-- dump date 20140620_005107 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1124983000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1124983000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1124983000004 Walker A motif; other site 1124983000005 ATP binding site [chemical binding]; other site 1124983000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1124983000007 Walker B motif; other site 1124983000008 arginine finger; other site 1124983000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1124983000010 DnaA box-binding interface [nucleotide binding]; other site 1124983000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1124983000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1124983000013 putative DNA binding surface [nucleotide binding]; other site 1124983000014 dimer interface [polypeptide binding]; other site 1124983000015 beta-clamp/clamp loader binding surface; other site 1124983000016 beta-clamp/translesion DNA polymerase binding surface; other site 1124983000017 recombination protein F; Reviewed; Region: recF; PRK00064 1124983000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983000019 Walker A/P-loop; other site 1124983000020 ATP binding site [chemical binding]; other site 1124983000021 Q-loop/lid; other site 1124983000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983000023 ABC transporter signature motif; other site 1124983000024 Walker B; other site 1124983000025 D-loop; other site 1124983000026 H-loop/switch region; other site 1124983000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1124983000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983000029 Mg2+ binding site [ion binding]; other site 1124983000030 G-X-G motif; other site 1124983000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1124983000032 anchoring element; other site 1124983000033 dimer interface [polypeptide binding]; other site 1124983000034 ATP binding site [chemical binding]; other site 1124983000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1124983000036 active site 1124983000037 putative metal-binding site [ion binding]; other site 1124983000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1124983000039 Immunity protein Imm1; Region: Imm1; pfam14430 1124983000040 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1124983000041 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1124983000042 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983000043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983000044 active site 1124983000045 phosphorylation site [posttranslational modification] 1124983000046 intermolecular recognition site; other site 1124983000047 dimerization interface [polypeptide binding]; other site 1124983000048 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983000049 DNA binding site [nucleotide binding] 1124983000050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 1124983000051 FecR protein; Region: FecR; pfam04773 1124983000052 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1124983000053 CHASE2 domain; Region: CHASE2; pfam05226 1124983000054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983000055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983000056 dimer interface [polypeptide binding]; other site 1124983000057 phosphorylation site [posttranslational modification] 1124983000058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983000059 ATP binding site [chemical binding]; other site 1124983000060 Mg2+ binding site [ion binding]; other site 1124983000061 G-X-G motif; other site 1124983000062 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124983000063 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1124983000064 putative acyl-acceptor binding pocket; other site 1124983000065 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1124983000066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983000067 active site 1124983000068 motif I; other site 1124983000069 motif II; other site 1124983000070 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1124983000071 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1124983000072 dimer interface [polypeptide binding]; other site 1124983000073 motif 1; other site 1124983000074 active site 1124983000075 motif 2; other site 1124983000076 motif 3; other site 1124983000077 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1124983000078 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1124983000079 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1124983000080 putative acyl-acceptor binding pocket; other site 1124983000081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983000082 TPR motif; other site 1124983000083 TPR repeat; Region: TPR_11; pfam13414 1124983000084 binding surface 1124983000085 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1124983000086 TrkA-N domain; Region: TrkA_N; pfam02254 1124983000087 TrkA-C domain; Region: TrkA_C; pfam02080 1124983000088 TrkA-N domain; Region: TrkA_N; pfam02254 1124983000089 TrkA-C domain; Region: TrkA_C; pfam02080 1124983000090 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1124983000091 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1124983000092 putative RNA binding site [nucleotide binding]; other site 1124983000093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983000094 S-adenosylmethionine binding site [chemical binding]; other site 1124983000095 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1124983000096 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1124983000097 putative active site [active] 1124983000098 substrate binding site [chemical binding]; other site 1124983000099 putative cosubstrate binding site; other site 1124983000100 catalytic site [active] 1124983000101 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1124983000102 substrate binding site [chemical binding]; other site 1124983000103 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1124983000104 active site 1124983000105 catalytic residues [active] 1124983000106 metal binding site [ion binding]; metal-binding site 1124983000107 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124983000108 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1124983000109 DNA protecting protein DprA; Region: dprA; TIGR00732 1124983000110 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1124983000111 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1124983000112 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1124983000113 NADP binding site [chemical binding]; other site 1124983000114 dimer interface [polypeptide binding]; other site 1124983000115 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1124983000116 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1124983000117 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1124983000118 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1124983000119 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1124983000120 shikimate binding site; other site 1124983000121 NAD(P) binding site [chemical binding]; other site 1124983000122 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1124983000123 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1124983000124 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124983000125 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1124983000126 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1124983000127 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1124983000128 Sulfatase; Region: Sulfatase; cl17466 1124983000129 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1124983000130 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1124983000131 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1124983000132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983000133 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983000134 dimerization interface [polypeptide binding]; other site 1124983000135 substrate binding pocket [chemical binding]; other site 1124983000136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983000137 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1124983000138 NAD(P) binding site [chemical binding]; other site 1124983000139 active site 1124983000140 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1124983000141 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1124983000142 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1124983000143 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1124983000144 substrate binding site [chemical binding]; other site 1124983000145 active site 1124983000146 catalytic residues [active] 1124983000147 heterodimer interface [polypeptide binding]; other site 1124983000148 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1124983000149 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1124983000150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983000151 catalytic residue [active] 1124983000152 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983000153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983000154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983000155 dimerization interface [polypeptide binding]; other site 1124983000156 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1124983000157 Dodecin; Region: Dodecin; pfam07311 1124983000158 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1124983000159 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1124983000160 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1124983000161 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1124983000162 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1124983000163 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 1124983000164 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1124983000165 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1124983000166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983000167 motif II; other site 1124983000168 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1124983000169 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1124983000170 trimer interface [polypeptide binding]; other site 1124983000171 putative metal binding site [ion binding]; other site 1124983000172 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1124983000173 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1124983000174 active site 1124983000175 Zn binding site [ion binding]; other site 1124983000176 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1124983000177 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1124983000178 active site 1124983000179 catalytic residues [active] 1124983000180 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1124983000181 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1124983000182 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1124983000183 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983000184 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983000185 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983000186 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1124983000187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1124983000188 FeS/SAM binding site; other site 1124983000189 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1124983000190 active site clefts [active] 1124983000191 zinc binding site [ion binding]; other site 1124983000192 dimer interface [polypeptide binding]; other site 1124983000193 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1124983000194 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124983000195 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1124983000196 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1124983000197 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1124983000198 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983000199 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1124983000200 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1124983000201 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1124983000202 Subunit I/III interface [polypeptide binding]; other site 1124983000203 D-pathway; other site 1124983000204 Subunit I/VIIc interface [polypeptide binding]; other site 1124983000205 Subunit I/IV interface [polypeptide binding]; other site 1124983000206 Subunit I/II interface [polypeptide binding]; other site 1124983000207 Low-spin heme (heme a) binding site [chemical binding]; other site 1124983000208 Subunit I/VIIa interface [polypeptide binding]; other site 1124983000209 Subunit I/VIa interface [polypeptide binding]; other site 1124983000210 Dimer interface; other site 1124983000211 Putative water exit pathway; other site 1124983000212 Binuclear center (heme a3/CuB) [ion binding]; other site 1124983000213 K-pathway; other site 1124983000214 Subunit I/Vb interface [polypeptide binding]; other site 1124983000215 Putative proton exit pathway; other site 1124983000216 Subunit I/VIb interface; other site 1124983000217 Subunit I/VIc interface [polypeptide binding]; other site 1124983000218 Electron transfer pathway; other site 1124983000219 Subunit I/VIIIb interface [polypeptide binding]; other site 1124983000220 Subunit I/VIIb interface [polypeptide binding]; other site 1124983000221 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1124983000222 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1124983000223 Subunit III/VIIa interface [polypeptide binding]; other site 1124983000224 Phospholipid binding site [chemical binding]; other site 1124983000225 Subunit I/III interface [polypeptide binding]; other site 1124983000226 Subunit III/VIb interface [polypeptide binding]; other site 1124983000227 Subunit III/VIa interface; other site 1124983000228 Subunit III/Vb interface [polypeptide binding]; other site 1124983000229 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1124983000230 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1124983000231 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1124983000232 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1124983000233 UbiA prenyltransferase family; Region: UbiA; pfam01040 1124983000234 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1124983000235 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1124983000236 Cu(I) binding site [ion binding]; other site 1124983000237 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1124983000238 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1124983000239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000240 dimer interface [polypeptide binding]; other site 1124983000241 conserved gate region; other site 1124983000242 ABC-ATPase subunit interface; other site 1124983000243 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1124983000244 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1124983000245 Walker A/P-loop; other site 1124983000246 ATP binding site [chemical binding]; other site 1124983000247 Q-loop/lid; other site 1124983000248 ABC transporter signature motif; other site 1124983000249 Walker B; other site 1124983000250 D-loop; other site 1124983000251 H-loop/switch region; other site 1124983000252 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1124983000253 hydroperoxidase II; Provisional; Region: katE; PRK11249 1124983000254 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1124983000255 tetramer interface [polypeptide binding]; other site 1124983000256 heme binding pocket [chemical binding]; other site 1124983000257 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1124983000258 domain interactions; other site 1124983000259 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1124983000260 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1124983000261 dimer interface [polypeptide binding]; other site 1124983000262 putative PBP binding regions; other site 1124983000263 ABC-ATPase subunit interface; other site 1124983000264 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1124983000265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983000266 Walker A/P-loop; other site 1124983000267 ATP binding site [chemical binding]; other site 1124983000268 Q-loop/lid; other site 1124983000269 ABC transporter signature motif; other site 1124983000270 Walker B; other site 1124983000271 D-loop; other site 1124983000272 H-loop/switch region; other site 1124983000273 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1124983000274 metal binding site 2 [ion binding]; metal-binding site 1124983000275 putative DNA binding helix; other site 1124983000276 metal binding site 1 [ion binding]; metal-binding site 1124983000277 dimer interface [polypeptide binding]; other site 1124983000278 structural Zn2+ binding site [ion binding]; other site 1124983000279 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1124983000280 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1124983000281 metal binding site [ion binding]; metal-binding site 1124983000282 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1124983000283 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1124983000284 putative active site [active] 1124983000285 putative substrate binding site [chemical binding]; other site 1124983000286 ATP binding site [chemical binding]; other site 1124983000287 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1124983000288 DNA polymerase I; Provisional; Region: PRK05755 1124983000289 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1124983000290 active site 1124983000291 metal binding site 1 [ion binding]; metal-binding site 1124983000292 putative 5' ssDNA interaction site; other site 1124983000293 metal binding site 3; metal-binding site 1124983000294 metal binding site 2 [ion binding]; metal-binding site 1124983000295 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1124983000296 putative DNA binding site [nucleotide binding]; other site 1124983000297 putative metal binding site [ion binding]; other site 1124983000298 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1124983000299 active site 1124983000300 catalytic site [active] 1124983000301 substrate binding site [chemical binding]; other site 1124983000302 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1124983000303 active site 1124983000304 DNA binding site [nucleotide binding] 1124983000305 catalytic site [active] 1124983000306 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1124983000307 G1 box; other site 1124983000308 GTP/Mg2+ binding site [chemical binding]; other site 1124983000309 Switch I region; other site 1124983000310 G2 box; other site 1124983000311 G3 box; other site 1124983000312 Switch II region; other site 1124983000313 G4 box; other site 1124983000314 G5 box; other site 1124983000315 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1124983000316 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1124983000317 Cytochrome c; Region: Cytochrom_C; cl11414 1124983000318 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1124983000319 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1124983000320 catalytic residues [active] 1124983000321 hinge region; other site 1124983000322 alpha helical domain; other site 1124983000323 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1124983000324 putative catalytic site [active] 1124983000325 putative metal binding site [ion binding]; other site 1124983000326 putative phosphate binding site [ion binding]; other site 1124983000327 putative catalytic site [active] 1124983000328 putative phosphate binding site [ion binding]; other site 1124983000329 putative metal binding site [ion binding]; other site 1124983000330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983000331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983000332 metal binding site [ion binding]; metal-binding site 1124983000333 active site 1124983000334 I-site; other site 1124983000335 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1124983000336 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1124983000337 amidase catalytic site [active] 1124983000338 Zn binding residues [ion binding]; other site 1124983000339 substrate binding site [chemical binding]; other site 1124983000340 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1124983000341 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1124983000342 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1124983000343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983000344 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983000345 dimerization interface [polypeptide binding]; other site 1124983000346 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1124983000347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983000348 putative active site [active] 1124983000349 heme pocket [chemical binding]; other site 1124983000350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983000351 dimer interface [polypeptide binding]; other site 1124983000352 phosphorylation site [posttranslational modification] 1124983000353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983000354 ATP binding site [chemical binding]; other site 1124983000355 Mg2+ binding site [ion binding]; other site 1124983000356 G-X-G motif; other site 1124983000357 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983000358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983000359 active site 1124983000360 phosphorylation site [posttranslational modification] 1124983000361 intermolecular recognition site; other site 1124983000362 dimerization interface [polypeptide binding]; other site 1124983000363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983000364 Walker A motif; other site 1124983000365 ATP binding site [chemical binding]; other site 1124983000366 Walker B motif; other site 1124983000367 arginine finger; other site 1124983000368 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983000369 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 1124983000370 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1124983000371 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124983000372 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1124983000373 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1124983000374 Protein of unknown function (DUF330); Region: DUF330; cl01135 1124983000375 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1124983000376 mce related protein; Region: MCE; pfam02470 1124983000377 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1124983000378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983000379 Walker A/P-loop; other site 1124983000380 ATP binding site [chemical binding]; other site 1124983000381 Q-loop/lid; other site 1124983000382 ABC transporter signature motif; other site 1124983000383 Walker B; other site 1124983000384 D-loop; other site 1124983000385 H-loop/switch region; other site 1124983000386 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1124983000387 Permease; Region: Permease; pfam02405 1124983000388 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1124983000389 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1124983000390 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1124983000391 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1124983000392 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1124983000393 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1124983000394 PhoU domain; Region: PhoU; pfam01895 1124983000395 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1124983000396 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1124983000397 Citrate transporter; Region: CitMHS; pfam03600 1124983000398 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1124983000399 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1124983000400 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1124983000401 conserverd hypothetical protein; Region: TIGR02448 1124983000402 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1124983000403 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1124983000404 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1124983000405 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1124983000406 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1124983000407 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1124983000408 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1124983000409 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1124983000410 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1124983000411 ligand binding site [chemical binding]; other site 1124983000412 homodimer interface [polypeptide binding]; other site 1124983000413 NAD(P) binding site [chemical binding]; other site 1124983000414 trimer interface B [polypeptide binding]; other site 1124983000415 trimer interface A [polypeptide binding]; other site 1124983000416 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983000417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983000418 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1124983000419 dimerization interface [polypeptide binding]; other site 1124983000420 substrate binding pocket [chemical binding]; other site 1124983000421 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1124983000422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983000423 FAD binding site [chemical binding]; other site 1124983000424 substrate binding pocket [chemical binding]; other site 1124983000425 catalytic base [active] 1124983000426 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1124983000427 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1124983000428 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1124983000429 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1124983000430 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1124983000431 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983000432 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1124983000433 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983000434 N-terminal plug; other site 1124983000435 ligand-binding site [chemical binding]; other site 1124983000436 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983000437 FecR protein; Region: FecR; pfam04773 1124983000438 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1124983000439 Cache domain; Region: Cache_1; pfam02743 1124983000440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983000441 dimerization interface [polypeptide binding]; other site 1124983000442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983000443 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983000444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983000445 dimer interface [polypeptide binding]; other site 1124983000446 putative CheW interface [polypeptide binding]; other site 1124983000447 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1124983000448 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1124983000449 HAMP domain; Region: HAMP; pfam00672 1124983000450 dimerization interface [polypeptide binding]; other site 1124983000451 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983000452 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983000453 metal binding site [ion binding]; metal-binding site 1124983000454 active site 1124983000455 I-site; other site 1124983000456 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983000457 Calx-beta domain; Region: Calx-beta; cl02522 1124983000458 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1124983000459 metal ion-dependent adhesion site (MIDAS); other site 1124983000460 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1124983000461 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1124983000462 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1124983000463 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1124983000464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983000465 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1124983000466 Walker A/P-loop; other site 1124983000467 ATP binding site [chemical binding]; other site 1124983000468 Q-loop/lid; other site 1124983000469 ABC transporter signature motif; other site 1124983000470 Walker B; other site 1124983000471 D-loop; other site 1124983000472 H-loop/switch region; other site 1124983000473 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1124983000474 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983000475 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983000476 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1124983000477 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1124983000478 active site 1124983000479 iron coordination sites [ion binding]; other site 1124983000480 substrate binding pocket [chemical binding]; other site 1124983000481 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1124983000482 NMT1-like family; Region: NMT1_2; pfam13379 1124983000483 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1124983000484 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1124983000485 Walker A/P-loop; other site 1124983000486 ATP binding site [chemical binding]; other site 1124983000487 Q-loop/lid; other site 1124983000488 ABC transporter signature motif; other site 1124983000489 Walker B; other site 1124983000490 D-loop; other site 1124983000491 H-loop/switch region; other site 1124983000492 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1124983000493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000494 dimer interface [polypeptide binding]; other site 1124983000495 conserved gate region; other site 1124983000496 putative PBP binding loops; other site 1124983000497 ABC-ATPase subunit interface; other site 1124983000498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983000499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983000500 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1124983000501 putative substrate binding pocket [chemical binding]; other site 1124983000502 putative dimerization interface [polypeptide binding]; other site 1124983000503 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1124983000504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983000505 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1124983000506 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983000507 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983000508 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1124983000509 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983000510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983000511 DNA binding residues [nucleotide binding] 1124983000512 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983000513 FecR protein; Region: FecR; pfam04773 1124983000514 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983000515 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1124983000516 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983000517 N-terminal plug; other site 1124983000518 ligand-binding site [chemical binding]; other site 1124983000519 LabA_like proteins; Region: LabA_like; cd06167 1124983000520 putative metal binding site [ion binding]; other site 1124983000521 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1124983000522 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1124983000523 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1124983000524 putative deacylase active site [active] 1124983000525 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1124983000526 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1124983000527 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124983000528 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1124983000529 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1124983000530 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124983000531 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1124983000532 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1124983000533 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983000534 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983000535 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983000536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1124983000537 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1124983000538 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1124983000539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983000540 TPR motif; other site 1124983000541 binding surface 1124983000542 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1124983000543 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1124983000544 N-glycosyltransferase; Provisional; Region: PRK11204 1124983000545 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1124983000546 DXD motif; other site 1124983000547 PgaD-like protein; Region: PgaD; pfam13994 1124983000548 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1124983000549 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1124983000550 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1124983000551 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983000552 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983000553 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983000554 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983000555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983000556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983000557 non-specific DNA binding site [nucleotide binding]; other site 1124983000558 salt bridge; other site 1124983000559 sequence-specific DNA binding site [nucleotide binding]; other site 1124983000560 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1124983000561 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1124983000562 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1124983000563 substrate binding site [chemical binding]; other site 1124983000564 von Willebrand factor; Region: vWF_A; pfam12450 1124983000565 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1124983000566 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1124983000567 metal ion-dependent adhesion site (MIDAS); other site 1124983000568 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1124983000569 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1124983000570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983000571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983000572 DNA binding residues [nucleotide binding] 1124983000573 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1124983000574 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1124983000575 DNA binding residues [nucleotide binding] 1124983000576 Killing trait; Region: RebB; pfam11747 1124983000577 Killing trait; Region: RebB; pfam11747 1124983000578 Killing trait; Region: RebB; pfam11747 1124983000579 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1124983000580 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1124983000581 tetramerization interface [polypeptide binding]; other site 1124983000582 NAD(P) binding site [chemical binding]; other site 1124983000583 catalytic residues [active] 1124983000584 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1124983000585 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983000586 inhibitor-cofactor binding pocket; inhibition site 1124983000587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983000588 catalytic residue [active] 1124983000589 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983000590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983000591 active site 1124983000592 phosphorylation site [posttranslational modification] 1124983000593 intermolecular recognition site; other site 1124983000594 dimerization interface [polypeptide binding]; other site 1124983000595 HDOD domain; Region: HDOD; pfam08668 1124983000596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983000597 PAS fold; Region: PAS_3; pfam08447 1124983000598 putative active site [active] 1124983000599 heme pocket [chemical binding]; other site 1124983000600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983000601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983000602 metal binding site [ion binding]; metal-binding site 1124983000603 active site 1124983000604 I-site; other site 1124983000605 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1124983000606 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1124983000607 Di-iron ligands [ion binding]; other site 1124983000608 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1124983000609 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1124983000610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983000611 PAS domain; Region: PAS_9; pfam13426 1124983000612 putative active site [active] 1124983000613 heme pocket [chemical binding]; other site 1124983000614 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983000615 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983000616 metal binding site [ion binding]; metal-binding site 1124983000617 active site 1124983000618 I-site; other site 1124983000619 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983000620 Uncharacterized small protein [Function unknown]; Region: COG5583 1124983000621 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1124983000622 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1124983000623 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1124983000624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000625 dimer interface [polypeptide binding]; other site 1124983000626 conserved gate region; other site 1124983000627 putative PBP binding loops; other site 1124983000628 ABC-ATPase subunit interface; other site 1124983000629 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1124983000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000631 dimer interface [polypeptide binding]; other site 1124983000632 conserved gate region; other site 1124983000633 putative PBP binding loops; other site 1124983000634 ABC-ATPase subunit interface; other site 1124983000635 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1124983000636 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1124983000637 Walker A/P-loop; other site 1124983000638 ATP binding site [chemical binding]; other site 1124983000639 Q-loop/lid; other site 1124983000640 ABC transporter signature motif; other site 1124983000641 Walker B; other site 1124983000642 D-loop; other site 1124983000643 H-loop/switch region; other site 1124983000644 TOBE-like domain; Region: TOBE_3; pfam12857 1124983000645 Predicted membrane protein [Function unknown]; Region: COG4539 1124983000646 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1124983000647 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124983000648 ligand binding site [chemical binding]; other site 1124983000649 flexible hinge region; other site 1124983000650 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1124983000651 putative switch regulator; other site 1124983000652 non-specific DNA interactions [nucleotide binding]; other site 1124983000653 DNA binding site [nucleotide binding] 1124983000654 sequence specific DNA binding site [nucleotide binding]; other site 1124983000655 putative cAMP binding site [chemical binding]; other site 1124983000656 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1124983000657 active site 1124983000658 homotetramer interface [polypeptide binding]; other site 1124983000659 Domain of unknown function (DUF336); Region: DUF336; cl01249 1124983000660 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1124983000661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983000662 active site 1124983000663 phosphorylation site [posttranslational modification] 1124983000664 intermolecular recognition site; other site 1124983000665 dimerization interface [polypeptide binding]; other site 1124983000666 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983000667 DNA binding site [nucleotide binding] 1124983000668 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1124983000669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983000670 dimer interface [polypeptide binding]; other site 1124983000671 phosphorylation site [posttranslational modification] 1124983000672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983000673 ATP binding site [chemical binding]; other site 1124983000674 Mg2+ binding site [ion binding]; other site 1124983000675 G-X-G motif; other site 1124983000676 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983000677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983000678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983000679 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1124983000680 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1124983000681 Sulfatase; Region: Sulfatase; pfam00884 1124983000682 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1124983000683 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1124983000684 Walker A/P-loop; other site 1124983000685 ATP binding site [chemical binding]; other site 1124983000686 Q-loop/lid; other site 1124983000687 ABC transporter signature motif; other site 1124983000688 Walker B; other site 1124983000689 D-loop; other site 1124983000690 H-loop/switch region; other site 1124983000691 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1124983000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1124983000693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1124983000694 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1124983000695 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1124983000696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983000697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983000698 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1124983000699 dimerization interface [polypeptide binding]; other site 1124983000700 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1124983000701 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1124983000702 active site 1124983000703 iron coordination sites [ion binding]; other site 1124983000704 substrate binding pocket [chemical binding]; other site 1124983000705 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1124983000706 Sulfatase; Region: Sulfatase; cl17466 1124983000707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983000708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983000709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983000710 dimerization interface [polypeptide binding]; other site 1124983000711 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124983000712 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983000713 N-terminal plug; other site 1124983000714 ligand-binding site [chemical binding]; other site 1124983000715 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1124983000716 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1124983000717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983000718 non-specific DNA binding site [nucleotide binding]; other site 1124983000719 salt bridge; other site 1124983000720 sequence-specific DNA binding site [nucleotide binding]; other site 1124983000721 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1124983000722 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1124983000723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983000724 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1124983000725 nucleoside/Zn binding site; other site 1124983000726 dimer interface [polypeptide binding]; other site 1124983000727 catalytic motif [active] 1124983000728 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983000729 Ankyrin repeat; Region: Ank; pfam00023 1124983000730 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983000731 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1124983000732 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1124983000733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983000734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983000735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983000736 dimerization interface [polypeptide binding]; other site 1124983000737 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1124983000738 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1124983000739 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1124983000740 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1124983000741 TolR protein; Region: tolR; TIGR02801 1124983000742 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1124983000743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983000744 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1124983000745 Walker A motif; other site 1124983000746 ATP binding site [chemical binding]; other site 1124983000747 Walker B motif; other site 1124983000748 arginine finger; other site 1124983000749 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1124983000750 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1124983000751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000752 dimer interface [polypeptide binding]; other site 1124983000753 conserved gate region; other site 1124983000754 putative PBP binding loops; other site 1124983000755 ABC-ATPase subunit interface; other site 1124983000756 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983000757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000758 dimer interface [polypeptide binding]; other site 1124983000759 conserved gate region; other site 1124983000760 putative PBP binding loops; other site 1124983000761 ABC-ATPase subunit interface; other site 1124983000762 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983000763 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983000764 Walker A/P-loop; other site 1124983000765 ATP binding site [chemical binding]; other site 1124983000766 Q-loop/lid; other site 1124983000767 ABC transporter signature motif; other site 1124983000768 Walker B; other site 1124983000769 D-loop; other site 1124983000770 H-loop/switch region; other site 1124983000771 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1124983000772 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983000773 substrate binding pocket [chemical binding]; other site 1124983000774 membrane-bound complex binding site; other site 1124983000775 hinge residues; other site 1124983000776 Predicted ATPase [General function prediction only]; Region: COG4637 1124983000777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983000778 Walker A/P-loop; other site 1124983000779 ATP binding site [chemical binding]; other site 1124983000780 Q-loop/lid; other site 1124983000781 ABC transporter signature motif; other site 1124983000782 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983000783 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983000784 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983000785 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983000786 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1124983000787 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1124983000788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983000789 S-adenosylmethionine binding site [chemical binding]; other site 1124983000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000791 dimer interface [polypeptide binding]; other site 1124983000792 conserved gate region; other site 1124983000793 ABC-ATPase subunit interface; other site 1124983000794 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1124983000795 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1124983000796 Walker A/P-loop; other site 1124983000797 ATP binding site [chemical binding]; other site 1124983000798 Q-loop/lid; other site 1124983000799 ABC transporter signature motif; other site 1124983000800 Walker B; other site 1124983000801 D-loop; other site 1124983000802 H-loop/switch region; other site 1124983000803 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1124983000804 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1124983000805 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1124983000806 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1124983000807 active site 1124983000808 non-prolyl cis peptide bond; other site 1124983000809 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1124983000810 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1124983000811 Flavin binding site [chemical binding]; other site 1124983000812 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1124983000813 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1124983000814 Flavin binding site [chemical binding]; other site 1124983000815 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1124983000816 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983000817 Walker A/P-loop; other site 1124983000818 ATP binding site [chemical binding]; other site 1124983000819 Q-loop/lid; other site 1124983000820 ABC transporter signature motif; other site 1124983000821 Walker B; other site 1124983000822 D-loop; other site 1124983000823 H-loop/switch region; other site 1124983000824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000825 dimer interface [polypeptide binding]; other site 1124983000826 conserved gate region; other site 1124983000827 putative PBP binding loops; other site 1124983000828 ABC-ATPase subunit interface; other site 1124983000829 cystine transporter subunit; Provisional; Region: PRK11260 1124983000830 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983000831 substrate binding pocket [chemical binding]; other site 1124983000832 membrane-bound complex binding site; other site 1124983000833 hinge residues; other site 1124983000834 D-cysteine desulfhydrase; Validated; Region: PRK03910 1124983000835 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1124983000836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983000837 catalytic residue [active] 1124983000838 serine O-acetyltransferase; Region: cysE; TIGR01172 1124983000839 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1124983000840 trimer interface [polypeptide binding]; other site 1124983000841 active site 1124983000842 substrate binding site [chemical binding]; other site 1124983000843 CoA binding site [chemical binding]; other site 1124983000844 BCCT family transporter; Region: BCCT; cl00569 1124983000845 short chain dehydrogenase; Provisional; Region: PRK12937 1124983000846 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1124983000847 NADP binding site [chemical binding]; other site 1124983000848 homodimer interface [polypeptide binding]; other site 1124983000849 active site 1124983000850 substrate binding site [chemical binding]; other site 1124983000851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983000852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983000853 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1124983000854 putative effector binding pocket; other site 1124983000855 putative dimerization interface [polypeptide binding]; other site 1124983000856 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124983000857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124983000858 DNA binding site [nucleotide binding] 1124983000859 domain linker motif; other site 1124983000860 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1124983000861 putative ligand binding site [chemical binding]; other site 1124983000862 putative dimerization interface [polypeptide binding]; other site 1124983000863 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124983000864 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983000865 N-terminal plug; other site 1124983000866 ligand-binding site [chemical binding]; other site 1124983000867 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1124983000868 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1124983000869 active site 1124983000870 non-prolyl cis peptide bond; other site 1124983000871 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124983000872 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124983000873 active site 1124983000874 catalytic tetrad [active] 1124983000875 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1124983000876 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983000877 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983000878 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1124983000879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983000880 putative substrate translocation pore; other site 1124983000881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983000882 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1124983000883 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1124983000884 conserved cys residue [active] 1124983000885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983000886 acyl-CoA synthetase; Validated; Region: PRK05850 1124983000887 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1124983000888 acyl-activating enzyme (AAE) consensus motif; other site 1124983000889 active site 1124983000890 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1124983000891 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1124983000892 Di-iron ligands [ion binding]; other site 1124983000893 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1124983000894 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1124983000895 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1124983000896 Di-iron ligands [ion binding]; other site 1124983000897 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1124983000898 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1124983000899 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1124983000900 putative di-iron ligands [ion binding]; other site 1124983000901 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983000902 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1124983000903 Rubredoxin; Region: Rubredoxin; pfam00301 1124983000904 iron binding site [ion binding]; other site 1124983000905 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983000906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983000907 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1124983000908 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1124983000909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983000910 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124983000911 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1124983000912 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1124983000913 active site 1124983000914 iron coordination sites [ion binding]; other site 1124983000915 substrate binding pocket [chemical binding]; other site 1124983000916 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1124983000917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983000918 dimer interface [polypeptide binding]; other site 1124983000919 conserved gate region; other site 1124983000920 putative PBP binding loops; other site 1124983000921 ABC-ATPase subunit interface; other site 1124983000922 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1124983000923 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1124983000924 Walker A/P-loop; other site 1124983000925 ATP binding site [chemical binding]; other site 1124983000926 Q-loop/lid; other site 1124983000927 ABC transporter signature motif; other site 1124983000928 Walker B; other site 1124983000929 D-loop; other site 1124983000930 H-loop/switch region; other site 1124983000931 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1124983000932 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983000933 substrate binding pocket [chemical binding]; other site 1124983000934 membrane-bound complex binding site; other site 1124983000935 hinge residues; other site 1124983000936 glutamate--cysteine ligase; Provisional; Region: PRK02107 1124983000937 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124983000938 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1124983000939 CoenzymeA binding site [chemical binding]; other site 1124983000940 subunit interaction site [polypeptide binding]; other site 1124983000941 PHB binding site; other site 1124983000942 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1124983000943 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1124983000944 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1124983000945 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1124983000946 RNA binding site [nucleotide binding]; other site 1124983000947 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1124983000948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983000949 active site 1124983000950 phosphorylation site [posttranslational modification] 1124983000951 intermolecular recognition site; other site 1124983000952 dimerization interface [polypeptide binding]; other site 1124983000953 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983000954 DNA binding site [nucleotide binding] 1124983000955 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1124983000956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983000957 dimerization interface [polypeptide binding]; other site 1124983000958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983000959 ATP binding site [chemical binding]; other site 1124983000960 Mg2+ binding site [ion binding]; other site 1124983000961 G-X-G motif; other site 1124983000962 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1124983000963 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1124983000964 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1124983000965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983000966 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124983000967 RNA binding surface [nucleotide binding]; other site 1124983000968 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1124983000969 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1124983000970 dimerization interface [polypeptide binding]; other site 1124983000971 domain crossover interface; other site 1124983000972 redox-dependent activation switch; other site 1124983000973 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1124983000974 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1124983000975 active site 1124983000976 substrate-binding site [chemical binding]; other site 1124983000977 metal-binding site [ion binding] 1124983000978 ATP binding site [chemical binding]; other site 1124983000979 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1124983000980 TPR repeat; Region: TPR_11; pfam13414 1124983000981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983000982 binding surface 1124983000983 TPR motif; other site 1124983000984 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1124983000985 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1124983000986 NodB motif; other site 1124983000987 active site 1124983000988 catalytic site [active] 1124983000989 metal binding site [ion binding]; metal-binding site 1124983000990 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1124983000991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983000992 ATP binding site [chemical binding]; other site 1124983000993 putative Mg++ binding site [ion binding]; other site 1124983000994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983000995 nucleotide binding region [chemical binding]; other site 1124983000996 ATP-binding site [chemical binding]; other site 1124983000997 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1124983000998 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124983000999 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124983001000 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124983001001 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1124983001002 active site 1124983001003 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1124983001004 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1124983001005 putative molybdopterin cofactor binding site [chemical binding]; other site 1124983001006 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1124983001007 putative molybdopterin cofactor binding site; other site 1124983001008 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983001009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983001010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983001011 dimerization interface [polypeptide binding]; other site 1124983001012 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1124983001013 BON domain; Region: BON; pfam04972 1124983001014 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124983001015 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1124983001016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983001017 motif II; other site 1124983001018 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1124983001019 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1124983001020 dimer interface [polypeptide binding]; other site 1124983001021 ADP-ribose binding site [chemical binding]; other site 1124983001022 active site 1124983001023 nudix motif; other site 1124983001024 metal binding site [ion binding]; metal-binding site 1124983001025 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1124983001026 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1124983001027 active site 1124983001028 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1124983001029 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983001030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983001031 active site 1124983001032 phosphorylation site [posttranslational modification] 1124983001033 intermolecular recognition site; other site 1124983001034 dimerization interface [polypeptide binding]; other site 1124983001035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983001036 Walker A motif; other site 1124983001037 ATP binding site [chemical binding]; other site 1124983001038 Walker B motif; other site 1124983001039 arginine finger; other site 1124983001040 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1124983001041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983001042 dimer interface [polypeptide binding]; other site 1124983001043 phosphorylation site [posttranslational modification] 1124983001044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983001045 ATP binding site [chemical binding]; other site 1124983001046 G-X-G motif; other site 1124983001047 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1124983001048 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1124983001049 NADP binding site [chemical binding]; other site 1124983001050 active site 1124983001051 putative substrate binding site [chemical binding]; other site 1124983001052 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1124983001053 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1124983001054 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1124983001055 substrate binding site; other site 1124983001056 tetramer interface; other site 1124983001057 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1124983001058 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1124983001059 NAD binding site [chemical binding]; other site 1124983001060 substrate binding site [chemical binding]; other site 1124983001061 homodimer interface [polypeptide binding]; other site 1124983001062 active site 1124983001063 hypothetical protein; Provisional; Region: PRK06149 1124983001064 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1124983001065 active site 1124983001066 ATP binding site [chemical binding]; other site 1124983001067 substrate binding site [chemical binding]; other site 1124983001068 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983001069 inhibitor-cofactor binding pocket; inhibition site 1124983001070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983001071 catalytic residue [active] 1124983001072 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1124983001073 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1124983001074 putative active site; other site 1124983001075 catalytic triad [active] 1124983001076 putative dimer interface [polypeptide binding]; other site 1124983001077 agmatine deiminase; Provisional; Region: PRK13551 1124983001078 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1124983001079 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1124983001080 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983001081 N-terminal plug; other site 1124983001082 ligand-binding site [chemical binding]; other site 1124983001083 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1124983001084 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1124983001085 catalytic residues [active] 1124983001086 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1124983001087 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983001088 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1124983001089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983001090 binding surface 1124983001091 TPR motif; other site 1124983001092 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1124983001093 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1124983001094 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1124983001095 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1124983001096 active site 1124983001097 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124983001098 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1124983001099 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1124983001100 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1124983001101 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1124983001102 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983001103 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983001104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983001105 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1124983001106 agmatinase; Region: agmatinase; TIGR01230 1124983001107 oligomer interface [polypeptide binding]; other site 1124983001108 putative active site [active] 1124983001109 Mn binding site [ion binding]; other site 1124983001110 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1124983001111 Na binding site [ion binding]; other site 1124983001112 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1124983001113 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1124983001114 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983001115 catalytic loop [active] 1124983001116 iron binding site [ion binding]; other site 1124983001117 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1124983001118 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124983001119 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1124983001120 [4Fe-4S] binding site [ion binding]; other site 1124983001121 molybdopterin cofactor binding site; other site 1124983001122 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1124983001123 molybdopterin cofactor binding site; other site 1124983001124 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1124983001125 putative dimer interface [polypeptide binding]; other site 1124983001126 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1124983001127 SLBB domain; Region: SLBB; pfam10531 1124983001128 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1124983001129 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1124983001130 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1124983001131 putative dimer interface [polypeptide binding]; other site 1124983001132 [2Fe-2S] cluster binding site [ion binding]; other site 1124983001133 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124983001134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983001135 dimer interface [polypeptide binding]; other site 1124983001136 conserved gate region; other site 1124983001137 putative PBP binding loops; other site 1124983001138 ABC-ATPase subunit interface; other site 1124983001139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983001140 dimer interface [polypeptide binding]; other site 1124983001141 conserved gate region; other site 1124983001142 putative PBP binding loops; other site 1124983001143 ABC-ATPase subunit interface; other site 1124983001144 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1124983001145 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1124983001146 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1124983001147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983001148 Walker A/P-loop; other site 1124983001149 ATP binding site [chemical binding]; other site 1124983001150 Q-loop/lid; other site 1124983001151 ABC transporter signature motif; other site 1124983001152 Walker B; other site 1124983001153 D-loop; other site 1124983001154 H-loop/switch region; other site 1124983001155 TOBE domain; Region: TOBE_2; pfam08402 1124983001156 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983001157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983001158 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983001159 dimerization interface [polypeptide binding]; other site 1124983001160 substrate binding pocket [chemical binding]; other site 1124983001161 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1124983001162 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1124983001163 metal binding site [ion binding]; metal-binding site 1124983001164 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1124983001165 Berberine and berberine like; Region: BBE; pfam08031 1124983001166 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1124983001167 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983001168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983001169 dimer interface [polypeptide binding]; other site 1124983001170 conserved gate region; other site 1124983001171 putative PBP binding loops; other site 1124983001172 ABC-ATPase subunit interface; other site 1124983001173 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983001174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983001175 dimer interface [polypeptide binding]; other site 1124983001176 conserved gate region; other site 1124983001177 putative PBP binding loops; other site 1124983001178 ABC-ATPase subunit interface; other site 1124983001179 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983001180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983001181 substrate binding pocket [chemical binding]; other site 1124983001182 membrane-bound complex binding site; other site 1124983001183 hinge residues; other site 1124983001184 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1124983001185 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983001186 Walker A/P-loop; other site 1124983001187 ATP binding site [chemical binding]; other site 1124983001188 Q-loop/lid; other site 1124983001189 ABC transporter signature motif; other site 1124983001190 Walker B; other site 1124983001191 D-loop; other site 1124983001192 H-loop/switch region; other site 1124983001193 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1124983001194 Spore germination protein; Region: Spore_permease; cl17796 1124983001195 DKNYY family; Region: DKNYY; pfam13644 1124983001196 DKNYY family; Region: DKNYY; pfam13644 1124983001197 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1124983001198 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124983001199 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1124983001200 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124983001201 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1124983001202 putative active site [active] 1124983001203 putative metal binding site [ion binding]; other site 1124983001204 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1124983001205 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1124983001206 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983001207 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 1124983001208 EamA-like transporter family; Region: EamA; pfam00892 1124983001209 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983001210 EamA-like transporter family; Region: EamA; pfam00892 1124983001211 Fic family protein [Function unknown]; Region: COG3177 1124983001212 Fic/DOC family; Region: Fic; pfam02661 1124983001213 oxidative damage protection protein; Provisional; Region: PRK05408 1124983001214 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1124983001215 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1124983001216 minor groove reading motif; other site 1124983001217 helix-hairpin-helix signature motif; other site 1124983001218 substrate binding pocket [chemical binding]; other site 1124983001219 active site 1124983001220 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1124983001221 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1124983001222 DNA binding and oxoG recognition site [nucleotide binding] 1124983001223 AsmA family; Region: AsmA; pfam05170 1124983001224 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1124983001225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983001226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983001227 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1124983001228 putative active site pocket [active] 1124983001229 4-fold oligomerization interface [polypeptide binding]; other site 1124983001230 metal binding residues [ion binding]; metal-binding site 1124983001231 3-fold/trimer interface [polypeptide binding]; other site 1124983001232 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1124983001233 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1124983001234 putative active site [active] 1124983001235 oxyanion strand; other site 1124983001236 catalytic triad [active] 1124983001237 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1124983001238 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1124983001239 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1124983001240 catalytic residues [active] 1124983001241 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1124983001242 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1124983001243 substrate binding site [chemical binding]; other site 1124983001244 glutamase interaction surface [polypeptide binding]; other site 1124983001245 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983001246 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983001247 substrate binding pocket [chemical binding]; other site 1124983001248 membrane-bound complex binding site; other site 1124983001249 hinge residues; other site 1124983001250 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1124983001251 NodB motif; other site 1124983001252 putative active site [active] 1124983001253 putative catalytic site [active] 1124983001254 Zn binding site [ion binding]; other site 1124983001255 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1124983001256 C-terminal peptidase (prc); Region: prc; TIGR00225 1124983001257 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1124983001258 protein binding site [polypeptide binding]; other site 1124983001259 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1124983001260 Catalytic dyad [active] 1124983001261 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1124983001262 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124983001263 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1124983001264 phosphoglyceromutase; Provisional; Region: PRK05434 1124983001265 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1124983001266 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1124983001267 active site residue [active] 1124983001268 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1124983001269 GSH binding site [chemical binding]; other site 1124983001270 catalytic residues [active] 1124983001271 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1124983001272 SecA binding site; other site 1124983001273 Preprotein binding site; other site 1124983001274 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1124983001275 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1124983001276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983001277 active site 1124983001278 phosphorylation site [posttranslational modification] 1124983001279 intermolecular recognition site; other site 1124983001280 dimerization interface [polypeptide binding]; other site 1124983001281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983001282 Walker A motif; other site 1124983001283 ATP binding site [chemical binding]; other site 1124983001284 Walker B motif; other site 1124983001285 arginine finger; other site 1124983001286 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983001287 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1124983001288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983001289 putative active site [active] 1124983001290 heme pocket [chemical binding]; other site 1124983001291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983001292 dimer interface [polypeptide binding]; other site 1124983001293 phosphorylation site [posttranslational modification] 1124983001294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983001295 ATP binding site [chemical binding]; other site 1124983001296 Mg2+ binding site [ion binding]; other site 1124983001297 G-X-G motif; other site 1124983001298 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1124983001299 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1124983001300 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1124983001301 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1124983001302 DNA binding site [nucleotide binding] 1124983001303 active site 1124983001304 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983001305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983001306 putative substrate translocation pore; other site 1124983001307 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1124983001308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983001309 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 1124983001310 putative dimerization interface [polypeptide binding]; other site 1124983001311 putative substrate binding pocket [chemical binding]; other site 1124983001312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983001313 active site 1124983001314 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1124983001315 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1124983001316 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1124983001317 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1124983001318 chorismate mutase; Provisional; Region: PRK09269 1124983001319 Chorismate mutase type II; Region: CM_2; cl00693 1124983001320 glutamine synthetase; Provisional; Region: glnA; PRK09469 1124983001321 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1124983001322 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124983001323 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1124983001324 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1124983001325 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1124983001326 Ligand Binding Site [chemical binding]; other site 1124983001327 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 1124983001328 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1124983001329 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1124983001330 G1 box; other site 1124983001331 putative GEF interaction site [polypeptide binding]; other site 1124983001332 GTP/Mg2+ binding site [chemical binding]; other site 1124983001333 Switch I region; other site 1124983001334 G2 box; other site 1124983001335 G3 box; other site 1124983001336 Switch II region; other site 1124983001337 G4 box; other site 1124983001338 G5 box; other site 1124983001339 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1124983001340 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1124983001341 Flagellin N-methylase; Region: FliB; pfam03692 1124983001342 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1124983001343 homodimer interface [polypeptide binding]; other site 1124983001344 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1124983001345 active site pocket [active] 1124983001346 Predicted membrane protein [Function unknown]; Region: COG5373 1124983001347 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1124983001348 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1124983001349 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1124983001350 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1124983001351 AMP binding site [chemical binding]; other site 1124983001352 metal binding site [ion binding]; metal-binding site 1124983001353 active site 1124983001354 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1124983001355 Cache domain; Region: Cache_1; pfam02743 1124983001356 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983001357 dimerization interface [polypeptide binding]; other site 1124983001358 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983001359 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983001360 dimer interface [polypeptide binding]; other site 1124983001361 putative CheW interface [polypeptide binding]; other site 1124983001362 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1124983001363 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1124983001364 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1124983001365 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1124983001366 active site 1124983001367 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1124983001368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983001369 DNA-binding site [nucleotide binding]; DNA binding site 1124983001370 UTRA domain; Region: UTRA; pfam07702 1124983001371 HutD; Region: HutD; pfam05962 1124983001372 urocanate hydratase; Provisional; Region: PRK05414 1124983001373 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1124983001374 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1124983001375 Na binding site [ion binding]; other site 1124983001376 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1124983001377 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1124983001378 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1124983001379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983001380 dimer interface [polypeptide binding]; other site 1124983001381 conserved gate region; other site 1124983001382 putative PBP binding loops; other site 1124983001383 ABC-ATPase subunit interface; other site 1124983001384 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983001385 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1124983001386 Walker A/P-loop; other site 1124983001387 ATP binding site [chemical binding]; other site 1124983001388 Q-loop/lid; other site 1124983001389 ABC transporter signature motif; other site 1124983001390 Walker B; other site 1124983001391 D-loop; other site 1124983001392 H-loop/switch region; other site 1124983001393 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1124983001394 active sites [active] 1124983001395 tetramer interface [polypeptide binding]; other site 1124983001396 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1124983001397 active sites [active] 1124983001398 tetramer interface [polypeptide binding]; other site 1124983001399 putative proline-specific permease; Provisional; Region: proY; PRK10580 1124983001400 imidazolonepropionase; Validated; Region: PRK09356 1124983001401 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1124983001402 active site 1124983001403 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1124983001404 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1124983001405 TAP-like protein; Region: Abhydrolase_4; pfam08386 1124983001406 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1124983001407 putative active site [active] 1124983001408 dimerization interface [polypeptide binding]; other site 1124983001409 putative tRNAtyr binding site [nucleotide binding]; other site 1124983001410 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1124983001411 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1124983001412 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983001413 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1124983001414 Ligand binding site; other site 1124983001415 DXD motif; other site 1124983001416 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983001417 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983001418 substrate binding pocket [chemical binding]; other site 1124983001419 membrane-bound complex binding site; other site 1124983001420 hinge residues; other site 1124983001421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983001422 dimer interface [polypeptide binding]; other site 1124983001423 conserved gate region; other site 1124983001424 putative PBP binding loops; other site 1124983001425 ABC-ATPase subunit interface; other site 1124983001426 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983001427 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983001428 Walker A/P-loop; other site 1124983001429 ATP binding site [chemical binding]; other site 1124983001430 Q-loop/lid; other site 1124983001431 ABC transporter signature motif; other site 1124983001432 Walker B; other site 1124983001433 D-loop; other site 1124983001434 H-loop/switch region; other site 1124983001435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983001436 dimerization interface [polypeptide binding]; other site 1124983001437 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983001438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983001439 dimer interface [polypeptide binding]; other site 1124983001440 putative CheW interface [polypeptide binding]; other site 1124983001441 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1124983001442 RNA methyltransferase, RsmE family; Region: TIGR00046 1124983001443 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1124983001444 sec-independent translocase; Provisional; Region: tatB; PRK00404 1124983001445 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1124983001446 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 1124983001447 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 1124983001448 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1124983001449 metal binding site [ion binding]; metal-binding site 1124983001450 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1124983001451 ABC1 family; Region: ABC1; cl17513 1124983001452 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1124983001453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1124983001454 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1124983001455 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1124983001456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983001457 S-adenosylmethionine binding site [chemical binding]; other site 1124983001458 putative polyhydroxyalkanoic acid system protein; Region: PHA_gran_rgn; TIGR02610 1124983001459 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1124983001460 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1124983001461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983001462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983001463 Bacterial transcriptional repressor; Region: TetR; pfam13972 1124983001464 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1124983001465 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1124983001466 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1124983001467 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1124983001468 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1124983001469 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1124983001470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1124983001471 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1124983001472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983001473 Walker A motif; other site 1124983001474 ATP binding site [chemical binding]; other site 1124983001475 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1124983001476 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1124983001477 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1124983001478 active site 1124983001479 HslU subunit interaction site [polypeptide binding]; other site 1124983001480 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 1124983001481 Sporulation related domain; Region: SPOR; pfam05036 1124983001482 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1124983001483 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1124983001484 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1124983001485 active site 1124983001486 HIGH motif; other site 1124983001487 KMSK motif region; other site 1124983001488 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1124983001489 tRNA binding surface [nucleotide binding]; other site 1124983001490 anticodon binding site; other site 1124983001491 primosome assembly protein PriA; Validated; Region: PRK05580 1124983001492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983001493 ATP binding site [chemical binding]; other site 1124983001494 putative Mg++ binding site [ion binding]; other site 1124983001495 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1124983001496 ATP-binding site [chemical binding]; other site 1124983001497 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1124983001498 Staphylococcal nuclease homologues; Region: SNc; smart00318 1124983001499 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1124983001500 Catalytic site; other site 1124983001501 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1124983001502 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1124983001503 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1124983001504 putative NAD(P) binding site [chemical binding]; other site 1124983001505 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1124983001506 Transglycosylase; Region: Transgly; pfam00912 1124983001507 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1124983001508 Competence protein A; Region: Competence_A; pfam11104 1124983001509 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1124983001510 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1124983001511 Pilus assembly protein, PilO; Region: PilO; pfam04350 1124983001512 Pilus assembly protein, PilP; Region: PilP; pfam04351 1124983001513 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1124983001514 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983001515 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1124983001516 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1124983001517 shikimate kinase; Reviewed; Region: aroK; PRK00131 1124983001518 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1124983001519 ADP binding site [chemical binding]; other site 1124983001520 magnesium binding site [ion binding]; other site 1124983001521 putative shikimate binding site; other site 1124983001522 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1124983001523 active site 1124983001524 dimer interface [polypeptide binding]; other site 1124983001525 metal binding site [ion binding]; metal-binding site 1124983001526 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1124983001527 Sporulation related domain; Region: SPOR; pfam05036 1124983001528 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1124983001529 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1124983001530 active site 1124983001531 dimer interface [polypeptide binding]; other site 1124983001532 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1124983001533 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1124983001534 active site 1124983001535 FMN binding site [chemical binding]; other site 1124983001536 substrate binding site [chemical binding]; other site 1124983001537 3Fe-4S cluster binding site [ion binding]; other site 1124983001538 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1124983001539 domain interface; other site 1124983001540 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1124983001541 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124983001542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983001543 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1124983001544 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1124983001545 substrate binding site [chemical binding]; other site 1124983001546 active site 1124983001547 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124983001548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983001549 putative substrate translocation pore; other site 1124983001550 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1124983001551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983001552 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1124983001553 dimerization interface [polypeptide binding]; other site 1124983001554 substrate binding pocket [chemical binding]; other site 1124983001555 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1124983001556 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1124983001557 dimer interface [polypeptide binding]; other site 1124983001558 active site 1124983001559 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1124983001560 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1124983001561 NAD(P) binding site [chemical binding]; other site 1124983001562 homotetramer interface [polypeptide binding]; other site 1124983001563 homodimer interface [polypeptide binding]; other site 1124983001564 active site 1124983001565 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1124983001566 putative active site 1 [active] 1124983001567 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1124983001568 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1124983001569 dimer interface [polypeptide binding]; other site 1124983001570 active site 1124983001571 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1124983001572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983001573 S-adenosylmethionine binding site [chemical binding]; other site 1124983001574 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1124983001575 Predicted exporter [General function prediction only]; Region: COG4258 1124983001576 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1124983001577 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1124983001578 active site 1124983001579 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1124983001580 active sites [active] 1124983001581 tetramer interface [polypeptide binding]; other site 1124983001582 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1124983001583 putative acyl-acceptor binding pocket; other site 1124983001584 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1124983001585 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1124983001586 Ligand binding site; other site 1124983001587 Putative Catalytic site; other site 1124983001588 DXD motif; other site 1124983001589 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1124983001590 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983001591 AMP binding site [chemical binding]; other site 1124983001592 active site 1124983001593 acyl-activating enzyme (AAE) consensus motif; other site 1124983001594 CoA binding site [chemical binding]; other site 1124983001595 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1124983001596 active site 2 [active] 1124983001597 dimer interface [polypeptide binding]; other site 1124983001598 active site 1 [active] 1124983001599 Predicted membrane protein [Function unknown]; Region: COG4648 1124983001600 acyl carrier protein; Provisional; Region: PRK05350 1124983001601 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1124983001602 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1124983001603 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124983001604 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1124983001605 putative acyl-acceptor binding pocket; other site 1124983001606 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1124983001607 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1124983001608 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1124983001609 P-loop; other site 1124983001610 Magnesium ion binding site [ion binding]; other site 1124983001611 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1124983001612 Magnesium ion binding site [ion binding]; other site 1124983001613 thioredoxin 2; Provisional; Region: PRK10996 1124983001614 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1124983001615 catalytic residues [active] 1124983001616 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1124983001617 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1124983001618 hypothetical protein; Validated; Region: PRK00029 1124983001619 hypothetical protein; Provisional; Region: PRK11281 1124983001620 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1124983001621 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124983001622 potassium/proton antiporter; Reviewed; Region: PRK05326 1124983001623 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1124983001624 TrkA-C domain; Region: TrkA_C; pfam02080 1124983001625 Transporter associated domain; Region: CorC_HlyC; smart01091 1124983001626 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983001627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983001628 dimerization interface [polypeptide binding]; other site 1124983001629 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983001630 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983001631 dimer interface [polypeptide binding]; other site 1124983001632 putative CheW interface [polypeptide binding]; other site 1124983001633 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983001634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983001635 dimerization interface [polypeptide binding]; other site 1124983001636 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983001637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983001638 dimer interface [polypeptide binding]; other site 1124983001639 putative CheW interface [polypeptide binding]; other site 1124983001640 Cell division protein ZapA; Region: ZapA; pfam05164 1124983001641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983001642 dimerization interface [polypeptide binding]; other site 1124983001643 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983001644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983001645 dimer interface [polypeptide binding]; other site 1124983001646 putative CheW interface [polypeptide binding]; other site 1124983001647 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1124983001648 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1124983001649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983001650 active site 1124983001651 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1124983001652 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1124983001653 Predicted transcriptional regulator [Transcription]; Region: COG3905 1124983001654 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1124983001655 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1124983001656 Glutamate binding site [chemical binding]; other site 1124983001657 NAD binding site [chemical binding]; other site 1124983001658 catalytic residues [active] 1124983001659 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1124983001660 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1124983001661 Na binding site [ion binding]; other site 1124983001662 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 1124983001663 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1124983001664 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1124983001665 homodimer interface [polypeptide binding]; other site 1124983001666 substrate-cofactor binding pocket; other site 1124983001667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983001668 catalytic residue [active] 1124983001669 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1124983001670 Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794 1124983001671 N- and C-terminal domain interface [polypeptide binding]; other site 1124983001672 active site 1124983001673 MgATP binding site [chemical binding]; other site 1124983001674 catalytic site [active] 1124983001675 metal binding site [ion binding]; metal-binding site 1124983001676 putative homotetramer interface [polypeptide binding]; other site 1124983001677 putative homodimer interface [polypeptide binding]; other site 1124983001678 putative glycerol binding site [chemical binding]; other site 1124983001679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1124983001680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983001681 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1124983001682 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983001683 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1124983001684 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124983001685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983001686 putative DNA binding site [nucleotide binding]; other site 1124983001687 putative Zn2+ binding site [ion binding]; other site 1124983001688 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124983001689 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1124983001690 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 1124983001691 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1124983001692 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1124983001693 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1124983001694 GAF domain; Region: GAF; pfam01590 1124983001695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983001696 PAS domain; Region: PAS_9; pfam13426 1124983001697 putative active site [active] 1124983001698 heme pocket [chemical binding]; other site 1124983001699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983001700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983001701 metal binding site [ion binding]; metal-binding site 1124983001702 active site 1124983001703 I-site; other site 1124983001704 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983001705 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1124983001706 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124983001707 E3 interaction surface; other site 1124983001708 lipoyl attachment site [posttranslational modification]; other site 1124983001709 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124983001710 E3 interaction surface; other site 1124983001711 lipoyl attachment site [posttranslational modification]; other site 1124983001712 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124983001713 E3 interaction surface; other site 1124983001714 lipoyl attachment site [posttranslational modification]; other site 1124983001715 e3 binding domain; Region: E3_binding; pfam02817 1124983001716 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1124983001717 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1124983001718 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1124983001719 dimer interface [polypeptide binding]; other site 1124983001720 TPP-binding site [chemical binding]; other site 1124983001721 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1124983001722 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1124983001723 metal binding triad; other site 1124983001724 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1124983001725 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1124983001726 metal binding triad; other site 1124983001727 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1124983001728 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1124983001729 putative active site [active] 1124983001730 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1124983001731 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1124983001732 putative active site [active] 1124983001733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983001734 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1124983001735 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1124983001736 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1124983001737 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1124983001738 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1124983001739 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1124983001740 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1124983001741 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1124983001742 putative ADP-binding pocket [chemical binding]; other site 1124983001743 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983001744 Mig-14; Region: Mig-14; pfam07395 1124983001745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1124983001746 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1124983001747 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1124983001748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983001749 putative ADP-binding pocket [chemical binding]; other site 1124983001750 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983001751 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983001752 active site 1124983001753 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1124983001754 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1124983001755 trimer interface [polypeptide binding]; other site 1124983001756 active site 1124983001757 substrate binding site [chemical binding]; other site 1124983001758 CoA binding site [chemical binding]; other site 1124983001759 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1124983001760 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1124983001761 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1124983001762 active site 1124983001763 substrate binding site [chemical binding]; other site 1124983001764 ATP binding site [chemical binding]; other site 1124983001765 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1124983001766 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983001767 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1124983001768 Walker A/P-loop; other site 1124983001769 ATP binding site [chemical binding]; other site 1124983001770 Q-loop/lid; other site 1124983001771 ABC transporter signature motif; other site 1124983001772 Walker B; other site 1124983001773 D-loop; other site 1124983001774 H-loop/switch region; other site 1124983001775 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1124983001776 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1124983001777 ligand-binding site [chemical binding]; other site 1124983001778 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1124983001779 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1124983001780 putative ribose interaction site [chemical binding]; other site 1124983001781 putative ADP binding site [chemical binding]; other site 1124983001782 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1124983001783 active site 1124983001784 nucleotide binding site [chemical binding]; other site 1124983001785 HIGH motif; other site 1124983001786 KMSKS motif; other site 1124983001787 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124983001788 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124983001789 active site 1124983001790 catalytic tetrad [active] 1124983001791 FAD dependent oxidoreductase; Region: DAO; pfam01266 1124983001792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983001793 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1124983001794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983001795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983001796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983001797 dimerization interface [polypeptide binding]; other site 1124983001798 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1124983001799 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1124983001800 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1124983001801 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1124983001802 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1124983001803 ThiC-associated domain; Region: ThiC-associated; pfam13667 1124983001804 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1124983001805 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1124983001806 Na binding site [ion binding]; other site 1124983001807 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1124983001808 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1124983001809 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1124983001810 dimer interface [polypeptide binding]; other site 1124983001811 ADP-ribose binding site [chemical binding]; other site 1124983001812 active site 1124983001813 nudix motif; other site 1124983001814 metal binding site [ion binding]; metal-binding site 1124983001815 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 1124983001816 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1124983001817 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1124983001818 active site 1124983001819 metal binding site [ion binding]; metal-binding site 1124983001820 hexamer interface [polypeptide binding]; other site 1124983001821 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1124983001822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983001823 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1124983001824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983001825 ATP binding site [chemical binding]; other site 1124983001826 Mg2+ binding site [ion binding]; other site 1124983001827 G-X-G motif; other site 1124983001828 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1124983001829 anchoring element; other site 1124983001830 dimer interface [polypeptide binding]; other site 1124983001831 ATP binding site [chemical binding]; other site 1124983001832 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1124983001833 active site 1124983001834 metal binding site [ion binding]; metal-binding site 1124983001835 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1124983001836 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1124983001837 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1124983001838 catalytic motif [active] 1124983001839 Catalytic residue [active] 1124983001840 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1124983001841 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1124983001842 CAP-like domain; other site 1124983001843 active site 1124983001844 primary dimer interface [polypeptide binding]; other site 1124983001845 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1124983001846 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 1124983001847 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1124983001848 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1124983001849 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1124983001850 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1124983001851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983001852 motif II; other site 1124983001853 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1124983001854 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1124983001855 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1124983001856 active site residue [active] 1124983001857 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1124983001858 active site residue [active] 1124983001859 HDOD domain; Region: HDOD; pfam08668 1124983001860 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1124983001861 flagellar motor protein MotA; Validated; Region: PRK09110 1124983001862 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1124983001863 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1124983001864 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983001865 ligand binding site [chemical binding]; other site 1124983001866 GTPase RsgA; Reviewed; Region: PRK12288 1124983001867 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1124983001868 RNA binding site [nucleotide binding]; other site 1124983001869 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1124983001870 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1124983001871 GTP/Mg2+ binding site [chemical binding]; other site 1124983001872 G4 box; other site 1124983001873 G5 box; other site 1124983001874 G1 box; other site 1124983001875 Switch I region; other site 1124983001876 G2 box; other site 1124983001877 G3 box; other site 1124983001878 Switch II region; other site 1124983001879 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1124983001880 catalytic site [active] 1124983001881 putative active site [active] 1124983001882 putative substrate binding site [chemical binding]; other site 1124983001883 dimer interface [polypeptide binding]; other site 1124983001884 Predicted membrane protein [Function unknown]; Region: COG2860 1124983001885 UPF0126 domain; Region: UPF0126; pfam03458 1124983001886 UPF0126 domain; Region: UPF0126; pfam03458 1124983001887 epoxyqueuosine reductase; Region: TIGR00276 1124983001888 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1124983001889 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1124983001890 putative substrate binding site [chemical binding]; other site 1124983001891 putative ATP binding site [chemical binding]; other site 1124983001892 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1124983001893 AMIN domain; Region: AMIN; pfam11741 1124983001894 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1124983001895 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1124983001896 active site 1124983001897 metal binding site [ion binding]; metal-binding site 1124983001898 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1124983001899 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124983001900 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1124983001901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983001902 ATP binding site [chemical binding]; other site 1124983001903 Mg2+ binding site [ion binding]; other site 1124983001904 G-X-G motif; other site 1124983001905 Mitochondrial ribosomal subunit protein; Region: MRP-S28; pfam10213 1124983001906 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1124983001907 ATP binding site [chemical binding]; other site 1124983001908 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1124983001909 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1124983001910 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1124983001911 bacterial Hfq-like; Region: Hfq; cd01716 1124983001912 hexamer interface [polypeptide binding]; other site 1124983001913 Sm1 motif; other site 1124983001914 RNA binding site [nucleotide binding]; other site 1124983001915 Sm2 motif; other site 1124983001916 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1124983001917 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1124983001918 HflX GTPase family; Region: HflX; cd01878 1124983001919 G1 box; other site 1124983001920 GTP/Mg2+ binding site [chemical binding]; other site 1124983001921 Switch I region; other site 1124983001922 G2 box; other site 1124983001923 G3 box; other site 1124983001924 Switch II region; other site 1124983001925 G4 box; other site 1124983001926 G5 box; other site 1124983001927 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1124983001928 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1124983001929 HflK protein; Region: hflK; TIGR01933 1124983001930 FtsH protease regulator HflC; Provisional; Region: PRK11029 1124983001931 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1124983001932 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1124983001933 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1124983001934 dimer interface [polypeptide binding]; other site 1124983001935 motif 1; other site 1124983001936 active site 1124983001937 motif 2; other site 1124983001938 motif 3; other site 1124983001939 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1124983001940 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1124983001941 GDP-binding site [chemical binding]; other site 1124983001942 ACT binding site; other site 1124983001943 IMP binding site; other site 1124983001944 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1124983001945 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983001946 dimerization interface [polypeptide binding]; other site 1124983001947 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983001948 dimer interface [polypeptide binding]; other site 1124983001949 putative CheW interface [polypeptide binding]; other site 1124983001950 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1124983001951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983001952 dimer interface [polypeptide binding]; other site 1124983001953 conserved gate region; other site 1124983001954 putative PBP binding loops; other site 1124983001955 ABC-ATPase subunit interface; other site 1124983001956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983001957 dimer interface [polypeptide binding]; other site 1124983001958 conserved gate region; other site 1124983001959 putative PBP binding loops; other site 1124983001960 ABC-ATPase subunit interface; other site 1124983001961 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1124983001962 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124983001963 ribonuclease R; Region: RNase_R; TIGR02063 1124983001964 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1124983001965 RNB domain; Region: RNB; pfam00773 1124983001966 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1124983001967 RNA binding site [nucleotide binding]; other site 1124983001968 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1124983001969 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1124983001970 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1124983001971 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1124983001972 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1124983001973 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1124983001974 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1124983001975 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1124983001976 replicative DNA helicase; Provisional; Region: PRK05748 1124983001977 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1124983001978 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1124983001979 Walker A motif; other site 1124983001980 ATP binding site [chemical binding]; other site 1124983001981 Walker B motif; other site 1124983001982 DNA binding loops [nucleotide binding] 1124983001983 hypothetical protein; Provisional; Region: PRK01254 1124983001984 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1124983001985 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1124983001986 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1124983001987 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1124983001988 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1124983001989 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1124983001990 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1124983001991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1124983001992 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1124983001993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1124983001994 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1124983001995 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1124983001996 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1124983001997 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1124983001998 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1124983001999 azurin; Region: azurin; TIGR02695 1124983002000 NAD synthase; Region: NAD_synthase; pfam02540 1124983002001 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1124983002002 homodimer interface [polypeptide binding]; other site 1124983002003 NAD binding pocket [chemical binding]; other site 1124983002004 ATP binding pocket [chemical binding]; other site 1124983002005 Mg binding site [ion binding]; other site 1124983002006 active-site loop [active] 1124983002007 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1124983002008 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1124983002009 active site 1124983002010 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983002011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983002012 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983002013 dimerization interface [polypeptide binding]; other site 1124983002014 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1124983002015 aldehyde dehydrogenase family 7 member; Region: PLN02315 1124983002016 tetrameric interface [polypeptide binding]; other site 1124983002017 NAD binding site [chemical binding]; other site 1124983002018 catalytic residues [active] 1124983002019 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983002020 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983002021 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1124983002022 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1124983002023 dimerization interface [polypeptide binding]; other site 1124983002024 ligand binding site [chemical binding]; other site 1124983002025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124983002026 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1124983002027 TM-ABC transporter signature motif; other site 1124983002028 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1124983002029 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1124983002030 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1124983002031 TM-ABC transporter signature motif; other site 1124983002032 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1124983002033 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1124983002034 Walker A/P-loop; other site 1124983002035 ATP binding site [chemical binding]; other site 1124983002036 Q-loop/lid; other site 1124983002037 ABC transporter signature motif; other site 1124983002038 Walker B; other site 1124983002039 D-loop; other site 1124983002040 H-loop/switch region; other site 1124983002041 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1124983002042 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1124983002043 Walker A/P-loop; other site 1124983002044 ATP binding site [chemical binding]; other site 1124983002045 Q-loop/lid; other site 1124983002046 ABC transporter signature motif; other site 1124983002047 Walker B; other site 1124983002048 D-loop; other site 1124983002049 H-loop/switch region; other site 1124983002050 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1124983002051 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1124983002052 putative NAD(P) binding site [chemical binding]; other site 1124983002053 homotetramer interface [polypeptide binding]; other site 1124983002054 homodimer interface [polypeptide binding]; other site 1124983002055 active site 1124983002056 Cation efflux family; Region: Cation_efflux; cl00316 1124983002057 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1124983002058 putative active cleft [active] 1124983002059 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1124983002060 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1124983002061 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1124983002062 UreF; Region: UreF; pfam01730 1124983002063 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1124983002064 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1124983002065 dimer interface [polypeptide binding]; other site 1124983002066 catalytic residues [active] 1124983002067 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1124983002068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983002069 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1124983002070 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1124983002071 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1124983002072 Ferritin-like domain; Region: Ferritin; pfam00210 1124983002073 dinuclear metal binding motif [ion binding]; other site 1124983002074 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983002075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983002076 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983002077 dimerization interface [polypeptide binding]; other site 1124983002078 substrate binding pocket [chemical binding]; other site 1124983002079 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1124983002080 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983002081 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1124983002082 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1124983002083 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1124983002084 EamA-like transporter family; Region: EamA; pfam00892 1124983002085 EamA-like transporter family; Region: EamA; pfam00892 1124983002086 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983002087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983002088 hypothetical protein; Provisional; Region: PRK11505 1124983002089 psiF repeat; Region: PsiF_repeat; pfam07769 1124983002090 psiF repeat; Region: PsiF_repeat; pfam07769 1124983002091 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1124983002092 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1124983002093 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1124983002094 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1124983002095 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1124983002096 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983002097 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983002098 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983002099 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983002100 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983002101 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1124983002102 putative chaperone; Provisional; Region: PRK11678 1124983002103 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1124983002104 nucleotide binding site [chemical binding]; other site 1124983002105 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1124983002106 SBD interface [polypeptide binding]; other site 1124983002107 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1124983002108 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124983002109 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1124983002110 substrate binding site [polypeptide binding]; other site 1124983002111 dimer interface [polypeptide binding]; other site 1124983002112 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1124983002113 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1124983002114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983002115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983002116 dimer interface [polypeptide binding]; other site 1124983002117 phosphorylation site [posttranslational modification] 1124983002118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983002119 ATP binding site [chemical binding]; other site 1124983002120 Mg2+ binding site [ion binding]; other site 1124983002121 G-X-G motif; other site 1124983002122 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1124983002123 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1124983002124 subunit interactions [polypeptide binding]; other site 1124983002125 active site 1124983002126 flap region; other site 1124983002127 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1124983002128 gamma-beta subunit interface [polypeptide binding]; other site 1124983002129 alpha-beta subunit interface [polypeptide binding]; other site 1124983002130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983002131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983002132 Coenzyme A binding pocket [chemical binding]; other site 1124983002133 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1124983002134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983002135 Coenzyme A binding pocket [chemical binding]; other site 1124983002136 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1124983002137 alpha-gamma subunit interface [polypeptide binding]; other site 1124983002138 beta-gamma subunit interface [polypeptide binding]; other site 1124983002139 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1124983002140 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1124983002141 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1124983002142 Walker A/P-loop; other site 1124983002143 ATP binding site [chemical binding]; other site 1124983002144 Q-loop/lid; other site 1124983002145 ABC transporter signature motif; other site 1124983002146 Walker B; other site 1124983002147 D-loop; other site 1124983002148 H-loop/switch region; other site 1124983002149 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1124983002150 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1124983002151 Walker A/P-loop; other site 1124983002152 ATP binding site [chemical binding]; other site 1124983002153 Q-loop/lid; other site 1124983002154 ABC transporter signature motif; other site 1124983002155 Walker B; other site 1124983002156 D-loop; other site 1124983002157 H-loop/switch region; other site 1124983002158 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1124983002159 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1124983002160 TM-ABC transporter signature motif; other site 1124983002161 HEAT repeats; Region: HEAT_2; pfam13646 1124983002162 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1124983002163 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124983002164 TM-ABC transporter signature motif; other site 1124983002165 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1124983002166 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1124983002167 putative ligand binding site [chemical binding]; other site 1124983002168 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1124983002169 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124983002170 ABC-ATPase subunit interface; other site 1124983002171 dimer interface [polypeptide binding]; other site 1124983002172 putative PBP binding regions; other site 1124983002173 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1124983002174 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1124983002175 putative ligand binding residues [chemical binding]; other site 1124983002176 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1124983002177 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1124983002178 Walker A/P-loop; other site 1124983002179 ATP binding site [chemical binding]; other site 1124983002180 Q-loop/lid; other site 1124983002181 ABC transporter signature motif; other site 1124983002182 Walker B; other site 1124983002183 D-loop; other site 1124983002184 H-loop/switch region; other site 1124983002185 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983002186 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983002187 N-terminal plug; other site 1124983002188 ligand-binding site [chemical binding]; other site 1124983002189 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1124983002190 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1124983002191 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1124983002192 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1124983002193 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1124983002194 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983002195 N-terminal plug; other site 1124983002196 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1124983002197 ligand-binding site [chemical binding]; other site 1124983002198 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1124983002199 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1124983002200 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1124983002201 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1124983002202 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1124983002203 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1124983002204 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1124983002205 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1124983002206 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1124983002207 active site 1124983002208 putative homodimer interface [polypeptide binding]; other site 1124983002209 SAM binding site [chemical binding]; other site 1124983002210 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1124983002211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983002212 S-adenosylmethionine binding site [chemical binding]; other site 1124983002213 precorrin-3B synthase; Region: CobG; TIGR02435 1124983002214 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124983002215 Colon cancer-associated protein Mic1-like; Region: Mic1; pfam07035 1124983002216 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124983002217 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1124983002218 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1124983002219 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1124983002220 active site 1124983002221 SAM binding site [chemical binding]; other site 1124983002222 homodimer interface [polypeptide binding]; other site 1124983002223 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1124983002224 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1124983002225 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1124983002226 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1124983002227 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1124983002228 active site 1124983002229 SAM binding site [chemical binding]; other site 1124983002230 homodimer interface [polypeptide binding]; other site 1124983002231 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1124983002232 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1124983002233 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1124983002234 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1124983002235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983002236 dimer interface [polypeptide binding]; other site 1124983002237 phosphorylation site [posttranslational modification] 1124983002238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983002239 ATP binding site [chemical binding]; other site 1124983002240 Mg2+ binding site [ion binding]; other site 1124983002241 G-X-G motif; other site 1124983002242 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983002243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983002244 active site 1124983002245 phosphorylation site [posttranslational modification] 1124983002246 intermolecular recognition site; other site 1124983002247 dimerization interface [polypeptide binding]; other site 1124983002248 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983002249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983002250 active site 1124983002251 phosphorylation site [posttranslational modification] 1124983002252 intermolecular recognition site; other site 1124983002253 dimerization interface [polypeptide binding]; other site 1124983002254 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1124983002255 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1124983002256 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1124983002257 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1124983002258 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1124983002259 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1124983002260 purine monophosphate binding site [chemical binding]; other site 1124983002261 dimer interface [polypeptide binding]; other site 1124983002262 putative catalytic residues [active] 1124983002263 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1124983002264 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1124983002265 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1124983002266 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1124983002267 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1124983002268 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1124983002269 FMN binding site [chemical binding]; other site 1124983002270 active site 1124983002271 catalytic residues [active] 1124983002272 substrate binding site [chemical binding]; other site 1124983002273 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1124983002274 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1124983002275 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1124983002276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1124983002277 S-adenosylmethionine binding site [chemical binding]; other site 1124983002278 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1124983002279 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124983002280 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1124983002281 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1124983002282 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1124983002283 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124983002284 carboxyltransferase (CT) interaction site; other site 1124983002285 biotinylation site [posttranslational modification]; other site 1124983002286 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1124983002287 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1124983002288 active site 1124983002289 trimer interface [polypeptide binding]; other site 1124983002290 dimer interface [polypeptide binding]; other site 1124983002291 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983002292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983002293 dimer interface [polypeptide binding]; other site 1124983002294 putative CheW interface [polypeptide binding]; other site 1124983002295 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1124983002296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983002297 active site 1124983002298 phosphorylation site [posttranslational modification] 1124983002299 intermolecular recognition site; other site 1124983002300 dimerization interface [polypeptide binding]; other site 1124983002301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983002302 metal binding site [ion binding]; metal-binding site 1124983002303 active site 1124983002304 I-site; other site 1124983002305 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1124983002306 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1124983002307 nudix motif; other site 1124983002308 translation initiation factor Sui1; Validated; Region: PRK06824 1124983002309 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1124983002310 putative rRNA binding site [nucleotide binding]; other site 1124983002311 arginine decarboxylase; Provisional; Region: PRK05354 1124983002312 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1124983002313 dimer interface [polypeptide binding]; other site 1124983002314 active site 1124983002315 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983002316 catalytic residues [active] 1124983002317 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1124983002318 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1124983002319 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1124983002320 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1124983002321 homodimer interface [polypeptide binding]; other site 1124983002322 chemical substrate binding site [chemical binding]; other site 1124983002323 oligomer interface [polypeptide binding]; other site 1124983002324 metal binding site [ion binding]; metal-binding site 1124983002325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983002326 S-adenosylmethionine binding site [chemical binding]; other site 1124983002327 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1124983002328 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1124983002329 Predicted membrane protein [Function unknown]; Region: COG4655 1124983002330 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 1124983002331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983002332 PAS fold; Region: PAS_3; pfam08447 1124983002333 putative active site [active] 1124983002334 heme pocket [chemical binding]; other site 1124983002335 PAS domain; Region: PAS; smart00091 1124983002336 PAS fold; Region: PAS_4; pfam08448 1124983002337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983002338 dimer interface [polypeptide binding]; other site 1124983002339 phosphorylation site [posttranslational modification] 1124983002340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983002341 ATP binding site [chemical binding]; other site 1124983002342 Mg2+ binding site [ion binding]; other site 1124983002343 G-X-G motif; other site 1124983002344 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1124983002345 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983002346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983002347 active site 1124983002348 phosphorylation site [posttranslational modification] 1124983002349 intermolecular recognition site; other site 1124983002350 dimerization interface [polypeptide binding]; other site 1124983002351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983002352 DNA binding residues [nucleotide binding] 1124983002353 dimerization interface [polypeptide binding]; other site 1124983002354 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1124983002355 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1124983002356 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1124983002357 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1124983002358 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124983002359 YtxC-like family; Region: YtxC; cl08500 1124983002360 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1124983002361 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1124983002362 ATP binding site [chemical binding]; other site 1124983002363 Walker A motif; other site 1124983002364 hexamer interface [polypeptide binding]; other site 1124983002365 Walker B motif; other site 1124983002366 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1124983002367 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1124983002368 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1124983002369 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1124983002370 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 1124983002371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983002372 active site 1124983002373 phosphorylation site [posttranslational modification] 1124983002374 intermolecular recognition site; other site 1124983002375 dimerization interface [polypeptide binding]; other site 1124983002376 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1124983002377 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1124983002378 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1124983002379 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1124983002380 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1124983002381 active site 2 [active] 1124983002382 active site 1 [active] 1124983002383 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1124983002384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983002385 NAD(P) binding site [chemical binding]; other site 1124983002386 active site 1124983002387 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1124983002388 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983002389 dimer interface [polypeptide binding]; other site 1124983002390 active site 1124983002391 Cache domain; Region: Cache_1; pfam02743 1124983002392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983002393 dimerization interface [polypeptide binding]; other site 1124983002394 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983002395 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983002396 dimer interface [polypeptide binding]; other site 1124983002397 putative CheW interface [polypeptide binding]; other site 1124983002398 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 1124983002399 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1124983002400 ATP binding site [chemical binding]; other site 1124983002401 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1124983002402 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1124983002403 DNA binding residues [nucleotide binding] 1124983002404 dimer interface [polypeptide binding]; other site 1124983002405 copper binding site [ion binding]; other site 1124983002406 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1124983002407 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124983002408 metal-binding site [ion binding] 1124983002409 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1124983002410 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124983002411 metal-binding site [ion binding] 1124983002412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124983002413 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124983002414 metal-binding site [ion binding] 1124983002415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983002416 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1124983002417 putative substrate translocation pore; other site 1124983002418 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1124983002419 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1124983002420 putative NAD(P) binding site [chemical binding]; other site 1124983002421 dimer interface [polypeptide binding]; other site 1124983002422 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1124983002423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983002424 transcriptional activator TtdR; Provisional; Region: PRK09801 1124983002425 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983002426 putative effector binding pocket; other site 1124983002427 dimerization interface [polypeptide binding]; other site 1124983002428 benzoate transport; Region: 2A0115; TIGR00895 1124983002429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983002430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983002431 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1124983002432 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1124983002433 active site 1124983002434 purine riboside binding site [chemical binding]; other site 1124983002435 oxidase reductase; Provisional; Region: PTZ00273 1124983002436 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1124983002437 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1124983002438 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1124983002439 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1124983002440 putative ligand binding site [chemical binding]; other site 1124983002441 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1124983002442 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1124983002443 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1124983002444 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1124983002445 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1124983002446 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1124983002447 active site 1124983002448 putative substrate binding pocket [chemical binding]; other site 1124983002449 short chain dehydrogenase; Provisional; Region: PRK08177 1124983002450 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1124983002451 NAD(P) binding site [chemical binding]; other site 1124983002452 active site 1124983002453 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1124983002454 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124983002455 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1124983002456 TM-ABC transporter signature motif; other site 1124983002457 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124983002458 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1124983002459 TM-ABC transporter signature motif; other site 1124983002460 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1124983002461 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1124983002462 Walker A/P-loop; other site 1124983002463 ATP binding site [chemical binding]; other site 1124983002464 Q-loop/lid; other site 1124983002465 ABC transporter signature motif; other site 1124983002466 Walker B; other site 1124983002467 D-loop; other site 1124983002468 H-loop/switch region; other site 1124983002469 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1124983002470 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1124983002471 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1124983002472 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1124983002473 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1124983002474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983002475 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1124983002476 xanthine permease; Region: pbuX; TIGR03173 1124983002477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983002478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983002479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983002480 dimerization interface [polypeptide binding]; other site 1124983002481 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1124983002482 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983002483 inhibitor-cofactor binding pocket; inhibition site 1124983002484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983002485 catalytic residue [active] 1124983002486 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1124983002487 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1124983002488 tetrameric interface [polypeptide binding]; other site 1124983002489 NAD binding site [chemical binding]; other site 1124983002490 catalytic residues [active] 1124983002491 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1124983002492 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1124983002493 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1124983002494 Part of AAA domain; Region: AAA_19; pfam13245 1124983002495 Family description; Region: UvrD_C_2; pfam13538 1124983002496 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1124983002497 AAA domain; Region: AAA_30; pfam13604 1124983002498 Family description; Region: UvrD_C_2; pfam13538 1124983002499 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1124983002500 HAMP domain; Region: HAMP; pfam00672 1124983002501 dimerization interface [polypeptide binding]; other site 1124983002502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983002503 metal binding site [ion binding]; metal-binding site 1124983002504 active site 1124983002505 I-site; other site 1124983002506 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1124983002507 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983002508 ligand binding site [chemical binding]; other site 1124983002509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983002510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983002511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983002512 dimerization interface [polypeptide binding]; other site 1124983002513 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1124983002514 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1124983002515 tetrameric interface [polypeptide binding]; other site 1124983002516 NAD binding site [chemical binding]; other site 1124983002517 catalytic residues [active] 1124983002518 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124983002519 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1124983002520 RES domain; Region: RES; cl02411 1124983002521 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1124983002522 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1124983002523 arylformamidase; Region: trp_arylform; TIGR03035 1124983002524 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1124983002525 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983002526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983002527 DNA-binding site [nucleotide binding]; DNA binding site 1124983002528 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983002529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983002530 homodimer interface [polypeptide binding]; other site 1124983002531 catalytic residue [active] 1124983002532 benzoate transporter; Region: benE; TIGR00843 1124983002533 Benzoate membrane transport protein; Region: BenE; pfam03594 1124983002534 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1124983002535 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1124983002536 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983002537 catalytic loop [active] 1124983002538 iron binding site [ion binding]; other site 1124983002539 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1124983002540 FAD binding pocket [chemical binding]; other site 1124983002541 FAD binding motif [chemical binding]; other site 1124983002542 phosphate binding motif [ion binding]; other site 1124983002543 beta-alpha-beta structure motif; other site 1124983002544 NAD binding pocket [chemical binding]; other site 1124983002545 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1124983002546 inter-subunit interface; other site 1124983002547 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 1124983002548 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1124983002549 [2Fe-2S] cluster binding site [ion binding]; other site 1124983002550 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1124983002551 putative alpha subunit interface [polypeptide binding]; other site 1124983002552 putative active site [active] 1124983002553 putative substrate binding site [chemical binding]; other site 1124983002554 Fe binding site [ion binding]; other site 1124983002555 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983002556 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983002557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983002558 putative DNA binding site [nucleotide binding]; other site 1124983002559 putative Zn2+ binding site [ion binding]; other site 1124983002560 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983002561 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1124983002562 kynureninase; Region: kynureninase; TIGR01814 1124983002563 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983002564 catalytic residue [active] 1124983002565 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1124983002566 Spore germination protein; Region: Spore_permease; cl17796 1124983002567 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1124983002568 DNA binding residues [nucleotide binding] 1124983002569 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1124983002570 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1124983002571 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983002572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983002573 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1124983002574 putative dimerization interface [polypeptide binding]; other site 1124983002575 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1124983002576 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1124983002577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983002578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983002579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983002580 dimerization interface [polypeptide binding]; other site 1124983002581 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1124983002582 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1124983002583 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1124983002584 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1124983002585 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124983002586 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1124983002587 GntP family permease; Region: GntP_permease; pfam02447 1124983002588 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1124983002589 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1124983002590 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124983002591 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124983002592 putative active site [active] 1124983002593 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1124983002594 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1124983002595 active site 1124983002596 putative substrate binding pocket [chemical binding]; other site 1124983002597 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1124983002598 dimer interface [polypeptide binding]; other site 1124983002599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124983002600 ligand binding site [chemical binding]; other site 1124983002601 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983002602 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983002603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983002604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983002605 dimerization interface [polypeptide binding]; other site 1124983002606 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983002607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983002608 dimer interface [polypeptide binding]; other site 1124983002609 putative CheW interface [polypeptide binding]; other site 1124983002610 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1124983002611 catalytic core [active] 1124983002612 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1124983002613 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1124983002614 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1124983002615 Predicted transcriptional regulators [Transcription]; Region: COG1733 1124983002616 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1124983002617 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1124983002618 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1124983002619 putative NAD(P) binding site [chemical binding]; other site 1124983002620 dimer interface [polypeptide binding]; other site 1124983002621 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983002622 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983002623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983002624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983002625 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1124983002626 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1124983002627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983002628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983002629 Coenzyme A binding pocket [chemical binding]; other site 1124983002630 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1124983002631 homotrimer interaction site [polypeptide binding]; other site 1124983002632 putative active site [active] 1124983002633 Protein of unknown function (DUF3726); Region: DUF3726; pfam12525 1124983002634 BCCT family transporter; Region: BCCT; pfam02028 1124983002635 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1124983002636 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1124983002637 active site 1124983002638 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1124983002639 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983002640 NAD(P) binding site [chemical binding]; other site 1124983002641 catalytic residues [active] 1124983002642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983002643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983002644 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1124983002645 putative dimerization interface [polypeptide binding]; other site 1124983002646 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1124983002647 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1124983002648 homotrimer interaction site [polypeptide binding]; other site 1124983002649 putative active site [active] 1124983002650 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983002651 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983002652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983002653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983002654 non-specific DNA binding site [nucleotide binding]; other site 1124983002655 salt bridge; other site 1124983002656 sequence-specific DNA binding site [nucleotide binding]; other site 1124983002657 Cupin domain; Region: Cupin_2; pfam07883 1124983002658 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983002659 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983002660 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983002661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983002662 Cupin domain; Region: Cupin_2; pfam07883 1124983002663 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1124983002664 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1124983002665 putative NADP binding site [chemical binding]; other site 1124983002666 putative substrate binding site [chemical binding]; other site 1124983002667 active site 1124983002668 SnoaL-like domain; Region: SnoaL_2; pfam12680 1124983002669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983002670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983002671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983002672 dimerization interface [polypeptide binding]; other site 1124983002673 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1124983002674 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983002675 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124983002676 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1124983002677 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1124983002678 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1124983002679 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1124983002680 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1124983002681 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1124983002682 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1124983002683 Cysteine-rich domain; Region: CCG; pfam02754 1124983002684 Cysteine-rich domain; Region: CCG; pfam02754 1124983002685 glycolate transporter; Provisional; Region: PRK09695 1124983002686 L-lactate permease; Region: Lactate_perm; cl00701 1124983002687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983002688 DNA-binding site [nucleotide binding]; DNA binding site 1124983002689 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124983002690 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1124983002691 Na2 binding site [ion binding]; other site 1124983002692 putative substrate binding site 1 [chemical binding]; other site 1124983002693 Na binding site 1 [ion binding]; other site 1124983002694 putative substrate binding site 2 [chemical binding]; other site 1124983002695 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1124983002696 putative coenzyme Q binding site [chemical binding]; other site 1124983002697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 1124983002698 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1124983002699 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1124983002700 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1124983002701 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1124983002702 metal binding site 2 [ion binding]; metal-binding site 1124983002703 putative DNA binding helix; other site 1124983002704 metal binding site 1 [ion binding]; metal-binding site 1124983002705 dimer interface [polypeptide binding]; other site 1124983002706 structural Zn2+ binding site [ion binding]; other site 1124983002707 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1124983002708 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1124983002709 Walker A/P-loop; other site 1124983002710 ATP binding site [chemical binding]; other site 1124983002711 Q-loop/lid; other site 1124983002712 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1124983002713 ABC transporter signature motif; other site 1124983002714 Walker B; other site 1124983002715 D-loop; other site 1124983002716 H-loop/switch region; other site 1124983002717 GrpE; Region: GrpE; pfam01025 1124983002718 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1124983002719 dimer interface [polypeptide binding]; other site 1124983002720 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1124983002721 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1124983002722 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1124983002723 nucleotide binding site [chemical binding]; other site 1124983002724 chaperone protein DnaJ; Provisional; Region: PRK10767 1124983002725 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124983002726 HSP70 interaction site [polypeptide binding]; other site 1124983002727 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1124983002728 substrate binding site [polypeptide binding]; other site 1124983002729 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1124983002730 Zn binding sites [ion binding]; other site 1124983002731 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1124983002732 dimer interface [polypeptide binding]; other site 1124983002733 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1124983002734 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1124983002735 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1124983002736 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1124983002737 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1124983002738 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1124983002739 catalytic site [active] 1124983002740 subunit interface [polypeptide binding]; other site 1124983002741 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1124983002742 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124983002743 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1124983002744 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1124983002745 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124983002746 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1124983002747 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1124983002748 IMP binding site; other site 1124983002749 dimer interface [polypeptide binding]; other site 1124983002750 interdomain contacts; other site 1124983002751 partial ornithine binding site; other site 1124983002752 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1124983002753 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1124983002754 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124983002755 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1124983002756 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1124983002757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983002758 S-adenosylmethionine binding site [chemical binding]; other site 1124983002759 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1124983002760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983002761 Walker A motif; other site 1124983002762 ATP binding site [chemical binding]; other site 1124983002763 Walker B motif; other site 1124983002764 arginine finger; other site 1124983002765 Peptidase family M41; Region: Peptidase_M41; pfam01434 1124983002766 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1124983002767 dihydropteroate synthase; Region: DHPS; TIGR01496 1124983002768 substrate binding pocket [chemical binding]; other site 1124983002769 dimer interface [polypeptide binding]; other site 1124983002770 inhibitor binding site; inhibition site 1124983002771 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1124983002772 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1124983002773 active site 1124983002774 substrate binding site [chemical binding]; other site 1124983002775 metal binding site [ion binding]; metal-binding site 1124983002776 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1124983002777 triosephosphate isomerase; Provisional; Region: PRK14567 1124983002778 substrate binding site [chemical binding]; other site 1124983002779 dimer interface [polypeptide binding]; other site 1124983002780 catalytic triad [active] 1124983002781 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1124983002782 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1124983002783 Sm and related proteins; Region: Sm_like; cl00259 1124983002784 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1124983002785 putative oligomer interface [polypeptide binding]; other site 1124983002786 putative RNA binding site [nucleotide binding]; other site 1124983002787 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1124983002788 NusA N-terminal domain; Region: NusA_N; pfam08529 1124983002789 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1124983002790 RNA binding site [nucleotide binding]; other site 1124983002791 homodimer interface [polypeptide binding]; other site 1124983002792 NusA-like KH domain; Region: KH_5; pfam13184 1124983002793 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1124983002794 G-X-X-G motif; other site 1124983002795 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1124983002796 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1124983002797 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1124983002798 translation initiation factor IF-2; Region: IF-2; TIGR00487 1124983002799 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1124983002800 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1124983002801 G1 box; other site 1124983002802 putative GEF interaction site [polypeptide binding]; other site 1124983002803 GTP/Mg2+ binding site [chemical binding]; other site 1124983002804 Switch I region; other site 1124983002805 G2 box; other site 1124983002806 G3 box; other site 1124983002807 Switch II region; other site 1124983002808 G4 box; other site 1124983002809 G5 box; other site 1124983002810 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1124983002811 Translation-initiation factor 2; Region: IF-2; pfam11987 1124983002812 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1124983002813 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1124983002814 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1124983002815 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1124983002816 RNA binding site [nucleotide binding]; other site 1124983002817 active site 1124983002818 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1124983002819 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1124983002820 16S/18S rRNA binding site [nucleotide binding]; other site 1124983002821 S13e-L30e interaction site [polypeptide binding]; other site 1124983002822 25S rRNA binding site [nucleotide binding]; other site 1124983002823 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1124983002824 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1124983002825 RNase E interface [polypeptide binding]; other site 1124983002826 trimer interface [polypeptide binding]; other site 1124983002827 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1124983002828 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1124983002829 RNase E interface [polypeptide binding]; other site 1124983002830 trimer interface [polypeptide binding]; other site 1124983002831 active site 1124983002832 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1124983002833 putative nucleic acid binding region [nucleotide binding]; other site 1124983002834 G-X-X-G motif; other site 1124983002835 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1124983002836 RNA binding site [nucleotide binding]; other site 1124983002837 domain interface; other site 1124983002838 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1124983002839 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1124983002840 dimerization interface [polypeptide binding]; other site 1124983002841 active site 1124983002842 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1124983002843 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1124983002844 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1124983002845 amidase catalytic site [active] 1124983002846 Zn binding residues [ion binding]; other site 1124983002847 substrate binding site [chemical binding]; other site 1124983002848 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1124983002849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983002850 dimerization interface [polypeptide binding]; other site 1124983002851 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983002852 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983002853 dimer interface [polypeptide binding]; other site 1124983002854 putative CheW interface [polypeptide binding]; other site 1124983002855 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1124983002856 active site 1124983002857 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1124983002858 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124983002859 DNA binding site [nucleotide binding] 1124983002860 domain linker motif; other site 1124983002861 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1124983002862 dimerization interface [polypeptide binding]; other site 1124983002863 ligand binding site [chemical binding]; other site 1124983002864 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124983002865 active site 1124983002866 phosphorylation site [posttranslational modification] 1124983002867 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1124983002868 active site 1124983002869 phosphorylation site [posttranslational modification] 1124983002870 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1124983002871 regulatory protein interface [polypeptide binding]; other site 1124983002872 active site 1124983002873 regulatory phosphorylation site [posttranslational modification]; other site 1124983002874 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1124983002875 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1124983002876 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1124983002877 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1124983002878 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1124983002879 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1124983002880 putative substrate binding site [chemical binding]; other site 1124983002881 putative ATP binding site [chemical binding]; other site 1124983002882 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1124983002883 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1124983002884 active site 1124983002885 P-loop; other site 1124983002886 phosphorylation site [posttranslational modification] 1124983002887 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1124983002888 active site 1124983002889 P-loop; other site 1124983002890 phosphorylation site [posttranslational modification] 1124983002891 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1124983002892 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1124983002893 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1124983002894 putative active site [active] 1124983002895 putative metal binding site [ion binding]; other site 1124983002896 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1124983002897 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1124983002898 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1124983002899 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1124983002900 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1124983002901 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1124983002902 Flavodoxin; Region: Flavodoxin_1; pfam00258 1124983002903 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1124983002904 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1124983002905 FAD binding pocket [chemical binding]; other site 1124983002906 FAD binding motif [chemical binding]; other site 1124983002907 catalytic residues [active] 1124983002908 NAD binding pocket [chemical binding]; other site 1124983002909 phosphate binding motif [ion binding]; other site 1124983002910 beta-alpha-beta structure motif; other site 1124983002911 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1124983002912 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983002913 N-terminal plug; other site 1124983002914 ligand-binding site [chemical binding]; other site 1124983002915 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1124983002916 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124983002917 Sel1-like repeats; Region: SEL1; smart00671 1124983002918 Sel1-like repeats; Region: SEL1; smart00671 1124983002919 Sel1-like repeats; Region: SEL1; smart00671 1124983002920 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1124983002921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1124983002922 dimer interface [polypeptide binding]; other site 1124983002923 active site 1124983002924 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983002925 catalytic residues [active] 1124983002926 substrate binding site [chemical binding]; other site 1124983002927 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1124983002928 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1124983002929 Walker A/P-loop; other site 1124983002930 ATP binding site [chemical binding]; other site 1124983002931 Q-loop/lid; other site 1124983002932 ABC transporter signature motif; other site 1124983002933 Walker B; other site 1124983002934 D-loop; other site 1124983002935 H-loop/switch region; other site 1124983002936 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1124983002937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983002938 dimer interface [polypeptide binding]; other site 1124983002939 conserved gate region; other site 1124983002940 ABC-ATPase subunit interface; other site 1124983002941 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1124983002942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983002943 ABC-ATPase subunit interface; other site 1124983002944 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1124983002945 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1124983002946 G1 box; other site 1124983002947 putative GEF interaction site [polypeptide binding]; other site 1124983002948 GTP/Mg2+ binding site [chemical binding]; other site 1124983002949 Switch I region; other site 1124983002950 G2 box; other site 1124983002951 G3 box; other site 1124983002952 Switch II region; other site 1124983002953 G4 box; other site 1124983002954 G5 box; other site 1124983002955 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1124983002956 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1124983002957 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983002958 Walker A/P-loop; other site 1124983002959 ATP binding site [chemical binding]; other site 1124983002960 Q-loop/lid; other site 1124983002961 ABC transporter signature motif; other site 1124983002962 Walker B; other site 1124983002963 D-loop; other site 1124983002964 H-loop/switch region; other site 1124983002965 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1124983002966 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1124983002967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983002968 Walker A/P-loop; other site 1124983002969 ATP binding site [chemical binding]; other site 1124983002970 Q-loop/lid; other site 1124983002971 ABC transporter signature motif; other site 1124983002972 Walker B; other site 1124983002973 D-loop; other site 1124983002974 H-loop/switch region; other site 1124983002975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983002976 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1124983002977 dipeptide transporter; Provisional; Region: PRK10913 1124983002978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983002979 dimer interface [polypeptide binding]; other site 1124983002980 conserved gate region; other site 1124983002981 putative PBP binding loops; other site 1124983002982 ABC-ATPase subunit interface; other site 1124983002983 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1124983002984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983002985 dimer interface [polypeptide binding]; other site 1124983002986 conserved gate region; other site 1124983002987 putative PBP binding loops; other site 1124983002988 ABC-ATPase subunit interface; other site 1124983002989 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1124983002990 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1124983002991 peptide binding site [polypeptide binding]; other site 1124983002992 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983002993 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1124983002994 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1124983002995 peptide binding site [polypeptide binding]; other site 1124983002996 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1124983002997 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1124983002998 peptide binding site [polypeptide binding]; other site 1124983002999 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1124983003000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983003001 non-specific DNA binding site [nucleotide binding]; other site 1124983003002 salt bridge; other site 1124983003003 sequence-specific DNA binding site [nucleotide binding]; other site 1124983003004 Cupin domain; Region: Cupin_2; pfam07883 1124983003005 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1124983003006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983003007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983003008 ATP binding site [chemical binding]; other site 1124983003009 G-X-G motif; other site 1124983003010 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1124983003011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983003012 active site 1124983003013 phosphorylation site [posttranslational modification] 1124983003014 intermolecular recognition site; other site 1124983003015 dimerization interface [polypeptide binding]; other site 1124983003016 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983003017 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1124983003018 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1124983003019 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1124983003020 Predicted permeases [General function prediction only]; Region: COG0679 1124983003021 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1124983003022 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1124983003023 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1124983003024 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1124983003025 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1124983003026 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1124983003027 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1124983003028 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1124983003029 GatB domain; Region: GatB_Yqey; smart00845 1124983003030 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1124983003031 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1124983003032 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1124983003033 rod shape-determining protein MreB; Provisional; Region: PRK13927 1124983003034 MreB and similar proteins; Region: MreB_like; cd10225 1124983003035 nucleotide binding site [chemical binding]; other site 1124983003036 Mg binding site [ion binding]; other site 1124983003037 putative protofilament interaction site [polypeptide binding]; other site 1124983003038 RodZ interaction site [polypeptide binding]; other site 1124983003039 rod shape-determining protein MreC; Provisional; Region: PRK13922 1124983003040 rod shape-determining protein MreC; Region: MreC; pfam04085 1124983003041 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1124983003042 Maf-like protein; Region: Maf; pfam02545 1124983003043 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1124983003044 active site 1124983003045 dimer interface [polypeptide binding]; other site 1124983003046 ribonuclease G; Provisional; Region: PRK11712 1124983003047 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1124983003048 homodimer interface [polypeptide binding]; other site 1124983003049 oligonucleotide binding site [chemical binding]; other site 1124983003050 TIGR02099 family protein; Region: TIGR02099 1124983003051 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1124983003052 nitrilase; Region: PLN02798 1124983003053 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1124983003054 putative active site [active] 1124983003055 catalytic triad [active] 1124983003056 dimer interface [polypeptide binding]; other site 1124983003057 protease TldD; Provisional; Region: tldD; PRK10735 1124983003058 hypothetical protein; Provisional; Region: PRK05255 1124983003059 peptidase PmbA; Provisional; Region: PRK11040 1124983003060 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1124983003061 Class II fumarases; Region: Fumarase_classII; cd01362 1124983003062 active site 1124983003063 tetramer interface [polypeptide binding]; other site 1124983003064 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 1124983003065 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1124983003066 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1124983003067 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1124983003068 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1124983003069 ZIP Zinc transporter; Region: Zip; pfam02535 1124983003070 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1124983003071 dimerization domain swap beta strand [polypeptide binding]; other site 1124983003072 regulatory protein interface [polypeptide binding]; other site 1124983003073 active site 1124983003074 regulatory phosphorylation site [posttranslational modification]; other site 1124983003075 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1124983003076 AAA domain; Region: AAA_18; pfam13238 1124983003077 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124983003078 active site 1124983003079 phosphorylation site [posttranslational modification] 1124983003080 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1124983003081 30S subunit binding site; other site 1124983003082 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1124983003083 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1124983003084 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1124983003085 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1124983003086 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1124983003087 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1124983003088 Walker A/P-loop; other site 1124983003089 ATP binding site [chemical binding]; other site 1124983003090 Q-loop/lid; other site 1124983003091 ABC transporter signature motif; other site 1124983003092 Walker B; other site 1124983003093 D-loop; other site 1124983003094 H-loop/switch region; other site 1124983003095 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1124983003096 OstA-like protein; Region: OstA; pfam03968 1124983003097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1124983003098 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1124983003099 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1124983003100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983003101 active site 1124983003102 motif I; other site 1124983003103 motif II; other site 1124983003104 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1124983003105 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1124983003106 putative active site [active] 1124983003107 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1124983003108 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1124983003109 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1124983003110 Walker A/P-loop; other site 1124983003111 ATP binding site [chemical binding]; other site 1124983003112 Q-loop/lid; other site 1124983003113 ABC transporter signature motif; other site 1124983003114 Walker B; other site 1124983003115 D-loop; other site 1124983003116 H-loop/switch region; other site 1124983003117 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1124983003118 Permease; Region: Permease; cl00510 1124983003119 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1124983003120 mce related protein; Region: MCE; pfam02470 1124983003121 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1124983003122 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1124983003123 anti sigma factor interaction site; other site 1124983003124 regulatory phosphorylation site [posttranslational modification]; other site 1124983003125 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1124983003126 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1124983003127 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1124983003128 hinge; other site 1124983003129 active site 1124983003130 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1124983003131 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1124983003132 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1124983003133 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1124983003134 NAD binding site [chemical binding]; other site 1124983003135 dimerization interface [polypeptide binding]; other site 1124983003136 product binding site; other site 1124983003137 substrate binding site [chemical binding]; other site 1124983003138 zinc binding site [ion binding]; other site 1124983003139 catalytic residues [active] 1124983003140 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1124983003141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983003142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983003143 homodimer interface [polypeptide binding]; other site 1124983003144 catalytic residue [active] 1124983003145 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1124983003146 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983003147 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983003148 N-terminal plug; other site 1124983003149 ligand-binding site [chemical binding]; other site 1124983003150 serine endoprotease; Provisional; Region: PRK10898 1124983003151 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1124983003152 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1124983003153 protein binding site [polypeptide binding]; other site 1124983003154 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1124983003155 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1124983003156 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1124983003157 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1124983003158 Active Sites [active] 1124983003159 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1124983003160 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1124983003161 CysD dimerization site [polypeptide binding]; other site 1124983003162 G1 box; other site 1124983003163 putative GEF interaction site [polypeptide binding]; other site 1124983003164 GTP/Mg2+ binding site [chemical binding]; other site 1124983003165 Switch I region; other site 1124983003166 G2 box; other site 1124983003167 G3 box; other site 1124983003168 Switch II region; other site 1124983003169 G4 box; other site 1124983003170 G5 box; other site 1124983003171 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1124983003172 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1124983003173 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1124983003174 ligand-binding site [chemical binding]; other site 1124983003175 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124983003176 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1124983003177 putative acyl-acceptor binding pocket; other site 1124983003178 phosphate acetyltransferase; Reviewed; Region: PRK05632 1124983003179 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1124983003180 DRTGG domain; Region: DRTGG; pfam07085 1124983003181 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1124983003182 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 1124983003183 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1124983003184 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124983003185 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1124983003186 catalytic residues [active] 1124983003187 dimer interface [polypeptide binding]; other site 1124983003188 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1124983003189 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1124983003190 putative active site [active] 1124983003191 putative FMN binding site [chemical binding]; other site 1124983003192 putative substrate binding site [chemical binding]; other site 1124983003193 putative catalytic residue [active] 1124983003194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983003195 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1124983003196 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1124983003197 thioredoxin reductase; Provisional; Region: PRK10262 1124983003198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983003199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983003200 HopJ type III effector protein; Region: HopJ; pfam08888 1124983003201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1124983003202 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 1124983003203 active site 1124983003204 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1124983003205 homodecamer interface [polypeptide binding]; other site 1124983003206 GTP cyclohydrolase I; Provisional; Region: PLN03044 1124983003207 active site 1124983003208 putative catalytic site residues [active] 1124983003209 zinc binding site [ion binding]; other site 1124983003210 GTP-CH-I/GFRP interaction surface; other site 1124983003211 dihydromonapterin reductase; Provisional; Region: PRK06483 1124983003212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983003213 NAD(P) binding site [chemical binding]; other site 1124983003214 active site 1124983003215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1124983003216 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1124983003217 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1124983003218 DNA binding residues [nucleotide binding] 1124983003219 B12 binding domain; Region: B12-binding_2; cl03653 1124983003220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983003221 PAS domain; Region: PAS_9; pfam13426 1124983003222 putative active site [active] 1124983003223 heme pocket [chemical binding]; other site 1124983003224 flavodoxin; Provisional; Region: PRK05723 1124983003225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983003226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983003227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983003228 dimerization interface [polypeptide binding]; other site 1124983003229 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1124983003230 LrgB-like family; Region: LrgB; pfam04172 1124983003231 aldolase II superfamily protein; Provisional; Region: PRK07044 1124983003232 intersubunit interface [polypeptide binding]; other site 1124983003233 active site 1124983003234 Zn2+ binding site [ion binding]; other site 1124983003235 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983003236 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1124983003237 homodimer interface [polypeptide binding]; other site 1124983003238 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1124983003239 NAD binding site [chemical binding]; other site 1124983003240 active site 1124983003241 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1124983003242 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1124983003243 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1124983003244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983003245 dimerization interface [polypeptide binding]; other site 1124983003246 DNA binding residues [nucleotide binding] 1124983003247 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124983003248 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124983003249 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124983003250 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1124983003251 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1124983003252 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1124983003253 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1124983003254 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1124983003255 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1124983003256 C-terminal domain interface [polypeptide binding]; other site 1124983003257 GSH binding site (G-site) [chemical binding]; other site 1124983003258 putative dimer interface [polypeptide binding]; other site 1124983003259 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1124983003260 dimer interface [polypeptide binding]; other site 1124983003261 N-terminal domain interface [polypeptide binding]; other site 1124983003262 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1124983003263 benzoate transport; Region: 2A0115; TIGR00895 1124983003264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983003265 putative substrate translocation pore; other site 1124983003266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983003267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983003268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983003269 Coenzyme A binding pocket [chemical binding]; other site 1124983003270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1124983003271 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1124983003272 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1124983003273 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1124983003274 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1124983003275 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1124983003276 NAD binding site [chemical binding]; other site 1124983003277 Phe binding site; other site 1124983003278 YebG protein; Region: YebG; pfam07130 1124983003279 Predicted membrane protein [Function unknown]; Region: COG3223 1124983003280 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1124983003281 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1124983003282 serine transporter; Region: stp; TIGR00814 1124983003283 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1124983003284 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1124983003285 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1124983003286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983003287 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983003288 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983003289 dimerization interface [polypeptide binding]; other site 1124983003290 substrate binding pocket [chemical binding]; other site 1124983003291 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1124983003292 30S subunit binding site; other site 1124983003293 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1124983003294 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983003295 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983003296 N-terminal plug; other site 1124983003297 ligand-binding site [chemical binding]; other site 1124983003298 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983003299 FecR protein; Region: FecR; pfam04773 1124983003300 RNA polymerase sigma factor; Provisional; Region: PRK12528 1124983003301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983003302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983003303 DNA binding residues [nucleotide binding] 1124983003304 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1124983003305 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1124983003306 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1124983003307 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1124983003308 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1124983003309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983003310 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983003311 DNA binding residues [nucleotide binding] 1124983003312 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983003313 FecR protein; Region: FecR; pfam04773 1124983003314 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1124983003315 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1124983003316 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1124983003317 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124983003318 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983003319 N-terminal plug; other site 1124983003320 ligand-binding site [chemical binding]; other site 1124983003321 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1124983003322 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1124983003323 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1124983003324 putative active site [active] 1124983003325 putative metal binding site [ion binding]; other site 1124983003326 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1124983003327 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983003328 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983003329 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983003330 N-terminal plug; other site 1124983003331 ligand-binding site [chemical binding]; other site 1124983003332 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1124983003333 structural tetrad; other site 1124983003334 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1124983003335 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1124983003336 active site 1124983003337 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124983003338 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983003339 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983003340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983003341 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983003342 EamA-like transporter family; Region: EamA; pfam00892 1124983003343 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1124983003344 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1124983003345 dimerization interface [polypeptide binding]; other site 1124983003346 ligand binding site [chemical binding]; other site 1124983003347 NADP binding site [chemical binding]; other site 1124983003348 catalytic site [active] 1124983003349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983003350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983003351 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983003352 putative effector binding pocket; other site 1124983003353 dimerization interface [polypeptide binding]; other site 1124983003354 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983003355 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1124983003356 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124983003357 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1124983003358 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1124983003359 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983003360 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983003361 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124983003362 short chain dehydrogenase; Provisional; Region: PRK05693 1124983003363 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1124983003364 NADP binding site [chemical binding]; other site 1124983003365 active site 1124983003366 steroid binding site; other site 1124983003367 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1124983003368 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1124983003369 Substrate binding site; other site 1124983003370 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1124983003371 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1124983003372 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1124983003373 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1124983003374 active site 1124983003375 Right handed beta helix region; Region: Beta_helix; pfam13229 1124983003376 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1124983003377 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124983003378 PilZ domain; Region: PilZ; pfam07238 1124983003379 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983003380 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983003381 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1124983003382 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1124983003383 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1124983003384 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1124983003385 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1124983003386 hypothetical protein; Validated; Region: PRK02101 1124983003387 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1124983003388 NodB motif; other site 1124983003389 active site 1124983003390 catalytic site [active] 1124983003391 metal binding site [ion binding]; metal-binding site 1124983003392 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1124983003393 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1124983003394 putative active site [active] 1124983003395 PhoH-like protein; Region: PhoH; pfam02562 1124983003396 multidrug efflux protein; Reviewed; Region: PRK09579 1124983003397 Protein export membrane protein; Region: SecD_SecF; cl14618 1124983003398 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983003399 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983003400 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983003401 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124983003402 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 1124983003403 putative metal binding site [ion binding]; other site 1124983003404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983003405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983003406 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 1124983003407 putative substrate binding pocket [chemical binding]; other site 1124983003408 putative dimerization interface [polypeptide binding]; other site 1124983003409 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1124983003410 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1124983003411 catalytic motif [active] 1124983003412 Zn binding site [ion binding]; other site 1124983003413 RibD C-terminal domain; Region: RibD_C; cl17279 1124983003414 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1124983003415 structural tetrad; other site 1124983003416 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1124983003417 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1124983003418 structural tetrad; other site 1124983003419 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1124983003420 dimerization interface [polypeptide binding]; other site 1124983003421 active site 1124983003422 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1124983003423 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1124983003424 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1124983003425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983003426 S-adenosylmethionine binding site [chemical binding]; other site 1124983003427 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1124983003428 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1124983003429 trimer interface [polypeptide binding]; other site 1124983003430 dimer interface [polypeptide binding]; other site 1124983003431 putative active site [active] 1124983003432 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1124983003433 MoaE interaction surface [polypeptide binding]; other site 1124983003434 MoeB interaction surface [polypeptide binding]; other site 1124983003435 thiocarboxylated glycine; other site 1124983003436 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1124983003437 MoaE homodimer interface [polypeptide binding]; other site 1124983003438 MoaD interaction [polypeptide binding]; other site 1124983003439 active site residues [active] 1124983003440 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1124983003441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983003442 substrate binding pocket [chemical binding]; other site 1124983003443 membrane-bound complex binding site; other site 1124983003444 hinge residues; other site 1124983003445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1124983003446 YheO-like PAS domain; Region: PAS_6; pfam08348 1124983003447 HTH domain; Region: HTH_22; pfam13309 1124983003448 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983003449 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983003450 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1124983003451 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1124983003452 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1124983003453 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124983003454 ATP binding site [chemical binding]; other site 1124983003455 Mg++ binding site [ion binding]; other site 1124983003456 motif III; other site 1124983003457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983003458 nucleotide binding region [chemical binding]; other site 1124983003459 ATP-binding site [chemical binding]; other site 1124983003460 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1124983003461 putative hydrolase; Provisional; Region: PRK11460 1124983003462 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1124983003463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983003464 substrate binding pocket [chemical binding]; other site 1124983003465 membrane-bound complex binding site; other site 1124983003466 hinge residues; other site 1124983003467 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1124983003468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983003469 conserved gate region; other site 1124983003470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983003471 dimer interface [polypeptide binding]; other site 1124983003472 ABC-ATPase subunit interface; other site 1124983003473 putative PBP binding loops; other site 1124983003474 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983003475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983003476 dimer interface [polypeptide binding]; other site 1124983003477 conserved gate region; other site 1124983003478 putative PBP binding loops; other site 1124983003479 ABC-ATPase subunit interface; other site 1124983003480 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983003481 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983003482 Walker A/P-loop; other site 1124983003483 ATP binding site [chemical binding]; other site 1124983003484 Q-loop/lid; other site 1124983003485 ABC transporter signature motif; other site 1124983003486 Walker B; other site 1124983003487 D-loop; other site 1124983003488 H-loop/switch region; other site 1124983003489 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1124983003490 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 1124983003491 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 1124983003492 peptide binding site [polypeptide binding]; other site 1124983003493 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124983003494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983003495 DNA-binding site [nucleotide binding]; DNA binding site 1124983003496 FCD domain; Region: FCD; pfam07729 1124983003497 cyanate transporter; Region: CynX; TIGR00896 1124983003498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983003499 putative substrate translocation pore; other site 1124983003500 SnoaL-like domain; Region: SnoaL_3; pfam13474 1124983003501 SnoaL-like domain; Region: SnoaL_2; pfam12680 1124983003502 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1124983003503 GIY-YIG motif/motif A; other site 1124983003504 putative active site [active] 1124983003505 putative metal binding site [ion binding]; other site 1124983003506 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983003507 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1124983003508 C-terminal domain interface [polypeptide binding]; other site 1124983003509 GSH binding site (G-site) [chemical binding]; other site 1124983003510 dimer interface [polypeptide binding]; other site 1124983003511 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1124983003512 substrate binding pocket (H-site) [chemical binding]; other site 1124983003513 N-terminal domain interface [polypeptide binding]; other site 1124983003514 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1124983003515 catalytic residues [active] 1124983003516 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1124983003517 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1124983003518 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124983003519 IHF - DNA interface [nucleotide binding]; other site 1124983003520 IHF dimer interface [polypeptide binding]; other site 1124983003521 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1124983003522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983003523 S-adenosylmethionine binding site [chemical binding]; other site 1124983003524 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1124983003525 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1124983003526 HIGH motif; other site 1124983003527 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1124983003528 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1124983003529 active site 1124983003530 KMSKS motif; other site 1124983003531 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1124983003532 tRNA binding surface [nucleotide binding]; other site 1124983003533 anticodon binding site; other site 1124983003534 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1124983003535 DNA polymerase III subunit chi; Validated; Region: PRK05728 1124983003536 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1124983003537 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1124983003538 interface (dimer of trimers) [polypeptide binding]; other site 1124983003539 Substrate-binding/catalytic site; other site 1124983003540 Zn-binding sites [ion binding]; other site 1124983003541 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1124983003542 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1124983003543 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1124983003544 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1124983003545 GTP-binding protein LepA; Provisional; Region: PRK05433 1124983003546 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1124983003547 G1 box; other site 1124983003548 putative GEF interaction site [polypeptide binding]; other site 1124983003549 GTP/Mg2+ binding site [chemical binding]; other site 1124983003550 Switch I region; other site 1124983003551 G2 box; other site 1124983003552 G3 box; other site 1124983003553 Switch II region; other site 1124983003554 G4 box; other site 1124983003555 G5 box; other site 1124983003556 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1124983003557 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1124983003558 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1124983003559 signal peptidase I; Provisional; Region: PRK10861 1124983003560 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1124983003561 Catalytic site [active] 1124983003562 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1124983003563 ribonuclease III; Reviewed; Region: rnc; PRK00102 1124983003564 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1124983003565 dimerization interface [polypeptide binding]; other site 1124983003566 active site 1124983003567 metal binding site [ion binding]; metal-binding site 1124983003568 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1124983003569 dsRNA binding site [nucleotide binding]; other site 1124983003570 GTPase Era; Reviewed; Region: era; PRK00089 1124983003571 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1124983003572 G1 box; other site 1124983003573 GTP/Mg2+ binding site [chemical binding]; other site 1124983003574 Switch I region; other site 1124983003575 G2 box; other site 1124983003576 Switch II region; other site 1124983003577 G3 box; other site 1124983003578 G4 box; other site 1124983003579 G5 box; other site 1124983003580 KH domain; Region: KH_2; pfam07650 1124983003581 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1124983003582 Recombination protein O N terminal; Region: RecO_N; pfam11967 1124983003583 Recombination protein O C terminal; Region: RecO_C; pfam02565 1124983003584 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1124983003585 active site 1124983003586 hydrophilic channel; other site 1124983003587 dimerization interface [polypeptide binding]; other site 1124983003588 catalytic residues [active] 1124983003589 active site lid [active] 1124983003590 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1124983003591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983003592 substrate binding pocket [chemical binding]; other site 1124983003593 membrane-bound complex binding site; other site 1124983003594 hinge residues; other site 1124983003595 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124983003596 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124983003597 catalytic residue [active] 1124983003598 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1124983003599 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1124983003600 dimerization interface [polypeptide binding]; other site 1124983003601 ATP binding site [chemical binding]; other site 1124983003602 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1124983003603 dimerization interface [polypeptide binding]; other site 1124983003604 ATP binding site [chemical binding]; other site 1124983003605 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1124983003606 putative active site [active] 1124983003607 catalytic triad [active] 1124983003608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1124983003609 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1124983003610 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1124983003611 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1124983003612 active site turn [active] 1124983003613 phosphorylation site [posttranslational modification] 1124983003614 phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367 1124983003615 active site turn [active] 1124983003616 phosphorylation site [posttranslational modification] 1124983003617 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1124983003618 HPr interaction site; other site 1124983003619 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1124983003620 active site 1124983003621 phosphorylation site [posttranslational modification] 1124983003622 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1124983003623 dimerization domain swap beta strand [polypeptide binding]; other site 1124983003624 regulatory protein interface [polypeptide binding]; other site 1124983003625 active site 1124983003626 regulatory phosphorylation site [posttranslational modification]; other site 1124983003627 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1124983003628 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1124983003629 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1124983003630 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1124983003631 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1124983003632 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1124983003633 dimer interface [polypeptide binding]; other site 1124983003634 active site 1124983003635 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1124983003636 dimer interface [polypeptide binding]; other site 1124983003637 active site 1124983003638 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1124983003639 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1124983003640 active site 1124983003641 dimer interface [polypeptide binding]; other site 1124983003642 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1124983003643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983003644 DNA-binding site [nucleotide binding]; DNA binding site 1124983003645 UTRA domain; Region: UTRA; pfam07702 1124983003646 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124983003647 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1124983003648 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1124983003649 nudix motif; other site 1124983003650 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1124983003651 putative active site [active] 1124983003652 putative CoA binding site [chemical binding]; other site 1124983003653 nudix motif; other site 1124983003654 metal binding site [ion binding]; metal-binding site 1124983003655 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1124983003656 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1124983003657 trimer interface [polypeptide binding]; other site 1124983003658 putative metal binding site [ion binding]; other site 1124983003659 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1124983003660 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1124983003661 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1124983003662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983003663 ATP-grasp domain; Region: ATP-grasp; pfam02222 1124983003664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983003665 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983003666 putative substrate translocation pore; other site 1124983003667 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1124983003668 Domain of unknown function DUF21; Region: DUF21; pfam01595 1124983003669 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124983003670 Transporter associated domain; Region: CorC_HlyC; smart01091 1124983003671 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1124983003672 signal recognition particle protein; Provisional; Region: PRK10867 1124983003673 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1124983003674 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1124983003675 P loop; other site 1124983003676 GTP binding site [chemical binding]; other site 1124983003677 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1124983003678 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1124983003679 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1124983003680 RimM N-terminal domain; Region: RimM; pfam01782 1124983003681 PRC-barrel domain; Region: PRC; pfam05239 1124983003682 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1124983003683 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1124983003684 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1124983003685 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1124983003686 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1124983003687 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1124983003688 TrkA-N domain; Region: TrkA_N; pfam02254 1124983003689 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1124983003690 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1124983003691 active site 1124983003692 Int/Topo IB signature motif; other site 1124983003693 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1124983003694 dimerization domain [polypeptide binding]; other site 1124983003695 dimer interface [polypeptide binding]; other site 1124983003696 catalytic residues [active] 1124983003697 homoserine dehydrogenase; Provisional; Region: PRK06349 1124983003698 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1124983003699 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1124983003700 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1124983003701 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1124983003702 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1124983003703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983003704 catalytic residue [active] 1124983003705 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1124983003706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983003707 substrate binding pocket [chemical binding]; other site 1124983003708 membrane-bound complex binding site; other site 1124983003709 hinge residues; other site 1124983003710 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983003711 substrate binding pocket [chemical binding]; other site 1124983003712 membrane-bound complex binding site; other site 1124983003713 hinge residues; other site 1124983003714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983003715 putative active site [active] 1124983003716 heme pocket [chemical binding]; other site 1124983003717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983003718 dimer interface [polypeptide binding]; other site 1124983003719 phosphorylation site [posttranslational modification] 1124983003720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983003721 ATP binding site [chemical binding]; other site 1124983003722 Mg2+ binding site [ion binding]; other site 1124983003723 G-X-G motif; other site 1124983003724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983003725 active site 1124983003726 phosphorylation site [posttranslational modification] 1124983003727 intermolecular recognition site; other site 1124983003728 dimerization interface [polypeptide binding]; other site 1124983003729 Hpt domain; Region: Hpt; pfam01627 1124983003730 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983003731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983003732 active site 1124983003733 phosphorylation site [posttranslational modification] 1124983003734 intermolecular recognition site; other site 1124983003735 dimerization interface [polypeptide binding]; other site 1124983003736 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983003737 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983003738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983003739 active site 1124983003740 phosphorylation site [posttranslational modification] 1124983003741 intermolecular recognition site; other site 1124983003742 dimerization interface [polypeptide binding]; other site 1124983003743 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983003744 DNA binding residues [nucleotide binding] 1124983003745 dimerization interface [polypeptide binding]; other site 1124983003746 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1124983003747 conserved hypothetical protein; Region: TIGR02285 1124983003748 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1124983003749 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1124983003750 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 1124983003751 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1124983003752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1124983003753 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1124983003754 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1124983003755 AAA domain; Region: AAA_22; pfam13401 1124983003756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983003757 Walker A motif; other site 1124983003758 ATP binding site [chemical binding]; other site 1124983003759 Walker B motif; other site 1124983003760 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 1124983003761 PLD-like domain; Region: PLDc_2; pfam13091 1124983003762 putative active site [active] 1124983003763 catalytic site [active] 1124983003764 replication factor C large subunit; Provisional; Region: PRK04195 1124983003765 YaeQ protein; Region: YaeQ; pfam07152 1124983003766 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1124983003767 DHH family; Region: DHH; pfam01368 1124983003768 DHHA1 domain; Region: DHHA1; pfam02272 1124983003769 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1124983003770 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1124983003771 active site 1124983003772 FMN binding site [chemical binding]; other site 1124983003773 substrate binding site [chemical binding]; other site 1124983003774 homotetramer interface [polypeptide binding]; other site 1124983003775 catalytic residue [active] 1124983003776 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1124983003777 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1124983003778 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1124983003779 Coenzyme A binding pocket [chemical binding]; other site 1124983003780 Predicted membrane protein [Function unknown]; Region: COG2311 1124983003781 Protein of unknown function (DUF418); Region: DUF418; cl12135 1124983003782 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1124983003783 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1124983003784 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1124983003785 putative metal binding site [ion binding]; other site 1124983003786 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983003787 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983003788 dimerization interface [polypeptide binding]; other site 1124983003789 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983003790 dimer interface [polypeptide binding]; other site 1124983003791 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1124983003792 putative CheW interface [polypeptide binding]; other site 1124983003793 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1124983003794 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1124983003795 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1124983003796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983003797 S-adenosylmethionine binding site [chemical binding]; other site 1124983003798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983003799 TPR motif; other site 1124983003800 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1124983003801 binding surface 1124983003802 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1124983003803 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983003804 putative binding surface; other site 1124983003805 active site 1124983003806 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1124983003807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983003808 ATP binding site [chemical binding]; other site 1124983003809 Mg2+ binding site [ion binding]; other site 1124983003810 G-X-G motif; other site 1124983003811 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1124983003812 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983003813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983003814 active site 1124983003815 phosphorylation site [posttranslational modification] 1124983003816 intermolecular recognition site; other site 1124983003817 dimerization interface [polypeptide binding]; other site 1124983003818 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1124983003819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983003820 active site 1124983003821 phosphorylation site [posttranslational modification] 1124983003822 intermolecular recognition site; other site 1124983003823 CheB methylesterase; Region: CheB_methylest; pfam01339 1124983003824 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983003825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983003826 active site 1124983003827 phosphorylation site [posttranslational modification] 1124983003828 intermolecular recognition site; other site 1124983003829 dimerization interface [polypeptide binding]; other site 1124983003830 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983003831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983003832 metal binding site [ion binding]; metal-binding site 1124983003833 active site 1124983003834 I-site; other site 1124983003835 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1124983003836 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1124983003837 RF-1 domain; Region: RF-1; pfam00472 1124983003838 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1124983003839 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1124983003840 dimer interface [polypeptide binding]; other site 1124983003841 putative anticodon binding site; other site 1124983003842 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1124983003843 motif 1; other site 1124983003844 active site 1124983003845 motif 2; other site 1124983003846 motif 3; other site 1124983003847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1124983003848 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1124983003849 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983003850 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983003851 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124983003852 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983003853 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983003854 ligand binding site [chemical binding]; other site 1124983003855 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1124983003856 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1124983003857 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1124983003858 adenylate kinase; Reviewed; Region: adk; PRK00279 1124983003859 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1124983003860 AMP-binding site [chemical binding]; other site 1124983003861 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1124983003862 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1124983003863 Glycoprotease family; Region: Peptidase_M22; pfam00814 1124983003864 Protein of unknown function DUF72; Region: DUF72; cl00777 1124983003865 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1124983003866 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1124983003867 tetramer interface [polypeptide binding]; other site 1124983003868 active site 1124983003869 Mg2+/Mn2+ binding site [ion binding]; other site 1124983003870 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1124983003871 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1124983003872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983003873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983003874 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1124983003875 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983003876 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983003877 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983003878 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1124983003879 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1124983003880 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1124983003881 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1124983003882 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1124983003883 putative acyl-acceptor binding pocket; other site 1124983003884 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124983003885 DNA-binding site [nucleotide binding]; DNA binding site 1124983003886 RNA-binding motif; other site 1124983003887 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1124983003888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983003889 S-adenosylmethionine binding site [chemical binding]; other site 1124983003890 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1124983003891 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1124983003892 metal binding site [ion binding]; metal-binding site 1124983003893 dimer interface [polypeptide binding]; other site 1124983003894 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1124983003895 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983003896 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 1124983003897 Ligand binding site; other site 1124983003898 DXD motif; other site 1124983003899 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 1124983003900 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1124983003901 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1124983003902 putative ATP binding site [chemical binding]; other site 1124983003903 putative substrate interface [chemical binding]; other site 1124983003904 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1124983003905 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1124983003906 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1124983003907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983003908 catalytic residue [active] 1124983003909 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1124983003910 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1124983003911 putative trimer interface [polypeptide binding]; other site 1124983003912 putative CoA binding site [chemical binding]; other site 1124983003913 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1124983003914 ArsC family; Region: ArsC; pfam03960 1124983003915 putative catalytic residues [active] 1124983003916 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1124983003917 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1124983003918 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983003919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983003920 homodimer interface [polypeptide binding]; other site 1124983003921 catalytic residue [active] 1124983003922 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1124983003923 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1124983003924 metal binding triad; other site 1124983003925 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1124983003926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983003927 Zn2+ binding site [ion binding]; other site 1124983003928 Mg2+ binding site [ion binding]; other site 1124983003929 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1124983003930 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1124983003931 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1124983003932 active site 1124983003933 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1124983003934 rRNA interaction site [nucleotide binding]; other site 1124983003935 S8 interaction site; other site 1124983003936 putative laminin-1 binding site; other site 1124983003937 elongation factor Ts; Provisional; Region: tsf; PRK09377 1124983003938 UBA/TS-N domain; Region: UBA; pfam00627 1124983003939 Elongation factor TS; Region: EF_TS; pfam00889 1124983003940 Elongation factor TS; Region: EF_TS; pfam00889 1124983003941 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1124983003942 putative nucleotide binding site [chemical binding]; other site 1124983003943 uridine monophosphate binding site [chemical binding]; other site 1124983003944 homohexameric interface [polypeptide binding]; other site 1124983003945 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1124983003946 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1124983003947 hinge region; other site 1124983003948 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1124983003949 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1124983003950 catalytic residue [active] 1124983003951 putative FPP diphosphate binding site; other site 1124983003952 putative FPP binding hydrophobic cleft; other site 1124983003953 dimer interface [polypeptide binding]; other site 1124983003954 putative IPP diphosphate binding site; other site 1124983003955 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1124983003956 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1124983003957 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1124983003958 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1124983003959 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1124983003960 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1124983003961 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1124983003962 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1124983003963 active site 1124983003964 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1124983003965 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1124983003966 protein binding site [polypeptide binding]; other site 1124983003967 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1124983003968 putative substrate binding region [chemical binding]; other site 1124983003969 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1124983003970 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124983003971 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124983003972 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124983003973 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124983003974 Surface antigen; Region: Bac_surface_Ag; pfam01103 1124983003975 periplasmic chaperone; Provisional; Region: PRK10780 1124983003976 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1124983003977 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1124983003978 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1124983003979 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1124983003980 trimer interface [polypeptide binding]; other site 1124983003981 active site 1124983003982 UDP-GlcNAc binding site [chemical binding]; other site 1124983003983 lipid binding site [chemical binding]; lipid-binding site 1124983003984 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1124983003985 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1124983003986 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1124983003987 active site 1124983003988 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1124983003989 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1124983003990 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1124983003991 RNA/DNA hybrid binding site [nucleotide binding]; other site 1124983003992 active site 1124983003993 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1124983003994 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1124983003995 putative active site [active] 1124983003996 putative PHP Thumb interface [polypeptide binding]; other site 1124983003997 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1124983003998 generic binding surface II; other site 1124983003999 generic binding surface I; other site 1124983004000 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1124983004001 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1124983004002 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1124983004003 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1124983004004 Ligand Binding Site [chemical binding]; other site 1124983004005 TilS substrate binding domain; Region: TilS; pfam09179 1124983004006 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1124983004007 CTP synthetase; Validated; Region: pyrG; PRK05380 1124983004008 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1124983004009 Catalytic site [active] 1124983004010 active site 1124983004011 UTP binding site [chemical binding]; other site 1124983004012 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1124983004013 active site 1124983004014 putative oxyanion hole; other site 1124983004015 catalytic triad [active] 1124983004016 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1124983004017 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1124983004018 enolase; Provisional; Region: eno; PRK00077 1124983004019 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1124983004020 dimer interface [polypeptide binding]; other site 1124983004021 metal binding site [ion binding]; metal-binding site 1124983004022 substrate binding pocket [chemical binding]; other site 1124983004023 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1124983004024 Septum formation initiator; Region: DivIC; cl17659 1124983004025 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1124983004026 substrate binding site; other site 1124983004027 dimer interface; other site 1124983004028 LysR family transcriptional regulator; Provisional; Region: PRK14997 1124983004029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004030 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 1124983004031 putative effector binding pocket; other site 1124983004032 putative dimerization interface [polypeptide binding]; other site 1124983004033 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1124983004034 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1124983004035 substrate binding site [chemical binding]; other site 1124983004036 catalytic Zn binding site [ion binding]; other site 1124983004037 NAD binding site [chemical binding]; other site 1124983004038 structural Zn binding site [ion binding]; other site 1124983004039 dimer interface [polypeptide binding]; other site 1124983004040 S-formylglutathione hydrolase; Region: PLN02442 1124983004041 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1124983004042 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1124983004043 homotrimer interaction site [polypeptide binding]; other site 1124983004044 zinc binding site [ion binding]; other site 1124983004045 CDP-binding sites; other site 1124983004046 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1124983004047 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1124983004048 Permutation of conserved domain; other site 1124983004049 active site 1124983004050 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1124983004051 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1124983004052 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1124983004053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983004054 S-adenosylmethionine binding site [chemical binding]; other site 1124983004055 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124983004056 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124983004057 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1124983004058 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1124983004059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983004060 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1124983004061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983004062 DNA binding residues [nucleotide binding] 1124983004063 Ferredoxin [Energy production and conversion]; Region: COG1146 1124983004064 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1124983004065 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1124983004066 MutS domain I; Region: MutS_I; pfam01624 1124983004067 MutS domain II; Region: MutS_II; pfam05188 1124983004068 MutS domain III; Region: MutS_III; pfam05192 1124983004069 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1124983004070 Walker A/P-loop; other site 1124983004071 ATP binding site [chemical binding]; other site 1124983004072 Q-loop/lid; other site 1124983004073 ABC transporter signature motif; other site 1124983004074 Walker B; other site 1124983004075 D-loop; other site 1124983004076 H-loop/switch region; other site 1124983004077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983004078 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983004079 non-specific DNA binding site [nucleotide binding]; other site 1124983004080 salt bridge; other site 1124983004081 sequence-specific DNA binding site [nucleotide binding]; other site 1124983004082 Predicted transcriptional regulator [Transcription]; Region: COG2932 1124983004083 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124983004084 Catalytic site [active] 1124983004085 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1124983004086 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1124983004087 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1124983004088 Baseplate J-like protein; Region: Baseplate_J; cl01294 1124983004089 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1124983004090 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1124983004091 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1124983004092 Phage tail tube protein FII; Region: Phage_tube; pfam04985 1124983004093 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1124983004094 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1124983004095 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1124983004096 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1124983004097 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1124983004098 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1124983004099 active site 1124983004100 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 1124983004101 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 1124983004102 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1124983004103 Phage tail tube protein; Region: Tail_tube; pfam10618 1124983004104 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1124983004105 Phage-related protein [Function unknown]; Region: COG5412 1124983004106 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 1124983004107 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 1124983004108 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1124983004109 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1124983004110 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 1124983004111 Phage protein GP46; Region: GP46; pfam07409 1124983004112 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1124983004113 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1124983004114 Phage Tail Collar Domain; Region: Collar; pfam07484 1124983004115 Predicted chitinase [General function prediction only]; Region: COG3179 1124983004116 catalytic residue [active] 1124983004117 Competence-damaged protein; Region: CinA; pfam02464 1124983004118 recombinase A; Provisional; Region: recA; PRK09354 1124983004119 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1124983004120 hexamer interface [polypeptide binding]; other site 1124983004121 Walker A motif; other site 1124983004122 ATP binding site [chemical binding]; other site 1124983004123 Walker B motif; other site 1124983004124 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1124983004125 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1124983004126 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1124983004127 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1124983004128 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983004129 EamA-like transporter family; Region: EamA; pfam00892 1124983004130 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983004131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983004132 active site 1124983004133 phosphorylation site [posttranslational modification] 1124983004134 intermolecular recognition site; other site 1124983004135 dimerization interface [polypeptide binding]; other site 1124983004136 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983004137 DNA binding residues [nucleotide binding] 1124983004138 dimerization interface [polypeptide binding]; other site 1124983004139 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1124983004140 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1124983004141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004142 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1124983004143 putative dimerization interface [polypeptide binding]; other site 1124983004144 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1124983004145 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1124983004146 FAD binding pocket [chemical binding]; other site 1124983004147 FAD binding motif [chemical binding]; other site 1124983004148 phosphate binding motif [ion binding]; other site 1124983004149 beta-alpha-beta structure motif; other site 1124983004150 NAD binding pocket [chemical binding]; other site 1124983004151 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1124983004152 homodimer interaction site [polypeptide binding]; other site 1124983004153 cofactor binding site; other site 1124983004154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983004155 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1124983004156 NAD(P) binding site [chemical binding]; other site 1124983004157 active site 1124983004158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1124983004159 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1124983004160 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1124983004161 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1124983004162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124983004163 RNA binding surface [nucleotide binding]; other site 1124983004164 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 1124983004165 active site 1124983004166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983004167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983004168 Coenzyme A binding pocket [chemical binding]; other site 1124983004169 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1124983004170 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1124983004171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983004172 FeS/SAM binding site; other site 1124983004173 TRAM domain; Region: TRAM; cl01282 1124983004174 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1124983004175 potassium uptake protein; Region: kup; TIGR00794 1124983004176 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1124983004177 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1124983004178 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1124983004179 Predicted integral membrane protein [Function unknown]; Region: COG0392 1124983004180 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1124983004181 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1124983004182 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1124983004183 active site 1124983004184 DNA polymerase IV; Validated; Region: PRK02406 1124983004185 DNA binding site [nucleotide binding] 1124983004186 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1124983004187 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1124983004188 dimer interface [polypeptide binding]; other site 1124983004189 motif 1; other site 1124983004190 active site 1124983004191 motif 2; other site 1124983004192 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1124983004193 putative deacylase active site [active] 1124983004194 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1124983004195 active site 1124983004196 motif 3; other site 1124983004197 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1124983004198 anticodon binding site; other site 1124983004199 muropeptide transporter; Validated; Region: ampG; cl17669 1124983004200 muropeptide transporter; Validated; Region: ampG; cl17669 1124983004201 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1124983004202 DNA binding site [nucleotide binding] 1124983004203 active site 1124983004204 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1124983004205 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124983004206 DNA-binding site [nucleotide binding]; DNA binding site 1124983004207 RNA-binding motif; other site 1124983004208 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1124983004209 trimer interface [polypeptide binding]; other site 1124983004210 active site 1124983004211 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1124983004212 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983004213 Walker A/P-loop; other site 1124983004214 ATP binding site [chemical binding]; other site 1124983004215 Q-loop/lid; other site 1124983004216 ABC transporter signature motif; other site 1124983004217 Walker B; other site 1124983004218 D-loop; other site 1124983004219 H-loop/switch region; other site 1124983004220 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1124983004221 Predicted deacylase [General function prediction only]; Region: COG3608 1124983004222 active site 1124983004223 Zn binding site [ion binding]; other site 1124983004224 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983004225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983004226 dimer interface [polypeptide binding]; other site 1124983004227 conserved gate region; other site 1124983004228 putative PBP binding loops; other site 1124983004229 ABC-ATPase subunit interface; other site 1124983004230 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983004231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983004232 dimer interface [polypeptide binding]; other site 1124983004233 conserved gate region; other site 1124983004234 putative PBP binding loops; other site 1124983004235 ABC-ATPase subunit interface; other site 1124983004236 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1124983004237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983004238 substrate binding pocket [chemical binding]; other site 1124983004239 membrane-bound complex binding site; other site 1124983004240 hinge residues; other site 1124983004241 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1124983004242 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1124983004243 active site 1124983004244 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1124983004245 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1124983004246 C-terminal domain interface [polypeptide binding]; other site 1124983004247 GSH binding site (G-site) [chemical binding]; other site 1124983004248 dimer interface [polypeptide binding]; other site 1124983004249 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1124983004250 N-terminal domain interface [polypeptide binding]; other site 1124983004251 putative dimer interface [polypeptide binding]; other site 1124983004252 active site 1124983004253 Isochorismatase family; Region: Isochorismatase; pfam00857 1124983004254 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1124983004255 catalytic triad [active] 1124983004256 conserved cis-peptide bond; other site 1124983004257 SEC-C motif; Region: SEC-C; pfam02810 1124983004258 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1124983004259 hypothetical protein; Provisional; Region: PRK00183 1124983004260 SEC-C motif; Region: SEC-C; pfam02810 1124983004261 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983004262 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983004263 ligand binding site [chemical binding]; other site 1124983004264 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 1124983004265 Predicted integral membrane protein [Function unknown]; Region: COG5615 1124983004266 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1124983004267 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1124983004268 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1124983004269 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1124983004270 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124983004271 Beta-lactamase; Region: Beta-lactamase; pfam00144 1124983004272 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983004273 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983004274 ligand binding site [chemical binding]; other site 1124983004275 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1124983004276 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1124983004277 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1124983004278 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1124983004279 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1124983004280 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1124983004281 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1124983004282 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983004283 catalytic residue [active] 1124983004284 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1124983004285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983004286 Predicted membrane protein [Function unknown]; Region: COG3650 1124983004287 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1124983004288 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1124983004289 putative NAD(P) binding site [chemical binding]; other site 1124983004290 homodimer interface [polypeptide binding]; other site 1124983004291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983004292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004293 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983004294 putative effector binding pocket; other site 1124983004295 dimerization interface [polypeptide binding]; other site 1124983004296 Predicted membrane protein [Function unknown]; Region: COG2259 1124983004297 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1124983004298 hypothetical protein; Provisional; Region: PRK05409 1124983004299 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1124983004300 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1124983004301 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1124983004302 Walker A/P-loop; other site 1124983004303 ATP binding site [chemical binding]; other site 1124983004304 Q-loop/lid; other site 1124983004305 ABC transporter signature motif; other site 1124983004306 Walker B; other site 1124983004307 D-loop; other site 1124983004308 H-loop/switch region; other site 1124983004309 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1124983004310 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1124983004311 Walker A/P-loop; other site 1124983004312 ATP binding site [chemical binding]; other site 1124983004313 Q-loop/lid; other site 1124983004314 ABC transporter signature motif; other site 1124983004315 Walker B; other site 1124983004316 D-loop; other site 1124983004317 H-loop/switch region; other site 1124983004318 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1124983004319 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1124983004320 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1124983004321 TM-ABC transporter signature motif; other site 1124983004322 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124983004323 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1124983004324 TM-ABC transporter signature motif; other site 1124983004325 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1124983004326 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1124983004327 dimerization interface [polypeptide binding]; other site 1124983004328 ligand binding site [chemical binding]; other site 1124983004329 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1124983004330 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1124983004331 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124983004332 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1124983004333 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1124983004334 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1124983004335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983004336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983004337 metal binding site [ion binding]; metal-binding site 1124983004338 active site 1124983004339 I-site; other site 1124983004340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983004341 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1124983004342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004343 putative substrate translocation pore; other site 1124983004344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983004345 ATP-dependent helicase HepA; Validated; Region: PRK04914 1124983004346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983004347 ATP binding site [chemical binding]; other site 1124983004348 putative Mg++ binding site [ion binding]; other site 1124983004349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983004350 nucleotide binding region [chemical binding]; other site 1124983004351 ATP-binding site [chemical binding]; other site 1124983004352 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983004353 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1124983004354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983004355 catalytic residue [active] 1124983004356 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1124983004357 homotrimer interaction site [polypeptide binding]; other site 1124983004358 putative active site [active] 1124983004359 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983004360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004361 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983004362 dimerization interface [polypeptide binding]; other site 1124983004363 substrate binding pocket [chemical binding]; other site 1124983004364 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1124983004365 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1124983004366 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1124983004367 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124983004368 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124983004369 benzoate transport; Region: 2A0115; TIGR00895 1124983004370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004371 putative substrate translocation pore; other site 1124983004372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004373 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1124983004374 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1124983004375 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1124983004376 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983004377 dimer interface [polypeptide binding]; other site 1124983004378 active site 1124983004379 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1124983004380 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1124983004381 heterodimer interface [polypeptide binding]; other site 1124983004382 multimer interface [polypeptide binding]; other site 1124983004383 active site 1124983004384 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1124983004385 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1124983004386 heterodimer interface [polypeptide binding]; other site 1124983004387 active site 1124983004388 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1124983004389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004390 putative substrate translocation pore; other site 1124983004391 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1124983004392 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1124983004393 tetramer interface [polypeptide binding]; other site 1124983004394 active site 1124983004395 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1124983004396 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1124983004397 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1124983004398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983004399 S-adenosylmethionine binding site [chemical binding]; other site 1124983004400 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1124983004401 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983004402 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983004403 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1124983004404 Protein export membrane protein; Region: SecD_SecF; cl14618 1124983004405 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1124983004406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983004407 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983004408 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1124983004409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983004410 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1124983004411 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983004412 EamA-like transporter family; Region: EamA; pfam00892 1124983004413 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1124983004414 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1124983004415 FMN binding site [chemical binding]; other site 1124983004416 active site 1124983004417 substrate binding site [chemical binding]; other site 1124983004418 catalytic residue [active] 1124983004419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004420 putative substrate translocation pore; other site 1124983004421 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983004422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983004423 dimerization interface [polypeptide binding]; other site 1124983004424 putative DNA binding site [nucleotide binding]; other site 1124983004425 putative Zn2+ binding site [ion binding]; other site 1124983004426 Protein of unknown function, DUF479; Region: DUF479; cl01203 1124983004427 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124983004428 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1124983004429 putative acyl-acceptor binding pocket; other site 1124983004430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1124983004431 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983004432 Beta-lactamase; Region: Beta-lactamase; pfam00144 1124983004433 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124983004434 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1124983004435 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1124983004436 metal binding site [ion binding]; metal-binding site 1124983004437 putative dimer interface [polypeptide binding]; other site 1124983004438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004439 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983004440 putative substrate translocation pore; other site 1124983004441 amidase; Provisional; Region: PRK07486 1124983004442 Amidase; Region: Amidase; cl11426 1124983004443 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1124983004444 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124983004445 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983004446 YceI-like domain; Region: YceI; pfam04264 1124983004447 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1124983004448 PLD-like domain; Region: PLDc_2; pfam13091 1124983004449 putative active site [active] 1124983004450 catalytic site [active] 1124983004451 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1124983004452 PLD-like domain; Region: PLDc_2; pfam13091 1124983004453 putative active site [active] 1124983004454 catalytic site [active] 1124983004455 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1124983004456 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1124983004457 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1124983004458 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1124983004459 Repair protein; Region: Repair_PSII; pfam04536 1124983004460 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1124983004461 Repair protein; Region: Repair_PSII; pfam04536 1124983004462 Repair protein; Region: Repair_PSII; cl01535 1124983004463 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1124983004464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983004465 S-adenosylmethionine binding site [chemical binding]; other site 1124983004466 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1124983004467 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1124983004468 conserved cys residue [active] 1124983004469 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1124983004470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983004471 DNA-binding site [nucleotide binding]; DNA binding site 1124983004472 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124983004473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983004474 DNA-binding site [nucleotide binding]; DNA binding site 1124983004475 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124983004476 hypothetical protein; Provisional; Region: PRK06102 1124983004477 Amidase; Region: Amidase; cl11426 1124983004478 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1124983004479 active site 1124983004480 catalytic site [active] 1124983004481 Zn binding site [ion binding]; other site 1124983004482 tetramer interface [polypeptide binding]; other site 1124983004483 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1124983004484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004485 benzoate transport; Region: 2A0115; TIGR00895 1124983004486 putative substrate translocation pore; other site 1124983004487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1124983004489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983004490 NAD(P) binding site [chemical binding]; other site 1124983004491 active site 1124983004492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983004493 NAD(P) binding site [chemical binding]; other site 1124983004494 active site 1124983004495 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1124983004496 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1124983004497 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1124983004498 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1124983004499 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983004500 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1124983004501 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983004502 N-terminal plug; other site 1124983004503 ligand-binding site [chemical binding]; other site 1124983004504 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983004505 FecR protein; Region: FecR; pfam04773 1124983004506 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983004507 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1124983004508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983004509 DNA binding residues [nucleotide binding] 1124983004510 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 1124983004511 active site residue [active] 1124983004512 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1124983004513 active site residue [active] 1124983004514 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1124983004515 active site residue [active] 1124983004516 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1124983004517 active site residue [active] 1124983004518 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1124983004519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983004520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983004522 dimerization interface [polypeptide binding]; other site 1124983004523 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1124983004524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983004525 dimer interface [polypeptide binding]; other site 1124983004526 conserved gate region; other site 1124983004527 putative PBP binding loops; other site 1124983004528 ABC-ATPase subunit interface; other site 1124983004529 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1124983004530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983004531 Walker A/P-loop; other site 1124983004532 ATP binding site [chemical binding]; other site 1124983004533 Q-loop/lid; other site 1124983004534 ABC transporter signature motif; other site 1124983004535 Walker B; other site 1124983004536 D-loop; other site 1124983004537 H-loop/switch region; other site 1124983004538 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1124983004539 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983004540 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1124983004541 active site 1124983004542 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 1124983004543 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1124983004544 putative ligand binding site [chemical binding]; other site 1124983004545 putative NAD binding site [chemical binding]; other site 1124983004546 catalytic site [active] 1124983004547 hypothetical protein; Provisional; Region: PRK06208 1124983004548 intersubunit interface [polypeptide binding]; other site 1124983004549 active site 1124983004550 Zn2+ binding site [ion binding]; other site 1124983004551 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983004552 substrate binding pocket [chemical binding]; other site 1124983004553 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1124983004554 membrane-bound complex binding site; other site 1124983004555 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1124983004556 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1124983004557 active site 1124983004558 dimer interface [polypeptide binding]; other site 1124983004559 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1124983004560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983004561 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 1124983004562 homotrimer interaction site [polypeptide binding]; other site 1124983004563 putative active site [active] 1124983004564 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1124983004565 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983004566 N-terminal plug; other site 1124983004567 ligand-binding site [chemical binding]; other site 1124983004568 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1124983004569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983004570 membrane-bound complex binding site; other site 1124983004571 hinge residues; other site 1124983004572 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 1124983004573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983004575 putative substrate translocation pore; other site 1124983004576 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1124983004577 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1124983004578 active site 1124983004579 non-prolyl cis peptide bond; other site 1124983004580 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1124983004581 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1124983004582 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1124983004583 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1124983004584 inhibitor site; inhibition site 1124983004585 active site 1124983004586 dimer interface [polypeptide binding]; other site 1124983004587 catalytic residue [active] 1124983004588 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1124983004589 intersubunit interface [polypeptide binding]; other site 1124983004590 active site 1124983004591 Zn2+ binding site [ion binding]; other site 1124983004592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983004593 non-specific DNA binding site [nucleotide binding]; other site 1124983004594 salt bridge; other site 1124983004595 sequence-specific DNA binding site [nucleotide binding]; other site 1124983004596 Cupin domain; Region: Cupin_2; pfam07883 1124983004597 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1124983004598 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1124983004599 dimer interface [polypeptide binding]; other site 1124983004600 active site 1124983004601 metal binding site [ion binding]; metal-binding site 1124983004602 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983004603 PAS domain S-box; Region: sensory_box; TIGR00229 1124983004604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983004605 putative active site [active] 1124983004606 heme pocket [chemical binding]; other site 1124983004607 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1124983004608 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1124983004609 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983004610 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983004611 metal binding site [ion binding]; metal-binding site 1124983004612 active site 1124983004613 I-site; other site 1124983004614 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1124983004615 oxidoreductase; Provisional; Region: PRK06128 1124983004616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983004617 NAD(P) binding site [chemical binding]; other site 1124983004618 active site 1124983004619 Low affinity iron permease; Region: Iron_permease; pfam04120 1124983004620 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1124983004621 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1124983004622 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983004623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983004624 Coenzyme A binding pocket [chemical binding]; other site 1124983004625 PAS fold; Region: PAS_4; pfam08448 1124983004626 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983004627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983004628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1124983004629 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1124983004630 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983004631 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983004632 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1124983004633 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1124983004634 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1124983004635 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1124983004636 inhibitor site; inhibition site 1124983004637 active site 1124983004638 dimer interface [polypeptide binding]; other site 1124983004639 catalytic residue [active] 1124983004640 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1124983004641 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1124983004642 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1124983004643 dimer interface [polypeptide binding]; other site 1124983004644 NADP binding site [chemical binding]; other site 1124983004645 catalytic residues [active] 1124983004646 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1124983004647 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1124983004648 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983004649 N-terminal plug; other site 1124983004650 ligand-binding site [chemical binding]; other site 1124983004651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983004652 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983004653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1124983004654 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1124983004655 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1124983004656 GAF domain; Region: GAF; pfam01590 1124983004657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983004658 metal binding site [ion binding]; metal-binding site 1124983004659 active site 1124983004660 I-site; other site 1124983004661 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983004662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983004663 S-adenosylmethionine binding site [chemical binding]; other site 1124983004664 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1124983004665 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983004666 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1124983004667 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1124983004668 active site 1124983004669 uracil binding [chemical binding]; other site 1124983004670 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1124983004671 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983004672 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983004673 metal binding site [ion binding]; metal-binding site 1124983004674 active site 1124983004675 I-site; other site 1124983004676 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1124983004677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983004678 substrate binding site [chemical binding]; other site 1124983004679 oxyanion hole (OAH) forming residues; other site 1124983004680 trimer interface [polypeptide binding]; other site 1124983004681 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1124983004682 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1124983004683 ligand binding site [chemical binding]; other site 1124983004684 active site 1124983004685 UGI interface [polypeptide binding]; other site 1124983004686 catalytic site [active] 1124983004687 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1124983004688 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1124983004689 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1124983004690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1124983004691 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1124983004692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1124983004693 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983004694 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1124983004695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983004696 active site 1124983004697 phosphorylation site [posttranslational modification] 1124983004698 intermolecular recognition site; other site 1124983004699 dimerization interface [polypeptide binding]; other site 1124983004700 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983004701 DNA binding site [nucleotide binding] 1124983004702 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1124983004703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983004704 HAMP domain; Region: HAMP; pfam00672 1124983004705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983004706 dimer interface [polypeptide binding]; other site 1124983004707 phosphorylation site [posttranslational modification] 1124983004708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983004709 ATP binding site [chemical binding]; other site 1124983004710 Mg2+ binding site [ion binding]; other site 1124983004711 G-X-G motif; other site 1124983004712 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1124983004713 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1124983004714 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1124983004715 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1124983004716 L-aspartate oxidase; Provisional; Region: PRK09077 1124983004717 L-aspartate oxidase; Provisional; Region: PRK06175 1124983004718 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1124983004719 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1124983004720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983004721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983004722 DNA binding residues [nucleotide binding] 1124983004723 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1124983004724 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1124983004725 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1124983004726 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1124983004727 MucB/RseB family; Region: MucB_RseB; pfam03888 1124983004728 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1124983004729 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1124983004730 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1124983004731 protein binding site [polypeptide binding]; other site 1124983004732 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1124983004733 protein binding site [polypeptide binding]; other site 1124983004734 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1124983004735 Peptidase family M48; Region: Peptidase_M48; cl12018 1124983004736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1124983004737 TPR motif; other site 1124983004738 binding surface 1124983004739 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1124983004740 CPxP motif; other site 1124983004741 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1124983004742 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1124983004743 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1124983004744 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1124983004745 catalytic triad [active] 1124983004746 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1124983004747 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1124983004748 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1124983004749 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1124983004750 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1124983004751 dimer interface [polypeptide binding]; other site 1124983004752 active site 1124983004753 catalytic residue [active] 1124983004754 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1124983004755 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1124983004756 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1124983004757 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1124983004758 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1124983004759 ATP binding site [chemical binding]; other site 1124983004760 active site 1124983004761 substrate binding site [chemical binding]; other site 1124983004762 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1124983004763 putative chaperone protein EcpD; Provisional; Region: PRK09926 1124983004764 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124983004765 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124983004766 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1124983004767 PapC N-terminal domain; Region: PapC_N; pfam13954 1124983004768 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124983004769 PapC C-terminal domain; Region: PapC_C; pfam13953 1124983004770 putative chaperone protein EcpD; Provisional; Region: PRK09926 1124983004771 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124983004772 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124983004773 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1124983004774 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1124983004775 Surface antigen; Region: Bac_surface_Ag; pfam01103 1124983004776 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1124983004777 haemagglutination activity domain; Region: Haemagg_act; smart00912 1124983004778 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1124983004779 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1124983004780 haemagglutination activity domain; Region: Haemagg_act; smart00912 1124983004781 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1124983004782 haemagglutination activity domain; Region: Haemagg_act; smart00912 1124983004783 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1124983004784 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1124983004785 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1124983004786 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1124983004787 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124983004788 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124983004789 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124983004790 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124983004791 CoenzymeA binding site [chemical binding]; other site 1124983004792 subunit interaction site [polypeptide binding]; other site 1124983004793 PHB binding site; other site 1124983004794 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 1124983004795 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983004796 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 1124983004797 acyl-activating enzyme (AAE) consensus motif; other site 1124983004798 putative AMP binding site [chemical binding]; other site 1124983004799 putative active site [active] 1124983004800 putative CoA binding site [chemical binding]; other site 1124983004801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004802 D-galactonate transporter; Region: 2A0114; TIGR00893 1124983004803 putative substrate translocation pore; other site 1124983004804 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1124983004805 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1124983004806 FMN binding site [chemical binding]; other site 1124983004807 substrate binding site [chemical binding]; other site 1124983004808 putative catalytic residue [active] 1124983004809 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1124983004810 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1124983004811 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1124983004812 active site 1124983004813 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1124983004814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983004815 active site 1124983004816 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1124983004817 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983004818 dimer interface [polypeptide binding]; other site 1124983004819 active site 1124983004820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983004821 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1124983004822 substrate binding site [chemical binding]; other site 1124983004823 oxyanion hole (OAH) forming residues; other site 1124983004824 trimer interface [polypeptide binding]; other site 1124983004825 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124983004826 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124983004827 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124983004828 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124983004829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983004830 DNA-binding site [nucleotide binding]; DNA binding site 1124983004831 FCD domain; Region: FCD; pfam07729 1124983004832 short chain dehydrogenase; Provisional; Region: PRK12829 1124983004833 classical (c) SDRs; Region: SDR_c; cd05233 1124983004834 NAD(P) binding site [chemical binding]; other site 1124983004835 active site 1124983004836 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1124983004837 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1124983004838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004839 putative substrate translocation pore; other site 1124983004840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983004841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004842 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1124983004843 putative substrate binding pocket [chemical binding]; other site 1124983004844 putative dimerization interface [polypeptide binding]; other site 1124983004845 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1124983004846 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1124983004847 putative substrate binding pocket [chemical binding]; other site 1124983004848 trimer interface [polypeptide binding]; other site 1124983004849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983004850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004851 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1124983004852 substrate binding pocket [chemical binding]; other site 1124983004853 dimerization interface [polypeptide binding]; other site 1124983004854 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1124983004855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004856 cyanate hydratase; Validated; Region: PRK02866 1124983004857 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1124983004858 oligomer interface [polypeptide binding]; other site 1124983004859 active site 1124983004860 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1124983004861 active site clefts [active] 1124983004862 zinc binding site [ion binding]; other site 1124983004863 dimer interface [polypeptide binding]; other site 1124983004864 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1124983004865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004866 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1124983004867 dimerization interface [polypeptide binding]; other site 1124983004868 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983004869 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983004870 substrate binding pocket [chemical binding]; other site 1124983004871 membrane-bound complex binding site; other site 1124983004872 hinge residues; other site 1124983004873 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1124983004874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983004875 S-adenosylmethionine binding site [chemical binding]; other site 1124983004876 ribonuclease D; Region: rnd; TIGR01388 1124983004877 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1124983004878 putative active site [active] 1124983004879 putative substrate binding site [chemical binding]; other site 1124983004880 catalytic site [active] 1124983004881 HRDC domain; Region: HRDC; pfam00570 1124983004882 YcgL domain; Region: YcgL; cl01189 1124983004883 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1124983004884 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1124983004885 NAD binding site [chemical binding]; other site 1124983004886 ligand binding site [chemical binding]; other site 1124983004887 catalytic site [active] 1124983004888 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1124983004889 putative FMN binding site [chemical binding]; other site 1124983004890 hypothetical protein; Provisional; Region: PRK05170 1124983004891 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1124983004892 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1124983004893 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1124983004894 active site 1124983004895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1124983004896 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1124983004897 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124983004898 ligand binding site [chemical binding]; other site 1124983004899 flexible hinge region; other site 1124983004900 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1124983004901 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124983004902 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1124983004903 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1124983004904 putative active site [active] 1124983004905 putative dimer interface [polypeptide binding]; other site 1124983004906 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1124983004907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983004908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983004910 dimerization interface [polypeptide binding]; other site 1124983004911 benzoate transport; Region: 2A0115; TIGR00895 1124983004912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004913 putative substrate translocation pore; other site 1124983004914 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1124983004915 putative active site [active] 1124983004916 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1124983004917 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1124983004918 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1124983004919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1124983004920 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1124983004921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983004922 Walker A motif; other site 1124983004923 ATP binding site [chemical binding]; other site 1124983004924 Walker B motif; other site 1124983004925 arginine finger; other site 1124983004926 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1124983004927 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1124983004928 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1124983004929 dimer interface [polypeptide binding]; other site 1124983004930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983004931 catalytic residue [active] 1124983004932 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1124983004933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983004934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983004936 dimerization interface [polypeptide binding]; other site 1124983004937 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1124983004938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004939 putative substrate translocation pore; other site 1124983004940 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1124983004941 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1124983004942 putative active site pocket [active] 1124983004943 putative metal binding site [ion binding]; other site 1124983004944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1124983004945 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1124983004946 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1124983004947 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1124983004948 dimer interface [polypeptide binding]; other site 1124983004949 NADP binding site [chemical binding]; other site 1124983004950 catalytic residues [active] 1124983004951 EamA-like transporter family; Region: EamA; pfam00892 1124983004952 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124983004953 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1124983004954 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1124983004955 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1124983004956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983004957 ATP binding site [chemical binding]; other site 1124983004958 putative Mg++ binding site [ion binding]; other site 1124983004959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983004960 nucleotide binding region [chemical binding]; other site 1124983004961 ATP-binding site [chemical binding]; other site 1124983004962 Helicase associated domain (HA2); Region: HA2; pfam04408 1124983004963 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1124983004964 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1124983004965 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1124983004966 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1124983004967 dimer interface [polypeptide binding]; other site 1124983004968 active site 1124983004969 CoA binding pocket [chemical binding]; other site 1124983004970 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1124983004971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983004972 Putative zinc-finger; Region: zf-HC2; pfam13490 1124983004973 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1124983004974 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1124983004975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1124983004976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983004977 putative substrate translocation pore; other site 1124983004978 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983004979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983004980 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983004981 putative effector binding pocket; other site 1124983004982 dimerization interface [polypeptide binding]; other site 1124983004983 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1124983004984 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1124983004985 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1124983004986 amphipathic channel; other site 1124983004987 Asn-Pro-Ala signature motifs; other site 1124983004988 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1124983004989 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983004990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983004991 Walker A/P-loop; other site 1124983004992 ATP binding site [chemical binding]; other site 1124983004993 Q-loop/lid; other site 1124983004994 ABC transporter signature motif; other site 1124983004995 Walker B; other site 1124983004996 D-loop; other site 1124983004997 H-loop/switch region; other site 1124983004998 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1124983004999 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1124983005000 substrate binding site [chemical binding]; other site 1124983005001 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983005002 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983005003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983005004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983005005 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1124983005006 dimerization interface [polypeptide binding]; other site 1124983005007 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1124983005008 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983005009 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124983005010 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1124983005011 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124983005012 helicase 45; Provisional; Region: PTZ00424 1124983005013 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124983005014 ATP binding site [chemical binding]; other site 1124983005015 Mg++ binding site [ion binding]; other site 1124983005016 motif III; other site 1124983005017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983005018 nucleotide binding region [chemical binding]; other site 1124983005019 ATP-binding site [chemical binding]; other site 1124983005020 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1124983005021 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1124983005022 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1124983005023 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1124983005024 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1124983005025 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983005026 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983005027 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1124983005028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983005029 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983005030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983005031 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1124983005032 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1124983005033 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1124983005034 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1124983005035 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1124983005036 S1 domain; Region: S1_2; pfam13509 1124983005037 S1 domain; Region: S1_2; pfam13509 1124983005038 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 1124983005039 EamA-like transporter family; Region: EamA; pfam00892 1124983005040 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1124983005041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983005042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983005043 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1124983005044 putative dimerization interface [polypeptide binding]; other site 1124983005045 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1124983005046 Na binding site [ion binding]; other site 1124983005047 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1124983005048 agmatinase; Region: agmatinase; TIGR01230 1124983005049 oligomer interface [polypeptide binding]; other site 1124983005050 putative active site [active] 1124983005051 Mn binding site [ion binding]; other site 1124983005052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983005053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983005054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983005055 dimerization interface [polypeptide binding]; other site 1124983005056 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1124983005057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1124983005058 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1124983005059 yecA family protein; Region: ygfB_yecA; TIGR02292 1124983005060 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1124983005061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983005062 ATP binding site [chemical binding]; other site 1124983005063 putative Mg++ binding site [ion binding]; other site 1124983005064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983005065 nucleotide binding region [chemical binding]; other site 1124983005066 ATP-binding site [chemical binding]; other site 1124983005067 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1124983005068 HRDC domain; Region: HRDC; pfam00570 1124983005069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124983005070 MarR family; Region: MarR_2; pfam12802 1124983005071 hypothetical protein; Provisional; Region: PRK10279 1124983005072 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1124983005073 active site 1124983005074 nucleophile elbow; other site 1124983005075 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124983005076 Surface antigen; Region: Bac_surface_Ag; pfam01103 1124983005077 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1124983005078 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124983005079 EamA-like transporter family; Region: EamA; pfam00892 1124983005080 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983005081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983005082 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1124983005083 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1124983005084 putative active site [active] 1124983005085 putative metal binding site [ion binding]; other site 1124983005086 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 1124983005087 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1124983005088 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983005089 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983005090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983005091 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1124983005092 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1124983005093 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1124983005094 putative FMN binding site [chemical binding]; other site 1124983005095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983005096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1124983005097 dimerization interface [polypeptide binding]; other site 1124983005098 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1124983005099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983005100 ATP binding site [chemical binding]; other site 1124983005101 Mg2+ binding site [ion binding]; other site 1124983005102 G-X-G motif; other site 1124983005103 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 1124983005104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983005105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983005106 active site 1124983005107 phosphorylation site [posttranslational modification] 1124983005108 intermolecular recognition site; other site 1124983005109 dimerization interface [polypeptide binding]; other site 1124983005110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983005111 DNA binding site [nucleotide binding] 1124983005112 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1124983005113 YciI-like protein; Reviewed; Region: PRK11370 1124983005114 intracellular septation protein A; Reviewed; Region: PRK00259 1124983005115 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1124983005116 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1124983005117 active site 1124983005118 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1124983005119 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1124983005120 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1124983005121 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1124983005122 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1124983005123 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1124983005124 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124983005125 RNA binding surface [nucleotide binding]; other site 1124983005126 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1124983005127 probable active site [active] 1124983005128 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1124983005129 aromatic amino acid transporter; Provisional; Region: PRK10238 1124983005130 hypothetical protein; Provisional; Region: PRK09256 1124983005131 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1124983005132 major facilitator superfamily transporter; Provisional; Region: PRK05122 1124983005133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983005134 putative substrate translocation pore; other site 1124983005135 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1124983005136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983005137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983005138 homodimer interface [polypeptide binding]; other site 1124983005139 catalytic residue [active] 1124983005140 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 1124983005141 aromatic arch; other site 1124983005142 DCoH dimer interaction site [polypeptide binding]; other site 1124983005143 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1124983005144 DCoH tetramer interaction site [polypeptide binding]; other site 1124983005145 substrate binding site [chemical binding]; other site 1124983005146 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1124983005147 cofactor binding site; other site 1124983005148 metal binding site [ion binding]; metal-binding site 1124983005149 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1124983005150 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1124983005151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983005152 putative active site [active] 1124983005153 heme pocket [chemical binding]; other site 1124983005154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983005155 Walker A motif; other site 1124983005156 ATP binding site [chemical binding]; other site 1124983005157 Walker B motif; other site 1124983005158 arginine finger; other site 1124983005159 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1124983005160 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124983005161 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1124983005162 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1124983005163 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124983005164 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1124983005165 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1124983005166 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1124983005167 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1124983005168 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1124983005169 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1124983005170 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1124983005171 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1124983005172 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 1124983005173 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124983005174 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1124983005175 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 1124983005176 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1124983005177 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1124983005178 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1124983005179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1124983005180 active site 1124983005181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983005182 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1124983005183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983005184 active site 1124983005185 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1124983005186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983005187 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983005188 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1124983005189 Probable Catalytic site; other site 1124983005190 metal-binding site 1124983005191 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1124983005192 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1124983005193 NAD(P) binding site [chemical binding]; other site 1124983005194 homodimer interface [polypeptide binding]; other site 1124983005195 substrate binding site [chemical binding]; other site 1124983005196 active site 1124983005197 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1124983005198 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1124983005199 inhibitor-cofactor binding pocket; inhibition site 1124983005200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983005201 catalytic residue [active] 1124983005202 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1124983005203 ligand binding site; other site 1124983005204 tetramer interface; other site 1124983005205 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1124983005206 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1124983005207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983005208 pseudaminic acid synthase; Region: PseI; TIGR03586 1124983005209 NeuB family; Region: NeuB; pfam03102 1124983005210 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1124983005211 NeuB binding interface [polypeptide binding]; other site 1124983005212 putative substrate binding site [chemical binding]; other site 1124983005213 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1124983005214 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1124983005215 dimer interface [polypeptide binding]; other site 1124983005216 active site 1124983005217 CoA binding pocket [chemical binding]; other site 1124983005218 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1124983005219 flagellin; Provisional; Region: PRK12802 1124983005220 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1124983005221 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1124983005222 FlaG protein; Region: FlaG; pfam03646 1124983005223 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1124983005224 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1124983005225 flagellar protein FliS; Validated; Region: fliS; PRK05685 1124983005226 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983005227 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1124983005228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983005229 Walker A motif; other site 1124983005230 ATP binding site [chemical binding]; other site 1124983005231 Walker B motif; other site 1124983005232 arginine finger; other site 1124983005233 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983005234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983005235 dimer interface [polypeptide binding]; other site 1124983005236 phosphorylation site [posttranslational modification] 1124983005237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983005238 ATP binding site [chemical binding]; other site 1124983005239 Mg2+ binding site [ion binding]; other site 1124983005240 G-X-G motif; other site 1124983005241 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983005242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983005243 active site 1124983005244 phosphorylation site [posttranslational modification] 1124983005245 intermolecular recognition site; other site 1124983005246 dimerization interface [polypeptide binding]; other site 1124983005247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983005248 Walker A motif; other site 1124983005249 ATP binding site [chemical binding]; other site 1124983005250 Walker B motif; other site 1124983005251 arginine finger; other site 1124983005252 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983005253 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1124983005254 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1124983005255 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1124983005256 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1124983005257 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1124983005258 MgtE intracellular N domain; Region: MgtE_N; cl15244 1124983005259 FliG C-terminal domain; Region: FliG_C; pfam01706 1124983005260 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1124983005261 Flagellar assembly protein FliH; Region: FliH; pfam02108 1124983005262 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 1124983005263 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1124983005264 Walker A motif/ATP binding site; other site 1124983005265 Walker B motif; other site 1124983005266 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1124983005267 Flagellar FliJ protein; Region: FliJ; pfam02050 1124983005268 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1124983005269 anti sigma factor interaction site; other site 1124983005270 regulatory phosphorylation site [posttranslational modification]; other site 1124983005271 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983005272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983005273 active site 1124983005274 phosphorylation site [posttranslational modification] 1124983005275 intermolecular recognition site; other site 1124983005276 dimerization interface [polypeptide binding]; other site 1124983005277 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1124983005278 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1124983005279 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983005280 putative binding surface; other site 1124983005281 active site 1124983005282 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1124983005283 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 1124983005284 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1124983005285 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1124983005286 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1124983005287 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1124983005288 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1124983005289 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1124983005290 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1124983005291 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1124983005292 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1124983005293 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1124983005294 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1124983005295 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1124983005296 inhibitor-cofactor binding pocket; inhibition site 1124983005297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983005298 catalytic residue [active] 1124983005299 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1124983005300 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1124983005301 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1124983005302 dimer interface [polypeptide binding]; other site 1124983005303 active site 1124983005304 CoA binding pocket [chemical binding]; other site 1124983005305 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1124983005306 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1124983005307 putative trimer interface [polypeptide binding]; other site 1124983005308 putative CoA binding site [chemical binding]; other site 1124983005309 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1124983005310 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1124983005311 [2Fe-2S] cluster binding site [ion binding]; other site 1124983005312 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1124983005313 alpha subunit interface [polypeptide binding]; other site 1124983005314 active site 1124983005315 substrate binding site [chemical binding]; other site 1124983005316 Fe binding site [ion binding]; other site 1124983005317 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1124983005318 putative trimer interface [polypeptide binding]; other site 1124983005319 putative CoA binding site [chemical binding]; other site 1124983005320 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 1124983005321 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1124983005322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1124983005323 active site 1124983005324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983005325 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983005326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983005327 active site 1124983005328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983005329 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1124983005330 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1124983005331 FHIPEP family; Region: FHIPEP; pfam00771 1124983005332 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1124983005333 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1124983005334 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1124983005335 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1124983005336 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1124983005337 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1124983005338 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983005339 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1124983005340 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983005341 DNA binding residues [nucleotide binding] 1124983005342 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1124983005343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983005344 active site 1124983005345 phosphorylation site [posttranslational modification] 1124983005346 intermolecular recognition site; other site 1124983005347 dimerization interface [polypeptide binding]; other site 1124983005348 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 1124983005349 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983005350 putative binding surface; other site 1124983005351 active site 1124983005352 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1124983005353 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1124983005354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983005355 ATP binding site [chemical binding]; other site 1124983005356 Mg2+ binding site [ion binding]; other site 1124983005357 G-X-G motif; other site 1124983005358 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1124983005359 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1124983005360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983005361 active site 1124983005362 phosphorylation site [posttranslational modification] 1124983005363 intermolecular recognition site; other site 1124983005364 dimerization interface [polypeptide binding]; other site 1124983005365 CheB methylesterase; Region: CheB_methylest; pfam01339 1124983005366 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1124983005367 flagellar motor protein; Reviewed; Region: motC; PRK09109 1124983005368 flagellar motor protein MotD; Reviewed; Region: PRK09038 1124983005369 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1124983005370 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983005371 ligand binding site [chemical binding]; other site 1124983005372 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1124983005373 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1124983005374 P-loop; other site 1124983005375 Magnesium ion binding site [ion binding]; other site 1124983005376 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1124983005377 Magnesium ion binding site [ion binding]; other site 1124983005378 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1124983005379 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1124983005380 putative CheA interaction surface; other site 1124983005381 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1124983005382 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1124983005383 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1124983005384 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1124983005385 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1124983005386 Walker A/P-loop; other site 1124983005387 ATP binding site [chemical binding]; other site 1124983005388 Q-loop/lid; other site 1124983005389 ABC transporter signature motif; other site 1124983005390 Walker B; other site 1124983005391 D-loop; other site 1124983005392 H-loop/switch region; other site 1124983005393 heme exporter protein CcmB; Region: ccmB; TIGR01190 1124983005394 CcmB protein; Region: CcmB; cl17444 1124983005395 heme exporter protein CcmC; Region: ccmC; TIGR01191 1124983005396 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1124983005397 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1124983005398 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1124983005399 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1124983005400 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1124983005401 catalytic residues [active] 1124983005402 central insert; other site 1124983005403 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1124983005404 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1124983005405 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1124983005406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983005407 binding surface 1124983005408 TPR motif; other site 1124983005409 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124983005410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983005411 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1124983005412 homotrimer interaction site [polypeptide binding]; other site 1124983005413 putative active site [active] 1124983005414 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1124983005415 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1124983005416 Ion transport protein; Region: Ion_trans; pfam00520 1124983005417 Ion channel; Region: Ion_trans_2; pfam07885 1124983005418 Urea transporter; Region: UT; pfam03253 1124983005419 pyruvate kinase; Provisional; Region: PRK06247 1124983005420 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1124983005421 domain interfaces; other site 1124983005422 active site 1124983005423 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1124983005424 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1124983005425 MOFRL family; Region: MOFRL; pfam05161 1124983005426 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1124983005427 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124983005428 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1124983005429 glyoxylate carboligase; Provisional; Region: PRK11269 1124983005430 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124983005431 PYR/PP interface [polypeptide binding]; other site 1124983005432 dimer interface [polypeptide binding]; other site 1124983005433 TPP binding site [chemical binding]; other site 1124983005434 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124983005435 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1124983005436 TPP-binding site [chemical binding]; other site 1124983005437 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1124983005438 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1124983005439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983005440 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1124983005441 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1124983005442 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1124983005443 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124983005444 VacJ like lipoprotein; Region: VacJ; cl01073 1124983005445 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1124983005446 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1124983005447 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1124983005448 Predicted membrane protein [Function unknown]; Region: COG3162 1124983005449 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1124983005450 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1124983005451 Na binding site [ion binding]; other site 1124983005452 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1124983005453 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1124983005454 dimer interface [polypeptide binding]; other site 1124983005455 active site 1124983005456 citrylCoA binding site [chemical binding]; other site 1124983005457 NADH binding [chemical binding]; other site 1124983005458 cationic pore residues; other site 1124983005459 oxalacetate/citrate binding site [chemical binding]; other site 1124983005460 coenzyme A binding site [chemical binding]; other site 1124983005461 catalytic triad [active] 1124983005462 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1124983005463 Iron-sulfur protein interface; other site 1124983005464 proximal quinone binding site [chemical binding]; other site 1124983005465 SdhD (CybS) interface [polypeptide binding]; other site 1124983005466 proximal heme binding site [chemical binding]; other site 1124983005467 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1124983005468 SdhC subunit interface [polypeptide binding]; other site 1124983005469 proximal heme binding site [chemical binding]; other site 1124983005470 cardiolipin binding site; other site 1124983005471 Iron-sulfur protein interface; other site 1124983005472 proximal quinone binding site [chemical binding]; other site 1124983005473 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 1124983005474 L-aspartate oxidase; Provisional; Region: PRK06175 1124983005475 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1124983005476 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1124983005477 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1124983005478 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1124983005479 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1124983005480 TPP-binding site [chemical binding]; other site 1124983005481 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1124983005482 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1124983005483 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124983005484 E3 interaction surface; other site 1124983005485 lipoyl attachment site [posttranslational modification]; other site 1124983005486 e3 binding domain; Region: E3_binding; pfam02817 1124983005487 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1124983005488 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1124983005489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983005490 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124983005491 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1124983005492 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1124983005493 CoA-ligase; Region: Ligase_CoA; pfam00549 1124983005494 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1124983005495 CoA binding domain; Region: CoA_binding; pfam02629 1124983005496 CoA-ligase; Region: Ligase_CoA; pfam00549 1124983005497 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1124983005498 Predicted membrane protein [Function unknown]; Region: COG3821 1124983005499 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1124983005500 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124983005501 CoenzymeA binding site [chemical binding]; other site 1124983005502 subunit interaction site [polypeptide binding]; other site 1124983005503 PHB binding site; other site 1124983005504 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124983005505 CoenzymeA binding site [chemical binding]; other site 1124983005506 subunit interaction site [polypeptide binding]; other site 1124983005507 PHB binding site; other site 1124983005508 heat shock protein 90; Provisional; Region: PRK05218 1124983005509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983005510 ATP binding site [chemical binding]; other site 1124983005511 Mg2+ binding site [ion binding]; other site 1124983005512 G-X-G motif; other site 1124983005513 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1124983005514 Pirin-related protein [General function prediction only]; Region: COG1741 1124983005515 Pirin; Region: Pirin; pfam02678 1124983005516 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1124983005517 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1124983005518 Amidohydrolase; Region: Amidohydro_2; pfam04909 1124983005519 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 1124983005520 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983005521 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1124983005522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983005523 dimerization interface [polypeptide binding]; other site 1124983005524 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983005525 dimer interface [polypeptide binding]; other site 1124983005526 putative CheW interface [polypeptide binding]; other site 1124983005527 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1124983005528 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1124983005529 dimer interface [polypeptide binding]; other site 1124983005530 active site 1124983005531 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1124983005532 active site 1 [active] 1124983005533 dimer interface [polypeptide binding]; other site 1124983005534 active site 2 [active] 1124983005535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983005536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983005537 dimerization interface [polypeptide binding]; other site 1124983005538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983005539 dimer interface [polypeptide binding]; other site 1124983005540 phosphorylation site [posttranslational modification] 1124983005541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983005542 ATP binding site [chemical binding]; other site 1124983005543 Mg2+ binding site [ion binding]; other site 1124983005544 G-X-G motif; other site 1124983005545 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983005546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983005547 active site 1124983005548 phosphorylation site [posttranslational modification] 1124983005549 intermolecular recognition site; other site 1124983005550 dimerization interface [polypeptide binding]; other site 1124983005551 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1124983005552 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124983005553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124983005554 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1124983005555 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1124983005556 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1124983005557 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1124983005558 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124983005559 catalytic core [active] 1124983005560 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1124983005561 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 1124983005562 acyl-activating enzyme (AAE) consensus motif; other site 1124983005563 putative AMP binding site [chemical binding]; other site 1124983005564 putative active site [active] 1124983005565 putative CoA binding site [chemical binding]; other site 1124983005566 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124983005567 CoenzymeA binding site [chemical binding]; other site 1124983005568 subunit interaction site [polypeptide binding]; other site 1124983005569 PHB binding site; other site 1124983005570 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983005571 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1124983005572 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1124983005573 EF-hand domain; Region: EF_hand_4; pfam13405 1124983005574 Ca2+ binding site [ion binding]; other site 1124983005575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983005576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983005577 dimerization interface [polypeptide binding]; other site 1124983005578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983005579 dimer interface [polypeptide binding]; other site 1124983005580 phosphorylation site [posttranslational modification] 1124983005581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983005582 ATP binding site [chemical binding]; other site 1124983005583 Mg2+ binding site [ion binding]; other site 1124983005584 G-X-G motif; other site 1124983005585 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983005586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983005587 active site 1124983005588 phosphorylation site [posttranslational modification] 1124983005589 intermolecular recognition site; other site 1124983005590 dimerization interface [polypeptide binding]; other site 1124983005591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983005592 DNA binding site [nucleotide binding] 1124983005593 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1124983005594 active site 1124983005595 dimer interface [polypeptide binding]; other site 1124983005596 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1124983005597 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1124983005598 NAD(P) binding site [chemical binding]; other site 1124983005599 substrate binding site [chemical binding]; other site 1124983005600 dimer interface [polypeptide binding]; other site 1124983005601 short chain dehydrogenase; Provisional; Region: PRK06172 1124983005602 classical (c) SDRs; Region: SDR_c; cd05233 1124983005603 NAD(P) binding site [chemical binding]; other site 1124983005604 active site 1124983005605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983005606 dimerization interface [polypeptide binding]; other site 1124983005607 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983005608 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983005609 dimer interface [polypeptide binding]; other site 1124983005610 putative CheW interface [polypeptide binding]; other site 1124983005611 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1124983005612 LysE type translocator; Region: LysE; cl00565 1124983005613 alanine-tRNA ligase; Region: PLN02961 1124983005614 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1124983005615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983005616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983005617 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983005618 putative effector binding pocket; other site 1124983005619 dimerization interface [polypeptide binding]; other site 1124983005620 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1124983005621 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1124983005622 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1124983005623 active site 1124983005624 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1124983005625 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1124983005626 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1124983005627 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983005628 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1124983005629 putative C-terminal domain interface [polypeptide binding]; other site 1124983005630 putative GSH binding site (G-site) [chemical binding]; other site 1124983005631 putative dimer interface [polypeptide binding]; other site 1124983005632 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1124983005633 putative N-terminal domain interface [polypeptide binding]; other site 1124983005634 putative dimer interface [polypeptide binding]; other site 1124983005635 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983005636 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1124983005637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983005638 Walker A/P-loop; other site 1124983005639 ATP binding site [chemical binding]; other site 1124983005640 Q-loop/lid; other site 1124983005641 ABC transporter signature motif; other site 1124983005642 Walker B; other site 1124983005643 D-loop; other site 1124983005644 H-loop/switch region; other site 1124983005645 inner membrane transport permease; Provisional; Region: PRK15066 1124983005646 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124983005647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 1124983005648 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1124983005649 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1124983005650 Competence protein; Region: Competence; pfam03772 1124983005651 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1124983005652 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1124983005653 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1124983005654 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1124983005655 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1124983005656 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1124983005657 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1124983005658 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1124983005659 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1124983005660 Ligand binding site; other site 1124983005661 oligomer interface; other site 1124983005662 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1124983005663 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1124983005664 active site 1124983005665 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1124983005666 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983005667 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1124983005668 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1124983005669 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983005670 catalytic loop [active] 1124983005671 iron binding site [ion binding]; other site 1124983005672 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1124983005673 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1124983005674 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1124983005675 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1124983005676 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1124983005677 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1124983005678 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1124983005679 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1124983005680 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1124983005681 Ligand binding site; other site 1124983005682 metal-binding site 1124983005683 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1124983005684 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1124983005685 homodimer interface [polypeptide binding]; other site 1124983005686 oligonucleotide binding site [chemical binding]; other site 1124983005687 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1124983005688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124983005689 RNA binding surface [nucleotide binding]; other site 1124983005690 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1124983005691 active site 1124983005692 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1124983005693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983005694 motif II; other site 1124983005695 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1124983005696 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1124983005697 tandem repeat interface [polypeptide binding]; other site 1124983005698 oligomer interface [polypeptide binding]; other site 1124983005699 active site residues [active] 1124983005700 Maf-like protein; Region: Maf; pfam02545 1124983005701 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1124983005702 active site 1124983005703 dimer interface [polypeptide binding]; other site 1124983005704 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1124983005705 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1124983005706 putative phosphate acyltransferase; Provisional; Region: PRK05331 1124983005707 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1124983005708 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1124983005709 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1124983005710 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1124983005711 NAD(P) binding site [chemical binding]; other site 1124983005712 homotetramer interface [polypeptide binding]; other site 1124983005713 homodimer interface [polypeptide binding]; other site 1124983005714 active site 1124983005715 acyl carrier protein; Provisional; Region: acpP; PRK00982 1124983005716 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1124983005717 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1124983005718 dimer interface [polypeptide binding]; other site 1124983005719 active site 1124983005720 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1124983005721 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1124983005722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983005723 catalytic residue [active] 1124983005724 YceG-like family; Region: YceG; pfam02618 1124983005725 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1124983005726 dimerization interface [polypeptide binding]; other site 1124983005727 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1124983005728 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1124983005729 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1124983005730 active site 1124983005731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983005732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983005733 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1124983005734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983005735 FeS/SAM binding site; other site 1124983005736 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1124983005737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1124983005738 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1124983005739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983005740 DNA-binding site [nucleotide binding]; DNA binding site 1124983005741 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1124983005742 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1124983005743 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1124983005744 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1124983005745 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1124983005746 Na binding site [ion binding]; other site 1124983005747 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1124983005748 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124983005749 ATP binding site [chemical binding]; other site 1124983005750 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1124983005751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983005752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983005753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983005754 Coenzyme A binding pocket [chemical binding]; other site 1124983005755 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1124983005756 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1124983005757 putative NAD(P) binding site [chemical binding]; other site 1124983005758 putative substrate binding site [chemical binding]; other site 1124983005759 catalytic Zn binding site [ion binding]; other site 1124983005760 structural Zn binding site [ion binding]; other site 1124983005761 dimer interface [polypeptide binding]; other site 1124983005762 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1124983005763 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983005764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983005765 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1124983005766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983005767 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1124983005768 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1124983005769 Ligand binding site [chemical binding]; other site 1124983005770 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1124983005771 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1124983005772 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1124983005773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983005774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983005775 substrate binding pocket [chemical binding]; other site 1124983005776 membrane-bound complex binding site; other site 1124983005777 hinge residues; other site 1124983005778 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1124983005779 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983005780 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983005781 ligand binding site [chemical binding]; other site 1124983005782 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983005783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983005784 DNA-binding site [nucleotide binding]; DNA binding site 1124983005785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983005786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983005787 homodimer interface [polypeptide binding]; other site 1124983005788 catalytic residue [active] 1124983005789 Flagellin N-methylase; Region: FliB; cl00497 1124983005790 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1124983005791 putative lipid binding site [chemical binding]; other site 1124983005792 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1124983005793 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1124983005794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1124983005795 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1124983005796 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1124983005797 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1124983005798 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1124983005799 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983005800 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983005801 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1124983005802 active site residue [active] 1124983005803 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1124983005804 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983005805 dimer interface [polypeptide binding]; other site 1124983005806 active site 1124983005807 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1124983005808 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983005809 substrate binding site [chemical binding]; other site 1124983005810 oxyanion hole (OAH) forming residues; other site 1124983005811 trimer interface [polypeptide binding]; other site 1124983005812 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124983005813 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124983005814 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1124983005815 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1124983005816 catalytic triad [active] 1124983005817 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1124983005818 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1124983005819 oligomer interface [polypeptide binding]; other site 1124983005820 metal binding site [ion binding]; metal-binding site 1124983005821 metal binding site [ion binding]; metal-binding site 1124983005822 putative Cl binding site [ion binding]; other site 1124983005823 basic sphincter; other site 1124983005824 hydrophobic gate; other site 1124983005825 periplasmic entrance; other site 1124983005826 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1124983005827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1124983005828 putative acyl-acceptor binding pocket; other site 1124983005829 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1124983005830 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983005831 substrate binding site [chemical binding]; other site 1124983005832 oxyanion hole (OAH) forming residues; other site 1124983005833 trimer interface [polypeptide binding]; other site 1124983005834 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1124983005835 hydrolase; Region: PLN02811 1124983005836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983005837 motif II; other site 1124983005838 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1124983005839 classical (c) SDRs; Region: SDR_c; cd05233 1124983005840 NAD(P) binding site [chemical binding]; other site 1124983005841 active site 1124983005842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983005843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983005844 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983005845 putative effector binding pocket; other site 1124983005846 dimerization interface [polypeptide binding]; other site 1124983005847 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1124983005848 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1124983005849 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1124983005850 Na binding site [ion binding]; other site 1124983005851 putative substrate binding site [chemical binding]; other site 1124983005852 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1124983005853 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1124983005854 Active Sites [active] 1124983005855 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 1124983005856 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1124983005857 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1124983005858 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1124983005859 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1124983005860 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1124983005861 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1124983005862 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1124983005863 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1124983005864 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124983005865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983005866 DNA-binding site [nucleotide binding]; DNA binding site 1124983005867 FCD domain; Region: FCD; pfam07729 1124983005868 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1124983005869 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1124983005870 tetramer interface [polypeptide binding]; other site 1124983005871 active site 1124983005872 Mg2+/Mn2+ binding site [ion binding]; other site 1124983005873 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1124983005874 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1124983005875 dimer interface [polypeptide binding]; other site 1124983005876 active site 1124983005877 citrylCoA binding site [chemical binding]; other site 1124983005878 oxalacetate/citrate binding site [chemical binding]; other site 1124983005879 coenzyme A binding site [chemical binding]; other site 1124983005880 catalytic triad [active] 1124983005881 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1124983005882 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1124983005883 substrate binding site [chemical binding]; other site 1124983005884 ligand binding site [chemical binding]; other site 1124983005885 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1124983005886 substrate binding site [chemical binding]; other site 1124983005887 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1124983005888 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1124983005889 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1124983005890 EamA-like transporter family; Region: EamA; pfam00892 1124983005891 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124983005892 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983005893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983005894 DNA-binding site [nucleotide binding]; DNA binding site 1124983005895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983005896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983005897 homodimer interface [polypeptide binding]; other site 1124983005898 catalytic residue [active] 1124983005899 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1124983005900 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1124983005901 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1124983005902 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1124983005903 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1124983005904 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983005905 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1124983005906 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1124983005907 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1124983005908 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1124983005909 Cl binding site [ion binding]; other site 1124983005910 oligomer interface [polypeptide binding]; other site 1124983005911 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 1124983005912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983005913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983005914 DNA binding residues [nucleotide binding] 1124983005915 OprF membrane domain; Region: OprF; pfam05736 1124983005916 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983005917 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983005918 ligand binding site [chemical binding]; other site 1124983005919 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1124983005920 active site 1124983005921 SAM binding site [chemical binding]; other site 1124983005922 homodimer interface [polypeptide binding]; other site 1124983005923 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1124983005924 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1124983005925 [4Fe-4S] binding site [ion binding]; other site 1124983005926 molybdopterin cofactor binding site; other site 1124983005927 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1124983005928 molybdopterin cofactor binding site; other site 1124983005929 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1124983005930 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1124983005931 [2Fe-2S] cluster binding site [ion binding]; other site 1124983005932 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1124983005933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983005934 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1124983005935 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1124983005936 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124983005937 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1124983005938 active site 1124983005939 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1124983005940 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1124983005941 active site 1124983005942 ATP binding site [chemical binding]; other site 1124983005943 substrate binding site [chemical binding]; other site 1124983005944 activation loop (A-loop); other site 1124983005945 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1124983005946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983005947 putative substrate translocation pore; other site 1124983005948 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1124983005949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983005950 active site 1124983005951 phosphorylation site [posttranslational modification] 1124983005952 intermolecular recognition site; other site 1124983005953 dimerization interface [polypeptide binding]; other site 1124983005954 ANTAR domain; Region: ANTAR; pfam03861 1124983005955 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1124983005956 NMT1-like family; Region: NMT1_2; pfam13379 1124983005957 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1124983005958 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1124983005959 quinone interaction residues [chemical binding]; other site 1124983005960 active site 1124983005961 catalytic residues [active] 1124983005962 FMN binding site [chemical binding]; other site 1124983005963 substrate binding site [chemical binding]; other site 1124983005964 Ribosome modulation factor; Region: RMF; pfam04957 1124983005965 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1124983005966 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1124983005967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1124983005968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983005969 S-adenosylmethionine binding site [chemical binding]; other site 1124983005970 CHASE domain; Region: CHASE; pfam03924 1124983005971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983005972 PAS domain; Region: PAS_9; pfam13426 1124983005973 putative active site [active] 1124983005974 heme pocket [chemical binding]; other site 1124983005975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983005976 putative active site [active] 1124983005977 heme pocket [chemical binding]; other site 1124983005978 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983005979 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983005980 metal binding site [ion binding]; metal-binding site 1124983005981 active site 1124983005982 I-site; other site 1124983005983 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1124983005984 hypothetical protein; Provisional; Region: PRK11702 1124983005985 benzoate transporter; Region: benE; TIGR00843 1124983005986 Benzoate membrane transport protein; Region: BenE; pfam03594 1124983005987 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124983005988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983005989 DNA-binding site [nucleotide binding]; DNA binding site 1124983005990 FCD domain; Region: FCD; pfam07729 1124983005991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983005992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983005993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983005994 dimerization interface [polypeptide binding]; other site 1124983005995 guanine deaminase; Provisional; Region: PRK09228 1124983005996 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1124983005997 active site 1124983005998 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1124983005999 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1124983006000 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1124983006001 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1124983006002 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1124983006003 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1124983006004 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1124983006005 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983006006 catalytic loop [active] 1124983006007 iron binding site [ion binding]; other site 1124983006008 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1124983006009 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983006010 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1124983006011 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124983006012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983006013 DNA-binding site [nucleotide binding]; DNA binding site 1124983006014 FCD domain; Region: FCD; cl11656 1124983006015 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1124983006016 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1124983006017 Walker A/P-loop; other site 1124983006018 ATP binding site [chemical binding]; other site 1124983006019 Q-loop/lid; other site 1124983006020 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1124983006021 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1124983006022 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1124983006023 ABC transporter signature motif; other site 1124983006024 Walker B; other site 1124983006025 D-loop; other site 1124983006026 H-loop/switch region; other site 1124983006027 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 1124983006028 FtsZ protein binding site [polypeptide binding]; other site 1124983006029 Ligase N family; Region: LIGANc; smart00532 1124983006030 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1124983006031 nucleotide binding pocket [chemical binding]; other site 1124983006032 K-X-D-G motif; other site 1124983006033 catalytic site [active] 1124983006034 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1124983006035 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1124983006036 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1124983006037 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1124983006038 Dimer interface [polypeptide binding]; other site 1124983006039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1124983006040 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1124983006041 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1124983006042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983006043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983006044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983006045 dimerization interface [polypeptide binding]; other site 1124983006046 EamA-like transporter family; Region: EamA; pfam00892 1124983006047 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124983006048 EamA-like transporter family; Region: EamA; pfam00892 1124983006049 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 1124983006050 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1124983006051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124983006052 putative dimer interface [polypeptide binding]; other site 1124983006053 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983006054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983006055 non-specific DNA binding site [nucleotide binding]; other site 1124983006056 salt bridge; other site 1124983006057 sequence-specific DNA binding site [nucleotide binding]; other site 1124983006058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983006059 PAS fold; Region: PAS_3; pfam08447 1124983006060 putative active site [active] 1124983006061 heme pocket [chemical binding]; other site 1124983006062 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983006063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983006064 dimer interface [polypeptide binding]; other site 1124983006065 putative CheW interface [polypeptide binding]; other site 1124983006066 PAS domain; Region: PAS_9; pfam13426 1124983006067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983006068 putative active site [active] 1124983006069 heme pocket [chemical binding]; other site 1124983006070 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983006071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983006072 metal binding site [ion binding]; metal-binding site 1124983006073 active site 1124983006074 I-site; other site 1124983006075 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983006076 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1124983006077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983006078 Walker A motif; other site 1124983006079 ATP binding site [chemical binding]; other site 1124983006080 Walker B motif; other site 1124983006081 arginine finger; other site 1124983006082 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1124983006083 hypothetical protein; Validated; Region: PRK00153 1124983006084 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1124983006085 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1124983006086 NAD(P) binding site [chemical binding]; other site 1124983006087 substrate binding site [chemical binding]; other site 1124983006088 dimer interface [polypeptide binding]; other site 1124983006089 recombination protein RecR; Reviewed; Region: recR; PRK00076 1124983006090 RecR protein; Region: RecR; pfam02132 1124983006091 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1124983006092 putative active site [active] 1124983006093 putative metal-binding site [ion binding]; other site 1124983006094 tetramer interface [polypeptide binding]; other site 1124983006095 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983006096 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983006097 active site 1124983006098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983006099 active site 1124983006100 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1124983006101 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124983006102 ligand binding site [chemical binding]; other site 1124983006103 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1124983006104 putative switch regulator; other site 1124983006105 non-specific DNA interactions [nucleotide binding]; other site 1124983006106 DNA binding site [nucleotide binding] 1124983006107 sequence specific DNA binding site [nucleotide binding]; other site 1124983006108 putative cAMP binding site [chemical binding]; other site 1124983006109 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1124983006110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983006111 FeS/SAM binding site; other site 1124983006112 HemN C-terminal domain; Region: HemN_C; pfam06969 1124983006113 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1124983006114 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1124983006115 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1124983006116 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1124983006117 metal-binding site [ion binding] 1124983006118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124983006119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983006120 motif II; other site 1124983006121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1124983006122 FixH; Region: FixH; pfam05751 1124983006123 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1124983006124 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1124983006125 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1124983006126 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1124983006127 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983006128 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983006129 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1124983006130 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1124983006131 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1124983006132 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1124983006133 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1124983006134 Low-spin heme binding site [chemical binding]; other site 1124983006135 Putative water exit pathway; other site 1124983006136 Binuclear center (active site) [active] 1124983006137 Putative proton exit pathway; other site 1124983006138 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1124983006139 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983006140 Cytochrome c; Region: Cytochrom_C; cl11414 1124983006141 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1124983006142 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1124983006143 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1124983006144 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1124983006145 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1124983006146 Low-spin heme binding site [chemical binding]; other site 1124983006147 Putative water exit pathway; other site 1124983006148 Binuclear center (active site) [active] 1124983006149 Putative proton exit pathway; other site 1124983006150 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1124983006151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983006152 PAS domain; Region: PAS_9; pfam13426 1124983006153 putative active site [active] 1124983006154 heme pocket [chemical binding]; other site 1124983006155 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983006156 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983006157 dimer interface [polypeptide binding]; other site 1124983006158 putative CheW interface [polypeptide binding]; other site 1124983006159 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1124983006160 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1124983006161 Substrate binding site; other site 1124983006162 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1124983006163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983006164 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1124983006165 putative ADP-binding pocket [chemical binding]; other site 1124983006166 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1124983006167 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983006168 active site 1124983006169 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1124983006170 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1124983006171 NADP binding site [chemical binding]; other site 1124983006172 active site 1124983006173 putative substrate binding site [chemical binding]; other site 1124983006174 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1124983006175 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1124983006176 NADP-binding site; other site 1124983006177 homotetramer interface [polypeptide binding]; other site 1124983006178 substrate binding site [chemical binding]; other site 1124983006179 homodimer interface [polypeptide binding]; other site 1124983006180 active site 1124983006181 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1124983006182 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1124983006183 Walker A/P-loop; other site 1124983006184 ATP binding site [chemical binding]; other site 1124983006185 Q-loop/lid; other site 1124983006186 ABC transporter signature motif; other site 1124983006187 Walker B; other site 1124983006188 D-loop; other site 1124983006189 H-loop/switch region; other site 1124983006190 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1124983006191 putative carbohydrate binding site [chemical binding]; other site 1124983006192 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1124983006193 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1124983006194 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1124983006195 NADP binding site [chemical binding]; other site 1124983006196 active site 1124983006197 putative substrate binding site [chemical binding]; other site 1124983006198 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1124983006199 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1124983006200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983006201 S-adenosylmethionine binding site [chemical binding]; other site 1124983006202 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1124983006203 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1124983006204 Ligand binding site; other site 1124983006205 Putative Catalytic site; other site 1124983006206 DXD motif; other site 1124983006207 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1124983006208 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1124983006209 NAD binding site [chemical binding]; other site 1124983006210 homodimer interface [polypeptide binding]; other site 1124983006211 active site 1124983006212 substrate binding site [chemical binding]; other site 1124983006213 aconitate hydratase; Validated; Region: PRK09277 1124983006214 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1124983006215 substrate binding site [chemical binding]; other site 1124983006216 ligand binding site [chemical binding]; other site 1124983006217 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1124983006218 substrate binding site [chemical binding]; other site 1124983006219 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1124983006220 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1124983006221 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1124983006222 CPxP motif; other site 1124983006223 multidrug efflux protein; Reviewed; Region: PRK01766 1124983006224 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1124983006225 cation binding site [ion binding]; other site 1124983006226 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1124983006227 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1124983006228 ligand binding site [chemical binding]; other site 1124983006229 NAD binding site [chemical binding]; other site 1124983006230 catalytic site [active] 1124983006231 homodimer interface [polypeptide binding]; other site 1124983006232 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1124983006233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983006234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983006235 Walker A/P-loop; other site 1124983006236 ATP binding site [chemical binding]; other site 1124983006237 Q-loop/lid; other site 1124983006238 ABC transporter signature motif; other site 1124983006239 Walker B; other site 1124983006240 D-loop; other site 1124983006241 H-loop/switch region; other site 1124983006242 lytic murein transglycosylase; Provisional; Region: PRK11619 1124983006243 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124983006244 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124983006245 catalytic residue [active] 1124983006246 ABC transporter ATPase component; Reviewed; Region: PRK11147 1124983006247 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983006248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983006249 ABC transporter; Region: ABC_tran_2; pfam12848 1124983006250 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983006251 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124983006252 Ligand Binding Site [chemical binding]; other site 1124983006253 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1124983006254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983006255 substrate binding site [chemical binding]; other site 1124983006256 oxyanion hole (OAH) forming residues; other site 1124983006257 trimer interface [polypeptide binding]; other site 1124983006258 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124983006259 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124983006260 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1124983006261 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983006262 dimer interface [polypeptide binding]; other site 1124983006263 active site 1124983006264 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1124983006265 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1124983006266 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1124983006267 active site 1124983006268 interdomain interaction site; other site 1124983006269 putative metal-binding site [ion binding]; other site 1124983006270 nucleotide binding site [chemical binding]; other site 1124983006271 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1124983006272 domain I; other site 1124983006273 DNA binding groove [nucleotide binding] 1124983006274 phosphate binding site [ion binding]; other site 1124983006275 domain II; other site 1124983006276 domain III; other site 1124983006277 nucleotide binding site [chemical binding]; other site 1124983006278 catalytic site [active] 1124983006279 domain IV; other site 1124983006280 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1124983006281 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1124983006282 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1124983006283 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1124983006284 LemA family; Region: LemA; cl00742 1124983006285 Cell division inhibitor SulA; Region: SulA; cl01880 1124983006286 LexA repressor; Validated; Region: PRK00215 1124983006287 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1124983006288 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124983006289 Catalytic site [active] 1124983006290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983006291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983006292 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1124983006293 beta-hexosaminidase; Provisional; Region: PRK05337 1124983006294 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1124983006295 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1124983006296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983006297 ATP binding site [chemical binding]; other site 1124983006298 putative Mg++ binding site [ion binding]; other site 1124983006299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983006300 nucleotide binding region [chemical binding]; other site 1124983006301 ATP-binding site [chemical binding]; other site 1124983006302 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1124983006303 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1124983006304 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1124983006305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983006306 ATP binding site [chemical binding]; other site 1124983006307 putative Mg++ binding site [ion binding]; other site 1124983006308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983006309 nucleotide binding region [chemical binding]; other site 1124983006310 ATP-binding site [chemical binding]; other site 1124983006311 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1124983006312 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1124983006313 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1124983006314 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1124983006315 citrate-proton symporter; Provisional; Region: PRK15075 1124983006316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983006317 putative substrate translocation pore; other site 1124983006318 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1124983006319 ApbE family; Region: ApbE; pfam02424 1124983006320 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1124983006321 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983006322 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124983006323 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1124983006324 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1124983006325 active site 1124983006326 catalytic site [active] 1124983006327 PilZ domain; Region: PilZ; pfam07238 1124983006328 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1124983006329 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124983006330 FtsX-like permease family; Region: FtsX; pfam02687 1124983006331 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1124983006332 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124983006333 Walker A/P-loop; other site 1124983006334 ATP binding site [chemical binding]; other site 1124983006335 Q-loop/lid; other site 1124983006336 ABC transporter signature motif; other site 1124983006337 Walker B; other site 1124983006338 D-loop; other site 1124983006339 H-loop/switch region; other site 1124983006340 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1124983006341 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124983006342 FtsX-like permease family; Region: FtsX; pfam02687 1124983006343 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1124983006344 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983006345 dimerization interface [polypeptide binding]; other site 1124983006346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983006347 dimer interface [polypeptide binding]; other site 1124983006348 phosphorylation site [posttranslational modification] 1124983006349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983006350 ATP binding site [chemical binding]; other site 1124983006351 Mg2+ binding site [ion binding]; other site 1124983006352 G-X-G motif; other site 1124983006353 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1124983006354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983006355 active site 1124983006356 phosphorylation site [posttranslational modification] 1124983006357 intermolecular recognition site; other site 1124983006358 dimerization interface [polypeptide binding]; other site 1124983006359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983006360 DNA binding site [nucleotide binding] 1124983006361 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1124983006362 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1124983006363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1124983006364 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1124983006365 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1124983006366 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1124983006367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1124983006368 active site 1124983006369 motif I; other site 1124983006370 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1124983006371 motif II; other site 1124983006372 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 1124983006373 PilZ domain; Region: PilZ; pfam07238 1124983006374 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983006375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983006376 active site 1124983006377 phosphorylation site [posttranslational modification] 1124983006378 intermolecular recognition site; other site 1124983006379 dimerization interface [polypeptide binding]; other site 1124983006380 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1124983006381 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1124983006382 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1124983006383 anti sigma factor interaction site; other site 1124983006384 regulatory phosphorylation site [posttranslational modification]; other site 1124983006385 transaldolase-like protein; Provisional; Region: PTZ00411 1124983006386 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1124983006387 active site 1124983006388 dimer interface [polypeptide binding]; other site 1124983006389 catalytic residue [active] 1124983006390 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1124983006391 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1124983006392 FMN binding site [chemical binding]; other site 1124983006393 active site 1124983006394 catalytic residues [active] 1124983006395 substrate binding site [chemical binding]; other site 1124983006396 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124983006397 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1124983006398 active site 1124983006399 DNA binding site [nucleotide binding] 1124983006400 Int/Topo IB signature motif; other site 1124983006401 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 1124983006402 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1124983006403 active site 1124983006404 metal binding site [ion binding]; metal-binding site 1124983006405 interdomain interaction site; other site 1124983006406 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1124983006407 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1124983006408 tail protein; Provisional; Region: D; PHA02561 1124983006409 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1124983006410 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1124983006411 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1124983006412 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1124983006413 major tail tube protein; Provisional; Region: FII; PHA02600 1124983006414 major tail sheath protein; Provisional; Region: FI; PHA02560 1124983006415 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1124983006416 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1124983006417 baseplate assembly protein; Provisional; Region: J; PHA02568 1124983006418 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1124983006419 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1124983006420 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1124983006421 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1124983006422 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1124983006423 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1124983006424 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1124983006425 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 1124983006426 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1124983006427 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1124983006428 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1124983006429 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1124983006430 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1124983006431 capsid protein; Provisional; Region: N; PHA02538 1124983006432 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1124983006433 terminase ATPase subunit; Provisional; Region: P; PHA02535 1124983006434 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1124983006435 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1124983006436 portal vertex protein; Provisional; Region: Q; PHA02536 1124983006437 Phage portal protein; Region: Phage_portal; pfam04860 1124983006438 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1124983006439 AAA domain; Region: AAA_23; pfam13476 1124983006440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983006441 Walker B; other site 1124983006442 D-loop; other site 1124983006443 H-loop/switch region; other site 1124983006444 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1124983006445 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1124983006446 Probable Catalytic site; other site 1124983006447 metal-binding site 1124983006448 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1124983006449 putative homodimer interface [polypeptide binding]; other site 1124983006450 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1124983006451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983006452 putative homodimer interface [polypeptide binding]; other site 1124983006453 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983006454 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1124983006455 Probable Catalytic site; other site 1124983006456 metal-binding site 1124983006457 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1124983006458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983006459 S-adenosylmethionine binding site [chemical binding]; other site 1124983006460 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1124983006461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983006462 putative homodimer interface [polypeptide binding]; other site 1124983006463 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983006464 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1124983006465 Probable Catalytic site; other site 1124983006466 metal-binding site 1124983006467 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1124983006468 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1124983006469 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1124983006470 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1124983006471 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1124983006472 Walker A/P-loop; other site 1124983006473 ATP binding site [chemical binding]; other site 1124983006474 Q-loop/lid; other site 1124983006475 ABC transporter signature motif; other site 1124983006476 Walker B; other site 1124983006477 D-loop; other site 1124983006478 H-loop/switch region; other site 1124983006479 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1124983006480 putative carbohydrate binding site [chemical binding]; other site 1124983006481 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1124983006482 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1124983006483 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1124983006484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983006485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983006486 dimerization interface [polypeptide binding]; other site 1124983006487 Cache domain; Region: Cache_1; pfam02743 1124983006488 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983006489 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983006490 metal binding site [ion binding]; metal-binding site 1124983006491 active site 1124983006492 I-site; other site 1124983006493 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983006494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983006495 Coenzyme A binding pocket [chemical binding]; other site 1124983006496 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1124983006497 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983006498 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1124983006499 xanthine permease; Region: pbuX; TIGR03173 1124983006500 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124983006501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983006502 putative substrate translocation pore; other site 1124983006503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983006504 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1124983006505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983006506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983006507 homodimer interface [polypeptide binding]; other site 1124983006508 catalytic residue [active] 1124983006509 excinuclease ABC subunit B; Provisional; Region: PRK05298 1124983006510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983006511 ATP binding site [chemical binding]; other site 1124983006512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983006513 nucleotide binding region [chemical binding]; other site 1124983006514 ATP-binding site [chemical binding]; other site 1124983006515 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1124983006516 UvrB/uvrC motif; Region: UVR; pfam02151 1124983006517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983006518 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1124983006519 putative substrate translocation pore; other site 1124983006520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983006521 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1124983006522 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983006523 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983006524 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1124983006525 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1124983006526 active site 1124983006527 HIGH motif; other site 1124983006528 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1124983006529 active site 1124983006530 KMSKS motif; other site 1124983006531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983006532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983006533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983006534 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1124983006535 active site 1124983006536 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1124983006537 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1124983006538 FMN binding site [chemical binding]; other site 1124983006539 active site 1124983006540 catalytic residues [active] 1124983006541 substrate binding site [chemical binding]; other site 1124983006542 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1124983006543 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1124983006544 putative dimer interface [polypeptide binding]; other site 1124983006545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983006546 PAS fold; Region: PAS_3; pfam08447 1124983006547 putative active site [active] 1124983006548 heme pocket [chemical binding]; other site 1124983006549 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1124983006550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983006551 putative active site [active] 1124983006552 heme pocket [chemical binding]; other site 1124983006553 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1124983006554 PAS domain S-box; Region: sensory_box; TIGR00229 1124983006555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983006556 putative active site [active] 1124983006557 heme pocket [chemical binding]; other site 1124983006558 PAS domain S-box; Region: sensory_box; TIGR00229 1124983006559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983006560 putative active site [active] 1124983006561 heme pocket [chemical binding]; other site 1124983006562 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983006563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983006564 metal binding site [ion binding]; metal-binding site 1124983006565 active site 1124983006566 I-site; other site 1124983006567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983006568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983006569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983006570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983006571 dimerization interface [polypeptide binding]; other site 1124983006572 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1124983006573 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1124983006574 substrate binding site [chemical binding]; other site 1124983006575 ligand binding site [chemical binding]; other site 1124983006576 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1124983006577 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1124983006578 substrate binding site [chemical binding]; other site 1124983006579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983006580 S-adenosylmethionine binding site [chemical binding]; other site 1124983006581 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1124983006582 tartrate dehydrogenase; Region: TTC; TIGR02089 1124983006583 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1124983006584 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1124983006585 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1124983006586 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1124983006587 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1124983006588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124983006589 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1124983006590 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1124983006591 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1124983006592 active site 1124983006593 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1124983006594 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1124983006595 dimerization interface 3.5A [polypeptide binding]; other site 1124983006596 active site 1124983006597 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1124983006598 active site 1124983006599 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1124983006600 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1124983006601 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1124983006602 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124983006603 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124983006604 Sporulation related domain; Region: SPOR; pfam05036 1124983006605 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1124983006606 Colicin V production protein; Region: Colicin_V; cl00567 1124983006607 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1124983006608 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1124983006609 active site 1124983006610 tetramer interface [polypeptide binding]; other site 1124983006611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983006612 active site 1124983006613 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1124983006614 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1124983006615 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1124983006616 homodimer interface [polypeptide binding]; other site 1124983006617 substrate-cofactor binding pocket; other site 1124983006618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983006619 catalytic residue [active] 1124983006620 oxidoreductase; Validated; Region: PRK05717 1124983006621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983006622 NAD(P) binding site [chemical binding]; other site 1124983006623 active site 1124983006624 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983006625 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983006626 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1124983006627 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1124983006628 trimer interface [polypeptide binding]; other site 1124983006629 active site 1124983006630 substrate binding site [chemical binding]; other site 1124983006631 CoA binding site [chemical binding]; other site 1124983006632 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1124983006633 putative peptide chain release factor H; Region: release_prfH; TIGR03072 1124983006634 hypothetical protein; Reviewed; Region: PRK09588 1124983006635 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1124983006636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983006637 non-specific DNA binding site [nucleotide binding]; other site 1124983006638 salt bridge; other site 1124983006639 sequence-specific DNA binding site [nucleotide binding]; other site 1124983006640 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1124983006641 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1124983006642 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1124983006643 putative active site [active] 1124983006644 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1124983006645 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1124983006646 Interdomain contacts; other site 1124983006647 Cytokine receptor motif; other site 1124983006648 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1124983006649 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 1124983006650 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1124983006651 dimer interface [polypeptide binding]; other site 1124983006652 ligand binding site [chemical binding]; other site 1124983006653 carbon storage regulator; Provisional; Region: PRK01712 1124983006654 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1124983006655 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 1124983006656 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1124983006657 homodimer interface [polypeptide binding]; other site 1124983006658 active site 1124983006659 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1124983006660 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1124983006661 ligand binding site [chemical binding]; other site 1124983006662 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1124983006663 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1124983006664 Walker A/P-loop; other site 1124983006665 ATP binding site [chemical binding]; other site 1124983006666 Q-loop/lid; other site 1124983006667 ABC transporter signature motif; other site 1124983006668 Walker B; other site 1124983006669 D-loop; other site 1124983006670 H-loop/switch region; other site 1124983006671 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1124983006672 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124983006673 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1124983006674 TM-ABC transporter signature motif; other site 1124983006675 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124983006676 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124983006677 DNA binding site [nucleotide binding] 1124983006678 domain linker motif; other site 1124983006679 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1124983006680 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124983006681 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1124983006682 substrate binding site [chemical binding]; other site 1124983006683 dimer interface [polypeptide binding]; other site 1124983006684 ATP binding site [chemical binding]; other site 1124983006685 D-ribose pyranase; Provisional; Region: PRK11797 1124983006686 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1124983006687 active site 1124983006688 tetramer interface [polypeptide binding]; other site 1124983006689 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1124983006690 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124983006691 DNA-binding site [nucleotide binding]; DNA binding site 1124983006692 RNA-binding motif; other site 1124983006693 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1124983006694 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1124983006695 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1124983006696 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1124983006697 active site 1124983006698 dimer interface [polypeptide binding]; other site 1124983006699 motif 1; other site 1124983006700 motif 2; other site 1124983006701 motif 3; other site 1124983006702 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1124983006703 anticodon binding site; other site 1124983006704 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1124983006705 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1124983006706 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1124983006707 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1124983006708 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1124983006709 23S rRNA binding site [nucleotide binding]; other site 1124983006710 L21 binding site [polypeptide binding]; other site 1124983006711 L13 binding site [polypeptide binding]; other site 1124983006712 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1124983006713 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1124983006714 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1124983006715 dimer interface [polypeptide binding]; other site 1124983006716 motif 1; other site 1124983006717 active site 1124983006718 motif 2; other site 1124983006719 motif 3; other site 1124983006720 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1124983006721 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1124983006722 putative tRNA-binding site [nucleotide binding]; other site 1124983006723 B3/4 domain; Region: B3_4; pfam03483 1124983006724 tRNA synthetase B5 domain; Region: B5; smart00874 1124983006725 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1124983006726 dimer interface [polypeptide binding]; other site 1124983006727 motif 1; other site 1124983006728 motif 3; other site 1124983006729 motif 2; other site 1124983006730 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1124983006731 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124983006732 IHF dimer interface [polypeptide binding]; other site 1124983006733 IHF - DNA interface [nucleotide binding]; other site 1124983006734 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1124983006735 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1124983006736 DNA binding residues [nucleotide binding] 1124983006737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983006738 non-specific DNA binding site [nucleotide binding]; other site 1124983006739 Predicted transcriptional regulator [Transcription]; Region: COG2932 1124983006740 salt bridge; other site 1124983006741 sequence-specific DNA binding site [nucleotide binding]; other site 1124983006742 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124983006743 Catalytic site [active] 1124983006744 D-mannose binding lectin; Region: B_lectin; pfam01453 1124983006745 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1124983006746 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1124983006747 dimerization interface [polypeptide binding]; other site 1124983006748 mannose binding site [chemical binding]; other site 1124983006749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983006750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983006751 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124983006752 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1124983006753 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1124983006754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983006755 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1124983006756 dimerization interface [polypeptide binding]; other site 1124983006757 substrate binding pocket [chemical binding]; other site 1124983006758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983006759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983006760 putative substrate translocation pore; other site 1124983006761 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1124983006762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983006763 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1124983006764 dimerization interface [polypeptide binding]; other site 1124983006765 substrate binding pocket [chemical binding]; other site 1124983006766 aspartate aminotransferase; Provisional; Region: PRK05764 1124983006767 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983006768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983006769 homodimer interface [polypeptide binding]; other site 1124983006770 catalytic residue [active] 1124983006771 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1124983006772 Class II fumarases; Region: Fumarase_classII; cd01362 1124983006773 active site 1124983006774 tetramer interface [polypeptide binding]; other site 1124983006775 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1124983006776 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1124983006777 tetramer interface [polypeptide binding]; other site 1124983006778 active site 1124983006779 Mg2+/Mn2+ binding site [ion binding]; other site 1124983006780 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983006781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983006782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983006783 DNA binding residues [nucleotide binding] 1124983006784 dimerization interface [polypeptide binding]; other site 1124983006785 Condensation domain; Region: Condensation; pfam00668 1124983006786 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983006787 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983006788 acyl-activating enzyme (AAE) consensus motif; other site 1124983006789 AMP binding site [chemical binding]; other site 1124983006790 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006791 Condensation domain; Region: Condensation; pfam00668 1124983006792 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983006793 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983006794 acyl-activating enzyme (AAE) consensus motif; other site 1124983006795 AMP binding site [chemical binding]; other site 1124983006796 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006797 Condensation domain; Region: Condensation; pfam00668 1124983006798 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983006799 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983006800 acyl-activating enzyme (AAE) consensus motif; other site 1124983006801 AMP binding site [chemical binding]; other site 1124983006802 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006803 Condensation domain; Region: Condensation; pfam00668 1124983006804 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1124983006805 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983006806 acyl-activating enzyme (AAE) consensus motif; other site 1124983006807 AMP binding site [chemical binding]; other site 1124983006808 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006809 Condensation domain; Region: Condensation; pfam00668 1124983006810 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983006811 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983006812 acyl-activating enzyme (AAE) consensus motif; other site 1124983006813 AMP binding site [chemical binding]; other site 1124983006814 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006815 Condensation domain; Region: Condensation; pfam00668 1124983006816 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983006817 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983006818 acyl-activating enzyme (AAE) consensus motif; other site 1124983006819 AMP binding site [chemical binding]; other site 1124983006820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006821 Condensation domain; Region: Condensation; pfam00668 1124983006822 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983006823 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983006824 acyl-activating enzyme (AAE) consensus motif; other site 1124983006825 AMP binding site [chemical binding]; other site 1124983006826 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006827 Condensation domain; Region: Condensation; pfam00668 1124983006828 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983006829 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983006830 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983006831 acyl-activating enzyme (AAE) consensus motif; other site 1124983006832 AMP binding site [chemical binding]; other site 1124983006833 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006834 Condensation domain; Region: Condensation; pfam00668 1124983006835 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983006836 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983006837 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983006838 acyl-activating enzyme (AAE) consensus motif; other site 1124983006839 AMP binding site [chemical binding]; other site 1124983006840 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006841 Condensation domain; Region: Condensation; pfam00668 1124983006842 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1124983006843 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983006844 acyl-activating enzyme (AAE) consensus motif; other site 1124983006845 AMP binding site [chemical binding]; other site 1124983006846 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983006847 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1124983006848 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1124983006849 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1124983006850 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983006851 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1124983006852 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124983006853 Walker A/P-loop; other site 1124983006854 ATP binding site [chemical binding]; other site 1124983006855 Q-loop/lid; other site 1124983006856 ABC transporter signature motif; other site 1124983006857 Walker B; other site 1124983006858 D-loop; other site 1124983006859 H-loop/switch region; other site 1124983006860 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124983006861 FtsX-like permease family; Region: FtsX; pfam02687 1124983006862 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983006863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983006864 DNA binding residues [nucleotide binding] 1124983006865 dimerization interface [polypeptide binding]; other site 1124983006866 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1124983006867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983006868 Coenzyme A binding pocket [chemical binding]; other site 1124983006869 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1124983006870 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124983006871 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1124983006872 dimer interface [polypeptide binding]; other site 1124983006873 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 1124983006874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983006875 FeS/SAM binding site; other site 1124983006876 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1124983006877 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 1124983006878 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 1124983006879 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 1124983006880 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 1124983006881 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 1124983006882 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1124983006883 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1124983006884 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1124983006885 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1124983006886 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983006887 active site 1124983006888 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1124983006889 acyl-CoA synthetase; Validated; Region: PRK08162 1124983006890 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1124983006891 acyl-activating enzyme (AAE) consensus motif; other site 1124983006892 putative active site [active] 1124983006893 AMP binding site [chemical binding]; other site 1124983006894 putative CoA binding site [chemical binding]; other site 1124983006895 PAS domain S-box; Region: sensory_box; TIGR00229 1124983006896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983006897 putative active site [active] 1124983006898 heme pocket [chemical binding]; other site 1124983006899 PAS domain; Region: PAS; smart00091 1124983006900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983006901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983006902 dimer interface [polypeptide binding]; other site 1124983006903 phosphorylation site [posttranslational modification] 1124983006904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983006905 ATP binding site [chemical binding]; other site 1124983006906 G-X-G motif; other site 1124983006907 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1124983006908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983006909 active site 1124983006910 phosphorylation site [posttranslational modification] 1124983006911 intermolecular recognition site; other site 1124983006912 dimerization interface [polypeptide binding]; other site 1124983006913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983006914 DNA binding residues [nucleotide binding] 1124983006915 dimerization interface [polypeptide binding]; other site 1124983006916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983006917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983006918 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1124983006919 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124983006920 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124983006921 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983006922 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983006923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983006924 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1124983006925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983006926 Walker A motif; other site 1124983006927 ATP binding site [chemical binding]; other site 1124983006928 Walker B motif; other site 1124983006929 arginine finger; other site 1124983006930 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983006931 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1124983006932 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1124983006933 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1124983006934 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1124983006935 tetramer interface [polypeptide binding]; other site 1124983006936 TPP-binding site [chemical binding]; other site 1124983006937 heterodimer interface [polypeptide binding]; other site 1124983006938 phosphorylation loop region [posttranslational modification] 1124983006939 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1124983006940 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1124983006941 alpha subunit interface [polypeptide binding]; other site 1124983006942 TPP binding site [chemical binding]; other site 1124983006943 heterodimer interface [polypeptide binding]; other site 1124983006944 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1124983006945 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1124983006946 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124983006947 E3 interaction surface; other site 1124983006948 lipoyl attachment site [posttranslational modification]; other site 1124983006949 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983006950 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1124983006951 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1124983006952 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1124983006953 putative NAD(P) binding site [chemical binding]; other site 1124983006954 catalytic Zn binding site [ion binding]; other site 1124983006955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983006956 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983006957 putative substrate translocation pore; other site 1124983006958 hypothetical protein; Provisional; Region: PRK07079 1124983006959 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1124983006960 metal binding site [ion binding]; metal-binding site 1124983006961 putative dimer interface [polypeptide binding]; other site 1124983006962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983006963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983006964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983006965 dimerization interface [polypeptide binding]; other site 1124983006966 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983006967 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1124983006968 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983006969 dimerization interface [polypeptide binding]; other site 1124983006970 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983006971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983006972 dimer interface [polypeptide binding]; other site 1124983006973 putative CheW interface [polypeptide binding]; other site 1124983006974 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1124983006975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124983006976 MarR family; Region: MarR_2; pfam12802 1124983006977 MarR family; Region: MarR_2; cl17246 1124983006978 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1124983006979 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1124983006980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983006981 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1124983006982 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1124983006983 active site 1124983006984 arsenical pump membrane protein; Provisional; Region: PRK15445 1124983006985 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1124983006986 transmembrane helices; other site 1124983006987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983006988 dimerization interface [polypeptide binding]; other site 1124983006989 putative DNA binding site [nucleotide binding]; other site 1124983006990 putative Zn2+ binding site [ion binding]; other site 1124983006991 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1124983006992 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1124983006993 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1124983006994 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983006995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983006996 Coenzyme A binding pocket [chemical binding]; other site 1124983006997 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983006998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983006999 DNA-binding site [nucleotide binding]; DNA binding site 1124983007000 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983007001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983007002 homodimer interface [polypeptide binding]; other site 1124983007003 catalytic residue [active] 1124983007004 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1124983007005 YcfA-like protein; Region: YcfA; pfam07927 1124983007006 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 1124983007007 hypothetical protein; Provisional; Region: PRK07481 1124983007008 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983007009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983007010 catalytic residue [active] 1124983007011 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1124983007012 TPP-binding site [chemical binding]; other site 1124983007013 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1124983007014 classical (c) SDRs; Region: SDR_c; cd05233 1124983007015 NAD(P) binding site [chemical binding]; other site 1124983007016 active site 1124983007017 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1124983007018 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1124983007019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983007020 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1124983007021 O-methyltransferase; Region: Methyltransf_2; pfam00891 1124983007022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983007023 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983007024 putative substrate translocation pore; other site 1124983007025 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1124983007026 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1124983007027 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983007028 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983007029 Walker A/P-loop; other site 1124983007030 ATP binding site [chemical binding]; other site 1124983007031 Q-loop/lid; other site 1124983007032 ABC transporter signature motif; other site 1124983007033 Walker B; other site 1124983007034 D-loop; other site 1124983007035 H-loop/switch region; other site 1124983007036 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983007037 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983007038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983007039 dimer interface [polypeptide binding]; other site 1124983007040 conserved gate region; other site 1124983007041 putative PBP binding loops; other site 1124983007042 ABC-ATPase subunit interface; other site 1124983007043 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983007044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983007045 dimer interface [polypeptide binding]; other site 1124983007046 conserved gate region; other site 1124983007047 putative PBP binding loops; other site 1124983007048 ABC-ATPase subunit interface; other site 1124983007049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983007050 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983007051 substrate binding pocket [chemical binding]; other site 1124983007052 membrane-bound complex binding site; other site 1124983007053 hinge residues; other site 1124983007054 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1124983007055 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124983007056 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124983007057 putative active site [active] 1124983007058 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1124983007059 Gram-negative porin; Region: Porin_4; pfam13609 1124983007060 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1124983007061 FIST N domain; Region: FIST; pfam08495 1124983007062 FIST C domain; Region: FIST_C; pfam10442 1124983007063 PAS fold; Region: PAS_7; pfam12860 1124983007064 PAS fold; Region: PAS_7; pfam12860 1124983007065 PAS fold; Region: PAS_4; pfam08448 1124983007066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983007067 putative active site [active] 1124983007068 heme pocket [chemical binding]; other site 1124983007069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983007070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983007071 dimer interface [polypeptide binding]; other site 1124983007072 phosphorylation site [posttranslational modification] 1124983007073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983007074 ATP binding site [chemical binding]; other site 1124983007075 Mg2+ binding site [ion binding]; other site 1124983007076 G-X-G motif; other site 1124983007077 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983007078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983007079 active site 1124983007080 phosphorylation site [posttranslational modification] 1124983007081 intermolecular recognition site; other site 1124983007082 dimerization interface [polypeptide binding]; other site 1124983007083 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983007084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983007085 active site 1124983007086 phosphorylation site [posttranslational modification] 1124983007087 intermolecular recognition site; other site 1124983007088 dimerization interface [polypeptide binding]; other site 1124983007089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983007090 DNA binding residues [nucleotide binding] 1124983007091 dimerization interface [polypeptide binding]; other site 1124983007092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1124983007093 active site residue [active] 1124983007094 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1124983007095 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124983007096 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1124983007097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983007098 Walker A/P-loop; other site 1124983007099 ATP binding site [chemical binding]; other site 1124983007100 Q-loop/lid; other site 1124983007101 ABC transporter signature motif; other site 1124983007102 Walker B; other site 1124983007103 D-loop; other site 1124983007104 H-loop/switch region; other site 1124983007105 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1124983007106 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1124983007107 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1124983007108 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1124983007109 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1124983007110 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1124983007111 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1124983007112 ligand binding site [chemical binding]; other site 1124983007113 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1124983007114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1124983007115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1124983007116 Histidine kinase; Region: HisKA_3; pfam07730 1124983007117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983007118 ATP binding site [chemical binding]; other site 1124983007119 Mg2+ binding site [ion binding]; other site 1124983007120 G-X-G motif; other site 1124983007121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983007122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983007123 active site 1124983007124 phosphorylation site [posttranslational modification] 1124983007125 intermolecular recognition site; other site 1124983007126 dimerization interface [polypeptide binding]; other site 1124983007127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983007128 DNA binding residues [nucleotide binding] 1124983007129 dimerization interface [polypeptide binding]; other site 1124983007130 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1124983007131 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1124983007132 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1124983007133 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124983007134 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124983007135 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1124983007136 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124983007137 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124983007138 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1124983007139 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1124983007140 dimer interface [polypeptide binding]; other site 1124983007141 Trp docking motif [polypeptide binding]; other site 1124983007142 active site 1124983007143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983007144 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983007145 substrate binding pocket [chemical binding]; other site 1124983007146 membrane-bound complex binding site; other site 1124983007147 hinge residues; other site 1124983007148 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1124983007149 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1124983007150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1124983007151 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1124983007152 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1124983007153 dimer interface [polypeptide binding]; other site 1124983007154 Trp docking motif [polypeptide binding]; other site 1124983007155 active site 1124983007156 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1124983007157 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983007158 NAD(P) binding site [chemical binding]; other site 1124983007159 catalytic residues [active] 1124983007160 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1124983007161 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1124983007162 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1124983007163 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 1124983007164 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1124983007165 putative active site [active] 1124983007166 metal binding site [ion binding]; metal-binding site 1124983007167 PAS domain S-box; Region: sensory_box; TIGR00229 1124983007168 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1124983007169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983007170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983007171 dimer interface [polypeptide binding]; other site 1124983007172 phosphorylation site [posttranslational modification] 1124983007173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983007174 ATP binding site [chemical binding]; other site 1124983007175 Mg2+ binding site [ion binding]; other site 1124983007176 G-X-G motif; other site 1124983007177 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983007178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983007179 active site 1124983007180 phosphorylation site [posttranslational modification] 1124983007181 intermolecular recognition site; other site 1124983007182 dimerization interface [polypeptide binding]; other site 1124983007183 YniB-like protein; Region: YniB; pfam14002 1124983007184 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1124983007185 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124983007186 Walker A/P-loop; other site 1124983007187 ATP binding site [chemical binding]; other site 1124983007188 Q-loop/lid; other site 1124983007189 ABC transporter signature motif; other site 1124983007190 Walker B; other site 1124983007191 D-loop; other site 1124983007192 H-loop/switch region; other site 1124983007193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124983007194 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1124983007195 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1124983007196 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983007197 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1124983007198 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1124983007199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1124983007200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983007201 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1124983007202 MASE2 domain; Region: MASE2; pfam05230 1124983007203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983007204 metal binding site [ion binding]; metal-binding site 1124983007205 active site 1124983007206 I-site; other site 1124983007207 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1124983007208 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1124983007209 intersubunit interface [polypeptide binding]; other site 1124983007210 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1124983007211 dimer interface [polypeptide binding]; other site 1124983007212 [2Fe-2S] cluster binding site [ion binding]; other site 1124983007213 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1124983007214 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983007215 N-terminal plug; other site 1124983007216 ligand-binding site [chemical binding]; other site 1124983007217 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1124983007218 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1124983007219 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1124983007220 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 1124983007221 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1124983007222 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1124983007223 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1124983007224 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124983007225 Isochorismatase family; Region: Isochorismatase; pfam00857 1124983007226 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1124983007227 catalytic triad [active] 1124983007228 conserved cis-peptide bond; other site 1124983007229 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1124983007230 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124983007231 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124983007232 putative active site [active] 1124983007233 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124983007234 catalytic core [active] 1124983007235 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1124983007236 active site 1124983007237 SAM binding site [chemical binding]; other site 1124983007238 homodimer interface [polypeptide binding]; other site 1124983007239 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1124983007240 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1124983007241 conserved cys residue [active] 1124983007242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983007243 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1124983007244 active site residue [active] 1124983007245 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1124983007246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983007247 substrate binding pocket [chemical binding]; other site 1124983007248 membrane-bound complex binding site; other site 1124983007249 hinge residues; other site 1124983007250 Predicted deacylase [General function prediction only]; Region: COG3608 1124983007251 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1124983007252 active site 1124983007253 Zn binding site [ion binding]; other site 1124983007254 Predicted esterase [General function prediction only]; Region: COG0400 1124983007255 putative hydrolase; Provisional; Region: PRK11460 1124983007256 hypothetical protein; Provisional; Region: PRK11615 1124983007257 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1124983007258 GTP cyclohydrolase I; Provisional; Region: PLN03044 1124983007259 homodecamer interface [polypeptide binding]; other site 1124983007260 active site 1124983007261 putative catalytic site residues [active] 1124983007262 zinc binding site [ion binding]; other site 1124983007263 GTP-CH-I/GFRP interaction surface; other site 1124983007264 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1124983007265 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1124983007266 manganese transport protein MntH; Reviewed; Region: PRK00701 1124983007267 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1124983007268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007270 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983007271 putative effector binding pocket; other site 1124983007272 dimerization interface [polypeptide binding]; other site 1124983007273 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1124983007274 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1124983007275 Domain of unknown function (DUF336); Region: DUF336; cl01249 1124983007276 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1124983007277 Cysteine-rich domain; Region: CCG; pfam02754 1124983007278 Cysteine-rich domain; Region: CCG; pfam02754 1124983007279 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1124983007280 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983007281 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1124983007282 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983007283 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1124983007284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983007285 DNA-binding site [nucleotide binding]; DNA binding site 1124983007286 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124983007287 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 1124983007288 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983007289 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983007290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983007291 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1124983007292 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1124983007293 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1124983007294 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1124983007295 Purine nucleoside permease (NUP); Region: NUP; pfam06516 1124983007296 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1124983007297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1124983007298 selenophosphate synthetase; Provisional; Region: PRK00943 1124983007299 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1124983007300 dimerization interface [polypeptide binding]; other site 1124983007301 putative ATP binding site [chemical binding]; other site 1124983007302 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1124983007303 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1124983007304 active site residue [active] 1124983007305 Predicted permease; Region: DUF318; cl17795 1124983007306 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124983007307 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124983007308 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124983007309 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983007310 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983007311 substrate binding pocket [chemical binding]; other site 1124983007312 membrane-bound complex binding site; other site 1124983007313 hinge residues; other site 1124983007314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983007315 dimer interface [polypeptide binding]; other site 1124983007316 conserved gate region; other site 1124983007317 putative PBP binding loops; other site 1124983007318 ABC-ATPase subunit interface; other site 1124983007319 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983007320 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983007321 Walker A/P-loop; other site 1124983007322 ATP binding site [chemical binding]; other site 1124983007323 Q-loop/lid; other site 1124983007324 ABC transporter signature motif; other site 1124983007325 Walker B; other site 1124983007326 D-loop; other site 1124983007327 H-loop/switch region; other site 1124983007328 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983007329 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983007330 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1124983007331 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1124983007332 C-terminal domain interface [polypeptide binding]; other site 1124983007333 GSH binding site (G-site) [chemical binding]; other site 1124983007334 dimer interface [polypeptide binding]; other site 1124983007335 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1124983007336 dimer interface [polypeptide binding]; other site 1124983007337 N-terminal domain interface [polypeptide binding]; other site 1124983007338 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1124983007339 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1124983007340 dimer interface [polypeptide binding]; other site 1124983007341 active site 1124983007342 Schiff base residues; other site 1124983007343 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1124983007344 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983007345 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983007346 DNA binding residues [nucleotide binding] 1124983007347 fec operon regulator FecR; Reviewed; Region: PRK09774 1124983007348 FecR protein; Region: FecR; pfam04773 1124983007349 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983007350 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1124983007351 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983007352 N-terminal plug; other site 1124983007353 ligand-binding site [chemical binding]; other site 1124983007354 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1124983007355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007356 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1124983007357 dimerization interface [polypeptide binding]; other site 1124983007358 substrate binding pocket [chemical binding]; other site 1124983007359 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1124983007360 classical (c) SDRs; Region: SDR_c; cd05233 1124983007361 NAD(P) binding site [chemical binding]; other site 1124983007362 active site 1124983007363 hypothetical protein; Provisional; Region: PRK06184 1124983007364 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1124983007365 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983007366 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1124983007367 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1124983007368 active site 1124983007369 dimer interface [polypeptide binding]; other site 1124983007370 motif 2; other site 1124983007371 motif 3; other site 1124983007372 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1124983007373 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124983007374 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1124983007375 CoenzymeA binding site [chemical binding]; other site 1124983007376 subunit interaction site [polypeptide binding]; other site 1124983007377 PHB binding site; other site 1124983007378 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1124983007379 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1124983007380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983007381 Walker A motif; other site 1124983007382 ATP binding site [chemical binding]; other site 1124983007383 Walker B motif; other site 1124983007384 arginine finger; other site 1124983007385 TROVE domain; Region: TROVE; pfam05731 1124983007386 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1124983007387 hypothetical protein; Reviewed; Region: PRK09588 1124983007388 HEAT repeats; Region: HEAT_2; pfam13646 1124983007389 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1124983007390 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1124983007391 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1124983007392 putative active site [active] 1124983007393 adenylation catalytic residue [active] 1124983007394 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1124983007395 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983007396 C-terminal domain interface [polypeptide binding]; other site 1124983007397 GSH binding site (G-site) [chemical binding]; other site 1124983007398 dimer interface [polypeptide binding]; other site 1124983007399 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1124983007400 N-terminal domain interface [polypeptide binding]; other site 1124983007401 dimer interface [polypeptide binding]; other site 1124983007402 substrate binding pocket (H-site) [chemical binding]; other site 1124983007403 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1124983007404 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 1124983007405 Cache domain; Region: Cache_1; pfam02743 1124983007406 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983007407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983007408 dimer interface [polypeptide binding]; other site 1124983007409 putative CheW interface [polypeptide binding]; other site 1124983007410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007412 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1124983007413 putative substrate binding pocket [chemical binding]; other site 1124983007414 putative dimerization interface [polypeptide binding]; other site 1124983007415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983007416 putative substrate translocation pore; other site 1124983007417 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1124983007418 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1124983007419 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1124983007420 active site 1124983007421 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983007422 substrate binding site [chemical binding]; other site 1124983007423 catalytic residues [active] 1124983007424 dimer interface [polypeptide binding]; other site 1124983007425 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1124983007426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007427 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983007428 dimerization interface [polypeptide binding]; other site 1124983007429 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1124983007430 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983007431 dimer interface [polypeptide binding]; other site 1124983007432 active site 1124983007433 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1124983007434 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1124983007435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007437 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1124983007438 putative dimerization interface [polypeptide binding]; other site 1124983007439 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1124983007440 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1124983007441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983007442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983007443 CHASE3 domain; Region: CHASE3; pfam05227 1124983007444 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983007445 dimerization interface [polypeptide binding]; other site 1124983007446 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983007447 dimer interface [polypeptide binding]; other site 1124983007448 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1124983007449 putative CheW interface [polypeptide binding]; other site 1124983007450 Sulfatase; Region: Sulfatase; pfam00884 1124983007451 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1124983007452 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1124983007453 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1124983007454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007456 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1124983007457 putative dimerization interface [polypeptide binding]; other site 1124983007458 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1124983007459 FOG: CBS domain [General function prediction only]; Region: COG0517 1124983007460 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1124983007461 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983007462 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1124983007463 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983007464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983007465 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124983007466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983007467 dimer interface [polypeptide binding]; other site 1124983007468 conserved gate region; other site 1124983007469 putative PBP binding loops; other site 1124983007470 ABC-ATPase subunit interface; other site 1124983007471 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1124983007472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983007473 dimer interface [polypeptide binding]; other site 1124983007474 conserved gate region; other site 1124983007475 putative PBP binding loops; other site 1124983007476 ABC-ATPase subunit interface; other site 1124983007477 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1124983007478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983007479 Walker A/P-loop; other site 1124983007480 ATP binding site [chemical binding]; other site 1124983007481 Q-loop/lid; other site 1124983007482 ABC transporter signature motif; other site 1124983007483 Walker B; other site 1124983007484 D-loop; other site 1124983007485 H-loop/switch region; other site 1124983007486 TOBE domain; Region: TOBE_2; pfam08402 1124983007487 Peptidase C26; Region: Peptidase_C26; pfam07722 1124983007488 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1124983007489 catalytic triad [active] 1124983007490 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1124983007491 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124983007492 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1124983007493 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1124983007494 NAD(P) binding site [chemical binding]; other site 1124983007495 catalytic residues [active] 1124983007496 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983007497 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983007498 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1124983007499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983007500 non-specific DNA binding site [nucleotide binding]; other site 1124983007501 salt bridge; other site 1124983007502 sequence-specific DNA binding site [nucleotide binding]; other site 1124983007503 Cupin domain; Region: Cupin_2; pfam07883 1124983007504 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1124983007505 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1124983007506 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1124983007507 GIY-YIG motif/motif A; other site 1124983007508 active site 1124983007509 catalytic site [active] 1124983007510 putative DNA binding site [nucleotide binding]; other site 1124983007511 metal binding site [ion binding]; metal-binding site 1124983007512 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1124983007513 AAA domain; Region: AAA_13; pfam13166 1124983007514 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1124983007515 ABC transporter signature motif; other site 1124983007516 Walker B; other site 1124983007517 D-loop; other site 1124983007518 H-loop/switch region; other site 1124983007519 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 1124983007520 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1124983007521 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1124983007522 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1124983007523 structural tetrad; other site 1124983007524 transcriptional regulator BetI; Validated; Region: PRK00767 1124983007525 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1124983007526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1124983007527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983007528 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1124983007529 NAD(P) binding site [chemical binding]; other site 1124983007530 active site 1124983007531 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1124983007532 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1124983007533 DNA binding residues [nucleotide binding] 1124983007534 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983007535 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983007536 Walker A/P-loop; other site 1124983007537 ATP binding site [chemical binding]; other site 1124983007538 Q-loop/lid; other site 1124983007539 ABC transporter signature motif; other site 1124983007540 Walker B; other site 1124983007541 D-loop; other site 1124983007542 H-loop/switch region; other site 1124983007543 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983007544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983007545 dimer interface [polypeptide binding]; other site 1124983007546 conserved gate region; other site 1124983007547 putative PBP binding loops; other site 1124983007548 ABC-ATPase subunit interface; other site 1124983007549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983007550 dimer interface [polypeptide binding]; other site 1124983007551 conserved gate region; other site 1124983007552 putative PBP binding loops; other site 1124983007553 ABC-ATPase subunit interface; other site 1124983007554 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983007555 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983007556 substrate binding pocket [chemical binding]; other site 1124983007557 membrane-bound complex binding site; other site 1124983007558 hinge residues; other site 1124983007559 hypothetical protein; Provisional; Region: PRK06148 1124983007560 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1124983007561 active site 1124983007562 ATP binding site [chemical binding]; other site 1124983007563 substrate binding site [chemical binding]; other site 1124983007564 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124983007565 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983007566 inhibitor-cofactor binding pocket; inhibition site 1124983007567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983007568 catalytic residue [active] 1124983007569 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983007570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1124983007571 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983007572 RNA polymerase sigma factor; Provisional; Region: PRK12528 1124983007573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983007574 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1124983007575 DNA binding residues [nucleotide binding] 1124983007576 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983007577 FecR protein; Region: FecR; pfam04773 1124983007578 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983007579 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1124983007580 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124983007581 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124983007582 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1124983007583 Family of unknown function (DUF633); Region: DUF633; pfam04816 1124983007584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983007587 dimerization interface [polypeptide binding]; other site 1124983007588 Predicted membrane protein [Function unknown]; Region: COG2259 1124983007589 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1124983007590 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1124983007591 putative NAD(P) binding site [chemical binding]; other site 1124983007592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983007593 Coenzyme A binding pocket [chemical binding]; other site 1124983007594 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983007595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983007596 Coenzyme A binding pocket [chemical binding]; other site 1124983007597 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1124983007598 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983007599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983007600 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1124983007601 Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140 1124983007602 putative RNAase interaction site [polypeptide binding]; other site 1124983007603 EcsC protein family; Region: EcsC; pfam12787 1124983007604 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1124983007605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983007606 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1124983007607 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 1124983007608 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1124983007609 nudix motif; other site 1124983007610 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1124983007611 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983007612 N-terminal plug; other site 1124983007613 ligand-binding site [chemical binding]; other site 1124983007614 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983007615 FecR protein; Region: FecR; pfam04773 1124983007616 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1124983007617 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983007618 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983007619 DNA binding residues [nucleotide binding] 1124983007620 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1124983007621 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1124983007622 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1124983007623 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1124983007624 glutathione S-transferase; Provisional; Region: PRK15113 1124983007625 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1124983007626 C-terminal domain interface [polypeptide binding]; other site 1124983007627 GSH binding site (G-site) [chemical binding]; other site 1124983007628 dimer interface [polypeptide binding]; other site 1124983007629 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1124983007630 N-terminal domain interface [polypeptide binding]; other site 1124983007631 putative dimer interface [polypeptide binding]; other site 1124983007632 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983007633 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1124983007634 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1124983007635 THF binding site; other site 1124983007636 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1124983007637 substrate binding site [chemical binding]; other site 1124983007638 THF binding site; other site 1124983007639 zinc-binding site [ion binding]; other site 1124983007640 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983007641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983007642 DNA-binding site [nucleotide binding]; DNA binding site 1124983007643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983007644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983007645 homodimer interface [polypeptide binding]; other site 1124983007646 catalytic residue [active] 1124983007647 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983007648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983007649 dimerization interface [polypeptide binding]; other site 1124983007650 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983007651 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983007652 dimer interface [polypeptide binding]; other site 1124983007653 putative CheW interface [polypeptide binding]; other site 1124983007654 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983007655 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1124983007656 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1124983007657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1124983007658 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1124983007659 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124983007660 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1124983007661 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1124983007662 active site 1124983007663 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1124983007664 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983007665 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1124983007666 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1124983007667 putative NAD(P) binding site [chemical binding]; other site 1124983007668 putative substrate binding site [chemical binding]; other site 1124983007669 catalytic Zn binding site [ion binding]; other site 1124983007670 structural Zn binding site [ion binding]; other site 1124983007671 dimer interface [polypeptide binding]; other site 1124983007672 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1124983007673 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1124983007674 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1124983007675 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1124983007676 conserved cys residue [active] 1124983007677 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983007678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983007679 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1124983007680 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1124983007681 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124983007682 CoenzymeA binding site [chemical binding]; other site 1124983007683 subunit interaction site [polypeptide binding]; other site 1124983007684 PHB binding site; other site 1124983007685 malate:quinone oxidoreductase; Validated; Region: PRK05257 1124983007686 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1124983007687 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983007688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983007689 Coenzyme A binding pocket [chemical binding]; other site 1124983007690 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124983007691 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124983007692 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124983007693 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1124983007694 active site 1124983007695 NTP binding site [chemical binding]; other site 1124983007696 metal binding triad [ion binding]; metal-binding site 1124983007697 antibiotic binding site [chemical binding]; other site 1124983007698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983007699 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983007700 putative substrate translocation pore; other site 1124983007701 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1124983007702 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983007703 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124983007704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983007705 DNA-binding site [nucleotide binding]; DNA binding site 1124983007706 FCD domain; Region: FCD; pfam07729 1124983007707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983007708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983007709 Coenzyme A binding pocket [chemical binding]; other site 1124983007710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983007713 dimerization interface [polypeptide binding]; other site 1124983007714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983007715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983007716 Coenzyme A binding pocket [chemical binding]; other site 1124983007717 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1124983007718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983007719 S-adenosylmethionine binding site [chemical binding]; other site 1124983007720 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983007721 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1124983007722 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983007723 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1124983007724 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1124983007725 NADP binding site [chemical binding]; other site 1124983007726 dimer interface [polypeptide binding]; other site 1124983007727 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1124983007728 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1124983007729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983007730 Coenzyme A binding pocket [chemical binding]; other site 1124983007731 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1124983007732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983007733 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1124983007734 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1124983007735 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1124983007736 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1124983007737 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1124983007738 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1124983007739 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1124983007740 NAD-dependent deacetylase; Provisional; Region: PRK00481 1124983007741 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1124983007742 NAD+ binding site [chemical binding]; other site 1124983007743 substrate binding site [chemical binding]; other site 1124983007744 Zn binding site [ion binding]; other site 1124983007745 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983007746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983007747 active site 1124983007748 phosphorylation site [posttranslational modification] 1124983007749 intermolecular recognition site; other site 1124983007750 dimerization interface [polypeptide binding]; other site 1124983007751 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1124983007752 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1124983007753 tetramer interface [polypeptide binding]; other site 1124983007754 active site 1124983007755 Mg2+/Mn2+ binding site [ion binding]; other site 1124983007756 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1124983007757 PQQ-like domain; Region: PQQ_2; pfam13360 1124983007758 PAS domain; Region: PAS; smart00091 1124983007759 PAS fold; Region: PAS_4; pfam08448 1124983007760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983007761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983007762 metal binding site [ion binding]; metal-binding site 1124983007763 active site 1124983007764 I-site; other site 1124983007765 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983007766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983007767 active site 1124983007768 phosphorylation site [posttranslational modification] 1124983007769 intermolecular recognition site; other site 1124983007770 dimerization interface [polypeptide binding]; other site 1124983007771 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1124983007772 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1124983007773 acetylornithine aminotransferase; Provisional; Region: PRK02627 1124983007774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983007775 inhibitor-cofactor binding pocket; inhibition site 1124983007776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983007777 catalytic residue [active] 1124983007778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983007781 dimerization interface [polypeptide binding]; other site 1124983007782 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1124983007783 dimer interface [polypeptide binding]; other site 1124983007784 ADP-ribose binding site [chemical binding]; other site 1124983007785 active site 1124983007786 nudix motif; other site 1124983007787 metal binding site [ion binding]; metal-binding site 1124983007788 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1124983007789 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1124983007790 active site 1124983007791 (T/H)XGH motif; other site 1124983007792 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1124983007793 catalytic triad [active] 1124983007794 metal binding site [ion binding]; metal-binding site 1124983007795 conserved cis-peptide bond; other site 1124983007796 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1124983007797 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1124983007798 active site 1124983007799 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1124983007800 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1124983007801 homodimer interface [polypeptide binding]; other site 1124983007802 NAD binding pocket [chemical binding]; other site 1124983007803 ATP binding pocket [chemical binding]; other site 1124983007804 Mg binding site [ion binding]; other site 1124983007805 active-site loop [active] 1124983007806 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1124983007807 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 1124983007808 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1124983007809 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983007810 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983007811 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1124983007812 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124983007813 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1124983007814 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007816 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983007817 putative effector binding pocket; other site 1124983007818 dimerization interface [polypeptide binding]; other site 1124983007819 Isochorismatase family; Region: Isochorismatase; pfam00857 1124983007820 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1124983007821 catalytic triad [active] 1124983007822 dimer interface [polypeptide binding]; other site 1124983007823 conserved cis-peptide bond; other site 1124983007824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1124983007825 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1124983007826 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1124983007827 active site 1124983007828 DNA polymerase II; Reviewed; Region: PRK05762 1124983007829 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1124983007830 active site 1124983007831 catalytic site [active] 1124983007832 substrate binding site [chemical binding]; other site 1124983007833 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1124983007834 active site 1124983007835 metal-binding site 1124983007836 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1124983007837 active site 1124983007838 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1124983007839 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1124983007840 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1124983007841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983007842 putative substrate translocation pore; other site 1124983007843 choline dehydrogenase; Validated; Region: PRK02106 1124983007844 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1124983007845 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1124983007846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983007849 dimerization interface [polypeptide binding]; other site 1124983007850 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1124983007851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983007852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983007853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983007854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983007855 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1124983007856 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1124983007857 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1124983007858 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1124983007859 TrkA-N domain; Region: TrkA_N; pfam02254 1124983007860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983007861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007862 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1124983007863 putative dimerization interface [polypeptide binding]; other site 1124983007864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1124983007865 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1124983007866 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124983007867 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1124983007868 Citrate transporter; Region: CitMHS; pfam03600 1124983007869 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983007870 Peptidase family M48; Region: Peptidase_M48; cl12018 1124983007871 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1124983007872 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1124983007873 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1124983007874 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124983007875 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1124983007876 nudix motif; other site 1124983007877 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1124983007878 putative metal binding site [ion binding]; other site 1124983007879 putative homodimer interface [polypeptide binding]; other site 1124983007880 putative homotetramer interface [polypeptide binding]; other site 1124983007881 putative homodimer-homodimer interface [polypeptide binding]; other site 1124983007882 putative allosteric switch controlling residues; other site 1124983007883 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1124983007884 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983007885 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983007886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983007887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983007888 dimerization interface [polypeptide binding]; other site 1124983007889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983007890 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1124983007891 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1124983007892 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1124983007893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983007894 dimerization interface [polypeptide binding]; other site 1124983007895 putative DNA binding site [nucleotide binding]; other site 1124983007896 putative Zn2+ binding site [ion binding]; other site 1124983007897 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1124983007898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983007899 substrate binding pocket [chemical binding]; other site 1124983007900 membrane-bound complex binding site; other site 1124983007901 hinge residues; other site 1124983007902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983007903 substrate binding pocket [chemical binding]; other site 1124983007904 membrane-bound complex binding site; other site 1124983007905 hinge residues; other site 1124983007906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983007907 putative active site [active] 1124983007908 heme pocket [chemical binding]; other site 1124983007909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983007910 dimer interface [polypeptide binding]; other site 1124983007911 phosphorylation site [posttranslational modification] 1124983007912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983007913 ATP binding site [chemical binding]; other site 1124983007914 Mg2+ binding site [ion binding]; other site 1124983007915 G-X-G motif; other site 1124983007916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983007917 active site 1124983007918 phosphorylation site [posttranslational modification] 1124983007919 intermolecular recognition site; other site 1124983007920 dimerization interface [polypeptide binding]; other site 1124983007921 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983007922 putative binding surface; other site 1124983007923 active site 1124983007924 AAA domain; Region: AAA_33; pfam13671 1124983007925 AAA domain; Region: AAA_17; pfam13207 1124983007926 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1124983007927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1124983007928 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1124983007929 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1124983007930 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1124983007931 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1124983007932 Cupin domain; Region: Cupin_2; pfam07883 1124983007933 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983007934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983007935 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983007936 EamA-like transporter family; Region: EamA; pfam00892 1124983007937 EamA-like transporter family; Region: EamA; pfam00892 1124983007938 Predicted membrane protein [Function unknown]; Region: COG3503 1124983007939 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124983007940 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 1124983007941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983007942 FeS/SAM binding site; other site 1124983007943 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 1124983007944 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1124983007945 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1124983007946 homodimer interface [polypeptide binding]; other site 1124983007947 substrate-cofactor binding pocket; other site 1124983007948 catalytic residue [active] 1124983007949 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1124983007950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983007951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983007952 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124983007953 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1124983007954 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124983007955 E3 interaction surface; other site 1124983007956 lipoyl attachment site [posttranslational modification]; other site 1124983007957 e3 binding domain; Region: E3_binding; pfam02817 1124983007958 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1124983007959 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1124983007960 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1124983007961 alpha subunit interface [polypeptide binding]; other site 1124983007962 TPP binding site [chemical binding]; other site 1124983007963 heterodimer interface [polypeptide binding]; other site 1124983007964 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1124983007965 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1124983007966 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1124983007967 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1124983007968 tetramer interface [polypeptide binding]; other site 1124983007969 TPP-binding site [chemical binding]; other site 1124983007970 heterodimer interface [polypeptide binding]; other site 1124983007971 phosphorylation loop region [posttranslational modification] 1124983007972 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983007973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983007974 putative DNA binding site [nucleotide binding]; other site 1124983007975 putative Zn2+ binding site [ion binding]; other site 1124983007976 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983007977 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1124983007978 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1124983007979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983007980 Zn2+ binding site [ion binding]; other site 1124983007981 Mg2+ binding site [ion binding]; other site 1124983007982 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983007983 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1124983007984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983007985 dimerization interface [polypeptide binding]; other site 1124983007986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983007987 dimer interface [polypeptide binding]; other site 1124983007988 putative CheW interface [polypeptide binding]; other site 1124983007989 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1124983007990 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1124983007991 transmembrane helices; other site 1124983007992 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1124983007993 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1124983007994 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1124983007995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983007996 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1124983007997 putative substrate translocation pore; other site 1124983007998 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1124983007999 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983008000 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983008001 CopC domain; Region: CopC; pfam04234 1124983008002 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983008003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983008004 Coenzyme A binding pocket [chemical binding]; other site 1124983008005 ESCO1/2 acetyl-transferase; Region: Acetyltransf_13; pfam13880 1124983008006 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1124983008007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983008008 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1124983008009 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1124983008010 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1124983008011 homodimer interface [polypeptide binding]; other site 1124983008012 active site 1124983008013 FMN binding site [chemical binding]; other site 1124983008014 substrate binding site [chemical binding]; other site 1124983008015 4Fe-4S binding domain; Region: Fer4; cl02805 1124983008016 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1124983008017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983008018 phenylhydantoinase; Validated; Region: PRK08323 1124983008019 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1124983008020 tetramer interface [polypeptide binding]; other site 1124983008021 active site 1124983008022 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1124983008023 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1124983008024 Na binding site [ion binding]; other site 1124983008025 putative substrate binding site [chemical binding]; other site 1124983008026 allantoate amidohydrolase; Reviewed; Region: PRK12893 1124983008027 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1124983008028 active site 1124983008029 metal binding site [ion binding]; metal-binding site 1124983008030 dimer interface [polypeptide binding]; other site 1124983008031 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1124983008032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983008033 substrate binding pocket [chemical binding]; other site 1124983008034 membrane-bound complex binding site; other site 1124983008035 hinge residues; other site 1124983008036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983008037 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983008038 Walker A/P-loop; other site 1124983008039 ATP binding site [chemical binding]; other site 1124983008040 Q-loop/lid; other site 1124983008041 ABC transporter signature motif; other site 1124983008042 Walker B; other site 1124983008043 D-loop; other site 1124983008044 H-loop/switch region; other site 1124983008045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983008046 dimer interface [polypeptide binding]; other site 1124983008047 conserved gate region; other site 1124983008048 ABC-ATPase subunit interface; other site 1124983008049 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1124983008050 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1124983008051 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1124983008052 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1124983008053 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983008054 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983008055 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983008056 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1124983008057 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1124983008058 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1124983008059 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1124983008060 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1124983008061 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1124983008062 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1124983008063 PAS fold; Region: PAS_4; pfam08448 1124983008064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983008065 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1124983008066 Walker A motif; other site 1124983008067 ATP binding site [chemical binding]; other site 1124983008068 Walker B motif; other site 1124983008069 arginine finger; other site 1124983008070 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983008071 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983008072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983008073 Coenzyme A binding pocket [chemical binding]; other site 1124983008074 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1124983008075 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1124983008076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983008077 putative active site [active] 1124983008078 heme pocket [chemical binding]; other site 1124983008079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983008080 putative active site [active] 1124983008081 heme pocket [chemical binding]; other site 1124983008082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983008083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983008084 DNA binding residues [nucleotide binding] 1124983008085 dimerization interface [polypeptide binding]; other site 1124983008086 CsbD-like; Region: CsbD; cl17424 1124983008087 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1124983008088 Predicted membrane protein [Function unknown]; Region: COG2860 1124983008089 UPF0126 domain; Region: UPF0126; pfam03458 1124983008090 UPF0126 domain; Region: UPF0126; pfam03458 1124983008091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983008092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983008093 dimerization interface [polypeptide binding]; other site 1124983008094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983008095 ATP binding site [chemical binding]; other site 1124983008096 Mg2+ binding site [ion binding]; other site 1124983008097 G-X-G motif; other site 1124983008098 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983008099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983008100 active site 1124983008101 phosphorylation site [posttranslational modification] 1124983008102 intermolecular recognition site; other site 1124983008103 dimerization interface [polypeptide binding]; other site 1124983008104 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983008105 DNA binding site [nucleotide binding] 1124983008106 hypothetical protein; Provisional; Region: PRK10040 1124983008107 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 1124983008108 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983008109 catalytic loop [active] 1124983008110 iron binding site [ion binding]; other site 1124983008111 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1124983008112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983008113 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1124983008114 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983008115 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983008116 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983008117 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1124983008118 C-terminal domain interface [polypeptide binding]; other site 1124983008119 GSH binding site (G-site) [chemical binding]; other site 1124983008120 dimer interface [polypeptide binding]; other site 1124983008121 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1124983008122 dimer interface [polypeptide binding]; other site 1124983008123 N-terminal domain interface [polypeptide binding]; other site 1124983008124 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983008125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983008126 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1124983008127 putative substrate translocation pore; other site 1124983008128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983008129 DNA-binding site [nucleotide binding]; DNA binding site 1124983008130 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983008131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983008132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983008133 homodimer interface [polypeptide binding]; other site 1124983008134 catalytic residue [active] 1124983008135 DHH family; Region: DHH; pfam01368 1124983008136 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1124983008137 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124983008138 putative active site [active] 1124983008139 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124983008140 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1124983008141 substrate binding site [chemical binding]; other site 1124983008142 ATP binding site [chemical binding]; other site 1124983008143 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1124983008144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1124983008145 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1124983008146 KduI/IolB family; Region: KduI; pfam04962 1124983008147 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1124983008148 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1124983008149 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124983008150 PYR/PP interface [polypeptide binding]; other site 1124983008151 dimer interface [polypeptide binding]; other site 1124983008152 TPP binding site [chemical binding]; other site 1124983008153 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124983008154 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1124983008155 TPP-binding site; other site 1124983008156 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1124983008157 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124983008158 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1124983008159 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1124983008160 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1124983008161 putative ligand binding site [chemical binding]; other site 1124983008162 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1124983008163 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1124983008164 Walker A/P-loop; other site 1124983008165 ATP binding site [chemical binding]; other site 1124983008166 Q-loop/lid; other site 1124983008167 ABC transporter signature motif; other site 1124983008168 Walker B; other site 1124983008169 D-loop; other site 1124983008170 H-loop/switch region; other site 1124983008171 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1124983008172 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1124983008173 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1124983008174 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1124983008175 TM-ABC transporter signature motif; other site 1124983008176 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1124983008177 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983008178 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983008179 dimer interface [polypeptide binding]; other site 1124983008180 putative CheW interface [polypeptide binding]; other site 1124983008181 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1124983008182 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1124983008183 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1124983008184 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983008185 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983008186 N-terminal plug; other site 1124983008187 ligand-binding site [chemical binding]; other site 1124983008188 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1124983008189 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1124983008190 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1124983008191 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1124983008192 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1124983008193 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1124983008194 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124983008195 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1124983008196 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1124983008197 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1124983008198 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124983008199 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1124983008200 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1124983008201 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1124983008202 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983008203 EamA-like transporter family; Region: EamA; pfam00892 1124983008204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983008205 non-specific DNA binding site [nucleotide binding]; other site 1124983008206 salt bridge; other site 1124983008207 sequence-specific DNA binding site [nucleotide binding]; other site 1124983008208 Cupin domain; Region: Cupin_2; pfam07883 1124983008209 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1124983008210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983008211 active site 1124983008212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983008213 active site 1124983008214 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1124983008215 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1124983008216 active site 1124983008217 non-prolyl cis peptide bond; other site 1124983008218 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1124983008219 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1124983008220 Walker A/P-loop; other site 1124983008221 ATP binding site [chemical binding]; other site 1124983008222 Q-loop/lid; other site 1124983008223 ABC transporter signature motif; other site 1124983008224 Walker B; other site 1124983008225 D-loop; other site 1124983008226 H-loop/switch region; other site 1124983008227 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1124983008228 TM-ABC transporter signature motif; other site 1124983008229 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1124983008230 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1124983008231 TM-ABC transporter signature motif; other site 1124983008232 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1124983008233 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1124983008234 putative ligand binding site [chemical binding]; other site 1124983008235 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1124983008236 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1124983008237 Walker A/P-loop; other site 1124983008238 ATP binding site [chemical binding]; other site 1124983008239 Q-loop/lid; other site 1124983008240 ABC transporter signature motif; other site 1124983008241 Walker B; other site 1124983008242 D-loop; other site 1124983008243 H-loop/switch region; other site 1124983008244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1124983008245 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1124983008246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983008247 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1124983008248 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124983008249 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1124983008250 short chain dehydrogenase; Provisional; Region: PRK07035 1124983008251 classical (c) SDRs; Region: SDR_c; cd05233 1124983008252 NAD(P) binding site [chemical binding]; other site 1124983008253 active site 1124983008254 Phosphotransferase enzyme family; Region: APH; pfam01636 1124983008255 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1124983008256 putative active site [active] 1124983008257 putative substrate binding site [chemical binding]; other site 1124983008258 ATP binding site [chemical binding]; other site 1124983008259 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1124983008260 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1124983008261 putative ligand binding site [chemical binding]; other site 1124983008262 NAD binding site [chemical binding]; other site 1124983008263 catalytic site [active] 1124983008264 Isochorismatase family; Region: Isochorismatase; pfam00857 1124983008265 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1124983008266 catalytic triad [active] 1124983008267 conserved cis-peptide bond; other site 1124983008268 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1124983008269 serine transporter; Region: stp; TIGR00814 1124983008270 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1124983008271 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1124983008272 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124983008273 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1124983008274 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1124983008275 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1124983008276 substrate binding site [chemical binding]; other site 1124983008277 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1124983008278 substrate binding site [chemical binding]; other site 1124983008279 ligand binding site [chemical binding]; other site 1124983008280 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1124983008281 universal stress protein UspE; Provisional; Region: PRK11175 1124983008282 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124983008283 Ligand Binding Site [chemical binding]; other site 1124983008284 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124983008285 Ligand Binding Site [chemical binding]; other site 1124983008286 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1124983008287 active site 1124983008288 dinuclear metal binding site [ion binding]; other site 1124983008289 dimerization interface [polypeptide binding]; other site 1124983008290 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1124983008291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983008292 active site 1124983008293 phosphorylation site [posttranslational modification] 1124983008294 intermolecular recognition site; other site 1124983008295 dimerization interface [polypeptide binding]; other site 1124983008296 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983008297 DNA binding site [nucleotide binding] 1124983008298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1124983008299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983008300 dimer interface [polypeptide binding]; other site 1124983008301 phosphorylation site [posttranslational modification] 1124983008302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983008303 ATP binding site [chemical binding]; other site 1124983008304 Mg2+ binding site [ion binding]; other site 1124983008305 G-X-G motif; other site 1124983008306 MltA-interacting protein MipA; Region: MipA; cl01504 1124983008307 Beta-lactamase; Region: Beta-lactamase; pfam00144 1124983008308 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124983008309 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1124983008310 Predicted membrane protein [Function unknown]; Region: COG1971 1124983008311 Domain of unknown function DUF; Region: DUF204; pfam02659 1124983008312 Domain of unknown function DUF; Region: DUF204; pfam02659 1124983008313 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983008314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983008315 Coenzyme A binding pocket [chemical binding]; other site 1124983008316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983008318 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1124983008319 putative dimerization interface [polypeptide binding]; other site 1124983008320 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1124983008321 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1124983008322 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1124983008323 active site 2 [active] 1124983008324 active site 1 [active] 1124983008325 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983008326 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983008327 active site 1124983008328 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1124983008329 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1124983008330 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1124983008331 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1124983008332 HD domain; Region: HD_4; pfam13328 1124983008333 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1124983008334 active site 1 [active] 1124983008335 dimer interface [polypeptide binding]; other site 1124983008336 hexamer interface [polypeptide binding]; other site 1124983008337 active site 2 [active] 1124983008338 putative amidase; Provisional; Region: PRK06169 1124983008339 Amidase; Region: Amidase; cl11426 1124983008340 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983008341 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124983008342 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983008343 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983008344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983008345 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1124983008346 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1124983008347 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1124983008348 DctM-like transporters; Region: DctM; pfam06808 1124983008349 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1124983008350 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1124983008351 endonuclease III; Region: ENDO3c; smart00478 1124983008352 minor groove reading motif; other site 1124983008353 helix-hairpin-helix signature motif; other site 1124983008354 substrate binding pocket [chemical binding]; other site 1124983008355 active site 1124983008356 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1124983008357 outer membrane receptor FepA; Provisional; Region: PRK13524 1124983008358 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983008359 N-terminal plug; other site 1124983008360 ligand-binding site [chemical binding]; other site 1124983008361 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983008362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983008363 phosphorylation site [posttranslational modification] 1124983008364 dimer interface [polypeptide binding]; other site 1124983008365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983008366 ATP binding site [chemical binding]; other site 1124983008367 Mg2+ binding site [ion binding]; other site 1124983008368 G-X-G motif; other site 1124983008369 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983008370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983008371 active site 1124983008372 phosphorylation site [posttranslational modification] 1124983008373 intermolecular recognition site; other site 1124983008374 dimerization interface [polypeptide binding]; other site 1124983008375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983008376 DNA binding site [nucleotide binding] 1124983008377 YheO-like PAS domain; Region: PAS_6; pfam08348 1124983008378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1124983008379 HTH domain; Region: HTH_22; pfam13309 1124983008380 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1124983008381 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 1124983008382 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1124983008383 dimer interaction site [polypeptide binding]; other site 1124983008384 substrate-binding tunnel; other site 1124983008385 active site 1124983008386 catalytic site [active] 1124983008387 substrate binding site [chemical binding]; other site 1124983008388 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983008389 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983008390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983008391 putative DNA binding site [nucleotide binding]; other site 1124983008392 putative Zn2+ binding site [ion binding]; other site 1124983008393 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983008394 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1124983008395 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1124983008396 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983008397 Inclusion body protein; Region: PixA; pfam12306 1124983008398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1124983008399 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983008400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983008401 non-specific DNA binding site [nucleotide binding]; other site 1124983008402 salt bridge; other site 1124983008403 sequence-specific DNA binding site [nucleotide binding]; other site 1124983008404 HD domain; Region: HD_3; pfam13023 1124983008405 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1124983008406 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1124983008407 dimer interface [polypeptide binding]; other site 1124983008408 active site 1124983008409 heme binding site [chemical binding]; other site 1124983008410 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1124983008411 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1124983008412 active site 1124983008413 catalytic triad [active] 1124983008414 oxyanion hole [active] 1124983008415 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1124983008416 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1124983008417 NACHT domain; Region: NACHT; pfam05729 1124983008418 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1124983008419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983008420 non-specific DNA binding site [nucleotide binding]; other site 1124983008421 salt bridge; other site 1124983008422 sequence-specific DNA binding site [nucleotide binding]; other site 1124983008423 Cupin domain; Region: Cupin_2; pfam07883 1124983008424 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1124983008425 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1124983008426 putative active site [active] 1124983008427 putative FMN binding site [chemical binding]; other site 1124983008428 putative substrate binding site [chemical binding]; other site 1124983008429 putative catalytic residue [active] 1124983008430 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1124983008431 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124983008432 aldolase II superfamily protein; Provisional; Region: PRK07044 1124983008433 intersubunit interface [polypeptide binding]; other site 1124983008434 active site 1124983008435 Zn2+ binding site [ion binding]; other site 1124983008436 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1124983008437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983008438 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1124983008439 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1124983008440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983008441 active site 1124983008442 phosphorylation site [posttranslational modification] 1124983008443 intermolecular recognition site; other site 1124983008444 dimerization interface [polypeptide binding]; other site 1124983008445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983008446 DNA binding site [nucleotide binding] 1124983008447 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1124983008448 HAMP domain; Region: HAMP; pfam00672 1124983008449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983008450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983008451 dimer interface [polypeptide binding]; other site 1124983008452 phosphorylation site [posttranslational modification] 1124983008453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983008454 ATP binding site [chemical binding]; other site 1124983008455 Mg2+ binding site [ion binding]; other site 1124983008456 G-X-G motif; other site 1124983008457 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983008458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983008459 active site 1124983008460 phosphorylation site [posttranslational modification] 1124983008461 intermolecular recognition site; other site 1124983008462 dimerization interface [polypeptide binding]; other site 1124983008463 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1124983008464 S-methylmethionine transporter; Provisional; Region: PRK11387 1124983008465 enoyl-CoA hydratase; Provisional; Region: PRK06688 1124983008466 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983008467 substrate binding site [chemical binding]; other site 1124983008468 oxyanion hole (OAH) forming residues; other site 1124983008469 trimer interface [polypeptide binding]; other site 1124983008470 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983008471 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983008472 active site 1124983008473 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1124983008474 CoA binding domain; Region: CoA_binding_2; pfam13380 1124983008475 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1124983008476 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1124983008477 hypothetical protein; Provisional; Region: PRK07524 1124983008478 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124983008479 PYR/PP interface [polypeptide binding]; other site 1124983008480 dimer interface [polypeptide binding]; other site 1124983008481 TPP binding site [chemical binding]; other site 1124983008482 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124983008483 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1124983008484 TPP-binding site [chemical binding]; other site 1124983008485 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1124983008486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983008487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983008488 homodimer interface [polypeptide binding]; other site 1124983008489 catalytic residue [active] 1124983008490 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1124983008491 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983008492 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1124983008493 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1124983008494 dimerization interface [polypeptide binding]; other site 1124983008495 ligand binding site [chemical binding]; other site 1124983008496 NADP binding site [chemical binding]; other site 1124983008497 catalytic site [active] 1124983008498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983008499 D-galactonate transporter; Region: 2A0114; TIGR00893 1124983008500 putative substrate translocation pore; other site 1124983008501 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1124983008502 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124983008503 substrate binding site [chemical binding]; other site 1124983008504 ATP binding site [chemical binding]; other site 1124983008505 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1124983008506 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124983008507 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124983008508 DNA binding site [nucleotide binding] 1124983008509 domain linker motif; other site 1124983008510 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1124983008511 putative dimerization interface [polypeptide binding]; other site 1124983008512 putative ligand binding site [chemical binding]; other site 1124983008513 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1124983008514 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1124983008515 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1124983008516 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1124983008517 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983008518 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983008519 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983008520 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983008521 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1124983008522 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1124983008523 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1124983008524 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1124983008525 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1124983008526 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1124983008527 Autotransporter beta-domain; Region: Autotransporter; smart00869 1124983008528 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983008529 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1124983008530 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 1124983008531 putative N-terminal domain interface [polypeptide binding]; other site 1124983008532 putative dimer interface [polypeptide binding]; other site 1124983008533 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983008534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983008535 AAA domain; Region: AAA_23; pfam13476 1124983008536 Walker A/P-loop; other site 1124983008537 ATP binding site [chemical binding]; other site 1124983008538 Q-loop/lid; other site 1124983008539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983008540 ABC transporter signature motif; other site 1124983008541 Walker B; other site 1124983008542 D-loop; other site 1124983008543 H-loop/switch region; other site 1124983008544 exonuclease subunit SbcD; Provisional; Region: PRK10966 1124983008545 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1124983008546 active site 1124983008547 metal binding site [ion binding]; metal-binding site 1124983008548 DNA binding site [nucleotide binding] 1124983008549 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1124983008550 Oxygen tolerance; Region: BatD; pfam13584 1124983008551 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983008552 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1124983008553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983008554 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1124983008555 TPR motif; other site 1124983008556 binding surface 1124983008557 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1124983008558 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1124983008559 metal ion-dependent adhesion site (MIDAS); other site 1124983008560 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1124983008561 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1124983008562 Protein of unknown function DUF58; Region: DUF58; pfam01882 1124983008563 MoxR-like ATPases [General function prediction only]; Region: COG0714 1124983008564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983008565 Walker A motif; other site 1124983008566 ATP binding site [chemical binding]; other site 1124983008567 Walker B motif; other site 1124983008568 arginine finger; other site 1124983008569 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1124983008570 META domain; Region: META; pfam03724 1124983008571 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1124983008572 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1124983008573 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1124983008574 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983008575 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1124983008576 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1124983008577 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1124983008578 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983008579 FecR protein; Region: FecR; pfam04773 1124983008580 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1124983008581 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1124983008582 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1124983008583 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1124983008584 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1124983008585 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1124983008586 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1124983008587 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1124983008588 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1124983008589 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1124983008590 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1124983008591 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1124983008592 GspL periplasmic domain; Region: GspL_C; cl14909 1124983008593 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1124983008594 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1124983008595 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1124983008596 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1124983008597 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1124983008598 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1124983008599 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1124983008600 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1124983008601 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1124983008602 Walker A motif; other site 1124983008603 ATP binding site [chemical binding]; other site 1124983008604 Walker B motif; other site 1124983008605 type II secretion system protein F; Region: GspF; TIGR02120 1124983008606 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124983008607 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124983008608 PBP superfamily domain; Region: PBP_like_2; cl17296 1124983008609 PBP superfamily domain; Region: PBP_like_2; cl17296 1124983008610 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1124983008611 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1124983008612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983008613 S-adenosylmethionine binding site [chemical binding]; other site 1124983008614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983008615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983008616 putative substrate translocation pore; other site 1124983008617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983008619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983008620 dimerization interface [polypeptide binding]; other site 1124983008621 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1124983008622 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983008623 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1124983008624 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1124983008625 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 1124983008626 putative N- and C-terminal domain interface [polypeptide binding]; other site 1124983008627 putative active site [active] 1124983008628 MgATP binding site [chemical binding]; other site 1124983008629 catalytic site [active] 1124983008630 metal binding site [ion binding]; metal-binding site 1124983008631 putative carbohydrate binding site [chemical binding]; other site 1124983008632 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1124983008633 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983008634 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124983008635 Beta-lactamase; Region: Beta-lactamase; pfam00144 1124983008636 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124983008637 amidase; Validated; Region: PRK06565 1124983008638 Amidase; Region: Amidase; cl11426 1124983008639 T5orf172 domain; Region: T5orf172; pfam10544 1124983008640 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1124983008641 YcaO domain protein; Region: TIGR03549 1124983008642 OsmC-like protein; Region: OsmC; pfam02566 1124983008643 YcaO-like family; Region: YcaO; pfam02624 1124983008644 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1124983008645 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1124983008646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983008648 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983008649 putative effector binding pocket; other site 1124983008650 dimerization interface [polypeptide binding]; other site 1124983008651 acyl carrier protein; Provisional; Region: PRK07081 1124983008652 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1124983008653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983008654 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1124983008655 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1124983008656 active site 1124983008657 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1124983008658 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1124983008659 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1124983008660 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1124983008661 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1124983008662 active site 1124983008663 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1124983008664 NADP binding site [chemical binding]; other site 1124983008665 active site 1124983008666 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1124983008667 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1124983008668 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1124983008669 active site 1124983008670 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1124983008671 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1124983008672 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1124983008673 KR domain; Region: KR; pfam08659 1124983008674 NADP binding site [chemical binding]; other site 1124983008675 active site 1124983008676 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983008677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983008678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983008679 active site 1124983008680 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1124983008681 AMP-binding enzyme; Region: AMP-binding; pfam00501 1124983008682 acyl-activating enzyme (AAE) consensus motif; other site 1124983008683 AMP binding site [chemical binding]; other site 1124983008684 Thioesterase domain; Region: Thioesterase; pfam00975 1124983008685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983008686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983008687 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1124983008688 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1124983008689 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983008690 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983008691 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1124983008692 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1124983008693 Walker A/P-loop; other site 1124983008694 ATP binding site [chemical binding]; other site 1124983008695 Q-loop/lid; other site 1124983008696 ABC transporter signature motif; other site 1124983008697 Walker B; other site 1124983008698 D-loop; other site 1124983008699 H-loop/switch region; other site 1124983008700 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1124983008701 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1124983008702 Walker A/P-loop; other site 1124983008703 ATP binding site [chemical binding]; other site 1124983008704 Q-loop/lid; other site 1124983008705 ABC transporter signature motif; other site 1124983008706 Walker B; other site 1124983008707 D-loop; other site 1124983008708 H-loop/switch region; other site 1124983008709 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1124983008710 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124983008711 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1124983008712 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124983008713 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1124983008714 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983008715 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983008716 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1124983008717 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1124983008718 putative NAD(P) binding site [chemical binding]; other site 1124983008719 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983008720 TAP-like protein; Region: Abhydrolase_4; pfam08386 1124983008721 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1124983008722 classical (c) SDRs; Region: SDR_c; cd05233 1124983008723 NAD(P) binding site [chemical binding]; other site 1124983008724 active site 1124983008725 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1124983008726 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1124983008727 FMN binding site [chemical binding]; other site 1124983008728 active site 1124983008729 substrate binding site [chemical binding]; other site 1124983008730 catalytic residue [active] 1124983008731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983008732 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1124983008733 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983008734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983008735 DNA binding residues [nucleotide binding] 1124983008736 dimerization interface [polypeptide binding]; other site 1124983008737 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983008738 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983008739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1124983008740 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1124983008741 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1124983008742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008743 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1124983008744 putative effector binding pocket; other site 1124983008745 putative dimerization interface [polypeptide binding]; other site 1124983008746 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124983008747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983008748 putative substrate translocation pore; other site 1124983008749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1124983008750 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1124983008751 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1124983008752 Surface antigen; Region: Bac_surface_Ag; pfam01103 1124983008753 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 1124983008754 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1124983008755 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1124983008756 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1124983008757 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1124983008758 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1124983008759 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1124983008760 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1124983008761 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1124983008762 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1124983008763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983008765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983008766 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1124983008767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983008768 Coenzyme A binding pocket [chemical binding]; other site 1124983008769 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1124983008770 aspartate racemase; Region: asp_race; TIGR00035 1124983008771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983008772 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983008773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983008774 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 1124983008775 Low-spin heme binding site [chemical binding]; other site 1124983008776 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1124983008777 D-pathway; other site 1124983008778 Putative water exit pathway; other site 1124983008779 Binuclear center (active site) [active] 1124983008780 K-pathway; other site 1124983008781 Putative proton exit pathway; other site 1124983008782 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1124983008783 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124983008784 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124983008785 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1124983008786 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1124983008787 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 1124983008788 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1124983008789 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1124983008790 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124983008791 HSP70 interaction site [polypeptide binding]; other site 1124983008792 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1124983008793 hydrophobic ligand binding site; other site 1124983008794 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1124983008795 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1124983008796 potential catalytic triad [active] 1124983008797 conserved cys residue [active] 1124983008798 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1124983008799 dimer interface [polypeptide binding]; other site 1124983008800 catalytic triad [active] 1124983008801 peroxidatic and resolving cysteines [active] 1124983008802 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983008803 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983008804 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983008805 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1124983008806 Protein export membrane protein; Region: SecD_SecF; cl14618 1124983008807 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1124983008808 Protein export membrane protein; Region: SecD_SecF; cl14618 1124983008809 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983008810 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1124983008811 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1124983008812 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1124983008813 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983008814 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983008815 metal binding site [ion binding]; metal-binding site 1124983008816 active site 1124983008817 I-site; other site 1124983008818 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983008819 short chain dehydrogenase; Provisional; Region: PRK06123 1124983008820 classical (c) SDRs; Region: SDR_c; cd05233 1124983008821 NAD(P) binding site [chemical binding]; other site 1124983008822 active site 1124983008823 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1124983008824 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1124983008825 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1124983008826 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1124983008827 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983008828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983008829 DNA-binding site [nucleotide binding]; DNA binding site 1124983008830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983008831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983008832 homodimer interface [polypeptide binding]; other site 1124983008833 catalytic residue [active] 1124983008834 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1124983008835 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1124983008836 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1124983008837 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 1124983008838 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1124983008839 MgtC family; Region: MgtC; pfam02308 1124983008840 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1124983008841 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1124983008842 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1124983008843 active site 1124983008844 homodimer interface [polypeptide binding]; other site 1124983008845 catalytic site [active] 1124983008846 acceptor binding site [chemical binding]; other site 1124983008847 trehalose synthase; Region: treS_nterm; TIGR02456 1124983008848 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1124983008849 active site 1124983008850 catalytic site [active] 1124983008851 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1124983008852 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1124983008853 glycogen branching enzyme; Provisional; Region: PRK05402 1124983008854 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1124983008855 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1124983008856 active site 1124983008857 catalytic site [active] 1124983008858 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1124983008859 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1124983008860 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983008861 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1124983008862 putative catalytic site [active] 1124983008863 putative metal binding site [ion binding]; other site 1124983008864 putative phosphate binding site [ion binding]; other site 1124983008865 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1124983008866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983008867 active site 1124983008868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983008869 S-adenosylmethionine binding site [chemical binding]; other site 1124983008870 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1124983008871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983008872 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983008873 active site 1124983008874 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1124983008875 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1124983008876 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1124983008877 active site 1124983008878 catalytic site [active] 1124983008879 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1124983008880 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1124983008881 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1124983008882 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1124983008883 active site 1124983008884 catalytic site [active] 1124983008885 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1124983008886 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1124983008887 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1124983008888 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1124983008889 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1124983008890 catalytic site [active] 1124983008891 active site 1124983008892 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1124983008893 glycogen synthase; Provisional; Region: glgA; PRK00654 1124983008894 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1124983008895 ADP-binding pocket [chemical binding]; other site 1124983008896 homodimer interface [polypeptide binding]; other site 1124983008897 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1124983008898 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1124983008899 dimerization interface [polypeptide binding]; other site 1124983008900 NAD binding site [chemical binding]; other site 1124983008901 ligand binding site [chemical binding]; other site 1124983008902 catalytic site [active] 1124983008903 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983008904 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1124983008905 Predicted membrane protein [Function unknown]; Region: COG1238 1124983008906 Protein of unknown function, DUF; Region: DUF411; cl01142 1124983008907 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1124983008908 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1124983008909 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1124983008910 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1124983008911 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1124983008912 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1124983008913 hydrophobic ligand binding site; other site 1124983008914 HAMP domain; Region: HAMP; pfam00672 1124983008915 dimerization interface [polypeptide binding]; other site 1124983008916 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983008917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983008918 dimer interface [polypeptide binding]; other site 1124983008919 putative CheW interface [polypeptide binding]; other site 1124983008920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124983008921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124983008922 active site 1124983008923 catalytic tetrad [active] 1124983008924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983008926 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1124983008927 putative effector binding pocket; other site 1124983008928 putative dimerization interface [polypeptide binding]; other site 1124983008929 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1124983008930 Penicillin amidase; Region: Penicil_amidase; pfam01804 1124983008931 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1124983008932 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1124983008933 active site 1124983008934 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1124983008935 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983008936 FecR protein; Region: FecR; pfam04773 1124983008937 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1124983008938 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1124983008939 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1124983008940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983008942 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1124983008943 putative substrate binding pocket [chemical binding]; other site 1124983008944 putative dimerization interface [polypeptide binding]; other site 1124983008945 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1124983008946 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124983008947 putative active site [active] 1124983008948 catalytic triad [active] 1124983008949 putative dimer interface [polypeptide binding]; other site 1124983008950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983008951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983008953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983008954 dimerization interface [polypeptide binding]; other site 1124983008955 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983008956 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1124983008957 NAD(P) binding site [chemical binding]; other site 1124983008958 catalytic residues [active] 1124983008959 catalytic residues [active] 1124983008960 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1124983008961 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1124983008962 putative active site [active] 1124983008963 metal binding site [ion binding]; metal-binding site 1124983008964 Amino acid permease; Region: AA_permease_2; pfam13520 1124983008965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983008966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983008967 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1124983008968 putative effector binding pocket; other site 1124983008969 putative dimerization interface [polypeptide binding]; other site 1124983008970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983008971 putative substrate translocation pore; other site 1124983008972 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1124983008973 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1124983008974 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1124983008975 FAD binding pocket [chemical binding]; other site 1124983008976 FAD binding motif [chemical binding]; other site 1124983008977 phosphate binding motif [ion binding]; other site 1124983008978 beta-alpha-beta structure motif; other site 1124983008979 NAD binding pocket [chemical binding]; other site 1124983008980 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1124983008981 active site 1124983008982 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1124983008983 dimer interface [polypeptide binding]; other site 1124983008984 non-prolyl cis peptide bond; other site 1124983008985 insertion regions; other site 1124983008986 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1124983008987 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124983008988 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124983008989 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1124983008990 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1124983008991 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1124983008992 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1124983008993 active site 1124983008994 dimer interface [polypeptide binding]; other site 1124983008995 non-prolyl cis peptide bond; other site 1124983008996 insertion regions; other site 1124983008997 Secretory lipase; Region: LIP; pfam03583 1124983008998 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1124983008999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1124983009000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983009001 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1124983009002 Walker A motif; other site 1124983009003 ATP binding site [chemical binding]; other site 1124983009004 Walker B motif; other site 1124983009005 arginine finger; other site 1124983009006 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1124983009007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983009008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983009009 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1124983009010 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1124983009011 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1124983009012 NAD binding site [chemical binding]; other site 1124983009013 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124983009014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983009015 putative substrate translocation pore; other site 1124983009016 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1124983009017 conserved cys residue [active] 1124983009018 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1124983009019 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1124983009020 short chain dehydrogenase; Provisional; Region: PRK07832 1124983009021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983009022 NAD(P) binding site [chemical binding]; other site 1124983009023 active site 1124983009024 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1124983009025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1124983009026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983009027 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1124983009028 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1124983009029 Di-iron ligands [ion binding]; other site 1124983009030 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1124983009031 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 1124983009032 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983009033 active site 1124983009034 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1124983009035 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1124983009036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983009037 NAD(P) binding site [chemical binding]; other site 1124983009038 active site 1124983009039 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1124983009040 active site 2 [active] 1124983009041 active site 1 [active] 1124983009042 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1124983009043 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983009044 dimer interface [polypeptide binding]; other site 1124983009045 active site 1124983009046 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1124983009047 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1124983009048 acyl-activating enzyme (AAE) consensus motif; other site 1124983009049 putative AMP binding site [chemical binding]; other site 1124983009050 putative active site [active] 1124983009051 putative CoA binding site [chemical binding]; other site 1124983009052 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983009053 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1124983009054 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983009055 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1124983009056 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124983009057 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1124983009058 FtsX-like permease family; Region: FtsX; pfam02687 1124983009059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1124983009060 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124983009061 Walker A/P-loop; other site 1124983009062 ATP binding site [chemical binding]; other site 1124983009063 Q-loop/lid; other site 1124983009064 ABC transporter signature motif; other site 1124983009065 Walker B; other site 1124983009066 D-loop; other site 1124983009067 H-loop/switch region; other site 1124983009068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983009069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983009070 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983009071 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1124983009072 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983009073 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983009074 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983009075 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983009076 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1124983009077 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124983009078 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983009079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983009080 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983009081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983009082 substrate binding pocket [chemical binding]; other site 1124983009083 membrane-bound complex binding site; other site 1124983009084 hinge residues; other site 1124983009085 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983009086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983009087 substrate binding pocket [chemical binding]; other site 1124983009088 membrane-bound complex binding site; other site 1124983009089 hinge residues; other site 1124983009090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983009091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983009092 dimer interface [polypeptide binding]; other site 1124983009093 phosphorylation site [posttranslational modification] 1124983009094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983009095 ATP binding site [chemical binding]; other site 1124983009096 Mg2+ binding site [ion binding]; other site 1124983009097 G-X-G motif; other site 1124983009098 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983009099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009100 active site 1124983009101 phosphorylation site [posttranslational modification] 1124983009102 intermolecular recognition site; other site 1124983009103 dimerization interface [polypeptide binding]; other site 1124983009104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983009105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009106 active site 1124983009107 phosphorylation site [posttranslational modification] 1124983009108 intermolecular recognition site; other site 1124983009109 dimerization interface [polypeptide binding]; other site 1124983009110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983009111 DNA binding residues [nucleotide binding] 1124983009112 dimerization interface [polypeptide binding]; other site 1124983009113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983009114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983009115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009116 active site 1124983009117 phosphorylation site [posttranslational modification] 1124983009118 intermolecular recognition site; other site 1124983009119 dimerization interface [polypeptide binding]; other site 1124983009120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983009121 DNA binding residues [nucleotide binding] 1124983009122 dimerization interface [polypeptide binding]; other site 1124983009123 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1124983009124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124983009125 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124983009126 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1124983009127 Peptidase family U32; Region: Peptidase_U32; pfam01136 1124983009128 Collagenase; Region: DUF3656; pfam12392 1124983009129 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1124983009130 homotrimer interaction site [polypeptide binding]; other site 1124983009131 putative active site [active] 1124983009132 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983009133 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983009134 N-terminal plug; other site 1124983009135 ligand-binding site [chemical binding]; other site 1124983009136 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983009137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983009138 NAD(P) binding site [chemical binding]; other site 1124983009139 active site 1124983009140 Uncharacterized conserved protein [Function unknown]; Region: COG3868 1124983009141 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 1124983009142 putative active site [active] 1124983009143 Tetratricopeptide repeat; Region: TPR_15; pfam13429 1124983009144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983009145 TPR motif; other site 1124983009146 binding surface 1124983009147 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1124983009148 GAF domain; Region: GAF_3; pfam13492 1124983009149 HEAT repeats; Region: HEAT_2; pfam13646 1124983009150 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 1124983009151 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983009152 Predicted membrane protein [Function unknown]; Region: COG4267 1124983009153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983009154 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983009155 substrate binding pocket [chemical binding]; other site 1124983009156 membrane-bound complex binding site; other site 1124983009157 hinge residues; other site 1124983009158 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1124983009159 putative active site [active] 1124983009160 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1124983009161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983009162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983009163 Walker A/P-loop; other site 1124983009164 ATP binding site [chemical binding]; other site 1124983009165 Q-loop/lid; other site 1124983009166 ABC transporter signature motif; other site 1124983009167 Walker B; other site 1124983009168 D-loop; other site 1124983009169 H-loop/switch region; other site 1124983009170 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1124983009171 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983009172 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983009173 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1124983009174 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1124983009175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983009176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983009177 Walker A/P-loop; other site 1124983009178 ATP binding site [chemical binding]; other site 1124983009179 Q-loop/lid; other site 1124983009180 ABC transporter signature motif; other site 1124983009181 Walker B; other site 1124983009182 D-loop; other site 1124983009183 H-loop/switch region; other site 1124983009184 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 1124983009185 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1124983009186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983009187 putative active site [active] 1124983009188 PAS fold; Region: PAS_3; pfam08447 1124983009189 heme pocket [chemical binding]; other site 1124983009190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983009191 dimer interface [polypeptide binding]; other site 1124983009192 phosphorylation site [posttranslational modification] 1124983009193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983009194 ATP binding site [chemical binding]; other site 1124983009195 Mg2+ binding site [ion binding]; other site 1124983009196 G-X-G motif; other site 1124983009197 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983009198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009199 active site 1124983009200 phosphorylation site [posttranslational modification] 1124983009201 intermolecular recognition site; other site 1124983009202 dimerization interface [polypeptide binding]; other site 1124983009203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983009204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983009205 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983009206 putative effector binding pocket; other site 1124983009207 dimerization interface [polypeptide binding]; other site 1124983009208 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983009209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009210 active site 1124983009211 phosphorylation site [posttranslational modification] 1124983009212 intermolecular recognition site; other site 1124983009213 dimerization interface [polypeptide binding]; other site 1124983009214 conserved hypothetical protein; Region: TIGR02270 1124983009215 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1124983009216 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1124983009217 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 1124983009218 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1124983009219 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1124983009220 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1124983009221 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1124983009222 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1124983009223 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1124983009224 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1124983009225 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124983009226 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1124983009227 RNA ligase; Region: RNA_ligase; pfam09414 1124983009228 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983009229 Zn2+ binding site [ion binding]; other site 1124983009230 Mg2+ binding site [ion binding]; other site 1124983009231 AAA domain; Region: AAA_33; pfam13671 1124983009232 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1124983009233 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1124983009234 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1124983009235 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983009236 substrate binding site [chemical binding]; other site 1124983009237 oxyanion hole (OAH) forming residues; other site 1124983009238 trimer interface [polypeptide binding]; other site 1124983009239 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 1124983009240 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1124983009241 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983009242 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983009243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983009244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983009245 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983009246 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1124983009247 nudix motif; other site 1124983009248 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1124983009249 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1124983009250 Cu(I) binding site [ion binding]; other site 1124983009251 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1124983009252 AAA domain; Region: AAA_21; pfam13304 1124983009253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1124983009254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983009255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983009256 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1124983009257 substrate binding pocket [chemical binding]; other site 1124983009258 dimerization interface [polypeptide binding]; other site 1124983009259 acyl-CoA synthetase; Validated; Region: PRK06178 1124983009260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983009261 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 1124983009262 acyl-activating enzyme (AAE) consensus motif; other site 1124983009263 putative AMP binding site [chemical binding]; other site 1124983009264 putative active site [active] 1124983009265 putative CoA binding site [chemical binding]; other site 1124983009266 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1124983009267 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124983009268 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1124983009269 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1124983009270 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1124983009271 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124983009272 carboxyltransferase (CT) interaction site; other site 1124983009273 biotinylation site [posttranslational modification]; other site 1124983009274 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1124983009275 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1124983009276 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1124983009277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983009278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983009279 putative substrate translocation pore; other site 1124983009280 Predicted transcriptional regulator [Transcription]; Region: COG2345 1124983009281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1124983009282 putative DNA binding site [nucleotide binding]; other site 1124983009283 putative Zn2+ binding site [ion binding]; other site 1124983009284 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1124983009285 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983009286 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983009287 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1124983009288 NAD(P) binding site [chemical binding]; other site 1124983009289 catalytic residues [active] 1124983009290 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1124983009291 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124983009292 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1124983009293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009294 dimer interface [polypeptide binding]; other site 1124983009295 conserved gate region; other site 1124983009296 ABC-ATPase subunit interface; other site 1124983009297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009298 dimer interface [polypeptide binding]; other site 1124983009299 conserved gate region; other site 1124983009300 putative PBP binding loops; other site 1124983009301 ABC-ATPase subunit interface; other site 1124983009302 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1124983009303 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1124983009304 Walker A/P-loop; other site 1124983009305 ATP binding site [chemical binding]; other site 1124983009306 Q-loop/lid; other site 1124983009307 ABC transporter signature motif; other site 1124983009308 Walker B; other site 1124983009309 D-loop; other site 1124983009310 H-loop/switch region; other site 1124983009311 TOBE domain; Region: TOBE_2; pfam08402 1124983009312 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983009313 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1124983009314 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124983009315 active site 1124983009316 DNA binding site [nucleotide binding] 1124983009317 Int/Topo IB signature motif; other site 1124983009318 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1124983009319 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1124983009320 inhibitor-cofactor binding pocket; inhibition site 1124983009321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983009322 catalytic residue [active] 1124983009323 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1124983009324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983009325 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1124983009326 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1124983009327 active site 1124983009328 substrate binding site [chemical binding]; other site 1124983009329 cosubstrate binding site; other site 1124983009330 catalytic site [active] 1124983009331 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1124983009332 active site 1124983009333 hexamer interface [polypeptide binding]; other site 1124983009334 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1124983009335 NAD binding site [chemical binding]; other site 1124983009336 substrate binding site [chemical binding]; other site 1124983009337 active site 1124983009338 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1124983009339 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1124983009340 putative active site [active] 1124983009341 putative catalytic site [active] 1124983009342 putative Zn binding site [ion binding]; other site 1124983009343 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1124983009344 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1124983009345 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1124983009346 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1124983009347 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1124983009348 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1124983009349 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1124983009350 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1124983009351 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1124983009352 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983009353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983009354 Coenzyme A binding pocket [chemical binding]; other site 1124983009355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983009356 HPP family; Region: HPP; pfam04982 1124983009357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983009358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983009359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983009360 dimerization interface [polypeptide binding]; other site 1124983009361 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1124983009362 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1124983009363 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1124983009364 Amidinotransferase; Region: Amidinotransf; pfam02274 1124983009365 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1124983009366 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1124983009367 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983009368 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1124983009369 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983009370 Walker A/P-loop; other site 1124983009371 ATP binding site [chemical binding]; other site 1124983009372 Q-loop/lid; other site 1124983009373 ABC transporter signature motif; other site 1124983009374 Walker B; other site 1124983009375 D-loop; other site 1124983009376 H-loop/switch region; other site 1124983009377 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983009378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009379 dimer interface [polypeptide binding]; other site 1124983009380 conserved gate region; other site 1124983009381 putative PBP binding loops; other site 1124983009382 ABC-ATPase subunit interface; other site 1124983009383 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983009384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009385 dimer interface [polypeptide binding]; other site 1124983009386 conserved gate region; other site 1124983009387 putative PBP binding loops; other site 1124983009388 ABC-ATPase subunit interface; other site 1124983009389 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1124983009390 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983009391 substrate binding pocket [chemical binding]; other site 1124983009392 membrane-bound complex binding site; other site 1124983009393 hinge residues; other site 1124983009394 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1124983009395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983009396 substrate binding site [chemical binding]; other site 1124983009397 oxyanion hole (OAH) forming residues; other site 1124983009398 trimer interface [polypeptide binding]; other site 1124983009399 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1124983009400 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983009401 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983009402 active site 1124983009403 enoyl-CoA hydratase; Provisional; Region: PRK05862 1124983009404 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983009405 substrate binding site [chemical binding]; other site 1124983009406 oxyanion hole (OAH) forming residues; other site 1124983009407 trimer interface [polypeptide binding]; other site 1124983009408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983009409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983009410 active site 1124983009411 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1124983009412 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983009413 dimer interface [polypeptide binding]; other site 1124983009414 active site 1124983009415 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1124983009416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983009417 NAD(P) binding site [chemical binding]; other site 1124983009418 active site 1124983009419 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1124983009420 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983009421 acyl-activating enzyme (AAE) consensus motif; other site 1124983009422 AMP binding site [chemical binding]; other site 1124983009423 active site 1124983009424 CoA binding site [chemical binding]; other site 1124983009425 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983009426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983009427 SurA N-terminal domain; Region: SurA_N; pfam09312 1124983009428 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1124983009429 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983009430 N-terminal plug; other site 1124983009431 ligand-binding site [chemical binding]; other site 1124983009432 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1124983009433 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1124983009434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009435 dimer interface [polypeptide binding]; other site 1124983009436 conserved gate region; other site 1124983009437 putative PBP binding loops; other site 1124983009438 ABC-ATPase subunit interface; other site 1124983009439 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1124983009440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009441 dimer interface [polypeptide binding]; other site 1124983009442 conserved gate region; other site 1124983009443 putative PBP binding loops; other site 1124983009444 ABC-ATPase subunit interface; other site 1124983009445 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1124983009446 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1124983009447 Walker A/P-loop; other site 1124983009448 ATP binding site [chemical binding]; other site 1124983009449 Q-loop/lid; other site 1124983009450 ABC transporter signature motif; other site 1124983009451 Walker B; other site 1124983009452 D-loop; other site 1124983009453 H-loop/switch region; other site 1124983009454 TOBE domain; Region: TOBE; pfam03459 1124983009455 TOBE domain; Region: TOBE_2; pfam08402 1124983009456 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1124983009457 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1124983009458 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1124983009459 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1124983009460 N- and C-terminal domain interface [polypeptide binding]; other site 1124983009461 D-xylulose kinase; Region: XylB; TIGR01312 1124983009462 active site 1124983009463 MgATP binding site [chemical binding]; other site 1124983009464 catalytic site [active] 1124983009465 metal binding site [ion binding]; metal-binding site 1124983009466 xylulose binding site [chemical binding]; other site 1124983009467 putative homodimer interface [polypeptide binding]; other site 1124983009468 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1124983009469 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124983009470 putative substrate binding site [chemical binding]; other site 1124983009471 putative ATP binding site [chemical binding]; other site 1124983009472 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983009473 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1124983009474 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124983009475 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1124983009476 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1124983009477 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983009478 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1124983009479 putative NAD(P) binding site [chemical binding]; other site 1124983009480 active site 1124983009481 putative substrate binding site [chemical binding]; other site 1124983009482 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1124983009483 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1124983009484 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1124983009485 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1124983009486 SLBB domain; Region: SLBB; pfam10531 1124983009487 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1124983009488 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1124983009489 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1124983009490 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1124983009491 O-Antigen ligase; Region: Wzy_C; pfam04932 1124983009492 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983009493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1124983009494 active site 1124983009495 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1124983009496 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983009497 DXD motif; other site 1124983009498 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1124983009499 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1124983009500 putative active site [active] 1124983009501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983009502 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1124983009503 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1124983009504 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1124983009505 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1124983009506 ecotin; Provisional; Region: PRK03719 1124983009507 secondary substrate binding site; other site 1124983009508 primary substrate binding site; other site 1124983009509 inhibition loop; other site 1124983009510 dimerization interface [polypeptide binding]; other site 1124983009511 NIPSNAP; Region: NIPSNAP; pfam07978 1124983009512 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1124983009513 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1124983009514 tetramer interface [polypeptide binding]; other site 1124983009515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983009516 catalytic residue [active] 1124983009517 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1124983009518 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1124983009519 active site 1124983009520 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1124983009521 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1124983009522 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1124983009523 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983009524 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983009525 Peptidase_C39 like family; Region: DUF3335; pfam11814 1124983009526 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1124983009527 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1124983009528 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1124983009529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983009530 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983009531 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1124983009532 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983009533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983009534 Walker A/P-loop; other site 1124983009535 ATP binding site [chemical binding]; other site 1124983009536 ABC transporter signature motif; other site 1124983009537 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983009538 Walker B; other site 1124983009539 ABC transporter; Region: ABC_tran_2; pfam12848 1124983009540 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983009541 major facilitator superfamily transporter; Provisional; Region: PRK05122 1124983009542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983009543 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1124983009544 azoreductase; Reviewed; Region: PRK00170 1124983009545 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983009546 LysR family transcriptional regulator; Provisional; Region: PRK14997 1124983009547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983009548 dimerization interface [polypeptide binding]; other site 1124983009549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1124983009550 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1124983009551 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1124983009552 Cache domain; Region: Cache_2; pfam08269 1124983009553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983009554 dimerization interface [polypeptide binding]; other site 1124983009555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983009556 dimer interface [polypeptide binding]; other site 1124983009557 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1124983009558 putative CheW interface [polypeptide binding]; other site 1124983009559 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1124983009560 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1124983009561 putative active site [active] 1124983009562 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983009563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983009564 Walker A motif; other site 1124983009565 ATP binding site [chemical binding]; other site 1124983009566 Walker B motif; other site 1124983009567 arginine finger; other site 1124983009568 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983009569 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1124983009570 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1124983009571 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1124983009572 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1124983009573 Chlorophyllase enzyme; Region: Chlorophyllase2; pfam12740 1124983009574 PaaX-like protein; Region: PaaX; pfam07848 1124983009575 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1124983009576 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1124983009577 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1124983009578 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1124983009579 putative trimer interface [polypeptide binding]; other site 1124983009580 putative metal binding site [ion binding]; other site 1124983009581 enoyl-CoA hydratase; Provisional; Region: PRK08140 1124983009582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983009583 substrate binding site [chemical binding]; other site 1124983009584 oxyanion hole (OAH) forming residues; other site 1124983009585 trimer interface [polypeptide binding]; other site 1124983009586 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1124983009587 CoenzymeA binding site [chemical binding]; other site 1124983009588 subunit interaction site [polypeptide binding]; other site 1124983009589 PHB binding site; other site 1124983009590 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1124983009591 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1124983009592 active site 1124983009593 AMP binding site [chemical binding]; other site 1124983009594 homodimer interface [polypeptide binding]; other site 1124983009595 acyl-activating enzyme (AAE) consensus motif; other site 1124983009596 CoA binding site [chemical binding]; other site 1124983009597 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1124983009598 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1124983009599 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1124983009600 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1124983009601 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1124983009602 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1124983009603 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1124983009604 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1124983009605 FAD binding pocket [chemical binding]; other site 1124983009606 FAD binding motif [chemical binding]; other site 1124983009607 phosphate binding motif [ion binding]; other site 1124983009608 beta-alpha-beta structure motif; other site 1124983009609 NAD(p) ribose binding residues [chemical binding]; other site 1124983009610 NAD binding pocket [chemical binding]; other site 1124983009611 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1124983009612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983009613 catalytic loop [active] 1124983009614 iron binding site [ion binding]; other site 1124983009615 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1124983009616 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1124983009617 Na binding site [ion binding]; other site 1124983009618 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1124983009619 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1124983009620 substrate binding site [chemical binding]; other site 1124983009621 dimer interface [polypeptide binding]; other site 1124983009622 NADP binding site [chemical binding]; other site 1124983009623 catalytic residues [active] 1124983009624 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1124983009625 substrate binding site [chemical binding]; other site 1124983009626 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1124983009627 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1124983009628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983009629 active site 1124983009630 motif I; other site 1124983009631 motif II; other site 1124983009632 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1124983009633 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1124983009634 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1124983009635 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1124983009636 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124983009637 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1124983009638 hypothetical protein; Provisional; Region: PRK10649 1124983009639 Sulfatase; Region: Sulfatase; pfam00884 1124983009640 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1124983009641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009642 active site 1124983009643 phosphorylation site [posttranslational modification] 1124983009644 intermolecular recognition site; other site 1124983009645 dimerization interface [polypeptide binding]; other site 1124983009646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983009647 DNA binding site [nucleotide binding] 1124983009648 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1124983009649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983009650 dimerization interface [polypeptide binding]; other site 1124983009651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983009652 dimer interface [polypeptide binding]; other site 1124983009653 phosphorylation site [posttranslational modification] 1124983009654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983009655 ATP binding site [chemical binding]; other site 1124983009656 Mg2+ binding site [ion binding]; other site 1124983009657 G-X-G motif; other site 1124983009658 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1124983009659 Chromate transporter; Region: Chromate_transp; pfam02417 1124983009660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983009661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983009662 Coenzyme A binding pocket [chemical binding]; other site 1124983009663 Predicted ATPase [General function prediction only]; Region: COG1485 1124983009664 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1124983009665 Predicted transcriptional regulator [Transcription]; Region: COG2378 1124983009666 HTH domain; Region: HTH_11; pfam08279 1124983009667 WYL domain; Region: WYL; pfam13280 1124983009668 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983009669 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983009670 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983009671 N-terminal plug; other site 1124983009672 ligand-binding site [chemical binding]; other site 1124983009673 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983009674 FecR protein; Region: FecR; pfam04773 1124983009675 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1124983009676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983009677 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983009678 DNA binding residues [nucleotide binding] 1124983009679 xanthine permease; Region: pbuX; TIGR03173 1124983009680 Water Stress and Hypersensitive response; Region: WHy; smart00769 1124983009681 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1124983009682 glutaminase; Provisional; Region: PRK00971 1124983009683 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1124983009684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983009685 Walker A/P-loop; other site 1124983009686 ATP binding site [chemical binding]; other site 1124983009687 Q-loop/lid; other site 1124983009688 ABC transporter signature motif; other site 1124983009689 Walker B; other site 1124983009690 D-loop; other site 1124983009691 H-loop/switch region; other site 1124983009692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983009693 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983009694 Walker A/P-loop; other site 1124983009695 ATP binding site [chemical binding]; other site 1124983009696 Q-loop/lid; other site 1124983009697 ABC transporter signature motif; other site 1124983009698 Walker B; other site 1124983009699 D-loop; other site 1124983009700 H-loop/switch region; other site 1124983009701 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983009702 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1124983009703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009704 dimer interface [polypeptide binding]; other site 1124983009705 conserved gate region; other site 1124983009706 putative PBP binding loops; other site 1124983009707 ABC-ATPase subunit interface; other site 1124983009708 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1124983009709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1124983009710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009711 dimer interface [polypeptide binding]; other site 1124983009712 conserved gate region; other site 1124983009713 putative PBP binding loops; other site 1124983009714 ABC-ATPase subunit interface; other site 1124983009715 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1124983009716 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1124983009717 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1124983009718 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1124983009719 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1124983009720 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1124983009721 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983009722 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1124983009723 active site 1124983009724 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1124983009725 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983009726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983009727 Walker A/P-loop; other site 1124983009728 ATP binding site [chemical binding]; other site 1124983009729 Q-loop/lid; other site 1124983009730 ABC transporter signature motif; other site 1124983009731 Walker B; other site 1124983009732 D-loop; other site 1124983009733 H-loop/switch region; other site 1124983009734 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1124983009735 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983009736 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1124983009737 Walker A/P-loop; other site 1124983009738 ATP binding site [chemical binding]; other site 1124983009739 Q-loop/lid; other site 1124983009740 ABC transporter signature motif; other site 1124983009741 Walker B; other site 1124983009742 D-loop; other site 1124983009743 H-loop/switch region; other site 1124983009744 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1124983009745 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1124983009746 active site 1124983009747 dimer interface [polypeptide binding]; other site 1124983009748 non-prolyl cis peptide bond; other site 1124983009749 insertion regions; other site 1124983009750 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1124983009751 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1124983009752 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124983009753 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983009754 N-terminal plug; other site 1124983009755 ligand-binding site [chemical binding]; other site 1124983009756 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124983009757 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983009758 N-terminal plug; other site 1124983009759 ligand-binding site [chemical binding]; other site 1124983009760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1124983009761 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1124983009762 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1124983009763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009764 dimer interface [polypeptide binding]; other site 1124983009765 conserved gate region; other site 1124983009766 putative PBP binding loops; other site 1124983009767 ABC-ATPase subunit interface; other site 1124983009768 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1124983009769 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1124983009770 Walker A/P-loop; other site 1124983009771 ATP binding site [chemical binding]; other site 1124983009772 Q-loop/lid; other site 1124983009773 ABC transporter signature motif; other site 1124983009774 Walker B; other site 1124983009775 D-loop; other site 1124983009776 H-loop/switch region; other site 1124983009777 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1124983009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983009779 dimer interface [polypeptide binding]; other site 1124983009780 conserved gate region; other site 1124983009781 putative PBP binding loops; other site 1124983009782 ABC-ATPase subunit interface; other site 1124983009783 NMT1-like family; Region: NMT1_2; pfam13379 1124983009784 NMT1/THI5 like; Region: NMT1; pfam09084 1124983009785 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1124983009786 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1124983009787 Walker A/P-loop; other site 1124983009788 ATP binding site [chemical binding]; other site 1124983009789 Q-loop/lid; other site 1124983009790 ABC transporter signature motif; other site 1124983009791 Walker B; other site 1124983009792 D-loop; other site 1124983009793 H-loop/switch region; other site 1124983009794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983009795 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1124983009796 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983009797 active site 1124983009798 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1124983009799 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1124983009800 Cupin; Region: Cupin_6; pfam12852 1124983009801 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983009802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983009803 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1124983009804 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983009805 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1124983009806 Walker A/P-loop; other site 1124983009807 ATP binding site [chemical binding]; other site 1124983009808 Q-loop/lid; other site 1124983009809 ABC transporter signature motif; other site 1124983009810 Walker B; other site 1124983009811 D-loop; other site 1124983009812 H-loop/switch region; other site 1124983009813 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1124983009814 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1124983009815 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1124983009816 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1124983009817 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1124983009818 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1124983009819 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124983009820 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124983009821 active site 1124983009822 catalytic tetrad [active] 1124983009823 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1124983009824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983009825 dimer interface [polypeptide binding]; other site 1124983009826 phosphorylation site [posttranslational modification] 1124983009827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983009828 ATP binding site [chemical binding]; other site 1124983009829 Mg2+ binding site [ion binding]; other site 1124983009830 G-X-G motif; other site 1124983009831 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983009832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009833 active site 1124983009834 phosphorylation site [posttranslational modification] 1124983009835 intermolecular recognition site; other site 1124983009836 dimerization interface [polypeptide binding]; other site 1124983009837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009838 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983009839 active site 1124983009840 phosphorylation site [posttranslational modification] 1124983009841 intermolecular recognition site; other site 1124983009842 dimerization interface [polypeptide binding]; other site 1124983009843 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983009844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983009845 dimer interface [polypeptide binding]; other site 1124983009846 phosphorylation site [posttranslational modification] 1124983009847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983009848 ATP binding site [chemical binding]; other site 1124983009849 Mg2+ binding site [ion binding]; other site 1124983009850 G-X-G motif; other site 1124983009851 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983009852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009853 active site 1124983009854 phosphorylation site [posttranslational modification] 1124983009855 intermolecular recognition site; other site 1124983009856 dimerization interface [polypeptide binding]; other site 1124983009857 Hpt domain; Region: Hpt; pfam01627 1124983009858 putative binding surface; other site 1124983009859 active site 1124983009860 transcriptional regulator RcsB; Provisional; Region: PRK10840 1124983009861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983009862 active site 1124983009863 phosphorylation site [posttranslational modification] 1124983009864 intermolecular recognition site; other site 1124983009865 dimerization interface [polypeptide binding]; other site 1124983009866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983009867 DNA binding residues [nucleotide binding] 1124983009868 dimerization interface [polypeptide binding]; other site 1124983009869 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 1124983009870 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1124983009871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1124983009872 DEAD_2; Region: DEAD_2; pfam06733 1124983009873 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1124983009874 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1124983009875 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1124983009876 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1124983009877 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1124983009878 catalytic triad [active] 1124983009879 putative active site [active] 1124983009880 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1124983009881 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1124983009882 Autotransporter beta-domain; Region: Autotransporter; smart00869 1124983009883 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1124983009884 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1124983009885 catalytic triad [active] 1124983009886 putative active site [active] 1124983009887 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1124983009888 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1124983009889 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1124983009890 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1124983009891 nucleophilic elbow; other site 1124983009892 catalytic triad; other site 1124983009893 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1124983009894 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1124983009895 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124983009896 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983009897 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1124983009898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983009899 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1124983009900 Walker A/P-loop; other site 1124983009901 ATP binding site [chemical binding]; other site 1124983009902 Q-loop/lid; other site 1124983009903 ABC transporter signature motif; other site 1124983009904 Walker B; other site 1124983009905 D-loop; other site 1124983009906 H-loop/switch region; other site 1124983009907 Protease inhibitor Inh; Region: Inh; pfam02974 1124983009908 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1124983009909 active site 1124983009910 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1124983009911 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1124983009912 homodimer interface [polypeptide binding]; other site 1124983009913 homotetramer interface [polypeptide binding]; other site 1124983009914 active site pocket [active] 1124983009915 cleavage site 1124983009916 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1124983009917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983009918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983009919 DNA binding residues [nucleotide binding] 1124983009920 dimerization interface [polypeptide binding]; other site 1124983009921 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1124983009922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983009923 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1124983009924 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1124983009925 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1124983009926 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983009927 NAD(P) binding site [chemical binding]; other site 1124983009928 catalytic residues [active] 1124983009929 hypothetical protein; Provisional; Region: PRK07481 1124983009930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983009931 inhibitor-cofactor binding pocket; inhibition site 1124983009932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983009933 catalytic residue [active] 1124983009934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983009935 ABC transporter signature motif; other site 1124983009936 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983009937 Walker B; other site 1124983009938 D-loop; other site 1124983009939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983009940 DNA binding residues [nucleotide binding] 1124983009941 dimerization interface [polypeptide binding]; other site 1124983009942 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1124983009943 aminotransferase; Validated; Region: PRK07046 1124983009944 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983009945 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983009946 catalytic residue [active] 1124983009947 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1124983009948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983009949 NAD(P) binding site [chemical binding]; other site 1124983009950 active site 1124983009951 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983009952 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983009953 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1124983009954 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983009955 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983009956 SnoaL-like domain; Region: SnoaL_2; pfam12680 1124983009957 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983009958 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983009959 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1124983009960 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1124983009961 Family description; Region: UvrD_C_2; pfam13538 1124983009962 Pirin-related protein [General function prediction only]; Region: COG1741 1124983009963 Pirin; Region: Pirin; pfam02678 1124983009964 phosphoglucomutase; Validated; Region: PRK07564 1124983009965 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1124983009966 active site 1124983009967 substrate binding site [chemical binding]; other site 1124983009968 metal binding site [ion binding]; metal-binding site 1124983009969 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1124983009970 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1124983009971 putative NAD(P) binding site [chemical binding]; other site 1124983009972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983009973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983009974 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1124983009975 putative substrate binding pocket [chemical binding]; other site 1124983009976 putative dimerization interface [polypeptide binding]; other site 1124983009977 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1124983009978 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1124983009979 [4Fe-4S] binding site [ion binding]; other site 1124983009980 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124983009981 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1124983009982 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1124983009983 molybdopterin cofactor binding site; other site 1124983009984 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1124983009985 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1124983009986 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1124983009987 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1124983009988 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1124983009989 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1124983009990 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983009991 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983009992 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983009993 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1124983009994 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1124983009995 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1124983009996 HEAT repeats; Region: HEAT_2; pfam13646 1124983009997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983009998 TPR motif; other site 1124983009999 binding surface 1124983010000 circadian clock protein KaiC; Reviewed; Region: PRK09302 1124983010001 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124983010002 Walker A motif; other site 1124983010003 ATP binding site [chemical binding]; other site 1124983010004 Walker B motif; other site 1124983010005 recA bacterial DNA recombination protein; Region: RecA; cl17211 1124983010006 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124983010007 Walker A motif; other site 1124983010008 ATP binding site [chemical binding]; other site 1124983010009 Walker B motif; other site 1124983010010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983010011 ATP binding site [chemical binding]; other site 1124983010012 Mg2+ binding site [ion binding]; other site 1124983010013 G-X-G motif; other site 1124983010014 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983010015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010016 active site 1124983010017 phosphorylation site [posttranslational modification] 1124983010018 intermolecular recognition site; other site 1124983010019 dimerization interface [polypeptide binding]; other site 1124983010020 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983010021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010022 active site 1124983010023 phosphorylation site [posttranslational modification] 1124983010024 intermolecular recognition site; other site 1124983010025 dimerization interface [polypeptide binding]; other site 1124983010026 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983010027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010028 active site 1124983010029 phosphorylation site [posttranslational modification] 1124983010030 intermolecular recognition site; other site 1124983010031 dimerization interface [polypeptide binding]; other site 1124983010032 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983010033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983010034 dimer interface [polypeptide binding]; other site 1124983010035 phosphorylation site [posttranslational modification] 1124983010036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983010037 ATP binding site [chemical binding]; other site 1124983010038 Mg2+ binding site [ion binding]; other site 1124983010039 G-X-G motif; other site 1124983010040 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1124983010041 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1124983010042 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1124983010043 CHASE3 domain; Region: CHASE3; pfam05227 1124983010044 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1124983010045 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1124983010046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983010047 dimer interface [polypeptide binding]; other site 1124983010048 phosphorylation site [posttranslational modification] 1124983010049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983010050 ATP binding site [chemical binding]; other site 1124983010051 Mg2+ binding site [ion binding]; other site 1124983010052 G-X-G motif; other site 1124983010053 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983010054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010055 active site 1124983010056 phosphorylation site [posttranslational modification] 1124983010057 intermolecular recognition site; other site 1124983010058 dimerization interface [polypeptide binding]; other site 1124983010059 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983010060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010061 active site 1124983010062 phosphorylation site [posttranslational modification] 1124983010063 intermolecular recognition site; other site 1124983010064 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983010065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010066 active site 1124983010067 phosphorylation site [posttranslational modification] 1124983010068 intermolecular recognition site; other site 1124983010069 dimerization interface [polypeptide binding]; other site 1124983010070 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983010071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010072 active site 1124983010073 phosphorylation site [posttranslational modification] 1124983010074 intermolecular recognition site; other site 1124983010075 dimerization interface [polypeptide binding]; other site 1124983010076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983010077 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1124983010078 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983010079 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983010080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010082 Iron permease FTR1 family; Region: FTR1; cl00475 1124983010083 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1124983010084 Imelysin; Region: Peptidase_M75; pfam09375 1124983010085 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1124983010086 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1124983010087 Imelysin; Region: Peptidase_M75; pfam09375 1124983010088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983010090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010091 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1124983010092 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1124983010093 domain interface [polypeptide binding]; other site 1124983010094 putative active site [active] 1124983010095 catalytic site [active] 1124983010096 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1124983010097 domain interface [polypeptide binding]; other site 1124983010098 putative active site [active] 1124983010099 catalytic site [active] 1124983010100 putative transcriptional regulator; Provisional; Region: PRK11640 1124983010101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983010102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1124983010103 SnoaL-like domain; Region: SnoaL_2; pfam12680 1124983010104 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1124983010105 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1124983010106 active site 1124983010107 dimer interface [polypeptide binding]; other site 1124983010108 non-prolyl cis peptide bond; other site 1124983010109 insertion regions; other site 1124983010110 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1124983010111 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1124983010112 Flavin binding site [chemical binding]; other site 1124983010113 hypothetical protein; Provisional; Region: PRK10621 1124983010114 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1124983010115 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1124983010116 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1124983010117 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1124983010118 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1124983010119 putative NADH binding site [chemical binding]; other site 1124983010120 putative active site [active] 1124983010121 nudix motif; other site 1124983010122 putative metal binding site [ion binding]; other site 1124983010123 enoyl-CoA hydratase; Provisional; Region: PRK06142 1124983010124 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983010125 substrate binding site [chemical binding]; other site 1124983010126 oxyanion hole (OAH) forming residues; other site 1124983010127 trimer interface [polypeptide binding]; other site 1124983010128 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1124983010129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983010130 S-adenosylmethionine binding site [chemical binding]; other site 1124983010131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983010132 dimer interface [polypeptide binding]; other site 1124983010133 phosphorylation site [posttranslational modification] 1124983010134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983010135 ATP binding site [chemical binding]; other site 1124983010136 Mg2+ binding site [ion binding]; other site 1124983010137 G-X-G motif; other site 1124983010138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983010139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010140 active site 1124983010141 phosphorylation site [posttranslational modification] 1124983010142 intermolecular recognition site; other site 1124983010143 dimerization interface [polypeptide binding]; other site 1124983010144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983010145 DNA binding site [nucleotide binding] 1124983010146 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1124983010147 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983010148 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983010149 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1124983010150 Protein export membrane protein; Region: SecD_SecF; cl14618 1124983010151 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1124983010152 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1124983010153 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1124983010154 putative transporter; Provisional; Region: PRK11660 1124983010155 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1124983010156 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124983010157 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1124983010158 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1124983010159 aminopeptidase N; Provisional; Region: pepN; PRK14015 1124983010160 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1124983010161 active site 1124983010162 Zn binding site [ion binding]; other site 1124983010163 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1124983010164 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 1124983010165 Rhomboid family; Region: Rhomboid; pfam01694 1124983010166 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 1124983010167 active site 1124983010168 metal binding site [ion binding]; metal-binding site 1124983010169 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 1124983010170 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1124983010171 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 1124983010172 arsenical pump membrane protein; Provisional; Region: PRK15445 1124983010173 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1124983010174 transmembrane helices; other site 1124983010175 Predicted flavoprotein [General function prediction only]; Region: COG0431 1124983010176 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983010177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983010178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983010179 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983010180 dimerization interface [polypeptide binding]; other site 1124983010181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983010182 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983010183 Coenzyme A binding pocket [chemical binding]; other site 1124983010184 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1124983010185 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1124983010186 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1124983010187 homodimer interface [polypeptide binding]; other site 1124983010188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983010189 catalytic residue [active] 1124983010190 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1124983010191 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1124983010192 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1124983010193 active site 1124983010194 catalytic site [active] 1124983010195 substrate binding site [chemical binding]; other site 1124983010196 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1124983010197 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1124983010198 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1124983010199 putative active site [active] 1124983010200 catalytic site [active] 1124983010201 putative metal binding site [ion binding]; other site 1124983010202 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1124983010203 RNA/DNA hybrid binding site [nucleotide binding]; other site 1124983010204 active site 1124983010205 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1124983010206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1124983010207 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1124983010208 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1124983010209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124983010210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124983010211 catalytic residue [active] 1124983010212 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124983010213 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1124983010214 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1124983010215 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1124983010216 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1124983010217 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1124983010218 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1124983010219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983010220 dimer interface [polypeptide binding]; other site 1124983010221 conserved gate region; other site 1124983010222 putative PBP binding loops; other site 1124983010223 ABC-ATPase subunit interface; other site 1124983010224 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1124983010225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983010226 dimer interface [polypeptide binding]; other site 1124983010227 conserved gate region; other site 1124983010228 putative PBP binding loops; other site 1124983010229 ABC-ATPase subunit interface; other site 1124983010230 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1124983010231 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983010232 Walker A/P-loop; other site 1124983010233 ATP binding site [chemical binding]; other site 1124983010234 Q-loop/lid; other site 1124983010235 ABC transporter signature motif; other site 1124983010236 Walker B; other site 1124983010237 D-loop; other site 1124983010238 H-loop/switch region; other site 1124983010239 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983010240 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983010241 Walker A/P-loop; other site 1124983010242 ATP binding site [chemical binding]; other site 1124983010243 Q-loop/lid; other site 1124983010244 ABC transporter signature motif; other site 1124983010245 Walker B; other site 1124983010246 D-loop; other site 1124983010247 H-loop/switch region; other site 1124983010248 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983010249 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1124983010250 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1124983010251 NAD binding site [chemical binding]; other site 1124983010252 homotetramer interface [polypeptide binding]; other site 1124983010253 homodimer interface [polypeptide binding]; other site 1124983010254 substrate binding site [chemical binding]; other site 1124983010255 active site 1124983010256 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1124983010257 GAF domain; Region: GAF; pfam01590 1124983010258 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983010259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983010260 metal binding site [ion binding]; metal-binding site 1124983010261 active site 1124983010262 I-site; other site 1124983010263 NnrS protein; Region: NnrS; pfam05940 1124983010264 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1124983010265 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983010266 RNA polymerase sigma factor; Provisional; Region: PRK12528 1124983010267 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983010268 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1124983010269 DNA binding residues [nucleotide binding] 1124983010270 fec operon regulator FecR; Reviewed; Region: PRK09774 1124983010271 FecR protein; Region: FecR; pfam04773 1124983010272 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983010273 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1124983010274 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983010275 N-terminal plug; other site 1124983010276 ligand-binding site [chemical binding]; other site 1124983010277 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1124983010278 dimer interface [polypeptide binding]; other site 1124983010279 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983010280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010281 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983010282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010283 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983010284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983010285 PAS domain; Region: PAS_9; pfam13426 1124983010286 putative active site [active] 1124983010287 heme pocket [chemical binding]; other site 1124983010288 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983010289 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983010290 dimer interface [polypeptide binding]; other site 1124983010291 putative CheW interface [polypeptide binding]; other site 1124983010292 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983010293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983010294 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1124983010295 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1124983010296 dimer interface [polypeptide binding]; other site 1124983010297 active site 1124983010298 catalytic residue [active] 1124983010299 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1124983010300 B1 nucleotide binding pocket [chemical binding]; other site 1124983010301 B2 nucleotide binding pocket [chemical binding]; other site 1124983010302 CAS motifs; other site 1124983010303 active site 1124983010304 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983010305 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1124983010306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010307 active site 1124983010308 phosphorylation site [posttranslational modification] 1124983010309 intermolecular recognition site; other site 1124983010310 dimerization interface [polypeptide binding]; other site 1124983010311 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983010312 Zn2+ binding site [ion binding]; other site 1124983010313 Mg2+ binding site [ion binding]; other site 1124983010314 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983010315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010316 active site 1124983010317 phosphorylation site [posttranslational modification] 1124983010318 intermolecular recognition site; other site 1124983010319 dimerization interface [polypeptide binding]; other site 1124983010320 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983010321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983010322 metal binding site [ion binding]; metal-binding site 1124983010323 active site 1124983010324 I-site; other site 1124983010325 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983010326 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1124983010327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983010328 ATP binding site [chemical binding]; other site 1124983010329 Mg2+ binding site [ion binding]; other site 1124983010330 G-X-G motif; other site 1124983010331 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983010332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010333 active site 1124983010334 phosphorylation site [posttranslational modification] 1124983010335 intermolecular recognition site; other site 1124983010336 dimerization interface [polypeptide binding]; other site 1124983010337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983010338 dimer interface [polypeptide binding]; other site 1124983010339 phosphorylation site [posttranslational modification] 1124983010340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983010341 ATP binding site [chemical binding]; other site 1124983010342 G-X-G motif; other site 1124983010343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1124983010344 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1124983010345 CHASE4 domain; Region: CHASE4; pfam05228 1124983010346 PAS domain S-box; Region: sensory_box; TIGR00229 1124983010347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983010348 putative active site [active] 1124983010349 heme pocket [chemical binding]; other site 1124983010350 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983010351 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983010352 metal binding site [ion binding]; metal-binding site 1124983010353 active site 1124983010354 I-site; other site 1124983010355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983010356 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1124983010357 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1124983010358 dimer interface [polypeptide binding]; other site 1124983010359 ADP-ribose binding site [chemical binding]; other site 1124983010360 active site 1124983010361 nudix motif; other site 1124983010362 metal binding site [ion binding]; metal-binding site 1124983010363 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1124983010364 Predicted membrane protein [Function unknown]; Region: COG4392 1124983010365 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1124983010366 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1124983010367 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1124983010368 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1124983010369 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1124983010370 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1124983010371 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1124983010372 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983010373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983010374 substrate binding pocket [chemical binding]; other site 1124983010375 membrane-bound complex binding site; other site 1124983010376 hinge residues; other site 1124983010377 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 1124983010378 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1124983010379 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1124983010380 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124983010381 hypothetical protein; Provisional; Region: PRK06489 1124983010382 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1124983010383 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1124983010384 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1124983010385 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1124983010386 putative aldolase; Validated; Region: PRK08130 1124983010387 intersubunit interface [polypeptide binding]; other site 1124983010388 active site 1124983010389 Zn2+ binding site [ion binding]; other site 1124983010390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1124983010391 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1124983010392 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1124983010393 magnesium-transporting ATPase; Provisional; Region: PRK15122 1124983010394 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1124983010395 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124983010396 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1124983010397 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1124983010398 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1124983010399 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1124983010400 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1124983010401 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1124983010402 PhoU domain; Region: PhoU; pfam01895 1124983010403 PhoU domain; Region: PhoU; pfam01895 1124983010404 aspartate aminotransferase; Provisional; Region: PRK05764 1124983010405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983010406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983010407 homodimer interface [polypeptide binding]; other site 1124983010408 catalytic residue [active] 1124983010409 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983010410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983010411 dimerization interface [polypeptide binding]; other site 1124983010412 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983010413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983010414 dimer interface [polypeptide binding]; other site 1124983010415 putative CheW interface [polypeptide binding]; other site 1124983010416 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1124983010417 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1124983010418 Flavin Reductases; Region: FlaRed; cl00801 1124983010419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983010420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983010421 dimerization interface [polypeptide binding]; other site 1124983010422 DNA binding residues [nucleotide binding] 1124983010423 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1124983010424 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124983010425 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1124983010426 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1124983010427 active site 1124983010428 Zn binding site [ion binding]; other site 1124983010429 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983010430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010431 Cupin domain; Region: Cupin_2; pfam07883 1124983010432 D-galactonate transporter; Region: 2A0114; TIGR00893 1124983010433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010434 putative substrate translocation pore; other site 1124983010435 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1124983010436 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1124983010437 putative NAD(P) binding site [chemical binding]; other site 1124983010438 catalytic Zn binding site [ion binding]; other site 1124983010439 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1124983010440 choline dehydrogenase; Validated; Region: PRK02106 1124983010441 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1124983010442 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1124983010443 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1124983010444 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983010445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010446 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1124983010447 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1124983010448 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1124983010449 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1124983010450 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1124983010451 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1124983010452 NAD binding site [chemical binding]; other site 1124983010453 catalytic residues [active] 1124983010454 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1124983010455 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1124983010456 putative active site [active] 1124983010457 putative metal binding site [ion binding]; other site 1124983010458 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1124983010459 putative substrate binding pocket [chemical binding]; other site 1124983010460 trimer interface [polypeptide binding]; other site 1124983010461 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1124983010462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010463 putative substrate translocation pore; other site 1124983010464 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1124983010465 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1124983010466 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1124983010467 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1124983010468 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1124983010469 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1124983010470 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1124983010471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010472 putative substrate translocation pore; other site 1124983010473 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1124983010474 dimer interface [polypeptide binding]; other site 1124983010475 putative metal binding site [ion binding]; other site 1124983010476 short chain dehydrogenase; Provisional; Region: PRK07041 1124983010477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983010478 NAD(P) binding site [chemical binding]; other site 1124983010479 active site 1124983010480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983010481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983010482 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983010483 putative effector binding pocket; other site 1124983010484 dimerization interface [polypeptide binding]; other site 1124983010485 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124983010486 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124983010487 active site 1124983010488 catalytic tetrad [active] 1124983010489 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1124983010490 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1124983010491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124983010492 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1124983010493 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1124983010494 dimer interface [polypeptide binding]; other site 1124983010495 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1124983010496 active site 1124983010497 Fe binding site [ion binding]; other site 1124983010498 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983010499 EamA-like transporter family; Region: EamA; pfam00892 1124983010500 EamA-like transporter family; Region: EamA; pfam00892 1124983010501 phage resistance protein; Provisional; Region: PRK10551 1124983010502 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1124983010503 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983010504 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1124983010505 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124983010506 dimer interface [polypeptide binding]; other site 1124983010507 active site 1124983010508 metal binding site [ion binding]; metal-binding site 1124983010509 glutathione binding site [chemical binding]; other site 1124983010510 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1124983010511 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1124983010512 catalytic residue [active] 1124983010513 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1124983010514 catalytic residues [active] 1124983010515 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983010516 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983010517 peroxiredoxin; Region: AhpC; TIGR03137 1124983010518 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1124983010519 dimer interface [polypeptide binding]; other site 1124983010520 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1124983010521 catalytic triad [active] 1124983010522 peroxidatic and resolving cysteines [active] 1124983010523 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1124983010524 DNA binding site [nucleotide binding] 1124983010525 dimer interface [polypeptide binding]; other site 1124983010526 active site 1124983010527 Int/Topo IB signature motif; other site 1124983010528 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1124983010529 glutathione reductase; Validated; Region: PRK06116 1124983010530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983010531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983010532 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1124983010533 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1124983010534 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1124983010535 active site 1124983010536 tetramer interface; other site 1124983010537 Cytochrome c [Energy production and conversion]; Region: COG3258 1124983010538 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983010539 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1124983010540 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983010541 Cytochrome c; Region: Cytochrom_C; cl11414 1124983010542 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1124983010543 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1124983010544 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1124983010545 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1124983010546 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1124983010547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010549 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1124983010550 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1124983010551 DNA binding site [nucleotide binding] 1124983010552 active site 1124983010553 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1124983010554 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1124983010555 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1124983010556 FMN binding site [chemical binding]; other site 1124983010557 substrate binding site [chemical binding]; other site 1124983010558 putative catalytic residue [active] 1124983010559 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1124983010560 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983010561 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1124983010562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983010563 dimer interface [polypeptide binding]; other site 1124983010564 conserved gate region; other site 1124983010565 putative PBP binding loops; other site 1124983010566 ABC-ATPase subunit interface; other site 1124983010567 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1124983010568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983010569 Walker A/P-loop; other site 1124983010570 ATP binding site [chemical binding]; other site 1124983010571 Q-loop/lid; other site 1124983010572 ABC transporter signature motif; other site 1124983010573 Walker B; other site 1124983010574 D-loop; other site 1124983010575 H-loop/switch region; other site 1124983010576 TOBE domain; Region: TOBE; pfam03459 1124983010577 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1124983010578 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1124983010579 active site 1124983010580 DNA binding site [nucleotide binding] 1124983010581 Int/Topo IB signature motif; other site 1124983010582 catalytic residues [active] 1124983010583 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1124983010584 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983010585 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983010586 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124983010587 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 1124983010588 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1124983010589 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1124983010590 Alginate lyase; Region: Alginate_lyase2; pfam08787 1124983010591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983010592 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983010593 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1124983010594 AAA domain; Region: AAA_33; pfam13671 1124983010595 AAA domain; Region: AAA_17; pfam13207 1124983010596 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1124983010597 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983010598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983010599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983010600 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1124983010601 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1124983010602 Predicted transcriptional regulators [Transcription]; Region: COG1733 1124983010603 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1124983010604 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1124983010605 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1124983010606 dimer interface [polypeptide binding]; other site 1124983010607 active site 1124983010608 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1124983010609 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1124983010610 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1124983010611 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1124983010612 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983010613 catalytic residue [active] 1124983010614 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 1124983010615 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1124983010616 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1124983010617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983010618 S-adenosylmethionine binding site [chemical binding]; other site 1124983010619 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1124983010620 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1124983010621 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983010622 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983010623 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1124983010624 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124983010625 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124983010626 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1124983010627 putative active site [active] 1124983010628 catalytic triad [active] 1124983010629 putative dimer interface [polypeptide binding]; other site 1124983010630 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1124983010631 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1124983010632 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983010633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983010634 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983010635 dimerization interface [polypeptide binding]; other site 1124983010636 Phage-related protein, tail component [Function unknown]; Region: COG4733 1124983010637 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1124983010638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124983010639 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124983010640 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983010641 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983010642 hypothetical protein; Provisional; Region: PRK07036 1124983010643 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983010644 inhibitor-cofactor binding pocket; inhibition site 1124983010645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983010646 catalytic residue [active] 1124983010647 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983010648 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983010649 DNA binding residues [nucleotide binding] 1124983010650 dimerization interface [polypeptide binding]; other site 1124983010651 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1124983010652 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124983010653 Membrane transport protein; Region: Mem_trans; cl09117 1124983010654 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 1124983010655 active site 1124983010656 catalytic residues [active] 1124983010657 metal binding site [ion binding]; metal-binding site 1124983010658 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1124983010659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983010660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983010661 homodimer interface [polypeptide binding]; other site 1124983010662 catalytic residue [active] 1124983010663 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1124983010664 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1124983010665 iron-sulfur cluster [ion binding]; other site 1124983010666 [2Fe-2S] cluster binding site [ion binding]; other site 1124983010667 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1124983010668 alpha subunit interface [polypeptide binding]; other site 1124983010669 active site 1124983010670 substrate binding site [chemical binding]; other site 1124983010671 Fe binding site [ion binding]; other site 1124983010672 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1124983010673 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1124983010674 FMN-binding pocket [chemical binding]; other site 1124983010675 flavin binding motif; other site 1124983010676 phosphate binding motif [ion binding]; other site 1124983010677 beta-alpha-beta structure motif; other site 1124983010678 NAD binding pocket [chemical binding]; other site 1124983010679 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983010680 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1124983010681 catalytic loop [active] 1124983010682 iron binding site [ion binding]; other site 1124983010683 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124983010684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983010685 DNA-binding site [nucleotide binding]; DNA binding site 1124983010686 FCD domain; Region: FCD; pfam07729 1124983010687 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983010688 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1124983010689 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983010690 NAD(P) binding site [chemical binding]; other site 1124983010691 catalytic residues [active] 1124983010692 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1124983010693 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1124983010694 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1124983010695 benzoate transport; Region: 2A0115; TIGR00895 1124983010696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010697 putative substrate translocation pore; other site 1124983010698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010699 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1124983010700 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124983010701 PYR/PP interface [polypeptide binding]; other site 1124983010702 dimer interface [polypeptide binding]; other site 1124983010703 TPP binding site [chemical binding]; other site 1124983010704 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124983010705 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1124983010706 TPP-binding site [chemical binding]; other site 1124983010707 dimer interface [polypeptide binding]; other site 1124983010708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983010709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983010710 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1124983010711 substrate binding pocket [chemical binding]; other site 1124983010712 dimerization interface [polypeptide binding]; other site 1124983010713 benzoate transport; Region: 2A0115; TIGR00895 1124983010714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010715 putative substrate translocation pore; other site 1124983010716 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1124983010717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983010718 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983010719 active site 1124983010720 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983010721 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1124983010722 dimer interface [polypeptide binding]; other site 1124983010723 active site 1124983010724 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1124983010725 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1124983010726 acyl-activating enzyme (AAE) consensus motif; other site 1124983010727 putative AMP binding site [chemical binding]; other site 1124983010728 putative active site [active] 1124983010729 putative CoA binding site [chemical binding]; other site 1124983010730 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983010731 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1124983010732 NAD(P) binding site [chemical binding]; other site 1124983010733 catalytic residues [active] 1124983010734 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 1124983010735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983010736 substrate binding site [chemical binding]; other site 1124983010737 oxyanion hole (OAH) forming residues; other site 1124983010738 trimer interface [polypeptide binding]; other site 1124983010739 MarR family; Region: MarR_2; pfam12802 1124983010740 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983010741 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1124983010742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010743 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1124983010744 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1124983010745 putative NAD(P) binding site [chemical binding]; other site 1124983010746 MarR family; Region: MarR_2; pfam12802 1124983010747 RNA polymerase sigma factor; Provisional; Region: PRK12528 1124983010748 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983010749 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983010750 DNA binding residues [nucleotide binding] 1124983010751 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983010752 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983010753 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1124983010754 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983010755 N-terminal plug; other site 1124983010756 ligand-binding site [chemical binding]; other site 1124983010757 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983010758 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1124983010759 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 1124983010760 isochorismate synthases; Region: isochor_syn; TIGR00543 1124983010761 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1124983010762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983010763 NAD(P) binding site [chemical binding]; other site 1124983010764 Condensation domain; Region: Condensation; pfam00668 1124983010765 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1124983010766 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1124983010767 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983010768 acyl-activating enzyme (AAE) consensus motif; other site 1124983010769 AMP binding site [chemical binding]; other site 1124983010770 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1124983010771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983010772 S-adenosylmethionine binding site [chemical binding]; other site 1124983010773 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983010774 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983010775 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1124983010776 Condensation domain; Region: Condensation; pfam00668 1124983010777 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983010778 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1124983010779 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1124983010780 acyl-activating enzyme (AAE) consensus motif; other site 1124983010781 AMP binding site [chemical binding]; other site 1124983010782 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983010783 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1124983010784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983010785 Walker A/P-loop; other site 1124983010786 ATP binding site [chemical binding]; other site 1124983010787 Q-loop/lid; other site 1124983010788 ABC transporter signature motif; other site 1124983010789 Walker B; other site 1124983010790 D-loop; other site 1124983010791 H-loop/switch region; other site 1124983010792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983010793 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1124983010794 Walker A/P-loop; other site 1124983010795 ATP binding site [chemical binding]; other site 1124983010796 Q-loop/lid; other site 1124983010797 ABC transporter signature motif; other site 1124983010798 Walker B; other site 1124983010799 D-loop; other site 1124983010800 H-loop/switch region; other site 1124983010801 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1124983010802 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1124983010803 acyl-activating enzyme (AAE) consensus motif; other site 1124983010804 active site 1124983010805 AMP binding site [chemical binding]; other site 1124983010806 substrate binding site [chemical binding]; other site 1124983010807 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983010808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983010809 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1124983010810 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983010811 N-terminal plug; other site 1124983010812 ligand-binding site [chemical binding]; other site 1124983010813 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1124983010814 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1124983010815 putative ligand binding residues [chemical binding]; other site 1124983010816 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1124983010817 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124983010818 putative PBP binding regions; other site 1124983010819 ABC-ATPase subunit interface; other site 1124983010820 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1124983010821 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1124983010822 Walker A/P-loop; other site 1124983010823 ATP binding site [chemical binding]; other site 1124983010824 Q-loop/lid; other site 1124983010825 ABC transporter signature motif; other site 1124983010826 Walker B; other site 1124983010827 D-loop; other site 1124983010828 H-loop/switch region; other site 1124983010829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010830 putative substrate translocation pore; other site 1124983010831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983010832 putative arabinose transporter; Provisional; Region: PRK03545 1124983010833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010834 putative substrate translocation pore; other site 1124983010835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983010836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983010837 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983010838 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1124983010839 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1124983010840 Metal-binding active site; metal-binding site 1124983010841 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1124983010842 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1124983010843 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1124983010844 active site 1124983010845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983010846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983010847 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983010848 putative effector binding pocket; other site 1124983010849 dimerization interface [polypeptide binding]; other site 1124983010850 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1124983010851 methionine synthase; Provisional; Region: PRK01207 1124983010852 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1124983010853 substrate binding site [chemical binding]; other site 1124983010854 THF binding site; other site 1124983010855 zinc-binding site [ion binding]; other site 1124983010856 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1124983010857 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983010858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983010859 putative DNA binding site [nucleotide binding]; other site 1124983010860 putative Zn2+ binding site [ion binding]; other site 1124983010861 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983010862 methionine gamma-lyase; Provisional; Region: PRK07503 1124983010863 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1124983010864 homodimer interface [polypeptide binding]; other site 1124983010865 substrate-cofactor binding pocket; other site 1124983010866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983010867 catalytic residue [active] 1124983010868 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1124983010869 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1124983010870 dimerization interface [polypeptide binding]; other site 1124983010871 ligand binding site [chemical binding]; other site 1124983010872 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1124983010873 Phage Tail Collar Domain; Region: Collar; pfam07484 1124983010874 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1124983010875 Phage Tail Collar Domain; Region: Collar; pfam07484 1124983010876 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1124983010877 Phage Tail Collar Domain; Region: Collar; pfam07484 1124983010878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983010879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983010880 Coenzyme A binding pocket [chemical binding]; other site 1124983010881 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1124983010882 Putative Ig domain; Region: He_PIG; pfam05345 1124983010883 Putative Ig domain; Region: He_PIG; pfam05345 1124983010884 Putative Ig domain; Region: He_PIG; pfam05345 1124983010885 Autotransporter beta-domain; Region: Autotransporter; smart00869 1124983010886 putative aminotransferase; Provisional; Region: PRK12403 1124983010887 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983010888 inhibitor-cofactor binding pocket; inhibition site 1124983010889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983010890 catalytic residue [active] 1124983010891 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1124983010892 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983010893 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1124983010894 NAD(P) binding site [chemical binding]; other site 1124983010895 catalytic residues [active] 1124983010896 acetylornithine deacetylase; Provisional; Region: PRK07522 1124983010897 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1124983010898 metal binding site [ion binding]; metal-binding site 1124983010899 putative dimer interface [polypeptide binding]; other site 1124983010900 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1124983010901 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1124983010902 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1124983010903 homotrimer interaction site [polypeptide binding]; other site 1124983010904 putative active site [active] 1124983010905 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1124983010906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983010907 AMP-binding domain protein; Validated; Region: PRK07529 1124983010908 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983010909 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1124983010910 acyl-activating enzyme (AAE) consensus motif; other site 1124983010911 putative AMP binding site [chemical binding]; other site 1124983010912 putative active site [active] 1124983010913 putative CoA binding site [chemical binding]; other site 1124983010914 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983010915 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983010916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983010917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983010918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983010919 dimerization interface [polypeptide binding]; other site 1124983010920 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1124983010921 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1124983010922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983010923 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983010924 putative substrate translocation pore; other site 1124983010925 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1124983010926 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1124983010927 metal binding site [ion binding]; metal-binding site 1124983010928 putative dimer interface [polypeptide binding]; other site 1124983010929 putative amidase; Provisional; Region: PRK06169 1124983010930 Amidase; Region: Amidase; cl11426 1124983010931 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983010932 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1124983010933 putative active site [active] 1124983010934 heme pocket [chemical binding]; other site 1124983010935 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1124983010936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983010937 putative active site [active] 1124983010938 heme pocket [chemical binding]; other site 1124983010939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983010940 dimer interface [polypeptide binding]; other site 1124983010941 phosphorylation site [posttranslational modification] 1124983010942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983010943 ATP binding site [chemical binding]; other site 1124983010944 Mg2+ binding site [ion binding]; other site 1124983010945 G-X-G motif; other site 1124983010946 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983010947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983010948 active site 1124983010949 phosphorylation site [posttranslational modification] 1124983010950 intermolecular recognition site; other site 1124983010951 dimerization interface [polypeptide binding]; other site 1124983010952 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1124983010953 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1124983010954 dimer interface [polypeptide binding]; other site 1124983010955 active site 1124983010956 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983010957 catalytic residues [active] 1124983010958 substrate binding site [chemical binding]; other site 1124983010959 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1124983010960 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1124983010961 NAD(P) binding pocket [chemical binding]; other site 1124983010962 hypothetical protein; Provisional; Region: PRK06156 1124983010963 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1124983010964 active site 1124983010965 metal binding site [ion binding]; metal-binding site 1124983010966 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1124983010967 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1124983010968 putative di-iron ligands [ion binding]; other site 1124983010969 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1124983010970 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1124983010971 active site 1124983010972 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1124983010973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1124983010974 active site 1124983010975 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1124983010976 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983010977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983010978 substrate binding pocket [chemical binding]; other site 1124983010979 membrane-bound complex binding site; other site 1124983010980 hinge residues; other site 1124983010981 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983010982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983010983 dimer interface [polypeptide binding]; other site 1124983010984 conserved gate region; other site 1124983010985 putative PBP binding loops; other site 1124983010986 ABC-ATPase subunit interface; other site 1124983010987 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983010988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983010989 dimer interface [polypeptide binding]; other site 1124983010990 conserved gate region; other site 1124983010991 putative PBP binding loops; other site 1124983010992 ABC-ATPase subunit interface; other site 1124983010993 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983010994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983010995 Walker A/P-loop; other site 1124983010996 ATP binding site [chemical binding]; other site 1124983010997 Q-loop/lid; other site 1124983010998 ABC transporter signature motif; other site 1124983010999 Walker B; other site 1124983011000 D-loop; other site 1124983011001 H-loop/switch region; other site 1124983011002 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1124983011003 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1124983011004 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1124983011005 active site 1124983011006 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1124983011007 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1124983011008 putative active site [active] 1124983011009 putative FMN binding site [chemical binding]; other site 1124983011010 putative substrate binding site [chemical binding]; other site 1124983011011 putative catalytic residue [active] 1124983011012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983011013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983011014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983011015 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1124983011016 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1124983011017 active site 1124983011018 benzoate transport; Region: 2A0115; TIGR00895 1124983011019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983011020 putative substrate translocation pore; other site 1124983011021 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124983011022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983011023 DNA-binding site [nucleotide binding]; DNA binding site 1124983011024 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124983011025 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1124983011026 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1124983011027 active site 1124983011028 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1124983011029 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983011030 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1124983011031 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983011032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011033 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983011034 dimerization interface [polypeptide binding]; other site 1124983011035 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1124983011036 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1124983011037 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1124983011038 GIY-YIG motif/motif A; other site 1124983011039 active site 1124983011040 catalytic site [active] 1124983011041 putative DNA binding site [nucleotide binding]; other site 1124983011042 metal binding site [ion binding]; metal-binding site 1124983011043 UvrB/uvrC motif; Region: UVR; pfam02151 1124983011044 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1124983011045 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1124983011046 DNA binding site [nucleotide binding] 1124983011047 response regulator; Provisional; Region: PRK09483 1124983011048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011049 active site 1124983011050 phosphorylation site [posttranslational modification] 1124983011051 intermolecular recognition site; other site 1124983011052 dimerization interface [polypeptide binding]; other site 1124983011053 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983011054 DNA binding residues [nucleotide binding] 1124983011055 dimerization interface [polypeptide binding]; other site 1124983011056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983011057 non-specific DNA binding site [nucleotide binding]; other site 1124983011058 salt bridge; other site 1124983011059 sequence-specific DNA binding site [nucleotide binding]; other site 1124983011060 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1124983011061 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983011062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983011063 Coenzyme A binding pocket [chemical binding]; other site 1124983011064 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124983011065 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1124983011066 active site 1124983011067 catalytic triad [active] 1124983011068 dimer interface [polypeptide binding]; other site 1124983011069 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1124983011070 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1124983011071 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1124983011072 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1124983011073 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1124983011074 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1124983011075 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1124983011076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983011077 dimer interface [polypeptide binding]; other site 1124983011078 conserved gate region; other site 1124983011079 putative PBP binding loops; other site 1124983011080 ABC-ATPase subunit interface; other site 1124983011081 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1124983011082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983011083 dimer interface [polypeptide binding]; other site 1124983011084 conserved gate region; other site 1124983011085 putative PBP binding loops; other site 1124983011086 ABC-ATPase subunit interface; other site 1124983011087 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1124983011088 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983011089 Walker A/P-loop; other site 1124983011090 ATP binding site [chemical binding]; other site 1124983011091 Q-loop/lid; other site 1124983011092 ABC transporter signature motif; other site 1124983011093 Walker B; other site 1124983011094 D-loop; other site 1124983011095 H-loop/switch region; other site 1124983011096 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983011097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983011098 Walker A/P-loop; other site 1124983011099 ATP binding site [chemical binding]; other site 1124983011100 Q-loop/lid; other site 1124983011101 ABC transporter signature motif; other site 1124983011102 Walker B; other site 1124983011103 D-loop; other site 1124983011104 H-loop/switch region; other site 1124983011105 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983011106 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1124983011107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983011108 Walker A motif; other site 1124983011109 ATP binding site [chemical binding]; other site 1124983011110 Walker B motif; other site 1124983011111 arginine finger; other site 1124983011112 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983011113 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1124983011114 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1124983011115 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1124983011116 NAD binding site [chemical binding]; other site 1124983011117 homotetramer interface [polypeptide binding]; other site 1124983011118 homodimer interface [polypeptide binding]; other site 1124983011119 substrate binding site [chemical binding]; other site 1124983011120 active site 1124983011121 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1124983011122 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1124983011123 acyl-activating enzyme (AAE) consensus motif; other site 1124983011124 putative AMP binding site [chemical binding]; other site 1124983011125 putative active site [active] 1124983011126 putative CoA binding site [chemical binding]; other site 1124983011127 PAS fold; Region: PAS_4; pfam08448 1124983011128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983011129 putative active site [active] 1124983011130 heme pocket [chemical binding]; other site 1124983011131 PAS fold; Region: PAS_4; pfam08448 1124983011132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983011133 putative active site [active] 1124983011134 heme pocket [chemical binding]; other site 1124983011135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983011136 dimer interface [polypeptide binding]; other site 1124983011137 phosphorylation site [posttranslational modification] 1124983011138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983011139 ATP binding site [chemical binding]; other site 1124983011140 Mg2+ binding site [ion binding]; other site 1124983011141 G-X-G motif; other site 1124983011142 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983011143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011144 active site 1124983011145 phosphorylation site [posttranslational modification] 1124983011146 intermolecular recognition site; other site 1124983011147 dimerization interface [polypeptide binding]; other site 1124983011148 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1124983011149 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1124983011150 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1124983011151 substrate binding site [chemical binding]; other site 1124983011152 ATP binding site [chemical binding]; other site 1124983011153 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1124983011154 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1124983011155 dimer interface [polypeptide binding]; other site 1124983011156 active site 1124983011157 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983011158 substrate binding site [chemical binding]; other site 1124983011159 catalytic residue [active] 1124983011160 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124983011161 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1124983011162 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124983011163 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1124983011164 homotrimer interaction site [polypeptide binding]; other site 1124983011165 putative active site [active] 1124983011166 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1124983011167 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1124983011168 conserved cys residue [active] 1124983011169 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1124983011170 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983011171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983011172 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983011173 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983011174 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983011175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983011177 dimerization interface [polypeptide binding]; other site 1124983011178 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1124983011179 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1124983011180 active site 1124983011181 homodimer interface [polypeptide binding]; other site 1124983011182 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983011183 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983011184 metal binding site [ion binding]; metal-binding site 1124983011185 active site 1124983011186 I-site; other site 1124983011187 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1124983011188 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1124983011189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124983011190 Transporter associated domain; Region: CorC_HlyC; smart01091 1124983011191 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1124983011192 dimer interface [polypeptide binding]; other site 1124983011193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124983011194 metal binding site [ion binding]; metal-binding site 1124983011195 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1124983011196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011197 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1124983011198 dimerization interface [polypeptide binding]; other site 1124983011199 substrate binding pocket [chemical binding]; other site 1124983011200 Domain of unknown function (DUF336); Region: DUF336; cl01249 1124983011201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983011202 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1124983011203 putative substrate translocation pore; other site 1124983011204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983011205 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983011206 pyruvate dehydrogenase; Provisional; Region: PRK09124 1124983011207 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1124983011208 PYR/PP interface [polypeptide binding]; other site 1124983011209 dimer interface [polypeptide binding]; other site 1124983011210 tetramer interface [polypeptide binding]; other site 1124983011211 TPP binding site [chemical binding]; other site 1124983011212 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124983011213 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1124983011214 TPP-binding site [chemical binding]; other site 1124983011215 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1124983011216 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 1124983011217 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1124983011218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983011219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983011220 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 1124983011221 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1124983011222 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1124983011223 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1124983011224 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1124983011225 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1124983011226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983011227 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1124983011228 DNA binding residues [nucleotide binding] 1124983011229 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983011230 FecR protein; Region: FecR; pfam04773 1124983011231 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983011232 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1124983011233 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1124983011234 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1124983011235 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1124983011236 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1124983011237 active site 1124983011238 phosphorylation site [posttranslational modification] 1124983011239 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983011240 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983011241 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983011242 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983011243 multidrug efflux protein; Reviewed; Region: PRK09579 1124983011244 Protein export membrane protein; Region: SecD_SecF; cl14618 1124983011245 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1124983011246 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1124983011247 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1124983011248 active site 1124983011249 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1124983011250 non-prolyl cis peptide bond; other site 1124983011251 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1124983011252 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983011253 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124983011254 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124983011255 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124983011256 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124983011257 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1124983011258 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1124983011259 Walker A/P-loop; other site 1124983011260 ATP binding site [chemical binding]; other site 1124983011261 Q-loop/lid; other site 1124983011262 ABC transporter signature motif; other site 1124983011263 Walker B; other site 1124983011264 D-loop; other site 1124983011265 H-loop/switch region; other site 1124983011266 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1124983011267 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1124983011268 siderophore binding site; other site 1124983011269 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1124983011270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124983011271 dimer interface [polypeptide binding]; other site 1124983011272 putative PBP binding regions; other site 1124983011273 ABC-ATPase subunit interface; other site 1124983011274 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124983011275 ABC-ATPase subunit interface; other site 1124983011276 dimer interface [polypeptide binding]; other site 1124983011277 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1124983011278 transcriptional regulator TraR; Provisional; Region: PRK13870 1124983011279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983011280 DNA binding residues [nucleotide binding] 1124983011281 dimerization interface [polypeptide binding]; other site 1124983011282 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124983011283 Beta-lactamase; Region: Beta-lactamase; pfam00144 1124983011284 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1124983011285 RibD C-terminal domain; Region: RibD_C; cl17279 1124983011286 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1124983011287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983011288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983011290 dimerization interface [polypeptide binding]; other site 1124983011291 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 1124983011292 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983011293 putative NAD(P) binding site [chemical binding]; other site 1124983011294 putative active site [active] 1124983011295 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 1124983011296 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1124983011297 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1124983011298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983011299 dimer interface [polypeptide binding]; other site 1124983011300 phosphorylation site [posttranslational modification] 1124983011301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983011302 ATP binding site [chemical binding]; other site 1124983011303 Mg2+ binding site [ion binding]; other site 1124983011304 G-X-G motif; other site 1124983011305 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983011306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011307 active site 1124983011308 phosphorylation site [posttranslational modification] 1124983011309 intermolecular recognition site; other site 1124983011310 dimerization interface [polypeptide binding]; other site 1124983011311 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983011312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011313 active site 1124983011314 phosphorylation site [posttranslational modification] 1124983011315 intermolecular recognition site; other site 1124983011316 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983011317 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1124983011318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983011319 dimer interface [polypeptide binding]; other site 1124983011320 phosphorylation site [posttranslational modification] 1124983011321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983011322 ATP binding site [chemical binding]; other site 1124983011323 Mg2+ binding site [ion binding]; other site 1124983011324 G-X-G motif; other site 1124983011325 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983011326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011327 active site 1124983011328 phosphorylation site [posttranslational modification] 1124983011329 intermolecular recognition site; other site 1124983011330 dimerization interface [polypeptide binding]; other site 1124983011331 Hpt domain; Region: Hpt; pfam01627 1124983011332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983011333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011334 active site 1124983011335 phosphorylation site [posttranslational modification] 1124983011336 intermolecular recognition site; other site 1124983011337 dimerization interface [polypeptide binding]; other site 1124983011338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983011339 DNA binding residues [nucleotide binding] 1124983011340 dimerization interface [polypeptide binding]; other site 1124983011341 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1124983011342 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983011343 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983011344 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1124983011345 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1124983011346 active site 1124983011347 Zn binding site [ion binding]; other site 1124983011348 ornithine cyclodeaminase; Validated; Region: PRK07589 1124983011349 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1124983011350 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1124983011351 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 1124983011352 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1124983011353 active site 1124983011354 Putative cyclase; Region: Cyclase; pfam04199 1124983011355 Putative cyclase; Region: Cyclase; cl00814 1124983011356 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 1124983011357 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1124983011358 putative NAD(P) binding site [chemical binding]; other site 1124983011359 active site 1124983011360 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983011361 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1124983011362 NAD(P) binding site [chemical binding]; other site 1124983011363 catalytic residues [active] 1124983011364 catalytic residues [active] 1124983011365 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1124983011366 tartrate dehydrogenase; Region: TTC; TIGR02089 1124983011367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983011368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011369 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1124983011370 putative dimerization interface [polypeptide binding]; other site 1124983011371 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 1124983011372 PLD-like domain; Region: PLDc_2; pfam13091 1124983011373 putative active site [active] 1124983011374 catalytic site [active] 1124983011375 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1124983011376 PLD-like domain; Region: PLDc_2; pfam13091 1124983011377 putative active site [active] 1124983011378 catalytic site [active] 1124983011379 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1124983011380 metal ion-dependent adhesion site (MIDAS); other site 1124983011381 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1124983011382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983011383 Walker A motif; other site 1124983011384 ATP binding site [chemical binding]; other site 1124983011385 Walker B motif; other site 1124983011386 arginine finger; other site 1124983011387 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1124983011388 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1124983011389 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1124983011390 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1124983011391 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1124983011392 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1124983011393 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 1124983011394 Predicted integral membrane protein [Function unknown]; Region: COG5446 1124983011395 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1124983011396 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1124983011397 active site 1124983011398 SAM binding site [chemical binding]; other site 1124983011399 homodimer interface [polypeptide binding]; other site 1124983011400 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1124983011401 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1124983011402 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1124983011403 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1124983011404 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1124983011405 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1124983011406 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1124983011407 substrate binding pocket [chemical binding]; other site 1124983011408 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1124983011409 B12 binding site [chemical binding]; other site 1124983011410 cobalt ligand [ion binding]; other site 1124983011411 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1124983011412 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1124983011413 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1124983011414 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 1124983011415 putative ligand binding site [chemical binding]; other site 1124983011416 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1124983011417 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124983011418 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1124983011419 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1124983011420 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1124983011421 putative inner membrane peptidase; Provisional; Region: PRK11778 1124983011422 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1124983011423 tandem repeat interface [polypeptide binding]; other site 1124983011424 oligomer interface [polypeptide binding]; other site 1124983011425 active site residues [active] 1124983011426 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124983011427 catalytic core [active] 1124983011428 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1124983011429 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 1124983011430 putative active site [active] 1124983011431 putative substrate binding site [chemical binding]; other site 1124983011432 putative cosubstrate binding site; other site 1124983011433 catalytic site [active] 1124983011434 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 1124983011435 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983011436 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1124983011437 substrate binding site [chemical binding]; other site 1124983011438 oxyanion hole (OAH) forming residues; other site 1124983011439 trimer interface [polypeptide binding]; other site 1124983011440 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1124983011441 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1124983011442 putative active site [active] 1124983011443 putative metal binding site [ion binding]; other site 1124983011444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983011445 AAA domain; Region: AAA_22; pfam13401 1124983011446 Walker A motif; other site 1124983011447 ATP binding site [chemical binding]; other site 1124983011448 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1124983011449 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124983011450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983011451 DNA-binding site [nucleotide binding]; DNA binding site 1124983011452 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124983011453 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1124983011454 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1124983011455 putative ligand binding site [chemical binding]; other site 1124983011456 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1124983011457 TM-ABC transporter signature motif; other site 1124983011458 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1124983011459 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1124983011460 TM-ABC transporter signature motif; other site 1124983011461 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1124983011462 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1124983011463 Walker A/P-loop; other site 1124983011464 ATP binding site [chemical binding]; other site 1124983011465 Q-loop/lid; other site 1124983011466 ABC transporter signature motif; other site 1124983011467 Walker B; other site 1124983011468 D-loop; other site 1124983011469 H-loop/switch region; other site 1124983011470 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1124983011471 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1124983011472 Walker A/P-loop; other site 1124983011473 ATP binding site [chemical binding]; other site 1124983011474 Q-loop/lid; other site 1124983011475 ABC transporter signature motif; other site 1124983011476 Walker B; other site 1124983011477 D-loop; other site 1124983011478 H-loop/switch region; other site 1124983011479 allantoate amidohydrolase; Reviewed; Region: PRK12893 1124983011480 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1124983011481 active site 1124983011482 metal binding site [ion binding]; metal-binding site 1124983011483 dimer interface [polypeptide binding]; other site 1124983011484 putative amidase; Provisional; Region: PRK06169 1124983011485 Amidase; Region: Amidase; pfam01425 1124983011486 amidase; Provisional; Region: PRK07042 1124983011487 Amidase; Region: Amidase; cl11426 1124983011488 citrate-proton symporter; Provisional; Region: PRK15075 1124983011489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983011490 putative substrate translocation pore; other site 1124983011491 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983011492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983011493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983011495 dimerization interface [polypeptide binding]; other site 1124983011496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983011497 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1124983011498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011499 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1124983011500 substrate binding pocket [chemical binding]; other site 1124983011501 dimerization interface [polypeptide binding]; other site 1124983011502 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1124983011503 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1124983011504 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983011505 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1124983011506 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1124983011507 hydrophobic ligand binding site; other site 1124983011508 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1124983011509 Strictosidine synthase; Region: Str_synth; pfam03088 1124983011510 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1124983011511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983011512 Walker A/P-loop; other site 1124983011513 ATP binding site [chemical binding]; other site 1124983011514 Q-loop/lid; other site 1124983011515 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1124983011516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983011517 Walker A/P-loop; other site 1124983011518 ATP binding site [chemical binding]; other site 1124983011519 Q-loop/lid; other site 1124983011520 ABC transporter signature motif; other site 1124983011521 Walker B; other site 1124983011522 D-loop; other site 1124983011523 H-loop/switch region; other site 1124983011524 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1124983011525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983011526 PAS fold; Region: PAS_3; pfam08447 1124983011527 putative active site [active] 1124983011528 heme pocket [chemical binding]; other site 1124983011529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983011530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983011531 dimer interface [polypeptide binding]; other site 1124983011532 phosphorylation site [posttranslational modification] 1124983011533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983011534 ATP binding site [chemical binding]; other site 1124983011535 Mg2+ binding site [ion binding]; other site 1124983011536 G-X-G motif; other site 1124983011537 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983011538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011539 active site 1124983011540 phosphorylation site [posttranslational modification] 1124983011541 intermolecular recognition site; other site 1124983011542 dimerization interface [polypeptide binding]; other site 1124983011543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 1124983011544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1124983011545 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 1124983011546 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1124983011547 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1124983011548 putative active site [active] 1124983011549 putative PHP Thumb interface [polypeptide binding]; other site 1124983011550 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1124983011551 generic binding surface I; other site 1124983011552 generic binding surface II; other site 1124983011553 DNA Polymerase Y-family; Region: PolY_like; cd03468 1124983011554 active site 1124983011555 DNA binding site [nucleotide binding] 1124983011556 LexA repressor; Provisional; Region: PRK12423 1124983011557 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1124983011558 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124983011559 Catalytic site [active] 1124983011560 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983011561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011562 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983011563 putative effector binding pocket; other site 1124983011564 dimerization interface [polypeptide binding]; other site 1124983011565 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1124983011566 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1124983011567 active site 1124983011568 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1124983011569 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1124983011570 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124983011571 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1124983011572 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 1124983011573 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983011574 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983011575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983011576 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1124983011577 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1124983011578 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 1124983011579 dimer interface [polypeptide binding]; other site 1124983011580 active site 1124983011581 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983011582 substrate binding site [chemical binding]; other site 1124983011583 catalytic residue [active] 1124983011584 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1124983011585 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983011586 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1124983011587 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1124983011588 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1124983011589 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1124983011590 TolR protein; Region: tolR; TIGR02801 1124983011591 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1124983011592 Phytase; Region: Phytase; cl17685 1124983011593 Phytase; Region: Phytase; cl17685 1124983011594 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1124983011595 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124983011596 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983011597 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983011598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983011599 metal binding site [ion binding]; metal-binding site 1124983011600 active site 1124983011601 I-site; other site 1124983011602 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983011603 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983011604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983011605 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1124983011606 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983011607 tetrameric interface [polypeptide binding]; other site 1124983011608 activator binding site; other site 1124983011609 NADP binding site [chemical binding]; other site 1124983011610 substrate binding site [chemical binding]; other site 1124983011611 catalytic residues [active] 1124983011612 Predicted membrane protein [Function unknown]; Region: COG1289 1124983011613 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124983011614 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1124983011615 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1124983011616 dimer interface [polypeptide binding]; other site 1124983011617 putative functional site; other site 1124983011618 putative MPT binding site; other site 1124983011619 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1124983011620 MPT binding site; other site 1124983011621 trimer interface [polypeptide binding]; other site 1124983011622 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1124983011623 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1124983011624 GTP binding site; other site 1124983011625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983011626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983011628 dimerization interface [polypeptide binding]; other site 1124983011629 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 1124983011630 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1124983011631 MoaE homodimer interface [polypeptide binding]; other site 1124983011632 MoaD interaction [polypeptide binding]; other site 1124983011633 active site residues [active] 1124983011634 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1124983011635 MoaE interaction surface [polypeptide binding]; other site 1124983011636 MoeB interaction surface [polypeptide binding]; other site 1124983011637 thiocarboxylated glycine; other site 1124983011638 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1124983011639 trimer interface [polypeptide binding]; other site 1124983011640 dimer interface [polypeptide binding]; other site 1124983011641 putative active site [active] 1124983011642 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1124983011643 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1124983011644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983011645 FeS/SAM binding site; other site 1124983011646 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1124983011647 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1124983011648 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1124983011649 putative molybdopterin cofactor binding site [chemical binding]; other site 1124983011650 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1124983011651 putative molybdopterin cofactor binding site; other site 1124983011652 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1124983011653 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1124983011654 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1124983011655 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1124983011656 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1124983011657 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1124983011658 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1124983011659 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1124983011660 putative molybdopterin cofactor binding site [chemical binding]; other site 1124983011661 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1124983011662 putative molybdopterin cofactor binding site; other site 1124983011663 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124983011664 EamA-like transporter family; Region: EamA; pfam00892 1124983011665 EamA-like transporter family; Region: EamA; pfam00892 1124983011666 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983011667 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1124983011668 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983011669 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1124983011670 YccA-like proteins; Region: YccA_like; cd10433 1124983011671 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1124983011672 Predicted chitinase [General function prediction only]; Region: COG3179 1124983011673 Phage-related protein, tail component [Function unknown]; Region: COG4733 1124983011674 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1124983011675 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1124983011676 Phage-related protein, tail component [Function unknown]; Region: COG4723 1124983011677 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1124983011678 MPN+ (JAMM) motif; other site 1124983011679 Zinc-binding site [ion binding]; other site 1124983011680 NlpC/P60 family; Region: NLPC_P60; cl17555 1124983011681 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1124983011682 Phage-related protein [Function unknown]; Region: gp18; COG4672 1124983011683 Bacteriophage T4 gp9/10-like protein; Region: T4_gp9_10; cl17844 1124983011684 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1124983011685 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1124983011686 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1124983011687 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1124983011688 KilA-N domain; Region: KilA-N; pfam04383 1124983011689 Prophage antirepressor [Transcription]; Region: COG3617 1124983011690 BRO family, N-terminal domain; Region: Bro-N; smart01040 1124983011691 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 1124983011692 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 1124983011693 Phage tail protein; Region: Phage_tail_3; pfam08813 1124983011694 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 1124983011695 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935 1124983011696 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1124983011697 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1124983011698 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 1124983011699 Phage terminase large subunit; Region: Terminase_3; cl12054 1124983011700 Terminase-like family; Region: Terminase_6; pfam03237 1124983011701 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 1124983011702 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1124983011703 Short C-terminal domain; Region: SHOCT; pfam09851 1124983011704 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1124983011705 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1124983011706 Replication protein P; Region: Phage_lambda_P; pfam06992 1124983011707 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1124983011708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1124983011709 non-specific DNA binding site [nucleotide binding]; other site 1124983011710 salt bridge; other site 1124983011711 sequence-specific DNA binding site [nucleotide binding]; other site 1124983011712 Predicted transcriptional regulator [Transcription]; Region: COG2932 1124983011713 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124983011714 Catalytic site [active] 1124983011715 ParB-like nuclease domain; Region: ParBc; cl02129 1124983011716 KorB domain; Region: KorB; pfam08535 1124983011717 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1124983011718 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1124983011719 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1124983011720 substrate interaction site [chemical binding]; other site 1124983011721 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1124983011722 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 1124983011723 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1124983011724 Ligand Binding Site [chemical binding]; other site 1124983011725 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 1124983011726 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124983011727 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124983011728 active site 1124983011729 DNA binding site [nucleotide binding] 1124983011730 Int/Topo IB signature motif; other site 1124983011731 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1124983011732 Predicted chitinase [General function prediction only]; Region: COG3179 1124983011733 catalytic residue [active] 1124983011734 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1124983011735 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983011736 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1124983011737 virion protein; Provisional; Region: V; PHA02564 1124983011738 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1124983011739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983011740 Zn2+ binding site [ion binding]; other site 1124983011741 Mg2+ binding site [ion binding]; other site 1124983011742 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1124983011743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983011744 Coenzyme A binding pocket [chemical binding]; other site 1124983011745 hypothetical protein; Provisional; Region: PRK11171 1124983011746 Cupin domain; Region: Cupin_2; pfam07883 1124983011747 Cupin domain; Region: Cupin_2; pfam07883 1124983011748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983011749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983011751 dimerization interface [polypeptide binding]; other site 1124983011752 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1124983011753 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1124983011754 Repair protein; Region: Repair_PSII; pfam04536 1124983011755 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983011756 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1124983011757 NAD(P) binding site [chemical binding]; other site 1124983011758 catalytic residues [active] 1124983011759 homoserine dehydrogenase; Provisional; Region: PRK06270 1124983011760 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1124983011761 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1124983011762 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983011763 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1124983011764 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983011765 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1124983011766 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1124983011767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983011768 catalytic residue [active] 1124983011769 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983011770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011771 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983011772 dimerization interface [polypeptide binding]; other site 1124983011773 substrate binding pocket [chemical binding]; other site 1124983011774 S-methylmethionine transporter; Provisional; Region: PRK11387 1124983011775 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1124983011776 cystathionine gamma-synthase; Provisional; Region: PRK08249 1124983011777 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1124983011778 homodimer interface [polypeptide binding]; other site 1124983011779 substrate-cofactor binding pocket; other site 1124983011780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983011781 catalytic residue [active] 1124983011782 DinB family; Region: DinB; cl17821 1124983011783 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1124983011784 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1124983011785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983011786 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983011787 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983011788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983011789 SnoaL-like domain; Region: SnoaL_3; pfam13474 1124983011790 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1124983011791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1124983011792 Histidine kinase; Region: HisKA_3; pfam07730 1124983011793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983011794 ATP binding site [chemical binding]; other site 1124983011795 Mg2+ binding site [ion binding]; other site 1124983011796 G-X-G motif; other site 1124983011797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983011798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011799 active site 1124983011800 phosphorylation site [posttranslational modification] 1124983011801 intermolecular recognition site; other site 1124983011802 dimerization interface [polypeptide binding]; other site 1124983011803 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983011804 DNA binding residues [nucleotide binding] 1124983011805 dimerization interface [polypeptide binding]; other site 1124983011806 CHASE3 domain; Region: CHASE3; pfam05227 1124983011807 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1124983011808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983011809 putative active site [active] 1124983011810 heme pocket [chemical binding]; other site 1124983011811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983011812 dimer interface [polypeptide binding]; other site 1124983011813 phosphorylation site [posttranslational modification] 1124983011814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983011815 ATP binding site [chemical binding]; other site 1124983011816 Mg2+ binding site [ion binding]; other site 1124983011817 G-X-G motif; other site 1124983011818 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983011819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011820 active site 1124983011821 phosphorylation site [posttranslational modification] 1124983011822 intermolecular recognition site; other site 1124983011823 dimerization interface [polypeptide binding]; other site 1124983011824 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983011825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011826 active site 1124983011827 phosphorylation site [posttranslational modification] 1124983011828 intermolecular recognition site; other site 1124983011829 dimerization interface [polypeptide binding]; other site 1124983011830 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983011831 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983011832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983011833 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1124983011834 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1124983011835 CAAX protease self-immunity; Region: Abi; pfam02517 1124983011836 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983011837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983011838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011839 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1124983011840 putative dimerization interface [polypeptide binding]; other site 1124983011841 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1124983011842 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1124983011843 NAD(P) binding site [chemical binding]; other site 1124983011844 catalytic residues [active] 1124983011845 Arc-like DNA binding domain; Region: Arc; pfam03869 1124983011846 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983011847 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983011848 N-terminal plug; other site 1124983011849 ligand-binding site [chemical binding]; other site 1124983011850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983011851 salt bridge; other site 1124983011852 non-specific DNA binding site [nucleotide binding]; other site 1124983011853 sequence-specific DNA binding site [nucleotide binding]; other site 1124983011854 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1124983011855 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1124983011856 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1124983011857 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1124983011858 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1124983011859 homodimer interface [polypeptide binding]; other site 1124983011860 chemical substrate binding site [chemical binding]; other site 1124983011861 oligomer interface [polypeptide binding]; other site 1124983011862 metal binding site [ion binding]; metal-binding site 1124983011863 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1124983011864 Part of AAA domain; Region: AAA_19; pfam13245 1124983011865 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1124983011866 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1124983011867 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1124983011868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1124983011869 active site 1124983011870 Sulfatase; Region: Sulfatase; cl17466 1124983011871 classical (c) SDRs; Region: SDR_c; cd05233 1124983011872 NAD(P) binding site [chemical binding]; other site 1124983011873 active site 1124983011874 HNH endonuclease; Region: HNH; pfam01844 1124983011875 active site 1124983011876 Sulfatase; Region: Sulfatase; pfam00884 1124983011877 BNR repeat-like domain; Region: BNR_2; pfam13088 1124983011878 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1124983011879 Asp-box motif; other site 1124983011880 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1124983011881 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1124983011882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983011883 active site 1124983011884 phosphorylation site [posttranslational modification] 1124983011885 intermolecular recognition site; other site 1124983011886 dimerization interface [polypeptide binding]; other site 1124983011887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983011888 DNA binding site [nucleotide binding] 1124983011889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983011890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983011891 dimer interface [polypeptide binding]; other site 1124983011892 phosphorylation site [posttranslational modification] 1124983011893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983011894 ATP binding site [chemical binding]; other site 1124983011895 Mg2+ binding site [ion binding]; other site 1124983011896 G-X-G motif; other site 1124983011897 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1124983011898 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1124983011899 putative NAD(P) binding site [chemical binding]; other site 1124983011900 active site 1124983011901 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1124983011902 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983011903 catalytic loop [active] 1124983011904 iron binding site [ion binding]; other site 1124983011905 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1124983011906 FAD binding pocket [chemical binding]; other site 1124983011907 FAD binding motif [chemical binding]; other site 1124983011908 phosphate binding motif [ion binding]; other site 1124983011909 beta-alpha-beta structure motif; other site 1124983011910 NAD binding pocket [chemical binding]; other site 1124983011911 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1124983011912 inter-subunit interface; other site 1124983011913 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1124983011914 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1124983011915 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1124983011916 putative alpha subunit interface [polypeptide binding]; other site 1124983011917 putative active site [active] 1124983011918 putative substrate binding site [chemical binding]; other site 1124983011919 Fe binding site [ion binding]; other site 1124983011920 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983011921 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983011922 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1124983011923 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1124983011924 dimer interface [polypeptide binding]; other site 1124983011925 active site 1124983011926 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1124983011927 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1124983011928 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1124983011929 octamer interface [polypeptide binding]; other site 1124983011930 active site 1124983011931 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1124983011932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983011933 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1124983011934 dimerizarion interface [polypeptide binding]; other site 1124983011935 CrgA pocket; other site 1124983011936 substrate binding pocket [chemical binding]; other site 1124983011937 RDD family; Region: RDD; pfam06271 1124983011938 Predicted membrane protein [Function unknown]; Region: COG3619 1124983011939 classical (c) SDRs; Region: SDR_c; cd05233 1124983011940 NAD(P) binding site [chemical binding]; other site 1124983011941 active site 1124983011942 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1124983011943 sulfur relay protein TusC; Validated; Region: PRK00211 1124983011944 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 1124983011945 DsrC like protein; Region: DsrC; cl01101 1124983011946 hypothetical protein; Validated; Region: PRK09071 1124983011947 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1124983011948 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1124983011949 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1124983011950 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1124983011951 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1124983011952 putative dimer interface [polypeptide binding]; other site 1124983011953 N-terminal domain interface [polypeptide binding]; other site 1124983011954 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983011955 siroheme synthase; Provisional; Region: cysG; PRK10637 1124983011956 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1124983011957 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1124983011958 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1124983011959 active site 1124983011960 SAM binding site [chemical binding]; other site 1124983011961 homodimer interface [polypeptide binding]; other site 1124983011962 seryl-tRNA synthetase; Provisional; Region: PRK05431 1124983011963 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1124983011964 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1124983011965 dimer interface [polypeptide binding]; other site 1124983011966 active site 1124983011967 motif 1; other site 1124983011968 motif 2; other site 1124983011969 motif 3; other site 1124983011970 camphor resistance protein CrcB; Provisional; Region: PRK14234 1124983011971 recombination factor protein RarA; Reviewed; Region: PRK13342 1124983011972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983011973 Walker A motif; other site 1124983011974 ATP binding site [chemical binding]; other site 1124983011975 Walker B motif; other site 1124983011976 arginine finger; other site 1124983011977 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1124983011978 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1124983011979 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1124983011980 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1124983011981 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1124983011982 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1124983011983 thioredoxin reductase; Provisional; Region: PRK10262 1124983011984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983011985 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1124983011986 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1124983011987 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1124983011988 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1124983011989 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1124983011990 rRNA binding site [nucleotide binding]; other site 1124983011991 predicted 30S ribosome binding site; other site 1124983011992 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1124983011993 Clp amino terminal domain; Region: Clp_N; pfam02861 1124983011994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983011995 Walker A motif; other site 1124983011996 ATP binding site [chemical binding]; other site 1124983011997 Walker B motif; other site 1124983011998 arginine finger; other site 1124983011999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983012000 Walker A motif; other site 1124983012001 ATP binding site [chemical binding]; other site 1124983012002 Walker B motif; other site 1124983012003 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1124983012004 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1124983012005 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124983012006 DNA-binding site [nucleotide binding]; DNA binding site 1124983012007 RNA-binding motif; other site 1124983012008 isocitrate dehydrogenase; Validated; Region: PRK07362 1124983012009 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1124983012010 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1124983012011 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1124983012012 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1124983012013 nudix motif; other site 1124983012014 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1124983012015 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1124983012016 putative lysogenization regulator; Reviewed; Region: PRK00218 1124983012017 adenylosuccinate lyase; Provisional; Region: PRK09285 1124983012018 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1124983012019 tetramer interface [polypeptide binding]; other site 1124983012020 active site 1124983012021 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1124983012022 Cupin-like domain; Region: Cupin_8; pfam13621 1124983012023 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983012024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983012025 Coenzyme A binding pocket [chemical binding]; other site 1124983012026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983012027 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1124983012028 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1124983012029 isocitrate lyase; Provisional; Region: PRK15063 1124983012030 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1124983012031 tetramer interface [polypeptide binding]; other site 1124983012032 active site 1124983012033 Mg2+/Mn2+ binding site [ion binding]; other site 1124983012034 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1124983012035 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1124983012036 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1124983012037 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1124983012038 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1124983012039 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1124983012040 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1124983012041 putative dimer interface [polypeptide binding]; other site 1124983012042 [2Fe-2S] cluster binding site [ion binding]; other site 1124983012043 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1124983012044 SLBB domain; Region: SLBB; pfam10531 1124983012045 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1124983012046 NADH dehydrogenase subunit G; Validated; Region: PRK08166 1124983012047 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983012048 catalytic loop [active] 1124983012049 iron binding site [ion binding]; other site 1124983012050 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1124983012051 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1124983012052 [4Fe-4S] binding site [ion binding]; other site 1124983012053 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1124983012054 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1124983012055 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1124983012056 4Fe-4S binding domain; Region: Fer4; pfam00037 1124983012057 4Fe-4S binding domain; Region: Fer4; pfam00037 1124983012058 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1124983012059 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1124983012060 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1124983012061 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1124983012062 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1124983012063 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124983012064 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1124983012065 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124983012066 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1124983012067 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1124983012068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1124983012069 salt bridge; other site 1124983012070 non-specific DNA binding site [nucleotide binding]; other site 1124983012071 sequence-specific DNA binding site [nucleotide binding]; other site 1124983012072 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1124983012073 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1124983012074 active site 1124983012075 HIGH motif; other site 1124983012076 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1124983012077 KMSKS motif; other site 1124983012078 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1124983012079 tRNA binding surface [nucleotide binding]; other site 1124983012080 anticodon binding site; other site 1124983012081 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1124983012082 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1124983012083 active site 1124983012084 HIGH motif; other site 1124983012085 nucleotide binding site [chemical binding]; other site 1124983012086 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1124983012087 KMSKS motif; other site 1124983012088 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1124983012089 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1124983012090 substrate binding site [chemical binding]; other site 1124983012091 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1124983012092 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1124983012093 putative active site [active] 1124983012094 putative metal binding site [ion binding]; other site 1124983012095 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1124983012096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012097 putative substrate translocation pore; other site 1124983012098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012099 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1124983012100 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983012101 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983012102 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983012103 MarR family; Region: MarR_2; cl17246 1124983012104 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124983012105 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1124983012106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983012107 dimer interface [polypeptide binding]; other site 1124983012108 phosphorylation site [posttranslational modification] 1124983012109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983012110 ATP binding site [chemical binding]; other site 1124983012111 Mg2+ binding site [ion binding]; other site 1124983012112 G-X-G motif; other site 1124983012113 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983012114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983012115 active site 1124983012116 phosphorylation site [posttranslational modification] 1124983012117 intermolecular recognition site; other site 1124983012118 dimerization interface [polypeptide binding]; other site 1124983012119 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1124983012120 putative binding surface; other site 1124983012121 active site 1124983012122 transcriptional regulator RcsB; Provisional; Region: PRK10840 1124983012123 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1124983012124 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1124983012125 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124983012126 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1124983012127 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1124983012128 PapC N-terminal domain; Region: PapC_N; pfam13954 1124983012129 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124983012130 PapC C-terminal domain; Region: PapC_C; pfam13953 1124983012131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1124983012132 Family of unknown function (DUF490); Region: DUF490; pfam04357 1124983012133 Family of unknown function (DUF490); Region: DUF490; pfam04357 1124983012134 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1124983012135 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124983012136 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1124983012137 Surface antigen; Region: Bac_surface_Ag; pfam01103 1124983012138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1124983012139 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1124983012140 putative catalytic site [active] 1124983012141 putative phosphate binding site [ion binding]; other site 1124983012142 active site 1124983012143 metal binding site A [ion binding]; metal-binding site 1124983012144 DNA binding site [nucleotide binding] 1124983012145 putative AP binding site [nucleotide binding]; other site 1124983012146 putative metal binding site B [ion binding]; other site 1124983012147 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1124983012148 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1124983012149 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983012150 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983012151 ligand binding site [chemical binding]; other site 1124983012152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983012153 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1124983012154 FAD binding site [chemical binding]; other site 1124983012155 substrate binding site [chemical binding]; other site 1124983012156 catalytic base [active] 1124983012157 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1124983012158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983012159 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1124983012160 substrate binding pocket [chemical binding]; other site 1124983012161 dimerization interface [polypeptide binding]; other site 1124983012162 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1124983012163 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1124983012164 DNA binding residues [nucleotide binding] 1124983012165 putative dimer interface [polypeptide binding]; other site 1124983012166 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1124983012167 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1124983012168 active site 1124983012169 catalytic residues [active] 1124983012170 metal binding site [ion binding]; metal-binding site 1124983012171 AMP-binding domain protein; Validated; Region: PRK08315 1124983012172 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983012173 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1124983012174 acyl-activating enzyme (AAE) consensus motif; other site 1124983012175 putative AMP binding site [chemical binding]; other site 1124983012176 putative active site [active] 1124983012177 putative CoA binding site [chemical binding]; other site 1124983012178 isovaleryl-CoA dehydrogenase; Region: PLN02519 1124983012179 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1124983012180 substrate binding site [chemical binding]; other site 1124983012181 FAD binding site [chemical binding]; other site 1124983012182 catalytic base [active] 1124983012183 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1124983012184 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1124983012185 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1124983012186 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1124983012187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983012188 substrate binding site [chemical binding]; other site 1124983012189 oxyanion hole (OAH) forming residues; other site 1124983012190 trimer interface [polypeptide binding]; other site 1124983012191 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1124983012192 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124983012193 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1124983012194 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1124983012195 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124983012196 carboxyltransferase (CT) interaction site; other site 1124983012197 biotinylation site [posttranslational modification]; other site 1124983012198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983012199 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983012200 non-specific DNA binding site [nucleotide binding]; other site 1124983012201 salt bridge; other site 1124983012202 sequence-specific DNA binding site [nucleotide binding]; other site 1124983012203 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124983012204 Catalytic site [active] 1124983012205 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1124983012206 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1124983012207 active site 1124983012208 Zn binding site [ion binding]; other site 1124983012209 Predicted transcriptional regulators [Transcription]; Region: COG1733 1124983012210 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1124983012211 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1124983012212 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1124983012213 putative heme binding pocket [chemical binding]; other site 1124983012214 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1124983012215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983012216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983012217 DNA binding residues [nucleotide binding] 1124983012218 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1124983012219 Spore Coat Protein U domain; Region: SCPU; pfam05229 1124983012220 Spore Coat Protein U domain; Region: SCPU; pfam05229 1124983012221 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1124983012222 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1124983012223 PapC C-terminal domain; Region: PapC_C; pfam13953 1124983012224 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1124983012225 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1124983012226 Spore Coat Protein U domain; Region: SCPU; pfam05229 1124983012227 Spore Coat Protein U domain; Region: SCPU; pfam05229 1124983012228 Spore Coat Protein U domain; Region: SCPU; pfam05229 1124983012229 Spore Coat Protein U domain; Region: SCPU; pfam05229 1124983012230 Predicted ATPase [General function prediction only]; Region: COG1485 1124983012231 Leucine rich repeat; Region: LRR_8; pfam13855 1124983012232 Leucine rich repeat; Region: LRR_8; pfam13855 1124983012233 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1124983012234 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1124983012235 active site 1124983012236 ATP binding site [chemical binding]; other site 1124983012237 substrate binding site [chemical binding]; other site 1124983012238 activation loop (A-loop); other site 1124983012239 hypothetical protein; Provisional; Region: PRK12378 1124983012240 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983012241 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983012242 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1124983012243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012244 putative substrate translocation pore; other site 1124983012245 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1124983012246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983012247 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983012248 dimerization interface [polypeptide binding]; other site 1124983012249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983012250 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1124983012251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983012252 dimerization interface [polypeptide binding]; other site 1124983012253 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1124983012254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983012255 catalytic residue [active] 1124983012256 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1124983012257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983012258 motif II; other site 1124983012259 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1124983012260 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1124983012261 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1124983012262 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1124983012263 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1124983012264 active site 1124983012265 FMN binding site [chemical binding]; other site 1124983012266 2,4-decadienoyl-CoA binding site; other site 1124983012267 catalytic residue [active] 1124983012268 4Fe-4S cluster binding site [ion binding]; other site 1124983012269 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1124983012270 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983012271 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124983012272 Beta-lactamase; Region: Beta-lactamase; pfam00144 1124983012273 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1124983012274 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1124983012275 putative di-iron ligands [ion binding]; other site 1124983012276 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1124983012277 active site 1124983012278 catalytic triad [active] 1124983012279 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124983012280 dimer interface [polypeptide binding]; other site 1124983012281 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983012282 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983012283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983012284 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1124983012285 MarR family; Region: MarR_2; cl17246 1124983012286 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124983012287 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1124983012288 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1124983012289 dimer interface [polypeptide binding]; other site 1124983012290 TPP-binding site [chemical binding]; other site 1124983012291 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 1124983012292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983012293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983012294 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1124983012295 putative effector binding pocket; other site 1124983012296 putative dimerization interface [polypeptide binding]; other site 1124983012297 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124983012298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012299 putative substrate translocation pore; other site 1124983012300 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1124983012301 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1124983012302 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983012303 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1124983012304 periplasmic folding chaperone; Provisional; Region: PRK10788 1124983012305 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1124983012306 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1124983012307 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124983012308 IHF - DNA interface [nucleotide binding]; other site 1124983012309 IHF dimer interface [polypeptide binding]; other site 1124983012310 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1124983012311 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1124983012312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983012313 Walker A motif; other site 1124983012314 ATP binding site [chemical binding]; other site 1124983012315 Walker B motif; other site 1124983012316 arginine finger; other site 1124983012317 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1124983012318 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1124983012319 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1124983012320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983012321 Walker A motif; other site 1124983012322 ATP binding site [chemical binding]; other site 1124983012323 Walker B motif; other site 1124983012324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1124983012325 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1124983012326 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1124983012327 oligomer interface [polypeptide binding]; other site 1124983012328 active site residues [active] 1124983012329 trigger factor; Provisional; Region: tig; PRK01490 1124983012330 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124983012331 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1124983012332 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1124983012333 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1124983012334 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1124983012335 homodimer interface [polypeptide binding]; other site 1124983012336 NADP binding site [chemical binding]; other site 1124983012337 substrate binding site [chemical binding]; other site 1124983012338 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1124983012339 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1124983012340 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1124983012341 putative active site [active] 1124983012342 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1124983012343 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1124983012344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983012345 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1124983012346 putative dimerization interface [polypeptide binding]; other site 1124983012347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012348 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124983012349 putative substrate translocation pore; other site 1124983012350 serine/threonine transporter SstT; Provisional; Region: PRK13628 1124983012351 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124983012352 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1124983012353 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983012354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983012355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983012356 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1124983012357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1124983012358 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1124983012359 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1124983012360 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1124983012361 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1124983012362 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1124983012363 shikimate binding site; other site 1124983012364 NAD(P) binding site [chemical binding]; other site 1124983012365 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1124983012366 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1124983012367 putative protease; Provisional; Region: PRK15452 1124983012368 Peptidase family U32; Region: Peptidase_U32; pfam01136 1124983012369 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1124983012370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983012371 dimerization interface [polypeptide binding]; other site 1124983012372 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983012373 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983012374 dimer interface [polypeptide binding]; other site 1124983012375 putative CheW interface [polypeptide binding]; other site 1124983012376 Predicted permease [General function prediction only]; Region: COG2056 1124983012377 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1124983012378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983012379 dimerization interface [polypeptide binding]; other site 1124983012380 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983012381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983012382 dimer interface [polypeptide binding]; other site 1124983012383 putative CheW interface [polypeptide binding]; other site 1124983012384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983012385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983012386 ATP binding site [chemical binding]; other site 1124983012387 G-X-G motif; other site 1124983012388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983012389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983012390 active site 1124983012391 phosphorylation site [posttranslational modification] 1124983012392 intermolecular recognition site; other site 1124983012393 dimerization interface [polypeptide binding]; other site 1124983012394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983012395 DNA binding site [nucleotide binding] 1124983012396 Predicted membrane protein [Function unknown]; Region: COG3212 1124983012397 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1124983012398 Predicted membrane protein [Function unknown]; Region: COG3212 1124983012399 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1124983012400 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1124983012401 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1124983012402 active site 1124983012403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983012404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983012405 Coenzyme A binding pocket [chemical binding]; other site 1124983012406 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1124983012407 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1124983012408 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124983012409 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1124983012410 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1124983012411 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1124983012412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1124983012413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983012414 dimer interface [polypeptide binding]; other site 1124983012415 conserved gate region; other site 1124983012416 putative PBP binding loops; other site 1124983012417 ABC-ATPase subunit interface; other site 1124983012418 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1124983012419 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1124983012420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983012421 dimer interface [polypeptide binding]; other site 1124983012422 conserved gate region; other site 1124983012423 putative PBP binding loops; other site 1124983012424 ABC-ATPase subunit interface; other site 1124983012425 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1124983012426 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983012427 Walker A/P-loop; other site 1124983012428 ATP binding site [chemical binding]; other site 1124983012429 Q-loop/lid; other site 1124983012430 ABC transporter signature motif; other site 1124983012431 Walker B; other site 1124983012432 D-loop; other site 1124983012433 H-loop/switch region; other site 1124983012434 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1124983012435 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1124983012436 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983012437 Walker A/P-loop; other site 1124983012438 ATP binding site [chemical binding]; other site 1124983012439 Q-loop/lid; other site 1124983012440 ABC transporter signature motif; other site 1124983012441 Walker B; other site 1124983012442 D-loop; other site 1124983012443 H-loop/switch region; other site 1124983012444 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983012445 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1124983012446 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1124983012447 nudix motif; other site 1124983012448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983012449 non-specific DNA binding site [nucleotide binding]; other site 1124983012450 salt bridge; other site 1124983012451 sequence-specific DNA binding site [nucleotide binding]; other site 1124983012452 cytosine permease; Provisional; Region: codB; PRK11017 1124983012453 Na binding site [ion binding]; other site 1124983012454 cytosine deaminase; Provisional; Region: PRK09230 1124983012455 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1124983012456 active site 1124983012457 diaminopimelate epimerase; Region: PLN02536 1124983012458 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983012459 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1124983012460 putative DNA binding site [nucleotide binding]; other site 1124983012461 putative Zn2+ binding site [ion binding]; other site 1124983012462 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983012463 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983012464 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1124983012465 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983012466 N-terminal plug; other site 1124983012467 ligand-binding site [chemical binding]; other site 1124983012468 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983012469 FecR protein; Region: FecR; pfam04773 1124983012470 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1124983012471 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983012472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983012473 DNA binding residues [nucleotide binding] 1124983012474 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983012475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983012476 non-specific DNA binding site [nucleotide binding]; other site 1124983012477 salt bridge; other site 1124983012478 sequence-specific DNA binding site [nucleotide binding]; other site 1124983012479 putative acetyltransferase; Provisional; Region: PRK03624 1124983012480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983012481 Coenzyme A binding pocket [chemical binding]; other site 1124983012482 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983012483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983012484 RNA polymerase sigma factor; Reviewed; Region: PRK05602 1124983012485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983012486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983012487 Heavy-metal resistance; Region: Metal_resist; pfam13801 1124983012488 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983012489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983012490 The C-terminal substrate domain of LysR-type transcriptional regulator AmpR that involved in control of the expression of beta-lactamase gene ampC, contains the type 2 periplasmic binding fold; Region: PBP2_AmpR; cd08488 1124983012491 putative dimerization interface [polypeptide binding]; other site 1124983012492 putative substrate binding pocket [chemical binding]; other site 1124983012493 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1124983012494 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1124983012495 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1124983012496 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1124983012497 PAS fold; Region: PAS_4; pfam08448 1124983012498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983012499 putative active site [active] 1124983012500 heme pocket [chemical binding]; other site 1124983012501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983012502 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1124983012503 putative active site [active] 1124983012504 heme pocket [chemical binding]; other site 1124983012505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983012506 dimer interface [polypeptide binding]; other site 1124983012507 phosphorylation site [posttranslational modification] 1124983012508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983012509 ATP binding site [chemical binding]; other site 1124983012510 Mg2+ binding site [ion binding]; other site 1124983012511 G-X-G motif; other site 1124983012512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983012513 active site 1124983012514 phosphorylation site [posttranslational modification] 1124983012515 intermolecular recognition site; other site 1124983012516 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983012517 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1124983012518 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1124983012519 active site 1124983012520 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 1124983012521 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1124983012522 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1124983012523 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1124983012524 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983012525 N-terminal plug; other site 1124983012526 ligand-binding site [chemical binding]; other site 1124983012527 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1124983012528 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983012529 Putative glucoamylase; Region: Glycoamylase; pfam10091 1124983012530 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1124983012531 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1124983012532 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1124983012533 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1124983012534 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124983012535 ligand binding site [chemical binding]; other site 1124983012536 flexible hinge region; other site 1124983012537 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1124983012538 non-specific DNA interactions [nucleotide binding]; other site 1124983012539 DNA binding site [nucleotide binding] 1124983012540 sequence specific DNA binding site [nucleotide binding]; other site 1124983012541 putative cAMP binding site [chemical binding]; other site 1124983012542 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124983012543 Ligand Binding Site [chemical binding]; other site 1124983012544 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124983012545 Ligand Binding Site [chemical binding]; other site 1124983012546 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1124983012547 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1124983012548 tetramer interface [polypeptide binding]; other site 1124983012549 catalytic Zn binding site [ion binding]; other site 1124983012550 NADP binding site [chemical binding]; other site 1124983012551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012552 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983012553 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983012554 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124983012555 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1124983012556 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1124983012557 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124983012558 ligand binding site [chemical binding]; other site 1124983012559 flexible hinge region; other site 1124983012560 Isochorismatase family; Region: Isochorismatase; pfam00857 1124983012561 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1124983012562 catalytic triad [active] 1124983012563 dimer interface [polypeptide binding]; other site 1124983012564 conserved cis-peptide bond; other site 1124983012565 Pirin-related protein [General function prediction only]; Region: COG1741 1124983012566 Pirin; Region: Pirin; pfam02678 1124983012567 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1124983012568 LysR family transcriptional regulator; Provisional; Region: PRK14997 1124983012569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983012570 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1124983012571 putative effector binding pocket; other site 1124983012572 putative dimerization interface [polypeptide binding]; other site 1124983012573 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124983012574 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124983012575 active site 1124983012576 catalytic tetrad [active] 1124983012577 response regulator PleD; Reviewed; Region: pleD; PRK09581 1124983012578 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1124983012579 MgtC family; Region: MgtC; pfam02308 1124983012580 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1124983012581 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1124983012582 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124983012583 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1124983012584 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1124983012585 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1124983012586 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1124983012587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983012588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983012589 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1124983012590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983012591 DNA binding residues [nucleotide binding] 1124983012592 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1124983012593 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124983012594 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983012595 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1124983012596 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124983012597 Walker A/P-loop; other site 1124983012598 ATP binding site [chemical binding]; other site 1124983012599 Q-loop/lid; other site 1124983012600 ABC transporter signature motif; other site 1124983012601 Walker B; other site 1124983012602 D-loop; other site 1124983012603 H-loop/switch region; other site 1124983012604 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124983012605 FtsX-like permease family; Region: FtsX; pfam02687 1124983012606 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1124983012607 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1124983012608 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1124983012609 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1124983012610 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1124983012611 active site 1124983012612 dimer interface [polypeptide binding]; other site 1124983012613 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1124983012614 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983012615 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983012616 catalytic residue [active] 1124983012617 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1124983012618 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1124983012619 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1124983012620 catalytic site [active] 1124983012621 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1124983012622 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983012623 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1124983012624 Walker A/P-loop; other site 1124983012625 ATP binding site [chemical binding]; other site 1124983012626 Q-loop/lid; other site 1124983012627 ABC transporter signature motif; other site 1124983012628 Walker B; other site 1124983012629 D-loop; other site 1124983012630 H-loop/switch region; other site 1124983012631 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983012632 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1124983012633 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983012634 N-terminal plug; other site 1124983012635 ligand-binding site [chemical binding]; other site 1124983012636 Condensation domain; Region: Condensation; pfam00668 1124983012637 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983012638 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983012639 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1124983012640 acyl-activating enzyme (AAE) consensus motif; other site 1124983012641 AMP binding site [chemical binding]; other site 1124983012642 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012643 Condensation domain; Region: Condensation; pfam00668 1124983012644 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1124983012645 Condensation domain; Region: Condensation; pfam00668 1124983012646 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983012647 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012648 acyl-activating enzyme (AAE) consensus motif; other site 1124983012649 AMP binding site [chemical binding]; other site 1124983012650 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012651 Condensation domain; Region: Condensation; pfam00668 1124983012652 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983012653 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1124983012654 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1124983012655 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012656 acyl-activating enzyme (AAE) consensus motif; other site 1124983012657 AMP binding site [chemical binding]; other site 1124983012658 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012659 Condensation domain; Region: Condensation; pfam00668 1124983012660 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983012661 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983012662 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012663 acyl-activating enzyme (AAE) consensus motif; other site 1124983012664 AMP binding site [chemical binding]; other site 1124983012665 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012666 Condensation domain; Region: Condensation; pfam00668 1124983012667 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1124983012668 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983012669 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1124983012670 acyl-activating enzyme (AAE) consensus motif; other site 1124983012671 AMP binding site [chemical binding]; other site 1124983012672 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012673 peptide synthase; Provisional; Region: PRK12467 1124983012674 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983012675 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012676 acyl-activating enzyme (AAE) consensus motif; other site 1124983012677 AMP binding site [chemical binding]; other site 1124983012678 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012679 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983012680 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012681 acyl-activating enzyme (AAE) consensus motif; other site 1124983012682 AMP binding site [chemical binding]; other site 1124983012683 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012684 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1124983012685 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012686 acyl-activating enzyme (AAE) consensus motif; other site 1124983012687 AMP binding site [chemical binding]; other site 1124983012688 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012689 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1124983012690 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1124983012691 FAD binding pocket [chemical binding]; other site 1124983012692 FAD binding motif [chemical binding]; other site 1124983012693 phosphate binding motif [ion binding]; other site 1124983012694 NAD binding pocket [chemical binding]; other site 1124983012695 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1124983012696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983012697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983012698 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1124983012699 NAD binding site [chemical binding]; other site 1124983012700 short chain dehydrogenase; Provisional; Region: PRK07577 1124983012701 homodimer interface [polypeptide binding]; other site 1124983012702 active site 1124983012703 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1124983012704 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1124983012705 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1124983012706 active site 1124983012707 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 1124983012708 catalytic triad [active] 1124983012709 conserved cis-peptide bond; other site 1124983012710 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983012711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983012712 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1124983012713 NAD(P) binding site [chemical binding]; other site 1124983012714 active site 1124983012715 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983012716 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1124983012717 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1124983012718 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1124983012719 conserved cys residue [active] 1124983012720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983012721 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1124983012722 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1124983012723 conserved cys residue [active] 1124983012724 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1124983012725 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983012726 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983012727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983012728 DNA-binding site [nucleotide binding]; DNA binding site 1124983012729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983012730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983012731 homodimer interface [polypeptide binding]; other site 1124983012732 catalytic residue [active] 1124983012733 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1124983012734 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1124983012735 putative hydrophobic ligand binding site [chemical binding]; other site 1124983012736 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1124983012737 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 1124983012738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1124983012739 quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907 1124983012740 Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992 1124983012741 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 1124983012742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983012743 FeS/SAM binding site; other site 1124983012744 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1124983012745 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 1124983012746 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1124983012747 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098 1124983012748 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 1124983012749 Domain of unknown function (DUF1928); Region: DUF1928; pfam09100 1124983012750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983012751 motif II; other site 1124983012752 2-isopropylmalate synthase; Validated; Region: PRK03739 1124983012753 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1124983012754 active site 1124983012755 catalytic residues [active] 1124983012756 metal binding site [ion binding]; metal-binding site 1124983012757 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1124983012758 Cupin domain; Region: Cupin_2; pfam07883 1124983012759 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983012760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983012761 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1124983012762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012763 putative substrate translocation pore; other site 1124983012764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012765 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983012766 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1124983012767 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983012768 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1124983012769 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 1124983012770 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1124983012771 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983012772 NAD(P) binding site [chemical binding]; other site 1124983012773 catalytic residues [active] 1124983012774 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1124983012775 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1124983012776 active site 1124983012777 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1124983012778 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1124983012779 active site 1124983012780 catalytic residues [active] 1124983012781 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1124983012782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983012783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983012784 Walker A/P-loop; other site 1124983012785 ATP binding site [chemical binding]; other site 1124983012786 Q-loop/lid; other site 1124983012787 ABC transporter signature motif; other site 1124983012788 Walker B; other site 1124983012789 D-loop; other site 1124983012790 H-loop/switch region; other site 1124983012791 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1124983012792 GAF domain; Region: GAF; pfam01590 1124983012793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983012794 Walker A motif; other site 1124983012795 ATP binding site [chemical binding]; other site 1124983012796 Walker B motif; other site 1124983012797 arginine finger; other site 1124983012798 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983012799 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1124983012800 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1124983012801 active site 1124983012802 Zn binding site [ion binding]; other site 1124983012803 allantoate amidohydrolase; Reviewed; Region: PRK12893 1124983012804 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1124983012805 active site 1124983012806 metal binding site [ion binding]; metal-binding site 1124983012807 dimer interface [polypeptide binding]; other site 1124983012808 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983012809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983012810 putative substrate translocation pore; other site 1124983012811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983012812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983012813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983012814 dimerization interface [polypeptide binding]; other site 1124983012815 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1124983012816 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1124983012817 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1124983012818 threonine and homoserine efflux system; Provisional; Region: PRK10532 1124983012819 EamA-like transporter family; Region: EamA; pfam00892 1124983012820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983012821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983012822 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1124983012823 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1124983012824 putative NAD(P) binding site [chemical binding]; other site 1124983012825 active site 1124983012826 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1124983012827 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1124983012828 putative catalytic residue [active] 1124983012829 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1124983012830 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1124983012831 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1124983012832 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1124983012833 active site 1124983012834 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983012835 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1124983012836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983012837 catalytic residue [active] 1124983012838 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983012839 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983012840 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 1124983012841 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1124983012842 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1124983012843 active site 1124983012844 dimer interface [polypeptide binding]; other site 1124983012845 non-prolyl cis peptide bond; other site 1124983012846 insertion regions; other site 1124983012847 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1124983012848 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1124983012849 Flavin binding site [chemical binding]; other site 1124983012850 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1124983012851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983012852 Walker A motif; other site 1124983012853 ATP binding site [chemical binding]; other site 1124983012854 Walker B motif; other site 1124983012855 arginine finger; other site 1124983012856 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1124983012857 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1124983012858 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1124983012859 DNA binding residues [nucleotide binding] 1124983012860 dimer interface [polypeptide binding]; other site 1124983012861 [2Fe-2S] cluster binding site [ion binding]; other site 1124983012862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983012863 Zeta toxin; Region: Zeta_toxin; pfam06414 1124983012864 Walker A motif; other site 1124983012865 ATP binding site [chemical binding]; other site 1124983012866 Walker B motif; other site 1124983012867 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1124983012868 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1124983012869 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983012870 FeS/SAM binding site; other site 1124983012871 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1124983012872 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1124983012873 active site 1124983012874 ATP binding site [chemical binding]; other site 1124983012875 substrate binding site [chemical binding]; other site 1124983012876 activation loop (A-loop); other site 1124983012877 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1124983012878 AAA domain; Region: AAA_11; pfam13086 1124983012879 Part of AAA domain; Region: AAA_19; pfam13245 1124983012880 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1124983012881 AAA domain; Region: AAA_12; pfam13087 1124983012882 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1124983012883 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1124983012884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983012885 ABC-ATPase subunit interface; other site 1124983012886 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1124983012887 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983012888 active site 1124983012889 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1124983012890 putative dimer interface [polypeptide binding]; other site 1124983012891 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1124983012892 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1124983012893 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1124983012894 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1124983012895 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1124983012896 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1124983012897 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1124983012898 metal binding site [ion binding]; metal-binding site 1124983012899 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1124983012900 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1124983012901 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1124983012902 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124983012903 ABC-ATPase subunit interface; other site 1124983012904 dimer interface [polypeptide binding]; other site 1124983012905 putative PBP binding regions; other site 1124983012906 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1124983012907 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1124983012908 intersubunit interface [polypeptide binding]; other site 1124983012909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983012910 S-adenosylmethionine binding site [chemical binding]; other site 1124983012911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1124983012912 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1124983012913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983012914 inhibitor-cofactor binding pocket; inhibition site 1124983012915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983012916 catalytic residue [active] 1124983012917 sensor protein QseC; Provisional; Region: PRK10337 1124983012918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983012919 dimer interface [polypeptide binding]; other site 1124983012920 phosphorylation site [posttranslational modification] 1124983012921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983012922 ATP binding site [chemical binding]; other site 1124983012923 G-X-G motif; other site 1124983012924 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1124983012925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983012926 active site 1124983012927 phosphorylation site [posttranslational modification] 1124983012928 intermolecular recognition site; other site 1124983012929 dimerization interface [polypeptide binding]; other site 1124983012930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983012931 DNA binding site [nucleotide binding] 1124983012932 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1124983012933 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1124983012934 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1124983012935 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1124983012936 DsbD alpha interface [polypeptide binding]; other site 1124983012937 catalytic residues [active] 1124983012938 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1124983012939 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1124983012940 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1124983012941 catalytic residues [active] 1124983012942 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1124983012943 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1124983012944 dimerization domain [polypeptide binding]; other site 1124983012945 dimer interface [polypeptide binding]; other site 1124983012946 catalytic residues [active] 1124983012947 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1124983012948 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1124983012949 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983012950 N-terminal plug; other site 1124983012951 ligand-binding site [chemical binding]; other site 1124983012952 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983012953 FecR protein; Region: FecR; pfam04773 1124983012954 RNA polymerase sigma factor; Provisional; Region: PRK12528 1124983012955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983012956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983012957 DNA binding residues [nucleotide binding] 1124983012958 peptide synthase; Validated; Region: PRK05691 1124983012959 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1124983012960 acyl-activating enzyme (AAE) consensus motif; other site 1124983012961 active site 1124983012962 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012963 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983012964 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012965 acyl-activating enzyme (AAE) consensus motif; other site 1124983012966 AMP binding site [chemical binding]; other site 1124983012967 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012968 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983012969 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012970 acyl-activating enzyme (AAE) consensus motif; other site 1124983012971 AMP binding site [chemical binding]; other site 1124983012972 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012973 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1124983012974 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1124983012975 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1124983012976 acyl-activating enzyme (AAE) consensus motif; other site 1124983012977 AMP binding site [chemical binding]; other site 1124983012978 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983012979 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1124983012980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983012981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983012982 DNA binding residues [nucleotide binding] 1124983012983 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1124983012984 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983012985 substrate binding pocket [chemical binding]; other site 1124983012986 membrane-bound complex binding site; other site 1124983012987 hinge residues; other site 1124983012988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983012989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983012990 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1124983012991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983012992 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1124983012993 NAD(P) binding site [chemical binding]; other site 1124983012994 active site 1124983012995 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1124983012996 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1124983012997 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1124983012998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983012999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983013000 active site 1124983013001 enoyl-CoA hydratase; Provisional; Region: PRK05995 1124983013002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983013003 substrate binding site [chemical binding]; other site 1124983013004 oxyanion hole (OAH) forming residues; other site 1124983013005 trimer interface [polypeptide binding]; other site 1124983013006 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1124983013007 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124983013008 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1124983013009 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1124983013010 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124983013011 carboxyltransferase (CT) interaction site; other site 1124983013012 biotinylation site [posttranslational modification]; other site 1124983013013 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1124983013014 active site 1124983013015 catalytic site [active] 1124983013016 substrate binding site [chemical binding]; other site 1124983013017 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1124983013018 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1124983013019 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1124983013020 MOSC domain; Region: MOSC; pfam03473 1124983013021 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1124983013022 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983013023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013024 active site 1124983013025 phosphorylation site [posttranslational modification] 1124983013026 intermolecular recognition site; other site 1124983013027 dimerization interface [polypeptide binding]; other site 1124983013028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1124983013029 Histidine kinase; Region: HisKA_3; pfam07730 1124983013030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013031 ATP binding site [chemical binding]; other site 1124983013032 Mg2+ binding site [ion binding]; other site 1124983013033 G-X-G motif; other site 1124983013034 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983013035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013036 active site 1124983013037 phosphorylation site [posttranslational modification] 1124983013038 intermolecular recognition site; other site 1124983013039 dimerization interface [polypeptide binding]; other site 1124983013040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983013041 DNA binding residues [nucleotide binding] 1124983013042 dimerization interface [polypeptide binding]; other site 1124983013043 lipid kinase; Reviewed; Region: PRK13054 1124983013044 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1124983013045 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1124983013046 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1124983013047 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1124983013048 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1124983013049 Substrate binding site; other site 1124983013050 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1124983013051 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1124983013052 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1124983013053 SLBB domain; Region: SLBB; pfam10531 1124983013054 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1124983013055 Chain length determinant protein; Region: Wzz; cl15801 1124983013056 Chain length determinant protein; Region: Wzz; cl15801 1124983013057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983013058 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1124983013059 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1124983013060 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1124983013061 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1124983013062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983013063 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1124983013064 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1124983013065 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1124983013066 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1124983013067 trimer interface [polypeptide binding]; other site 1124983013068 active site 1124983013069 substrate binding site [chemical binding]; other site 1124983013070 CoA binding site [chemical binding]; other site 1124983013071 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1124983013072 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1124983013073 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1124983013074 active site 1124983013075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983013076 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1124983013077 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1124983013078 dimer interface [polypeptide binding]; other site 1124983013079 putative functional site; other site 1124983013080 putative MPT binding site; other site 1124983013081 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1124983013082 MPT binding site; other site 1124983013083 trimer interface [polypeptide binding]; other site 1124983013084 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1124983013085 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1124983013086 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1124983013087 probable active site [active] 1124983013088 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1124983013089 Catalytic site [active] 1124983013090 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1124983013091 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1124983013092 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1124983013093 putative cation:proton antiport protein; Provisional; Region: PRK10669 1124983013094 TrkA-N domain; Region: TrkA_N; pfam02254 1124983013095 TrkA-C domain; Region: TrkA_C; pfam02080 1124983013096 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1124983013097 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1124983013098 Predicted membrane protein [Function unknown]; Region: COG5393 1124983013099 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983013100 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1124983013101 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1124983013102 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1124983013103 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1124983013104 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1124983013105 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1124983013106 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1124983013107 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1124983013108 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983013109 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983013110 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983013111 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983013112 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1124983013113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983013114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013115 active site 1124983013116 phosphorylation site [posttranslational modification] 1124983013117 intermolecular recognition site; other site 1124983013118 dimerization interface [polypeptide binding]; other site 1124983013119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983013120 DNA binding residues [nucleotide binding] 1124983013121 dimerization interface [polypeptide binding]; other site 1124983013122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983013123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983013124 dimer interface [polypeptide binding]; other site 1124983013125 phosphorylation site [posttranslational modification] 1124983013126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013127 ATP binding site [chemical binding]; other site 1124983013128 Mg2+ binding site [ion binding]; other site 1124983013129 G-X-G motif; other site 1124983013130 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983013131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013132 active site 1124983013133 phosphorylation site [posttranslational modification] 1124983013134 intermolecular recognition site; other site 1124983013135 dimerization interface [polypeptide binding]; other site 1124983013136 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983013137 putative binding surface; other site 1124983013138 active site 1124983013139 Cache domain; Region: Cache_1; pfam02743 1124983013140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1124983013141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983013142 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1124983013143 GAF domain; Region: GAF_2; pfam13185 1124983013144 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1124983013145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983013146 Walker A motif; other site 1124983013147 ATP binding site [chemical binding]; other site 1124983013148 Walker B motif; other site 1124983013149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983013150 dimer interface [polypeptide binding]; other site 1124983013151 phosphorylation site [posttranslational modification] 1124983013152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013153 ATP binding site [chemical binding]; other site 1124983013154 Mg2+ binding site [ion binding]; other site 1124983013155 G-X-G motif; other site 1124983013156 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983013157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013158 active site 1124983013159 phosphorylation site [posttranslational modification] 1124983013160 intermolecular recognition site; other site 1124983013161 dimerization interface [polypeptide binding]; other site 1124983013162 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1124983013163 MarR family; Region: MarR_2; cl17246 1124983013164 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1124983013165 catalytic residues [active] 1124983013166 dimer interface [polypeptide binding]; other site 1124983013167 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1124983013168 SelR domain; Region: SelR; pfam01641 1124983013169 aminotransferase AlaT; Validated; Region: PRK09265 1124983013170 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983013171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983013172 homodimer interface [polypeptide binding]; other site 1124983013173 catalytic residue [active] 1124983013174 heat shock protein HtpX; Provisional; Region: PRK05457 1124983013175 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 1124983013176 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1124983013177 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1124983013178 putative active site [active] 1124983013179 metal binding site [ion binding]; metal-binding site 1124983013180 helicase 45; Provisional; Region: PTZ00424 1124983013181 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124983013182 ATP binding site [chemical binding]; other site 1124983013183 Mg++ binding site [ion binding]; other site 1124983013184 motif III; other site 1124983013185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983013186 nucleotide binding region [chemical binding]; other site 1124983013187 ATP-binding site [chemical binding]; other site 1124983013188 DbpA RNA binding domain; Region: DbpA; pfam03880 1124983013189 enoyl-CoA hydratase; Provisional; Region: PRK06563 1124983013190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983013191 substrate binding site [chemical binding]; other site 1124983013192 oxyanion hole (OAH) forming residues; other site 1124983013193 trimer interface [polypeptide binding]; other site 1124983013194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983013195 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1124983013196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1124983013197 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1124983013198 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1124983013199 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1124983013200 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1124983013201 catalytic triad [active] 1124983013202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983013203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983013204 dimerization interface [polypeptide binding]; other site 1124983013205 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1124983013206 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983013207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983013208 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983013209 putative effector binding pocket; other site 1124983013210 dimerization interface [polypeptide binding]; other site 1124983013211 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124983013212 MarR family; Region: MarR; pfam01047 1124983013213 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1124983013214 elongation factor P; Validated; Region: PRK00529 1124983013215 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1124983013216 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1124983013217 RNA binding site [nucleotide binding]; other site 1124983013218 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1124983013219 RNA binding site [nucleotide binding]; other site 1124983013220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1124983013221 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1124983013222 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124983013223 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1124983013224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983013225 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1124983013226 substrate binding site [chemical binding]; other site 1124983013227 dimerization interface [polypeptide binding]; other site 1124983013228 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1124983013229 Ligand Binding Site [chemical binding]; other site 1124983013230 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1124983013231 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1124983013232 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1124983013233 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1124983013234 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1124983013235 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1124983013236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983013237 Coenzyme A binding pocket [chemical binding]; other site 1124983013238 L,D-transpeptidase; Provisional; Region: PRK10260 1124983013239 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1124983013240 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1124983013241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124983013242 Walker A/P-loop; other site 1124983013243 ATP binding site [chemical binding]; other site 1124983013244 Q-loop/lid; other site 1124983013245 ABC transporter signature motif; other site 1124983013246 Walker B; other site 1124983013247 D-loop; other site 1124983013248 H-loop/switch region; other site 1124983013249 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1124983013250 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1124983013251 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1124983013252 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1124983013253 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124983013254 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983013255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013256 active site 1124983013257 phosphorylation site [posttranslational modification] 1124983013258 intermolecular recognition site; other site 1124983013259 dimerization interface [polypeptide binding]; other site 1124983013260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983013261 DNA binding residues [nucleotide binding] 1124983013262 dimerization interface [polypeptide binding]; other site 1124983013263 Predicted membrane protein [Function unknown]; Region: COG2259 1124983013264 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 1124983013265 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124983013266 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124983013267 catalytic residue [active] 1124983013268 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1124983013269 active site 1124983013270 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983013271 dimerization interface [polypeptide binding]; other site 1124983013272 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983013273 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983013274 dimer interface [polypeptide binding]; other site 1124983013275 putative CheW interface [polypeptide binding]; other site 1124983013276 Terminase small subunit; Region: Terminase_2; cl01513 1124983013277 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1124983013278 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1124983013279 active site 1124983013280 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1124983013281 active site 2 [active] 1124983013282 active site 1 [active] 1124983013283 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1124983013284 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1124983013285 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1124983013286 active site 1124983013287 nucleophile elbow; other site 1124983013288 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1124983013289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013290 active site 1124983013291 phosphorylation site [posttranslational modification] 1124983013292 intermolecular recognition site; other site 1124983013293 dimerization interface [polypeptide binding]; other site 1124983013294 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983013295 DNA binding site [nucleotide binding] 1124983013296 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1124983013297 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1124983013298 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1124983013299 Ligand Binding Site [chemical binding]; other site 1124983013300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983013301 dimer interface [polypeptide binding]; other site 1124983013302 phosphorylation site [posttranslational modification] 1124983013303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013304 ATP binding site [chemical binding]; other site 1124983013305 Mg2+ binding site [ion binding]; other site 1124983013306 G-X-G motif; other site 1124983013307 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1124983013308 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1124983013309 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124983013310 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1124983013311 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1124983013312 ethanolamine permease; Region: 2A0305; TIGR00908 1124983013313 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1124983013314 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1124983013315 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124983013316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983013317 DNA-binding site [nucleotide binding]; DNA binding site 1124983013318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983013319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983013320 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1124983013321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983013322 NAD(P) binding site [chemical binding]; other site 1124983013323 active site 1124983013324 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1124983013325 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1124983013326 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1124983013327 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1124983013328 NAD(P) binding site [chemical binding]; other site 1124983013329 homodimer interface [polypeptide binding]; other site 1124983013330 substrate binding site [chemical binding]; other site 1124983013331 active site 1124983013332 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1124983013333 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1124983013334 Mg++ binding site [ion binding]; other site 1124983013335 putative catalytic motif [active] 1124983013336 putative substrate binding site [chemical binding]; other site 1124983013337 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983013338 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1124983013339 putative NAD(P) binding site [chemical binding]; other site 1124983013340 active site 1124983013341 putative substrate binding site [chemical binding]; other site 1124983013342 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1124983013343 putative ADP-binding pocket [chemical binding]; other site 1124983013344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1124983013345 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1124983013346 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1124983013347 active site 1124983013348 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1124983013349 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1124983013350 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1124983013351 inhibitor-cofactor binding pocket; inhibition site 1124983013352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983013353 catalytic residue [active] 1124983013354 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124983013355 IHF dimer interface [polypeptide binding]; other site 1124983013356 IHF - DNA interface [nucleotide binding]; other site 1124983013357 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1124983013358 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1124983013359 RNA binding site [nucleotide binding]; other site 1124983013360 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1124983013361 RNA binding site [nucleotide binding]; other site 1124983013362 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1124983013363 RNA binding site [nucleotide binding]; other site 1124983013364 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1124983013365 RNA binding site [nucleotide binding]; other site 1124983013366 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1124983013367 RNA binding site [nucleotide binding]; other site 1124983013368 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1124983013369 RNA binding site [nucleotide binding]; other site 1124983013370 cytidylate kinase; Provisional; Region: cmk; PRK00023 1124983013371 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1124983013372 CMP-binding site; other site 1124983013373 The sites determining sugar specificity; other site 1124983013374 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1124983013375 prephenate dehydrogenase; Validated; Region: PRK08507 1124983013376 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1124983013377 hinge; other site 1124983013378 active site 1124983013379 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1124983013380 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983013381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983013382 homodimer interface [polypeptide binding]; other site 1124983013383 catalytic residue [active] 1124983013384 Chorismate mutase type II; Region: CM_2; cl00693 1124983013385 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1124983013386 Prephenate dehydratase; Region: PDT; pfam00800 1124983013387 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1124983013388 putative L-Phe binding site [chemical binding]; other site 1124983013389 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1124983013390 homodimer interface [polypeptide binding]; other site 1124983013391 substrate-cofactor binding pocket; other site 1124983013392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983013393 catalytic residue [active] 1124983013394 DNA gyrase subunit A; Validated; Region: PRK05560 1124983013395 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1124983013396 CAP-like domain; other site 1124983013397 active site 1124983013398 primary dimer interface [polypeptide binding]; other site 1124983013399 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124983013400 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124983013401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124983013402 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124983013403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124983013404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1124983013405 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1124983013406 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1124983013407 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1124983013408 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1124983013409 active site 1124983013410 putative substrate binding pocket [chemical binding]; other site 1124983013411 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1124983013412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983013413 S-adenosylmethionine binding site [chemical binding]; other site 1124983013414 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1124983013415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1124983013416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983013417 motif II; other site 1124983013418 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1124983013419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983013420 NAD(P) binding site [chemical binding]; other site 1124983013421 active site 1124983013422 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983013423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983013424 metal binding site [ion binding]; metal-binding site 1124983013425 active site 1124983013426 I-site; other site 1124983013427 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 1124983013428 PAS domain S-box; Region: sensory_box; TIGR00229 1124983013429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983013430 putative active site [active] 1124983013431 heme pocket [chemical binding]; other site 1124983013432 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983013433 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983013434 metal binding site [ion binding]; metal-binding site 1124983013435 active site 1124983013436 I-site; other site 1124983013437 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983013438 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1124983013439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1124983013440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983013441 Walker A/P-loop; other site 1124983013442 ATP binding site [chemical binding]; other site 1124983013443 Q-loop/lid; other site 1124983013444 ABC transporter signature motif; other site 1124983013445 Walker B; other site 1124983013446 D-loop; other site 1124983013447 H-loop/switch region; other site 1124983013448 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1124983013449 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1124983013450 catalytic residues [active] 1124983013451 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1124983013452 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1124983013453 active site residue [active] 1124983013454 BolA-like protein; Region: BolA; pfam01722 1124983013455 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1124983013456 fumarate hydratase; Provisional; Region: PRK12425 1124983013457 Class II fumarases; Region: Fumarase_classII; cd01362 1124983013458 active site 1124983013459 tetramer interface [polypeptide binding]; other site 1124983013460 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983013461 EamA-like transporter family; Region: EamA; pfam00892 1124983013462 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1124983013463 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983013464 dimer interface [polypeptide binding]; other site 1124983013465 active site 1124983013466 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1124983013467 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1124983013468 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1124983013469 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1124983013470 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1124983013471 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1124983013472 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1124983013473 active site 1124983013474 dimer interface [polypeptide binding]; other site 1124983013475 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1124983013476 Ligand Binding Site [chemical binding]; other site 1124983013477 Molecular Tunnel; other site 1124983013478 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1124983013479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983013480 Coenzyme A binding pocket [chemical binding]; other site 1124983013481 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1124983013482 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1124983013483 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1124983013484 putative oligomer interface [polypeptide binding]; other site 1124983013485 putative active site [active] 1124983013486 metal binding site [ion binding]; metal-binding site 1124983013487 hypothetical protein; Provisional; Region: PRK00304 1124983013488 hypothetical protein; Provisional; Region: PRK02237 1124983013489 short chain dehydrogenase; Provisional; Region: PRK05650 1124983013490 classical (c) SDRs; Region: SDR_c; cd05233 1124983013491 NAD(P) binding site [chemical binding]; other site 1124983013492 active site 1124983013493 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1124983013494 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1124983013495 Sulfatase; Region: Sulfatase; pfam00884 1124983013496 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1124983013497 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1124983013498 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983013499 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1124983013500 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1124983013501 acyl-activating enzyme (AAE) consensus motif; other site 1124983013502 putative AMP binding site [chemical binding]; other site 1124983013503 putative active site [active] 1124983013504 putative CoA binding site [chemical binding]; other site 1124983013505 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1124983013506 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1124983013507 Cupin domain; Region: Cupin_2; pfam07883 1124983013508 MFS_1 like family; Region: MFS_1_like; pfam12832 1124983013509 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1124983013510 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1124983013511 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1124983013512 Tetramer interface [polypeptide binding]; other site 1124983013513 active site 1124983013514 FMN-binding site [chemical binding]; other site 1124983013515 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1124983013516 HemK family putative methylases; Region: hemK_fam; TIGR00536 1124983013517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983013518 S-adenosylmethionine binding site [chemical binding]; other site 1124983013519 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1124983013520 Isochorismatase family; Region: Isochorismatase; pfam00857 1124983013521 catalytic triad [active] 1124983013522 conserved cis-peptide bond; other site 1124983013523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1124983013524 Smr domain; Region: Smr; pfam01713 1124983013525 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1124983013526 homodecamer interface [polypeptide binding]; other site 1124983013527 GTP cyclohydrolase I; Provisional; Region: PLN03044 1124983013528 active site 1124983013529 putative catalytic site residues [active] 1124983013530 zinc binding site [ion binding]; other site 1124983013531 GTP-CH-I/GFRP interaction surface; other site 1124983013532 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1124983013533 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1124983013534 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1124983013535 Citrate transporter; Region: CitMHS; pfam03600 1124983013536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983013537 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1124983013538 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1124983013539 putative dimerization interface [polypeptide binding]; other site 1124983013540 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983013541 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1124983013542 putative C-terminal domain interface [polypeptide binding]; other site 1124983013543 putative GSH binding site (G-site) [chemical binding]; other site 1124983013544 putative dimer interface [polypeptide binding]; other site 1124983013545 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1124983013546 dimer interface [polypeptide binding]; other site 1124983013547 N-terminal domain interface [polypeptide binding]; other site 1124983013548 aspartate aminotransferase; Provisional; Region: PRK05764 1124983013549 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983013550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983013551 homodimer interface [polypeptide binding]; other site 1124983013552 catalytic residue [active] 1124983013553 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1124983013554 MarR family; Region: MarR_2; pfam12802 1124983013555 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1124983013556 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1124983013557 active site 1124983013558 homotetramer interface [polypeptide binding]; other site 1124983013559 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1124983013560 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1124983013561 active site 1124983013562 catalytic site [active] 1124983013563 tetramer interface [polypeptide binding]; other site 1124983013564 allantoicase; Provisional; Region: PRK13257 1124983013565 Allantoicase repeat; Region: Allantoicase; pfam03561 1124983013566 Allantoicase repeat; Region: Allantoicase; pfam03561 1124983013567 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1124983013568 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1124983013569 Predicted membrane protein [Function unknown]; Region: COG3748 1124983013570 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1124983013571 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983013572 xanthine permease; Region: pbuX; TIGR03173 1124983013573 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1124983013574 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124983013575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983013576 DNA-binding site [nucleotide binding]; DNA binding site 1124983013577 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124983013578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983013579 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1124983013580 putative substrate translocation pore; other site 1124983013581 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983013582 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1124983013583 putative NAD(P) binding site [chemical binding]; other site 1124983013584 active site 1124983013585 putative substrate binding site [chemical binding]; other site 1124983013586 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1124983013587 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1124983013588 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1124983013589 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1124983013590 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1124983013591 active site 1124983013592 nucleophile elbow; other site 1124983013593 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1124983013594 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1124983013595 putative acyl-acceptor binding pocket; other site 1124983013596 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1124983013597 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1124983013598 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1124983013599 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1124983013600 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1124983013601 Switch I; other site 1124983013602 Switch II; other site 1124983013603 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1124983013604 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1124983013605 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1124983013606 active site 1124983013607 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1124983013608 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1124983013609 active site 1124983013610 metal binding site [ion binding]; metal-binding site 1124983013611 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1124983013612 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124983013613 transcriptional regulator protein; Region: phnR; TIGR03337 1124983013614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983013615 DNA-binding site [nucleotide binding]; DNA binding site 1124983013616 UTRA domain; Region: UTRA; pfam07702 1124983013617 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124983013618 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1124983013619 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1124983013620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983013621 dimer interface [polypeptide binding]; other site 1124983013622 conserved gate region; other site 1124983013623 putative PBP binding loops; other site 1124983013624 ABC-ATPase subunit interface; other site 1124983013625 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124983013626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983013627 dimer interface [polypeptide binding]; other site 1124983013628 conserved gate region; other site 1124983013629 ABC-ATPase subunit interface; other site 1124983013630 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1124983013631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983013632 Walker A/P-loop; other site 1124983013633 ATP binding site [chemical binding]; other site 1124983013634 Q-loop/lid; other site 1124983013635 ABC transporter signature motif; other site 1124983013636 Walker B; other site 1124983013637 D-loop; other site 1124983013638 H-loop/switch region; other site 1124983013639 TOBE domain; Region: TOBE_2; pfam08402 1124983013640 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1124983013641 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1124983013642 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1124983013643 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1124983013644 NAD(P) binding site [chemical binding]; other site 1124983013645 carboxy-terminal protease; Provisional; Region: PRK11186 1124983013646 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1124983013647 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1124983013648 protein binding site [polypeptide binding]; other site 1124983013649 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1124983013650 Catalytic dyad [active] 1124983013651 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1124983013652 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983013653 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1124983013654 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983013655 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983013656 metal binding site [ion binding]; metal-binding site 1124983013657 active site 1124983013658 I-site; other site 1124983013659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983013660 non-specific DNA binding site [nucleotide binding]; other site 1124983013661 salt bridge; other site 1124983013662 sequence-specific DNA binding site [nucleotide binding]; other site 1124983013663 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1124983013664 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1124983013665 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1124983013666 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124983013667 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1124983013668 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1124983013669 putative heme binding pocket [chemical binding]; other site 1124983013670 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1124983013671 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1124983013672 Sodium Bile acid symporter family; Region: SBF; pfam01758 1124983013673 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1124983013674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983013675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983013676 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124983013677 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1124983013678 putative acyl-acceptor binding pocket; other site 1124983013679 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 1124983013680 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1124983013681 gating phenylalanine in ion channel; other site 1124983013682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983013683 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983013684 putative substrate translocation pore; other site 1124983013685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983013686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983013687 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1124983013688 Na binding site [ion binding]; other site 1124983013689 PAS domain; Region: PAS; smart00091 1124983013690 PAS fold; Region: PAS_7; pfam12860 1124983013691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983013692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983013693 dimer interface [polypeptide binding]; other site 1124983013694 phosphorylation site [posttranslational modification] 1124983013695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013696 ATP binding site [chemical binding]; other site 1124983013697 Mg2+ binding site [ion binding]; other site 1124983013698 G-X-G motif; other site 1124983013699 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983013700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013701 active site 1124983013702 phosphorylation site [posttranslational modification] 1124983013703 intermolecular recognition site; other site 1124983013704 dimerization interface [polypeptide binding]; other site 1124983013705 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1124983013706 RmuC family; Region: RmuC; pfam02646 1124983013707 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1124983013708 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1124983013709 catalytic residues [active] 1124983013710 dimer interface [polypeptide binding]; other site 1124983013711 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983013712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983013713 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1124983013714 MarR family; Region: MarR_2; pfam12802 1124983013715 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1124983013716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1124983013717 catalytic core [active] 1124983013718 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1124983013719 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1124983013720 putative dimer interface [polypeptide binding]; other site 1124983013721 active site pocket [active] 1124983013722 putative cataytic base [active] 1124983013723 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1124983013724 homotrimer interface [polypeptide binding]; other site 1124983013725 Walker A motif; other site 1124983013726 GTP binding site [chemical binding]; other site 1124983013727 Walker B motif; other site 1124983013728 cobyric acid synthase; Provisional; Region: PRK00784 1124983013729 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1124983013730 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1124983013731 catalytic triad [active] 1124983013732 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1124983013733 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983013734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983013735 homodimer interface [polypeptide binding]; other site 1124983013736 catalytic residue [active] 1124983013737 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1124983013738 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1124983013739 putative FMN binding site [chemical binding]; other site 1124983013740 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1124983013741 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1124983013742 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1124983013743 catalytic triad [active] 1124983013744 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1124983013745 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1124983013746 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1124983013747 Walker A motif; other site 1124983013748 homodimer interface [polypeptide binding]; other site 1124983013749 ATP binding site [chemical binding]; other site 1124983013750 hydroxycobalamin binding site [chemical binding]; other site 1124983013751 Walker B motif; other site 1124983013752 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1124983013753 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1124983013754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1124983013755 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1124983013756 NlpC/P60 family; Region: NLPC_P60; pfam00877 1124983013757 NlpC/P60 family; Region: NLPC_P60; pfam00877 1124983013758 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1124983013759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983013760 Walker A motif; other site 1124983013761 ATP binding site [chemical binding]; other site 1124983013762 Walker B motif; other site 1124983013763 arginine finger; other site 1124983013764 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1124983013765 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1124983013766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 1124983013767 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1124983013768 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1124983013769 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1124983013770 dimerization interface [polypeptide binding]; other site 1124983013771 putative ATP binding site [chemical binding]; other site 1124983013772 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1124983013773 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1124983013774 active site 1124983013775 substrate binding site [chemical binding]; other site 1124983013776 cosubstrate binding site; other site 1124983013777 catalytic site [active] 1124983013778 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1124983013779 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1124983013780 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1124983013781 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1124983013782 homodimer interface [polypeptide binding]; other site 1124983013783 metal binding site [ion binding]; metal-binding site 1124983013784 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1124983013785 homodimer interface [polypeptide binding]; other site 1124983013786 active site 1124983013787 putative chemical substrate binding site [chemical binding]; other site 1124983013788 metal binding site [ion binding]; metal-binding site 1124983013789 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1124983013790 HD domain; Region: HD_4; pfam13328 1124983013791 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1124983013792 synthetase active site [active] 1124983013793 NTP binding site [chemical binding]; other site 1124983013794 metal binding site [ion binding]; metal-binding site 1124983013795 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1124983013796 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1124983013797 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1124983013798 TRAM domain; Region: TRAM; pfam01938 1124983013799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983013800 S-adenosylmethionine binding site [chemical binding]; other site 1124983013801 cysteine synthase B; Region: cysM; TIGR01138 1124983013802 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1124983013803 dimer interface [polypeptide binding]; other site 1124983013804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983013805 catalytic residue [active] 1124983013806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983013807 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983013808 dimerization interface [polypeptide binding]; other site 1124983013809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983013810 dimer interface [polypeptide binding]; other site 1124983013811 phosphorylation site [posttranslational modification] 1124983013812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013813 ATP binding site [chemical binding]; other site 1124983013814 Mg2+ binding site [ion binding]; other site 1124983013815 G-X-G motif; other site 1124983013816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983013817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013818 active site 1124983013819 phosphorylation site [posttranslational modification] 1124983013820 intermolecular recognition site; other site 1124983013821 dimerization interface [polypeptide binding]; other site 1124983013822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983013823 DNA binding site [nucleotide binding] 1124983013824 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1124983013825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983013826 dimerization interface [polypeptide binding]; other site 1124983013827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983013828 dimer interface [polypeptide binding]; other site 1124983013829 phosphorylation site [posttranslational modification] 1124983013830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013831 ATP binding site [chemical binding]; other site 1124983013832 Mg2+ binding site [ion binding]; other site 1124983013833 G-X-G motif; other site 1124983013834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013835 active site 1124983013836 phosphorylation site [posttranslational modification] 1124983013837 intermolecular recognition site; other site 1124983013838 dimerization interface [polypeptide binding]; other site 1124983013839 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983013840 putative binding surface; other site 1124983013841 active site 1124983013842 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1124983013843 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1124983013844 putative ligand binding site [chemical binding]; other site 1124983013845 putative NAD binding site [chemical binding]; other site 1124983013846 catalytic site [active] 1124983013847 META domain; Region: META; pfam03724 1124983013848 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1124983013849 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1124983013850 catalytic residues [active] 1124983013851 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1124983013852 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983013853 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1124983013854 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1124983013855 catalytic core [active] 1124983013856 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1124983013857 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1124983013858 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1124983013859 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1124983013860 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1124983013861 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1124983013862 Ligand Binding Site [chemical binding]; other site 1124983013863 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1124983013864 hypothetical protein; Provisional; Region: PRK04860 1124983013865 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1124983013866 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1124983013867 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1124983013868 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1124983013869 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124983013870 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983013871 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983013872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983013873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1124983013874 dimer interface [polypeptide binding]; other site 1124983013875 phosphorylation site [posttranslational modification] 1124983013876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013877 ATP binding site [chemical binding]; other site 1124983013878 G-X-G motif; other site 1124983013879 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1124983013880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013881 active site 1124983013882 phosphorylation site [posttranslational modification] 1124983013883 intermolecular recognition site; other site 1124983013884 dimerization interface [polypeptide binding]; other site 1124983013885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983013886 DNA binding site [nucleotide binding] 1124983013887 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1124983013888 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983013889 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124983013890 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1124983013891 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1124983013892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983013893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983013894 dimerization interface [polypeptide binding]; other site 1124983013895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983013896 dimer interface [polypeptide binding]; other site 1124983013897 phosphorylation site [posttranslational modification] 1124983013898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013899 ATP binding site [chemical binding]; other site 1124983013900 Mg2+ binding site [ion binding]; other site 1124983013901 G-X-G motif; other site 1124983013902 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1124983013903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013904 active site 1124983013905 phosphorylation site [posttranslational modification] 1124983013906 intermolecular recognition site; other site 1124983013907 dimerization interface [polypeptide binding]; other site 1124983013908 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983013909 DNA binding site [nucleotide binding] 1124983013910 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1124983013911 ATP cone domain; Region: ATP-cone; pfam03477 1124983013912 ATP cone domain; Region: ATP-cone; pfam03477 1124983013913 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1124983013914 active site 1124983013915 dimer interface [polypeptide binding]; other site 1124983013916 catalytic residues [active] 1124983013917 effector binding site; other site 1124983013918 R2 peptide binding site; other site 1124983013919 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1124983013920 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124983013921 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1124983013922 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1124983013923 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1124983013924 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1124983013925 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1124983013926 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1124983013927 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1124983013928 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1124983013929 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1124983013930 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1124983013931 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1124983013932 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1124983013933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983013934 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1124983013935 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983013936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013937 active site 1124983013938 phosphorylation site [posttranslational modification] 1124983013939 intermolecular recognition site; other site 1124983013940 dimerization interface [polypeptide binding]; other site 1124983013941 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1124983013942 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1124983013943 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1124983013944 FlgN protein; Region: FlgN; pfam05130 1124983013945 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1124983013946 PilZ domain; Region: PilZ; pfam07238 1124983013947 putative MFS family transporter protein; Provisional; Region: PRK03633 1124983013948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983013949 putative substrate translocation pore; other site 1124983013950 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1124983013951 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124983013952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983013953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983013954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983013955 dimerization interface [polypeptide binding]; other site 1124983013956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983013957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983013958 ATP binding site [chemical binding]; other site 1124983013959 Mg2+ binding site [ion binding]; other site 1124983013960 G-X-G motif; other site 1124983013961 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1124983013962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983013963 active site 1124983013964 phosphorylation site [posttranslational modification] 1124983013965 intermolecular recognition site; other site 1124983013966 dimerization interface [polypeptide binding]; other site 1124983013967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983013968 binding surface 1124983013969 TPR motif; other site 1124983013970 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1124983013971 TPR repeat; Region: TPR_11; pfam13414 1124983013972 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1124983013973 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1124983013974 Arc-like DNA binding domain; Region: Arc; pfam03869 1124983013975 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1124983013976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1124983013977 Divalent cation transporter; Region: MgtE; cl00786 1124983013978 carbon storage regulator; Provisional; Region: PRK01712 1124983013979 aspartate kinase; Reviewed; Region: PRK06635 1124983013980 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1124983013981 putative nucleotide binding site [chemical binding]; other site 1124983013982 putative catalytic residues [active] 1124983013983 putative Mg ion binding site [ion binding]; other site 1124983013984 putative aspartate binding site [chemical binding]; other site 1124983013985 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1124983013986 putative allosteric regulatory site; other site 1124983013987 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1124983013988 putative allosteric regulatory residue; other site 1124983013989 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1124983013990 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1124983013991 motif 1; other site 1124983013992 active site 1124983013993 motif 2; other site 1124983013994 motif 3; other site 1124983013995 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1124983013996 DHHA1 domain; Region: DHHA1; pfam02272 1124983013997 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1124983013998 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1124983013999 tetramer interface [polypeptide binding]; other site 1124983014000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983014001 catalytic residue [active] 1124983014002 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 1124983014003 active site 1124983014004 homopentamer interface [polypeptide binding]; other site 1124983014005 dimer interface [polypeptide binding]; other site 1124983014006 succinylglutamate desuccinylase; Provisional; Region: PRK05324 1124983014007 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1124983014008 active site 1124983014009 Zn binding site [ion binding]; other site 1124983014010 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 1124983014011 succinylarginine dihydrolase; Provisional; Region: PRK13281 1124983014012 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1124983014013 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1124983014014 NAD(P) binding site [chemical binding]; other site 1124983014015 catalytic residues [active] 1124983014016 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1124983014017 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 1124983014018 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1124983014019 arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245 1124983014020 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1124983014021 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983014022 inhibitor-cofactor binding pocket; inhibition site 1124983014023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983014024 catalytic residue [active] 1124983014025 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1124983014026 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1124983014027 conserved cys residue [active] 1124983014028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983014029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983014030 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1124983014031 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983014032 Walker A/P-loop; other site 1124983014033 ATP binding site [chemical binding]; other site 1124983014034 Q-loop/lid; other site 1124983014035 ABC transporter signature motif; other site 1124983014036 Walker B; other site 1124983014037 D-loop; other site 1124983014038 H-loop/switch region; other site 1124983014039 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1124983014040 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1124983014041 active site 1124983014042 Zn binding site [ion binding]; other site 1124983014043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983014044 dimer interface [polypeptide binding]; other site 1124983014045 conserved gate region; other site 1124983014046 putative PBP binding loops; other site 1124983014047 ABC-ATPase subunit interface; other site 1124983014048 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983014049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983014050 dimer interface [polypeptide binding]; other site 1124983014051 conserved gate region; other site 1124983014052 putative PBP binding loops; other site 1124983014053 ABC-ATPase subunit interface; other site 1124983014054 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1124983014055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983014056 substrate binding pocket [chemical binding]; other site 1124983014057 membrane-bound complex binding site; other site 1124983014058 hinge residues; other site 1124983014059 acetyl-CoA synthetase; Provisional; Region: PRK00174 1124983014060 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1124983014061 active site 1124983014062 CoA binding site [chemical binding]; other site 1124983014063 acyl-activating enzyme (AAE) consensus motif; other site 1124983014064 AMP binding site [chemical binding]; other site 1124983014065 acetate binding site [chemical binding]; other site 1124983014066 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1124983014067 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1124983014068 dimer interface [polypeptide binding]; other site 1124983014069 putative radical transfer pathway; other site 1124983014070 diiron center [ion binding]; other site 1124983014071 tyrosyl radical; other site 1124983014072 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1124983014073 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1124983014074 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983014075 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983014076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983014077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1124983014078 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1124983014079 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1124983014080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983014081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983014082 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1124983014083 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1124983014084 MASE2 domain; Region: MASE2; pfam05230 1124983014085 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983014086 metal binding site [ion binding]; metal-binding site 1124983014087 active site 1124983014088 I-site; other site 1124983014089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983014090 PAS domain; Region: PAS_9; pfam13426 1124983014091 putative active site [active] 1124983014092 heme pocket [chemical binding]; other site 1124983014093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983014094 PAS domain; Region: PAS_9; pfam13426 1124983014095 putative active site [active] 1124983014096 heme pocket [chemical binding]; other site 1124983014097 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983014098 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983014099 dimer interface [polypeptide binding]; other site 1124983014100 putative CheW interface [polypeptide binding]; other site 1124983014101 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1124983014102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983014103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983014105 dimerization interface [polypeptide binding]; other site 1124983014106 hypothetical protein; Validated; Region: PRK06186 1124983014107 conserved cys residue [active] 1124983014108 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1124983014109 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 1124983014110 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1124983014111 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1124983014112 active site 1124983014113 catalytic site [active] 1124983014114 metal binding site [ion binding]; metal-binding site 1124983014115 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 1124983014116 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1124983014117 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1124983014118 Predicted membrane protein [Function unknown]; Region: COG3212 1124983014119 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1124983014120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983014121 dimerization interface [polypeptide binding]; other site 1124983014122 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983014123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983014124 dimer interface [polypeptide binding]; other site 1124983014125 putative CheW interface [polypeptide binding]; other site 1124983014126 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1124983014127 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1124983014128 Cl binding site [ion binding]; other site 1124983014129 oligomer interface [polypeptide binding]; other site 1124983014130 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1124983014131 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1124983014132 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1124983014133 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1124983014134 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1124983014135 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 1124983014136 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124983014137 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1124983014138 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1124983014139 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124983014140 carboxyltransferase (CT) interaction site; other site 1124983014141 biotinylation site [posttranslational modification]; other site 1124983014142 hypothetical protein; Provisional; Region: PRK12569 1124983014143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983014144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014145 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1124983014146 putative substrate binding pocket [chemical binding]; other site 1124983014147 dimerization interface [polypeptide binding]; other site 1124983014148 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1124983014149 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1124983014150 mce related protein; Region: MCE; pfam02470 1124983014151 mce related protein; Region: MCE; pfam02470 1124983014152 mce related protein; Region: MCE; pfam02470 1124983014153 Paraquat-inducible protein A; Region: PqiA; pfam04403 1124983014154 Paraquat-inducible protein A; Region: PqiA; pfam04403 1124983014155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983014156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983014157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983014158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983014160 dimerization interface [polypeptide binding]; other site 1124983014161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983014162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983014164 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1124983014165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983014166 NAD(P) binding site [chemical binding]; other site 1124983014167 active site 1124983014168 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1124983014169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983014170 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1124983014171 DNA binding residues [nucleotide binding] 1124983014172 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1124983014173 putative hydrophobic ligand binding site [chemical binding]; other site 1124983014174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1124983014175 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1124983014176 SnoaL-like domain; Region: SnoaL_3; pfam13474 1124983014177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983014178 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983014179 Coenzyme A binding pocket [chemical binding]; other site 1124983014180 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983014181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983014182 Coenzyme A binding pocket [chemical binding]; other site 1124983014183 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1124983014184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983014185 active site 1124983014186 phosphorylation site [posttranslational modification] 1124983014187 intermolecular recognition site; other site 1124983014188 dimerization interface [polypeptide binding]; other site 1124983014189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983014190 DNA binding site [nucleotide binding] 1124983014191 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1124983014192 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1124983014193 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1124983014194 Ligand Binding Site [chemical binding]; other site 1124983014195 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1124983014196 GAF domain; Region: GAF_3; pfam13492 1124983014197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983014198 dimer interface [polypeptide binding]; other site 1124983014199 phosphorylation site [posttranslational modification] 1124983014200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983014201 ATP binding site [chemical binding]; other site 1124983014202 Mg2+ binding site [ion binding]; other site 1124983014203 G-X-G motif; other site 1124983014204 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1124983014205 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124983014206 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1124983014207 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1124983014208 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 1124983014209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1124983014210 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983014211 aminotransferase; Validated; Region: PRK08175 1124983014212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983014213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983014214 homodimer interface [polypeptide binding]; other site 1124983014215 catalytic residue [active] 1124983014216 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1124983014217 GntP family permease; Region: GntP_permease; pfam02447 1124983014218 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1124983014219 AAA domain; Region: AAA_33; pfam13671 1124983014220 ATP-binding site [chemical binding]; other site 1124983014221 Gluconate-6-phosphate binding site [chemical binding]; other site 1124983014222 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1124983014223 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1124983014224 DNA binding site [nucleotide binding] 1124983014225 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1124983014226 putative ligand binding site [chemical binding]; other site 1124983014227 putative dimerization interface [polypeptide binding]; other site 1124983014228 LysE type translocator; Region: LysE; cl00565 1124983014229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983014231 dimerization interface [polypeptide binding]; other site 1124983014232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983014233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983014234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983014236 dimerization interface [polypeptide binding]; other site 1124983014237 Predicted membrane protein [Function unknown]; Region: COG4125 1124983014238 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1124983014239 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1124983014240 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1124983014241 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983014242 putative C-terminal domain interface [polypeptide binding]; other site 1124983014243 putative GSH binding site (G-site) [chemical binding]; other site 1124983014244 putative dimer interface [polypeptide binding]; other site 1124983014245 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1124983014246 putative N-terminal domain interface [polypeptide binding]; other site 1124983014247 putative dimer interface [polypeptide binding]; other site 1124983014248 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983014249 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983014250 extended (e) SDRs; Region: SDR_e; cd08946 1124983014251 NAD(P) binding site [chemical binding]; other site 1124983014252 active site 1124983014253 substrate binding site [chemical binding]; other site 1124983014254 benzoate transport; Region: 2A0115; TIGR00895 1124983014255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983014256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983014257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983014258 PAS domain; Region: PAS_9; pfam13426 1124983014259 putative active site [active] 1124983014260 heme pocket [chemical binding]; other site 1124983014261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983014262 PAS domain; Region: PAS_9; pfam13426 1124983014263 putative active site [active] 1124983014264 heme pocket [chemical binding]; other site 1124983014265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983014266 dimer interface [polypeptide binding]; other site 1124983014267 putative CheW interface [polypeptide binding]; other site 1124983014268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983014269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983014271 dimerization interface [polypeptide binding]; other site 1124983014272 glutathionine S-transferase; Provisional; Region: PRK10542 1124983014273 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1124983014274 C-terminal domain interface [polypeptide binding]; other site 1124983014275 GSH binding site (G-site) [chemical binding]; other site 1124983014276 dimer interface [polypeptide binding]; other site 1124983014277 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1124983014278 dimer interface [polypeptide binding]; other site 1124983014279 N-terminal domain interface [polypeptide binding]; other site 1124983014280 substrate binding pocket (H-site) [chemical binding]; other site 1124983014281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983014282 Coenzyme A binding pocket [chemical binding]; other site 1124983014283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983014284 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1124983014285 active site 1124983014286 catalytic residues [active] 1124983014287 metal binding site [ion binding]; metal-binding site 1124983014288 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1124983014289 CsbD-like; Region: CsbD; pfam05532 1124983014290 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1124983014291 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1124983014292 acyl-activating enzyme (AAE) consensus motif; other site 1124983014293 putative AMP binding site [chemical binding]; other site 1124983014294 putative active site [active] 1124983014295 putative CoA binding site [chemical binding]; other site 1124983014296 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 1124983014297 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1124983014298 acyl-activating enzyme (AAE) consensus motif; other site 1124983014299 putative AMP binding site [chemical binding]; other site 1124983014300 putative active site [active] 1124983014301 putative CoA binding site [chemical binding]; other site 1124983014302 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1124983014303 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983014304 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124983014305 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1124983014306 dimer interaction site [polypeptide binding]; other site 1124983014307 substrate-binding tunnel; other site 1124983014308 active site 1124983014309 catalytic site [active] 1124983014310 substrate binding site [chemical binding]; other site 1124983014311 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1124983014312 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983014313 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983014314 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1124983014315 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1124983014316 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124983014317 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1124983014318 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1124983014319 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1124983014320 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983014321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983014322 catalytic residue [active] 1124983014323 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1124983014324 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1124983014325 active site 1124983014326 intersubunit interface [polypeptide binding]; other site 1124983014327 catalytic residue [active] 1124983014328 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1124983014329 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1124983014330 putative active site [active] 1124983014331 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1124983014332 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1124983014333 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1124983014334 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1124983014335 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124983014336 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124983014337 putative active site [active] 1124983014338 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1124983014339 active site 1124983014340 phosphate binding residues; other site 1124983014341 catalytic residues [active] 1124983014342 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1124983014343 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1124983014344 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1124983014345 Walker A/P-loop; other site 1124983014346 ATP binding site [chemical binding]; other site 1124983014347 Q-loop/lid; other site 1124983014348 ABC transporter signature motif; other site 1124983014349 Walker B; other site 1124983014350 D-loop; other site 1124983014351 H-loop/switch region; other site 1124983014352 TOBE domain; Region: TOBE_2; pfam08402 1124983014353 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1124983014354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983014355 dimer interface [polypeptide binding]; other site 1124983014356 conserved gate region; other site 1124983014357 putative PBP binding loops; other site 1124983014358 ABC-ATPase subunit interface; other site 1124983014359 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124983014360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983014361 dimer interface [polypeptide binding]; other site 1124983014362 conserved gate region; other site 1124983014363 putative PBP binding loops; other site 1124983014364 ABC-ATPase subunit interface; other site 1124983014365 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1124983014366 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1124983014367 dimerization interface [polypeptide binding]; other site 1124983014368 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1124983014369 putative active cleft [active] 1124983014370 HAMP domain; Region: HAMP; pfam00672 1124983014371 dimerization interface [polypeptide binding]; other site 1124983014372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983014373 ATP binding site [chemical binding]; other site 1124983014374 Mg2+ binding site [ion binding]; other site 1124983014375 G-X-G motif; other site 1124983014376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983014377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983014378 active site 1124983014379 phosphorylation site [posttranslational modification] 1124983014380 intermolecular recognition site; other site 1124983014381 dimerization interface [polypeptide binding]; other site 1124983014382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983014383 DNA binding site [nucleotide binding] 1124983014384 glucokinase; Provisional; Region: glk; PRK00292 1124983014385 glucokinase, proteobacterial type; Region: glk; TIGR00749 1124983014386 phosphogluconate dehydratase; Validated; Region: PRK09054 1124983014387 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1124983014388 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1124983014389 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1124983014390 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1124983014391 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1124983014392 active site 1124983014393 dimer interfaces [polypeptide binding]; other site 1124983014394 catalytic residues [active] 1124983014395 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1124983014396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983014397 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983014398 DNA binding residues [nucleotide binding] 1124983014399 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983014400 FecR protein; Region: FecR; pfam04773 1124983014401 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983014402 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1124983014403 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983014404 N-terminal plug; other site 1124983014405 ligand-binding site [chemical binding]; other site 1124983014406 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1124983014407 heme binding pocket [chemical binding]; other site 1124983014408 heme ligand [chemical binding]; other site 1124983014409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1124983014410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983014411 dimerization interface [polypeptide binding]; other site 1124983014412 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983014413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983014414 dimer interface [polypeptide binding]; other site 1124983014415 putative CheW interface [polypeptide binding]; other site 1124983014416 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1124983014417 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1124983014418 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1124983014419 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1124983014420 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1124983014421 minor groove reading motif; other site 1124983014422 helix-hairpin-helix signature motif; other site 1124983014423 substrate binding pocket [chemical binding]; other site 1124983014424 active site 1124983014425 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1124983014426 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1124983014427 arginine deiminase; Provisional; Region: PRK01388 1124983014428 ornithine carbamoyltransferase; Validated; Region: PRK02102 1124983014429 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1124983014430 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1124983014431 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1124983014432 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1124983014433 putative substrate binding site [chemical binding]; other site 1124983014434 nucleotide binding site [chemical binding]; other site 1124983014435 nucleotide binding site [chemical binding]; other site 1124983014436 homodimer interface [polypeptide binding]; other site 1124983014437 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1124983014438 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1124983014439 putative aromatic amino acid binding site; other site 1124983014440 PAS domain; Region: PAS; smart00091 1124983014441 putative active site [active] 1124983014442 heme pocket [chemical binding]; other site 1124983014443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983014444 Walker A motif; other site 1124983014445 ATP binding site [chemical binding]; other site 1124983014446 Walker B motif; other site 1124983014447 arginine finger; other site 1124983014448 glycine cleavage system protein H; Provisional; Region: PRK13380 1124983014449 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1124983014450 lipoyl attachment site [posttranslational modification]; other site 1124983014451 glycine dehydrogenase; Provisional; Region: PRK05367 1124983014452 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1124983014453 tetramer interface [polypeptide binding]; other site 1124983014454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983014455 catalytic residue [active] 1124983014456 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1124983014457 tetramer interface [polypeptide binding]; other site 1124983014458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983014459 catalytic residue [active] 1124983014460 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1124983014461 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1124983014462 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1124983014463 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1124983014464 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1124983014465 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124983014466 DNA-binding site [nucleotide binding]; DNA binding site 1124983014467 RNA-binding motif; other site 1124983014468 RDD family; Region: RDD; pfam06271 1124983014469 quinolinate synthetase; Provisional; Region: PRK09375 1124983014470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1124983014471 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1124983014472 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1124983014473 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1124983014474 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1124983014475 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1124983014476 Thioesterase domain; Region: Thioesterase; pfam00975 1124983014477 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983014478 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983014479 acyl-activating enzyme (AAE) consensus motif; other site 1124983014480 AMP binding site [chemical binding]; other site 1124983014481 active site 1124983014482 CoA binding site [chemical binding]; other site 1124983014483 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1124983014484 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1124983014485 putative NAD(P) binding site [chemical binding]; other site 1124983014486 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 1124983014487 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1124983014488 putative active site [active] 1124983014489 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1124983014490 coenzyme F420 hydrogenase, subunit beta; Region: frhB; TIGR03289 1124983014491 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1124983014492 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1124983014493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983014494 EamA-like transporter family; Region: EamA; pfam00892 1124983014495 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1124983014496 EamA-like transporter family; Region: EamA; pfam00892 1124983014497 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1124983014498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983014499 acyl-activating enzyme (AAE) consensus motif; other site 1124983014500 AMP binding site [chemical binding]; other site 1124983014501 active site 1124983014502 CoA binding site [chemical binding]; other site 1124983014503 Condensation domain; Region: Condensation; pfam00668 1124983014504 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1124983014505 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983014506 inhibitor-cofactor binding pocket; inhibition site 1124983014507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983014508 catalytic residue [active] 1124983014509 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1124983014510 Ligand Binding Site [chemical binding]; other site 1124983014511 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1124983014512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983014513 FeS/SAM binding site; other site 1124983014514 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1124983014515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983014516 binding surface 1124983014517 TPR motif; other site 1124983014518 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983014519 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983014520 ligand binding site [chemical binding]; other site 1124983014521 translocation protein TolB; Provisional; Region: tolB; PRK00178 1124983014522 TolB amino-terminal domain; Region: TolB_N; pfam04052 1124983014523 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1124983014524 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1124983014525 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1124983014526 TolA protein; Region: tolA_full; TIGR02794 1124983014527 TolA protein; Region: tolA_full; TIGR02794 1124983014528 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1124983014529 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1124983014530 TolR protein; Region: tolR; TIGR02801 1124983014531 TolQ protein; Region: tolQ; TIGR02796 1124983014532 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1124983014533 active site 1124983014534 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1124983014535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983014536 Walker A motif; other site 1124983014537 ATP binding site [chemical binding]; other site 1124983014538 Walker B motif; other site 1124983014539 arginine finger; other site 1124983014540 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1124983014541 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1124983014542 RuvA N terminal domain; Region: RuvA_N; pfam01330 1124983014543 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1124983014544 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1124983014545 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1124983014546 active site 1124983014547 putative DNA-binding cleft [nucleotide binding]; other site 1124983014548 dimer interface [polypeptide binding]; other site 1124983014549 hypothetical protein; Validated; Region: PRK00110 1124983014550 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1124983014551 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1124983014552 dimer interface [polypeptide binding]; other site 1124983014553 anticodon binding site; other site 1124983014554 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1124983014555 homodimer interface [polypeptide binding]; other site 1124983014556 motif 1; other site 1124983014557 active site 1124983014558 motif 2; other site 1124983014559 GAD domain; Region: GAD; pfam02938 1124983014560 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1124983014561 active site 1124983014562 motif 3; other site 1124983014563 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1124983014564 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1124983014565 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1124983014566 dimerization interface [polypeptide binding]; other site 1124983014567 DPS ferroxidase diiron center [ion binding]; other site 1124983014568 ion pore; other site 1124983014569 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1124983014570 DNA-binding site [nucleotide binding]; DNA binding site 1124983014571 RNA-binding motif; other site 1124983014572 hypothetical protein; Provisional; Region: PRK00295 1124983014573 HIT domain; Region: HIT; pfam01230 1124983014574 nucleotide binding site/active site [active] 1124983014575 HIT family signature motif; other site 1124983014576 catalytic residue [active] 1124983014577 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983014578 mechanosensitive channel MscS; Provisional; Region: PRK10334 1124983014579 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124983014580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1124983014581 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1124983014582 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1124983014583 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1124983014584 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1124983014585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983014586 dimerization interface [polypeptide binding]; other site 1124983014587 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1124983014588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983014589 putative active site [active] 1124983014590 heme pocket [chemical binding]; other site 1124983014591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983014592 dimer interface [polypeptide binding]; other site 1124983014593 phosphorylation site [posttranslational modification] 1124983014594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983014595 ATP binding site [chemical binding]; other site 1124983014596 Mg2+ binding site [ion binding]; other site 1124983014597 G-X-G motif; other site 1124983014598 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1124983014599 hypothetical protein; Provisional; Region: PRK08999 1124983014600 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1124983014601 active site 1124983014602 8-oxo-dGMP binding site [chemical binding]; other site 1124983014603 nudix motif; other site 1124983014604 metal binding site [ion binding]; metal-binding site 1124983014605 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1124983014606 thiamine phosphate binding site [chemical binding]; other site 1124983014607 active site 1124983014608 pyrophosphate binding site [ion binding]; other site 1124983014609 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1124983014610 heterotetramer interface [polypeptide binding]; other site 1124983014611 active site pocket [active] 1124983014612 cleavage site 1124983014613 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1124983014614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1124983014615 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1124983014616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1124983014617 nucleotide binding region [chemical binding]; other site 1124983014618 ATP-binding site [chemical binding]; other site 1124983014619 SEC-C motif; Region: SEC-C; pfam02810 1124983014620 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1124983014621 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1124983014622 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1124983014623 Cache domain; Region: Cache_1; pfam02743 1124983014624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983014625 dimerization interface [polypeptide binding]; other site 1124983014626 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983014627 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983014628 dimer interface [polypeptide binding]; other site 1124983014629 putative CheW interface [polypeptide binding]; other site 1124983014630 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1124983014631 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1124983014632 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1124983014633 putative active site [active] 1124983014634 putative substrate binding site [chemical binding]; other site 1124983014635 putative cosubstrate binding site; other site 1124983014636 catalytic site [active] 1124983014637 exonuclease I; Provisional; Region: sbcB; PRK11779 1124983014638 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1124983014639 active site 1124983014640 catalytic site [active] 1124983014641 substrate binding site [chemical binding]; other site 1124983014642 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1124983014643 RDD family; Region: RDD; pfam06271 1124983014644 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1124983014645 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1124983014646 MoxR-like ATPases [General function prediction only]; Region: COG0714 1124983014647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983014648 Walker A motif; other site 1124983014649 ATP binding site [chemical binding]; other site 1124983014650 Walker B motif; other site 1124983014651 arginine finger; other site 1124983014652 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1124983014653 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1124983014654 metal ion-dependent adhesion site (MIDAS); other site 1124983014655 PilZ domain; Region: PilZ; pfam07238 1124983014656 pyruvate kinase; Provisional; Region: PRK05826 1124983014657 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1124983014658 domain interfaces; other site 1124983014659 active site 1124983014660 enoyl-CoA hydratase; Provisional; Region: PRK06688 1124983014661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1124983014662 substrate binding site [chemical binding]; other site 1124983014663 oxyanion hole (OAH) forming residues; other site 1124983014664 trimer interface [polypeptide binding]; other site 1124983014665 hypothetical protein; Provisional; Region: PRK05713 1124983014666 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983014667 catalytic loop [active] 1124983014668 iron binding site [ion binding]; other site 1124983014669 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1124983014670 FAD binding pocket [chemical binding]; other site 1124983014671 FAD binding motif [chemical binding]; other site 1124983014672 phosphate binding motif [ion binding]; other site 1124983014673 beta-alpha-beta structure motif; other site 1124983014674 NAD binding pocket [chemical binding]; other site 1124983014675 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983014676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983014677 metal binding site [ion binding]; metal-binding site 1124983014678 active site 1124983014679 I-site; other site 1124983014680 putative fumarate hydratase; Provisional; Region: PRK15392 1124983014681 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1124983014682 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1124983014683 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1124983014684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983014685 dimer interface [polypeptide binding]; other site 1124983014686 phosphorylation site [posttranslational modification] 1124983014687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983014688 ATP binding site [chemical binding]; other site 1124983014689 Mg2+ binding site [ion binding]; other site 1124983014690 G-X-G motif; other site 1124983014691 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983014692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983014693 active site 1124983014694 phosphorylation site [posttranslational modification] 1124983014695 intermolecular recognition site; other site 1124983014696 dimerization interface [polypeptide binding]; other site 1124983014697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983014698 Walker A motif; other site 1124983014699 ATP binding site [chemical binding]; other site 1124983014700 Walker B motif; other site 1124983014701 arginine finger; other site 1124983014702 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1124983014703 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1124983014704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983014705 putative substrate translocation pore; other site 1124983014706 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1124983014707 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1124983014708 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1124983014709 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1124983014710 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1124983014711 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1124983014712 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983014713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983014714 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983014715 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1124983014716 NAD(P) binding site [chemical binding]; other site 1124983014717 catalytic residues [active] 1124983014718 catalytic residues [active] 1124983014719 hypothetical protein; Provisional; Region: PRK07524 1124983014720 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124983014721 PYR/PP interface [polypeptide binding]; other site 1124983014722 dimer interface [polypeptide binding]; other site 1124983014723 TPP binding site [chemical binding]; other site 1124983014724 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124983014725 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1124983014726 TPP-binding site [chemical binding]; other site 1124983014727 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983014728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014729 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983014730 substrate binding pocket [chemical binding]; other site 1124983014731 dimerization interface [polypeptide binding]; other site 1124983014732 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1124983014733 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1124983014734 NAD binding site [chemical binding]; other site 1124983014735 putative active site [active] 1124983014736 substrate binding site [chemical binding]; other site 1124983014737 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1124983014738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983014739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014740 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983014741 putative effector binding pocket; other site 1124983014742 dimerization interface [polypeptide binding]; other site 1124983014743 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983014744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983014745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983014746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983014747 putative substrate translocation pore; other site 1124983014748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983014749 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1124983014750 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1124983014751 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983014752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983014753 NAD(P) binding site [chemical binding]; other site 1124983014754 active site 1124983014755 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1124983014756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983014757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983014758 dimerization interface [polypeptide binding]; other site 1124983014759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1124983014760 ACT domain; Region: ACT_3; pfam10000 1124983014761 Family description; Region: ACT_7; pfam13840 1124983014762 Lysine efflux permease [General function prediction only]; Region: COG1279 1124983014763 superoxide dismutase; Provisional; Region: PRK10543 1124983014764 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1124983014765 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1124983014766 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1124983014767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983014768 metal binding site [ion binding]; metal-binding site 1124983014769 active site 1124983014770 I-site; other site 1124983014771 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983014772 Imelysin; Region: Peptidase_M75; cl09159 1124983014773 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1124983014774 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1124983014775 Imelysin; Region: Peptidase_M75; cl09159 1124983014776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 1124983014777 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1124983014778 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1124983014779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983014780 S-adenosylmethionine binding site [chemical binding]; other site 1124983014781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983014782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983014783 dimer interface [polypeptide binding]; other site 1124983014784 phosphorylation site [posttranslational modification] 1124983014785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983014786 ATP binding site [chemical binding]; other site 1124983014787 Mg2+ binding site [ion binding]; other site 1124983014788 G-X-G motif; other site 1124983014789 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983014790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983014791 active site 1124983014792 phosphorylation site [posttranslational modification] 1124983014793 intermolecular recognition site; other site 1124983014794 dimerization interface [polypeptide binding]; other site 1124983014795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983014796 DNA binding site [nucleotide binding] 1124983014797 Sulfatase; Region: Sulfatase; pfam00884 1124983014798 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1124983014799 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1124983014800 ring oligomerisation interface [polypeptide binding]; other site 1124983014801 ATP/Mg binding site [chemical binding]; other site 1124983014802 stacking interactions; other site 1124983014803 hinge regions; other site 1124983014804 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1124983014805 oligomerisation interface [polypeptide binding]; other site 1124983014806 mobile loop; other site 1124983014807 roof hairpin; other site 1124983014808 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1124983014809 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1124983014810 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1124983014811 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1124983014812 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1124983014813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983014814 NAD(P) binding site [chemical binding]; other site 1124983014815 active site 1124983014816 antiporter inner membrane protein; Provisional; Region: PRK11670 1124983014817 Domain of unknown function DUF59; Region: DUF59; pfam01883 1124983014818 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1124983014819 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1124983014820 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1124983014821 active site 1124983014822 HIGH motif; other site 1124983014823 KMSKS motif; other site 1124983014824 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1124983014825 tRNA binding surface [nucleotide binding]; other site 1124983014826 anticodon binding site; other site 1124983014827 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1124983014828 putative tRNA-binding site [nucleotide binding]; other site 1124983014829 dimer interface [polypeptide binding]; other site 1124983014830 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1124983014831 ferredoxin; Provisional; Region: PRK08764 1124983014832 Putative Fe-S cluster; Region: FeS; pfam04060 1124983014833 4Fe-4S binding domain; Region: Fer4; pfam00037 1124983014834 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1124983014835 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 1124983014836 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1124983014837 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1124983014838 minor groove reading motif; other site 1124983014839 helix-hairpin-helix signature motif; other site 1124983014840 substrate binding pocket [chemical binding]; other site 1124983014841 active site 1124983014842 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1124983014843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983014844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983014845 active site 1124983014846 phosphorylation site [posttranslational modification] 1124983014847 intermolecular recognition site; other site 1124983014848 dimerization interface [polypeptide binding]; other site 1124983014849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983014850 DNA binding residues [nucleotide binding] 1124983014851 dimerization interface [polypeptide binding]; other site 1124983014852 argininosuccinate synthase; Provisional; Region: PRK13820 1124983014853 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1124983014854 ANP binding site [chemical binding]; other site 1124983014855 Substrate Binding Site II [chemical binding]; other site 1124983014856 Substrate Binding Site I [chemical binding]; other site 1124983014857 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983014858 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983014859 ligand binding site [chemical binding]; other site 1124983014860 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1124983014861 active site 1124983014862 substrate binding pocket [chemical binding]; other site 1124983014863 dimer interface [polypeptide binding]; other site 1124983014864 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1124983014865 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1124983014866 dimer interface [polypeptide binding]; other site 1124983014867 catalytic site [active] 1124983014868 putative active site [active] 1124983014869 putative substrate binding site [chemical binding]; other site 1124983014870 peroxidase; Provisional; Region: PRK15000 1124983014871 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1124983014872 dimer interface [polypeptide binding]; other site 1124983014873 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1124983014874 catalytic triad [active] 1124983014875 peroxidatic and resolving cysteines [active] 1124983014876 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1124983014877 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1124983014878 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1124983014879 heme binding site [chemical binding]; other site 1124983014880 ferroxidase pore; other site 1124983014881 ferroxidase diiron center [ion binding]; other site 1124983014882 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1124983014883 putative GSH binding site [chemical binding]; other site 1124983014884 catalytic residues [active] 1124983014885 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1124983014886 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1124983014887 putative [Fe4-S4] binding site [ion binding]; other site 1124983014888 putative molybdopterin cofactor binding site [chemical binding]; other site 1124983014889 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1124983014890 putative molybdopterin cofactor binding site; other site 1124983014891 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1124983014892 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1124983014893 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1124983014894 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1124983014895 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1124983014896 Walker A/P-loop; other site 1124983014897 ATP binding site [chemical binding]; other site 1124983014898 Q-loop/lid; other site 1124983014899 ABC transporter signature motif; other site 1124983014900 Walker B; other site 1124983014901 D-loop; other site 1124983014902 H-loop/switch region; other site 1124983014903 TOBE domain; Region: TOBE_2; pfam08402 1124983014904 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1124983014905 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1124983014906 putative deacylase active site [active] 1124983014907 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1124983014908 amphipathic channel; other site 1124983014909 Asn-Pro-Ala signature motifs; other site 1124983014910 glycerol kinase; Provisional; Region: glpK; PRK00047 1124983014911 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1124983014912 N- and C-terminal domain interface [polypeptide binding]; other site 1124983014913 active site 1124983014914 MgATP binding site [chemical binding]; other site 1124983014915 catalytic site [active] 1124983014916 metal binding site [ion binding]; metal-binding site 1124983014917 glycerol binding site [chemical binding]; other site 1124983014918 homotetramer interface [polypeptide binding]; other site 1124983014919 homodimer interface [polypeptide binding]; other site 1124983014920 protein IIAGlc interface [polypeptide binding]; other site 1124983014921 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1124983014922 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1124983014923 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124983014924 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1124983014925 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1124983014926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983014927 substrate binding pocket [chemical binding]; other site 1124983014928 membrane-bound complex binding site; other site 1124983014929 hinge residues; other site 1124983014930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983014931 dimer interface [polypeptide binding]; other site 1124983014932 conserved gate region; other site 1124983014933 putative PBP binding loops; other site 1124983014934 ABC-ATPase subunit interface; other site 1124983014935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983014936 dimer interface [polypeptide binding]; other site 1124983014937 conserved gate region; other site 1124983014938 putative PBP binding loops; other site 1124983014939 ABC-ATPase subunit interface; other site 1124983014940 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1124983014941 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983014942 Walker A/P-loop; other site 1124983014943 ATP binding site [chemical binding]; other site 1124983014944 Q-loop/lid; other site 1124983014945 ABC transporter signature motif; other site 1124983014946 Walker B; other site 1124983014947 D-loop; other site 1124983014948 H-loop/switch region; other site 1124983014949 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1124983014950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983014951 dimer interface [polypeptide binding]; other site 1124983014952 phosphorylation site [posttranslational modification] 1124983014953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983014954 ATP binding site [chemical binding]; other site 1124983014955 Mg2+ binding site [ion binding]; other site 1124983014956 G-X-G motif; other site 1124983014957 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983014958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983014959 active site 1124983014960 phosphorylation site [posttranslational modification] 1124983014961 intermolecular recognition site; other site 1124983014962 dimerization interface [polypeptide binding]; other site 1124983014963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983014964 Walker A motif; other site 1124983014965 ATP binding site [chemical binding]; other site 1124983014966 Walker B motif; other site 1124983014967 arginine finger; other site 1124983014968 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983014969 GlpM protein; Region: GlpM; pfam06942 1124983014970 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1124983014971 active site 1124983014972 metal binding site [ion binding]; metal-binding site 1124983014973 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1124983014974 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1124983014975 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1124983014976 putative di-iron ligands [ion binding]; other site 1124983014977 MltA-interacting protein MipA; Region: MipA; cl01504 1124983014978 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1124983014979 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983014980 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1124983014981 inhibitor-cofactor binding pocket; inhibition site 1124983014982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983014983 catalytic residue [active] 1124983014984 Esterase/lipase [General function prediction only]; Region: COG1647 1124983014985 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1124983014986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983014987 dimerization interface [polypeptide binding]; other site 1124983014988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983014989 dimer interface [polypeptide binding]; other site 1124983014990 phosphorylation site [posttranslational modification] 1124983014991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983014992 ATP binding site [chemical binding]; other site 1124983014993 Mg2+ binding site [ion binding]; other site 1124983014994 G-X-G motif; other site 1124983014995 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983014996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983014997 active site 1124983014998 phosphorylation site [posttranslational modification] 1124983014999 intermolecular recognition site; other site 1124983015000 dimerization interface [polypeptide binding]; other site 1124983015001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983015002 Walker A motif; other site 1124983015003 ATP binding site [chemical binding]; other site 1124983015004 Walker B motif; other site 1124983015005 arginine finger; other site 1124983015006 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983015007 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1124983015008 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1124983015009 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1124983015010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015011 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1124983015012 putative dimerization interface [polypeptide binding]; other site 1124983015013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1124983015014 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983015015 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1124983015016 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983015017 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1124983015018 nudix motif; other site 1124983015019 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1124983015020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983015021 active site 1124983015022 phosphorylation site [posttranslational modification] 1124983015023 intermolecular recognition site; other site 1124983015024 dimerization interface [polypeptide binding]; other site 1124983015025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983015026 Zn2+ binding site [ion binding]; other site 1124983015027 Mg2+ binding site [ion binding]; other site 1124983015028 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1124983015029 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1124983015030 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124983015031 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1124983015032 putative active site [active] 1124983015033 catalytic triad [active] 1124983015034 putative dimer interface [polypeptide binding]; other site 1124983015035 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983015036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983015037 DNA binding residues [nucleotide binding] 1124983015038 dimerization interface [polypeptide binding]; other site 1124983015039 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1124983015040 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1124983015041 active site 1124983015042 FMN binding site [chemical binding]; other site 1124983015043 substrate binding site [chemical binding]; other site 1124983015044 3Fe-4S cluster binding site [ion binding]; other site 1124983015045 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1124983015046 Cupin domain; Region: Cupin_2; cl17218 1124983015047 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983015048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983015049 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1124983015050 Spore germination protein; Region: Spore_permease; cl17796 1124983015051 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1124983015052 Transglycosylase; Region: Transgly; pfam00912 1124983015053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1124983015054 Predicted transcriptional regulators [Transcription]; Region: COG1695 1124983015055 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1124983015056 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1124983015057 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1124983015058 FAD binding pocket [chemical binding]; other site 1124983015059 FAD binding motif [chemical binding]; other site 1124983015060 phosphate binding motif [ion binding]; other site 1124983015061 NAD binding pocket [chemical binding]; other site 1124983015062 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1124983015063 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1124983015064 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1124983015065 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983015066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983015067 DNA-binding site [nucleotide binding]; DNA binding site 1124983015068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983015069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983015070 homodimer interface [polypeptide binding]; other site 1124983015071 catalytic residue [active] 1124983015072 Benzoate membrane transport protein; Region: BenE; pfam03594 1124983015073 benzoate transporter; Region: benE; TIGR00843 1124983015074 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1124983015075 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1124983015076 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1124983015077 Trp docking motif [polypeptide binding]; other site 1124983015078 putative active site [active] 1124983015079 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1124983015080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983015081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983015082 dimer interface [polypeptide binding]; other site 1124983015083 phosphorylation site [posttranslational modification] 1124983015084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983015085 ATP binding site [chemical binding]; other site 1124983015086 Mg2+ binding site [ion binding]; other site 1124983015087 G-X-G motif; other site 1124983015088 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1124983015089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983015090 active site 1124983015091 phosphorylation site [posttranslational modification] 1124983015092 intermolecular recognition site; other site 1124983015093 dimerization interface [polypeptide binding]; other site 1124983015094 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983015095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983015096 active site 1124983015097 phosphorylation site [posttranslational modification] 1124983015098 intermolecular recognition site; other site 1124983015099 dimerization interface [polypeptide binding]; other site 1124983015100 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983015101 DNA binding residues [nucleotide binding] 1124983015102 dimerization interface [polypeptide binding]; other site 1124983015103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983015104 dimerization interface [polypeptide binding]; other site 1124983015105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983015106 metal binding site [ion binding]; metal-binding site 1124983015107 active site 1124983015108 I-site; other site 1124983015109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983015110 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1124983015111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983015112 Walker A motif; other site 1124983015113 ATP binding site [chemical binding]; other site 1124983015114 Walker B motif; other site 1124983015115 arginine finger; other site 1124983015116 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1124983015117 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1124983015118 YhhN-like protein; Region: YhhN; pfam07947 1124983015119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983015120 S-adenosylmethionine binding site [chemical binding]; other site 1124983015121 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1124983015122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983015123 S-adenosylmethionine binding site [chemical binding]; other site 1124983015124 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1124983015125 nucleoside/Zn binding site; other site 1124983015126 dimer interface [polypeptide binding]; other site 1124983015127 catalytic motif [active] 1124983015128 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1124983015129 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1124983015130 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1124983015131 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1124983015132 active site turn [active] 1124983015133 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1124983015134 HPr interaction site; other site 1124983015135 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1124983015136 active site 1124983015137 phosphorylation site [posttranslational modification] 1124983015138 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1124983015139 dimerization domain swap beta strand [polypeptide binding]; other site 1124983015140 regulatory protein interface [polypeptide binding]; other site 1124983015141 active site 1124983015142 regulatory phosphorylation site [posttranslational modification]; other site 1124983015143 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1124983015144 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1124983015145 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1124983015146 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1124983015147 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1124983015148 trimer interface; other site 1124983015149 sugar binding site [chemical binding]; other site 1124983015150 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1124983015151 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1124983015152 Ca binding site [ion binding]; other site 1124983015153 active site 1124983015154 catalytic site [active] 1124983015155 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1124983015156 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1124983015157 active site turn [active] 1124983015158 phosphorylation site [posttranslational modification] 1124983015159 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1124983015160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983015161 DNA-binding site [nucleotide binding]; DNA binding site 1124983015162 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1124983015163 UTRA domain; Region: UTRA; pfam07702 1124983015164 GXWXG protein; Region: GXWXG; pfam14231 1124983015165 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1124983015166 GMP synthase; Reviewed; Region: guaA; PRK00074 1124983015167 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1124983015168 AMP/PPi binding site [chemical binding]; other site 1124983015169 candidate oxyanion hole; other site 1124983015170 catalytic triad [active] 1124983015171 potential glutamine specificity residues [chemical binding]; other site 1124983015172 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1124983015173 ATP Binding subdomain [chemical binding]; other site 1124983015174 Ligand Binding sites [chemical binding]; other site 1124983015175 Dimerization subdomain; other site 1124983015176 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1124983015177 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1124983015178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1124983015179 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1124983015180 active site 1124983015181 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1124983015182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015183 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1124983015184 dimerization interface [polypeptide binding]; other site 1124983015185 substrate binding pocket [chemical binding]; other site 1124983015186 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1124983015187 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1124983015188 generic binding surface II; other site 1124983015189 generic binding surface I; other site 1124983015190 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1124983015191 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124983015192 2-isopropylmalate synthase; Validated; Region: PRK03739 1124983015193 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1124983015194 active site 1124983015195 catalytic residues [active] 1124983015196 metal binding site [ion binding]; metal-binding site 1124983015197 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1124983015198 C-N hydrolase family amidase; Provisional; Region: PRK10438 1124983015199 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1124983015200 putative active site [active] 1124983015201 catalytic triad [active] 1124983015202 dimer interface [polypeptide binding]; other site 1124983015203 multimer interface [polypeptide binding]; other site 1124983015204 methionine aminotransferase; Validated; Region: PRK09082 1124983015205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983015206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983015207 homodimer interface [polypeptide binding]; other site 1124983015208 catalytic residue [active] 1124983015209 GTP-binding protein Der; Reviewed; Region: PRK00093 1124983015210 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1124983015211 G1 box; other site 1124983015212 GTP/Mg2+ binding site [chemical binding]; other site 1124983015213 Switch I region; other site 1124983015214 G2 box; other site 1124983015215 Switch II region; other site 1124983015216 G3 box; other site 1124983015217 G4 box; other site 1124983015218 G5 box; other site 1124983015219 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1124983015220 G1 box; other site 1124983015221 GTP/Mg2+ binding site [chemical binding]; other site 1124983015222 Switch I region; other site 1124983015223 G2 box; other site 1124983015224 G3 box; other site 1124983015225 Switch II region; other site 1124983015226 G4 box; other site 1124983015227 G5 box; other site 1124983015228 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1124983015229 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1124983015230 Trp docking motif [polypeptide binding]; other site 1124983015231 active site 1124983015232 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1124983015233 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1124983015234 dimer interface [polypeptide binding]; other site 1124983015235 motif 1; other site 1124983015236 active site 1124983015237 motif 2; other site 1124983015238 motif 3; other site 1124983015239 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1124983015240 anticodon binding site; other site 1124983015241 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1124983015242 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1124983015243 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1124983015244 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1124983015245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983015246 non-specific DNA binding site [nucleotide binding]; other site 1124983015247 salt bridge; other site 1124983015248 sequence-specific DNA binding site [nucleotide binding]; other site 1124983015249 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1124983015250 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1124983015251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983015252 TPR motif; other site 1124983015253 binding surface 1124983015254 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1124983015255 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983015256 FeS/SAM binding site; other site 1124983015257 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1124983015258 active site 1124983015259 multimer interface [polypeptide binding]; other site 1124983015260 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 1124983015261 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1124983015262 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983015263 catalytic loop [active] 1124983015264 iron binding site [ion binding]; other site 1124983015265 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1124983015266 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1124983015267 nucleotide binding site [chemical binding]; other site 1124983015268 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1124983015269 SBD interface [polypeptide binding]; other site 1124983015270 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1124983015271 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124983015272 HSP70 interaction site [polypeptide binding]; other site 1124983015273 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1124983015274 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1124983015275 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1124983015276 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1124983015277 trimerization site [polypeptide binding]; other site 1124983015278 active site 1124983015279 cysteine desulfurase; Provisional; Region: PRK14012 1124983015280 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1124983015281 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983015282 catalytic residue [active] 1124983015283 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1124983015284 Rrf2 family protein; Region: rrf2_super; TIGR00738 1124983015285 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1124983015286 serine O-acetyltransferase; Region: cysE; TIGR01172 1124983015287 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1124983015288 trimer interface [polypeptide binding]; other site 1124983015289 active site 1124983015290 substrate binding site [chemical binding]; other site 1124983015291 CoA binding site [chemical binding]; other site 1124983015292 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1124983015293 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1124983015294 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1124983015295 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1124983015296 active site 1124983015297 dimerization interface [polypeptide binding]; other site 1124983015298 hypothetical protein; Provisional; Region: PRK11280 1124983015299 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1124983015300 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1124983015301 Protein export membrane protein; Region: SecD_SecF; pfam02355 1124983015302 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1124983015303 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1124983015304 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1124983015305 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1124983015306 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1124983015307 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1124983015308 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1124983015309 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1124983015310 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1124983015311 Peptidase M35 family; Region: M35_like; cl03449 1124983015312 active site 1124983015313 Zn binding site [ion binding]; other site 1124983015314 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1124983015315 EamA-like transporter family; Region: EamA; pfam00892 1124983015316 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1124983015317 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983015318 inhibitor-cofactor binding pocket; inhibition site 1124983015319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983015320 catalytic residue [active] 1124983015321 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1124983015322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983015323 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1124983015324 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983015325 putative C-terminal domain interface [polypeptide binding]; other site 1124983015326 putative GSH binding site (G-site) [chemical binding]; other site 1124983015327 putative dimer interface [polypeptide binding]; other site 1124983015328 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1124983015329 putative N-terminal domain interface [polypeptide binding]; other site 1124983015330 putative dimer interface [polypeptide binding]; other site 1124983015331 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983015332 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983015333 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983015334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983015335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983015336 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983015337 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1124983015338 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124983015339 active site 1124983015340 HAMP domain; Region: HAMP; pfam00672 1124983015341 dimerization interface [polypeptide binding]; other site 1124983015342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983015343 dimer interface [polypeptide binding]; other site 1124983015344 phosphorylation site [posttranslational modification] 1124983015345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983015346 ATP binding site [chemical binding]; other site 1124983015347 Mg2+ binding site [ion binding]; other site 1124983015348 G-X-G motif; other site 1124983015349 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1124983015350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983015351 active site 1124983015352 phosphorylation site [posttranslational modification] 1124983015353 intermolecular recognition site; other site 1124983015354 dimerization interface [polypeptide binding]; other site 1124983015355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983015356 DNA binding site [nucleotide binding] 1124983015357 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983015358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015359 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983015360 dimerization interface [polypeptide binding]; other site 1124983015361 substrate binding pocket [chemical binding]; other site 1124983015362 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1124983015363 metal binding site [ion binding]; metal-binding site 1124983015364 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1124983015365 putative active site [active] 1124983015366 putative metal binding site [ion binding]; other site 1124983015367 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983015368 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983015369 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983015370 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983015371 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983015372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983015373 putative DNA binding site [nucleotide binding]; other site 1124983015374 putative Zn2+ binding site [ion binding]; other site 1124983015375 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1124983015376 active site residue [active] 1124983015377 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 1124983015378 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124983015379 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1124983015380 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1124983015381 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983015382 inhibitor-cofactor binding pocket; inhibition site 1124983015383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983015384 catalytic residue [active] 1124983015385 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1124983015386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983015387 Coenzyme A binding pocket [chemical binding]; other site 1124983015388 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1124983015389 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 1124983015390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983015391 Coenzyme A binding pocket [chemical binding]; other site 1124983015392 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1124983015393 nucleotide binding site/active site [active] 1124983015394 HIT family signature motif; other site 1124983015395 catalytic residue [active] 1124983015396 hypothetical protein; Provisional; Region: PRK07524 1124983015397 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124983015398 PYR/PP interface [polypeptide binding]; other site 1124983015399 dimer interface [polypeptide binding]; other site 1124983015400 TPP binding site [chemical binding]; other site 1124983015401 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124983015402 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1124983015403 TPP-binding site [chemical binding]; other site 1124983015404 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983015405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983015406 putative DNA binding site [nucleotide binding]; other site 1124983015407 putative Zn2+ binding site [ion binding]; other site 1124983015408 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1124983015409 dimerization interface [polypeptide binding]; other site 1124983015410 substrate binding pocket [chemical binding]; other site 1124983015411 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1124983015412 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1124983015413 Walker A/P-loop; other site 1124983015414 ATP binding site [chemical binding]; other site 1124983015415 Q-loop/lid; other site 1124983015416 ABC transporter signature motif; other site 1124983015417 Walker B; other site 1124983015418 D-loop; other site 1124983015419 H-loop/switch region; other site 1124983015420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983015421 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983015422 substrate binding pocket [chemical binding]; other site 1124983015423 membrane-bound complex binding site; other site 1124983015424 hinge residues; other site 1124983015425 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983015426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983015427 dimer interface [polypeptide binding]; other site 1124983015428 conserved gate region; other site 1124983015429 putative PBP binding loops; other site 1124983015430 ABC-ATPase subunit interface; other site 1124983015431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983015432 dimer interface [polypeptide binding]; other site 1124983015433 conserved gate region; other site 1124983015434 putative PBP binding loops; other site 1124983015435 ABC-ATPase subunit interface; other site 1124983015436 aspartate aminotransferase; Provisional; Region: PRK05764 1124983015437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983015438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983015439 homodimer interface [polypeptide binding]; other site 1124983015440 catalytic residue [active] 1124983015441 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1124983015442 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1124983015443 active site 1124983015444 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1124983015445 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1124983015446 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1124983015447 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1124983015448 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1124983015449 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983015450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983015451 catalytic residue [active] 1124983015452 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983015453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983015454 non-specific DNA binding site [nucleotide binding]; other site 1124983015455 salt bridge; other site 1124983015456 sequence-specific DNA binding site [nucleotide binding]; other site 1124983015457 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1124983015458 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1124983015459 Ligand Binding Site [chemical binding]; other site 1124983015460 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1124983015461 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1124983015462 UbiA prenyltransferase family; Region: UbiA; pfam01040 1124983015463 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1124983015464 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1124983015465 Subunit I/III interface [polypeptide binding]; other site 1124983015466 Subunit III/IV interface [polypeptide binding]; other site 1124983015467 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1124983015468 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1124983015469 D-pathway; other site 1124983015470 Putative ubiquinol binding site [chemical binding]; other site 1124983015471 Low-spin heme (heme b) binding site [chemical binding]; other site 1124983015472 Putative water exit pathway; other site 1124983015473 Binuclear center (heme o3/CuB) [ion binding]; other site 1124983015474 K-pathway; other site 1124983015475 Putative proton exit pathway; other site 1124983015476 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1124983015477 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1124983015478 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1124983015479 disulfide bond formation protein B; Provisional; Region: PRK02110 1124983015480 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1124983015481 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1124983015482 heme-binding site [chemical binding]; other site 1124983015483 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1124983015484 FAD binding pocket [chemical binding]; other site 1124983015485 FAD binding motif [chemical binding]; other site 1124983015486 phosphate binding motif [ion binding]; other site 1124983015487 beta-alpha-beta structure motif; other site 1124983015488 NAD binding pocket [chemical binding]; other site 1124983015489 Heme binding pocket [chemical binding]; other site 1124983015490 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1124983015491 GAF domain; Region: GAF; pfam01590 1124983015492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983015493 Walker A motif; other site 1124983015494 ATP binding site [chemical binding]; other site 1124983015495 Walker B motif; other site 1124983015496 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1124983015497 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1124983015498 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983015499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983015500 active site 1124983015501 phosphorylation site [posttranslational modification] 1124983015502 intermolecular recognition site; other site 1124983015503 dimerization interface [polypeptide binding]; other site 1124983015504 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983015505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983015506 Coenzyme A binding pocket [chemical binding]; other site 1124983015507 Flagellin N-methylase; Region: FliB; pfam03692 1124983015508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983015509 PAS fold; Region: PAS_3; pfam08447 1124983015510 putative active site [active] 1124983015511 heme pocket [chemical binding]; other site 1124983015512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1124983015513 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983015514 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983015515 dimer interface [polypeptide binding]; other site 1124983015516 putative CheW interface [polypeptide binding]; other site 1124983015517 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1124983015518 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1124983015519 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1124983015520 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1124983015521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983015522 active site 1124983015523 phosphorylation site [posttranslational modification] 1124983015524 intermolecular recognition site; other site 1124983015525 dimerization interface [polypeptide binding]; other site 1124983015526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983015527 DNA binding site [nucleotide binding] 1124983015528 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1124983015529 HAMP domain; Region: HAMP; pfam00672 1124983015530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983015531 dimer interface [polypeptide binding]; other site 1124983015532 phosphorylation site [posttranslational modification] 1124983015533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983015534 ATP binding site [chemical binding]; other site 1124983015535 Mg2+ binding site [ion binding]; other site 1124983015536 G-X-G motif; other site 1124983015537 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983015538 Cache domain; Region: Cache_1; pfam02743 1124983015539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983015540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983015541 metal binding site [ion binding]; metal-binding site 1124983015542 active site 1124983015543 I-site; other site 1124983015544 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1124983015545 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1124983015546 cell division protein FtsZ; Validated; Region: PRK09330 1124983015547 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1124983015548 nucleotide binding site [chemical binding]; other site 1124983015549 SulA interaction site; other site 1124983015550 cell division protein FtsA; Region: ftsA; TIGR01174 1124983015551 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1124983015552 nucleotide binding site [chemical binding]; other site 1124983015553 Cell division protein FtsA; Region: FtsA; pfam14450 1124983015554 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1124983015555 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1124983015556 Cell division protein FtsQ; Region: FtsQ; pfam03799 1124983015557 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1124983015558 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1124983015559 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1124983015560 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1124983015561 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1124983015562 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124983015563 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124983015564 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1124983015565 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1124983015566 active site 1124983015567 homodimer interface [polypeptide binding]; other site 1124983015568 cell division protein FtsW; Region: ftsW; TIGR02614 1124983015569 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1124983015570 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124983015571 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1124983015572 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1124983015573 Mg++ binding site [ion binding]; other site 1124983015574 putative catalytic motif [active] 1124983015575 putative substrate binding site [chemical binding]; other site 1124983015576 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1124983015577 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1124983015578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124983015579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124983015580 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1124983015581 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1124983015582 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124983015583 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124983015584 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1124983015585 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1124983015586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1124983015587 Cell division protein FtsL; Region: FtsL; pfam04999 1124983015588 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1124983015589 MraW methylase family; Region: Methyltransf_5; cl17771 1124983015590 cell division protein MraZ; Reviewed; Region: PRK00326 1124983015591 MraZ protein; Region: MraZ; pfam02381 1124983015592 MraZ protein; Region: MraZ; pfam02381 1124983015593 Predicted methyltransferases [General function prediction only]; Region: COG0313 1124983015594 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1124983015595 putative SAM binding site [chemical binding]; other site 1124983015596 putative homodimer interface [polypeptide binding]; other site 1124983015597 LppC putative lipoprotein; Region: LppC; pfam04348 1124983015598 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1124983015599 putative ligand binding site [chemical binding]; other site 1124983015600 hypothetical protein; Reviewed; Region: PRK12497 1124983015601 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1124983015602 dimer interface [polypeptide binding]; other site 1124983015603 active site 1124983015604 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1124983015605 BON domain; Region: BON; pfam04972 1124983015606 BON domain; Region: BON; pfam04972 1124983015607 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1124983015608 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1124983015609 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1124983015610 C-terminal domain interface [polypeptide binding]; other site 1124983015611 putative GSH binding site (G-site) [chemical binding]; other site 1124983015612 dimer interface [polypeptide binding]; other site 1124983015613 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1124983015614 dimer interface [polypeptide binding]; other site 1124983015615 N-terminal domain interface [polypeptide binding]; other site 1124983015616 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 1124983015617 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1124983015618 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1124983015619 Qi binding site; other site 1124983015620 intrachain domain interface; other site 1124983015621 interchain domain interface [polypeptide binding]; other site 1124983015622 heme bH binding site [chemical binding]; other site 1124983015623 heme bL binding site [chemical binding]; other site 1124983015624 Qo binding site; other site 1124983015625 interchain domain interface [polypeptide binding]; other site 1124983015626 intrachain domain interface; other site 1124983015627 Qi binding site; other site 1124983015628 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1124983015629 Qo binding site; other site 1124983015630 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1124983015631 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1124983015632 [2Fe-2S] cluster binding site [ion binding]; other site 1124983015633 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1124983015634 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1124983015635 23S rRNA interface [nucleotide binding]; other site 1124983015636 L3 interface [polypeptide binding]; other site 1124983015637 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124983015638 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124983015639 active site 1124983015640 catalytic tetrad [active] 1124983015641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1124983015642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983015643 active site 1124983015644 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1124983015645 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1124983015646 conserved cys residue [active] 1124983015647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983015648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983015649 Predicted ATPase [General function prediction only]; Region: COG1485 1124983015650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1124983015651 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1124983015652 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1124983015653 active site 1124983015654 HIGH motif; other site 1124983015655 dimer interface [polypeptide binding]; other site 1124983015656 KMSKS motif; other site 1124983015657 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1124983015658 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1124983015659 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1124983015660 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983015661 ligand binding site [chemical binding]; other site 1124983015662 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1124983015663 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1124983015664 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1124983015665 DNA binding site [nucleotide binding] 1124983015666 active site 1124983015667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1124983015668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983015669 active site 1124983015670 phosphorylation site [posttranslational modification] 1124983015671 intermolecular recognition site; other site 1124983015672 dimerization interface [polypeptide binding]; other site 1124983015673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983015674 DNA binding site [nucleotide binding] 1124983015675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983015676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983015677 dimer interface [polypeptide binding]; other site 1124983015678 phosphorylation site [posttranslational modification] 1124983015679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983015680 ATP binding site [chemical binding]; other site 1124983015681 Mg2+ binding site [ion binding]; other site 1124983015682 G-X-G motif; other site 1124983015683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983015684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015685 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1124983015686 putative substrate binding pocket [chemical binding]; other site 1124983015687 dimerization interface [polypeptide binding]; other site 1124983015688 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1124983015689 AAA ATPase domain; Region: AAA_16; pfam13191 1124983015690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983015691 DNA binding residues [nucleotide binding] 1124983015692 dimerization interface [polypeptide binding]; other site 1124983015693 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1124983015694 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1124983015695 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1124983015696 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1124983015697 acyl-activating enzyme (AAE) consensus motif; other site 1124983015698 AMP binding site [chemical binding]; other site 1124983015699 active site 1124983015700 CoA binding site [chemical binding]; other site 1124983015701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983015702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983015703 putative substrate translocation pore; other site 1124983015704 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983015705 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983015706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983015707 LysE type translocator; Region: LysE; cl00565 1124983015708 glycerate dehydrogenase; Provisional; Region: PRK06487 1124983015709 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1124983015710 putative ligand binding site [chemical binding]; other site 1124983015711 putative NAD binding site [chemical binding]; other site 1124983015712 catalytic site [active] 1124983015713 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1124983015714 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1124983015715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983015716 S-adenosylmethionine binding site [chemical binding]; other site 1124983015717 Predicted membrane protein [Function unknown]; Region: COG2119 1124983015718 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1124983015719 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1124983015720 Peptidase family M48; Region: Peptidase_M48; pfam01435 1124983015721 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983015722 dimerization interface [polypeptide binding]; other site 1124983015723 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983015724 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983015725 dimer interface [polypeptide binding]; other site 1124983015726 putative CheW interface [polypeptide binding]; other site 1124983015727 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1124983015728 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1124983015729 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1124983015730 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1124983015731 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124983015732 putative acyl-acceptor binding pocket; other site 1124983015733 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1124983015734 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1124983015735 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1124983015736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983015737 active site 1124983015738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983015739 active site 1124983015740 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1124983015741 ferrochelatase; Reviewed; Region: hemH; PRK00035 1124983015742 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1124983015743 C-terminal domain interface [polypeptide binding]; other site 1124983015744 active site 1124983015745 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1124983015746 active site 1124983015747 N-terminal domain interface [polypeptide binding]; other site 1124983015748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983015749 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1124983015750 NAD(P) binding site [chemical binding]; other site 1124983015751 active site 1124983015752 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1124983015753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983015754 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 1124983015755 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1124983015756 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1124983015757 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1124983015758 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1124983015759 DNA binding residues [nucleotide binding] 1124983015760 transcriptional regulator MirA; Provisional; Region: PRK15043 1124983015761 B12 binding domain; Region: B12-binding_2; pfam02607 1124983015762 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1124983015763 DNA photolyase; Region: DNA_photolyase; pfam00875 1124983015764 SnoaL-like domain; Region: SnoaL_2; pfam12680 1124983015765 short chain dehydrogenase; Provisional; Region: PRK06101 1124983015766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983015767 NAD(P) binding site [chemical binding]; other site 1124983015768 active site 1124983015769 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1124983015770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983015771 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1124983015772 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1124983015773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983015774 S-adenosylmethionine binding site [chemical binding]; other site 1124983015775 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1124983015776 Flagellin N-methylase; Region: FliB; pfam03692 1124983015777 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1124983015778 glutamate racemase; Provisional; Region: PRK00865 1124983015779 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1124983015780 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1124983015781 ATP binding site [chemical binding]; other site 1124983015782 substrate interface [chemical binding]; other site 1124983015783 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1124983015784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983015785 S-adenosylmethionine binding site [chemical binding]; other site 1124983015786 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1124983015787 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1124983015788 RF-1 domain; Region: RF-1; pfam00472 1124983015789 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1124983015790 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1124983015791 tRNA; other site 1124983015792 putative tRNA binding site [nucleotide binding]; other site 1124983015793 putative NADP binding site [chemical binding]; other site 1124983015794 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1124983015795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983015796 TPR motif; other site 1124983015797 binding surface 1124983015798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983015799 binding surface 1124983015800 TPR motif; other site 1124983015801 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1124983015802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1124983015803 binding surface 1124983015804 TPR motif; other site 1124983015805 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1124983015806 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1124983015807 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1124983015808 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1124983015809 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1124983015810 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1124983015811 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983015812 active site 1124983015813 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1124983015814 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1124983015815 5S rRNA interface [nucleotide binding]; other site 1124983015816 CTC domain interface [polypeptide binding]; other site 1124983015817 L16 interface [polypeptide binding]; other site 1124983015818 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1124983015819 putative active site [active] 1124983015820 catalytic residue [active] 1124983015821 GTP-binding protein YchF; Reviewed; Region: PRK09601 1124983015822 YchF GTPase; Region: YchF; cd01900 1124983015823 G1 box; other site 1124983015824 GTP/Mg2+ binding site [chemical binding]; other site 1124983015825 Switch I region; other site 1124983015826 G2 box; other site 1124983015827 Switch II region; other site 1124983015828 G3 box; other site 1124983015829 G4 box; other site 1124983015830 G5 box; other site 1124983015831 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1124983015832 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1124983015833 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983015834 N-terminal plug; other site 1124983015835 ligand-binding site [chemical binding]; other site 1124983015836 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1124983015837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983015838 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1124983015839 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983015840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983015841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983015842 putative substrate translocation pore; other site 1124983015843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983015844 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983015845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983015847 dimerization interface [polypeptide binding]; other site 1124983015848 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1124983015849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983015850 Walker A/P-loop; other site 1124983015851 ATP binding site [chemical binding]; other site 1124983015852 Q-loop/lid; other site 1124983015853 ABC transporter signature motif; other site 1124983015854 Walker B; other site 1124983015855 D-loop; other site 1124983015856 H-loop/switch region; other site 1124983015857 TOBE domain; Region: TOBE_2; pfam08402 1124983015858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983015859 dimer interface [polypeptide binding]; other site 1124983015860 conserved gate region; other site 1124983015861 putative PBP binding loops; other site 1124983015862 ABC-ATPase subunit interface; other site 1124983015863 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124983015864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983015865 dimer interface [polypeptide binding]; other site 1124983015866 conserved gate region; other site 1124983015867 putative PBP binding loops; other site 1124983015868 ABC-ATPase subunit interface; other site 1124983015869 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1124983015870 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124983015871 amidase; Provisional; Region: PRK07486 1124983015872 Amidase; Region: Amidase; cl11426 1124983015873 integrase; Provisional; Region: PRK09692 1124983015874 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1124983015875 active site 1124983015876 Int/Topo IB signature motif; other site 1124983015877 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1124983015878 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1124983015879 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1124983015880 active site 1124983015881 metal binding site [ion binding]; metal-binding site 1124983015882 interdomain interaction site; other site 1124983015883 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1124983015884 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1124983015885 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1124983015886 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1124983015887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983015888 active site 1124983015889 motif I; other site 1124983015890 motif II; other site 1124983015891 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1124983015892 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1124983015893 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1124983015894 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983015895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983015896 Coenzyme A binding pocket [chemical binding]; other site 1124983015897 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1124983015898 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1124983015899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983015900 non-specific DNA binding site [nucleotide binding]; other site 1124983015901 salt bridge; other site 1124983015902 sequence-specific DNA binding site [nucleotide binding]; other site 1124983015903 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1124983015904 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1124983015905 DNA binding residues [nucleotide binding] 1124983015906 drug binding residues [chemical binding]; other site 1124983015907 dimer interface [polypeptide binding]; other site 1124983015908 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1124983015909 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1124983015910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983015911 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983015912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983015913 Coenzyme A binding pocket [chemical binding]; other site 1124983015914 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1124983015915 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1124983015916 putative active site pocket [active] 1124983015917 dimerization interface [polypeptide binding]; other site 1124983015918 putative catalytic residue [active] 1124983015919 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1124983015920 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1124983015921 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1124983015922 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983015923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983015924 Coenzyme A binding pocket [chemical binding]; other site 1124983015925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1124983015926 LysE type translocator; Region: LysE; cl00565 1124983015927 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983015928 Helix-turn-helix domain; Region: HTH_18; pfam12833 1124983015929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983015930 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1124983015931 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1124983015932 heme binding pocket [chemical binding]; other site 1124983015933 heme ligand [chemical binding]; other site 1124983015934 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1124983015935 PAS domain; Region: PAS; smart00091 1124983015936 GAF domain; Region: GAF; pfam01590 1124983015937 Phytochrome region; Region: PHY; pfam00360 1124983015938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983015939 dimer interface [polypeptide binding]; other site 1124983015940 phosphorylation site [posttranslational modification] 1124983015941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983015942 ATP binding site [chemical binding]; other site 1124983015943 Mg2+ binding site [ion binding]; other site 1124983015944 G-X-G motif; other site 1124983015945 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1124983015946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983015948 dimerization interface [polypeptide binding]; other site 1124983015949 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1124983015950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983015951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015952 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1124983015953 putative effector binding pocket; other site 1124983015954 dimerization interface [polypeptide binding]; other site 1124983015955 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1124983015956 putative deacylase active site [active] 1124983015957 transcriptional regulator; Provisional; Region: PRK10632 1124983015958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983015960 dimerization interface [polypeptide binding]; other site 1124983015961 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1124983015962 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1124983015963 NAD(P) binding site [chemical binding]; other site 1124983015964 active site 1124983015965 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1124983015966 short chain dehydrogenase; Provisional; Region: PRK12744 1124983015967 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1124983015968 NADP binding site [chemical binding]; other site 1124983015969 homodimer interface [polypeptide binding]; other site 1124983015970 active site 1124983015971 substrate binding site [chemical binding]; other site 1124983015972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983015973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983015974 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1124983015975 putative effector binding pocket; other site 1124983015976 putative dimerization interface [polypeptide binding]; other site 1124983015977 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1124983015978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983015979 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1124983015980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983015981 putative active site [active] 1124983015982 heme pocket [chemical binding]; other site 1124983015983 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983015984 dimer interface [polypeptide binding]; other site 1124983015985 putative CheW interface [polypeptide binding]; other site 1124983015986 PAS domain; Region: PAS_9; pfam13426 1124983015987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983015988 putative active site [active] 1124983015989 heme pocket [chemical binding]; other site 1124983015990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983015991 PAS fold; Region: PAS_3; pfam08447 1124983015992 putative active site [active] 1124983015993 heme pocket [chemical binding]; other site 1124983015994 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983015995 dimer interface [polypeptide binding]; other site 1124983015996 putative CheW interface [polypeptide binding]; other site 1124983015997 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1124983015998 homotrimer interaction site [polypeptide binding]; other site 1124983015999 putative active site [active] 1124983016000 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1124983016001 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983016002 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1124983016003 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1124983016004 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983016005 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1124983016006 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1124983016007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983016008 active site 1124983016009 phosphorylation site [posttranslational modification] 1124983016010 intermolecular recognition site; other site 1124983016011 dimerization interface [polypeptide binding]; other site 1124983016012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983016013 DNA binding site [nucleotide binding] 1124983016014 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1124983016015 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1124983016016 GntP family permease; Region: GntP_permease; pfam02447 1124983016017 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1124983016018 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1124983016019 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983016020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983016021 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1124983016022 oligomerization interface [polypeptide binding]; other site 1124983016023 active site 1124983016024 metal binding site [ion binding]; metal-binding site 1124983016025 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983016026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983016027 DNA-binding site [nucleotide binding]; DNA binding site 1124983016028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983016029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983016030 catalytic residue [active] 1124983016031 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1124983016032 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1124983016033 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 1124983016034 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1124983016035 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1124983016036 nucleotide binding site [chemical binding]; other site 1124983016037 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1124983016038 SBD interface [polypeptide binding]; other site 1124983016039 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1124983016040 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124983016041 HSP70 interaction site [polypeptide binding]; other site 1124983016042 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1124983016043 active site clefts [active] 1124983016044 zinc binding site [ion binding]; other site 1124983016045 dimer interface [polypeptide binding]; other site 1124983016046 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1124983016047 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983016048 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1124983016049 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1124983016050 mce related protein; Region: MCE; pfam02470 1124983016051 mce related protein; Region: MCE; pfam02470 1124983016052 mce related protein; Region: MCE; pfam02470 1124983016053 mce related protein; Region: MCE; pfam02470 1124983016054 mce related protein; Region: MCE; pfam02470 1124983016055 mce related protein; Region: MCE; pfam02470 1124983016056 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1124983016057 Paraquat-inducible protein A; Region: PqiA; pfam04403 1124983016058 Paraquat-inducible protein A; Region: PqiA; pfam04403 1124983016059 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1124983016060 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1124983016061 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1124983016062 Moco binding site; other site 1124983016063 metal coordination site [ion binding]; other site 1124983016064 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1124983016065 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1124983016066 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1124983016067 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1124983016068 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1124983016069 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1124983016070 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1124983016071 putative valine binding site [chemical binding]; other site 1124983016072 dimer interface [polypeptide binding]; other site 1124983016073 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1124983016074 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1124983016075 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1124983016076 PYR/PP interface [polypeptide binding]; other site 1124983016077 dimer interface [polypeptide binding]; other site 1124983016078 TPP binding site [chemical binding]; other site 1124983016079 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1124983016080 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1124983016081 TPP-binding site [chemical binding]; other site 1124983016082 dimer interface [polypeptide binding]; other site 1124983016083 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1124983016084 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1124983016085 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1124983016086 Transglycosylase; Region: Transgly; pfam00912 1124983016087 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1124983016088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1124983016089 AAA domain; Region: AAA_33; pfam13671 1124983016090 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1124983016091 active site 1124983016092 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1124983016093 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1124983016094 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1124983016095 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1124983016096 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124983016097 ligand binding site [chemical binding]; other site 1124983016098 flexible hinge region; other site 1124983016099 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1124983016100 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1124983016101 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1124983016102 Walker A/P-loop; other site 1124983016103 ATP binding site [chemical binding]; other site 1124983016104 Q-loop/lid; other site 1124983016105 ABC transporter signature motif; other site 1124983016106 Walker B; other site 1124983016107 D-loop; other site 1124983016108 H-loop/switch region; other site 1124983016109 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1124983016110 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124983016111 ABC-ATPase subunit interface; other site 1124983016112 dimer interface [polypeptide binding]; other site 1124983016113 putative PBP binding regions; other site 1124983016114 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1124983016115 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1124983016116 intersubunit interface [polypeptide binding]; other site 1124983016117 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1124983016118 iron-sulfur cluster [ion binding]; other site 1124983016119 [2Fe-2S] cluster binding site [ion binding]; other site 1124983016120 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1124983016121 hypothetical protein; Provisional; Region: PRK08960 1124983016122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983016123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983016124 homodimer interface [polypeptide binding]; other site 1124983016125 catalytic residue [active] 1124983016126 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1124983016127 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1124983016128 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1124983016129 active site 1124983016130 HIGH motif; other site 1124983016131 nucleotide binding site [chemical binding]; other site 1124983016132 KMSKS motif; other site 1124983016133 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1124983016134 Na binding site [ion binding]; other site 1124983016135 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1124983016136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983016137 putative active site [active] 1124983016138 heme pocket [chemical binding]; other site 1124983016139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983016140 dimer interface [polypeptide binding]; other site 1124983016141 phosphorylation site [posttranslational modification] 1124983016142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983016143 ATP binding site [chemical binding]; other site 1124983016144 Mg2+ binding site [ion binding]; other site 1124983016145 G-X-G motif; other site 1124983016146 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983016147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983016148 active site 1124983016149 phosphorylation site [posttranslational modification] 1124983016150 intermolecular recognition site; other site 1124983016151 dimerization interface [polypeptide binding]; other site 1124983016152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983016153 Walker A motif; other site 1124983016154 ATP binding site [chemical binding]; other site 1124983016155 Walker B motif; other site 1124983016156 arginine finger; other site 1124983016157 poly(A) polymerase; Region: pcnB; TIGR01942 1124983016158 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1124983016159 active site 1124983016160 NTP binding site [chemical binding]; other site 1124983016161 metal binding triad [ion binding]; metal-binding site 1124983016162 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1124983016163 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1124983016164 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1124983016165 catalytic center binding site [active] 1124983016166 ATP binding site [chemical binding]; other site 1124983016167 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1124983016168 oligomerization interface [polypeptide binding]; other site 1124983016169 active site 1124983016170 metal binding site [ion binding]; metal-binding site 1124983016171 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1124983016172 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1124983016173 active site 1124983016174 ATP-binding site [chemical binding]; other site 1124983016175 pantoate-binding site; other site 1124983016176 HXXH motif; other site 1124983016177 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 1124983016178 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1124983016179 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1124983016180 active site 1124983016181 dimer interface [polypeptide binding]; other site 1124983016182 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1124983016183 dimer interface [polypeptide binding]; other site 1124983016184 active site 1124983016185 acetyl-CoA synthetase; Provisional; Region: PRK00174 1124983016186 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1124983016187 active site 1124983016188 CoA binding site [chemical binding]; other site 1124983016189 acyl-activating enzyme (AAE) consensus motif; other site 1124983016190 AMP binding site [chemical binding]; other site 1124983016191 acetate binding site [chemical binding]; other site 1124983016192 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1124983016193 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1124983016194 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1124983016195 dimer interface [polypeptide binding]; other site 1124983016196 active site 1124983016197 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1124983016198 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1124983016199 putative RNA binding site [nucleotide binding]; other site 1124983016200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983016201 S-adenosylmethionine binding site [chemical binding]; other site 1124983016202 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1124983016203 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1124983016204 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1124983016205 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1124983016206 ligand binding site [chemical binding]; other site 1124983016207 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1124983016208 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1124983016209 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1124983016210 Pilin (bacterial filament); Region: Pilin; pfam00114 1124983016211 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1124983016212 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124983016213 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1124983016214 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1124983016215 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1124983016216 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1124983016217 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1124983016218 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1124983016219 CoA-binding site [chemical binding]; other site 1124983016220 ATP-binding [chemical binding]; other site 1124983016221 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1124983016222 Predicted membrane protein [Function unknown]; Region: COG3235 1124983016223 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 1124983016224 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1124983016225 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1124983016226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983016227 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1124983016228 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1124983016229 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983016230 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983016231 DNA binding residues [nucleotide binding] 1124983016232 dimerization interface [polypeptide binding]; other site 1124983016233 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1124983016234 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1124983016235 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 1124983016236 active site 1124983016237 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1124983016238 Clp amino terminal domain; Region: Clp_N; pfam02861 1124983016239 Clp amino terminal domain; Region: Clp_N; pfam02861 1124983016240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983016241 Walker A motif; other site 1124983016242 ATP binding site [chemical binding]; other site 1124983016243 Walker B motif; other site 1124983016244 arginine finger; other site 1124983016245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983016246 Walker A motif; other site 1124983016247 ATP binding site [chemical binding]; other site 1124983016248 Walker B motif; other site 1124983016249 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1124983016250 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1124983016251 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1124983016252 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1124983016253 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124983016254 RNA binding surface [nucleotide binding]; other site 1124983016255 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1124983016256 active site 1124983016257 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1124983016258 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 1124983016259 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1124983016260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983016261 active site 1124983016262 phosphorylation site [posttranslational modification] 1124983016263 intermolecular recognition site; other site 1124983016264 dimerization interface [polypeptide binding]; other site 1124983016265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983016266 Walker A motif; other site 1124983016267 ATP binding site [chemical binding]; other site 1124983016268 Walker B motif; other site 1124983016269 arginine finger; other site 1124983016270 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983016271 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1124983016272 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983016273 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1124983016274 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1124983016275 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1124983016276 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 1124983016277 PilX N-terminal; Region: PilX_N; pfam14341 1124983016278 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1124983016279 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1124983016280 Type II transport protein GspH; Region: GspH; pfam12019 1124983016281 Type II transport protein GspH; Region: GspH; pfam12019 1124983016282 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1124983016283 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1124983016284 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1124983016285 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124983016286 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1124983016287 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1124983016288 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1124983016289 active site 1124983016290 HIGH motif; other site 1124983016291 nucleotide binding site [chemical binding]; other site 1124983016292 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1124983016293 active site 1124983016294 KMSKS motif; other site 1124983016295 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1124983016296 tRNA binding surface [nucleotide binding]; other site 1124983016297 anticodon binding site; other site 1124983016298 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1124983016299 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1124983016300 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1124983016301 active site 1124983016302 Riboflavin kinase; Region: Flavokinase; smart00904 1124983016303 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1124983016304 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1124983016305 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1124983016306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 1124983016307 CreA protein; Region: CreA; pfam05981 1124983016308 gamma-glutamyl kinase; Provisional; Region: PRK05429 1124983016309 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1124983016310 nucleotide binding site [chemical binding]; other site 1124983016311 homotetrameric interface [polypeptide binding]; other site 1124983016312 putative phosphate binding site [ion binding]; other site 1124983016313 putative allosteric binding site; other site 1124983016314 PUA domain; Region: PUA; pfam01472 1124983016315 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1124983016316 GTP1/OBG; Region: GTP1_OBG; pfam01018 1124983016317 Obg GTPase; Region: Obg; cd01898 1124983016318 G1 box; other site 1124983016319 GTP/Mg2+ binding site [chemical binding]; other site 1124983016320 Switch I region; other site 1124983016321 G2 box; other site 1124983016322 G3 box; other site 1124983016323 Switch II region; other site 1124983016324 G4 box; other site 1124983016325 G5 box; other site 1124983016326 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1124983016327 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1124983016328 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1124983016329 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1124983016330 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1124983016331 substrate binding pocket [chemical binding]; other site 1124983016332 chain length determination region; other site 1124983016333 substrate-Mg2+ binding site; other site 1124983016334 catalytic residues [active] 1124983016335 aspartate-rich region 1; other site 1124983016336 active site lid residues [active] 1124983016337 aspartate-rich region 2; other site 1124983016338 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1124983016339 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1124983016340 PhnA protein; Region: PhnA; pfam03831 1124983016341 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1124983016342 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1124983016343 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124983016344 hypothetical protein; Provisional; Region: PRK05208 1124983016345 AAA domain; Region: AAA_32; pfam13654 1124983016346 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1124983016347 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1124983016348 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1124983016349 transcription elongation factor regulatory protein; Validated; Region: PRK06342 1124983016350 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124983016351 glutamate dehydrogenase; Provisional; Region: PRK09414 1124983016352 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1124983016353 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1124983016354 NAD(P) binding site [chemical binding]; other site 1124983016355 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1124983016356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983016357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983016358 ABC transporter; Region: ABC_tran_2; pfam12848 1124983016359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983016360 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1124983016361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983016362 putative active site [active] 1124983016363 heme pocket [chemical binding]; other site 1124983016364 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1124983016365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983016366 PAS domain; Region: PAS_9; pfam13426 1124983016367 putative active site [active] 1124983016368 heme pocket [chemical binding]; other site 1124983016369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983016370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983016371 metal binding site [ion binding]; metal-binding site 1124983016372 active site 1124983016373 I-site; other site 1124983016374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983016375 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1124983016376 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1124983016377 dimer interface [polypeptide binding]; other site 1124983016378 active site 1124983016379 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1124983016380 folate binding site [chemical binding]; other site 1124983016381 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 1124983016382 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124983016383 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1124983016384 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983016385 DNA-binding site [nucleotide binding]; DNA binding site 1124983016386 FCD domain; Region: FCD; pfam07729 1124983016387 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1124983016388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983016389 DNA-binding site [nucleotide binding]; DNA binding site 1124983016390 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1124983016391 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1124983016392 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1124983016393 P-loop, Walker A motif; other site 1124983016394 Base recognition motif; other site 1124983016395 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1124983016396 Uncharacterized small protein [Function unknown]; Region: COG2879 1124983016397 carbon starvation protein A; Provisional; Region: PRK15015 1124983016398 Carbon starvation protein CstA; Region: CstA; pfam02554 1124983016399 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1124983016400 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1124983016401 PilZ domain; Region: PilZ; pfam07238 1124983016402 DNA repair protein RadA; Provisional; Region: PRK11823 1124983016403 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124983016404 Walker A motif; other site 1124983016405 ATP binding site [chemical binding]; other site 1124983016406 Walker B motif; other site 1124983016407 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1124983016408 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1124983016409 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983016410 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1124983016411 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1124983016412 tetramer interface [polypeptide binding]; other site 1124983016413 heme binding pocket [chemical binding]; other site 1124983016414 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1124983016415 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1124983016416 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1124983016417 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1124983016418 FAD binding pocket [chemical binding]; other site 1124983016419 FAD binding motif [chemical binding]; other site 1124983016420 phosphate binding motif [ion binding]; other site 1124983016421 beta-alpha-beta structure motif; other site 1124983016422 NAD binding pocket [chemical binding]; other site 1124983016423 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1124983016424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983016425 S-adenosylmethionine binding site [chemical binding]; other site 1124983016426 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1124983016427 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1124983016428 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1124983016429 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1124983016430 H+ Antiporter protein; Region: 2A0121; TIGR00900 1124983016431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983016432 putative substrate translocation pore; other site 1124983016433 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 1124983016434 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1124983016435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983016436 sequence-specific DNA binding site [nucleotide binding]; other site 1124983016437 salt bridge; other site 1124983016438 DJ-1 family protein; Region: not_thiJ; TIGR01383 1124983016439 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1124983016440 conserved cys residue [active] 1124983016441 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1124983016442 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1124983016443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983016444 S-adenosylmethionine binding site [chemical binding]; other site 1124983016445 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1124983016446 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1124983016447 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983016448 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983016449 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1124983016450 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1124983016451 Walker A/P-loop; other site 1124983016452 ATP binding site [chemical binding]; other site 1124983016453 Q-loop/lid; other site 1124983016454 ABC transporter signature motif; other site 1124983016455 Walker B; other site 1124983016456 D-loop; other site 1124983016457 H-loop/switch region; other site 1124983016458 Heme-binding protein A (HasA); Region: HasA; pfam06438 1124983016459 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983016460 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1124983016461 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983016462 N-terminal plug; other site 1124983016463 ligand-binding site [chemical binding]; other site 1124983016464 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983016465 FecR protein; Region: FecR; pfam04773 1124983016466 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1124983016467 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983016468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983016469 DNA binding residues [nucleotide binding] 1124983016470 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1124983016471 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1124983016472 active site 1124983016473 trimer interface [polypeptide binding]; other site 1124983016474 dimer interface [polypeptide binding]; other site 1124983016475 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1124983016476 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1124983016477 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1124983016478 shikimate binding site; other site 1124983016479 NAD(P) binding site [chemical binding]; other site 1124983016480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983016481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983016482 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1124983016483 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1124983016484 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1124983016485 dimer interface [polypeptide binding]; other site 1124983016486 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1124983016487 active site 1124983016488 Fe binding site [ion binding]; other site 1124983016489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983016490 D-galactonate transporter; Region: 2A0114; TIGR00893 1124983016491 putative substrate translocation pore; other site 1124983016492 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1124983016493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983016494 dimerization interface [polypeptide binding]; other site 1124983016495 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983016496 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983016497 dimer interface [polypeptide binding]; other site 1124983016498 putative CheW interface [polypeptide binding]; other site 1124983016499 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1124983016500 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1124983016501 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1124983016502 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1124983016503 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1124983016504 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1124983016505 Bacterial transcriptional regulator; Region: IclR; pfam01614 1124983016506 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1124983016507 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1124983016508 active site 1124983016509 catalytic tetrad [active] 1124983016510 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1124983016511 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1124983016512 heterodimer interface [polypeptide binding]; other site 1124983016513 active site 1124983016514 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1124983016515 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1124983016516 active site 1124983016517 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1124983016518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983016519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983016520 dimerization interface [polypeptide binding]; other site 1124983016521 Predicted metalloprotease [General function prediction only]; Region: COG2321 1124983016522 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1124983016523 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1124983016524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983016525 active site 1124983016526 motif I; other site 1124983016527 motif II; other site 1124983016528 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1124983016529 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1124983016530 active site 1124983016531 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1124983016532 catalytic triad [active] 1124983016533 dimer interface [polypeptide binding]; other site 1124983016534 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1124983016535 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983016536 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1124983016537 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1124983016538 putative active site [active] 1124983016539 Zn binding site [ion binding]; other site 1124983016540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1124983016541 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1124983016542 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124983016543 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1124983016544 ATP binding site [chemical binding]; other site 1124983016545 Mg++ binding site [ion binding]; other site 1124983016546 motif III; other site 1124983016547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983016548 nucleotide binding region [chemical binding]; other site 1124983016549 ATP-binding site [chemical binding]; other site 1124983016550 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1124983016551 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124983016552 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1124983016553 EamA-like transporter family; Region: EamA; pfam00892 1124983016554 EamA-like transporter family; Region: EamA; pfam00892 1124983016555 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983016556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983016557 putative DNA binding site [nucleotide binding]; other site 1124983016558 putative Zn2+ binding site [ion binding]; other site 1124983016559 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983016560 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1124983016561 active site 1124983016562 catalytic site [active] 1124983016563 substrate binding site [chemical binding]; other site 1124983016564 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1124983016565 LabA_like proteins; Region: LabA; cd10911 1124983016566 putative metal binding site [ion binding]; other site 1124983016567 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1124983016568 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1124983016569 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 1124983016570 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1124983016571 putative catalytic site [active] 1124983016572 putative metal binding site [ion binding]; other site 1124983016573 putative phosphate binding site [ion binding]; other site 1124983016574 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1124983016575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983016576 ATP binding site [chemical binding]; other site 1124983016577 putative Mg++ binding site [ion binding]; other site 1124983016578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983016579 nucleotide binding region [chemical binding]; other site 1124983016580 ATP-binding site [chemical binding]; other site 1124983016581 Helicase associated domain (HA2); Region: HA2; pfam04408 1124983016582 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1124983016583 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1124983016584 Cation efflux family; Region: Cation_efflux; cl00316 1124983016585 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983016586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983016587 putative DNA binding site [nucleotide binding]; other site 1124983016588 putative Zn2+ binding site [ion binding]; other site 1124983016589 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983016590 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1124983016591 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1124983016592 pseudouridine synthase; Region: TIGR00093 1124983016593 active site 1124983016594 AMP nucleosidase; Provisional; Region: PRK08292 1124983016595 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1124983016596 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1124983016597 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1124983016598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983016599 active site 1124983016600 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1124983016601 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1124983016602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1124983016603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983016604 dimer interface [polypeptide binding]; other site 1124983016605 phosphorylation site [posttranslational modification] 1124983016606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983016607 ATP binding site [chemical binding]; other site 1124983016608 Mg2+ binding site [ion binding]; other site 1124983016609 G-X-G motif; other site 1124983016610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983016611 active site 1124983016612 phosphorylation site [posttranslational modification] 1124983016613 dimerization interface [polypeptide binding]; other site 1124983016614 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1124983016615 dimer interface [polypeptide binding]; other site 1124983016616 substrate binding site [chemical binding]; other site 1124983016617 ATP binding site [chemical binding]; other site 1124983016618 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1124983016619 thiamine phosphate binding site [chemical binding]; other site 1124983016620 active site 1124983016621 pyrophosphate binding site [ion binding]; other site 1124983016622 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1124983016623 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983016624 inhibitor-cofactor binding pocket; inhibition site 1124983016625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983016626 catalytic residue [active] 1124983016627 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1124983016628 Sel1-like repeats; Region: SEL1; smart00671 1124983016629 Sel1-like repeats; Region: SEL1; smart00671 1124983016630 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1124983016631 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1124983016632 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1124983016633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983016634 FeS/SAM binding site; other site 1124983016635 TRAM domain; Region: TRAM; pfam01938 1124983016636 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1124983016637 PhoH-like protein; Region: PhoH; pfam02562 1124983016638 metal-binding heat shock protein; Provisional; Region: PRK00016 1124983016639 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1124983016640 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124983016641 Transporter associated domain; Region: CorC_HlyC; smart01091 1124983016642 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1124983016643 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1124983016644 putative active site [active] 1124983016645 catalytic triad [active] 1124983016646 putative dimer interface [polypeptide binding]; other site 1124983016647 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1124983016648 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1124983016649 putative active site [active] 1124983016650 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1124983016651 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1124983016652 HIGH motif; other site 1124983016653 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1124983016654 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1124983016655 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1124983016656 active site 1124983016657 KMSKS motif; other site 1124983016658 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1124983016659 tRNA binding surface [nucleotide binding]; other site 1124983016660 Lipopolysaccharide-assembly; Region: LptE; cl01125 1124983016661 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1124983016662 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1124983016663 Domain of unknown function; Region: DUF331; cl01149 1124983016664 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1124983016665 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124983016666 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124983016667 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1124983016668 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1124983016669 dimer interface [polypeptide binding]; other site 1124983016670 catalytic triad [active] 1124983016671 lipoyl synthase; Provisional; Region: PRK05481 1124983016672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983016673 FeS/SAM binding site; other site 1124983016674 lipoate-protein ligase B; Provisional; Region: PRK14342 1124983016675 hypothetical protein; Provisional; Region: PRK00341 1124983016676 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1124983016677 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1124983016678 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1124983016679 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1124983016680 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1124983016681 Sporulation related domain; Region: SPOR; pfam05036 1124983016682 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1124983016683 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1124983016684 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1124983016685 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1124983016686 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1124983016687 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1124983016688 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1124983016689 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1124983016690 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1124983016691 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1124983016692 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1124983016693 active site 1124983016694 (T/H)XGH motif; other site 1124983016695 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1124983016696 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1124983016697 putative catalytic cysteine [active] 1124983016698 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1124983016699 active site 1124983016700 DNA binding site [nucleotide binding] 1124983016701 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124983016702 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1124983016703 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1124983016704 active site 1124983016705 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1124983016706 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1124983016707 LrgA family; Region: LrgA; cl00608 1124983016708 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1124983016709 putative active site [active] 1124983016710 putative catalytic site [active] 1124983016711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1124983016712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1124983016713 Peptidase C13 family; Region: Peptidase_C13; pfam01650 1124983016714 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1124983016715 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1124983016716 NAD binding site [chemical binding]; other site 1124983016717 active site 1124983016718 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1124983016719 aromatic acid decarboxylase; Validated; Region: PRK05920 1124983016720 Flavoprotein; Region: Flavoprotein; pfam02441 1124983016721 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1124983016722 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1124983016723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1124983016724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1124983016725 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1124983016726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1124983016727 putative active site [active] 1124983016728 heme pocket [chemical binding]; other site 1124983016729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983016730 Walker A motif; other site 1124983016731 ATP binding site [chemical binding]; other site 1124983016732 Walker B motif; other site 1124983016733 arginine finger; other site 1124983016734 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1124983016735 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1124983016736 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1124983016737 NAD(P) binding site [chemical binding]; other site 1124983016738 catalytic residues [active] 1124983016739 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 1124983016740 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1124983016741 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1124983016742 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1124983016743 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 1124983016744 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1124983016745 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1124983016746 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1124983016747 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1124983016748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983016749 Coenzyme A binding pocket [chemical binding]; other site 1124983016750 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1124983016751 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124983016752 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1124983016753 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1124983016754 dimer interface [polypeptide binding]; other site 1124983016755 substrate binding site [chemical binding]; other site 1124983016756 metal binding sites [ion binding]; metal-binding site 1124983016757 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983016758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983016759 I-site; other site 1124983016760 active site 1124983016761 metal binding site [ion binding]; metal-binding site 1124983016762 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1124983016763 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1124983016764 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1124983016765 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1124983016766 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1124983016767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1124983016768 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1124983016769 Predicted secreted protein [Function unknown]; Region: COG5445 1124983016770 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1124983016771 Predicted secreted protein [Function unknown]; Region: COG5445 1124983016772 Stage II sporulation protein; Region: SpoIID; pfam08486 1124983016773 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1124983016774 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1124983016775 MG2 domain; Region: A2M_N; pfam01835 1124983016776 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1124983016777 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1124983016778 surface patch; other site 1124983016779 thioester region; other site 1124983016780 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 1124983016781 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909 1124983016782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1124983016783 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1124983016784 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1124983016785 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1124983016786 substrate binding pocket [chemical binding]; other site 1124983016787 chain length determination region; other site 1124983016788 substrate-Mg2+ binding site; other site 1124983016789 catalytic residues [active] 1124983016790 aspartate-rich region 1; other site 1124983016791 active site lid residues [active] 1124983016792 aspartate-rich region 2; other site 1124983016793 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1124983016794 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1124983016795 TPP-binding site; other site 1124983016796 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1124983016797 PYR/PP interface [polypeptide binding]; other site 1124983016798 dimer interface [polypeptide binding]; other site 1124983016799 TPP binding site [chemical binding]; other site 1124983016800 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1124983016801 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1124983016802 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983016803 N-terminal plug; other site 1124983016804 ligand-binding site [chemical binding]; other site 1124983016805 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1124983016806 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1124983016807 cobalamin binding residues [chemical binding]; other site 1124983016808 putative BtuC binding residues; other site 1124983016809 dimer interface [polypeptide binding]; other site 1124983016810 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1124983016811 dimerization interface [polypeptide binding]; other site 1124983016812 active site 1124983016813 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1124983016814 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1124983016815 tetramer interfaces [polypeptide binding]; other site 1124983016816 binuclear metal-binding site [ion binding]; other site 1124983016817 thiamine monophosphate kinase; Provisional; Region: PRK05731 1124983016818 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1124983016819 ATP binding site [chemical binding]; other site 1124983016820 dimerization interface [polypeptide binding]; other site 1124983016821 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1124983016822 putative RNA binding site [nucleotide binding]; other site 1124983016823 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1124983016824 homopentamer interface [polypeptide binding]; other site 1124983016825 active site 1124983016826 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1124983016827 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1124983016828 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1124983016829 dimerization interface [polypeptide binding]; other site 1124983016830 active site 1124983016831 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1124983016832 Lumazine binding domain; Region: Lum_binding; pfam00677 1124983016833 Lumazine binding domain; Region: Lum_binding; pfam00677 1124983016834 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1124983016835 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1124983016836 catalytic motif [active] 1124983016837 Zn binding site [ion binding]; other site 1124983016838 RibD C-terminal domain; Region: RibD_C; cl17279 1124983016839 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1124983016840 ATP cone domain; Region: ATP-cone; pfam03477 1124983016841 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1124983016842 Predicted methyltransferase [General function prediction only]; Region: COG3897 1124983016843 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1124983016844 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1124983016845 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1124983016846 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1124983016847 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1124983016848 Walker A/P-loop; other site 1124983016849 ATP binding site [chemical binding]; other site 1124983016850 Q-loop/lid; other site 1124983016851 ABC transporter signature motif; other site 1124983016852 Walker B; other site 1124983016853 D-loop; other site 1124983016854 H-loop/switch region; other site 1124983016855 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1124983016856 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1124983016857 FtsX-like permease family; Region: FtsX; pfam02687 1124983016858 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1124983016859 OmpW family; Region: OmpW; cl17427 1124983016860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983016861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983016862 NAD(P) binding site [chemical binding]; other site 1124983016863 active site 1124983016864 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1124983016865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983016866 ATP binding site [chemical binding]; other site 1124983016867 putative Mg++ binding site [ion binding]; other site 1124983016868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983016869 nucleotide binding region [chemical binding]; other site 1124983016870 ATP-binding site [chemical binding]; other site 1124983016871 DEAD/H associated; Region: DEAD_assoc; pfam08494 1124983016872 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1124983016873 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124983016874 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1124983016875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983016876 putative substrate translocation pore; other site 1124983016877 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1124983016878 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1124983016879 conserved cys residue [active] 1124983016880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983016881 Isochorismatase family; Region: Isochorismatase; pfam00857 1124983016882 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1124983016883 catalytic triad [active] 1124983016884 conserved cis-peptide bond; other site 1124983016885 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1124983016886 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 1124983016887 active site 1124983016888 metal binding site [ion binding]; metal-binding site 1124983016889 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1124983016890 TatD related DNase; Region: TatD_DNase; pfam01026 1124983016891 active site 1124983016892 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1124983016893 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1124983016894 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1124983016895 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1124983016896 dimer interface [polypeptide binding]; other site 1124983016897 ssDNA binding site [nucleotide binding]; other site 1124983016898 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1124983016899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983016900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983016901 putative substrate translocation pore; other site 1124983016902 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1124983016903 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1124983016904 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1124983016905 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1124983016906 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1124983016907 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1124983016908 heme binding site [chemical binding]; other site 1124983016909 ferroxidase pore; other site 1124983016910 ferroxidase diiron center [ion binding]; other site 1124983016911 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1124983016912 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1124983016913 tetramer interface [polypeptide binding]; other site 1124983016914 heme binding pocket [chemical binding]; other site 1124983016915 NADPH binding site [chemical binding]; other site 1124983016916 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1124983016917 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1124983016918 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1124983016919 alphaNTD homodimer interface [polypeptide binding]; other site 1124983016920 alphaNTD - beta interaction site [polypeptide binding]; other site 1124983016921 alphaNTD - beta' interaction site [polypeptide binding]; other site 1124983016922 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1124983016923 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1124983016924 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1124983016925 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1124983016926 RNA binding surface [nucleotide binding]; other site 1124983016927 30S ribosomal protein S11; Validated; Region: PRK05309 1124983016928 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1124983016929 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1124983016930 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1124983016931 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1124983016932 SecY translocase; Region: SecY; pfam00344 1124983016933 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1124983016934 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1124983016935 23S rRNA binding site [nucleotide binding]; other site 1124983016936 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1124983016937 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1124983016938 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1124983016939 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1124983016940 5S rRNA interface [nucleotide binding]; other site 1124983016941 23S rRNA interface [nucleotide binding]; other site 1124983016942 L5 interface [polypeptide binding]; other site 1124983016943 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1124983016944 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1124983016945 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1124983016946 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1124983016947 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1124983016948 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1124983016949 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1124983016950 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1124983016951 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1124983016952 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1124983016953 RNA binding site [nucleotide binding]; other site 1124983016954 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1124983016955 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1124983016956 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1124983016957 23S rRNA interface [nucleotide binding]; other site 1124983016958 putative translocon interaction site; other site 1124983016959 signal recognition particle (SRP54) interaction site; other site 1124983016960 L23 interface [polypeptide binding]; other site 1124983016961 trigger factor interaction site; other site 1124983016962 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1124983016963 23S rRNA interface [nucleotide binding]; other site 1124983016964 5S rRNA interface [nucleotide binding]; other site 1124983016965 putative antibiotic binding site [chemical binding]; other site 1124983016966 L25 interface [polypeptide binding]; other site 1124983016967 L27 interface [polypeptide binding]; other site 1124983016968 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1124983016969 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1124983016970 G-X-X-G motif; other site 1124983016971 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1124983016972 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1124983016973 protein-rRNA interface [nucleotide binding]; other site 1124983016974 putative translocon binding site; other site 1124983016975 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1124983016976 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1124983016977 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1124983016978 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1124983016979 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1124983016980 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1124983016981 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1124983016982 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1124983016983 elongation factor Tu; Reviewed; Region: PRK00049 1124983016984 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1124983016985 G1 box; other site 1124983016986 GEF interaction site [polypeptide binding]; other site 1124983016987 GTP/Mg2+ binding site [chemical binding]; other site 1124983016988 Switch I region; other site 1124983016989 G2 box; other site 1124983016990 G3 box; other site 1124983016991 Switch II region; other site 1124983016992 G4 box; other site 1124983016993 G5 box; other site 1124983016994 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1124983016995 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1124983016996 Antibiotic Binding Site [chemical binding]; other site 1124983016997 elongation factor G; Reviewed; Region: PRK00007 1124983016998 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1124983016999 G1 box; other site 1124983017000 putative GEF interaction site [polypeptide binding]; other site 1124983017001 GTP/Mg2+ binding site [chemical binding]; other site 1124983017002 Switch I region; other site 1124983017003 G2 box; other site 1124983017004 G3 box; other site 1124983017005 Switch II region; other site 1124983017006 G4 box; other site 1124983017007 G5 box; other site 1124983017008 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1124983017009 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1124983017010 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1124983017011 30S ribosomal protein S7; Validated; Region: PRK05302 1124983017012 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1124983017013 S17 interaction site [polypeptide binding]; other site 1124983017014 S8 interaction site; other site 1124983017015 16S rRNA interaction site [nucleotide binding]; other site 1124983017016 streptomycin interaction site [chemical binding]; other site 1124983017017 23S rRNA interaction site [nucleotide binding]; other site 1124983017018 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1124983017019 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1124983017020 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1124983017021 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1124983017022 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1124983017023 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1124983017024 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1124983017025 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1124983017026 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1124983017027 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1124983017028 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1124983017029 DNA binding site [nucleotide binding] 1124983017030 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1124983017031 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1124983017032 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1124983017033 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1124983017034 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1124983017035 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1124983017036 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1124983017037 RPB3 interaction site [polypeptide binding]; other site 1124983017038 RPB1 interaction site [polypeptide binding]; other site 1124983017039 RPB11 interaction site [polypeptide binding]; other site 1124983017040 RPB10 interaction site [polypeptide binding]; other site 1124983017041 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1124983017042 core dimer interface [polypeptide binding]; other site 1124983017043 peripheral dimer interface [polypeptide binding]; other site 1124983017044 L10 interface [polypeptide binding]; other site 1124983017045 L11 interface [polypeptide binding]; other site 1124983017046 putative EF-Tu interaction site [polypeptide binding]; other site 1124983017047 putative EF-G interaction site [polypeptide binding]; other site 1124983017048 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1124983017049 23S rRNA interface [nucleotide binding]; other site 1124983017050 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1124983017051 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1124983017052 mRNA/rRNA interface [nucleotide binding]; other site 1124983017053 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1124983017054 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1124983017055 23S rRNA interface [nucleotide binding]; other site 1124983017056 L7/L12 interface [polypeptide binding]; other site 1124983017057 putative thiostrepton binding site; other site 1124983017058 L25 interface [polypeptide binding]; other site 1124983017059 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1124983017060 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1124983017061 putative homodimer interface [polypeptide binding]; other site 1124983017062 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1124983017063 heterodimer interface [polypeptide binding]; other site 1124983017064 homodimer interface [polypeptide binding]; other site 1124983017065 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1124983017066 elongation factor Tu; Reviewed; Region: PRK00049 1124983017067 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1124983017068 G1 box; other site 1124983017069 GEF interaction site [polypeptide binding]; other site 1124983017070 GTP/Mg2+ binding site [chemical binding]; other site 1124983017071 Switch I region; other site 1124983017072 G2 box; other site 1124983017073 G3 box; other site 1124983017074 Switch II region; other site 1124983017075 G4 box; other site 1124983017076 G5 box; other site 1124983017077 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1124983017078 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1124983017079 Antibiotic Binding Site [chemical binding]; other site 1124983017080 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1124983017081 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1124983017082 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1124983017083 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1124983017084 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1124983017085 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1124983017086 active site 1124983017087 HIGH motif; other site 1124983017088 dimer interface [polypeptide binding]; other site 1124983017089 KMSKS motif; other site 1124983017090 putative peptidase; Provisional; Region: PRK11649 1124983017091 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1124983017092 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124983017093 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1124983017094 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1124983017095 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1124983017096 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1124983017097 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1124983017098 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1124983017099 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1124983017100 FMN binding site [chemical binding]; other site 1124983017101 substrate binding site [chemical binding]; other site 1124983017102 putative catalytic residue [active] 1124983017103 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1124983017104 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1124983017105 classical (c) SDRs; Region: SDR_c; cd05233 1124983017106 NAD(P) binding site [chemical binding]; other site 1124983017107 active site 1124983017108 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1124983017109 nucleotide binding site/active site [active] 1124983017110 HIT family signature motif; other site 1124983017111 catalytic residue [active] 1124983017112 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1124983017113 diiron binding motif [ion binding]; other site 1124983017114 OsmC-like protein; Region: OsmC; cl00767 1124983017115 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1124983017116 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124983017117 ligand binding site [chemical binding]; other site 1124983017118 flexible hinge region; other site 1124983017119 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1124983017120 putative switch regulator; other site 1124983017121 non-specific DNA interactions [nucleotide binding]; other site 1124983017122 DNA binding site [nucleotide binding] 1124983017123 sequence specific DNA binding site [nucleotide binding]; other site 1124983017124 putative cAMP binding site [chemical binding]; other site 1124983017125 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1124983017126 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1124983017127 active site 1124983017128 ribulose/triose binding site [chemical binding]; other site 1124983017129 phosphate binding site [ion binding]; other site 1124983017130 substrate (anthranilate) binding pocket [chemical binding]; other site 1124983017131 product (indole) binding pocket [chemical binding]; other site 1124983017132 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1124983017133 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1124983017134 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1124983017135 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1124983017136 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1124983017137 glutamine binding [chemical binding]; other site 1124983017138 catalytic triad [active] 1124983017139 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1124983017140 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983017141 Walker A/P-loop; other site 1124983017142 ATP binding site [chemical binding]; other site 1124983017143 Q-loop/lid; other site 1124983017144 ABC transporter signature motif; other site 1124983017145 Walker B; other site 1124983017146 D-loop; other site 1124983017147 H-loop/switch region; other site 1124983017148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1124983017149 Walker A/P-loop; other site 1124983017150 ATP binding site [chemical binding]; other site 1124983017151 Q-loop/lid; other site 1124983017152 ABC transporter signature motif; other site 1124983017153 Walker B; other site 1124983017154 D-loop; other site 1124983017155 H-loop/switch region; other site 1124983017156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1124983017157 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1124983017158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983017159 dimer interface [polypeptide binding]; other site 1124983017160 conserved gate region; other site 1124983017161 putative PBP binding loops; other site 1124983017162 ABC-ATPase subunit interface; other site 1124983017163 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1124983017164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983017165 dimer interface [polypeptide binding]; other site 1124983017166 conserved gate region; other site 1124983017167 ABC-ATPase subunit interface; other site 1124983017168 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1124983017169 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1124983017170 Rrf2 family protein; Region: rrf2_super; TIGR00738 1124983017171 Transcriptional regulator; Region: Rrf2; pfam02082 1124983017172 anthranilate synthase component I; Provisional; Region: PRK13565 1124983017173 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1124983017174 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1124983017175 phosphoglycolate phosphatase; Provisional; Region: PRK13223 1124983017176 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1124983017177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983017178 motif II; other site 1124983017179 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1124983017180 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1124983017181 substrate binding site [chemical binding]; other site 1124983017182 hexamer interface [polypeptide binding]; other site 1124983017183 metal binding site [ion binding]; metal-binding site 1124983017184 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1124983017185 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1124983017186 active site 1124983017187 NAD binding site [chemical binding]; other site 1124983017188 metal binding site [ion binding]; metal-binding site 1124983017189 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1124983017190 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1124983017191 active site 1124983017192 NAD binding site [chemical binding]; other site 1124983017193 metal binding site [ion binding]; metal-binding site 1124983017194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983017195 PAS domain; Region: PAS_9; pfam13426 1124983017196 putative active site [active] 1124983017197 heme pocket [chemical binding]; other site 1124983017198 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1124983017199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983017200 Walker A motif; other site 1124983017201 ATP binding site [chemical binding]; other site 1124983017202 Walker B motif; other site 1124983017203 arginine finger; other site 1124983017204 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1124983017205 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124983017206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983017207 dimer interface [polypeptide binding]; other site 1124983017208 conserved gate region; other site 1124983017209 putative PBP binding loops; other site 1124983017210 ABC-ATPase subunit interface; other site 1124983017211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983017212 dimer interface [polypeptide binding]; other site 1124983017213 conserved gate region; other site 1124983017214 putative PBP binding loops; other site 1124983017215 ABC-ATPase subunit interface; other site 1124983017216 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1124983017217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983017218 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1124983017219 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1124983017220 Walker A/P-loop; other site 1124983017221 ATP binding site [chemical binding]; other site 1124983017222 Q-loop/lid; other site 1124983017223 ABC transporter signature motif; other site 1124983017224 Walker B; other site 1124983017225 D-loop; other site 1124983017226 H-loop/switch region; other site 1124983017227 TOBE domain; Region: TOBE_2; pfam08402 1124983017228 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1124983017229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983017230 active site 1124983017231 phosphorylation site [posttranslational modification] 1124983017232 intermolecular recognition site; other site 1124983017233 dimerization interface [polypeptide binding]; other site 1124983017234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1124983017235 DNA binding residues [nucleotide binding] 1124983017236 dimerization interface [polypeptide binding]; other site 1124983017237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983017238 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983017239 substrate binding pocket [chemical binding]; other site 1124983017240 membrane-bound complex binding site; other site 1124983017241 hinge residues; other site 1124983017242 PAS domain; Region: PAS_9; pfam13426 1124983017243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983017244 putative active site [active] 1124983017245 heme pocket [chemical binding]; other site 1124983017246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983017247 PAS fold; Region: PAS_3; pfam08447 1124983017248 putative active site [active] 1124983017249 heme pocket [chemical binding]; other site 1124983017250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1124983017251 Histidine kinase; Region: HisKA_3; pfam07730 1124983017252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983017253 ATP binding site [chemical binding]; other site 1124983017254 Mg2+ binding site [ion binding]; other site 1124983017255 G-X-G motif; other site 1124983017256 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1124983017257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983017258 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1124983017259 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1124983017260 putative metal binding site [ion binding]; other site 1124983017261 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1124983017262 HSP70 interaction site [polypeptide binding]; other site 1124983017263 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1124983017264 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1124983017265 Substrate binding site; other site 1124983017266 metal-binding site 1124983017267 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1124983017268 Phosphotransferase enzyme family; Region: APH; pfam01636 1124983017269 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1124983017270 OstA-like protein; Region: OstA; cl00844 1124983017271 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1124983017272 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1124983017273 SurA N-terminal domain; Region: SurA_N; pfam09312 1124983017274 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1124983017275 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1124983017276 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1124983017277 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1124983017278 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1124983017279 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1124983017280 S-adenosylmethionine binding site [chemical binding]; other site 1124983017281 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1124983017282 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1124983017283 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1124983017284 active site 1124983017285 metal binding site [ion binding]; metal-binding site 1124983017286 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1124983017287 active site residue [active] 1124983017288 PrkA family serine protein kinase; Provisional; Region: PRK15455 1124983017289 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1124983017290 hypothetical protein; Provisional; Region: PRK05325 1124983017291 SpoVR family protein; Provisional; Region: PRK11767 1124983017292 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1124983017293 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1124983017294 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1124983017295 active site 1124983017296 NTP binding site [chemical binding]; other site 1124983017297 metal binding triad [ion binding]; metal-binding site 1124983017298 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1124983017299 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983017300 Zn2+ binding site [ion binding]; other site 1124983017301 Mg2+ binding site [ion binding]; other site 1124983017302 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1124983017303 catalytic center binding site [active] 1124983017304 ATP binding site [chemical binding]; other site 1124983017305 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1124983017306 homooctamer interface [polypeptide binding]; other site 1124983017307 active site 1124983017308 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1124983017309 UGMP family protein; Validated; Region: PRK09604 1124983017310 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1124983017311 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1124983017312 DNA primase, catalytic core; Region: dnaG; TIGR01391 1124983017313 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1124983017314 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1124983017315 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1124983017316 active site 1124983017317 metal binding site [ion binding]; metal-binding site 1124983017318 interdomain interaction site; other site 1124983017319 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1124983017320 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1124983017321 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1124983017322 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1124983017323 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1124983017324 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1124983017325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983017326 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1124983017327 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983017328 DNA binding residues [nucleotide binding] 1124983017329 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983017330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983017331 substrate binding pocket [chemical binding]; other site 1124983017332 membrane-bound complex binding site; other site 1124983017333 hinge residues; other site 1124983017334 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1124983017335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983017336 putative active site [active] 1124983017337 heme pocket [chemical binding]; other site 1124983017338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983017339 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1124983017340 putative active site [active] 1124983017341 heme pocket [chemical binding]; other site 1124983017342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983017343 putative active site [active] 1124983017344 heme pocket [chemical binding]; other site 1124983017345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983017346 putative active site [active] 1124983017347 heme pocket [chemical binding]; other site 1124983017348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983017349 metal binding site [ion binding]; metal-binding site 1124983017350 active site 1124983017351 I-site; other site 1124983017352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983017353 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1124983017354 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1124983017355 Trp docking motif [polypeptide binding]; other site 1124983017356 putative active site [active] 1124983017357 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983017358 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1124983017359 putative DNA binding site [nucleotide binding]; other site 1124983017360 putative Zn2+ binding site [ion binding]; other site 1124983017361 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983017362 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1124983017363 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124983017364 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1124983017365 putative active site [active] 1124983017366 catalytic triad [active] 1124983017367 putative dimer interface [polypeptide binding]; other site 1124983017368 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1124983017369 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1124983017370 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1124983017371 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1124983017372 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1124983017373 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1124983017374 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1124983017375 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1124983017376 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1124983017377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983017378 FeS/SAM binding site; other site 1124983017379 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1124983017380 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1124983017381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1124983017382 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1124983017383 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1124983017384 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1124983017385 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1124983017386 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983017387 inhibitor-cofactor binding pocket; inhibition site 1124983017388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983017389 catalytic residue [active] 1124983017390 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1124983017391 MOSC domain; Region: MOSC; pfam03473 1124983017392 3-alpha domain; Region: 3-alpha; pfam03475 1124983017393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983017394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983017395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983017396 dimerization interface [polypeptide binding]; other site 1124983017397 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1124983017398 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1124983017399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983017400 active site 1124983017401 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1124983017402 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1124983017403 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1124983017404 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1124983017405 FAD binding site [chemical binding]; other site 1124983017406 substrate binding site [chemical binding]; other site 1124983017407 catalytic residues [active] 1124983017408 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1124983017409 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983017410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983017411 metal binding site [ion binding]; metal-binding site 1124983017412 active site 1124983017413 I-site; other site 1124983017414 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1124983017415 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1124983017416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1124983017417 active site 1124983017418 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1124983017419 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1124983017420 AAA domain; Region: AAA_26; pfam13500 1124983017421 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1124983017422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983017423 S-adenosylmethionine binding site [chemical binding]; other site 1124983017424 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1124983017425 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1124983017426 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1124983017427 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1124983017428 substrate-cofactor binding pocket; other site 1124983017429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983017430 catalytic residue [active] 1124983017431 biotin synthase; Provisional; Region: PRK15108 1124983017432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983017433 FeS/SAM binding site; other site 1124983017434 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1124983017435 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1124983017436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983017437 active site 1124983017438 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1124983017439 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1124983017440 TOBE domain; Region: TOBE; cl01440 1124983017441 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1124983017442 serine/threonine protein kinase; Provisional; Region: PRK11768 1124983017443 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1124983017444 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1124983017445 EamA-like transporter family; Region: EamA; pfam00892 1124983017446 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1124983017447 ACT domain; Region: ACT_6; pfam13740 1124983017448 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1124983017449 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1124983017450 active site 1124983017451 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983017452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983017453 active site 1124983017454 phosphorylation site [posttranslational modification] 1124983017455 intermolecular recognition site; other site 1124983017456 dimerization interface [polypeptide binding]; other site 1124983017457 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1124983017458 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1124983017459 ligand binding site [chemical binding]; other site 1124983017460 flexible hinge region; other site 1124983017461 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1124983017462 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1124983017463 metal binding triad; other site 1124983017464 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1124983017465 active site 1124983017466 catalytic site [active] 1124983017467 substrate binding site [chemical binding]; other site 1124983017468 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1124983017469 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983017470 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983017471 DNA binding residues [nucleotide binding] 1124983017472 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1124983017473 FecR protein; Region: FecR; pfam04773 1124983017474 Secretin and TonB N terminus short domain; Region: STN; smart00965 1124983017475 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1124983017476 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1124983017477 N-terminal plug; other site 1124983017478 ligand-binding site [chemical binding]; other site 1124983017479 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1124983017480 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1124983017481 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1124983017482 putative glutathione S-transferase; Provisional; Region: PRK10357 1124983017483 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1124983017484 putative C-terminal domain interface [polypeptide binding]; other site 1124983017485 putative GSH binding site (G-site) [chemical binding]; other site 1124983017486 putative dimer interface [polypeptide binding]; other site 1124983017487 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1124983017488 N-terminal domain interface [polypeptide binding]; other site 1124983017489 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983017490 dimer interface [polypeptide binding]; other site 1124983017491 inner membrane protein; Provisional; Region: PRK11715 1124983017492 sensory histidine kinase CreC; Provisional; Region: PRK11100 1124983017493 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1124983017494 dimerization interface [polypeptide binding]; other site 1124983017495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983017496 dimer interface [polypeptide binding]; other site 1124983017497 phosphorylation site [posttranslational modification] 1124983017498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983017499 ATP binding site [chemical binding]; other site 1124983017500 Mg2+ binding site [ion binding]; other site 1124983017501 G-X-G motif; other site 1124983017502 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1124983017503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983017504 active site 1124983017505 phosphorylation site [posttranslational modification] 1124983017506 intermolecular recognition site; other site 1124983017507 dimerization interface [polypeptide binding]; other site 1124983017508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983017509 DNA binding site [nucleotide binding] 1124983017510 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1124983017511 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124983017512 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1124983017513 putative acyl-acceptor binding pocket; other site 1124983017514 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1124983017515 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1124983017516 Predicted membrane protein [Function unknown]; Region: COG3766 1124983017517 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1124983017518 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1124983017519 RNA polymerase sigma factor; Provisional; Region: PRK12514 1124983017520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983017521 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983017522 DNA binding residues [nucleotide binding] 1124983017523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1124983017524 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1124983017525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1124983017526 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 1124983017527 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1124983017528 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1124983017529 NAD binding site [chemical binding]; other site 1124983017530 catalytic Zn binding site [ion binding]; other site 1124983017531 structural Zn binding site [ion binding]; other site 1124983017532 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1124983017533 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1124983017534 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1124983017535 putative active site [active] 1124983017536 putative substrate binding site [chemical binding]; other site 1124983017537 putative cosubstrate binding site; other site 1124983017538 catalytic site [active] 1124983017539 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 1124983017540 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1124983017541 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1124983017542 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1124983017543 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1124983017544 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1124983017545 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983017546 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 1124983017547 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1124983017548 dimer interface [polypeptide binding]; other site 1124983017549 active site 1124983017550 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1124983017551 folate binding site [chemical binding]; other site 1124983017552 TraX protein; Region: TraX; cl05434 1124983017553 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1124983017554 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1124983017555 tetramer interface [polypeptide binding]; other site 1124983017556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983017557 catalytic residue [active] 1124983017558 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1124983017559 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1124983017560 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1124983017561 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1124983017562 active site 1124983017563 catalytic triad [active] 1124983017564 dimer interface [polypeptide binding]; other site 1124983017565 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1124983017566 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1124983017567 FAD binding pocket [chemical binding]; other site 1124983017568 FAD binding motif [chemical binding]; other site 1124983017569 phosphate binding motif [ion binding]; other site 1124983017570 beta-alpha-beta structure motif; other site 1124983017571 NAD binding pocket [chemical binding]; other site 1124983017572 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983017573 catalytic loop [active] 1124983017574 iron binding site [ion binding]; other site 1124983017575 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1124983017576 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1124983017577 [2Fe-2S] cluster binding site [ion binding]; other site 1124983017578 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1124983017579 putative alpha subunit interface [polypeptide binding]; other site 1124983017580 putative active site [active] 1124983017581 putative substrate binding site [chemical binding]; other site 1124983017582 Fe binding site [ion binding]; other site 1124983017583 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1124983017584 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1124983017585 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1124983017586 Ligand binding site [chemical binding]; other site 1124983017587 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1124983017588 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1124983017589 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1124983017590 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1124983017591 Cysteine-rich domain; Region: CCG; pfam02754 1124983017592 Cysteine-rich domain; Region: CCG; pfam02754 1124983017593 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1124983017594 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1124983017595 putative active site [active] 1124983017596 putative FMN binding site [chemical binding]; other site 1124983017597 putative substrate binding site [chemical binding]; other site 1124983017598 putative catalytic residue [active] 1124983017599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983017600 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1124983017601 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1124983017602 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1124983017603 active site 1124983017604 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1124983017605 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1124983017606 active site 1124983017607 homotetramer interface [polypeptide binding]; other site 1124983017608 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1124983017609 nucleoside/Zn binding site; other site 1124983017610 dimer interface [polypeptide binding]; other site 1124983017611 catalytic motif [active] 1124983017612 xanthine permease; Region: pbuX; TIGR03173 1124983017613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983017614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983017615 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1124983017616 dimerization interface [polypeptide binding]; other site 1124983017617 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1124983017618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983017619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1124983017620 non-specific DNA binding site [nucleotide binding]; other site 1124983017621 salt bridge; other site 1124983017622 sequence-specific DNA binding site [nucleotide binding]; other site 1124983017623 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 1124983017624 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1124983017625 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1124983017626 conserved cys residue [active] 1124983017627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983017628 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1124983017629 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1124983017630 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1124983017631 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1124983017632 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1124983017633 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1124983017634 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1124983017635 active site 1124983017636 Protein of unknown function (DUF971); Region: DUF971; cl01414 1124983017637 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 1124983017638 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1124983017639 substrate binding pocket [chemical binding]; other site 1124983017640 active site 1124983017641 iron coordination sites [ion binding]; other site 1124983017642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983017643 Coenzyme A binding pocket [chemical binding]; other site 1124983017644 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1124983017645 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1124983017646 conserved cys residue [active] 1124983017647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983017648 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1124983017649 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1124983017650 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1124983017651 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1124983017652 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1124983017653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983017654 dimer interface [polypeptide binding]; other site 1124983017655 conserved gate region; other site 1124983017656 putative PBP binding loops; other site 1124983017657 ABC-ATPase subunit interface; other site 1124983017658 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1124983017659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983017660 Walker A/P-loop; other site 1124983017661 ATP binding site [chemical binding]; other site 1124983017662 Q-loop/lid; other site 1124983017663 ABC transporter signature motif; other site 1124983017664 Walker B; other site 1124983017665 D-loop; other site 1124983017666 H-loop/switch region; other site 1124983017667 BCCT family transporter; Region: BCCT; cl00569 1124983017668 transcriptional regulator BetI; Validated; Region: PRK00767 1124983017669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983017670 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1124983017671 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1124983017672 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1124983017673 tetrameric interface [polypeptide binding]; other site 1124983017674 NAD binding site [chemical binding]; other site 1124983017675 catalytic residues [active] 1124983017676 choline dehydrogenase; Validated; Region: PRK02106 1124983017677 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1124983017678 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1124983017679 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1124983017680 putative transporter; Provisional; Region: PRK10504 1124983017681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983017682 putative substrate translocation pore; other site 1124983017683 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1124983017684 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124983017685 ATP binding site [chemical binding]; other site 1124983017686 Mg++ binding site [ion binding]; other site 1124983017687 motif III; other site 1124983017688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983017689 nucleotide binding region [chemical binding]; other site 1124983017690 ATP-binding site [chemical binding]; other site 1124983017691 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1124983017692 putative RNA binding site [nucleotide binding]; other site 1124983017693 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1124983017694 HI0933-like protein; Region: HI0933_like; pfam03486 1124983017695 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1124983017696 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1124983017697 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1124983017698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983017699 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983017700 substrate binding pocket [chemical binding]; other site 1124983017701 membrane-bound complex binding site; other site 1124983017702 hinge residues; other site 1124983017703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983017704 Coenzyme A binding pocket [chemical binding]; other site 1124983017705 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904 1124983017706 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1124983017707 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983017708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983017709 active site 1124983017710 phosphorylation site [posttranslational modification] 1124983017711 intermolecular recognition site; other site 1124983017712 dimerization interface [polypeptide binding]; other site 1124983017713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983017714 PAS domain; Region: PAS_9; pfam13426 1124983017715 putative active site [active] 1124983017716 heme pocket [chemical binding]; other site 1124983017717 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983017718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983017719 metal binding site [ion binding]; metal-binding site 1124983017720 active site 1124983017721 I-site; other site 1124983017722 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983017723 Alginate lyase; Region: Alginate_lyase2; pfam08787 1124983017724 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1124983017725 intersubunit interface [polypeptide binding]; other site 1124983017726 active site 1124983017727 zinc binding site [ion binding]; other site 1124983017728 Na+ binding site [ion binding]; other site 1124983017729 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1124983017730 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1124983017731 Phosphoglycerate kinase; Region: PGK; pfam00162 1124983017732 substrate binding site [chemical binding]; other site 1124983017733 hinge regions; other site 1124983017734 ADP binding site [chemical binding]; other site 1124983017735 catalytic site [active] 1124983017736 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1124983017737 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1124983017738 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1124983017739 transketolase; Reviewed; Region: PRK12753 1124983017740 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1124983017741 TPP-binding site [chemical binding]; other site 1124983017742 dimer interface [polypeptide binding]; other site 1124983017743 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1124983017744 PYR/PP interface [polypeptide binding]; other site 1124983017745 dimer interface [polypeptide binding]; other site 1124983017746 TPP binding site [chemical binding]; other site 1124983017747 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1124983017748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983017749 putative DNA binding site [nucleotide binding]; other site 1124983017750 putative Zn2+ binding site [ion binding]; other site 1124983017751 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1124983017752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983017753 S-adenosylmethionine binding site [chemical binding]; other site 1124983017754 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1124983017755 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1124983017756 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1124983017757 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1124983017758 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1124983017759 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1124983017760 nucleotide binding pocket [chemical binding]; other site 1124983017761 K-X-D-G motif; other site 1124983017762 catalytic site [active] 1124983017763 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1124983017764 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1124983017765 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1124983017766 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1124983017767 MltA specific insert domain; Region: MltA; smart00925 1124983017768 3D domain; Region: 3D; pfam06725 1124983017769 Predicted membrane protein [Function unknown]; Region: COG3686 1124983017770 EamA-like transporter family; Region: EamA; cl17759 1124983017771 EamA-like transporter family; Region: EamA; pfam00892 1124983017772 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1124983017773 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1124983017774 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1124983017775 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1124983017776 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1124983017777 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1124983017778 homotetramer interface [polypeptide binding]; other site 1124983017779 ligand binding site [chemical binding]; other site 1124983017780 catalytic site [active] 1124983017781 NAD binding site [chemical binding]; other site 1124983017782 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1124983017783 FAD binding site [chemical binding]; other site 1124983017784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983017785 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983017786 substrate binding pocket [chemical binding]; other site 1124983017787 membrane-bound complex binding site; other site 1124983017788 hinge residues; other site 1124983017789 helicase 45; Provisional; Region: PTZ00424 1124983017790 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1124983017791 ATP binding site [chemical binding]; other site 1124983017792 Mg++ binding site [ion binding]; other site 1124983017793 motif III; other site 1124983017794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983017795 nucleotide binding region [chemical binding]; other site 1124983017796 ATP-binding site [chemical binding]; other site 1124983017797 hypothetical protein; Provisional; Region: PRK03757 1124983017798 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1124983017799 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1124983017800 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983017801 inhibitor-cofactor binding pocket; inhibition site 1124983017802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983017803 catalytic residue [active] 1124983017804 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1124983017805 RNA methyltransferase, RsmE family; Region: TIGR00046 1124983017806 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1124983017807 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983017808 substrate binding pocket [chemical binding]; other site 1124983017809 membrane-bound complex binding site; other site 1124983017810 hinge residues; other site 1124983017811 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1124983017812 homotrimer interaction site [polypeptide binding]; other site 1124983017813 putative active site [active] 1124983017814 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1124983017815 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1124983017816 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983017817 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1124983017818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983017819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983017820 dimerization interface [polypeptide binding]; other site 1124983017821 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1124983017822 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1124983017823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983017824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983017825 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1124983017826 putative dimerization interface [polypeptide binding]; other site 1124983017827 malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808 1124983017828 Malonate transporter MadL subunit; Region: MadL; cl04273 1124983017829 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1124983017830 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1124983017831 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1124983017832 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1124983017833 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1124983017834 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1124983017835 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 1124983017836 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1124983017837 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1124983017838 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1124983017839 CheW-like domain; Region: CheW; pfam01584 1124983017840 Hpt domain; Region: Hpt; pfam01627 1124983017841 putative binding surface; other site 1124983017842 active site 1124983017843 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983017844 putative binding surface; other site 1124983017845 active site 1124983017846 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1124983017847 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983017848 putative binding surface; other site 1124983017849 active site 1124983017850 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1124983017851 putative binding surface; other site 1124983017852 active site 1124983017853 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1124983017854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983017855 ATP binding site [chemical binding]; other site 1124983017856 Mg2+ binding site [ion binding]; other site 1124983017857 G-X-G motif; other site 1124983017858 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1124983017859 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983017860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983017861 active site 1124983017862 phosphorylation site [posttranslational modification] 1124983017863 intermolecular recognition site; other site 1124983017864 dimerization interface [polypeptide binding]; other site 1124983017865 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1124983017866 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983017867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983017868 dimer interface [polypeptide binding]; other site 1124983017869 putative CheW interface [polypeptide binding]; other site 1124983017870 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1124983017871 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983017872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983017873 active site 1124983017874 phosphorylation site [posttranslational modification] 1124983017875 intermolecular recognition site; other site 1124983017876 dimerization interface [polypeptide binding]; other site 1124983017877 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983017878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983017879 active site 1124983017880 phosphorylation site [posttranslational modification] 1124983017881 intermolecular recognition site; other site 1124983017882 dimerization interface [polypeptide binding]; other site 1124983017883 glutathione synthetase; Provisional; Region: PRK05246 1124983017884 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1124983017885 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1124983017886 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1124983017887 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1124983017888 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1124983017889 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1124983017890 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983017891 active site 1124983017892 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1124983017893 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1124983017894 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1124983017895 dihydroorotase; Validated; Region: pyrC; PRK09357 1124983017896 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1124983017897 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1124983017898 active site 1124983017899 TM2 domain; Region: TM2; cl00984 1124983017900 TM2 domain; Region: TM2; pfam05154 1124983017901 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1124983017902 NlpC/P60 family; Region: NLPC_P60; pfam00877 1124983017903 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1124983017904 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124983017905 Walker A motif; other site 1124983017906 ATP binding site [chemical binding]; other site 1124983017907 Walker B motif; other site 1124983017908 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1124983017909 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983017910 catalytic residue [active] 1124983017911 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1124983017912 pyrroline-5-carboxylate reductase; Region: PLN02688 1124983017913 YGGT family; Region: YGGT; pfam02325 1124983017914 YGGT family; Region: YGGT; pfam02325 1124983017915 hypothetical protein; Validated; Region: PRK05090 1124983017916 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1124983017917 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1124983017918 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1124983017919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983017920 S-adenosylmethionine binding site [chemical binding]; other site 1124983017921 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1124983017922 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1124983017923 active site 1124983017924 dimerization interface [polypeptide binding]; other site 1124983017925 HemN family oxidoreductase; Provisional; Region: PRK05660 1124983017926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1124983017927 FeS/SAM binding site; other site 1124983017928 HemN C-terminal domain; Region: HemN_C; pfam06969 1124983017929 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 1124983017930 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1124983017931 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1124983017932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983017933 S-adenosylmethionine binding site [chemical binding]; other site 1124983017934 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1124983017935 ThiS interaction site; other site 1124983017936 putative active site [active] 1124983017937 tetramer interface [polypeptide binding]; other site 1124983017938 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1124983017939 thiS-thiF/thiG interaction site; other site 1124983017940 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1124983017941 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1124983017942 Transglycosylase; Region: Transgly; cl17702 1124983017943 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1124983017944 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1124983017945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1124983017946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1124983017947 DNA binding residues [nucleotide binding] 1124983017948 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1124983017949 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1124983017950 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1124983017951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983017952 Walker A/P-loop; other site 1124983017953 ATP binding site [chemical binding]; other site 1124983017954 Q-loop/lid; other site 1124983017955 ABC transporter signature motif; other site 1124983017956 Walker B; other site 1124983017957 D-loop; other site 1124983017958 H-loop/switch region; other site 1124983017959 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1124983017960 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1124983017961 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1124983017962 P loop; other site 1124983017963 GTP binding site [chemical binding]; other site 1124983017964 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1124983017965 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1124983017966 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1124983017967 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1124983017968 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1124983017969 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1124983017970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983017971 S-adenosylmethionine binding site [chemical binding]; other site 1124983017972 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1124983017973 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1124983017974 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1124983017975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983017976 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1124983017977 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1124983017978 active site residue [active] 1124983017979 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1124983017980 active site residue [active] 1124983017981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983017982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983017983 Bacterial transcriptional repressor; Region: TetR; pfam13972 1124983017984 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1124983017985 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1124983017986 NAD(P) binding site [chemical binding]; other site 1124983017987 catalytic residues [active] 1124983017988 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1124983017989 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1124983017990 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1124983017991 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1124983017992 active site 1124983017993 (T/H)XGH motif; other site 1124983017994 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1124983017995 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1124983017996 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1124983017997 DNA binding site [nucleotide binding] 1124983017998 catalytic residue [active] 1124983017999 H2TH interface [polypeptide binding]; other site 1124983018000 putative catalytic residues [active] 1124983018001 turnover-facilitating residue; other site 1124983018002 intercalation triad [nucleotide binding]; other site 1124983018003 8OG recognition residue [nucleotide binding]; other site 1124983018004 putative reading head residues; other site 1124983018005 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1124983018006 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1124983018007 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1124983018008 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1124983018009 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1124983018010 putative RNA binding site [nucleotide binding]; other site 1124983018011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983018012 S-adenosylmethionine binding site [chemical binding]; other site 1124983018013 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1124983018014 putative FMN binding site [chemical binding]; other site 1124983018015 NADPH bind site [chemical binding]; other site 1124983018016 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1124983018017 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1124983018018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983018019 putative substrate translocation pore; other site 1124983018020 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1124983018021 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1124983018022 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 1124983018023 active site 1124983018024 oxyanion hole [active] 1124983018025 catalytic triad [active] 1124983018026 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 1124983018027 active site 1124983018028 catalytic triad [active] 1124983018029 oxyanion hole [active] 1124983018030 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1124983018031 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1124983018032 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1124983018033 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1124983018034 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1124983018035 folate binding site [chemical binding]; other site 1124983018036 NADP+ binding site [chemical binding]; other site 1124983018037 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1124983018038 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1124983018039 G1 box; other site 1124983018040 GTP/Mg2+ binding site [chemical binding]; other site 1124983018041 G2 box; other site 1124983018042 Switch I region; other site 1124983018043 G3 box; other site 1124983018044 Switch II region; other site 1124983018045 G4 box; other site 1124983018046 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1124983018047 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983018048 Zn2+ binding site [ion binding]; other site 1124983018049 Mg2+ binding site [ion binding]; other site 1124983018050 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1124983018051 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983018052 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1124983018053 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 1124983018054 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1124983018055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018056 dimer interface [polypeptide binding]; other site 1124983018057 conserved gate region; other site 1124983018058 putative PBP binding loops; other site 1124983018059 ABC-ATPase subunit interface; other site 1124983018060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018061 dimer interface [polypeptide binding]; other site 1124983018062 conserved gate region; other site 1124983018063 putative PBP binding loops; other site 1124983018064 ABC-ATPase subunit interface; other site 1124983018065 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1124983018066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983018067 Walker A/P-loop; other site 1124983018068 ATP binding site [chemical binding]; other site 1124983018069 Q-loop/lid; other site 1124983018070 ABC transporter signature motif; other site 1124983018071 Walker B; other site 1124983018072 D-loop; other site 1124983018073 H-loop/switch region; other site 1124983018074 TOBE domain; Region: TOBE_2; pfam08402 1124983018075 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1124983018076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983018077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983018078 dimerization interface [polypeptide binding]; other site 1124983018079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1124983018080 Heavy-metal-associated domain; Region: HMA; pfam00403 1124983018081 metal-binding site [ion binding] 1124983018082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124983018083 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1124983018084 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1124983018085 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1124983018086 DNA binding residues [nucleotide binding] 1124983018087 dimer interface [polypeptide binding]; other site 1124983018088 putative metal binding site [ion binding]; other site 1124983018089 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1124983018090 active site 1124983018091 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124983018092 thymidylate synthase; Provisional; Region: thyA; PRK13821 1124983018093 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1124983018094 dimerization interface [polypeptide binding]; other site 1124983018095 active site 1124983018096 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1124983018097 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1124983018098 NRDE protein; Region: NRDE; cl01315 1124983018099 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1124983018100 GAF domain; Region: GAF; pfam01590 1124983018101 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1124983018102 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1124983018103 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1124983018104 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1124983018105 putative active site [active] 1124983018106 Ap4A binding site [chemical binding]; other site 1124983018107 nudix motif; other site 1124983018108 putative metal binding site [ion binding]; other site 1124983018109 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1124983018110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983018111 motif II; other site 1124983018112 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1124983018113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983018114 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1124983018115 NAD(P) binding site [chemical binding]; other site 1124983018116 active site 1124983018117 DoxX-like family; Region: DoxX_3; pfam13781 1124983018118 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1124983018119 threonine dehydratase; Reviewed; Region: PRK09224 1124983018120 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1124983018121 tetramer interface [polypeptide binding]; other site 1124983018122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983018123 catalytic residue [active] 1124983018124 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1124983018125 putative Ile/Val binding site [chemical binding]; other site 1124983018126 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1124983018127 putative Ile/Val binding site [chemical binding]; other site 1124983018128 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1124983018129 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1124983018130 active site 1124983018131 dimer interface [polypeptide binding]; other site 1124983018132 SdiA-regulated; Region: SdiA-regulated; pfam06977 1124983018133 SdiA-regulated; Region: SdiA-regulated; cd09971 1124983018134 putative active site [active] 1124983018135 SdiA-regulated; Region: SdiA-regulated; pfam06977 1124983018136 SdiA-regulated; Region: SdiA-regulated; cd09971 1124983018137 putative active site [active] 1124983018138 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1124983018139 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1124983018140 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1124983018141 FAD binding domain; Region: FAD_binding_4; pfam01565 1124983018142 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1124983018143 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1124983018144 ligand binding site [chemical binding]; other site 1124983018145 NAD binding site [chemical binding]; other site 1124983018146 tetramer interface [polypeptide binding]; other site 1124983018147 catalytic site [active] 1124983018148 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1124983018149 L-serine binding site [chemical binding]; other site 1124983018150 ACT domain interface; other site 1124983018151 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1124983018152 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983018153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983018154 substrate binding pocket [chemical binding]; other site 1124983018155 membrane-bound complex binding site; other site 1124983018156 hinge residues; other site 1124983018157 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1124983018158 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1124983018159 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1124983018160 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1124983018161 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983018162 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1124983018163 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1124983018164 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1124983018165 active site 1124983018166 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1124983018167 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1124983018168 conserved cys residue [active] 1124983018169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983018170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1124983018171 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1124983018172 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124983018173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018174 dimer interface [polypeptide binding]; other site 1124983018175 conserved gate region; other site 1124983018176 putative PBP binding loops; other site 1124983018177 ABC-ATPase subunit interface; other site 1124983018178 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1124983018179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018180 dimer interface [polypeptide binding]; other site 1124983018181 conserved gate region; other site 1124983018182 putative PBP binding loops; other site 1124983018183 ABC-ATPase subunit interface; other site 1124983018184 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1124983018185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983018186 Walker A/P-loop; other site 1124983018187 ATP binding site [chemical binding]; other site 1124983018188 Q-loop/lid; other site 1124983018189 ABC transporter signature motif; other site 1124983018190 Walker B; other site 1124983018191 D-loop; other site 1124983018192 H-loop/switch region; other site 1124983018193 TOBE domain; Region: TOBE_2; pfam08402 1124983018194 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983018195 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983018196 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983018197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983018198 putative aminotransferase; Validated; Region: PRK07480 1124983018199 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1124983018200 inhibitor-cofactor binding pocket; inhibition site 1124983018201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983018202 catalytic residue [active] 1124983018203 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1124983018204 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124983018205 Peptidase C26; Region: Peptidase_C26; pfam07722 1124983018206 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1124983018207 catalytic triad [active] 1124983018208 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1124983018209 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1124983018210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983018211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983018212 pantothenate kinase; Provisional; Region: PRK05439 1124983018213 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1124983018214 CoA-binding site [chemical binding]; other site 1124983018215 Mg2+-binding site [ion binding]; other site 1124983018216 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1124983018217 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1124983018218 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1124983018219 Walker A/P-loop; other site 1124983018220 ATP binding site [chemical binding]; other site 1124983018221 Q-loop/lid; other site 1124983018222 ABC transporter signature motif; other site 1124983018223 Walker B; other site 1124983018224 D-loop; other site 1124983018225 H-loop/switch region; other site 1124983018226 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1124983018227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018228 dimer interface [polypeptide binding]; other site 1124983018229 conserved gate region; other site 1124983018230 putative PBP binding loops; other site 1124983018231 ABC-ATPase subunit interface; other site 1124983018232 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1124983018233 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1124983018234 active site 1124983018235 dimer interface [polypeptide binding]; other site 1124983018236 non-prolyl cis peptide bond; other site 1124983018237 insertion regions; other site 1124983018238 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1124983018239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983018240 substrate binding pocket [chemical binding]; other site 1124983018241 membrane-bound complex binding site; other site 1124983018242 hinge residues; other site 1124983018243 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1124983018244 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1124983018245 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1124983018246 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1124983018247 dimer interface [polypeptide binding]; other site 1124983018248 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1124983018249 catalytic triad [active] 1124983018250 outer membrane porin, OprD family; Region: OprD; pfam03573 1124983018251 N-acetylglutamate synthase; Validated; Region: PRK05279 1124983018252 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1124983018253 putative feedback inhibition sensing region; other site 1124983018254 putative nucleotide binding site [chemical binding]; other site 1124983018255 putative substrate binding site [chemical binding]; other site 1124983018256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983018257 Coenzyme A binding pocket [chemical binding]; other site 1124983018258 acetylornithine deacetylase; Provisional; Region: PRK05111 1124983018259 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1124983018260 metal binding site [ion binding]; metal-binding site 1124983018261 putative dimer interface [polypeptide binding]; other site 1124983018262 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1124983018263 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1124983018264 putative active site [active] 1124983018265 putative metal binding residues [ion binding]; other site 1124983018266 signature motif; other site 1124983018267 putative triphosphate binding site [ion binding]; other site 1124983018268 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983018269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983018270 putative DNA binding site [nucleotide binding]; other site 1124983018271 putative Zn2+ binding site [ion binding]; other site 1124983018272 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983018273 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1124983018274 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1124983018275 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1124983018276 Walker A motif; other site 1124983018277 ATP binding site [chemical binding]; other site 1124983018278 Walker B motif; other site 1124983018279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983018280 dimerization interface [polypeptide binding]; other site 1124983018281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983018282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983018283 dimer interface [polypeptide binding]; other site 1124983018284 putative CheW interface [polypeptide binding]; other site 1124983018285 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1124983018286 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1124983018287 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1124983018288 conserverd hypothetical protein; Region: TIGR02448 1124983018289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983018290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983018291 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1124983018292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983018293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983018294 hypothetical protein; Provisional; Region: PRK04262 1124983018295 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1124983018296 dimer interface [polypeptide binding]; other site 1124983018297 active site 1124983018298 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1124983018299 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1124983018300 active site 1124983018301 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1124983018302 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1124983018303 DUF35 OB-fold domain; Region: DUF35; pfam01796 1124983018304 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1124983018305 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1124983018306 malonyl-CoA binding site [chemical binding]; other site 1124983018307 dimer interface [polypeptide binding]; other site 1124983018308 active site 1124983018309 product binding site; other site 1124983018310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983018311 putative substrate translocation pore; other site 1124983018312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983018313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1124983018314 glycine dehydrogenase; Provisional; Region: PRK12566 1124983018315 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1124983018316 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1124983018317 catalytic residue [active] 1124983018318 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1124983018319 tetramer interface [polypeptide binding]; other site 1124983018320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983018321 catalytic residue [active] 1124983018322 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1124983018323 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1124983018324 inhibitor-cofactor binding pocket; inhibition site 1124983018325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983018326 catalytic residue [active] 1124983018327 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1124983018328 lipoyl attachment site [posttranslational modification]; other site 1124983018329 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1124983018330 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1124983018331 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1124983018332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018333 dimer interface [polypeptide binding]; other site 1124983018334 conserved gate region; other site 1124983018335 putative PBP binding loops; other site 1124983018336 ABC-ATPase subunit interface; other site 1124983018337 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1124983018338 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1124983018339 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1124983018340 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1124983018341 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1124983018342 active site 2 [active] 1124983018343 active site 1 [active] 1124983018344 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1124983018345 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1124983018346 proline aminopeptidase P II; Provisional; Region: PRK10879 1124983018347 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1124983018348 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1124983018349 active site 1124983018350 hypothetical protein; Reviewed; Region: PRK02166 1124983018351 TIGR02449 family protein; Region: TIGR02449 1124983018352 Cell division protein ZapA; Region: ZapA; pfam05164 1124983018353 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1124983018354 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1124983018355 EVE domain; Region: EVE; cl00728 1124983018356 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1124983018357 HlyD family secretion protein; Region: HlyD_3; pfam13437 1124983018358 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1124983018359 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1124983018360 Walker A/P-loop; other site 1124983018361 ATP binding site [chemical binding]; other site 1124983018362 Q-loop/lid; other site 1124983018363 ABC transporter signature motif; other site 1124983018364 Walker B; other site 1124983018365 D-loop; other site 1124983018366 H-loop/switch region; other site 1124983018367 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1124983018368 Walker A/P-loop; other site 1124983018369 ATP binding site [chemical binding]; other site 1124983018370 Q-loop/lid; other site 1124983018371 ABC transporter signature motif; other site 1124983018372 Walker B; other site 1124983018373 D-loop; other site 1124983018374 H-loop/switch region; other site 1124983018375 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1124983018376 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124983018377 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1124983018378 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1124983018379 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1124983018380 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 1124983018381 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1124983018382 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1124983018383 NAD(P) binding site [chemical binding]; other site 1124983018384 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1124983018385 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1124983018386 putative active site pocket [active] 1124983018387 dimerization interface [polypeptide binding]; other site 1124983018388 putative catalytic residue [active] 1124983018389 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1124983018390 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1124983018391 catalytic loop [active] 1124983018392 iron binding site [ion binding]; other site 1124983018393 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1124983018394 FAD binding pocket [chemical binding]; other site 1124983018395 FAD binding motif [chemical binding]; other site 1124983018396 phosphate binding motif [ion binding]; other site 1124983018397 beta-alpha-beta structure motif; other site 1124983018398 NAD binding pocket [chemical binding]; other site 1124983018399 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1124983018400 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1124983018401 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1124983018402 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1124983018403 RNA binding site [nucleotide binding]; other site 1124983018404 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1124983018405 multimer interface [polypeptide binding]; other site 1124983018406 Walker A motif; other site 1124983018407 ATP binding site [chemical binding]; other site 1124983018408 Walker B motif; other site 1124983018409 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1124983018410 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1124983018411 catalytic residues [active] 1124983018412 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1124983018413 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1124983018414 polyphosphate kinase; Provisional; Region: PRK05443 1124983018415 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1124983018416 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1124983018417 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1124983018418 putative active site [active] 1124983018419 catalytic site [active] 1124983018420 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1124983018421 putative domain interface [polypeptide binding]; other site 1124983018422 putative active site [active] 1124983018423 catalytic site [active] 1124983018424 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1124983018425 dimer interface [polypeptide binding]; other site 1124983018426 active site 1124983018427 aspartate-rich active site metal binding site; other site 1124983018428 allosteric magnesium binding site [ion binding]; other site 1124983018429 Schiff base residues; other site 1124983018430 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1124983018431 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1124983018432 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1124983018433 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1124983018434 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1124983018435 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1124983018436 conserved cys residue [active] 1124983018437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1124983018438 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1124983018439 Cytochrome c; Region: Cytochrom_C; pfam00034 1124983018440 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1124983018441 LysE type translocator; Region: LysE; cl00565 1124983018442 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1124983018443 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1124983018444 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1124983018445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983018446 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983018447 ABC transporter; Region: ABC_tran_2; pfam12848 1124983018448 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1124983018449 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1124983018450 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1124983018451 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1124983018452 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1124983018453 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1124983018454 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1124983018455 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1124983018456 HemY protein N-terminus; Region: HemY_N; pfam07219 1124983018457 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1124983018458 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1124983018459 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1124983018460 active site 1124983018461 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1124983018462 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1124983018463 domain interfaces; other site 1124983018464 active site 1124983018465 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1124983018466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983018467 active site 1124983018468 phosphorylation site [posttranslational modification] 1124983018469 intermolecular recognition site; other site 1124983018470 dimerization interface [polypeptide binding]; other site 1124983018471 LytTr DNA-binding domain; Region: LytTR; pfam04397 1124983018472 argininosuccinate lyase; Provisional; Region: PRK00855 1124983018473 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1124983018474 active sites [active] 1124983018475 tetramer interface [polypeptide binding]; other site 1124983018476 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983018477 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1124983018478 C-terminal domain interface [polypeptide binding]; other site 1124983018479 GSH binding site (G-site) [chemical binding]; other site 1124983018480 dimer interface [polypeptide binding]; other site 1124983018481 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 1124983018482 putative N-terminal domain interface [polypeptide binding]; other site 1124983018483 putative dimer interface [polypeptide binding]; other site 1124983018484 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983018485 TIGR02647 family protein; Region: DNA 1124983018486 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1124983018487 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1124983018488 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1124983018489 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1124983018490 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1124983018491 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1124983018492 frataxin-like protein; Provisional; Region: cyaY; PRK00446 1124983018493 putative iron binding site [ion binding]; other site 1124983018494 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1124983018495 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1124983018496 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1124983018497 active site 1124983018498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983018499 substrate binding site [chemical binding]; other site 1124983018500 catalytic residues [active] 1124983018501 dimer interface [polypeptide binding]; other site 1124983018502 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1124983018503 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1124983018504 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1124983018505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3159 1124983018506 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1124983018507 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1124983018508 active site 1124983018509 DNA binding site [nucleotide binding] 1124983018510 Int/Topo IB signature motif; other site 1124983018511 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1124983018512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1124983018513 motif II; other site 1124983018514 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1124983018515 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1124983018516 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1124983018517 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1124983018518 Membrane fusogenic activity; Region: BMFP; pfam04380 1124983018519 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1124983018520 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1124983018521 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1124983018522 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1124983018523 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1124983018524 active site 1124983018525 catalytic residues [active] 1124983018526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1124983018527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1124983018528 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1124983018529 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 1124983018530 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1124983018531 active site 1124983018532 catalytic site [active] 1124983018533 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1124983018534 dimerization interface [polypeptide binding]; other site 1124983018535 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1124983018536 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1124983018537 dimer interface [polypeptide binding]; other site 1124983018538 putative CheW interface [polypeptide binding]; other site 1124983018539 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1124983018540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983018541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1124983018542 dimerization interface [polypeptide binding]; other site 1124983018543 multidrug efflux protein NorA; Provisional; Region: PRK00187 1124983018544 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1124983018545 cation binding site [ion binding]; other site 1124983018546 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983018547 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983018548 metal binding site [ion binding]; metal-binding site 1124983018549 active site 1124983018550 I-site; other site 1124983018551 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983018552 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1124983018553 Part of AAA domain; Region: AAA_19; pfam13245 1124983018554 Family description; Region: UvrD_C_2; pfam13538 1124983018555 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983018556 active site 1124983018557 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1124983018558 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1124983018559 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1124983018560 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1124983018561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983018562 non-specific DNA binding site [nucleotide binding]; other site 1124983018563 salt bridge; other site 1124983018564 sequence-specific DNA binding site [nucleotide binding]; other site 1124983018565 Cupin domain; Region: Cupin_2; pfam07883 1124983018566 alanine racemase; Reviewed; Region: dadX; PRK03646 1124983018567 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1124983018568 active site 1124983018569 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1124983018570 substrate binding site [chemical binding]; other site 1124983018571 catalytic residues [active] 1124983018572 dimer interface [polypeptide binding]; other site 1124983018573 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1124983018574 homotrimer interaction site [polypeptide binding]; other site 1124983018575 putative active site [active] 1124983018576 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1124983018577 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1124983018578 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1124983018579 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1124983018580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983018581 putative DNA binding site [nucleotide binding]; other site 1124983018582 putative Zn2+ binding site [ion binding]; other site 1124983018583 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983018584 Flagellin N-methylase; Region: FliB; pfam03692 1124983018585 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1124983018586 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1124983018587 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983018588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983018589 DNA-binding site [nucleotide binding]; DNA binding site 1124983018590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983018591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983018592 homodimer interface [polypeptide binding]; other site 1124983018593 catalytic residue [active] 1124983018594 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1124983018595 PLD-like domain; Region: PLDc_2; pfam13091 1124983018596 putative active site [active] 1124983018597 catalytic site [active] 1124983018598 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1124983018599 PLD-like domain; Region: PLDc_2; pfam13091 1124983018600 putative active site [active] 1124983018601 catalytic site [active] 1124983018602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983018603 putative substrate translocation pore; other site 1124983018604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1124983018605 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1124983018606 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1124983018607 NAD(P) binding site [chemical binding]; other site 1124983018608 catalytic residues [active] 1124983018609 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1124983018610 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1124983018611 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1124983018612 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1124983018613 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1124983018614 peptide binding site [polypeptide binding]; other site 1124983018615 hypothetical protein; Reviewed; Region: PRK00024 1124983018616 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1124983018617 MPN+ (JAMM) motif; other site 1124983018618 Zinc-binding site [ion binding]; other site 1124983018619 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1124983018620 Flavoprotein; Region: Flavoprotein; pfam02441 1124983018621 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1124983018622 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1124983018623 trimer interface [polypeptide binding]; other site 1124983018624 active site 1124983018625 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1124983018626 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1124983018627 active site 1124983018628 substrate binding site [chemical binding]; other site 1124983018629 metal binding site [ion binding]; metal-binding site 1124983018630 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1124983018631 feedback inhibition sensing region; other site 1124983018632 homohexameric interface [polypeptide binding]; other site 1124983018633 nucleotide binding site [chemical binding]; other site 1124983018634 N-acetyl-L-glutamate binding site [chemical binding]; other site 1124983018635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1124983018636 active site 1124983018637 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1124983018638 putative active site [active] 1124983018639 putative catalytic site [active] 1124983018640 putative DNA binding site [nucleotide binding]; other site 1124983018641 putative phosphate binding site [ion binding]; other site 1124983018642 metal binding site A [ion binding]; metal-binding site 1124983018643 putative AP binding site [nucleotide binding]; other site 1124983018644 putative metal binding site B [ion binding]; other site 1124983018645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1124983018646 ribonuclease PH; Reviewed; Region: rph; PRK00173 1124983018647 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1124983018648 hexamer interface [polypeptide binding]; other site 1124983018649 active site 1124983018650 hypothetical protein; Provisional; Region: PRK11820 1124983018651 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1124983018652 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1124983018653 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1124983018654 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1124983018655 catalytic site [active] 1124983018656 G-X2-G-X-G-K; other site 1124983018657 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1124983018658 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1124983018659 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1124983018660 Zn2+ binding site [ion binding]; other site 1124983018661 Mg2+ binding site [ion binding]; other site 1124983018662 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1124983018663 synthetase active site [active] 1124983018664 NTP binding site [chemical binding]; other site 1124983018665 metal binding site [ion binding]; metal-binding site 1124983018666 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1124983018667 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1124983018668 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1124983018669 homotrimer interaction site [polypeptide binding]; other site 1124983018670 putative active site [active] 1124983018671 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983018672 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1124983018673 putative NAD(P) binding site [chemical binding]; other site 1124983018674 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1124983018675 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1124983018676 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1124983018677 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1124983018678 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1124983018679 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1124983018680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983018681 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1124983018682 dimerization interface [polypeptide binding]; other site 1124983018683 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1124983018684 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1124983018685 generic binding surface II; other site 1124983018686 ssDNA binding site; other site 1124983018687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1124983018688 ATP binding site [chemical binding]; other site 1124983018689 putative Mg++ binding site [ion binding]; other site 1124983018690 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1124983018691 nucleotide binding region [chemical binding]; other site 1124983018692 ATP-binding site [chemical binding]; other site 1124983018693 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1124983018694 putative deacylase active site [active] 1124983018695 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1124983018696 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1124983018697 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1124983018698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983018699 Walker A/P-loop; other site 1124983018700 ATP binding site [chemical binding]; other site 1124983018701 Q-loop/lid; other site 1124983018702 ABC transporter signature motif; other site 1124983018703 Walker B; other site 1124983018704 D-loop; other site 1124983018705 H-loop/switch region; other site 1124983018706 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1124983018707 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1124983018708 active site 1124983018709 ATP binding site [chemical binding]; other site 1124983018710 substrate binding site [chemical binding]; other site 1124983018711 activation loop (A-loop); other site 1124983018712 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1124983018713 metal ion-dependent adhesion site (MIDAS); other site 1124983018714 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1124983018715 active site 1124983018716 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1124983018717 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1124983018718 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1124983018719 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1124983018720 hypothetical protein; Provisional; Region: PRK07033 1124983018721 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1124983018722 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1124983018723 ligand binding site [chemical binding]; other site 1124983018724 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1124983018725 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1124983018726 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 1124983018727 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1124983018728 phosphopeptide binding site; other site 1124983018729 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1124983018730 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1124983018731 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1124983018732 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1124983018733 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1124983018734 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1124983018735 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1124983018736 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1124983018737 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1124983018738 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1124983018739 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1124983018740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983018741 Walker A motif; other site 1124983018742 ATP binding site [chemical binding]; other site 1124983018743 Walker B motif; other site 1124983018744 arginine finger; other site 1124983018745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1124983018746 Walker A motif; other site 1124983018747 ATP binding site [chemical binding]; other site 1124983018748 Walker B motif; other site 1124983018749 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1124983018750 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1124983018751 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1124983018752 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1124983018753 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1124983018754 PAAR motif; Region: PAAR_motif; pfam05488 1124983018755 RHS Repeat; Region: RHS_repeat; cl11982 1124983018756 RHS Repeat; Region: RHS_repeat; pfam05593 1124983018757 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1124983018758 RHS Repeat; Region: RHS_repeat; pfam05593 1124983018759 RHS Repeat; Region: RHS_repeat; pfam05593 1124983018760 RHS Repeat; Region: RHS_repeat; pfam05593 1124983018761 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1124983018762 RHS protein; Region: RHS; pfam03527 1124983018763 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1124983018764 Uncharacterized conserved protein [Function unknown]; Region: COG5435 1124983018765 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1124983018766 IHF dimer interface [polypeptide binding]; other site 1124983018767 IHF - DNA interface [nucleotide binding]; other site 1124983018768 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1124983018769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1124983018770 hypothetical protein; Provisional; Region: PRK07236 1124983018771 Rubredoxin [Energy production and conversion]; Region: COG1773 1124983018772 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1124983018773 iron binding site [ion binding]; other site 1124983018774 Chorismate lyase; Region: Chor_lyase; cl01230 1124983018775 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1124983018776 UbiA prenyltransferase family; Region: UbiA; pfam01040 1124983018777 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1124983018778 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1124983018779 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1124983018780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983018781 active site 1124983018782 phosphorylation site [posttranslational modification] 1124983018783 intermolecular recognition site; other site 1124983018784 dimerization interface [polypeptide binding]; other site 1124983018785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1124983018786 DNA binding site [nucleotide binding] 1124983018787 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1124983018788 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1124983018789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983018790 putative active site [active] 1124983018791 heme pocket [chemical binding]; other site 1124983018792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1124983018793 dimer interface [polypeptide binding]; other site 1124983018794 phosphorylation site [posttranslational modification] 1124983018795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1124983018796 ATP binding site [chemical binding]; other site 1124983018797 Mg2+ binding site [ion binding]; other site 1124983018798 G-X-G motif; other site 1124983018799 Domain of unknown function DUF21; Region: DUF21; pfam01595 1124983018800 gliding motility-associated protein GldE; Region: GldE; TIGR03520 1124983018801 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1124983018802 Transporter associated domain; Region: CorC_HlyC; pfam03471 1124983018803 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1124983018804 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1124983018805 Peptidase family M23; Region: Peptidase_M23; pfam01551 1124983018806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983018807 sequence-specific DNA binding site [nucleotide binding]; other site 1124983018808 salt bridge; other site 1124983018809 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1124983018810 Response regulator receiver domain; Region: Response_reg; pfam00072 1124983018811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1124983018812 active site 1124983018813 phosphorylation site [posttranslational modification] 1124983018814 intermolecular recognition site; other site 1124983018815 dimerization interface [polypeptide binding]; other site 1124983018816 transcriptional regulator PhoU; Provisional; Region: PRK11115 1124983018817 PhoU domain; Region: PhoU; pfam01895 1124983018818 PhoU domain; Region: PhoU; pfam01895 1124983018819 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1124983018820 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1124983018821 Walker A/P-loop; other site 1124983018822 ATP binding site [chemical binding]; other site 1124983018823 Q-loop/lid; other site 1124983018824 ABC transporter signature motif; other site 1124983018825 Walker B; other site 1124983018826 D-loop; other site 1124983018827 H-loop/switch region; other site 1124983018828 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1124983018829 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1124983018830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018831 dimer interface [polypeptide binding]; other site 1124983018832 conserved gate region; other site 1124983018833 putative PBP binding loops; other site 1124983018834 ABC-ATPase subunit interface; other site 1124983018835 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1124983018836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018837 ABC-ATPase subunit interface; other site 1124983018838 phosphate binding protein; Region: ptsS_2; TIGR02136 1124983018839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1124983018840 metabolite-proton symporter; Region: 2A0106; TIGR00883 1124983018841 putative substrate translocation pore; other site 1124983018842 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1124983018843 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1124983018844 active site 1124983018845 phosphate binding residues; other site 1124983018846 catalytic residues [active] 1124983018847 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1124983018848 Predicted membrane protein [Function unknown]; Region: COG2261 1124983018849 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1124983018850 ATP-grasp domain; Region: ATP-grasp; pfam02222 1124983018851 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1124983018852 cell density-dependent motility repressor; Provisional; Region: PRK10082 1124983018853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983018854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1124983018855 dimerization interface [polypeptide binding]; other site 1124983018856 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1124983018857 Aspartase; Region: Aspartase; cd01357 1124983018858 active sites [active] 1124983018859 tetramer interface [polypeptide binding]; other site 1124983018860 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1124983018861 YcxB-like protein; Region: YcxB; pfam14317 1124983018862 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1124983018863 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1124983018864 dimer interface [polypeptide binding]; other site 1124983018865 active site 1124983018866 CoA binding pocket [chemical binding]; other site 1124983018867 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1124983018868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1124983018869 NAD(P) binding site [chemical binding]; other site 1124983018870 active site 1124983018871 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1124983018872 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1124983018873 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1124983018874 hypothetical protein; Provisional; Region: PRK06849 1124983018875 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1124983018876 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1124983018877 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1124983018878 iron-sulfur cluster [ion binding]; other site 1124983018879 [2Fe-2S] cluster binding site [ion binding]; other site 1124983018880 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1124983018881 amino acid carrier protein; Region: agcS; TIGR00835 1124983018882 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1124983018883 active site 1124983018884 homodimer interface [polypeptide binding]; other site 1124983018885 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1124983018886 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1124983018887 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1124983018888 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983018889 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1124983018890 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983018891 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1124983018892 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983018893 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1124983018894 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1124983018895 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1124983018896 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1124983018897 active site 1124983018898 Zn binding site [ion binding]; other site 1124983018899 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1124983018900 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1124983018901 Sulphur transport; Region: Sulf_transp; pfam04143 1124983018902 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1124983018903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1124983018904 DNA-binding site [nucleotide binding]; DNA binding site 1124983018905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1124983018906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1124983018907 homodimer interface [polypeptide binding]; other site 1124983018908 catalytic residue [active] 1124983018909 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1124983018910 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1124983018911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1124983018912 Coenzyme A binding pocket [chemical binding]; other site 1124983018913 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1124983018914 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1124983018915 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 1124983018916 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1124983018917 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1124983018918 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1124983018919 substrate binding pocket [chemical binding]; other site 1124983018920 membrane-bound complex binding site; other site 1124983018921 hinge residues; other site 1124983018922 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1124983018923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1124983018924 dimer interface [polypeptide binding]; other site 1124983018925 conserved gate region; other site 1124983018926 putative PBP binding loops; other site 1124983018927 ABC-ATPase subunit interface; other site 1124983018928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1124983018929 non-specific DNA binding site [nucleotide binding]; other site 1124983018930 salt bridge; other site 1124983018931 sequence-specific DNA binding site [nucleotide binding]; other site 1124983018932 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1124983018933 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1124983018934 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1124983018935 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1124983018936 active site 1124983018937 catalytic residues [active] 1124983018938 metal binding site [ion binding]; metal-binding site 1124983018939 homodimer binding site [polypeptide binding]; other site 1124983018940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1124983018941 carboxyltransferase (CT) interaction site; other site 1124983018942 biotinylation site [posttranslational modification]; other site 1124983018943 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1124983018944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1124983018945 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1124983018946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1124983018947 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983018948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983018949 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1124983018950 putative dimerization interface [polypeptide binding]; other site 1124983018951 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1124983018952 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1124983018953 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1124983018954 putative active site [active] 1124983018955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983018956 PAS fold; Region: PAS_3; pfam08447 1124983018957 putative active site [active] 1124983018958 heme pocket [chemical binding]; other site 1124983018959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1124983018960 PAS domain; Region: PAS_9; pfam13426 1124983018961 putative active site [active] 1124983018962 heme pocket [chemical binding]; other site 1124983018963 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1124983018964 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1124983018965 metal binding site [ion binding]; metal-binding site 1124983018966 active site 1124983018967 I-site; other site 1124983018968 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1124983018969 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1124983018970 Part of AAA domain; Region: AAA_19; pfam13245 1124983018971 Family description; Region: UvrD_C_2; pfam13538 1124983018972 Predicted membrane protein [Function unknown]; Region: COG2510 1124983018973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1124983018974 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1124983018975 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1124983018976 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1124983018977 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1124983018978 amino acid transporter; Region: 2A0306; TIGR00909 1124983018979 pyridoxamine kinase; Validated; Region: PRK05756 1124983018980 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1124983018981 pyridoxal binding site [chemical binding]; other site 1124983018982 dimer interface [polypeptide binding]; other site 1124983018983 ATP binding site [chemical binding]; other site 1124983018984 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1124983018985 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1124983018986 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1124983018987 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1124983018988 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1124983018989 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1124983018990 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1124983018991 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1124983018992 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1124983018993 AMIN domain; Region: AMIN; pfam11741 1124983018994 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1124983018995 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1124983018996 active site 1124983018997 metal binding site [ion binding]; metal-binding site 1124983018998 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1124983018999 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 1124983019000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1124983019001 Walker A/P-loop; other site 1124983019002 ATP binding site [chemical binding]; other site 1124983019003 Q-loop/lid; other site 1124983019004 ABC transporter signature motif; other site 1124983019005 Walker B; other site 1124983019006 D-loop; other site 1124983019007 H-loop/switch region; other site 1124983019008 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1124983019009 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1124983019010 ABC-ATPase subunit interface; other site 1124983019011 dimer interface [polypeptide binding]; other site 1124983019012 putative PBP binding regions; other site 1124983019013 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1124983019014 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1124983019015 metal binding site [ion binding]; metal-binding site 1124983019016 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1124983019017 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1124983019018 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1124983019019 trimer interface [polypeptide binding]; other site 1124983019020 active site 1124983019021 dihydroorotase; Reviewed; Region: PRK09236 1124983019022 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1124983019023 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1124983019024 active site 1124983019025 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1124983019026 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1124983019027 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1124983019028 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1124983019029 active site 1124983019030 dimer interface [polypeptide binding]; other site 1124983019031 motif 1; other site 1124983019032 motif 2; other site 1124983019033 motif 3; other site 1124983019034 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1124983019035 anticodon binding site; other site 1124983019036 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1124983019037 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1124983019038 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1124983019039 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1124983019040 putative active site [active] 1124983019041 catalytic site [active] 1124983019042 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1124983019043 putative active site [active] 1124983019044 catalytic site [active] 1124983019045 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1124983019046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983019047 S-adenosylmethionine binding site [chemical binding]; other site 1124983019048 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1124983019049 hypothetical protein; Provisional; Region: PRK05409 1124983019050 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1124983019051 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1124983019052 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1124983019053 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1124983019054 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1124983019055 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1124983019056 HflC protein; Region: hflC; TIGR01932 1124983019057 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1124983019058 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1124983019059 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1124983019060 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1124983019061 Putative methyltransferase; Region: Methyltransf_20; pfam12147 1124983019062 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1124983019063 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1124983019064 active site 1124983019065 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1124983019066 active site 1124983019067 catalytic residues [active] 1124983019068 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1124983019069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1124983019070 putative acyl-acceptor binding pocket; other site 1124983019071 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1124983019072 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1124983019073 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1124983019074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983019075 putative DNA binding site [nucleotide binding]; other site 1124983019076 putative Zn2+ binding site [ion binding]; other site 1124983019077 AsnC family; Region: AsnC_trans_reg; pfam01037 1124983019078 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1124983019079 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1124983019080 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1124983019081 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1124983019082 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1124983019083 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1124983019084 FAD binding pocket [chemical binding]; other site 1124983019085 FAD binding motif [chemical binding]; other site 1124983019086 phosphate binding motif [ion binding]; other site 1124983019087 beta-alpha-beta structure motif; other site 1124983019088 NAD binding pocket [chemical binding]; other site 1124983019089 Heme binding pocket [chemical binding]; other site 1124983019090 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1124983019091 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1124983019092 putative C-terminal domain interface [polypeptide binding]; other site 1124983019093 putative GSH binding site (G-site) [chemical binding]; other site 1124983019094 putative dimer interface [polypeptide binding]; other site 1124983019095 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1124983019096 putative N-terminal domain interface [polypeptide binding]; other site 1124983019097 putative dimer interface [polypeptide binding]; other site 1124983019098 putative substrate binding pocket (H-site) [chemical binding]; other site 1124983019099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1124983019100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1124983019101 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1124983019102 putative effector binding pocket; other site 1124983019103 putative dimerization interface [polypeptide binding]; other site 1124983019104 PAAR motif; Region: PAAR_motif; pfam05488 1124983019105 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1124983019106 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1124983019107 glutaminase active site [active] 1124983019108 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1124983019109 dimer interface [polypeptide binding]; other site 1124983019110 active site 1124983019111 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1124983019112 dimer interface [polypeptide binding]; other site 1124983019113 active site 1124983019114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1124983019115 putative DNA binding site [nucleotide binding]; other site 1124983019116 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1124983019117 putative Zn2+ binding site [ion binding]; other site 1124983019118 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1124983019119 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 1124983019120 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1124983019121 Substrate binding site; other site 1124983019122 Mg++ binding site; other site 1124983019123 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1124983019124 active site 1124983019125 substrate binding site [chemical binding]; other site 1124983019126 CoA binding site [chemical binding]; other site 1124983019127 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1124983019128 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1124983019129 gamma subunit interface [polypeptide binding]; other site 1124983019130 epsilon subunit interface [polypeptide binding]; other site 1124983019131 LBP interface [polypeptide binding]; other site 1124983019132 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1124983019133 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1124983019134 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1124983019135 alpha subunit interaction interface [polypeptide binding]; other site 1124983019136 Walker A motif; other site 1124983019137 ATP binding site [chemical binding]; other site 1124983019138 Walker B motif; other site 1124983019139 inhibitor binding site; inhibition site 1124983019140 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1124983019141 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1124983019142 core domain interface [polypeptide binding]; other site 1124983019143 delta subunit interface [polypeptide binding]; other site 1124983019144 epsilon subunit interface [polypeptide binding]; other site 1124983019145 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1124983019146 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1124983019147 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1124983019148 beta subunit interaction interface [polypeptide binding]; other site 1124983019149 Walker A motif; other site 1124983019150 ATP binding site [chemical binding]; other site 1124983019151 Walker B motif; other site 1124983019152 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1124983019153 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1124983019154 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1124983019155 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1124983019156 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1124983019157 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1124983019158 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1124983019159 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1124983019160 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1124983019161 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1124983019162 ParB-like nuclease domain; Region: ParBc; pfam02195 1124983019163 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1124983019164 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1124983019165 P-loop; other site 1124983019166 Magnesium ion binding site [ion binding]; other site 1124983019167 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1124983019168 Magnesium ion binding site [ion binding]; other site 1124983019169 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1124983019170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1124983019171 S-adenosylmethionine binding site [chemical binding]; other site 1124983019172 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1124983019173 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1124983019174 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1124983019175 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1124983019176 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1124983019177 putative proline-specific permease; Provisional; Region: proY; PRK10580 1124983019178 Spore germination protein; Region: Spore_permease; cl17796 1124983019179 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1124983019180 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1124983019181 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1124983019182 G1 box; other site 1124983019183 GTP/Mg2+ binding site [chemical binding]; other site 1124983019184 Switch I region; other site 1124983019185 G2 box; other site 1124983019186 Switch II region; other site 1124983019187 G3 box; other site 1124983019188 G4 box; other site 1124983019189 G5 box; other site 1124983019190 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1124983019191 membrane protein insertase; Provisional; Region: PRK01318 1124983019192 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1124983019193 hypothetical protein; Provisional; Region: PRK14371 1124983019194 ribonuclease P; Reviewed; Region: rnpA; PRK00396