein; Region: ygfB_yecA; TIGR02292 1037911011289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1037911011290 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1037911011291 Na binding site [ion binding]; other site 1037911011292 PAS domain; Region: PAS; smart00091 1037911011293 PAS fold; Region: PAS_7; pfam12860 1037911011294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911011295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911011296 dimer interface [polypeptide binding]; other site 1037911011297 phosphorylation site [posttranslational modification] 1037911011298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911011299 ATP binding site [chemical binding]; other site 1037911011300 Mg2+ binding site [ion binding]; other site 1037911011301 G-X-G motif; other site 1037911011302 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911011303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911011304 active site 1037911011305 phosphorylation site [posttranslational modification] 1037911011306 intermolecular recognition site; other site 1037911011307 dimerization interface [polypeptide binding]; other site 1037911011308 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1037911011309 RmuC family; Region: RmuC; pfam02646 1037911011310 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1037911011311 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1037911011312 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1037911011313 catalytic residues [active] 1037911011314 dimer interface [polypeptide binding]; other site 1037911011315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911011316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911011317 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1037911011318 MarR family; Region: MarR_2; pfam12802 1037911011319 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1037911011320 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1037911011321 catalytic core [active] 1037911011322 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1037911011323 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1037911011324 putative dimer interface [polypeptide binding]; other site 1037911011325 active site pocket [active] 1037911011326 putative cataytic base [active] 1037911011327 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1037911011328 homotrimer interface [polypeptide binding]; other site 1037911011329 Walker A motif; other site 1037911011330 GTP binding site [chemical binding]; other site 1037911011331 Walker B motif; other site 1037911011332 cobyric acid synthase; Provisional; Region: PRK00784 1037911011333 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1037911011334 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1037911011335 catalytic triad [active] 1037911011336 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1037911011337 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911011338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911011339 homodimer interface [polypeptide binding]; other site 1037911011340 catalytic residue [active] 1037911011341 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1037911011342 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1037911011343 FMN binding site [chemical binding]; other site 1037911011344 dimer interface [polypeptide binding]; other site 1037911011345 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1037911011346 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1037911011347 catalytic triad [active] 1037911011348 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1037911011349 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1037911011350 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1037911011351 Walker A motif; other site 1037911011352 homodimer interface [polypeptide binding]; other site 1037911011353 ATP binding site [chemical binding]; other site 1037911011354 hydroxycobalamin binding site [chemical binding]; other site 1037911011355 Walker B motif; other site 1037911011356 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1037911011357 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1037911011358 NlpC/P60 family; Region: NLPC_P60; pfam00877 1037911011359 NlpC/P60 family; Region: NLPC_P60; pfam00877 1037911011360 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1037911011361 DNA replication initiation factor; Validated; Region: PRK05642 1037911011362 Walker A motif; other site 1037911011363 ATP binding site [chemical binding]; other site 1037911011364 Walker B motif; other site 1037911011365 arginine finger; other site 1037911011366 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1037911011367 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1037911011368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 1037911011369 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1037911011370 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1037911011371 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1037911011372 dimerization interface [polypeptide binding]; other site 1037911011373 putative ATP binding site [chemical binding]; other site 1037911011374 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1037911011375 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1037911011376 active site 1037911011377 substrate binding site [chemical binding]; other site 1037911011378 cosubstrate binding site; other site 1037911011379 catalytic site [active] 1037911011380 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1037911011381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911011382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911011383 putative substrate translocation pore; other site 1037911011384 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911011385 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911011386 N-terminal plug; other site 1037911011387 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1037911011388 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1037911011389 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1037911011390 homodimer interface [polypeptide binding]; other site 1037911011391 metal binding site [ion binding]; metal-binding site 1037911011392 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1037911011393 homodimer interface [polypeptide binding]; other site 1037911011394 active site 1037911011395 putative chemical substrate binding site [chemical binding]; other site 1037911011396 metal binding site [ion binding]; metal-binding site 1037911011397 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1037911011398 HD domain; Region: HD_4; pfam13328 1037911011399 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1037911011400 synthetase active site [active] 1037911011401 NTP binding site [chemical binding]; other site 1037911011402 metal binding site [ion binding]; metal-binding site 1037911011403 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1037911011404 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1037911011405 active site 1037911011406 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1037911011407 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1037911011408 TRAM domain; Region: TRAM; pfam01938 1037911011409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911011410 S-adenosylmethionine binding site [chemical binding]; other site 1037911011411 cysteine synthase B; Region: cysM; TIGR01138 1037911011412 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1037911011413 dimer interface [polypeptide binding]; other site 1037911011414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911011415 catalytic residue [active] 1037911011416 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1037911011417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911011418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911011419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911011420 dimerization interface [polypeptide binding]; other site 1037911011421 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1037911011422 agmatinase; Region: agmatinase; TIGR01230 1037911011423 oligomer interface [polypeptide binding]; other site 1037911011424 putative active site [active] 1037911011425 Mn binding site [ion binding]; other site 1037911011426 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1037911011427 Na binding site [ion binding]; other site 1037911011428 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911011429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911011430 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1037911011431 putative dimerization interface [polypeptide binding]; other site 1037911011432 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1037911011433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911011434 putative substrate translocation pore; other site 1037911011435 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1037911011436 S1 domain; Region: S1_2; pfam13509 1037911011437 S1 domain; Region: S1_2; pfam13509 1037911011438 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1037911011439 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1037911011440 Copper resistance protein D; Region: CopD; pfam05425 1037911011441 CopC domain; Region: CopC; pfam04234 1037911011442 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1037911011443 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1037911011444 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1037911011445 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1037911011446 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1037911011447 helicase 45; Provisional; Region: PTZ00424 1037911011448 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1037911011449 ATP binding site [chemical binding]; other site 1037911011450 Mg++ binding site [ion binding]; other site 1037911011451 motif III; other site 1037911011452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911011453 nucleotide binding region [chemical binding]; other site 1037911011454 ATP-binding site [chemical binding]; other site 1037911011455 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1037911011456 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1037911011457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911011458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911011459 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1037911011460 classical (c) SDRs; Region: SDR_c; cd05233 1037911011461 NAD(P) binding site [chemical binding]; other site 1037911011462 active site 1037911011463 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1037911011464 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1037911011465 putative NAD(P) binding site [chemical binding]; other site 1037911011466 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1037911011467 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1037911011468 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1037911011469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911011470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911011471 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1037911011472 dimerization interface [polypeptide binding]; other site 1037911011473 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1037911011474 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911011475 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1037911011476 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1037911011477 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1037911011478 substrate binding site [chemical binding]; other site 1037911011479 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1037911011480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1037911011481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911011482 Walker A/P-loop; other site 1037911011483 ATP binding site [chemical binding]; other site 1037911011484 Q-loop/lid; other site 1037911011485 ABC transporter signature motif; other site 1037911011486 Walker B; other site 1037911011487 D-loop; other site 1037911011488 H-loop/switch region; other site 1037911011489 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1037911011490 amphipathic channel; other site 1037911011491 Asn-Pro-Ala signature motifs; other site 1037911011492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1037911011493 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1037911011494 Putative zinc-finger; Region: zf-HC2; pfam13490 1037911011495 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1037911011496 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911011497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1037911011498 DNA binding residues [nucleotide binding] 1037911011499 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1037911011500 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1037911011501 dimer interface [polypeptide binding]; other site 1037911011502 active site 1037911011503 CoA binding pocket [chemical binding]; other site 1037911011504 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1037911011505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911011506 ATP binding site [chemical binding]; other site 1037911011507 putative Mg++ binding site [ion binding]; other site 1037911011508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911011509 nucleotide binding region [chemical binding]; other site 1037911011510 ATP-binding site [chemical binding]; other site 1037911011511 Helicase associated domain (HA2); Region: HA2; pfam04408 1037911011512 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1037911011513 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1037911011514 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1037911011515 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1037911011516 EamA-like transporter family; Region: EamA; pfam00892 1037911011517 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1037911011518 EamA-like transporter family; Region: EamA; pfam00892 1037911011519 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1037911011520 EamA-like transporter family; Region: EamA; pfam00892 1037911011521 CAAX protease self-immunity; Region: Abi; pfam02517 1037911011522 PAS domain; Region: PAS_9; pfam13426 1037911011523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911011524 putative active site [active] 1037911011525 heme pocket [chemical binding]; other site 1037911011526 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911011527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911011528 dimer interface [polypeptide binding]; other site 1037911011529 putative CheW interface [polypeptide binding]; other site 1037911011530 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1037911011531 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1037911011532 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1037911011533 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1037911011534 Low-spin heme binding site [chemical binding]; other site 1037911011535 Putative water exit pathway; other site 1037911011536 Binuclear center (active site) [active] 1037911011537 Putative proton exit pathway; other site 1037911011538 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1037911011539 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1037911011540 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1037911011541 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1037911011542 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1037911011543 Cytochrome c; Region: Cytochrom_C; cl11414 1037911011544 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1037911011545 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1037911011546 Low-spin heme binding site [chemical binding]; other site 1037911011547 Putative water exit pathway; other site 1037911011548 Binuclear center (active site) [active] 1037911011549 Putative proton exit pathway; other site 1037911011550 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1037911011551 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1037911011552 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1037911011553 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1037911011554 Cytochrome c; Region: Cytochrom_C; pfam00034 1037911011555 Cytochrome c; Region: Cytochrom_C; pfam00034 1037911011556 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1037911011557 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1037911011558 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1037911011559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1037911011560 FixH; Region: FixH; pfam05751 1037911011561 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1037911011562 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1037911011563 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1037911011564 metal-binding site [ion binding] 1037911011565 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1037911011566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911011567 motif II; other site 1037911011568 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 1037911011569 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1037911011570 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1037911011571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911011572 FeS/SAM binding site; other site 1037911011573 HemN C-terminal domain; Region: HemN_C; pfam06969 1037911011574 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1037911011575 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1037911011576 ligand binding site [chemical binding]; other site 1037911011577 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1037911011578 putative switch regulator; other site 1037911011579 non-specific DNA interactions [nucleotide binding]; other site 1037911011580 DNA binding site [nucleotide binding] 1037911011581 sequence specific DNA binding site [nucleotide binding]; other site 1037911011582 putative cAMP binding site [chemical binding]; other site 1037911011583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911011584 active site 1037911011585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1037911011586 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911011587 active site 1037911011588 recombination protein RecR; Reviewed; Region: recR; PRK00076 1037911011589 RecR protein; Region: RecR; pfam02132 1037911011590 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1037911011591 putative active site [active] 1037911011592 putative metal-binding site [ion binding]; other site 1037911011593 tetramer interface [polypeptide binding]; other site 1037911011594 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1037911011595 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1037911011596 NAD(P) binding site [chemical binding]; other site 1037911011597 substrate binding site [chemical binding]; other site 1037911011598 dimer interface [polypeptide binding]; other site 1037911011599 hypothetical protein; Validated; Region: PRK00153 1037911011600 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1037911011601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911011602 Walker A motif; other site 1037911011603 ATP binding site [chemical binding]; other site 1037911011604 Walker B motif; other site 1037911011605 arginine finger; other site 1037911011606 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1037911011607 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1037911011608 EamA-like transporter family; Region: EamA; pfam00892 1037911011609 EamA-like transporter family; Region: EamA; pfam00892 1037911011610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911011611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911011612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911011613 dimerization interface [polypeptide binding]; other site 1037911011614 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 1037911011615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1037911011616 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1037911011617 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1037911011618 Ligase N family; Region: LIGANc; smart00532 1037911011619 nucleotide binding pocket [chemical binding]; other site 1037911011620 K-X-D-G motif; other site 1037911011621 catalytic site [active] 1037911011622 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1037911011623 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1037911011624 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1037911011625 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1037911011626 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1037911011627 DNA binding site [nucleotide binding] 1037911011628 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1037911011629 Dimer interface [polypeptide binding]; other site 1037911011630 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 1037911011631 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 1037911011632 FtsZ protein binding site [polypeptide binding]; other site 1037911011633 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1037911011634 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1037911011635 Walker A/P-loop; other site 1037911011636 ATP binding site [chemical binding]; other site 1037911011637 Q-loop/lid; other site 1037911011638 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1037911011639 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1037911011640 ABC transporter signature motif; other site 1037911011641 Walker B; other site 1037911011642 D-loop; other site 1037911011643 H-loop/switch region; other site 1037911011644 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1037911011645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911011646 DNA-binding site [nucleotide binding]; DNA binding site 1037911011647 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1037911011648 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911011649 catalytic loop [active] 1037911011650 iron binding site [ion binding]; other site 1037911011651 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1037911011652 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1037911011653 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1037911011654 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1037911011655 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1037911011656 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1037911011657 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1037911011658 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1037911011659 guanine deaminase; Provisional; Region: PRK09228 1037911011660 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1037911011661 active site 1037911011662 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1037911011663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911011664 DNA-binding site [nucleotide binding]; DNA binding site 1037911011665 FCD domain; Region: FCD; pfam07729 1037911011666 benzoate transporter; Region: benE; TIGR00843 1037911011667 Benzoate membrane transport protein; Region: BenE; pfam03594 1037911011668 Protein with unknown function (DUF469); Region: DUF469; cl01237 1037911011669 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1037911011670 CHASE domain; Region: CHASE; pfam03924 1037911011671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911011672 PAS domain; Region: PAS_9; pfam13426 1037911011673 putative active site [active] 1037911011674 heme pocket [chemical binding]; other site 1037911011675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911011676 putative active site [active] 1037911011677 heme pocket [chemical binding]; other site 1037911011678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911011679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911011680 metal binding site [ion binding]; metal-binding site 1037911011681 active site 1037911011682 I-site; other site 1037911011683 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1037911011684 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1037911011685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1037911011686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911011687 S-adenosylmethionine binding site [chemical binding]; other site 1037911011688 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1037911011689 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1037911011690 quinone interaction residues [chemical binding]; other site 1037911011691 active site 1037911011692 catalytic residues [active] 1037911011693 FMN binding site [chemical binding]; other site 1037911011694 substrate binding site [chemical binding]; other site 1037911011695 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1037911011696 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1037911011697 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1037911011698 catalytic residue [active] 1037911011699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911011700 DNA binding site [nucleotide binding] 1037911011701 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1037911011702 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1037911011703 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1037911011704 NMT1-like family; Region: NMT1_2; pfam13379 1037911011705 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1037911011706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911011707 active site 1037911011708 phosphorylation site [posttranslational modification] 1037911011709 intermolecular recognition site; other site 1037911011710 dimerization interface [polypeptide binding]; other site 1037911011711 ANTAR domain; Region: ANTAR; pfam03861 1037911011712 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1037911011713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911011714 putative substrate translocation pore; other site 1037911011715 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1037911011716 active site 1037911011717 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1037911011718 active site 1037911011719 ATP binding site [chemical binding]; other site 1037911011720 substrate binding site [chemical binding]; other site 1037911011721 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1037911011722 activation loop (A-loop); other site 1037911011723 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1037911011724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911011725 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1037911011726 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1037911011727 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1037911011728 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1037911011729 [2Fe-2S] cluster binding site [ion binding]; other site 1037911011730 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1037911011731 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1037911011732 [4Fe-4S] binding site [ion binding]; other site 1037911011733 molybdopterin cofactor binding site; other site 1037911011734 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1037911011735 molybdopterin cofactor binding site; other site 1037911011736 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1037911011737 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1037911011738 active site 1037911011739 SAM binding site [chemical binding]; other site 1037911011740 homodimer interface [polypeptide binding]; other site 1037911011741 OprF membrane domain; Region: OprF; pfam05736 1037911011742 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911011743 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1037911011744 ligand binding site [chemical binding]; other site 1037911011745 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 1037911011746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911011747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911011748 DNA binding residues [nucleotide binding] 1037911011749 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1037911011750 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1037911011751 Cl binding site [ion binding]; other site 1037911011752 oligomer interface [polypeptide binding]; other site 1037911011753 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1037911011754 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911011755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911011756 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1037911011757 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1037911011758 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1037911011759 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1037911011760 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1037911011761 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911011762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911011763 DNA-binding site [nucleotide binding]; DNA binding site 1037911011764 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911011765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911011766 homodimer interface [polypeptide binding]; other site 1037911011767 catalytic residue [active] 1037911011768 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1037911011769 EamA-like transporter family; Region: EamA; pfam00892 1037911011770 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1037911011771 MPN+ (JAMM) motif; other site 1037911011772 Zinc-binding site [ion binding]; other site 1037911011773 hypothetical protein; Validated; Region: PRK07411 1037911011774 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1037911011775 ATP binding site [chemical binding]; other site 1037911011776 substrate interface [chemical binding]; other site 1037911011777 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1037911011778 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1037911011779 active site residue [active] 1037911011780 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1037911011781 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1037911011782 dimer interface [polypeptide binding]; other site 1037911011783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911011784 catalytic residue [active] 1037911011785 serine O-acetyltransferase; Region: cysE; TIGR01172 1037911011786 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1037911011787 trimer interface [polypeptide binding]; other site 1037911011788 active site 1037911011789 substrate binding site [chemical binding]; other site 1037911011790 CoA binding site [chemical binding]; other site 1037911011791 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1037911011792 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1037911011793 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1037911011794 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1037911011795 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1037911011796 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1037911011797 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1037911011798 substrate binding site [chemical binding]; other site 1037911011799 ligand binding site [chemical binding]; other site 1037911011800 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1037911011801 substrate binding site [chemical binding]; other site 1037911011802 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1037911011803 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1037911011804 dimer interface [polypeptide binding]; other site 1037911011805 active site 1037911011806 citrylCoA binding site [chemical binding]; other site 1037911011807 oxalacetate/citrate binding site [chemical binding]; other site 1037911011808 coenzyme A binding site [chemical binding]; other site 1037911011809 catalytic triad [active] 1037911011810 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1037911011811 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1037911011812 tetramer interface [polypeptide binding]; other site 1037911011813 active site 1037911011814 Mg2+/Mn2+ binding site [ion binding]; other site 1037911011815 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1037911011816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911011817 DNA-binding site [nucleotide binding]; DNA binding site 1037911011818 FCD domain; Region: FCD; pfam07729 1037911011819 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1037911011820 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1037911011821 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1037911011822 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1037911011823 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1037911011824 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1037911011825 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1037911011826 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1037911011827 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 1037911011828 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1037911011829 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1037911011830 Active Sites [active] 1037911011831 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1037911011832 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1037911011833 Na binding site [ion binding]; other site 1037911011834 putative substrate binding site [chemical binding]; other site 1037911011835 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1037911011836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911011837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911011838 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1037911011839 putative effector binding pocket; other site 1037911011840 dimerization interface [polypeptide binding]; other site 1037911011841 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1037911011842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911011843 NAD(P) binding site [chemical binding]; other site 1037911011844 active site 1037911011845 hydrolase; Region: PLN02811 1037911011846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911011847 motif II; other site 1037911011848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911011849 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1037911011850 non-specific DNA binding site [nucleotide binding]; other site 1037911011851 salt bridge; other site 1037911011852 sequence-specific DNA binding site [nucleotide binding]; other site 1037911011853 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1037911011854 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 1037911011855 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1037911011856 putative NAD(P) binding site [chemical binding]; other site 1037911011857 putative active site [active] 1037911011858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911011859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911011860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911011861 dimerization interface [polypeptide binding]; other site 1037911011862 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 1037911011863 EamA-like transporter family; Region: EamA; pfam00892 1037911011864 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1037911011865 EamA-like transporter family; Region: EamA; pfam00892 1037911011866 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1037911011867 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1037911011868 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911011869 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1037911011870 substrate binding site [chemical binding]; other site 1037911011871 oxyanion hole (OAH) forming residues; other site 1037911011872 trimer interface [polypeptide binding]; other site 1037911011873 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1037911011874 putative acyl-acceptor binding pocket; other site 1037911011875 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1037911011876 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1037911011877 oligomer interface [polypeptide binding]; other site 1037911011878 metal binding site [ion binding]; metal-binding site 1037911011879 metal binding site [ion binding]; metal-binding site 1037911011880 putative Cl binding site [ion binding]; other site 1037911011881 basic sphincter; other site 1037911011882 hydrophobic gate; other site 1037911011883 periplasmic entrance; other site 1037911011884 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1037911011885 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1037911011886 catalytic triad [active] 1037911011887 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1037911011888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1037911011889 substrate binding site [chemical binding]; other site 1037911011890 oxyanion hole (OAH) forming residues; other site 1037911011891 trimer interface [polypeptide binding]; other site 1037911011892 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1037911011893 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1037911011894 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1037911011895 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1037911011896 dimer interface [polypeptide binding]; other site 1037911011897 active site 1037911011898 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911011899 Cytochrome c; Region: Cytochrom_C; pfam00034 1037911011900 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1037911011901 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1037911011902 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1037911011903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1037911011904 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1037911011905 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1037911011906 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1037911011907 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1037911011908 putative lipid binding site [chemical binding]; other site 1037911011909 Flagellin N-methylase; Region: FliB; cl00497 1037911011910 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911011911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911011912 DNA-binding site [nucleotide binding]; DNA binding site 1037911011913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911011914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911011915 homodimer interface [polypeptide binding]; other site 1037911011916 catalytic residue [active] 1037911011917 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1037911011918 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911011919 ligand binding site [chemical binding]; other site 1037911011920 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1037911011921 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911011922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911011923 substrate binding pocket [chemical binding]; other site 1037911011924 membrane-bound complex binding site; other site 1037911011925 hinge residues; other site 1037911011926 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1037911011927 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1037911011928 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1037911011929 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1037911011930 Ligand binding site [chemical binding]; other site 1037911011931 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1037911011932 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1037911011933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911011934 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1037911011935 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1037911011936 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911011937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911011938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911011939 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1037911011940 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1037911011941 putative NAD(P) binding site [chemical binding]; other site 1037911011942 putative substrate binding site [chemical binding]; other site 1037911011943 catalytic Zn binding site [ion binding]; other site 1037911011944 structural Zn binding site [ion binding]; other site 1037911011945 dimer interface [polypeptide binding]; other site 1037911011946 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1037911011947 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1037911011948 Bacterial transcriptional regulator; Region: IclR; pfam01614 1037911011949 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1037911011950 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1037911011951 TM-ABC transporter signature motif; other site 1037911011952 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1037911011953 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1037911011954 Walker A/P-loop; other site 1037911011955 ATP binding site [chemical binding]; other site 1037911011956 Q-loop/lid; other site 1037911011957 ABC transporter signature motif; other site 1037911011958 Walker B; other site 1037911011959 D-loop; other site 1037911011960 H-loop/switch region; other site 1037911011961 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1037911011962 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1037911011963 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1037911011964 ligand binding site [chemical binding]; other site 1037911011965 short chain dehydrogenase; Provisional; Region: PRK07063 1037911011966 classical (c) SDRs; Region: SDR_c; cd05233 1037911011967 NAD(P) binding site [chemical binding]; other site 1037911011968 active site 1037911011969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1037911011970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911011971 Coenzyme A binding pocket [chemical binding]; other site 1037911011972 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1037911011973 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1037911011974 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1037911011975 substrate binding site [chemical binding]; other site 1037911011976 ATP binding site [chemical binding]; other site 1037911011977 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1037911011978 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1037911011979 Na binding site [ion binding]; other site 1037911011980 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1037911011981 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1037911011982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911011983 DNA-binding site [nucleotide binding]; DNA binding site 1037911011984 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1037911011985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1037911011986 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1037911011987 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1037911011988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911011989 FeS/SAM binding site; other site 1037911011990 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1037911011991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911011992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911011993 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1037911011994 active site 1037911011995 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1037911011996 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1037911011997 thymidylate kinase; Validated; Region: tmk; PRK00698 1037911011998 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1037911011999 TMP-binding site; other site 1037911012000 ATP-binding site [chemical binding]; other site 1037911012001 YceG-like family; Region: YceG; pfam02618 1037911012002 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1037911012003 dimerization interface [polypeptide binding]; other site 1037911012004 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1037911012005 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1037911012006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911012007 catalytic residue [active] 1037911012008 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1037911012009 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1037911012010 dimer interface [polypeptide binding]; other site 1037911012011 active site 1037911012012 acyl carrier protein; Provisional; Region: acpP; PRK00982 1037911012013 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1037911012014 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1037911012015 NAD(P) binding site [chemical binding]; other site 1037911012016 homotetramer interface [polypeptide binding]; other site 1037911012017 homodimer interface [polypeptide binding]; other site 1037911012018 active site 1037911012019 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1037911012020 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1037911012021 putative phosphate acyltransferase; Provisional; Region: PRK05331 1037911012022 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1037911012023 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1037911012024 Maf-like protein; Region: Maf; pfam02545 1037911012025 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1037911012026 active site 1037911012027 dimer interface [polypeptide binding]; other site 1037911012028 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1037911012029 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1037911012030 tandem repeat interface [polypeptide binding]; other site 1037911012031 oligomer interface [polypeptide binding]; other site 1037911012032 active site residues [active] 1037911012033 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1037911012034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911012035 motif II; other site 1037911012036 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1037911012037 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1037911012038 RNA binding surface [nucleotide binding]; other site 1037911012039 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1037911012040 active site 1037911012041 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1037911012042 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1037911012043 homodimer interface [polypeptide binding]; other site 1037911012044 oligonucleotide binding site [chemical binding]; other site 1037911012045 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1037911012046 Ligand binding site; other site 1037911012047 metal-binding site 1037911012048 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1037911012049 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1037911012050 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1037911012051 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1037911012052 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1037911012053 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1037911012054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911012055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911012056 sensor protein PhoQ; Provisional; Region: PRK10815 1037911012057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911012058 ATP binding site [chemical binding]; other site 1037911012059 Mg2+ binding site [ion binding]; other site 1037911012060 G-X-G motif; other site 1037911012061 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1037911012062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012063 active site 1037911012064 phosphorylation site [posttranslational modification] 1037911012065 intermolecular recognition site; other site 1037911012066 dimerization interface [polypeptide binding]; other site 1037911012067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911012068 DNA binding site [nucleotide binding] 1037911012069 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1037911012070 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1037911012071 sensor protein RstB; Provisional; Region: PRK10604 1037911012072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911012073 dimerization interface [polypeptide binding]; other site 1037911012074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911012075 dimer interface [polypeptide binding]; other site 1037911012076 phosphorylation site [posttranslational modification] 1037911012077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911012078 ATP binding site [chemical binding]; other site 1037911012079 Mg2+ binding site [ion binding]; other site 1037911012080 G-X-G motif; other site 1037911012081 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1037911012082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012083 active site 1037911012084 phosphorylation site [posttranslational modification] 1037911012085 intermolecular recognition site; other site 1037911012086 dimerization interface [polypeptide binding]; other site 1037911012087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911012088 DNA binding site [nucleotide binding] 1037911012089 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1037911012090 ATP cone domain; Region: ATP-cone; pfam03477 1037911012091 ATP cone domain; Region: ATP-cone; pfam03477 1037911012092 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1037911012093 active site 1037911012094 dimer interface [polypeptide binding]; other site 1037911012095 catalytic residues [active] 1037911012096 effector binding site; other site 1037911012097 R2 peptide binding site; other site 1037911012098 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1037911012099 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1037911012100 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1037911012101 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1037911012102 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1037911012103 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1037911012104 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1037911012105 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1037911012106 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1037911012107 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1037911012108 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1037911012109 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1037911012110 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1037911012111 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1037911012112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911012113 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1037911012114 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911012115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012116 active site 1037911012117 phosphorylation site [posttranslational modification] 1037911012118 intermolecular recognition site; other site 1037911012119 dimerization interface [polypeptide binding]; other site 1037911012120 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1037911012121 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1037911012122 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1037911012123 FlgN protein; Region: FlgN; pfam05130 1037911012124 Flagellar regulator YcgR; Region: YcgR; pfam07317 1037911012125 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1037911012126 PilZ domain; Region: PilZ; pfam07238 1037911012127 putative MFS family transporter protein; Provisional; Region: PRK03633 1037911012128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911012129 putative substrate translocation pore; other site 1037911012130 Arc-like DNA binding domain; Region: Arc; pfam03869 1037911012131 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1037911012132 MgtE intracellular N domain; Region: MgtE_N; smart00924 1037911012133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1037911012134 Divalent cation transporter; Region: MgtE; pfam01769 1037911012135 carbon storage regulator; Provisional; Region: PRK01712 1037911012136 aspartate kinase; Reviewed; Region: PRK06635 1037911012137 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1037911012138 putative nucleotide binding site [chemical binding]; other site 1037911012139 putative catalytic residues [active] 1037911012140 putative Mg ion binding site [ion binding]; other site 1037911012141 putative aspartate binding site [chemical binding]; other site 1037911012142 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1037911012143 putative allosteric regulatory site; other site 1037911012144 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1037911012145 putative allosteric regulatory residue; other site 1037911012146 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1037911012147 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1037911012148 motif 1; other site 1037911012149 active site 1037911012150 motif 2; other site 1037911012151 motif 3; other site 1037911012152 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1037911012153 DHHA1 domain; Region: DHHA1; pfam02272 1037911012154 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1037911012155 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1037911012156 tetramer interface [polypeptide binding]; other site 1037911012157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911012158 catalytic residue [active] 1037911012159 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 1037911012160 active site 1037911012161 homopentamer interface [polypeptide binding]; other site 1037911012162 dimer interface [polypeptide binding]; other site 1037911012163 succinylglutamate desuccinylase; Provisional; Region: PRK05324 1037911012164 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1037911012165 active site 1037911012166 Zn binding site [ion binding]; other site 1037911012167 succinylarginine dihydrolase; Provisional; Region: PRK13281 1037911012168 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1037911012169 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1037911012170 NAD(P) binding site [chemical binding]; other site 1037911012171 catalytic residues [active] 1037911012172 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1037911012173 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 1037911012174 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1037911012175 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1037911012176 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1037911012177 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911012178 inhibitor-cofactor binding pocket; inhibition site 1037911012179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911012180 catalytic residue [active] 1037911012181 Leucine rich repeat; Region: LRR_8; pfam13855 1037911012182 Leucine rich repeat; Region: LRR_8; pfam13855 1037911012183 Leucine rich repeat; Region: LRR_8; pfam13855 1037911012184 Leucine rich repeat; Region: LRR_8; pfam13855 1037911012185 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911012186 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1037911012187 conserved cys residue [active] 1037911012188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911012189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911012190 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1037911012191 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911012192 Walker A/P-loop; other site 1037911012193 ATP binding site [chemical binding]; other site 1037911012194 Q-loop/lid; other site 1037911012195 ABC transporter signature motif; other site 1037911012196 Walker B; other site 1037911012197 D-loop; other site 1037911012198 H-loop/switch region; other site 1037911012199 Predicted deacylase [General function prediction only]; Region: COG3608 1037911012200 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1037911012201 active site 1037911012202 Zn binding site [ion binding]; other site 1037911012203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911012204 dimer interface [polypeptide binding]; other site 1037911012205 conserved gate region; other site 1037911012206 putative PBP binding loops; other site 1037911012207 ABC-ATPase subunit interface; other site 1037911012208 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911012209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911012210 dimer interface [polypeptide binding]; other site 1037911012211 conserved gate region; other site 1037911012212 putative PBP binding loops; other site 1037911012213 ABC-ATPase subunit interface; other site 1037911012214 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1037911012215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911012216 substrate binding pocket [chemical binding]; other site 1037911012217 membrane-bound complex binding site; other site 1037911012218 hinge residues; other site 1037911012219 acetyl-CoA synthetase; Provisional; Region: PRK00174 1037911012220 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1037911012221 active site 1037911012222 CoA binding site [chemical binding]; other site 1037911012223 acyl-activating enzyme (AAE) consensus motif; other site 1037911012224 AMP binding site [chemical binding]; other site 1037911012225 acetate binding site [chemical binding]; other site 1037911012226 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1037911012227 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1037911012228 oligomeric interface; other site 1037911012229 putative active site [active] 1037911012230 homodimer interface [polypeptide binding]; other site 1037911012231 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1037911012232 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1037911012233 dimer interface [polypeptide binding]; other site 1037911012234 putative radical transfer pathway; other site 1037911012235 diiron center [ion binding]; other site 1037911012236 tyrosyl radical; other site 1037911012237 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1037911012238 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1037911012239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911012240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911012241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911012242 dimerization interface [polypeptide binding]; other site 1037911012243 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911012244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911012245 dimer interface [polypeptide binding]; other site 1037911012246 conserved gate region; other site 1037911012247 putative PBP binding loops; other site 1037911012248 ABC-ATPase subunit interface; other site 1037911012249 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1037911012250 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911012251 Walker A/P-loop; other site 1037911012252 ATP binding site [chemical binding]; other site 1037911012253 Q-loop/lid; other site 1037911012254 ABC transporter signature motif; other site 1037911012255 Walker B; other site 1037911012256 D-loop; other site 1037911012257 H-loop/switch region; other site 1037911012258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911012259 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911012260 substrate binding pocket [chemical binding]; other site 1037911012261 membrane-bound complex binding site; other site 1037911012262 hinge residues; other site 1037911012263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911012264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911012265 putative substrate translocation pore; other site 1037911012266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1037911012267 salt bridge; other site 1037911012268 sequence-specific DNA binding site [nucleotide binding]; other site 1037911012269 amidase; Provisional; Region: PRK08137 1037911012270 Amidase; Region: Amidase; cl11426 1037911012271 Amidase; Region: Amidase; cl11426 1037911012272 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1037911012273 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1037911012274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911012275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911012276 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1037911012277 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1037911012278 MASE2 domain; Region: MASE2; pfam05230 1037911012279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911012280 metal binding site [ion binding]; metal-binding site 1037911012281 active site 1037911012282 I-site; other site 1037911012283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911012284 PAS domain; Region: PAS_9; pfam13426 1037911012285 putative active site [active] 1037911012286 heme pocket [chemical binding]; other site 1037911012287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911012288 PAS domain; Region: PAS_9; pfam13426 1037911012289 putative active site [active] 1037911012290 heme pocket [chemical binding]; other site 1037911012291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911012292 dimer interface [polypeptide binding]; other site 1037911012293 putative CheW interface [polypeptide binding]; other site 1037911012294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911012295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911012296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911012297 dimerization interface [polypeptide binding]; other site 1037911012298 hypothetical protein; Validated; Region: PRK06186 1037911012299 conserved cys residue [active] 1037911012300 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1037911012301 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 1037911012302 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1037911012303 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1037911012304 active site 1037911012305 catalytic site [active] 1037911012306 Predicted membrane protein [Function unknown]; Region: COG3212 1037911012307 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1037911012308 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1037911012309 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1037911012310 Cl binding site [ion binding]; other site 1037911012311 oligomer interface [polypeptide binding]; other site 1037911012312 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1037911012313 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1037911012314 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1037911012315 hypothetical protein; Provisional; Region: PRK12569 1037911012316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911012317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911012318 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1037911012319 putative substrate binding pocket [chemical binding]; other site 1037911012320 dimerization interface [polypeptide binding]; other site 1037911012321 transcriptional regulator; Provisional; Region: PRK10632 1037911012322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911012323 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1037911012324 putative effector binding pocket; other site 1037911012325 putative dimerization interface [polypeptide binding]; other site 1037911012326 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1037911012327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911012328 NAD(P) binding site [chemical binding]; other site 1037911012329 active site 1037911012330 Predicted membrane protein [Function unknown]; Region: COG4125 1037911012331 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1037911012332 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1037911012333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911012334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911012335 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911012336 dimerization interface [polypeptide binding]; other site 1037911012337 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1037911012338 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911012339 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1037911012340 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1037911012341 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1037911012342 putative hydrophobic ligand binding site [chemical binding]; other site 1037911012343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1037911012344 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1037911012345 SnoaL-like domain; Region: SnoaL_3; pfam13474 1037911012346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911012347 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1037911012348 Coenzyme A binding pocket [chemical binding]; other site 1037911012349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1037911012350 aminotransferase; Validated; Region: PRK08175 1037911012351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911012352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911012353 homodimer interface [polypeptide binding]; other site 1037911012354 catalytic residue [active] 1037911012355 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1037911012356 GntP family permease; Region: GntP_permease; pfam02447 1037911012357 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1037911012358 AAA domain; Region: AAA_33; pfam13671 1037911012359 ATP-binding site [chemical binding]; other site 1037911012360 Gluconate-6-phosphate binding site [chemical binding]; other site 1037911012361 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1037911012362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1037911012363 DNA binding site [nucleotide binding] 1037911012364 domain linker motif; other site 1037911012365 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1037911012366 putative ligand binding site [chemical binding]; other site 1037911012367 putative dimerization interface [polypeptide binding]; other site 1037911012368 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911012369 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1037911012370 putative C-terminal domain interface [polypeptide binding]; other site 1037911012371 putative GSH binding site (G-site) [chemical binding]; other site 1037911012372 putative dimer interface [polypeptide binding]; other site 1037911012373 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1037911012374 putative N-terminal domain interface [polypeptide binding]; other site 1037911012375 putative dimer interface [polypeptide binding]; other site 1037911012376 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911012377 benzoate transport; Region: 2A0115; TIGR00895 1037911012378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911012379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911012380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911012381 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1037911012382 putative active site [active] 1037911012383 heme pocket [chemical binding]; other site 1037911012384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911012385 putative active site [active] 1037911012386 heme pocket [chemical binding]; other site 1037911012387 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911012388 dimer interface [polypeptide binding]; other site 1037911012389 putative CheW interface [polypeptide binding]; other site 1037911012390 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1037911012391 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911012392 substrate binding pocket [chemical binding]; other site 1037911012393 membrane-bound complex binding site; other site 1037911012394 hinge residues; other site 1037911012395 RNA polymerase sigma factor; Provisional; Region: PRK12525 1037911012396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911012397 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911012398 DNA binding residues [nucleotide binding] 1037911012399 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1037911012400 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1037911012401 putative di-iron ligands [ion binding]; other site 1037911012402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911012403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1037911012404 Coenzyme A binding pocket [chemical binding]; other site 1037911012405 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1037911012406 active site 1037911012407 catalytic residues [active] 1037911012408 metal binding site [ion binding]; metal-binding site 1037911012409 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1037911012410 CsbD-like; Region: CsbD; pfam05532 1037911012411 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1037911012412 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1037911012413 acyl-activating enzyme (AAE) consensus motif; other site 1037911012414 putative AMP binding site [chemical binding]; other site 1037911012415 putative active site [active] 1037911012416 putative CoA binding site [chemical binding]; other site 1037911012417 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 1037911012418 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1037911012419 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1037911012420 acyl-activating enzyme (AAE) consensus motif; other site 1037911012421 putative AMP binding site [chemical binding]; other site 1037911012422 putative active site [active] 1037911012423 putative CoA binding site [chemical binding]; other site 1037911012424 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1037911012425 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911012426 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1037911012427 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1037911012428 dimer interaction site [polypeptide binding]; other site 1037911012429 substrate-binding tunnel; other site 1037911012430 active site 1037911012431 catalytic site [active] 1037911012432 substrate binding site [chemical binding]; other site 1037911012433 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1037911012434 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1037911012435 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1037911012436 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1037911012437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911012438 catalytic residue [active] 1037911012439 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1037911012440 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1037911012441 active site 1037911012442 intersubunit interface [polypeptide binding]; other site 1037911012443 catalytic residue [active] 1037911012444 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1037911012445 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1037911012446 putative active site [active] 1037911012447 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1037911012448 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1037911012449 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1037911012450 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1037911012451 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1037911012452 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1037911012453 putative active site [active] 1037911012454 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1037911012455 active site 1037911012456 phosphate binding residues; other site 1037911012457 catalytic residues [active] 1037911012458 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1037911012459 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1037911012460 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1037911012461 Walker A/P-loop; other site 1037911012462 ATP binding site [chemical binding]; other site 1037911012463 Q-loop/lid; other site 1037911012464 ABC transporter signature motif; other site 1037911012465 Walker B; other site 1037911012466 D-loop; other site 1037911012467 H-loop/switch region; other site 1037911012468 TOBE domain; Region: TOBE_2; pfam08402 1037911012469 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1037911012470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911012471 dimer interface [polypeptide binding]; other site 1037911012472 conserved gate region; other site 1037911012473 putative PBP binding loops; other site 1037911012474 ABC-ATPase subunit interface; other site 1037911012475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911012476 dimer interface [polypeptide binding]; other site 1037911012477 conserved gate region; other site 1037911012478 putative PBP binding loops; other site 1037911012479 ABC-ATPase subunit interface; other site 1037911012480 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1037911012481 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1037911012482 dimerization interface [polypeptide binding]; other site 1037911012483 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1037911012484 putative active cleft [active] 1037911012485 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1037911012486 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1037911012487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911012488 NAD(P) binding site [chemical binding]; other site 1037911012489 active site 1037911012490 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1037911012491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911012492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911012493 dimerization interface [polypeptide binding]; other site 1037911012494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1037911012495 ACT domain; Region: ACT_3; pfam10000 1037911012496 Family description; Region: ACT_7; pfam13840 1037911012497 Lysine efflux permease [General function prediction only]; Region: COG1279 1037911012498 superoxide dismutase; Provisional; Region: PRK10543 1037911012499 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1037911012500 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1037911012501 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1037911012502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911012503 metal binding site [ion binding]; metal-binding site 1037911012504 active site 1037911012505 I-site; other site 1037911012506 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911012507 Imelysin; Region: Peptidase_M75; cl09159 1037911012508 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1037911012509 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1037911012510 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1037911012511 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911012512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911012513 Protein of unknown function (DUF962); Region: DUF962; cl01879 1037911012514 major facilitator superfamily transporter; Provisional; Region: PRK05122 1037911012515 hypothetical protein; Provisional; Region: PRK09256 1037911012516 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1037911012517 aromatic amino acid transporter; Provisional; Region: PRK10238 1037911012518 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1037911012519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1037911012520 RNA binding surface [nucleotide binding]; other site 1037911012521 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1037911012522 probable active site [active] 1037911012523 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1037911012524 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1037911012525 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1037911012526 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1037911012527 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1037911012528 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1037911012529 active site 1037911012530 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1037911012531 intracellular septation protein A; Reviewed; Region: PRK00259 1037911012532 YciI-like protein; Reviewed; Region: PRK11370 1037911012533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911012534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012535 active site 1037911012536 phosphorylation site [posttranslational modification] 1037911012537 intermolecular recognition site; other site 1037911012538 dimerization interface [polypeptide binding]; other site 1037911012539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911012540 DNA binding site [nucleotide binding] 1037911012541 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1037911012542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911012543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911012544 ATP binding site [chemical binding]; other site 1037911012545 Mg2+ binding site [ion binding]; other site 1037911012546 G-X-G motif; other site 1037911012547 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1037911012548 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1037911012549 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1037911012550 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1037911012551 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1037911012552 minor groove reading motif; other site 1037911012553 helix-hairpin-helix signature motif; other site 1037911012554 substrate binding pocket [chemical binding]; other site 1037911012555 active site 1037911012556 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1037911012557 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1037911012558 arginine deiminase; Provisional; Region: PRK01388 1037911012559 ornithine carbamoyltransferase; Validated; Region: PRK02102 1037911012560 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1037911012561 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1037911012562 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1037911012563 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1037911012564 putative substrate binding site [chemical binding]; other site 1037911012565 nucleotide binding site [chemical binding]; other site 1037911012566 nucleotide binding site [chemical binding]; other site 1037911012567 homodimer interface [polypeptide binding]; other site 1037911012568 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1037911012569 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1037911012570 putative aromatic amino acid binding site; other site 1037911012571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911012572 putative active site [active] 1037911012573 heme pocket [chemical binding]; other site 1037911012574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911012575 Walker A motif; other site 1037911012576 ATP binding site [chemical binding]; other site 1037911012577 Walker B motif; other site 1037911012578 arginine finger; other site 1037911012579 glycine cleavage system protein H; Provisional; Region: PRK13380 1037911012580 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1037911012581 lipoyl attachment site [posttranslational modification]; other site 1037911012582 glycine dehydrogenase; Provisional; Region: PRK05367 1037911012583 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1037911012584 tetramer interface [polypeptide binding]; other site 1037911012585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911012586 catalytic residue [active] 1037911012587 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1037911012588 tetramer interface [polypeptide binding]; other site 1037911012589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911012590 catalytic residue [active] 1037911012591 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1037911012592 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1037911012593 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1037911012594 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1037911012595 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1037911012596 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1037911012597 DNA-binding site [nucleotide binding]; DNA binding site 1037911012598 RNA-binding motif; other site 1037911012599 RDD family; Region: RDD; pfam06271 1037911012600 quinolinate synthetase; Provisional; Region: PRK09375 1037911012601 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1037911012602 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911012603 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911012604 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911012605 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911012606 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911012607 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1037911012608 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1037911012609 putative hydrophobic ligand binding site [chemical binding]; other site 1037911012610 protein interface [polypeptide binding]; other site 1037911012611 gate; other site 1037911012612 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1037911012613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911012614 putative substrate translocation pore; other site 1037911012615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911012616 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1037911012617 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1037911012618 HlyD family secretion protein; Region: HlyD_3; pfam13437 1037911012619 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1037911012620 Cupin domain; Region: Cupin_2; pfam07883 1037911012621 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911012622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911012623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911012624 2-isopropylmalate synthase; Validated; Region: PRK03739 1037911012625 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1037911012626 active site 1037911012627 catalytic residues [active] 1037911012628 metal binding site [ion binding]; metal-binding site 1037911012629 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1037911012630 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1037911012631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911012632 FeS/SAM binding site; other site 1037911012633 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1037911012634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1037911012635 binding surface 1037911012636 TPR motif; other site 1037911012637 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1037911012638 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911012639 ligand binding site [chemical binding]; other site 1037911012640 translocation protein TolB; Provisional; Region: tolB; PRK00178 1037911012641 TolB amino-terminal domain; Region: TolB_N; pfam04052 1037911012642 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1037911012643 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1037911012644 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1037911012645 TolA protein; Region: tolA_full; TIGR02794 1037911012646 TolA protein; Region: tolA_full; TIGR02794 1037911012647 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1037911012648 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1037911012649 TolR protein; Region: tolR; TIGR02801 1037911012650 TolQ protein; Region: tolQ; TIGR02796 1037911012651 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1037911012652 active site 1037911012653 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1037911012654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911012655 Walker A motif; other site 1037911012656 ATP binding site [chemical binding]; other site 1037911012657 Walker B motif; other site 1037911012658 arginine finger; other site 1037911012659 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1037911012660 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1037911012661 RuvA N terminal domain; Region: RuvA_N; pfam01330 1037911012662 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1037911012663 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1037911012664 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1037911012665 active site 1037911012666 putative DNA-binding cleft [nucleotide binding]; other site 1037911012667 dimer interface [polypeptide binding]; other site 1037911012668 hypothetical protein; Validated; Region: PRK00110 1037911012669 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1037911012670 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1037911012671 dimer interface [polypeptide binding]; other site 1037911012672 anticodon binding site; other site 1037911012673 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1037911012674 homodimer interface [polypeptide binding]; other site 1037911012675 motif 1; other site 1037911012676 active site 1037911012677 motif 2; other site 1037911012678 GAD domain; Region: GAD; pfam02938 1037911012679 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1037911012680 active site 1037911012681 motif 3; other site 1037911012682 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1037911012683 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1037911012684 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1037911012685 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1037911012686 dimerization interface [polypeptide binding]; other site 1037911012687 DPS ferroxidase diiron center [ion binding]; other site 1037911012688 ion pore; other site 1037911012689 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1037911012690 DNA-binding site [nucleotide binding]; DNA binding site 1037911012691 RNA-binding motif; other site 1037911012692 hypothetical protein; Provisional; Region: PRK00295 1037911012693 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1037911012694 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911012695 mechanosensitive channel MscS; Provisional; Region: PRK10334 1037911012696 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1037911012697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1037911012698 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1037911012699 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1037911012700 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1037911012701 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1037911012702 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911012703 dimerization interface [polypeptide binding]; other site 1037911012704 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1037911012705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911012706 putative active site [active] 1037911012707 heme pocket [chemical binding]; other site 1037911012708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911012709 dimer interface [polypeptide binding]; other site 1037911012710 phosphorylation site [posttranslational modification] 1037911012711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911012712 ATP binding site [chemical binding]; other site 1037911012713 Mg2+ binding site [ion binding]; other site 1037911012714 G-X-G motif; other site 1037911012715 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1037911012716 hypothetical protein; Provisional; Region: PRK08999 1037911012717 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1037911012718 active site 1037911012719 8-oxo-dGMP binding site [chemical binding]; other site 1037911012720 nudix motif; other site 1037911012721 metal binding site [ion binding]; metal-binding site 1037911012722 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1037911012723 thiamine phosphate binding site [chemical binding]; other site 1037911012724 active site 1037911012725 pyrophosphate binding site [ion binding]; other site 1037911012726 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1037911012727 heterotetramer interface [polypeptide binding]; other site 1037911012728 active site pocket [active] 1037911012729 cleavage site 1037911012730 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1037911012731 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1037911012732 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1037911012733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1037911012734 nucleotide binding region [chemical binding]; other site 1037911012735 ATP-binding site [chemical binding]; other site 1037911012736 SEC-C motif; Region: SEC-C; pfam02810 1037911012737 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1037911012738 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1037911012739 Cache domain; Region: Cache_1; pfam02743 1037911012740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911012741 dimerization interface [polypeptide binding]; other site 1037911012742 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1037911012743 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911012744 dimer interface [polypeptide binding]; other site 1037911012745 putative CheW interface [polypeptide binding]; other site 1037911012746 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911012747 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1037911012748 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1037911012749 Predicted deacetylase [General function prediction only]; Region: COG3233 1037911012750 putative active site [active] 1037911012751 putative Zn binding site [ion binding]; other site 1037911012752 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1037911012753 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1037911012754 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1037911012755 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1037911012756 putative active site [active] 1037911012757 putative substrate binding site [chemical binding]; other site 1037911012758 putative cosubstrate binding site; other site 1037911012759 catalytic site [active] 1037911012760 exonuclease I; Provisional; Region: sbcB; PRK11779 1037911012761 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1037911012762 active site 1037911012763 catalytic site [active] 1037911012764 substrate binding site [chemical binding]; other site 1037911012765 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1037911012766 RDD family; Region: RDD; pfam06271 1037911012767 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1037911012768 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1037911012769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911012770 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1037911012771 Walker A motif; other site 1037911012772 ATP binding site [chemical binding]; other site 1037911012773 Walker B motif; other site 1037911012774 arginine finger; other site 1037911012775 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1037911012776 Protein of unknown function DUF58; Region: DUF58; pfam01882 1037911012777 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1037911012778 metal ion-dependent adhesion site (MIDAS); other site 1037911012779 PilZ domain; Region: PilZ; pfam07238 1037911012780 pyruvate kinase; Provisional; Region: PRK05826 1037911012781 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1037911012782 domain interfaces; other site 1037911012783 active site 1037911012784 hypothetical protein; Provisional; Region: PRK05713 1037911012785 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911012786 catalytic loop [active] 1037911012787 iron binding site [ion binding]; other site 1037911012788 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1037911012789 FAD binding pocket [chemical binding]; other site 1037911012790 FAD binding motif [chemical binding]; other site 1037911012791 phosphate binding motif [ion binding]; other site 1037911012792 beta-alpha-beta structure motif; other site 1037911012793 NAD binding pocket [chemical binding]; other site 1037911012794 putative fumarate hydratase; Provisional; Region: PRK15392 1037911012795 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1037911012796 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1037911012797 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1037911012798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911012799 dimer interface [polypeptide binding]; other site 1037911012800 phosphorylation site [posttranslational modification] 1037911012801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911012802 ATP binding site [chemical binding]; other site 1037911012803 Mg2+ binding site [ion binding]; other site 1037911012804 G-X-G motif; other site 1037911012805 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911012806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012807 active site 1037911012808 phosphorylation site [posttranslational modification] 1037911012809 intermolecular recognition site; other site 1037911012810 dimerization interface [polypeptide binding]; other site 1037911012811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911012812 Walker A motif; other site 1037911012813 ATP binding site [chemical binding]; other site 1037911012814 Walker B motif; other site 1037911012815 arginine finger; other site 1037911012816 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1037911012817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911012818 putative substrate translocation pore; other site 1037911012819 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1037911012820 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1037911012821 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1037911012822 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1037911012823 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1037911012824 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1037911012825 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1037911012826 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911012827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911012828 HAMP domain; Region: HAMP; pfam00672 1037911012829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911012830 ATP binding site [chemical binding]; other site 1037911012831 Mg2+ binding site [ion binding]; other site 1037911012832 G-X-G motif; other site 1037911012833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911012834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012835 active site 1037911012836 phosphorylation site [posttranslational modification] 1037911012837 intermolecular recognition site; other site 1037911012838 dimerization interface [polypeptide binding]; other site 1037911012839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911012840 DNA binding site [nucleotide binding] 1037911012841 glucokinase, proteobacterial type; Region: glk; TIGR00749 1037911012842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1037911012843 nucleotide binding site [chemical binding]; other site 1037911012844 phosphogluconate dehydratase; Validated; Region: PRK09054 1037911012845 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1037911012846 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1037911012847 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1037911012848 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1037911012849 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1037911012850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911012851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911012852 DNA binding residues [nucleotide binding] 1037911012853 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1037911012854 FecR protein; Region: FecR; pfam04773 1037911012855 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911012856 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1037911012857 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911012858 N-terminal plug; other site 1037911012859 ligand-binding site [chemical binding]; other site 1037911012860 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1037911012861 heme binding pocket [chemical binding]; other site 1037911012862 heme ligand [chemical binding]; other site 1037911012863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1037911012864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911012865 dimerization interface [polypeptide binding]; other site 1037911012866 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911012867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911012868 dimer interface [polypeptide binding]; other site 1037911012869 putative CheW interface [polypeptide binding]; other site 1037911012870 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1037911012871 putative FMN binding site [chemical binding]; other site 1037911012872 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1037911012873 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1037911012874 Imelysin; Region: Peptidase_M75; cl09159 1037911012875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 1037911012876 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1037911012877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911012878 S-adenosylmethionine binding site [chemical binding]; other site 1037911012879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911012880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911012881 dimer interface [polypeptide binding]; other site 1037911012882 phosphorylation site [posttranslational modification] 1037911012883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911012884 ATP binding site [chemical binding]; other site 1037911012885 Mg2+ binding site [ion binding]; other site 1037911012886 G-X-G motif; other site 1037911012887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1037911012888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012889 active site 1037911012890 phosphorylation site [posttranslational modification] 1037911012891 intermolecular recognition site; other site 1037911012892 dimerization interface [polypeptide binding]; other site 1037911012893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911012894 DNA binding site [nucleotide binding] 1037911012895 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1037911012896 Sulfatase; Region: Sulfatase; pfam00884 1037911012897 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1037911012898 active site 1037911012899 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1037911012900 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1037911012901 ring oligomerisation interface [polypeptide binding]; other site 1037911012902 ATP/Mg binding site [chemical binding]; other site 1037911012903 stacking interactions; other site 1037911012904 hinge regions; other site 1037911012905 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1037911012906 oligomerisation interface [polypeptide binding]; other site 1037911012907 mobile loop; other site 1037911012908 roof hairpin; other site 1037911012909 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1037911012910 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1037911012911 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1037911012912 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1037911012913 Sm and related proteins; Region: Sm_like; cl00259 1037911012914 Sm1 motif; other site 1037911012915 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1037911012916 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1037911012917 DNA binding site [nucleotide binding] 1037911012918 active site 1037911012919 muropeptide transporter; Validated; Region: ampG; cl17669 1037911012920 muropeptide transporter; Validated; Region: ampG; cl17669 1037911012921 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1037911012922 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1037911012923 dimer interface [polypeptide binding]; other site 1037911012924 motif 1; other site 1037911012925 active site 1037911012926 motif 2; other site 1037911012927 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1037911012928 putative deacylase active site [active] 1037911012929 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1037911012930 active site 1037911012931 motif 3; other site 1037911012932 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1037911012933 anticodon binding site; other site 1037911012934 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1037911012935 active site 1037911012936 DNA polymerase IV; Validated; Region: PRK02406 1037911012937 DNA binding site [nucleotide binding] 1037911012938 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1037911012939 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1037911012940 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1037911012941 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1037911012942 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1037911012943 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1037911012944 DHH family; Region: DHH; pfam01368 1037911012945 DHHA1 domain; Region: DHHA1; pfam02272 1037911012946 YaeQ protein; Region: YaeQ; pfam07152 1037911012947 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1037911012948 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1037911012949 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1037911012950 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911012951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012952 active site 1037911012953 phosphorylation site [posttranslational modification] 1037911012954 intermolecular recognition site; other site 1037911012955 dimerization interface [polypeptide binding]; other site 1037911012956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911012957 DNA binding residues [nucleotide binding] 1037911012958 dimerization interface [polypeptide binding]; other site 1037911012959 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911012960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012961 active site 1037911012962 phosphorylation site [posttranslational modification] 1037911012963 intermolecular recognition site; other site 1037911012964 dimerization interface [polypeptide binding]; other site 1037911012965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911012966 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1037911012967 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911012968 substrate binding pocket [chemical binding]; other site 1037911012969 membrane-bound complex binding site; other site 1037911012970 hinge residues; other site 1037911012971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911012972 substrate binding pocket [chemical binding]; other site 1037911012973 membrane-bound complex binding site; other site 1037911012974 hinge residues; other site 1037911012975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911012976 putative active site [active] 1037911012977 heme pocket [chemical binding]; other site 1037911012978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911012979 dimer interface [polypeptide binding]; other site 1037911012980 phosphorylation site [posttranslational modification] 1037911012981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911012982 ATP binding site [chemical binding]; other site 1037911012983 Mg2+ binding site [ion binding]; other site 1037911012984 G-X-G motif; other site 1037911012985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911012986 active site 1037911012987 phosphorylation site [posttranslational modification] 1037911012988 intermolecular recognition site; other site 1037911012989 dimerization interface [polypeptide binding]; other site 1037911012990 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911012991 putative binding surface; other site 1037911012992 active site 1037911012993 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1037911012994 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1037911012995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911012996 catalytic residue [active] 1037911012997 homoserine dehydrogenase; Provisional; Region: PRK06349 1037911012998 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1037911012999 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1037911013000 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1037911013001 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1037911013002 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1037911013003 dimerization domain [polypeptide binding]; other site 1037911013004 dimer interface [polypeptide binding]; other site 1037911013005 catalytic residues [active] 1037911013006 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1037911013007 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1037911013008 active site 1037911013009 Int/Topo IB signature motif; other site 1037911013010 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1037911013011 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1037911013012 TrkA-N domain; Region: TrkA_N; pfam02254 1037911013013 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1037911013014 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1037911013015 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1037911013016 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1037911013017 RimM N-terminal domain; Region: RimM; pfam01782 1037911013018 PRC-barrel domain; Region: PRC; pfam05239 1037911013019 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1037911013020 signal recognition particle protein; Provisional; Region: PRK10867 1037911013021 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1037911013022 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1037911013023 P loop; other site 1037911013024 GTP binding site [chemical binding]; other site 1037911013025 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1037911013026 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1037911013027 hypothetical protein; Provisional; Region: PRK11573 1037911013028 Domain of unknown function DUF21; Region: DUF21; pfam01595 1037911013029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1037911013030 Transporter associated domain; Region: CorC_HlyC; smart01091 1037911013031 metabolite-proton symporter; Region: 2A0106; TIGR00883 1037911013032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911013033 putative substrate translocation pore; other site 1037911013034 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1037911013035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911013036 ATP-grasp domain; Region: ATP-grasp; pfam02222 1037911013037 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1037911013038 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1037911013039 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1037911013040 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1037911013041 trimer interface [polypeptide binding]; other site 1037911013042 putative metal binding site [ion binding]; other site 1037911013043 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1037911013044 putative active site [active] 1037911013045 putative CoA binding site [chemical binding]; other site 1037911013046 nudix motif; other site 1037911013047 metal binding site [ion binding]; metal-binding site 1037911013048 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1037911013049 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1037911013050 nudix motif; other site 1037911013051 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1037911013052 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1037911013053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911013054 DNA-binding site [nucleotide binding]; DNA binding site 1037911013055 UTRA domain; Region: UTRA; pfam07702 1037911013056 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1037911013057 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1037911013058 active site 1037911013059 dimer interface [polypeptide binding]; other site 1037911013060 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1037911013061 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1037911013062 dimer interface [polypeptide binding]; other site 1037911013063 active site 1037911013064 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1037911013065 dimer interface [polypeptide binding]; other site 1037911013066 active site 1037911013067 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1037911013068 HPr interaction site; other site 1037911013069 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1037911013070 active site 1037911013071 phosphorylation site [posttranslational modification] 1037911013072 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1037911013073 dimerization domain swap beta strand [polypeptide binding]; other site 1037911013074 regulatory protein interface [polypeptide binding]; other site 1037911013075 active site 1037911013076 regulatory phosphorylation site [posttranslational modification]; other site 1037911013077 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1037911013078 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1037911013079 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1037911013080 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1037911013081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1037911013082 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1037911013083 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 1037911013084 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1037911013085 active site turn [active] 1037911013086 phosphorylation site [posttranslational modification] 1037911013087 phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367 1037911013088 active site turn [active] 1037911013089 phosphorylation site [posttranslational modification] 1037911013090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1037911013091 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1037911013092 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1037911013093 dimerization interface [polypeptide binding]; other site 1037911013094 ATP binding site [chemical binding]; other site 1037911013095 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1037911013096 dimerization interface [polypeptide binding]; other site 1037911013097 ATP binding site [chemical binding]; other site 1037911013098 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1037911013099 putative active site [active] 1037911013100 catalytic triad [active] 1037911013101 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1037911013102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911013103 substrate binding pocket [chemical binding]; other site 1037911013104 membrane-bound complex binding site; other site 1037911013105 hinge residues; other site 1037911013106 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1037911013107 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1037911013108 catalytic residue [active] 1037911013109 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1037911013110 active site turn [active] 1037911013111 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1037911013112 HPr interaction site; other site 1037911013113 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1037911013114 active site 1037911013115 phosphorylation site [posttranslational modification] 1037911013116 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1037911013117 dimerization domain swap beta strand [polypeptide binding]; other site 1037911013118 regulatory protein interface [polypeptide binding]; other site 1037911013119 active site 1037911013120 regulatory phosphorylation site [posttranslational modification]; other site 1037911013121 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1037911013122 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1037911013123 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1037911013124 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1037911013125 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1037911013126 trimer interface; other site 1037911013127 sugar binding site [chemical binding]; other site 1037911013128 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1037911013129 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1037911013130 Ca binding site [ion binding]; other site 1037911013131 active site 1037911013132 catalytic site [active] 1037911013133 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1037911013134 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1037911013135 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1037911013136 active site turn [active] 1037911013137 phosphorylation site [posttranslational modification] 1037911013138 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1037911013139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911013140 DNA-binding site [nucleotide binding]; DNA binding site 1037911013141 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1037911013142 UTRA domain; Region: UTRA; pfam07702 1037911013143 GMP synthase; Reviewed; Region: guaA; PRK00074 1037911013144 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1037911013145 AMP/PPi binding site [chemical binding]; other site 1037911013146 candidate oxyanion hole; other site 1037911013147 catalytic triad [active] 1037911013148 potential glutamine specificity residues [chemical binding]; other site 1037911013149 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1037911013150 ATP Binding subdomain [chemical binding]; other site 1037911013151 Ligand Binding sites [chemical binding]; other site 1037911013152 Dimerization subdomain; other site 1037911013153 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1037911013154 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1037911013155 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1037911013156 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1037911013157 active site 1037911013158 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1037911013159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911013160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911013161 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1037911013162 dimerization interface [polypeptide binding]; other site 1037911013163 substrate binding pocket [chemical binding]; other site 1037911013164 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1037911013165 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1037911013166 generic binding surface II; other site 1037911013167 generic binding surface I; other site 1037911013168 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1037911013169 Peptidase family M23; Region: Peptidase_M23; pfam01551 1037911013170 2-isopropylmalate synthase; Validated; Region: PRK03739 1037911013171 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1037911013172 active site 1037911013173 catalytic residues [active] 1037911013174 metal binding site [ion binding]; metal-binding site 1037911013175 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1037911013176 C-N hydrolase family amidase; Provisional; Region: PRK10438 1037911013177 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1037911013178 putative active site [active] 1037911013179 catalytic triad [active] 1037911013180 dimer interface [polypeptide binding]; other site 1037911013181 multimer interface [polypeptide binding]; other site 1037911013182 methionine aminotransferase; Validated; Region: PRK09082 1037911013183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911013184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911013185 homodimer interface [polypeptide binding]; other site 1037911013186 catalytic residue [active] 1037911013187 GTP-binding protein Der; Reviewed; Region: PRK00093 1037911013188 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1037911013189 G1 box; other site 1037911013190 GTP/Mg2+ binding site [chemical binding]; other site 1037911013191 Switch I region; other site 1037911013192 G2 box; other site 1037911013193 Switch II region; other site 1037911013194 G3 box; other site 1037911013195 G4 box; other site 1037911013196 G5 box; other site 1037911013197 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1037911013198 G1 box; other site 1037911013199 GTP/Mg2+ binding site [chemical binding]; other site 1037911013200 Switch I region; other site 1037911013201 G2 box; other site 1037911013202 G3 box; other site 1037911013203 Switch II region; other site 1037911013204 G4 box; other site 1037911013205 G5 box; other site 1037911013206 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1037911013207 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1037911013208 Trp docking motif [polypeptide binding]; other site 1037911013209 active site 1037911013210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1037911013211 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1037911013212 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1037911013213 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1037911013214 dimer interface [polypeptide binding]; other site 1037911013215 motif 1; other site 1037911013216 active site 1037911013217 motif 2; other site 1037911013218 motif 3; other site 1037911013219 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1037911013220 anticodon binding site; other site 1037911013221 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1037911013222 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1037911013223 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1037911013224 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1037911013225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911013226 non-specific DNA binding site [nucleotide binding]; other site 1037911013227 salt bridge; other site 1037911013228 sequence-specific DNA binding site [nucleotide binding]; other site 1037911013229 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1037911013230 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1037911013231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911013232 binding surface 1037911013233 TPR motif; other site 1037911013234 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1037911013235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911013236 FeS/SAM binding site; other site 1037911013237 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1037911013238 active site 1037911013239 multimer interface [polypeptide binding]; other site 1037911013240 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1037911013241 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1037911013242 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911013243 catalytic loop [active] 1037911013244 iron binding site [ion binding]; other site 1037911013245 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1037911013246 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1037911013247 nucleotide binding site [chemical binding]; other site 1037911013248 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1037911013249 SBD interface [polypeptide binding]; other site 1037911013250 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1037911013251 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1037911013252 HSP70 interaction site [polypeptide binding]; other site 1037911013253 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1037911013254 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1037911013255 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1037911013256 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1037911013257 trimerization site [polypeptide binding]; other site 1037911013258 active site 1037911013259 cysteine desulfurase; Provisional; Region: PRK14012 1037911013260 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1037911013261 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911013262 catalytic residue [active] 1037911013263 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1037911013264 Rrf2 family protein; Region: rrf2_super; TIGR00738 1037911013265 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1037911013266 serine O-acetyltransferase; Region: cysE; TIGR01172 1037911013267 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1037911013268 trimer interface [polypeptide binding]; other site 1037911013269 active site 1037911013270 substrate binding site [chemical binding]; other site 1037911013271 CoA binding site [chemical binding]; other site 1037911013272 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1037911013273 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1037911013274 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1037911013275 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1037911013276 active site 1037911013277 dimerization interface [polypeptide binding]; other site 1037911013278 hypothetical protein; Provisional; Region: PRK11280 1037911013279 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1037911013280 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1037911013281 Protein export membrane protein; Region: SecD_SecF; pfam02355 1037911013282 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1037911013283 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1037911013284 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1037911013285 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1037911013286 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1037911013287 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1037911013288 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1037911013289 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1037911013290 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1037911013291 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 1037911013292 active site 1037911013293 LysE type translocator; Region: LysE; cl00565 1037911013294 gibberellin 2-beta-dioxygenase; Region: PLN02156 1037911013295 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1037911013296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1037911013297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911013298 non-specific DNA binding site [nucleotide binding]; other site 1037911013299 salt bridge; other site 1037911013300 sequence-specific DNA binding site [nucleotide binding]; other site 1037911013301 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1037911013302 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1037911013303 pentamer interface [polypeptide binding]; other site 1037911013304 dodecaamer interface [polypeptide binding]; other site 1037911013305 PIN domain; Region: PIN_3; pfam13470 1037911013306 DNA binding domain, excisionase family; Region: excise; TIGR01764 1037911013307 S-type Pyocin; Region: Pyocin_S; pfam06958 1037911013308 Cytotoxic; Region: Cytotoxic; pfam09000 1037911013309 Cloacin immunity protein; Region: Cloacin_immun; pfam03513 1037911013310 Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140 1037911013311 putative RNAase interaction site [polypeptide binding]; other site 1037911013312 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1037911013313 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1037911013314 dimer interface [polypeptide binding]; other site 1037911013315 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911013316 ligand binding site [chemical binding]; other site 1037911013317 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1037911013318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911013319 active site 1037911013320 phosphorylation site [posttranslational modification] 1037911013321 intermolecular recognition site; other site 1037911013322 dimerization interface [polypeptide binding]; other site 1037911013323 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1037911013324 heme binding pocket [chemical binding]; other site 1037911013325 heme ligand [chemical binding]; other site 1037911013326 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1037911013327 GAF domain; Region: GAF; pfam01590 1037911013328 Phytochrome region; Region: PHY; pfam00360 1037911013329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911013330 dimer interface [polypeptide binding]; other site 1037911013331 phosphorylation site [posttranslational modification] 1037911013332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911013333 ATP binding site [chemical binding]; other site 1037911013334 Mg2+ binding site [ion binding]; other site 1037911013335 G-X-G motif; other site 1037911013336 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1037911013337 metal binding site [ion binding]; metal-binding site 1037911013338 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1037911013339 putative active site [active] 1037911013340 putative metal binding site [ion binding]; other site 1037911013341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911013342 PAS fold; Region: PAS_3; pfam08447 1037911013343 putative active site [active] 1037911013344 heme pocket [chemical binding]; other site 1037911013345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911013346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911013347 metal binding site [ion binding]; metal-binding site 1037911013348 active site 1037911013349 I-site; other site 1037911013350 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1037911013351 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911013352 inhibitor-cofactor binding pocket; inhibition site 1037911013353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911013354 catalytic residue [active] 1037911013355 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1037911013356 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1037911013357 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1037911013358 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1037911013359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911013360 catalytic residue [active] 1037911013361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911013362 putative substrate translocation pore; other site 1037911013363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911013364 hypothetical protein; Provisional; Region: PRK07206 1037911013365 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1037911013366 Proline dehydrogenase; Region: Pro_dh; cl03282 1037911013367 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1037911013368 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1037911013369 putative di-iron ligands [ion binding]; other site 1037911013370 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1037911013371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1037911013372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911013373 DNA binding residues [nucleotide binding] 1037911013374 dimerization interface [polypeptide binding]; other site 1037911013375 putative aminotransferase; Provisional; Region: PRK09105 1037911013376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911013377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911013378 homodimer interface [polypeptide binding]; other site 1037911013379 catalytic residue [active] 1037911013380 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1037911013381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911013382 non-specific DNA binding site [nucleotide binding]; other site 1037911013383 salt bridge; other site 1037911013384 sequence-specific DNA binding site [nucleotide binding]; other site 1037911013385 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1037911013386 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1037911013387 Ligand Binding Site [chemical binding]; other site 1037911013388 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1037911013389 UbiA prenyltransferase family; Region: UbiA; pfam01040 1037911013390 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1037911013391 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1037911013392 Subunit I/III interface [polypeptide binding]; other site 1037911013393 Subunit III/IV interface [polypeptide binding]; other site 1037911013394 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1037911013395 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1037911013396 D-pathway; other site 1037911013397 Putative ubiquinol binding site [chemical binding]; other site 1037911013398 Low-spin heme (heme b) binding site [chemical binding]; other site 1037911013399 Putative water exit pathway; other site 1037911013400 Binuclear center (heme o3/CuB) [ion binding]; other site 1037911013401 K-pathway; other site 1037911013402 Putative proton exit pathway; other site 1037911013403 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1037911013404 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1037911013405 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1037911013406 disulfide bond formation protein B; Provisional; Region: PRK02110 1037911013407 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1037911013408 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1037911013409 heme-binding site [chemical binding]; other site 1037911013410 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1037911013411 FAD binding pocket [chemical binding]; other site 1037911013412 FAD binding motif [chemical binding]; other site 1037911013413 phosphate binding motif [ion binding]; other site 1037911013414 beta-alpha-beta structure motif; other site 1037911013415 NAD binding pocket [chemical binding]; other site 1037911013416 Heme binding pocket [chemical binding]; other site 1037911013417 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1037911013418 GAF domain; Region: GAF; pfam01590 1037911013419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911013420 Walker A motif; other site 1037911013421 ATP binding site [chemical binding]; other site 1037911013422 Walker B motif; other site 1037911013423 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1037911013424 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1037911013425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911013426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911013427 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1037911013428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911013429 DNA binding residues [nucleotide binding] 1037911013430 dimerization interface [polypeptide binding]; other site 1037911013431 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1037911013432 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1037911013433 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1037911013434 homodimer interface [polypeptide binding]; other site 1037911013435 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1037911013436 NAD binding site [chemical binding]; other site 1037911013437 active site 1037911013438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911013439 aldolase II superfamily protein; Provisional; Region: PRK07044 1037911013440 intersubunit interface [polypeptide binding]; other site 1037911013441 active site 1037911013442 Zn2+ binding site [ion binding]; other site 1037911013443 flavodoxin; Provisional; Region: PRK05723 1037911013444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911013445 PAS domain; Region: PAS_9; pfam13426 1037911013446 putative active site [active] 1037911013447 heme pocket [chemical binding]; other site 1037911013448 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1037911013449 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1037911013450 DNA binding residues [nucleotide binding] 1037911013451 B12 binding domain; Region: B12-binding_2; pfam02607 1037911013452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1037911013453 dihydromonapterin reductase; Provisional; Region: PRK06483 1037911013454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911013455 NAD(P) binding site [chemical binding]; other site 1037911013456 active site 1037911013457 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1037911013458 homodecamer interface [polypeptide binding]; other site 1037911013459 GTP cyclohydrolase I; Provisional; Region: PLN03044 1037911013460 active site 1037911013461 putative catalytic site residues [active] 1037911013462 zinc binding site [ion binding]; other site 1037911013463 GTP-CH-I/GFRP interaction surface; other site 1037911013464 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 1037911013465 active site 1037911013466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1037911013467 HopJ type III effector protein; Region: HopJ; pfam08888 1037911013468 thioredoxin reductase; Provisional; Region: PRK10262 1037911013469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1037911013470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911013471 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1037911013472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1037911013473 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1037911013474 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1037911013475 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1037911013476 putative active site [active] 1037911013477 putative FMN binding site [chemical binding]; other site 1037911013478 putative substrate binding site [chemical binding]; other site 1037911013479 putative catalytic residue [active] 1037911013480 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1037911013481 catalytic residues [active] 1037911013482 dimer interface [polypeptide binding]; other site 1037911013483 CreA protein; Region: CreA; pfam05981 1037911013484 gamma-glutamyl kinase; Provisional; Region: PRK05429 1037911013485 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1037911013486 nucleotide binding site [chemical binding]; other site 1037911013487 homotetrameric interface [polypeptide binding]; other site 1037911013488 putative phosphate binding site [ion binding]; other site 1037911013489 putative allosteric binding site; other site 1037911013490 PUA domain; Region: PUA; pfam01472 1037911013491 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1037911013492 GTP1/OBG; Region: GTP1_OBG; pfam01018 1037911013493 Obg GTPase; Region: Obg; cd01898 1037911013494 G1 box; other site 1037911013495 GTP/Mg2+ binding site [chemical binding]; other site 1037911013496 Switch I region; other site 1037911013497 G2 box; other site 1037911013498 G3 box; other site 1037911013499 Switch II region; other site 1037911013500 G4 box; other site 1037911013501 G5 box; other site 1037911013502 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1037911013503 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1037911013504 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1037911013505 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1037911013506 substrate binding pocket [chemical binding]; other site 1037911013507 chain length determination region; other site 1037911013508 substrate-Mg2+ binding site; other site 1037911013509 catalytic residues [active] 1037911013510 aspartate-rich region 1; other site 1037911013511 active site lid residues [active] 1037911013512 aspartate-rich region 2; other site 1037911013513 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1037911013514 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1037911013515 PhnA protein; Region: PhnA; pfam03831 1037911013516 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1037911013517 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1037911013518 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1037911013519 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1037911013520 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911013521 dimerization interface [polypeptide binding]; other site 1037911013522 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911013523 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911013524 dimer interface [polypeptide binding]; other site 1037911013525 putative CheW interface [polypeptide binding]; other site 1037911013526 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1037911013527 dimer interface [polypeptide binding]; other site 1037911013528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911013529 ligand binding site [chemical binding]; other site 1037911013530 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1037911013531 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1037911013532 active site 1037911013533 putative substrate binding pocket [chemical binding]; other site 1037911013534 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1037911013535 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1037911013536 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1037911013537 putative active site [active] 1037911013538 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1037911013539 GntP family permease; Region: GntP_permease; pfam02447 1037911013540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1037911013541 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1037911013542 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1037911013543 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1037911013544 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1037911013545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911013546 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1037911013547 NAD(P) binding site [chemical binding]; other site 1037911013548 active site 1037911013549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911013550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911013551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911013552 dimerization interface [polypeptide binding]; other site 1037911013553 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1037911013554 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1037911013555 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1037911013556 kynureninase; Region: kynureninase; TIGR01814 1037911013557 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1037911013558 catalytic residue [active] 1037911013559 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1037911013560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911013561 putative DNA binding site [nucleotide binding]; other site 1037911013562 putative Zn2+ binding site [ion binding]; other site 1037911013563 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911013564 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1037911013565 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1037911013566 dimer interface [polypeptide binding]; other site 1037911013567 active site 1037911013568 Muconolactone delta-isomerase; Region: MIase; pfam02426 1037911013569 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1037911013570 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1037911013571 octamer interface [polypeptide binding]; other site 1037911013572 active site 1037911013573 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1037911013574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911013575 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1037911013576 dimerizarion interface [polypeptide binding]; other site 1037911013577 CrgA pocket; other site 1037911013578 substrate binding pocket [chemical binding]; other site 1037911013579 Helix-turn-helix domain; Region: HTH_18; pfam12833 1037911013580 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 1037911013581 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1037911013582 [2Fe-2S] cluster binding site [ion binding]; other site 1037911013583 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1037911013584 putative alpha subunit interface [polypeptide binding]; other site 1037911013585 putative active site [active] 1037911013586 putative substrate binding site [chemical binding]; other site 1037911013587 Fe binding site [ion binding]; other site 1037911013588 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1037911013589 inter-subunit interface; other site 1037911013590 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1037911013591 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911013592 catalytic loop [active] 1037911013593 iron binding site [ion binding]; other site 1037911013594 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1037911013595 FAD binding pocket [chemical binding]; other site 1037911013596 FAD binding motif [chemical binding]; other site 1037911013597 phosphate binding motif [ion binding]; other site 1037911013598 beta-alpha-beta structure motif; other site 1037911013599 NAD binding pocket [chemical binding]; other site 1037911013600 aromatic amino acid transporter; Provisional; Region: PRK10238 1037911013601 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1037911013602 arylformamidase; Region: trp_arylform; TIGR03035 1037911013603 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1037911013604 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1037911013605 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1037911013606 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1037911013607 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1037911013608 tetrameric interface [polypeptide binding]; other site 1037911013609 NAD binding site [chemical binding]; other site 1037911013610 catalytic residues [active] 1037911013611 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911013612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911013613 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1037911013614 dimerization interface [polypeptide binding]; other site 1037911013615 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911013616 ligand binding site [chemical binding]; other site 1037911013617 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1037911013618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911013619 metal binding site [ion binding]; metal-binding site 1037911013620 active site 1037911013621 I-site; other site 1037911013622 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1037911013623 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1037911013624 AAA domain; Region: AAA_30; pfam13604 1037911013625 Family description; Region: UvrD_C_2; pfam13538 1037911013626 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1037911013627 Family description; Region: UvrD_C_2; pfam13538 1037911013628 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1037911013629 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1037911013630 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1037911013631 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1037911013632 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1037911013633 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1037911013634 Moco binding site; other site 1037911013635 metal coordination site [ion binding]; other site 1037911013636 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1037911013637 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1037911013638 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1037911013639 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1037911013640 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1037911013641 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1037911013642 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1037911013643 putative valine binding site [chemical binding]; other site 1037911013644 dimer interface [polypeptide binding]; other site 1037911013645 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1037911013646 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1037911013647 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1037911013648 PYR/PP interface [polypeptide binding]; other site 1037911013649 dimer interface [polypeptide binding]; other site 1037911013650 TPP binding site [chemical binding]; other site 1037911013651 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1037911013652 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1037911013653 TPP-binding site [chemical binding]; other site 1037911013654 dimer interface [polypeptide binding]; other site 1037911013655 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1037911013656 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1037911013657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1037911013658 TPR motif; other site 1037911013659 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1037911013660 Transglycosylase; Region: Transgly; pfam00912 1037911013661 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1037911013662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1037911013663 AAA domain; Region: AAA_33; pfam13671 1037911013664 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1037911013665 active site 1037911013666 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1037911013667 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1037911013668 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1037911013669 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1037911013670 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1037911013671 Walker A/P-loop; other site 1037911013672 ATP binding site [chemical binding]; other site 1037911013673 Q-loop/lid; other site 1037911013674 ABC transporter signature motif; other site 1037911013675 Walker B; other site 1037911013676 D-loop; other site 1037911013677 H-loop/switch region; other site 1037911013678 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1037911013679 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1037911013680 ABC-ATPase subunit interface; other site 1037911013681 dimer interface [polypeptide binding]; other site 1037911013682 putative PBP binding regions; other site 1037911013683 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1037911013684 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1037911013685 intersubunit interface [polypeptide binding]; other site 1037911013686 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1037911013687 iron-sulfur cluster [ion binding]; other site 1037911013688 [2Fe-2S] cluster binding site [ion binding]; other site 1037911013689 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1037911013690 hypothetical protein; Provisional; Region: PRK08960 1037911013691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911013692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911013693 homodimer interface [polypeptide binding]; other site 1037911013694 catalytic residue [active] 1037911013695 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1037911013696 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1037911013697 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1037911013698 active site 1037911013699 HIGH motif; other site 1037911013700 nucleotide binding site [chemical binding]; other site 1037911013701 KMSKS motif; other site 1037911013702 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1037911013703 Na binding site [ion binding]; other site 1037911013704 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1037911013705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911013706 putative active site [active] 1037911013707 heme pocket [chemical binding]; other site 1037911013708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911013709 dimer interface [polypeptide binding]; other site 1037911013710 phosphorylation site [posttranslational modification] 1037911013711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911013712 ATP binding site [chemical binding]; other site 1037911013713 Mg2+ binding site [ion binding]; other site 1037911013714 G-X-G motif; other site 1037911013715 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1037911013716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911013717 active site 1037911013718 phosphorylation site [posttranslational modification] 1037911013719 intermolecular recognition site; other site 1037911013720 dimerization interface [polypeptide binding]; other site 1037911013721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911013722 Walker A motif; other site 1037911013723 ATP binding site [chemical binding]; other site 1037911013724 Walker B motif; other site 1037911013725 arginine finger; other site 1037911013726 poly(A) polymerase; Region: pcnB; TIGR01942 1037911013727 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1037911013728 active site 1037911013729 NTP binding site [chemical binding]; other site 1037911013730 metal binding triad [ion binding]; metal-binding site 1037911013731 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1037911013732 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1037911013733 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1037911013734 catalytic center binding site [active] 1037911013735 ATP binding site [chemical binding]; other site 1037911013736 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1037911013737 oligomerization interface [polypeptide binding]; other site 1037911013738 active site 1037911013739 metal binding site [ion binding]; metal-binding site 1037911013740 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1037911013741 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1037911013742 active site 1037911013743 ATP-binding site [chemical binding]; other site 1037911013744 pantoate-binding site; other site 1037911013745 HXXH motif; other site 1037911013746 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1037911013747 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1037911013748 active site 1037911013749 dimer interface [polypeptide binding]; other site 1037911013750 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1037911013751 dimer interface [polypeptide binding]; other site 1037911013752 active site 1037911013753 acetyl-CoA synthetase; Provisional; Region: PRK00174 1037911013754 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1037911013755 active site 1037911013756 CoA binding site [chemical binding]; other site 1037911013757 acyl-activating enzyme (AAE) consensus motif; other site 1037911013758 AMP binding site [chemical binding]; other site 1037911013759 acetate binding site [chemical binding]; other site 1037911013760 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1037911013761 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1037911013762 putative RNA binding site [nucleotide binding]; other site 1037911013763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911013764 S-adenosylmethionine binding site [chemical binding]; other site 1037911013765 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1037911013766 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1037911013767 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1037911013768 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1037911013769 BON domain; Region: BON; pfam04972 1037911013770 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1037911013771 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1037911013772 RNase E interface [polypeptide binding]; other site 1037911013773 trimer interface [polypeptide binding]; other site 1037911013774 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1037911013775 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1037911013776 RNase E interface [polypeptide binding]; other site 1037911013777 trimer interface [polypeptide binding]; other site 1037911013778 active site 1037911013779 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1037911013780 putative nucleic acid binding region [nucleotide binding]; other site 1037911013781 G-X-X-G motif; other site 1037911013782 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1037911013783 RNA binding site [nucleotide binding]; other site 1037911013784 domain interface; other site 1037911013785 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1037911013786 16S/18S rRNA binding site [nucleotide binding]; other site 1037911013787 S13e-L30e interaction site [polypeptide binding]; other site 1037911013788 25S rRNA binding site [nucleotide binding]; other site 1037911013789 Ribosomal S15 leader; Rfam score 41.02 1037911013790 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1037911013791 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1037911013792 RNA binding site [nucleotide binding]; other site 1037911013793 active site 1037911013794 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1037911013795 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1037911013796 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1037911013797 translation initiation factor IF-2; Region: IF-2; TIGR00487 1037911013798 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1037911013799 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1037911013800 G1 box; other site 1037911013801 putative GEF interaction site [polypeptide binding]; other site 1037911013802 GTP/Mg2+ binding site [chemical binding]; other site 1037911013803 Switch I region; other site 1037911013804 G2 box; other site 1037911013805 G3 box; other site 1037911013806 Switch II region; other site 1037911013807 G4 box; other site 1037911013808 G5 box; other site 1037911013809 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1037911013810 Translation-initiation factor 2; Region: IF-2; pfam11987 1037911013811 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1037911013812 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1037911013813 NusA N-terminal domain; Region: NusA_N; pfam08529 1037911013814 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1037911013815 RNA binding site [nucleotide binding]; other site 1037911013816 homodimer interface [polypeptide binding]; other site 1037911013817 NusA-like KH domain; Region: KH_5; pfam13184 1037911013818 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1037911013819 G-X-X-G motif; other site 1037911013820 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1037911013821 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1037911013822 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1037911013823 Sm and related proteins; Region: Sm_like; cl00259 1037911013824 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1037911013825 putative oligomer interface [polypeptide binding]; other site 1037911013826 putative RNA binding site [nucleotide binding]; other site 1037911013827 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1037911013828 triosephosphate isomerase; Provisional; Region: PRK14567 1037911013829 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1037911013830 substrate binding site [chemical binding]; other site 1037911013831 dimer interface [polypeptide binding]; other site 1037911013832 catalytic triad [active] 1037911013833 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1037911013834 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1037911013835 active site 1037911013836 substrate binding site [chemical binding]; other site 1037911013837 metal binding site [ion binding]; metal-binding site 1037911013838 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1037911013839 dihydropteroate synthase; Region: DHPS; TIGR01496 1037911013840 substrate binding pocket [chemical binding]; other site 1037911013841 dimer interface [polypeptide binding]; other site 1037911013842 inhibitor binding site; inhibition site 1037911013843 FtsH Extracellular; Region: FtsH_ext; pfam06480 1037911013844 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1037911013845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911013846 Walker A motif; other site 1037911013847 ATP binding site [chemical binding]; other site 1037911013848 Walker B motif; other site 1037911013849 arginine finger; other site 1037911013850 Peptidase family M41; Region: Peptidase_M41; pfam01434 1037911013851 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1037911013852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911013853 S-adenosylmethionine binding site [chemical binding]; other site 1037911013854 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1037911013855 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1037911013856 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1037911013857 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1037911013858 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1037911013859 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1037911013860 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1037911013861 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1037911013862 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1037911013863 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1037911013864 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1037911013865 IMP binding site; other site 1037911013866 dimer interface [polypeptide binding]; other site 1037911013867 interdomain contacts; other site 1037911013868 partial ornithine binding site; other site 1037911013869 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1037911013870 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1037911013871 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1037911013872 catalytic site [active] 1037911013873 subunit interface [polypeptide binding]; other site 1037911013874 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1037911013875 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1037911013876 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1037911013877 chaperone protein DnaJ; Provisional; Region: PRK10767 1037911013878 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1037911013879 HSP70 interaction site [polypeptide binding]; other site 1037911013880 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1037911013881 substrate binding site [polypeptide binding]; other site 1037911013882 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1037911013883 Zn binding sites [ion binding]; other site 1037911013884 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1037911013885 dimer interface [polypeptide binding]; other site 1037911013886 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1037911013887 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1037911013888 nucleotide binding site [chemical binding]; other site 1037911013889 GrpE; Region: GrpE; pfam01025 1037911013890 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1037911013891 dimer interface [polypeptide binding]; other site 1037911013892 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1037911013893 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1037911013894 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1037911013895 Walker A/P-loop; other site 1037911013896 ATP binding site [chemical binding]; other site 1037911013897 Q-loop/lid; other site 1037911013898 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1037911013899 Q-loop/lid; other site 1037911013900 ABC transporter signature motif; other site 1037911013901 Walker B; other site 1037911013902 D-loop; other site 1037911013903 H-loop/switch region; other site 1037911013904 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1037911013905 metal binding site 2 [ion binding]; metal-binding site 1037911013906 putative DNA binding helix; other site 1037911013907 metal binding site 1 [ion binding]; metal-binding site 1037911013908 dimer interface [polypeptide binding]; other site 1037911013909 structural Zn2+ binding site [ion binding]; other site 1037911013910 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1037911013911 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1037911013912 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1037911013913 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 1037911013914 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1037911013915 putative coenzyme Q binding site [chemical binding]; other site 1037911013916 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1037911013917 SmpB-tmRNA interface; other site 1037911013918 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911013919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911013920 DNA-binding site [nucleotide binding]; DNA binding site 1037911013921 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1037911013922 glycolate transporter; Provisional; Region: PRK09695 1037911013923 L-lactate permease; Region: Lactate_perm; cl00701 1037911013924 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1037911013925 FAD binding domain; Region: FAD_binding_4; pfam01565 1037911013926 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1037911013927 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1037911013928 integrase; Provisional; Region: PRK09692 1037911013929 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1037911013930 active site 1037911013931 Int/Topo IB signature motif; other site 1037911013932 Integrase; Region: Integrase_1; pfam12835 1037911013933 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1037911013934 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1037911013935 nucleotide binding site [chemical binding]; other site 1037911013936 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1037911013937 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1037911013938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911013939 ATP binding site [chemical binding]; other site 1037911013940 putative Mg++ binding site [ion binding]; other site 1037911013941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911013942 nucleotide binding region [chemical binding]; other site 1037911013943 ATP-binding site [chemical binding]; other site 1037911013944 DGQHR domain; Region: DGQHR; TIGR03187 1037911013945 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 1037911013946 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1037911013947 DNA methylase; Region: N6_N4_Mtase; pfam01555 1037911013948 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1037911013949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911013950 DNA binding residues [nucleotide binding] 1037911013951 dimerization interface [polypeptide binding]; other site 1037911013952 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1037911013953 FAD binding domain; Region: FAD_binding_4; pfam01565 1037911013954 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1037911013955 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1037911013956 active site 1037911013957 NAD binding site [chemical binding]; other site 1037911013958 metal binding site [ion binding]; metal-binding site 1037911013959 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1037911013960 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1037911013961 nucleotide binding site [chemical binding]; other site 1037911013962 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1037911013963 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1037911013964 inhibitor-cofactor binding pocket; inhibition site 1037911013965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911013966 catalytic residue [active] 1037911013967 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1037911013968 NAD(P) binding site [chemical binding]; other site 1037911013969 LDH/MDH dimer interface [polypeptide binding]; other site 1037911013970 substrate binding site [chemical binding]; other site 1037911013971 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1037911013972 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1037911013973 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1037911013974 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1037911013975 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1037911013976 putative active site [active] 1037911013977 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1037911013978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911013979 motif II; other site 1037911013980 Cupin domain; Region: Cupin_2; cl17218 1037911013981 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1037911013982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911013983 S-adenosylmethionine binding site [chemical binding]; other site 1037911013984 Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018 1037911013985 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1037911013986 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1037911013987 nudix motif; other site 1037911013988 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1037911013989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911013990 Coenzyme A binding pocket [chemical binding]; other site 1037911013991 Phosphotransferase enzyme family; Region: APH; pfam01636 1037911013992 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1037911013993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911013994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911013995 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1037911013996 dimerization interface [polypeptide binding]; other site 1037911013997 substrate binding pocket [chemical binding]; other site 1037911013998 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911013999 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1037911014000 catalytic triad [active] 1037911014001 conserved cis-peptide bond; other site 1037911014002 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1037911014003 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1037911014004 hypothetical protein; Provisional; Region: PRK05208 1037911014005 AAA domain; Region: AAA_32; pfam13654 1037911014006 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1037911014007 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1037911014008 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1037911014009 transcription elongation factor regulatory protein; Validated; Region: PRK06342 1037911014010 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1037911014011 glutamate dehydrogenase; Provisional; Region: PRK09414 1037911014012 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1037911014013 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1037911014014 NAD(P) binding site [chemical binding]; other site 1037911014015 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1037911014016 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1037911014017 tetramer interface [polypeptide binding]; other site 1037911014018 active site 1037911014019 Mg2+/Mn2+ binding site [ion binding]; other site 1037911014020 aspartate aminotransferase; Provisional; Region: PRK05764 1037911014021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911014022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911014023 homodimer interface [polypeptide binding]; other site 1037911014024 catalytic residue [active] 1037911014025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911014026 putative substrate translocation pore; other site 1037911014027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911014028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911014029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911014030 putative substrate translocation pore; other site 1037911014031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911014032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911014033 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1037911014034 dimerization interface [polypeptide binding]; other site 1037911014035 substrate binding pocket [chemical binding]; other site 1037911014036 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1037911014037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911014038 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911014039 ABC transporter; Region: ABC_tran_2; pfam12848 1037911014040 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911014041 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1037911014042 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1037911014043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911014044 PAS domain; Region: PAS_9; pfam13426 1037911014045 putative active site [active] 1037911014046 heme pocket [chemical binding]; other site 1037911014047 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911014048 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911014049 metal binding site [ion binding]; metal-binding site 1037911014050 active site 1037911014051 I-site; other site 1037911014052 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911014053 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1037911014054 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1037911014055 dimer interface [polypeptide binding]; other site 1037911014056 active site 1037911014057 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1037911014058 folate binding site [chemical binding]; other site 1037911014059 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1037911014060 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1037911014061 P-loop, Walker A motif; other site 1037911014062 Base recognition motif; other site 1037911014063 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1037911014064 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1037911014065 carbon starvation protein A; Provisional; Region: PRK15015 1037911014066 Carbon starvation protein CstA; Region: CstA; pfam02554 1037911014067 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1037911014068 PilZ domain; Region: PilZ; pfam07238 1037911014069 DNA repair protein RadA; Provisional; Region: PRK11823 1037911014070 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1037911014071 Walker A motif/ATP binding site; other site 1037911014072 ATP binding site [chemical binding]; other site 1037911014073 Walker B motif; other site 1037911014074 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1037911014075 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1037911014076 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1037911014077 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1037911014078 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1037911014079 tetramer interface [polypeptide binding]; other site 1037911014080 heme binding pocket [chemical binding]; other site 1037911014081 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1037911014082 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1037911014083 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1037911014084 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1037911014085 FAD binding pocket [chemical binding]; other site 1037911014086 FAD binding motif [chemical binding]; other site 1037911014087 phosphate binding motif [ion binding]; other site 1037911014088 beta-alpha-beta structure motif; other site 1037911014089 NAD binding pocket [chemical binding]; other site 1037911014090 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1037911014091 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1037911014092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1037911014093 DNA binding residues [nucleotide binding] 1037911014094 dimerization interface [polypeptide binding]; other site 1037911014095 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1037911014096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911014097 S-adenosylmethionine binding site [chemical binding]; other site 1037911014098 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1037911014099 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1037911014100 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1037911014101 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1037911014102 H+ Antiporter protein; Region: 2A0121; TIGR00900 1037911014103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911014104 putative substrate translocation pore; other site 1037911014105 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1037911014106 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1037911014107 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1037911014108 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1037911014109 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1037911014110 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1037911014111 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1037911014112 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1037911014113 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1037911014114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911014115 S-adenosylmethionine binding site [chemical binding]; other site 1037911014116 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1037911014117 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1037911014118 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1037911014119 active site 1037911014120 trimer interface [polypeptide binding]; other site 1037911014121 dimer interface [polypeptide binding]; other site 1037911014122 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1037911014123 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1037911014124 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1037911014125 shikimate binding site; other site 1037911014126 NAD(P) binding site [chemical binding]; other site 1037911014127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911014128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911014129 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1037911014130 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1037911014131 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1037911014132 dimer interface [polypeptide binding]; other site 1037911014133 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1037911014134 active site 1037911014135 Fe binding site [ion binding]; other site 1037911014136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911014137 D-galactonate transporter; Region: 2A0114; TIGR00893 1037911014138 putative substrate translocation pore; other site 1037911014139 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1037911014140 EamA-like transporter family; Region: EamA; pfam00892 1037911014141 Predicted metalloprotease [General function prediction only]; Region: COG2321 1037911014142 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1037911014143 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1037911014144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911014145 active site 1037911014146 motif I; other site 1037911014147 motif II; other site 1037911014148 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1037911014149 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1037911014150 active site 1037911014151 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1037911014152 catalytic triad [active] 1037911014153 dimer interface [polypeptide binding]; other site 1037911014154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1037911014155 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1037911014156 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1037911014157 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1037911014158 putative active site [active] 1037911014159 Zn binding site [ion binding]; other site 1037911014160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1037911014161 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1037911014162 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1037911014163 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1037911014164 ATP binding site [chemical binding]; other site 1037911014165 Mg++ binding site [ion binding]; other site 1037911014166 motif III; other site 1037911014167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911014168 nucleotide binding region [chemical binding]; other site 1037911014169 ATP-binding site [chemical binding]; other site 1037911014170 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1037911014171 EamA-like transporter family; Region: EamA; pfam00892 1037911014172 EamA-like transporter family; Region: EamA; pfam00892 1037911014173 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1037911014174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911014175 putative DNA binding site [nucleotide binding]; other site 1037911014176 putative Zn2+ binding site [ion binding]; other site 1037911014177 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911014178 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1037911014179 active site 1037911014180 catalytic site [active] 1037911014181 substrate binding site [chemical binding]; other site 1037911014182 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1037911014183 LabA_like proteins; Region: LabA; cd10911 1037911014184 putative metal binding site [ion binding]; other site 1037911014185 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1037911014186 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 1037911014187 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1037911014188 putative catalytic site [active] 1037911014189 putative metal binding site [ion binding]; other site 1037911014190 putative phosphate binding site [ion binding]; other site 1037911014191 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1037911014192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911014193 ATP binding site [chemical binding]; other site 1037911014194 putative Mg++ binding site [ion binding]; other site 1037911014195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911014196 nucleotide binding region [chemical binding]; other site 1037911014197 ATP-binding site [chemical binding]; other site 1037911014198 Helicase associated domain (HA2); Region: HA2; pfam04408 1037911014199 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1037911014200 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1037911014201 Cation efflux family; Region: Cation_efflux; cl00316 1037911014202 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 1037911014203 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1037911014204 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911014205 putative DNA binding site [nucleotide binding]; other site 1037911014206 putative Zn2+ binding site [ion binding]; other site 1037911014207 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911014208 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1037911014209 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1037911014210 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1037911014211 active site 1037911014212 AMP nucleosidase; Provisional; Region: PRK08292 1037911014213 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1037911014214 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1037911014215 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1037911014216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911014217 active site 1037911014218 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1037911014219 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1037911014220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1037911014221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911014222 dimer interface [polypeptide binding]; other site 1037911014223 phosphorylation site [posttranslational modification] 1037911014224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911014225 ATP binding site [chemical binding]; other site 1037911014226 Mg2+ binding site [ion binding]; other site 1037911014227 G-X-G motif; other site 1037911014228 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911014229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911014230 active site 1037911014231 phosphorylation site [posttranslational modification] 1037911014232 intermolecular recognition site; other site 1037911014233 dimerization interface [polypeptide binding]; other site 1037911014234 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1037911014235 dimer interface [polypeptide binding]; other site 1037911014236 substrate binding site [chemical binding]; other site 1037911014237 ATP binding site [chemical binding]; other site 1037911014238 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1037911014239 thiamine phosphate binding site [chemical binding]; other site 1037911014240 active site 1037911014241 pyrophosphate binding site [ion binding]; other site 1037911014242 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1037911014243 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911014244 inhibitor-cofactor binding pocket; inhibition site 1037911014245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911014246 catalytic residue [active] 1037911014247 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1037911014248 Sel1-like repeats; Region: SEL1; smart00671 1037911014249 Sel1-like repeats; Region: SEL1; smart00671 1037911014250 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1037911014251 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1037911014252 active site 1037911014253 Zn binding site [ion binding]; other site 1037911014254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911014255 dimer interface [polypeptide binding]; other site 1037911014256 conserved gate region; other site 1037911014257 putative PBP binding loops; other site 1037911014258 ABC-ATPase subunit interface; other site 1037911014259 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911014260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911014261 dimer interface [polypeptide binding]; other site 1037911014262 conserved gate region; other site 1037911014263 putative PBP binding loops; other site 1037911014264 ABC-ATPase subunit interface; other site 1037911014265 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1037911014266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911014267 substrate binding pocket [chemical binding]; other site 1037911014268 membrane-bound complex binding site; other site 1037911014269 hinge residues; other site 1037911014270 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 1037911014271 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1037911014272 FMN binding site [chemical binding]; other site 1037911014273 active site 1037911014274 homodimer interface [polypeptide binding]; other site 1037911014275 putative catalytic residue [active] 1037911014276 4Fe-4S cluster binding site [ion binding]; other site 1037911014277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911014278 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1037911014279 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1037911014280 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1037911014281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911014282 FeS/SAM binding site; other site 1037911014283 TRAM domain; Region: TRAM; pfam01938 1037911014284 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1037911014285 PhoH-like protein; Region: PhoH; pfam02562 1037911014286 metal-binding heat shock protein; Provisional; Region: PRK00016 1037911014287 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1037911014288 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1037911014289 Transporter associated domain; Region: CorC_HlyC; smart01091 1037911014290 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1037911014291 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1037911014292 putative active site [active] 1037911014293 catalytic triad [active] 1037911014294 putative dimer interface [polypeptide binding]; other site 1037911014295 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1037911014296 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1037911014297 putative active site [active] 1037911014298 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1037911014299 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1037911014300 HIGH motif; other site 1037911014301 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1037911014302 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1037911014303 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1037911014304 active site 1037911014305 KMSKS motif; other site 1037911014306 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1037911014307 tRNA binding surface [nucleotide binding]; other site 1037911014308 Lipopolysaccharide-assembly; Region: LptE; cl01125 1037911014309 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1037911014310 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1037911014311 Domain of unknown function; Region: DUF331; cl01149 1037911014312 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1037911014313 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1037911014314 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1037911014315 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1037911014316 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1037911014317 dimer interface [polypeptide binding]; other site 1037911014318 catalytic triad [active] 1037911014319 lipoyl synthase; Provisional; Region: PRK05481 1037911014320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911014321 FeS/SAM binding site; other site 1037911014322 lipoate-protein ligase B; Provisional; Region: PRK14342 1037911014323 Protein of unknown function (DUF493); Region: DUF493; cl01102 1037911014324 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1037911014325 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1037911014326 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1037911014327 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1037911014328 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1037911014329 Sporulation related domain; Region: SPOR; pfam05036 1037911014330 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1037911014331 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1037911014332 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1037911014333 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1037911014334 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1037911014335 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1037911014336 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1037911014337 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1037911014338 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1037911014339 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1037911014340 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1037911014341 active site 1037911014342 (T/H)XGH motif; other site 1037911014343 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1037911014344 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1037911014345 putative catalytic cysteine [active] 1037911014346 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1037911014347 active site 1037911014348 DNA binding site [nucleotide binding] 1037911014349 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1037911014350 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1037911014351 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1037911014352 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1037911014353 active site 1037911014354 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1037911014355 LrgB-like family; Region: LrgB; pfam04172 1037911014356 LrgA family; Region: LrgA; cl00608 1037911014357 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1037911014358 putative active site [active] 1037911014359 putative catalytic site [active] 1037911014360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1037911014361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1037911014362 Peptidase C13 family; Region: Peptidase_C13; cl02159 1037911014363 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1037911014364 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1037911014365 NAD binding site [chemical binding]; other site 1037911014366 active site 1037911014367 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 1037911014368 aromatic acid decarboxylase; Validated; Region: PRK05920 1037911014369 Flavoprotein; Region: Flavoprotein; pfam02441 1037911014370 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1037911014371 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1037911014372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1037911014373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1037911014374 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1037911014375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911014376 Walker A motif; other site 1037911014377 ATP binding site [chemical binding]; other site 1037911014378 Walker B motif; other site 1037911014379 arginine finger; other site 1037911014380 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1037911014381 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1037911014382 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1037911014383 NAD(P) binding site [chemical binding]; other site 1037911014384 catalytic residues [active] 1037911014385 ethanolamine permease; Region: 2A0305; TIGR00908 1037911014386 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1037911014387 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1037911014388 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1037911014389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911014390 Coenzyme A binding pocket [chemical binding]; other site 1037911014391 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1037911014392 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1037911014393 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1037911014394 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1037911014395 dimer interface [polypeptide binding]; other site 1037911014396 substrate binding site [chemical binding]; other site 1037911014397 metal binding sites [ion binding]; metal-binding site 1037911014398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911014399 non-specific DNA binding site [nucleotide binding]; other site 1037911014400 salt bridge; other site 1037911014401 sequence-specific DNA binding site [nucleotide binding]; other site 1037911014402 Predicted transcriptional regulator [Transcription]; Region: COG2932 1037911014403 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1037911014404 Catalytic site [active] 1037911014405 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911014406 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1037911014407 catalytic triad [active] 1037911014408 dimer interface [polypeptide binding]; other site 1037911014409 conserved cis-peptide bond; other site 1037911014410 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1037911014411 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 1037911014412 Predicted membrane protein [Function unknown]; Region: COG3766 1037911014413 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1037911014414 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1037911014415 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1037911014416 Ion channel; Region: Ion_trans_2; pfam07885 1037911014417 TrkA-N domain; Region: TrkA_N; pfam02254 1037911014418 Rhomboid family; Region: Rhomboid; pfam01694 1037911014419 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1037911014420 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 1037911014421 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1037911014422 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1037911014423 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1037911014424 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1037911014425 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1037911014426 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1037911014427 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1037911014428 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1037911014429 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1037911014430 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1037911014431 substrate binding pocket [chemical binding]; other site 1037911014432 chain length determination region; other site 1037911014433 substrate-Mg2+ binding site; other site 1037911014434 catalytic residues [active] 1037911014435 aspartate-rich region 1; other site 1037911014436 active site lid residues [active] 1037911014437 aspartate-rich region 2; other site 1037911014438 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1037911014439 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1037911014440 TPP-binding site; other site 1037911014441 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1037911014442 PYR/PP interface [polypeptide binding]; other site 1037911014443 dimer interface [polypeptide binding]; other site 1037911014444 TPP binding site [chemical binding]; other site 1037911014445 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1037911014446 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1037911014447 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911014448 N-terminal plug; other site 1037911014449 ligand-binding site [chemical binding]; other site 1037911014450 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1037911014451 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1037911014452 cobalamin binding residues [chemical binding]; other site 1037911014453 putative BtuC binding residues; other site 1037911014454 dimer interface [polypeptide binding]; other site 1037911014455 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1037911014456 dimerization interface [polypeptide binding]; other site 1037911014457 active site 1037911014458 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911014459 conserved hypothetical protein; Region: TIGR02285 1037911014460 thiamine monophosphate kinase; Provisional; Region: PRK05731 1037911014461 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1037911014462 ATP binding site [chemical binding]; other site 1037911014463 dimerization interface [polypeptide binding]; other site 1037911014464 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1037911014465 putative RNA binding site [nucleotide binding]; other site 1037911014466 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1037911014467 homopentamer interface [polypeptide binding]; other site 1037911014468 active site 1037911014469 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1037911014470 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1037911014471 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1037911014472 dimerization interface [polypeptide binding]; other site 1037911014473 active site 1037911014474 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1037911014475 Lumazine binding domain; Region: Lum_binding; pfam00677 1037911014476 Lumazine binding domain; Region: Lum_binding; pfam00677 1037911014477 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1037911014478 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1037911014479 catalytic motif [active] 1037911014480 Zn binding site [ion binding]; other site 1037911014481 RibD C-terminal domain; Region: RibD_C; cl17279 1037911014482 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1037911014483 ATP cone domain; Region: ATP-cone; pfam03477 1037911014484 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1037911014485 Predicted methyltransferase [General function prediction only]; Region: COG3897 1037911014486 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1037911014487 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1037911014488 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1037911014489 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1037911014490 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1037911014491 Walker A/P-loop; other site 1037911014492 ATP binding site [chemical binding]; other site 1037911014493 Q-loop/lid; other site 1037911014494 ABC transporter signature motif; other site 1037911014495 Walker B; other site 1037911014496 D-loop; other site 1037911014497 H-loop/switch region; other site 1037911014498 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1037911014499 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1037911014500 FtsX-like permease family; Region: FtsX; pfam02687 1037911014501 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1037911014502 OmpW family; Region: OmpW; cl17427 1037911014503 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1037911014504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1037911014505 NAD(P) binding site [chemical binding]; other site 1037911014506 active site 1037911014507 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1037911014508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911014509 ATP binding site [chemical binding]; other site 1037911014510 putative Mg++ binding site [ion binding]; other site 1037911014511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911014512 nucleotide binding region [chemical binding]; other site 1037911014513 ATP-binding site [chemical binding]; other site 1037911014514 DEAD/H associated; Region: DEAD_assoc; pfam08494 1037911014515 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1037911014516 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1037911014517 Protein of unknown function DUF72; Region: DUF72; pfam01904 1037911014518 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1037911014519 putative catalytic site [active] 1037911014520 putative metal binding site [ion binding]; other site 1037911014521 putative phosphate binding site [ion binding]; other site 1037911014522 putative catalytic site [active] 1037911014523 putative phosphate binding site [ion binding]; other site 1037911014524 putative metal binding site [ion binding]; other site 1037911014525 cardiolipin synthase 2; Provisional; Region: PRK11263 1037911014526 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1037911014527 putative active site [active] 1037911014528 catalytic site [active] 1037911014529 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1037911014530 putative active site [active] 1037911014531 catalytic site [active] 1037911014532 Predicted integral membrane protein [Function unknown]; Region: COG0392 1037911014533 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1037911014534 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1037911014535 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1037911014536 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911014537 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1037911014538 conserved cys residue [active] 1037911014539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911014540 Isochorismatase family; Region: Isochorismatase; pfam00857 1037911014541 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1037911014542 catalytic triad [active] 1037911014543 conserved cis-peptide bond; other site 1037911014544 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1037911014545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911014546 S-adenosylmethionine binding site [chemical binding]; other site 1037911014547 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1037911014548 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1037911014549 dimer interface [polypeptide binding]; other site 1037911014550 ssDNA binding site [nucleotide binding]; other site 1037911014551 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1037911014552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911014553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911014554 putative substrate translocation pore; other site 1037911014555 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1037911014556 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1037911014557 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1037911014558 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1037911014559 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1037911014560 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1037911014561 heme binding site [chemical binding]; other site 1037911014562 ferroxidase pore; other site 1037911014563 ferroxidase diiron center [ion binding]; other site 1037911014564 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1037911014565 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1037911014566 tetramer interface [polypeptide binding]; other site 1037911014567 heme binding pocket [chemical binding]; other site 1037911014568 NADPH binding site [chemical binding]; other site 1037911014569 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1037911014570 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1037911014571 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1037911014572 alphaNTD homodimer interface [polypeptide binding]; other site 1037911014573 alphaNTD - beta interaction site [polypeptide binding]; other site 1037911014574 alphaNTD - beta' interaction site [polypeptide binding]; other site 1037911014575 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1037911014576 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1037911014577 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1037911014578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1037911014579 RNA binding surface [nucleotide binding]; other site 1037911014580 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1037911014581 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1037911014582 SecY translocase; Region: SecY; pfam00344 1037911014583 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1037911014584 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1037911014585 23S rRNA binding site [nucleotide binding]; other site 1037911014586 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1037911014587 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1037911014588 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1037911014589 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1037911014590 5S rRNA interface [nucleotide binding]; other site 1037911014591 23S rRNA interface [nucleotide binding]; other site 1037911014592 L5 interface [polypeptide binding]; other site 1037911014593 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1037911014594 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1037911014595 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1037911014596 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1037911014597 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1037911014598 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1037911014599 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1037911014600 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1037911014601 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1037911014602 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1037911014603 RNA binding site [nucleotide binding]; other site 1037911014604 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1037911014605 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1037911014606 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1037911014607 23S rRNA interface [nucleotide binding]; other site 1037911014608 putative translocon interaction site; other site 1037911014609 signal recognition particle (SRP54) interaction site; other site 1037911014610 L23 interface [polypeptide binding]; other site 1037911014611 trigger factor interaction site; other site 1037911014612 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1037911014613 23S rRNA interface [nucleotide binding]; other site 1037911014614 5S rRNA interface [nucleotide binding]; other site 1037911014615 putative antibiotic binding site [chemical binding]; other site 1037911014616 L25 interface [polypeptide binding]; other site 1037911014617 L27 interface [polypeptide binding]; other site 1037911014618 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1037911014619 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1037911014620 G-X-X-G motif; other site 1037911014621 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1037911014622 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1037911014623 protein-rRNA interface [nucleotide binding]; other site 1037911014624 putative translocon binding site; other site 1037911014625 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1037911014626 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1037911014627 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1037911014628 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1037911014629 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1037911014630 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1037911014631 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1037911014632 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1037911014633 elongation factor Tu; Reviewed; Region: PRK00049 1037911014634 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1037911014635 G1 box; other site 1037911014636 GEF interaction site [polypeptide binding]; other site 1037911014637 GTP/Mg2+ binding site [chemical binding]; other site 1037911014638 Switch I region; other site 1037911014639 G2 box; other site 1037911014640 G3 box; other site 1037911014641 Switch II region; other site 1037911014642 G4 box; other site 1037911014643 G5 box; other site 1037911014644 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1037911014645 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1037911014646 Antibiotic Binding Site [chemical binding]; other site 1037911014647 elongation factor G; Reviewed; Region: PRK00007 1037911014648 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1037911014649 G1 box; other site 1037911014650 putative GEF interaction site [polypeptide binding]; other site 1037911014651 GTP/Mg2+ binding site [chemical binding]; other site 1037911014652 Switch I region; other site 1037911014653 G2 box; other site 1037911014654 G3 box; other site 1037911014655 Switch II region; other site 1037911014656 G4 box; other site 1037911014657 G5 box; other site 1037911014658 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1037911014659 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1037911014660 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1037911014661 30S ribosomal protein S7; Validated; Region: PRK05302 1037911014662 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1037911014663 S17 interaction site [polypeptide binding]; other site 1037911014664 S8 interaction site; other site 1037911014665 16S rRNA interaction site [nucleotide binding]; other site 1037911014666 streptomycin interaction site [chemical binding]; other site 1037911014667 23S rRNA interaction site [nucleotide binding]; other site 1037911014668 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1037911014669 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1037911014670 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1037911014671 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1037911014672 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1037911014673 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1037911014674 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1037911014675 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1037911014676 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1037911014677 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1037911014678 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1037911014679 DNA binding site [nucleotide binding] 1037911014680 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1037911014681 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1037911014682 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1037911014683 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1037911014684 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1037911014685 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1037911014686 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1037911014687 RPB3 interaction site [polypeptide binding]; other site 1037911014688 RPB1 interaction site [polypeptide binding]; other site 1037911014689 RPB11 interaction site [polypeptide binding]; other site 1037911014690 RPB10 interaction site [polypeptide binding]; other site 1037911014691 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1037911014692 peripheral dimer interface [polypeptide binding]; other site 1037911014693 core dimer interface [polypeptide binding]; other site 1037911014694 L10 interface [polypeptide binding]; other site 1037911014695 L11 interface [polypeptide binding]; other site 1037911014696 putative EF-Tu interaction site [polypeptide binding]; other site 1037911014697 putative EF-G interaction site [polypeptide binding]; other site 1037911014698 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1037911014699 23S rRNA interface [nucleotide binding]; other site 1037911014700 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1037911014701 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1037911014702 mRNA/rRNA interface [nucleotide binding]; other site 1037911014703 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1037911014704 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1037911014705 23S rRNA interface [nucleotide binding]; other site 1037911014706 L7/L12 interface [polypeptide binding]; other site 1037911014707 putative thiostrepton binding site; other site 1037911014708 L25 interface [polypeptide binding]; other site 1037911014709 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1037911014710 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1037911014711 putative homodimer interface [polypeptide binding]; other site 1037911014712 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1037911014713 heterodimer interface [polypeptide binding]; other site 1037911014714 homodimer interface [polypeptide binding]; other site 1037911014715 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1037911014716 pantothenate kinase; Reviewed; Region: PRK13322 1037911014717 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1037911014718 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1037911014719 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1037911014720 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1037911014721 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1037911014722 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1037911014723 active site 1037911014724 HIGH motif; other site 1037911014725 dimer interface [polypeptide binding]; other site 1037911014726 KMSKS motif; other site 1037911014727 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1037911014728 Peptidase family M23; Region: Peptidase_M23; pfam01551 1037911014729 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1037911014730 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1037911014731 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1037911014732 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1037911014733 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1037911014734 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1037911014735 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1037911014736 FMN binding site [chemical binding]; other site 1037911014737 substrate binding site [chemical binding]; other site 1037911014738 putative catalytic residue [active] 1037911014739 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1037911014740 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1037911014741 classical (c) SDRs; Region: SDR_c; cd05233 1037911014742 NAD(P) binding site [chemical binding]; other site 1037911014743 active site 1037911014744 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1037911014745 nucleotide binding site/active site [active] 1037911014746 HIT family signature motif; other site 1037911014747 catalytic residue [active] 1037911014748 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1037911014749 diiron binding motif [ion binding]; other site 1037911014750 OsmC-like protein; Region: OsmC; cl00767 1037911014751 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1037911014752 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1037911014753 ligand binding site [chemical binding]; other site 1037911014754 flexible hinge region; other site 1037911014755 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1037911014756 putative switch regulator; other site 1037911014757 non-specific DNA interactions [nucleotide binding]; other site 1037911014758 DNA binding site [nucleotide binding] 1037911014759 sequence specific DNA binding site [nucleotide binding]; other site 1037911014760 putative cAMP binding site [chemical binding]; other site 1037911014761 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1037911014762 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1037911014763 active site 1037911014764 ribulose/triose binding site [chemical binding]; other site 1037911014765 phosphate binding site [ion binding]; other site 1037911014766 substrate (anthranilate) binding pocket [chemical binding]; other site 1037911014767 product (indole) binding pocket [chemical binding]; other site 1037911014768 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1037911014769 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1037911014770 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1037911014771 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1037911014772 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1037911014773 glutamine binding [chemical binding]; other site 1037911014774 catalytic triad [active] 1037911014775 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1037911014776 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1037911014777 active site 1037911014778 catalytic triad [active] 1037911014779 oxyanion hole [active] 1037911014780 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1037911014781 anthranilate synthase component I; Provisional; Region: PRK13565 1037911014782 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1037911014783 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1037911014784 phosphoglycolate phosphatase; Provisional; Region: PRK13223 1037911014785 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1037911014786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911014787 motif II; other site 1037911014788 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1037911014789 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1037911014790 substrate binding site [chemical binding]; other site 1037911014791 hexamer interface [polypeptide binding]; other site 1037911014792 metal binding site [ion binding]; metal-binding site 1037911014793 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1037911014794 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1037911014795 active site 1037911014796 NAD binding site [chemical binding]; other site 1037911014797 metal binding site [ion binding]; metal-binding site 1037911014798 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1037911014799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911014800 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1037911014801 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1037911014802 putative metal binding site [ion binding]; other site 1037911014803 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1037911014804 HSP70 interaction site [polypeptide binding]; other site 1037911014805 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1037911014806 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1037911014807 Substrate binding site; other site 1037911014808 metal-binding site 1037911014809 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1037911014810 Phosphotransferase enzyme family; Region: APH; pfam01636 1037911014811 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1037911014812 OstA-like protein; Region: OstA; cl00844 1037911014813 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1037911014814 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1037911014815 SurA N-terminal domain; Region: SurA_N; pfam09312 1037911014816 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1037911014817 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1037911014818 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1037911014819 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1037911014820 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1037911014821 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1037911014822 S-adenosylmethionine binding site [chemical binding]; other site 1037911014823 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1037911014824 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1037911014825 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1037911014826 active site 1037911014827 metal binding site [ion binding]; metal-binding site 1037911014828 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1037911014829 active site residue [active] 1037911014830 PrkA family serine protein kinase; Provisional; Region: PRK15455 1037911014831 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1037911014832 hypothetical protein; Provisional; Region: PRK05325 1037911014833 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1037911014834 SpoVR family protein; Provisional; Region: PRK11767 1037911014835 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1037911014836 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1037911014837 active site 1037911014838 NTP binding site [chemical binding]; other site 1037911014839 metal binding triad [ion binding]; metal-binding site 1037911014840 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1037911014841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1037911014842 Zn2+ binding site [ion binding]; other site 1037911014843 Mg2+ binding site [ion binding]; other site 1037911014844 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1037911014845 catalytic center binding site [active] 1037911014846 ATP binding site [chemical binding]; other site 1037911014847 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1037911014848 homooctamer interface [polypeptide binding]; other site 1037911014849 active site 1037911014850 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1037911014851 UGMP family protein; Validated; Region: PRK09604 1037911014852 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1037911014853 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1037911014854 DNA primase; Validated; Region: dnaG; PRK05667 1037911014855 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1037911014856 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1037911014857 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1037911014858 active site 1037911014859 metal binding site [ion binding]; metal-binding site 1037911014860 interdomain interaction site; other site 1037911014861 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1037911014862 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1037911014863 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1037911014864 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1037911014865 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1037911014866 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1037911014867 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911014868 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1037911014869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911014870 DNA binding residues [nucleotide binding] 1037911014871 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911014872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911014873 substrate binding pocket [chemical binding]; other site 1037911014874 membrane-bound complex binding site; other site 1037911014875 hinge residues; other site 1037911014876 PAS domain S-box; Region: sensory_box; TIGR00229 1037911014877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911014878 putative active site [active] 1037911014879 heme pocket [chemical binding]; other site 1037911014880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911014881 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1037911014882 putative active site [active] 1037911014883 heme pocket [chemical binding]; other site 1037911014884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911014885 putative active site [active] 1037911014886 heme pocket [chemical binding]; other site 1037911014887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911014888 putative active site [active] 1037911014889 heme pocket [chemical binding]; other site 1037911014890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911014891 metal binding site [ion binding]; metal-binding site 1037911014892 active site 1037911014893 I-site; other site 1037911014894 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911014895 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1037911014896 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1037911014897 putative DNA binding site [nucleotide binding]; other site 1037911014898 putative Zn2+ binding site [ion binding]; other site 1037911014899 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911014900 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1037911014901 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1037911014902 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1037911014903 putative active site [active] 1037911014904 catalytic triad [active] 1037911014905 putative dimer interface [polypeptide binding]; other site 1037911014906 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1037911014907 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1037911014908 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1037911014909 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1037911014910 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1037911014911 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1037911014912 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1037911014913 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1037911014914 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1037911014915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911014916 FeS/SAM binding site; other site 1037911014917 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1037911014918 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1037911014919 Predicted transcriptional regulator [Transcription]; Region: COG2944 1037911014920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911014921 non-specific DNA binding site [nucleotide binding]; other site 1037911014922 salt bridge; other site 1037911014923 sequence-specific DNA binding site [nucleotide binding]; other site 1037911014924 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 1037911014925 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1037911014926 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911014927 inhibitor-cofactor binding pocket; inhibition site 1037911014928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911014929 catalytic residue [active] 1037911014930 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911014931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911014932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911014933 dimerization interface [polypeptide binding]; other site 1037911014934 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1037911014935 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1037911014936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911014937 active site 1037911014938 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1037911014939 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1037911014940 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1037911014941 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911014942 active site 1037911014943 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1037911014944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911014945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911014946 metal binding site [ion binding]; metal-binding site 1037911014947 active site 1037911014948 I-site; other site 1037911014949 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1037911014950 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1037911014951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1037911014952 active site 1037911014953 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1037911014954 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1037911014955 AAA domain; Region: AAA_26; pfam13500 1037911014956 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1037911014957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911014958 S-adenosylmethionine binding site [chemical binding]; other site 1037911014959 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1037911014960 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1037911014961 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1037911014962 substrate-cofactor binding pocket; other site 1037911014963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911014964 catalytic residue [active] 1037911014965 biotin synthase; Provisional; Region: PRK15108 1037911014966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911014967 FeS/SAM binding site; other site 1037911014968 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1037911014969 comF family protein; Region: comF; TIGR00201 1037911014970 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911014971 active site 1037911014972 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1037911014973 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1037911014974 TOBE domain; Region: TOBE; cl01440 1037911014975 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1037911014976 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1037911014977 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1037911014978 serine/threonine protein kinase; Provisional; Region: PRK11768 1037911014979 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1037911014980 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1037911014981 ACT domain; Region: ACT_6; pfam13740 1037911014982 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1037911014983 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1037911014984 active site 1037911014985 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1037911014986 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1037911014987 ligand binding site [chemical binding]; other site 1037911014988 flexible hinge region; other site 1037911014989 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1037911014990 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1037911014991 metal binding triad; other site 1037911014992 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1037911014993 active site 1037911014994 catalytic site [active] 1037911014995 substrate binding site [chemical binding]; other site 1037911014996 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1037911014997 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911014998 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911014999 DNA binding residues [nucleotide binding] 1037911015000 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1037911015001 FecR protein; Region: FecR; pfam04773 1037911015002 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911015003 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1037911015004 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911015005 N-terminal plug; other site 1037911015006 ligand-binding site [chemical binding]; other site 1037911015007 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1037911015008 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1037911015009 putative glutathione S-transferase; Provisional; Region: PRK10357 1037911015010 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1037911015011 putative C-terminal domain interface [polypeptide binding]; other site 1037911015012 putative GSH binding site (G-site) [chemical binding]; other site 1037911015013 putative dimer interface [polypeptide binding]; other site 1037911015014 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1037911015015 dimer interface [polypeptide binding]; other site 1037911015016 N-terminal domain interface [polypeptide binding]; other site 1037911015017 putative substrate binding pocket (H-site) [chemical binding]; other site 1037911015018 inner membrane protein; Provisional; Region: PRK11715 1037911015019 sensory histidine kinase CreC; Provisional; Region: PRK11100 1037911015020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911015021 dimer interface [polypeptide binding]; other site 1037911015022 phosphorylation site [posttranslational modification] 1037911015023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911015024 ATP binding site [chemical binding]; other site 1037911015025 Mg2+ binding site [ion binding]; other site 1037911015026 G-X-G motif; other site 1037911015027 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1037911015028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911015029 active site 1037911015030 phosphorylation site [posttranslational modification] 1037911015031 intermolecular recognition site; other site 1037911015032 dimerization interface [polypeptide binding]; other site 1037911015033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911015034 DNA binding site [nucleotide binding] 1037911015035 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1037911015036 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1037911015037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1037911015038 putative acyl-acceptor binding pocket; other site 1037911015039 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1037911015040 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1037911015041 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1037911015042 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1037911015043 NAD binding site [chemical binding]; other site 1037911015044 catalytic Zn binding site [ion binding]; other site 1037911015045 structural Zn binding site [ion binding]; other site 1037911015046 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1037911015047 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1037911015048 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1037911015049 putative active site [active] 1037911015050 putative substrate binding site [chemical binding]; other site 1037911015051 putative cosubstrate binding site; other site 1037911015052 catalytic site [active] 1037911015053 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 1037911015054 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1037911015055 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1037911015056 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1037911015057 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1037911015058 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1037911015059 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1037911015060 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1037911015061 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1037911015062 dimer interface [polypeptide binding]; other site 1037911015063 active site 1037911015064 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1037911015065 folate binding site [chemical binding]; other site 1037911015066 TraX protein; Region: TraX; cl05434 1037911015067 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1037911015068 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1037911015069 tetramer interface [polypeptide binding]; other site 1037911015070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911015071 catalytic residue [active] 1037911015072 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1037911015073 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1037911015074 FAD binding pocket [chemical binding]; other site 1037911015075 FAD binding motif [chemical binding]; other site 1037911015076 phosphate binding motif [ion binding]; other site 1037911015077 beta-alpha-beta structure motif; other site 1037911015078 NAD binding pocket [chemical binding]; other site 1037911015079 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911015080 catalytic loop [active] 1037911015081 iron binding site [ion binding]; other site 1037911015082 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1037911015083 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1037911015084 [2Fe-2S] cluster binding site [ion binding]; other site 1037911015085 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1037911015086 putative alpha subunit interface [polypeptide binding]; other site 1037911015087 putative active site [active] 1037911015088 putative substrate binding site [chemical binding]; other site 1037911015089 Fe binding site [ion binding]; other site 1037911015090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1037911015091 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1037911015092 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1037911015093 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1037911015094 Ligand Binding Site [chemical binding]; other site 1037911015095 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1037911015096 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1037911015097 Ligand binding site [chemical binding]; other site 1037911015098 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1037911015099 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1037911015100 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1037911015101 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1037911015102 Cysteine-rich domain; Region: CCG; pfam02754 1037911015103 Cysteine-rich domain; Region: CCG; pfam02754 1037911015104 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1037911015105 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1037911015106 putative active site [active] 1037911015107 putative FMN binding site [chemical binding]; other site 1037911015108 putative substrate binding site [chemical binding]; other site 1037911015109 putative catalytic residue [active] 1037911015110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911015111 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1037911015112 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1037911015113 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1037911015114 active site 1037911015115 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1037911015116 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 1037911015117 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 1037911015118 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1037911015119 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911015120 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1037911015121 conserved cys residue [active] 1037911015122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911015123 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1037911015124 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1037911015125 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1037911015126 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1037911015127 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1037911015128 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1037911015129 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1037911015130 active site 1037911015131 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911015132 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1037911015133 conserved cys residue [active] 1037911015134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911015135 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1037911015136 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1037911015137 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1037911015138 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1037911015139 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1037911015140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015141 dimer interface [polypeptide binding]; other site 1037911015142 conserved gate region; other site 1037911015143 putative PBP binding loops; other site 1037911015144 ABC-ATPase subunit interface; other site 1037911015145 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1037911015146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911015147 Walker A/P-loop; other site 1037911015148 ATP binding site [chemical binding]; other site 1037911015149 Q-loop/lid; other site 1037911015150 ABC transporter signature motif; other site 1037911015151 Walker B; other site 1037911015152 D-loop; other site 1037911015153 H-loop/switch region; other site 1037911015154 BCCT family transporter; Region: BCCT; cl00569 1037911015155 transcriptional regulator BetI; Validated; Region: PRK00767 1037911015156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911015157 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1037911015158 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1037911015159 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1037911015160 tetrameric interface [polypeptide binding]; other site 1037911015161 NAD binding site [chemical binding]; other site 1037911015162 catalytic residues [active] 1037911015163 choline dehydrogenase; Validated; Region: PRK02106 1037911015164 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1037911015165 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1037911015166 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1037911015167 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911015168 putative transporter; Provisional; Region: PRK10504 1037911015169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911015170 putative substrate translocation pore; other site 1037911015171 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1037911015172 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1037911015173 ATP binding site [chemical binding]; other site 1037911015174 Mg++ binding site [ion binding]; other site 1037911015175 motif III; other site 1037911015176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911015177 nucleotide binding region [chemical binding]; other site 1037911015178 ATP-binding site [chemical binding]; other site 1037911015179 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1037911015180 putative RNA binding site [nucleotide binding]; other site 1037911015181 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1037911015182 HI0933-like protein; Region: HI0933_like; pfam03486 1037911015183 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1037911015184 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1037911015185 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1037911015186 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911015187 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911015188 substrate binding pocket [chemical binding]; other site 1037911015189 membrane-bound complex binding site; other site 1037911015190 hinge residues; other site 1037911015191 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1037911015192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911015193 Coenzyme A binding pocket [chemical binding]; other site 1037911015194 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904 1037911015195 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1037911015196 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911015197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911015198 active site 1037911015199 phosphorylation site [posttranslational modification] 1037911015200 intermolecular recognition site; other site 1037911015201 dimerization interface [polypeptide binding]; other site 1037911015202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911015203 PAS domain; Region: PAS_9; pfam13426 1037911015204 putative active site [active] 1037911015205 heme pocket [chemical binding]; other site 1037911015206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911015207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911015208 metal binding site [ion binding]; metal-binding site 1037911015209 active site 1037911015210 I-site; other site 1037911015211 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911015212 Alginate lyase; Region: Alginate_lyase2; pfam08787 1037911015213 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1037911015214 intersubunit interface [polypeptide binding]; other site 1037911015215 active site 1037911015216 zinc binding site [ion binding]; other site 1037911015217 Na+ binding site [ion binding]; other site 1037911015218 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1037911015219 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1037911015220 Phosphoglycerate kinase; Region: PGK; pfam00162 1037911015221 substrate binding site [chemical binding]; other site 1037911015222 hinge regions; other site 1037911015223 ADP binding site [chemical binding]; other site 1037911015224 catalytic site [active] 1037911015225 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1037911015226 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1037911015227 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1037911015228 transketolase; Reviewed; Region: PRK12753 1037911015229 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1037911015230 TPP-binding site [chemical binding]; other site 1037911015231 dimer interface [polypeptide binding]; other site 1037911015232 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1037911015233 PYR/PP interface [polypeptide binding]; other site 1037911015234 dimer interface [polypeptide binding]; other site 1037911015235 TPP binding site [chemical binding]; other site 1037911015236 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1037911015237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911015238 putative DNA binding site [nucleotide binding]; other site 1037911015239 dimerization interface [polypeptide binding]; other site 1037911015240 putative Zn2+ binding site [ion binding]; other site 1037911015241 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1037911015242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911015243 S-adenosylmethionine binding site [chemical binding]; other site 1037911015244 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1037911015245 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1037911015246 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1037911015247 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1037911015248 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1037911015249 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1037911015250 nucleotide binding pocket [chemical binding]; other site 1037911015251 K-X-D-G motif; other site 1037911015252 catalytic site [active] 1037911015253 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1037911015254 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1037911015255 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1037911015256 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1037911015257 MltA specific insert domain; Region: MltA; pfam03562 1037911015258 3D domain; Region: 3D; pfam06725 1037911015259 Predicted membrane protein [Function unknown]; Region: COG3686 1037911015260 EamA-like transporter family; Region: EamA; pfam00892 1037911015261 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1037911015262 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1037911015263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911015264 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911015265 dimerization interface [polypeptide binding]; other site 1037911015266 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1037911015267 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911015268 putative metal binding site [ion binding]; other site 1037911015269 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1037911015270 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1037911015271 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1037911015272 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1037911015273 active site 1037911015274 nucleophile elbow; other site 1037911015275 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1037911015276 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1037911015277 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1037911015278 homotetramer interface [polypeptide binding]; other site 1037911015279 ligand binding site [chemical binding]; other site 1037911015280 catalytic site [active] 1037911015281 NAD binding site [chemical binding]; other site 1037911015282 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1037911015283 FAD binding site [chemical binding]; other site 1037911015284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911015285 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911015286 substrate binding pocket [chemical binding]; other site 1037911015287 membrane-bound complex binding site; other site 1037911015288 hinge residues; other site 1037911015289 helicase 45; Provisional; Region: PTZ00424 1037911015290 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1037911015291 ATP binding site [chemical binding]; other site 1037911015292 Mg++ binding site [ion binding]; other site 1037911015293 motif III; other site 1037911015294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911015295 nucleotide binding region [chemical binding]; other site 1037911015296 ATP-binding site [chemical binding]; other site 1037911015297 YceI-like domain; Region: YceI; cl01001 1037911015298 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1037911015299 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1037911015300 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911015301 inhibitor-cofactor binding pocket; inhibition site 1037911015302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911015303 catalytic residue [active] 1037911015304 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1037911015305 RNA methyltransferase, RsmE family; Region: TIGR00046 1037911015306 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1037911015307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911015308 substrate binding pocket [chemical binding]; other site 1037911015309 membrane-bound complex binding site; other site 1037911015310 hinge residues; other site 1037911015311 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1037911015312 homotrimer interaction site [polypeptide binding]; other site 1037911015313 putative active site [active] 1037911015314 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1037911015315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1037911015316 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1037911015317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911015318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911015319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911015320 dimerization interface [polypeptide binding]; other site 1037911015321 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1037911015322 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1037911015323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911015324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911015325 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1037911015326 putative dimerization interface [polypeptide binding]; other site 1037911015327 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1037911015328 Malonate transporter MadL subunit; Region: MadL; cl04273 1037911015329 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1037911015330 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1037911015331 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1037911015332 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1037911015333 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1037911015334 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1037911015335 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 1037911015336 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1037911015337 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1037911015338 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1037911015339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911015340 sequence-specific DNA binding site [nucleotide binding]; other site 1037911015341 salt bridge; other site 1037911015342 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1037911015343 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911015344 putative binding surface; other site 1037911015345 active site 1037911015346 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911015347 putative binding surface; other site 1037911015348 active site 1037911015349 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1037911015350 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911015351 putative binding surface; other site 1037911015352 active site 1037911015353 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1037911015354 putative binding surface; other site 1037911015355 active site 1037911015356 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1037911015357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911015358 ATP binding site [chemical binding]; other site 1037911015359 Mg2+ binding site [ion binding]; other site 1037911015360 G-X-G motif; other site 1037911015361 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1037911015362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911015363 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911015364 active site 1037911015365 phosphorylation site [posttranslational modification] 1037911015366 intermolecular recognition site; other site 1037911015367 dimerization interface [polypeptide binding]; other site 1037911015368 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1037911015369 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911015370 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911015371 dimer interface [polypeptide binding]; other site 1037911015372 putative CheW interface [polypeptide binding]; other site 1037911015373 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1037911015374 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911015375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911015376 active site 1037911015377 phosphorylation site [posttranslational modification] 1037911015378 intermolecular recognition site; other site 1037911015379 dimerization interface [polypeptide binding]; other site 1037911015380 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911015381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911015382 active site 1037911015383 phosphorylation site [posttranslational modification] 1037911015384 intermolecular recognition site; other site 1037911015385 dimerization interface [polypeptide binding]; other site 1037911015386 glutathione synthetase; Provisional; Region: PRK05246 1037911015387 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1037911015388 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1037911015389 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1037911015390 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1037911015391 hypothetical protein; Validated; Region: PRK00228 1037911015392 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1037911015393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911015394 active site 1037911015395 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1037911015396 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1037911015397 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1037911015398 dihydroorotase; Validated; Region: pyrC; PRK09357 1037911015399 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1037911015400 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1037911015401 active site 1037911015402 TM2 domain; Region: TM2; cl00984 1037911015403 TM2 domain; Region: TM2; cl00984 1037911015404 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1037911015405 NlpC/P60 family; Region: NLPC_P60; pfam00877 1037911015406 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1037911015407 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1037911015408 Walker A motif; other site 1037911015409 ATP binding site [chemical binding]; other site 1037911015410 Walker B motif; other site 1037911015411 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1037911015412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1037911015413 catalytic residue [active] 1037911015414 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1037911015415 pyrroline-5-carboxylate reductase; Region: PLN02688 1037911015416 YGGT family; Region: YGGT; pfam02325 1037911015417 YGGT family; Region: YGGT; pfam02325 1037911015418 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1037911015419 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1037911015420 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1037911015421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911015422 S-adenosylmethionine binding site [chemical binding]; other site 1037911015423 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1037911015424 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1037911015425 active site 1037911015426 dimerization interface [polypeptide binding]; other site 1037911015427 HemN family oxidoreductase; Provisional; Region: PRK05660 1037911015428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1037911015429 FeS/SAM binding site; other site 1037911015430 HemN C-terminal domain; Region: HemN_C; pfam06969 1037911015431 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 1037911015432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911015433 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1037911015434 S-adenosylmethionine binding site [chemical binding]; other site 1037911015435 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1037911015436 ThiS interaction site; other site 1037911015437 putative active site [active] 1037911015438 tetramer interface [polypeptide binding]; other site 1037911015439 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1037911015440 thiS-thiF/thiG interaction site; other site 1037911015441 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1037911015442 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1037911015443 Transglycosylase; Region: Transgly; cl17702 1037911015444 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1037911015445 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1037911015446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911015447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911015448 DNA binding residues [nucleotide binding] 1037911015449 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1037911015450 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1037911015451 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1037911015452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911015453 Walker A/P-loop; other site 1037911015454 ATP binding site [chemical binding]; other site 1037911015455 Q-loop/lid; other site 1037911015456 ABC transporter signature motif; other site 1037911015457 Walker B; other site 1037911015458 D-loop; other site 1037911015459 H-loop/switch region; other site 1037911015460 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1037911015461 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1037911015462 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1037911015463 P loop; other site 1037911015464 GTP binding site [chemical binding]; other site 1037911015465 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1037911015466 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1037911015467 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1037911015468 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1037911015469 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1037911015470 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1037911015471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911015472 S-adenosylmethionine binding site [chemical binding]; other site 1037911015473 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1037911015474 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1037911015475 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1037911015476 active site residue [active] 1037911015477 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1037911015478 active site residue [active] 1037911015479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911015480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911015481 Bacterial transcriptional repressor; Region: TetR; pfam13972 1037911015482 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1037911015483 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1037911015484 NAD(P) binding site [chemical binding]; other site 1037911015485 catalytic residues [active] 1037911015486 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1037911015487 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1037911015488 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1037911015489 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1037911015490 active site 1037911015491 (T/H)XGH motif; other site 1037911015492 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1037911015493 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1037911015494 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1037911015495 DNA binding site [nucleotide binding] 1037911015496 catalytic residue [active] 1037911015497 H2TH interface [polypeptide binding]; other site 1037911015498 putative catalytic residues [active] 1037911015499 turnover-facilitating residue; other site 1037911015500 intercalation triad [nucleotide binding]; other site 1037911015501 8OG recognition residue [nucleotide binding]; other site 1037911015502 putative reading head residues; other site 1037911015503 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1037911015504 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1037911015505 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1037911015506 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1037911015507 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1037911015508 putative RNA binding site [nucleotide binding]; other site 1037911015509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911015510 S-adenosylmethionine binding site [chemical binding]; other site 1037911015511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1037911015512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911015513 putative substrate translocation pore; other site 1037911015514 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1037911015515 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1037911015516 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1037911015517 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1037911015518 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1037911015519 folate binding site [chemical binding]; other site 1037911015520 NADP+ binding site [chemical binding]; other site 1037911015521 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1037911015522 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1037911015523 G1 box; other site 1037911015524 GTP/Mg2+ binding site [chemical binding]; other site 1037911015525 G2 box; other site 1037911015526 Switch I region; other site 1037911015527 G3 box; other site 1037911015528 Switch II region; other site 1037911015529 G4 box; other site 1037911015530 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1037911015531 G5 box; other site 1037911015532 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1037911015533 Zn2+ binding site [ion binding]; other site 1037911015534 Mg2+ binding site [ion binding]; other site 1037911015535 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1037911015536 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911015537 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1037911015538 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1037911015539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015540 dimer interface [polypeptide binding]; other site 1037911015541 conserved gate region; other site 1037911015542 putative PBP binding loops; other site 1037911015543 ABC-ATPase subunit interface; other site 1037911015544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015545 dimer interface [polypeptide binding]; other site 1037911015546 conserved gate region; other site 1037911015547 putative PBP binding loops; other site 1037911015548 ABC-ATPase subunit interface; other site 1037911015549 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1037911015550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911015551 Walker A/P-loop; other site 1037911015552 ATP binding site [chemical binding]; other site 1037911015553 Q-loop/lid; other site 1037911015554 ABC transporter signature motif; other site 1037911015555 Walker B; other site 1037911015556 D-loop; other site 1037911015557 H-loop/switch region; other site 1037911015558 TOBE domain; Region: TOBE_2; pfam08402 1037911015559 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1037911015560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911015561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911015562 dimerization interface [polypeptide binding]; other site 1037911015563 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1037911015564 Heavy-metal-associated domain; Region: HMA; pfam00403 1037911015565 metal-binding site [ion binding] 1037911015566 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1037911015567 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1037911015568 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1037911015569 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1037911015570 DNA binding residues [nucleotide binding] 1037911015571 dimer interface [polypeptide binding]; other site 1037911015572 putative metal binding site [ion binding]; other site 1037911015573 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1037911015574 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1037911015575 dimerization interface [polypeptide binding]; other site 1037911015576 active site 1037911015577 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1037911015578 NRDE protein; Region: NRDE; cl01315 1037911015579 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1037911015580 GAF domain; Region: GAF; pfam01590 1037911015581 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1037911015582 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1037911015583 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1037911015584 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1037911015585 putative active site [active] 1037911015586 Ap4A binding site [chemical binding]; other site 1037911015587 nudix motif; other site 1037911015588 putative metal binding site [ion binding]; other site 1037911015589 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1037911015590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911015591 motif II; other site 1037911015592 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1037911015593 threonine dehydratase; Reviewed; Region: PRK09224 1037911015594 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1037911015595 tetramer interface [polypeptide binding]; other site 1037911015596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911015597 catalytic residue [active] 1037911015598 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1037911015599 putative Ile/Val binding site [chemical binding]; other site 1037911015600 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1037911015601 putative Ile/Val binding site [chemical binding]; other site 1037911015602 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1037911015603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1037911015604 active site 1037911015605 dimer interface [polypeptide binding]; other site 1037911015606 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1037911015607 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1037911015608 metal binding site [ion binding]; metal-binding site 1037911015609 Autotransporter beta-domain; Region: Autotransporter; cl17461 1037911015610 SdiA-regulated; Region: SdiA-regulated; pfam06977 1037911015611 SdiA-regulated; Region: SdiA-regulated; cd09971 1037911015612 putative active site [active] 1037911015613 SdiA-regulated; Region: SdiA-regulated; pfam06977 1037911015614 SdiA-regulated; Region: SdiA-regulated; cd09971 1037911015615 putative active site [active] 1037911015616 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1037911015617 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1037911015618 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1037911015619 FAD binding domain; Region: FAD_binding_4; pfam01565 1037911015620 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1037911015621 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1037911015622 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1037911015623 ligand binding site [chemical binding]; other site 1037911015624 NAD binding site [chemical binding]; other site 1037911015625 tetramer interface [polypeptide binding]; other site 1037911015626 catalytic site [active] 1037911015627 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1037911015628 L-serine binding site [chemical binding]; other site 1037911015629 ACT domain interface; other site 1037911015630 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1037911015631 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911015632 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911015633 substrate binding pocket [chemical binding]; other site 1037911015634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911015635 membrane-bound complex binding site; other site 1037911015636 hinge residues; other site 1037911015637 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1037911015638 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1037911015639 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1037911015640 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1037911015641 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911015642 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1037911015643 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1037911015644 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1037911015645 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1037911015646 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1037911015647 active site 1037911015648 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1037911015649 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1037911015650 conserved cys residue [active] 1037911015651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911015652 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1037911015653 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1037911015654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015655 dimer interface [polypeptide binding]; other site 1037911015656 conserved gate region; other site 1037911015657 putative PBP binding loops; other site 1037911015658 ABC-ATPase subunit interface; other site 1037911015659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015660 dimer interface [polypeptide binding]; other site 1037911015661 conserved gate region; other site 1037911015662 putative PBP binding loops; other site 1037911015663 ABC-ATPase subunit interface; other site 1037911015664 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1037911015665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911015666 Walker A/P-loop; other site 1037911015667 ATP binding site [chemical binding]; other site 1037911015668 Q-loop/lid; other site 1037911015669 ABC transporter signature motif; other site 1037911015670 Walker B; other site 1037911015671 D-loop; other site 1037911015672 H-loop/switch region; other site 1037911015673 TOBE domain; Region: TOBE_2; pfam08402 1037911015674 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1037911015675 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911015676 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1037911015677 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911015678 putative aminotransferase; Validated; Region: PRK07480 1037911015679 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1037911015680 inhibitor-cofactor binding pocket; inhibition site 1037911015681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911015682 catalytic residue [active] 1037911015683 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1037911015684 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1037911015685 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1037911015686 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1037911015687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1037911015688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1037911015689 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1037911015690 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1037911015691 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1037911015692 Walker A/P-loop; other site 1037911015693 ATP binding site [chemical binding]; other site 1037911015694 Q-loop/lid; other site 1037911015695 ABC transporter signature motif; other site 1037911015696 Walker B; other site 1037911015697 D-loop; other site 1037911015698 H-loop/switch region; other site 1037911015699 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1037911015700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015701 dimer interface [polypeptide binding]; other site 1037911015702 conserved gate region; other site 1037911015703 putative PBP binding loops; other site 1037911015704 ABC-ATPase subunit interface; other site 1037911015705 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1037911015706 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1037911015707 active site 1037911015708 dimer interface [polypeptide binding]; other site 1037911015709 non-prolyl cis peptide bond; other site 1037911015710 insertion regions; other site 1037911015711 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1037911015712 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911015713 substrate binding pocket [chemical binding]; other site 1037911015714 membrane-bound complex binding site; other site 1037911015715 hinge residues; other site 1037911015716 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1037911015717 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1037911015718 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1037911015719 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1037911015720 dimer interface [polypeptide binding]; other site 1037911015721 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1037911015722 catalytic triad [active] 1037911015723 outer membrane porin, OprD family; Region: OprD; pfam03573 1037911015724 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1037911015725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911015726 substrate binding pocket [chemical binding]; other site 1037911015727 membrane-bound complex binding site; other site 1037911015728 hinge residues; other site 1037911015729 N-acetylglutamate synthase; Validated; Region: PRK05279 1037911015730 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1037911015731 putative feedback inhibition sensing region; other site 1037911015732 putative nucleotide binding site [chemical binding]; other site 1037911015733 putative substrate binding site [chemical binding]; other site 1037911015734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911015735 Coenzyme A binding pocket [chemical binding]; other site 1037911015736 acetylornithine deacetylase; Provisional; Region: PRK05111 1037911015737 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1037911015738 metal binding site [ion binding]; metal-binding site 1037911015739 putative dimer interface [polypeptide binding]; other site 1037911015740 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1037911015741 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1037911015742 putative active site [active] 1037911015743 putative metal binding residues [ion binding]; other site 1037911015744 signature motif; other site 1037911015745 putative triphosphate binding site [ion binding]; other site 1037911015746 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1037911015747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911015748 putative DNA binding site [nucleotide binding]; other site 1037911015749 putative Zn2+ binding site [ion binding]; other site 1037911015750 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911015751 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1037911015752 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1037911015753 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1037911015754 Walker A motif; other site 1037911015755 ATP binding site [chemical binding]; other site 1037911015756 Walker B motif; other site 1037911015757 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1037911015758 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1037911015759 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1037911015760 conserverd hypothetical protein; Region: TIGR02448 1037911015761 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1037911015762 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1037911015763 inhibitor-cofactor binding pocket; inhibition site 1037911015764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911015765 catalytic residue [active] 1037911015766 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1037911015767 lipoyl attachment site [posttranslational modification]; other site 1037911015768 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1037911015769 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1037911015770 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1037911015771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015772 dimer interface [polypeptide binding]; other site 1037911015773 conserved gate region; other site 1037911015774 putative PBP binding loops; other site 1037911015775 ABC-ATPase subunit interface; other site 1037911015776 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1037911015777 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1037911015778 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1037911015779 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1037911015780 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1037911015781 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1037911015782 proline aminopeptidase P II; Provisional; Region: PRK10879 1037911015783 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1037911015784 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1037911015785 active site 1037911015786 hypothetical protein; Reviewed; Region: PRK02166 1037911015787 TIGR02449 family protein; Region: TIGR02449 1037911015788 Cell division protein ZapA; Region: ZapA; pfam05164 1037911015789 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1037911015790 EVE domain; Region: EVE; cl00728 1037911015791 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 1037911015792 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1037911015793 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1037911015794 NAD(P) binding site [chemical binding]; other site 1037911015795 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1037911015796 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1037911015797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911015798 putative substrate translocation pore; other site 1037911015799 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1037911015800 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1037911015801 putative active site pocket [active] 1037911015802 dimerization interface [polypeptide binding]; other site 1037911015803 putative catalytic residue [active] 1037911015804 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1037911015805 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911015806 N-terminal plug; other site 1037911015807 ligand-binding site [chemical binding]; other site 1037911015808 Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine...; Region: PTPA; cl03888 1037911015809 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1037911015810 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911015811 catalytic loop [active] 1037911015812 iron binding site [ion binding]; other site 1037911015813 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1037911015814 FAD binding pocket [chemical binding]; other site 1037911015815 FAD binding motif [chemical binding]; other site 1037911015816 phosphate binding motif [ion binding]; other site 1037911015817 beta-alpha-beta structure motif; other site 1037911015818 NAD binding pocket [chemical binding]; other site 1037911015819 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1037911015820 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1037911015821 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1037911015822 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1037911015823 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1037911015824 RNA binding site [nucleotide binding]; other site 1037911015825 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1037911015826 multimer interface [polypeptide binding]; other site 1037911015827 Walker A motif; other site 1037911015828 ATP binding site [chemical binding]; other site 1037911015829 Walker B motif; other site 1037911015830 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1037911015831 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1037911015832 catalytic residues [active] 1037911015833 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1037911015834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911015835 DNA-binding site [nucleotide binding]; DNA binding site 1037911015836 FCD domain; Region: FCD; pfam07729 1037911015837 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911015838 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911015839 substrate binding pocket [chemical binding]; other site 1037911015840 membrane-bound complex binding site; other site 1037911015841 hinge residues; other site 1037911015842 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911015843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015844 dimer interface [polypeptide binding]; other site 1037911015845 conserved gate region; other site 1037911015846 putative PBP binding loops; other site 1037911015847 ABC-ATPase subunit interface; other site 1037911015848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911015849 dimer interface [polypeptide binding]; other site 1037911015850 conserved gate region; other site 1037911015851 putative PBP binding loops; other site 1037911015852 ABC-ATPase subunit interface; other site 1037911015853 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1037911015854 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1037911015855 Walker A/P-loop; other site 1037911015856 ATP binding site [chemical binding]; other site 1037911015857 Q-loop/lid; other site 1037911015858 ABC transporter signature motif; other site 1037911015859 Walker B; other site 1037911015860 D-loop; other site 1037911015861 H-loop/switch region; other site 1037911015862 hypothetical protein; Provisional; Region: PRK15301 1037911015863 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1037911015864 PapC N-terminal domain; Region: PapC_N; pfam13954 1037911015865 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1037911015866 PapC C-terminal domain; Region: PapC_C; pfam13953 1037911015867 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1037911015868 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1037911015869 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1037911015870 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1037911015871 polyphosphate kinase; Provisional; Region: PRK05443 1037911015872 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1037911015873 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1037911015874 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1037911015875 putative active site [active] 1037911015876 catalytic site [active] 1037911015877 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1037911015878 putative domain interface [polypeptide binding]; other site 1037911015879 putative active site [active] 1037911015880 catalytic site [active] 1037911015881 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1037911015882 dimer interface [polypeptide binding]; other site 1037911015883 active site 1037911015884 aspartate-rich active site metal binding site; other site 1037911015885 allosteric magnesium binding site [ion binding]; other site 1037911015886 Schiff base residues; other site 1037911015887 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1037911015888 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1037911015889 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1037911015890 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1037911015891 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1037911015892 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1037911015893 conserved cys residue [active] 1037911015894 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1037911015895 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1037911015896 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1037911015897 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1037911015898 LysE type translocator; Region: LysE; cl00565 1037911015899 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1037911015900 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1037911015901 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1037911015902 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911015903 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911015904 ABC transporter; Region: ABC_tran_2; pfam12848 1037911015905 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1037911015906 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1037911015907 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1037911015908 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1037911015909 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1037911015910 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1037911015911 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1037911015912 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1037911015913 HemY protein N-terminus; Region: HemY_N; pfam07219 1037911015914 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1037911015915 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1037911015916 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1037911015917 active site 1037911015918 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1037911015919 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1037911015920 domain interfaces; other site 1037911015921 active site 1037911015922 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1037911015923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911015924 active site 1037911015925 phosphorylation site [posttranslational modification] 1037911015926 intermolecular recognition site; other site 1037911015927 dimerization interface [polypeptide binding]; other site 1037911015928 LytTr DNA-binding domain; Region: LytTR; pfam04397 1037911015929 argininosuccinate lyase; Provisional; Region: PRK00855 1037911015930 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1037911015931 active sites [active] 1037911015932 tetramer interface [polypeptide binding]; other site 1037911015933 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1037911015934 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1037911015935 C-terminal domain interface [polypeptide binding]; other site 1037911015936 GSH binding site (G-site) [chemical binding]; other site 1037911015937 dimer interface [polypeptide binding]; other site 1037911015938 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1037911015939 N-terminal domain interface [polypeptide binding]; other site 1037911015940 dimer interface [polypeptide binding]; other site 1037911015941 substrate binding pocket (H-site) [chemical binding]; other site 1037911015942 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1037911015943 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1037911015944 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1037911015945 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1037911015946 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1037911015947 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1037911015948 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1037911015949 frataxin-like protein; Provisional; Region: cyaY; PRK00446 1037911015950 putative iron binding site [ion binding]; other site 1037911015951 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1037911015952 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1037911015953 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1037911015954 active site 1037911015955 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1037911015956 substrate binding site [chemical binding]; other site 1037911015957 catalytic residues [active] 1037911015958 dimer interface [polypeptide binding]; other site 1037911015959 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1037911015960 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1037911015961 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1037911015962 Protein of unknown function, DUF484; Region: DUF484; cl17449 1037911015963 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1037911015964 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1037911015965 active site 1037911015966 DNA binding site [nucleotide binding] 1037911015967 Int/Topo IB signature motif; other site 1037911015968 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1037911015969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1037911015970 motif II; other site 1037911015971 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1037911015972 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1037911015973 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1037911015974 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1037911015975 Membrane fusogenic activity; Region: BMFP; pfam04380 1037911015976 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1037911015977 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1037911015978 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1037911015979 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1037911015980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1037911015981 dimerization interface [polypeptide binding]; other site 1037911015982 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1037911015983 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1037911015984 dimer interface [polypeptide binding]; other site 1037911015985 putative CheW interface [polypeptide binding]; other site 1037911015986 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1037911015987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911015988 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1037911015989 dimerization interface [polypeptide binding]; other site 1037911015990 multidrug efflux protein NorA; Provisional; Region: PRK00187 1037911015991 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1037911015992 cation binding site [ion binding]; other site 1037911015993 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911015994 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911015995 metal binding site [ion binding]; metal-binding site 1037911015996 active site 1037911015997 I-site; other site 1037911015998 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911015999 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1037911016000 Part of AAA domain; Region: AAA_19; pfam13245 1037911016001 Family description; Region: UvrD_C_2; pfam13538 1037911016002 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911016003 active site 1037911016004 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1037911016005 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1037911016006 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1037911016007 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1037911016008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911016009 non-specific DNA binding site [nucleotide binding]; other site 1037911016010 salt bridge; other site 1037911016011 sequence-specific DNA binding site [nucleotide binding]; other site 1037911016012 Cupin domain; Region: Cupin_2; pfam07883 1037911016013 alanine racemase; Reviewed; Region: dadX; PRK03646 1037911016014 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1037911016015 active site 1037911016016 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1037911016017 substrate binding site [chemical binding]; other site 1037911016018 catalytic residues [active] 1037911016019 dimer interface [polypeptide binding]; other site 1037911016020 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1037911016021 homotrimer interaction site [polypeptide binding]; other site 1037911016022 putative active site [active] 1037911016023 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1037911016024 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1037911016025 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1037911016026 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1037911016027 putative DNA binding site [nucleotide binding]; other site 1037911016028 putative Zn2+ binding site [ion binding]; other site 1037911016029 AsnC family; Region: AsnC_trans_reg; pfam01037 1037911016030 Flagellin N-methylase; Region: FliB; pfam03692 1037911016031 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1037911016032 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1037911016033 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1037911016034 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1037911016035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1037911016036 DNA-binding site [nucleotide binding]; DNA binding site 1037911016037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1037911016038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1037911016039 homodimer interface [polypeptide binding]; other site 1037911016040 catalytic residue [active] 1037911016041 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1037911016042 PLD-like domain; Region: PLDc_2; pfam13091 1037911016043 putative active site [active] 1037911016044 catalytic site [active] 1037911016045 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1037911016046 PLD-like domain; Region: PLDc_2; pfam13091 1037911016047 putative active site [active] 1037911016048 catalytic site [active] 1037911016049 enterobactin exporter EntS; Provisional; Region: PRK10489 1037911016050 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1037911016051 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1037911016052 NAD(P) binding site [chemical binding]; other site 1037911016053 catalytic residues [active] 1037911016054 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1037911016055 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1037911016056 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1037911016057 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1037911016058 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1037911016059 peptide binding site [polypeptide binding]; other site 1037911016060 hypothetical protein; Reviewed; Region: PRK00024 1037911016061 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1037911016062 MPN+ (JAMM) motif; other site 1037911016063 Zinc-binding site [ion binding]; other site 1037911016064 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1037911016065 Flavoprotein; Region: Flavoprotein; pfam02441 1037911016066 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1037911016067 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1037911016068 trimer interface [polypeptide binding]; other site 1037911016069 active site 1037911016070 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1037911016071 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1037911016072 active site 1037911016073 substrate binding site [chemical binding]; other site 1037911016074 metal binding site [ion binding]; metal-binding site 1037911016075 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1037911016076 feedback inhibition sensing region; other site 1037911016077 homohexameric interface [polypeptide binding]; other site 1037911016078 nucleotide binding site [chemical binding]; other site 1037911016079 N-acetyl-L-glutamate binding site [chemical binding]; other site 1037911016080 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1037911016081 active site 1037911016082 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1037911016083 putative active site [active] 1037911016084 putative catalytic site [active] 1037911016085 putative DNA binding site [nucleotide binding]; other site 1037911016086 putative phosphate binding site [ion binding]; other site 1037911016087 metal binding site A [ion binding]; metal-binding site 1037911016088 putative AP binding site [nucleotide binding]; other site 1037911016089 putative metal binding site B [ion binding]; other site 1037911016090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1037911016091 ribonuclease PH; Reviewed; Region: rph; PRK00173 1037911016092 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1037911016093 hexamer interface [polypeptide binding]; other site 1037911016094 active site 1037911016095 hypothetical protein; Provisional; Region: PRK11820 1037911016096 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1037911016097 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1037911016098 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1037911016099 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1037911016100 catalytic site [active] 1037911016101 G-X2-G-X-G-K; other site 1037911016102 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1037911016103 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1037911016104 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1037911016105 Zn2+ binding site [ion binding]; other site 1037911016106 Mg2+ binding site [ion binding]; other site 1037911016107 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1037911016108 synthetase active site [active] 1037911016109 NTP binding site [chemical binding]; other site 1037911016110 metal binding site [ion binding]; metal-binding site 1037911016111 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1037911016112 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1037911016113 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1037911016114 homotrimer interaction site [polypeptide binding]; other site 1037911016115 putative active site [active] 1037911016116 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1037911016117 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1037911016118 putative NAD(P) binding site [chemical binding]; other site 1037911016119 tonB-system energizer ExbB; Region: exbB; TIGR02797 1037911016120 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1037911016121 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1037911016122 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1037911016123 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1037911016124 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1037911016125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911016126 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1037911016127 dimerization interface [polypeptide binding]; other site 1037911016128 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1037911016129 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1037911016130 generic binding surface II; other site 1037911016131 ssDNA binding site; other site 1037911016132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1037911016133 ATP binding site [chemical binding]; other site 1037911016134 putative Mg++ binding site [ion binding]; other site 1037911016135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1037911016136 nucleotide binding region [chemical binding]; other site 1037911016137 ATP-binding site [chemical binding]; other site 1037911016138 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1037911016139 putative deacylase active site [active] 1037911016140 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1037911016141 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1037911016142 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1037911016143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911016144 Walker A/P-loop; other site 1037911016145 ATP binding site [chemical binding]; other site 1037911016146 Q-loop/lid; other site 1037911016147 ABC transporter signature motif; other site 1037911016148 Walker B; other site 1037911016149 D-loop; other site 1037911016150 H-loop/switch region; other site 1037911016151 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1037911016152 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1037911016153 active site 1037911016154 ATP binding site [chemical binding]; other site 1037911016155 substrate binding site [chemical binding]; other site 1037911016156 activation loop (A-loop); other site 1037911016157 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1037911016158 metal ion-dependent adhesion site (MIDAS); other site 1037911016159 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1037911016160 Protein phosphatase 2C; Region: PP2C; pfam00481 1037911016161 active site 1037911016162 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1037911016163 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1037911016164 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1037911016165 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1037911016166 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1037911016167 hypothetical protein; Provisional; Region: PRK07033 1037911016168 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1037911016169 ligand binding site [chemical binding]; other site 1037911016170 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1037911016171 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1037911016172 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 1037911016173 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1037911016174 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1037911016175 phosphopeptide binding site; other site 1037911016176 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1037911016177 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1037911016178 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1037911016179 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1037911016180 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1037911016181 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1037911016182 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1037911016183 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1037911016184 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1037911016185 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1037911016186 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1037911016187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911016188 Walker A motif; other site 1037911016189 ATP binding site [chemical binding]; other site 1037911016190 Walker B motif; other site 1037911016191 arginine finger; other site 1037911016192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1037911016193 Walker A motif; other site 1037911016194 ATP binding site [chemical binding]; other site 1037911016195 Walker B motif; other site 1037911016196 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1037911016197 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1037911016198 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1037911016199 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1037911016200 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1037911016201 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1037911016202 PAAR motif; Region: PAAR_motif; pfam05488 1037911016203 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1037911016204 RHS Repeat; Region: RHS_repeat; cl11982 1037911016205 RHS Repeat; Region: RHS_repeat; pfam05593 1037911016206 RHS Repeat; Region: RHS_repeat; pfam05593 1037911016207 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1037911016208 RHS protein; Region: RHS; pfam03527 1037911016209 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1037911016210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1037911016211 Transposase; Region: HTH_Tnp_1; pfam01527 1037911016212 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1037911016213 IHF dimer interface [polypeptide binding]; other site 1037911016214 IHF - DNA interface [nucleotide binding]; other site 1037911016215 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1037911016216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1037911016217 Rubredoxin [Energy production and conversion]; Region: COG1773 1037911016218 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1037911016219 iron binding site [ion binding]; other site 1037911016220 Chorismate lyase; Region: Chor_lyase; cl01230 1037911016221 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1037911016222 UbiA prenyltransferase family; Region: UbiA; pfam01040 1037911016223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 1037911016224 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1037911016225 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1037911016226 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1037911016227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911016228 active site 1037911016229 phosphorylation site [posttranslational modification] 1037911016230 intermolecular recognition site; other site 1037911016231 dimerization interface [polypeptide binding]; other site 1037911016232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1037911016233 DNA binding site [nucleotide binding] 1037911016234 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1037911016235 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1037911016236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911016237 putative active site [active] 1037911016238 heme pocket [chemical binding]; other site 1037911016239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1037911016240 dimer interface [polypeptide binding]; other site 1037911016241 phosphorylation site [posttranslational modification] 1037911016242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1037911016243 ATP binding site [chemical binding]; other site 1037911016244 Mg2+ binding site [ion binding]; other site 1037911016245 G-X-G motif; other site 1037911016246 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1037911016247 Domain of unknown function DUF21; Region: DUF21; pfam01595 1037911016248 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1037911016249 Transporter associated domain; Region: CorC_HlyC; smart01091 1037911016250 Response regulator receiver domain; Region: Response_reg; pfam00072 1037911016251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1037911016252 active site 1037911016253 phosphorylation site [posttranslational modification] 1037911016254 intermolecular recognition site; other site 1037911016255 dimerization interface [polypeptide binding]; other site 1037911016256 transcriptional regulator PhoU; Provisional; Region: PRK11115 1037911016257 PhoU domain; Region: PhoU; pfam01895 1037911016258 PhoU domain; Region: PhoU; pfam01895 1037911016259 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1037911016260 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1037911016261 Walker A/P-loop; other site 1037911016262 ATP binding site [chemical binding]; other site 1037911016263 Q-loop/lid; other site 1037911016264 ABC transporter signature motif; other site 1037911016265 Walker B; other site 1037911016266 D-loop; other site 1037911016267 H-loop/switch region; other site 1037911016268 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1037911016269 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1037911016270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911016271 dimer interface [polypeptide binding]; other site 1037911016272 conserved gate region; other site 1037911016273 putative PBP binding loops; other site 1037911016274 ABC-ATPase subunit interface; other site 1037911016275 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1037911016276 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 1037911016277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911016278 dimer interface [polypeptide binding]; other site 1037911016279 conserved gate region; other site 1037911016280 putative PBP binding loops; other site 1037911016281 ABC-ATPase subunit interface; other site 1037911016282 PBP superfamily domain; Region: PBP_like_2; cl17296 1037911016283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1037911016284 metabolite-proton symporter; Region: 2A0106; TIGR00883 1037911016285 putative substrate translocation pore; other site 1037911016286 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1037911016287 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1037911016288 active site 1037911016289 phosphate binding residues; other site 1037911016290 catalytic residues [active] 1037911016291 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1037911016292 Predicted membrane protein [Function unknown]; Region: COG2261 1037911016293 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1037911016294 ATP-grasp domain; Region: ATP-grasp; pfam02222 1037911016295 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1037911016296 cell density-dependent motility repressor; Provisional; Region: PRK10082 1037911016297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911016298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1037911016299 dimerization interface [polypeptide binding]; other site 1037911016300 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1037911016301 Aspartase; Region: Aspartase; cd01357 1037911016302 active sites [active] 1037911016303 tetramer interface [polypeptide binding]; other site 1037911016304 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1037911016305 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1037911016306 Walker A/P-loop; other site 1037911016307 ATP binding site [chemical binding]; other site 1037911016308 Q-loop/lid; other site 1037911016309 ABC transporter signature motif; other site 1037911016310 Walker B; other site 1037911016311 D-loop; other site 1037911016312 H-loop/switch region; other site 1037911016313 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1037911016314 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1037911016315 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1037911016316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911016317 dimer interface [polypeptide binding]; other site 1037911016318 conserved gate region; other site 1037911016319 putative PBP binding loops; other site 1037911016320 ABC-ATPase subunit interface; other site 1037911016321 short chain dehydrogenase; Provisional; Region: PRK12939 1037911016322 classical (c) SDRs; Region: SDR_c; cd05233 1037911016323 NAD(P) binding site [chemical binding]; other site 1037911016324 active site 1037911016325 Cupin domain; Region: Cupin_2; pfam07883 1037911016326 Serine hydrolase; Region: Ser_hydrolase; cl17834 1037911016327 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1037911016328 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1037911016329 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1037911016330 Bacterial transcriptional regulator; Region: IclR; pfam01614 1037911016331 short chain dehydrogenase; Provisional; Region: PRK07062 1037911016332 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1037911016333 putative NAD(P) binding site [chemical binding]; other site 1037911016334 putative active site [active] 1037911016335 hypothetical protein; Provisional; Region: PRK07064 1037911016336 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1037911016337 PYR/PP interface [polypeptide binding]; other site 1037911016338 dimer interface [polypeptide binding]; other site 1037911016339 TPP binding site [chemical binding]; other site 1037911016340 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1037911016341 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1037911016342 TPP-binding site [chemical binding]; other site 1037911016343 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1037911016344 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1037911016345 Domain of unknown function DUF108; Region: DUF108; pfam01958 1037911016346 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1037911016347 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1037911016348 NAD(P) binding site [chemical binding]; other site 1037911016349 catalytic residues [active] 1037911016350 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1037911016351 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1037911016352 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1037911016353 putative active site [active] 1037911016354 putative metal binding site [ion binding]; other site 1037911016355 FAD binding domain; Region: FAD_binding_3; pfam01494 1037911016356 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1037911016357 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1037911016358 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1037911016359 [2Fe-2S] cluster binding site [ion binding]; other site 1037911016360 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1037911016361 hydrophobic ligand binding site; other site 1037911016362 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1037911016363 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1037911016364 FMN-binding pocket [chemical binding]; other site 1037911016365 flavin binding motif; other site 1037911016366 phosphate binding motif [ion binding]; other site 1037911016367 beta-alpha-beta structure motif; other site 1037911016368 NAD binding pocket [chemical binding]; other site 1037911016369 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1037911016370 catalytic loop [active] 1037911016371 iron binding site [ion binding]; other site 1037911016372 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1037911016373 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1037911016374 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1037911016375 active site 1037911016376 homodimer interface [polypeptide binding]; other site 1037911016377 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1037911016378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1037911016379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1037911016380 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1037911016381 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1037911016382 active site 1037911016383 Zn binding site [ion binding]; other site 1037911016384 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1037911016385 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1037911016386 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1037911016387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1037911016388 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1037911016389 Coenzyme A binding pocket [chemical binding]; other site 1037911016390 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1037911016391 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1037911016392 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 1037911016393 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1037911016394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1037911016395 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1037911016396 substrate binding pocket [chemical binding]; other site 1037911016397 membrane-bound complex binding site; other site 1037911016398 hinge residues; other site 1037911016399 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1037911016400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1037911016401 dimer interface [polypeptide binding]; other site 1037911016402 conserved gate region; other site 1037911016403 putative PBP binding loops; other site 1037911016404 ABC-ATPase subunit interface; other site 1037911016405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1037911016406 non-specific DNA binding site [nucleotide binding]; other site 1037911016407 salt bridge; other site 1037911016408 sequence-specific DNA binding site [nucleotide binding]; other site 1037911016409 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1037911016410 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1037911016411 Autotransporter beta-domain; Region: Autotransporter; smart00869 1037911016412 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1037911016413 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1037911016414 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1037911016415 active site 1037911016416 catalytic residues [active] 1037911016417 metal binding site [ion binding]; metal-binding site 1037911016418 homodimer binding site [polypeptide binding]; other site 1037911016419 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1037911016420 carboxyltransferase (CT) interaction site; other site 1037911016421 biotinylation site [posttranslational modification]; other site 1037911016422 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1037911016423 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1037911016424 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1037911016425 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1037911016426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1037911016427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1037911016428 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1037911016429 putative dimerization interface [polypeptide binding]; other site 1037911016430 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1037911016431 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1037911016432 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1037911016433 putative active site [active] 1037911016434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911016435 PAS fold; Region: PAS_3; pfam08447 1037911016436 putative active site [active] 1037911016437 heme pocket [chemical binding]; other site 1037911016438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1037911016439 PAS domain; Region: PAS_9; pfam13426 1037911016440 putative active site [active] 1037911016441 heme pocket [chemical binding]; other site 1037911016442 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1037911016443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1037911016444 metal binding site [ion binding]; metal-binding site 1037911016445 active site 1037911016446 I-site; other site 1037911016447 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1037911016448 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1037911016449 Part of AAA domain; Region: AAA_19; pfam13245 1037911016450 Family description; Region: UvrD_C_2; pfam13538 1037911016451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1037911016452 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1037911016453 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1037911016454 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1037911016455 pyridoxamine kinase; Validated; Region: PRK05756 1037911016456 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1037911016457 pyridoxal binding site [chemical binding]; other site 1037911016458 dimer interface [polypeptide binding]; other site 1037911016459 ATP binding site [chemical binding]; other site 1037911016460 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1037911016461 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1037911016462 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1037911016463 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1037911016464 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1037911016465 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1037911016466 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1037911016467 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1037911016468 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1037911016469 AMIN domain; Region: AMIN; pfam11741 1037911016470 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1037911016471 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1037911016472 active site 1037911016473 metal binding site [ion binding]; metal-binding site 1037911016474 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1037911016475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1037911016476 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1037911016477 Walker A/P-loop; other site 1037911016478 ATP binding site [chemical binding]; other site 1037911016479 Q-loop/lid; other site 1037911016480 ABC transporter signature motif; other site 1037911016481 Walker B; other site 1037911016482 D-loop; other site 1037911016483 H-loop/switch region; other site 1037911016484 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1037911016485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1037911016486 ABC-ATPase subunit interface; other site 1037911016487 dimer interface [polypeptide binding]; other site 1037911016488 putative PBP binding regions; other site 1037911016489 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1037911016490 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1037911016491 metal binding site [ion binding]; metal-binding site 1037911016492 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1037911016493 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1037911016494 trimer interface [polypeptide binding]; other site 1037911016495 active site 1037911016496 dihydroorotase; Reviewed; Region: PRK09236 1037911016497 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1037911016498 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1037911016499 active site 1037911016500 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1037911016501 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1037911016502 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1037911016503 putative active site [active] 1037911016504 catalytic site [active] 1037911016505 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1037911016506 putative active site [active] 1037911016507 catalytic site [active] 1037911016508 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1037911016509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911016510 S-adenosylmethionine binding site [chemical binding]; other site 1037911016511 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1037911016512 hypothetical protein; Provisional; Region: PRK05409 1037911016513 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 1037911016514 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1037911016515 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1037911016516 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1037911016517 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1037911016518 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1037911016519 HflC protein; Region: hflC; TIGR01932 1037911016520 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1037911016521 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1037911016522 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1037911016523 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1037911016524 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1037911016525 Putative methyltransferase; Region: Methyltransf_20; pfam12147 1037911016526 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1037911016527 active site 1037911016528 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1037911016529 active site 1037911016530 catalytic residues [active] 1037911016531 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1037911016532 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1037911016533 putative acyl-acceptor binding pocket; other site 1037911016534 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1037911016535 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1037911016536 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1037911016537 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1037911016538 glutaminase active site [active] 1037911016539 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1037911016540 dimer interface [polypeptide binding]; other site 1037911016541 active site 1037911016542 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1037911016543 dimer interface [polypeptide binding]; other site 1037911016544 active site 1037911016545 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1037911016546 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1037911016547 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1037911016548 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1037911016549 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1037911016550 Substrate binding site; other site 1037911016551 Mg++ binding site; other site 1037911016552 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1037911016553 active site 1037911016554 substrate binding site [chemical binding]; other site 1037911016555 CoA binding site [chemical binding]; other site 1037911016556 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1037911016557 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1037911016558 gamma subunit interface [polypeptide binding]; other site 1037911016559 epsilon subunit interface [polypeptide binding]; other site 1037911016560 LBP interface [polypeptide binding]; other site 1037911016561 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1037911016562 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1037911016563 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1037911016564 alpha subunit interaction interface [polypeptide binding]; other site 1037911016565 Walker A motif; other site 1037911016566 ATP binding site [chemical binding]; other site 1037911016567 Walker B motif; other site 1037911016568 inhibitor binding site; inhibition site 1037911016569 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1037911016570 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1037911016571 core domain interface [polypeptide binding]; other site 1037911016572 delta subunit interface [polypeptide binding]; other site 1037911016573 epsilon subunit interface [polypeptide binding]; other site 1037911016574 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1037911016575 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1037911016576 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1037911016577 beta subunit interaction interface [polypeptide binding]; other site 1037911016578 Walker A motif; other site 1037911016579 ATP binding site [chemical binding]; other site 1037911016580 Walker B motif; other site 1037911016581 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1037911016582 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1037911016583 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1037911016584 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1037911016585 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1037911016586 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1037911016587 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1037911016588 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1037911016589 ATP synthase I chain; Region: ATP_synt_I; cl09170 1037911016590 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1037911016591 ParB-like nuclease domain; Region: ParBc; pfam02195 1037911016592 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1037911016593 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1037911016594 P-loop; other site 1037911016595 Magnesium ion binding site [ion binding]; other site 1037911016596 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1037911016597 Magnesium ion binding site [ion binding]; other site 1037911016598 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1037911016599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1037911016600 S-adenosylmethionine binding site [chemical binding]; other site 1037911016601 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1037911016602 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1037911016603 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1037911016604 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1037911016605 RNA polymerase sigma factor; Provisional; Region: PRK12528 1037911016606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1037911016607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1037911016608 DNA binding residues [nucleotide binding] 1037911016609 fec operon regulator FecR; Reviewed; Region: PRK09774 1037911016610 FecR protein; Region: FecR; pfam04773 1037911016611 Secretin and TonB N terminus short domain; Region: STN; smart00965 1037911016612 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1037911016613 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1037911016614 N-terminal plug; other site 1037911016615 ligand-binding site [chemical binding]; other site 1037911016616 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1037911016617 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1037911016618 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1037911016619 G1 box; other site 1037911016620 GTP/Mg2+ binding site [chemical binding]; other site 1037911016621 Switch I region; other site 1037911016622 G2 box; other site 1037911016623 Switch II region; other site 1037911016624 G3 box; other site 1037911016625 G4 box; other site 1037911016626 G5 box; other site 1037911016627 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1037911016628 membrane protein insertase; Provisional; Region: PRK01318 1037911016629 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1037911016630 ribonuclease P; Reviewed; Region: rnpA; PRK00396